D.D. Eisenhower Army Medical Center Department of Clinical Investigation
Clinical Investigation Research Laboratories: The Rest of the Story
MAJ Jeremy L. Goodin Ph.D.
OIC, Clinical Investigation Laboratory
Research, Education and Training for the Advancement of Military Medicine

D.D. Eisenhower Army Medical Center Department of Clinical Investigation
Presentation Outline
I.
DCI Organization
II. Roles of DCI Officer-in-Charge (OIC)
III. Unique Capabilities
IV. DCI Comparison to Army Research Institutes
V. Conclusions
Research, Education and Training for the Advancement of Military Medicine

D.D. Eisenhower Army Medical Center Department of Clinical Investigation
Disclaimer
The content presented is the opinion of the author and does not reflect the views or policies of the U.S. Army. Mention of trade names, commercial products or organizations do not imply an endorsement by the U.S. government.
Common Sense - identifying particular items of knowledge as
"common sense" is difficult in the Army.
Perception - What one perceives is a result of interplays between past experiences, including one’s culture, and the interpretation of the perceived.
Relativism - the idea that some elements or aspects of experience or culture are relative to other elements or aspects. Humans can understand and evaluate beliefs and behaviors only in terms of their historical or cultural context.
Research, Education and Training for the Advancement of Military Medicine

D.D. Eisenhower Army Medical Center Department of Clinical Investigation
DCI Mission
• Support graduate and continuing medical education
• Provide guidance and support for research
• Provide an academic milieu conducive to retention and recruitment of personnel
• Foster an atmosphere of inquiry
• Provide a review body for evaluation of research proposals
• Promote the highest level of professional standards in the conduct of human and animal research
Research, Education and Training for the Advancement of Military Medicine

Red = vacant
D.D. Eisenhower Army Medical Center Department of Clinical Investigation
Department of Clinical Investigation
Research Administration Section
DDEAMC, Fort Gordon GA 30905
Phone: 706-787-5384
Department of Clinical Investigation
Research Laboratory and Education Section
BLDG 38705 Fort Gordon GA 30905
Phone: 706-787-0006
Chief, DCI
Secretary
Human Protections Admin
Clinical Research Protocol Administrative
Processing Section
Case Manager
Protocol Coordinator x 2
Assistant Chief Dept/Lab Manager
DCI Research and Training Laboratory
OIC-71B
NCOIC-E6
NCO-E5
Human Use Section
IRB Function
Animal Use Section
IACUC Function
Molecular Biology Section
Staff Scientist Ph.D.
Research Tech
Microbiology Section
CPT-71A
Biomedical Eng
Publication Review and
Clearance Section
Regulatory Assurance and
Regulated Studies Section
Physiology and Cellular
Biology Section
Staff Scientist Ph.D.
Staff Scientist, Ph.D.
Laboratory Animal Support
Veterinarian-DVM
Animal Tech x 3
Research, Education and Training for the Advancement of Military Medicine
2Q FY 2010

D.D. Eisenhower Army Medical Center Department of Clinical Investigation
Additional Personnel
Contract Personnel
3-5 Research Assistants/Technicians
1 Biomedical Engineer
1 Statistician
1 Veterinarian
1-2 Assistant Protocol Coordinators
Residents
3 full time surgery residents
3-6 additional medical residents
4-6 dental residents
Volunteer Personnel
Research, Education and Training for the Advancement of Military Medicine

D.D. Eisenhower Army Medical Center Department of Clinical Investigation
• Supervision and comprehensive management of the EAMC Clinical
Investigation Research Facility.
• Responsible for successful execution of the DCI mission: multidisciplinary military-relevant research, education and training programs.
• Rate or senior rate civilian and military personnel.
• Serve as senior military research scientist, principle investigator and subject matter expert for the medical and dental residency programs.
• Supervise the development of all clinical investigation research projects
• Serve as Chair, Institutional Animal Care and Use Committee (IACUC).
• Serve as acting DCI Chief as needed.
• Serve as Contracting Officer’s Representative for multiple contracts.
Research, Education and Training for the Advancement of Military Medicine

