Chapter 11
Regression and Correlation
methods
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Learning Objectives
1.
Describe the Linear Regression Model
2.
State the Regression Modeling Steps
3.
Explain Ordinary Least Squares
4.
Compute Regression Coefficients
5.
Understand and check model assumptions
6.
Predict Response Variable
7.
Comments of SAS Output
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Learning Objectives…
8.
Correlation Models
9.
Link between a correlation model and a
regression model
10.
Test of coefficient of Correlation
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Models
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What is a Model?
1.
Representation of
Some Phenomenon
Non-Math/Stats Model
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What is a Math/Stats Model?
1.
Often Describe Relationship between
Variables
2.
Types
-
Deterministic Models (no randomness)
-
Probabilistic Models (with randomness)
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Deterministic Models
Hypothesize Exact Relationships
2. Suitable When Prediction Error is Negligible
3. Example: Body mass index (BMI) is measure of
body fat based
1.


Metric Formula: BMI = Weight in Kilograms
(Height in Meters)2
Non-metric Formula: BMI = Weight (pounds)x703
(Height in inches)2
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Probabilistic Models
1.
2.
Hypothesize 2 Components
• Deterministic
• Random Error
Example: Systolic blood pressure of newborns
Is 6 Times the Age in days + Random Error
• SBP = 6xage(d) + 
• Random Error May Be Due to Factors
Other Than age in days (e.g. Birthweight)
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Types of
Probabilistic Models
Probabilistic
Models
Regression
Models
Correlation
Models
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Other
Models
9
Regression Models
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Types of
Probabilistic Models
Probabilistic
Models
Regression
Models
Correlation
Models
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Other
Models
11
Regression Models
 Relationship
between one dependent
variable and explanatory variable(s)
 Use equation to set up relationship
• Numerical Dependent (Response) Variable
• 1 or More Numerical or Categorical Independent
(Explanatory) Variables
 Used
Mainly for Prediction & Estimation
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Regression Modeling Steps
 1.
Hypothesize Deterministic Component
• Estimate Unknown Parameters
 2.
Specify Probability Distribution of
Random Error Term
• Estimate Standard Deviation of Error
 3.
Evaluate the fitted Model
 4.
Use Model for Prediction & Estimation
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Model Specification
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Specifying the deterministic
component
 1.
Define the dependent variable and
independent variable
 2.
Hypothesize Nature of Relationship



Expected Effects (i.e., Coefficients’ Signs)
Functional Form (Linear or Non-Linear)
Interactions
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Model Specification
Is Based on Theory
 1.
Theory of Field (e.g., Epidemiology)
 2. Mathematical Theory
 3. Previous Research
 4. ‘Common Sense’
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Thinking Challenge:
Which Is More Logical?
CD+ counts
Years since seroconversion
CD+ counts
Years since seroconversion
CD+ counts
Years since seroconversion
CD+ counts
Years since seroconversion
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OB/GYN Study
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Types of
Regression Models
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Types of
Regression Models
Regression
Models
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Types of
Regression Models
1 Explanatory
Variable
Regression
Models
Simple
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Types of
Regression Models
1 Explanatory
Variable
Regression
Models
2+ Explanatory
Variables
Multiple
Simple
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Types of
Regression Models
1 Explanatory
Variable
Regression
Models
2+ Explanatory
Variables
Multiple
Simple
Linear
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Types of
Regression Models
1 Explanatory
Variable
Regression
Models
Multiple
Simple
Linear
2+ Explanatory
Variables
NonLinear
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Types of
Regression Models
1 Explanatory
Variable
Regression
Models
2+ Explanatory
Variables
Multiple
Simple
Linear
NonLinear
Linear
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Types of
Regression Models
1 Explanatory
Variable
Regression
Models
2+ Explanatory
Variables
Multiple
Simple
Linear
NonLinear
Linear
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NonLinear
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Linear Regression
Model
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Types of
Regression Models
1 Explanatory
Variable
Regression
Models
2+ Explanatory
Variables
Multiple
Simple
Linear
NonLinear
Linear
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NonLinear
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Linear Equations
Y
Y = mX + b
m = Slope
Change
in Y
Change in X
b = Y-intercept
X
© 1984-1994 T/Maker Co.
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Linear Regression Model
 1.
Relationship Between Variables Is a
Linear Function
Population
Y-Intercept
Population
Slope
Random
Error
Yi   0  1X i   i
Dependent
(Response)
Variable
(e.g., CD+ c.)
Independent
(Explanatory) Variable
(e.g., Years s. serocon.)
Population & Sample
Regression Models
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Population & Sample
Regression Models
Population





