Chapter 30 Vocabulary: adrenal cortex- mediates the stress response through the production of mineralocorticoids and glucocorticoids, including aldosterone and cortisol respectively. It is also a secondary site of androgen synthesis. adrenal glands- a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine adrenal medulla- makes epinephrine (adrenaline) and norepinephrine (noradrenaline) It is located at the center of the gland, being surrounded by the adrenal cortex hypothalamus- region of the forebrain below the thalamus that coordinates both the autonomic nervous system and the activity of the pituitary, controlling body temperature, thirst, hunger, and other homeostatic systems, and involved in sleep and emotional activit thyroid gland- a large ductless gland in the neck that secretes hormones regulating growth and development through the rate of metabolism pituitary gland- the major endocrine gland. A pea-sized body attached to the base of the brain, the pituitary is important in controlling growth and development and the functioning of the other endocrine glands. anterior pituitary- develops embryonically from the roof of the mouth and secretes growth hormone, LH, FSH, ACTH, TSH, and MSH posterior pituitary- develops from the back of the forebrain andsecretes the hormones vasopressinand oxytocin adrenergic receptors- targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline). target cells- a cell that bears receptors for a hormone, drug, or other signaling molecule, or is the focus of contact by a virus, phagocyte, nerve fiber, etc aldosterone- a corticosteroid hormone that stimulates absorption of sodium by the kidneys and so regulates water and salt balance. androgens- stimulates or controls the development and maintenance of male characteristics in vertebrates by binding to androgen receptors antidiuretic hormone (ADH)- A relatively small (peptide) molecule that is released by the pituitary gland at the base of the brain after being made nearby (in the hypothalamus). ADH has an antidiuretic action that prevents the production of dilute urine calcitonin- a hormone secreted by the thyroid that has the effect of lowering blood calcium calcitriol- a form of vitamin D corticosterone- a hormone secreted by the adrenal cortex, one of the glucocorticoids cortisol- a steroid hormone produced by the adrenal cortex and used medicinally to treat inflammation resulting from eczema and rheumatism epinephrine- a hormone secreted by the adrenal glands, especially in conditions of stress, increasing rates of blood circulation, breathing, and carbohydrate metabolism and preparing muscles for exertion. estrogens- a group of steroid hormones that promote the development and maintenance of female characteristics of the body. Such hormones are also produced artificially for use in oral contraceptives or to treat menopausal and menstrual disorders follicle-stimulating hormone (FSH)- a hormone secreted by the anterior pituitary gland that promotes the formation of ova or sperm. glucocorticoids- any of a group of corticosteroids (e.g., hydrocortisone) that are involved in the metabolism of carbohydrates, proteins, and fats and have anti-inflammatory activity gonadotropin-releasing hormone (GnRH)- also known as luteinizing hormone-releasing hormone(LHRH) and luliberin, is a trophic peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. gonadotropins- any of a group of hormones secreted by the pituitary that stimulate the activity of the gonads growth hormone (GH)- a hormone that stimulates growth in animal or plant cells, especially (in animals) a hormone secreted by the pituitary gland. juvenile hormone (JH)- any of a number of hormones regulating larval development in insects and inhibiting metamorphosis. luteinizing hormone (LH)- a hormone secreted by the anterior pituitary gland that stimulates ovulation in females and the synthesis of androgen in males. mineralocorticoids- a corticosteroid, such as aldosterone, that is involved with maintaining the salt balance in the body. norepinephrine- a neurotransmitter, released by adrenergic nerve terminals in the autonomic and possibly the central nervous system, that has such effects as constricting blood vessels, raising blood pressure, and dilating bronchi. oxytocin- a hormone released by the pituitary gland that causes increased contraction of the uterus during labor and stimulates the ejection of milk into the ducts of the breasts. parathyroid glands- are small endocrine glands in the neck of humans and other tetrapods that produce parathyroid hormone parathyroid hormone (PTH)- regulates calcium levels in a person's body progesterone- a steroid hormone released by the corpus luteum that stimulates the uterus to prepare for pregnancy thyroid-stimulating hormone (TSH)- a hormone secreted by the pituitary gland that regulates the production of thyroid hormones thyrotropin-releasing hormone (TRH)- a hormone secreted by the hypothalamus that stimulates release of thyrotropin thyroxine- the main hormone produced by the thyroid gland, acting to increase metabolic rate and so regulating growth and development Chapter 30 Questions: 1. Hormone: a regulatory substance produced in an organism and transported in tissue fluids such as blood or sap to stimulate specific cells or tissues into action. 