D.D. Eisenhower Army Medical Center Department of Clinical Investigation
Research, Education and Training for the Advancement of Military Medicine

•Quantitative Real-time PCR
•Microarrays
•Immunohistochemistry
•Instron materials testing
•Confocal/Fluorescent
Microscopy
•Kodak In-vivo FX Imager
•Faxitron X-ray Imager
•SEM Electron Microscope
•HPLC
•ELISA
•Nanodrop Spectrophotometry
•In-house Vivarium
•Surgical Suite

• Allows for isolation of specific cells of interest from thin tissue sections
• Very useful for collection of specific cell types for
DNA, RNA or protein analysis
Breast Duct Epithelial Cells Modular Stage

Bone Chip
2000X
Disk

Application areas:
• Tensile strength testing
• Compressive strength testing
• Fatigue testing
• Flexural strength testing
• Impact force testing
DCI testing has involved:
• Adhesive Sutures
• Resorbable Screws
• External Fixatures

Animal models of human disease
Training labs for procedures, surgeries

D.D. Eisenhower Army Medical Center Department of Clinical Investigation
Research, Education and Training for the Advancement of Military Medicine

D.D. Eisenhower Army Medical Center Department of Clinical Investigation
METT-TC based comparison of U.S. Army Research
Institutes to U.S. Army Clinical Investigation Laboratory
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Research, Education and Training for the Advancement of Military Medicine

Research Institute
Research is the focus
Funding driven, salaries directly tied to research proposals
Applied science,
Product oriented,
Milestone driven
Clinical Investigation
Patient care is the priority
Less emphasis on funding, salaries part of hospital budget
Basic science,
Product oriented, but the products are education and training
© Jeff Jones 2010

Research Institute
Bureaucracy
Bureaucracy
Bureaucracy
Bureaucracy
Bureaucracy
Clinical Investigation
Bureaucracy
Bureaucracy
Bureaucracy
Bureaucracy is the collective organizational structure, procedures, protocols, and set of regulations in place to manage activity.

Research Institute
Similar to Industry
Very tight security
Clinical Investigation
Similar to Academia
Much less stringent security
© Jeff Jones 2010

Research Institute
~300-700 total workforce
~50-100 military
All personnel and support focused on
Research as the primary mission
Clinical Investigation
~3,000 total workforce
~1,000 military
DCI personnel focused on Research,
Education and Training
Hospital support personnel turn around time can sometimes be slow

Research Institute Clinical Investigation
Many “hard” deadlines and suspense dates due to funding cycles
~75% of time available to conduct research if in “investigator” position
~0% of time available to conduct research if in management or staff officer position
Some deadlines - residents have time constraints
~40% of time available to conduct research in OIC position

Research Institute
Majority of workforce are civilian and contractor
Civilian personnel issues may require a great deal of time and energy
Civilian’s have added pressure of competitive funding
Clinical Investigation
Majority of workforce are civilian and contractor
Civilian personnel issues may require a great deal of time and energy

D.D. Eisenhower Army Medical Center Department of Clinical Investigation
Rater Senior Rater Location
Service School
RIID-2003
(120 Day OER)
RIID-2004
RIID-2004
Service School
RIID-2006
MRICD-2007
MRICD-2008
MRICD-2009
MRICD-2009
EAMC-2010
71A-LTC (Microbiology)
DB3-Civilian (Scientist)
DB4-Civilian (Scientist)
71A-LTC
71A-LTC
71A-LTC
DB4-Civilian (Scientist)
71A-LTC (Microbiology)
64D-LTC (Veterinarian)
71A-LTC
71B-COL (Dep CDR)
71B-COL (Dep CDR)
SES-Civilian (Operations) 64C-COL (Dep CDR)
GS14-Civilian (Operations) 64C-COL (Dep CDR)
YG3-Civilian (Physician) 61F-COL (Dep CDR)
(Physician)
Research, Education and Training for the Advancement of Military Medicine

D.D. Eisenhower Army Medical Center Department of Clinical Investigation
MAJ Jeremy L. Goodin Ph.D.
OIC, Clinical Investigation Laboratory
Research, Education and Training for the Advancement of Military Medicine