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Population & Sample
Regression Models
Population
Unknown
Relationship

Yi   0  1X i   i




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Population & Sample
Regression Models
Random Sample
Population
Unknown
Relationship

Yi   0  1X i   i






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Population & Sample
Regression Models
Random Sample
Population
Unknown
Relationship

Yi   0  1X i   i



Yi   0   1X i   i





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Population Linear Regression
Model
Y
Yi   0  1X i   i
Observed
value
i = Random error
E Y   0  1 X i
X
Observed value
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Sample Linear Regression
Model
Y


Yi   0   1X i   i
^i = Random
error



Yi   0   1X i
Unsampled
observation
X
Observed value
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Estimating Parameters:
Least Squares Method
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Scatter plot
 1.
Plot of All (Xi, Yi) Pairs
 2. Suggests How Well Model Will Fit
60
40
20
0
Y
0
20
40
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X
60
39
Thinking Challenge
How would you draw a line through the
points? How do you determine which line
‘fits best’?
60
40
20
0
Y
0
20
40
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X
60
40
Thinking Challenge
How would you draw a line through the
points? How do you determine which line
‘fits best’?
Slope changed
60
40
20
0
Y
0
20
40
X
60
Intercept unchanged
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Thinking Challenge
How would you draw a line through the
points? How do you determine which line
‘fits best’?
Slope unchanged
60
40
20
0
Y
0
20
40
X
60
Intercept changed
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Thinking Challenge
How would you draw a line through the
points? How do you determine which line
‘fits best’?
Slope changed
60
40
20
0
Y
0
20
40
X
60
Intercept changed
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Least Squares
‘Best Fit’ Means Difference Between
Actual Y Values & Predicted Y Values Are
a Minimum. But Positive Differences OffSet Negative ones
 1.
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Least Squares
‘Best Fit’ Means Difference Between
Actual Y Values & Predicted Y Values is a
Minimum. But Positive Differences Off-Set
Negative ones. So square errors!
 1.

n
i 1
Yi  Yˆi
   ˆ
2
n
2
i
i 1
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Least Squares
‘Best Fit’ Means Difference Between
Actual Y Values & Predicted Y Values Are
a Minimum. But Positive Differences OffSet Negative. So square errors!
 1.

n
i 1
Yi  Yˆi
   ˆ
2
n
2
i
i 1
 2.
LS Minimizes the Sum of the Squared
Differences (errors) (SSE)
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Least Squares Graphically
n
2
2
2
2
2





LS minimizes   i   1   2   3   4
i 1
Y2   0   1X 2   2
Y
^4
^2
^1
^3



Yi   0   1X i
X
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Coefficient Equations

Prediction equation
yˆi  ˆ0  ˆ1 xi

Sample slope
SS xy   xi  x  yi  y 
ˆ1 

2
SS xx


x

x
 i

Sample Y - intercept
ˆ0  y  ˆ1x
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Derivation of Parameters (1)

Least Squares (L-S):
Minimize squared error
n
n
    yi  0  1 xi 
i 1
0
 
 0
2
i
2
i

2
i 1
   yi   0  1 xi 
2
 0
 2  ny  n 0  n1 x 
ˆ0  y  ˆ1x
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Derivation of Parameters (1)

Least Squares (L-S):
Minimize squared error
2
   i2
   yi   0  1 xi 
0

1
1
 2 xi  yi   0  1 xi 
 2 xi  yi  y  1 x  1 xi 
1  xi  xi  x    xi  yi  y 
1   xi  x  xi  x     xi  x  yi  y 
SS xy
ˆ
1 
SS xx
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Computation Table
Xi
X1
Yi
2
Xi
2
Yi
XiYi
Y1
X1
2
Y1
2
X1Y1
2
Y2
2
X2Y2
X2
Y2
X2
:
:
:
:
2
Xn
Yn
Xn
Xi
Yi
2
Xi
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2
XnYn
2
Yi
XiYi
Yn
51
Interpretation of Coefficients
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Interpretation of Coefficients
 1.