2. Gland: an organ in the human or animal body that secretes particular chemical substances for use in the body or for discharge into the surroundings. 3. Exocrine gland: a gland that has a duct. These ducts help transport the secretions of the gland. (ex: sweat glands) Endocrine glands are those that do not have a duct system to help transport secretions. Instead, they secrete hormones that travel through the blood to the desired location. 4. Autocrine regulator: a regulator that is produced and acts within the same tissue of an organ. Paracrine regulator: one that is produced in one tissue but regulates another tissue of the same organ. 5. The body regulates the production and distribution of hormones through the endocrine system. The pituitary gland and the hypothalamus are responsible for the secretion of hormones. The hormones are then distributed by the blood throughout the body. Once they are distributed, the hormone levels can be regulated through releasing inhibiting hormones, monitoring nutrition, and varying the number of receptors present. 6. Since growth hormone is water-soluble, it would most likely act on its target cell like other water-soluble hormones. These hormones bind to a receptor cell on the plasma membrane of a cell. This then triggers an intracellular signaling chain. 7. Epinephrine and norepinephrine are responses to short term stress. They help signal the flight or fight response. They use glycogen reserves for immediate energy and increase the amount of oxygen flowing throughout the body while restricting blood flow to those areas less important. Cortisol responds to long term stress. When the glycogen reserves are all out, cortisol uses fat to create ATP. It also has antiinflammatory aspects. Because of the different functions of these hormones, they have differences in their courses of action. 8. Pheromones are not considered hormones because they do not exist inside the body. They are airborne molecules that get a reaction from a member of the same species. They do not have a role in the body, only make us feel certain ways based on the scent someone/something is giving off. 9. Relay signals from cell surface to target molecules in the cytosol or nucleus. 10. A change in some variable results in the opposite change in a second variable. 11. Hypercalcemia is hard to control and has very bad effects whereas the cancer is usually slow growing. 12. in metabolism; signal is amplified by catalyzing molecule that produces many product molecules. long signaling chains have large potential for amplification of the signal 13. Vertebrate: secretes hormones from endocrine glands Invertebrate: secretes nerve cells from exocrine glands 14. Hypothalamus is the link between the endocrine and nervous system, controls pituitary gland by stimulating or suppressing hormones from pituitary. 15. no bigger than a pea, 2 lobes, located at the base of the brain; releases growth hormone, oxytocin, prolactin, corticotropin, thyrotropin, endorphins, and antidiuretic hormone 16. GH- Acromegaly: Enlarged extremities TSH- Hypothyroidism: underactive thyroid, causes weight gain, fatigue, feeling cold Hyperthyroidism: overactive thyroid, causes weight loss, rapid heart beat, nervousness, feeling hot Glucagon/insulin- Diabetes: lack of insulin/ lack of response to insulin by the body, results in eye problems, heart disesase Adrenal Cortisol- Cushing’s syndrome: too much cortisol; causes thin skin, easy bruises, muscle weakness oxytocin peptide of 9 amino acids hypothalamus childbirth estrogen/ progesterone steroid compound ovaries menstrual cycle cortisol glucocorticoid adrenal glands metabolism and stress management growth hormone protein pituitary gland bodily growth. TSH/LH/FSH protein pituitary gland regulates and secretes estrogen and testosterone Aldosterone/ Mineralocorticoids/ Glucocorticoids/ Cortisol/ Corticosterone/ Androgens steroids Adrenal cortex regulate blood pressure; turn down immune activity/antistress; male sex hormone Calcitriol steroid derivative Kidney active form of vitamin D Epinephrine/ norepinephrine tyrosine derivative Adrenal Medulla adrenaline; helps engage flight or fight responses GnRH/TRH/ Gonadotrophins peptide hypothalamus stimulates secretion of LH and FSH PTH protein parathyroid glands increase blood calcium levels Thyroxine/Calcitonin peptide thyroid gland development; maturation; metabolism ADH peptide pituitary gland conserve body water and regulate tonicity of body fluids