^
Slope (1)
^
Estimated Y Changes by 1 for Each 1 Unit
Increase in X
• If ^1 = 2, then Y Is Expected to Increase by 2 for
Each 1 Unit Increase in X
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Interpretation of Coefficients
 1.

^
Slope (1)
Estimated Y Changes by ^1 for Each 1 Unit
Increase in X
^
• If  = 2, then Y Is Expected to Increase by 2 for
1
Each 1 Unit Increase in X
^
 2. Y-Intercept (0)

Average Value of Y When X = 0
• If ^0 = 4, then Average Y Is Expected to Be
4 When X Is 0
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Parameter Estimation Example
 Obstetrics: What is the relationship between
Mother’s Estriol level & Birthweight using the
following data?
Estriol
Birthweight
(mg/24h)
(g/1000)
1
2
3
4
5
1
1
2
2
4
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Scatterplot
Birthweight vs. Estriol level
Birthweight
4
3
2
1
0
0
1
2
3
4
5
6
Estriol level
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Parameter Estimation Solution
Table
Xi
Yi
Xi2
Yi2
XiYi
1
1
1
1
1
2
1
4
1
2
3
2
9
4
6
4
2
16
4
8
5
4
25
16
20
15
10
55
26
37
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Parameter Estimation Solution
n




X i   Yi 


n
i 1

 i 1 
X
Y


i i
n
i 1
n
ˆ1 


X
  i
n
i 1
2


X


i
n
i 1
n
2


1510 
37 
5
2

15
55 
5
 0.70
ˆ0  Y  ˆ1 X  2  0.703  0.10
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Coefficient Interpretation
Solution
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Coefficient Interpretation
Solution
 1.

^
Slope (1)
Birthweight (Y) Is Expected to Increase by .7
Units for Each 1 unit Increase in Estriol (X)
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Coefficient Interpretation
Solution
 1.

 2.

^
Slope (1)
Birthweight (Y) Is Expected to Increase by .7
Units for Each 1 unit Increase in Estriol (X)
^
Intercept (0)
Average Birthweight (Y) Is -.10 Units When
Estriol level (X) Is 0
• Difficult to explain
• The birthweight should always be positive
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SAS codes for fitting a simple linear
regression

Data BW; /*Reading data in SAS*/
 input estriol birthw@@;
 cards;
 1
1
2
1
3
2
4 2
5
4
 ;
 run;



PROC REG data=BW; /*Fitting linear regression
models*/
model birthw=estriol;
run;
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Parameter Estimation
SAS Computer Output
Parameter Estimates
Variable
DF
Intercept
Estriol
^0
1
1
Parameter
Estimate
-0.10000
0.70000
Standard
Error t Value
0.63509
0.19149
-0.16
3.66
Pr > |t|
0.8849
0.0354
^

1
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Parameter Estimation Thinking
Challenge
You’re a Vet epidemiologist for the county
cooperative. You gather the following data:
 Food (lb.) Milk yield (lb.)
4
3.0
6
5.5
10
6.5
12
9.0
 What is the relationship
between cows’ food intake and milk yield?

© 1984-1994 T/Maker Co.
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Scattergram
Milk Yield vs. Food intake*
M. Yield (lb.)
10
8
6
4
2
0
0
5
10
15
Food intake (lb.)
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Parameter Estimation Solution
Table*
Xi
Yi
2
Xi
4
3.0
16
9.00
12
6
5.5
36
30.25
33
10
6.5
100
42.25
65
12
9.0
144
81.00
108
32
24.0
296 162.50 218
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Yi
XiYi
66
Parameter Estimation Solution*
n




X i   Yi 


n
i 1

 i 1 
X
Y


i i
n
i 1
n
ˆ1 


X
  i
n
i 1
2


X


i
n
i 1
n
2


32 24
218 
4
2

32 
296 
4
 0.65
ˆ0  Y  ˆ1 X  6  0.658  0.80
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Coefficient Interpretation
Solution*
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Coefficient Interpretation
Solution*
 1.

^
Slope (1)
Milk Yield (Y) Is Expected to Increase by .65
lb. for Each 1 lb. Increase in Food intake (X)
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Coefficient Interpretation
Solution*
 1.

 2.

^
Slope (1)
Milk Yield (Y) Is Expected to Increase by .65
lb. for Each 1 lb. Increase in Food intake (X)
Y-Intercept (0)
^
Average Milk yield (Y) Is Expected to Be 0.8
lb. When Food intake (X) Is 0
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