FOM 1211
Digestion, Nutrition and Metabolism
5 Weeks
Course description
This course introduces students to structures, their function and molecules involved in digestion,
nutrition and metabolism in humans. The processes through which food goes through from the time of
obtaining it to the time it is utilized by the human body cells and the laboratory investigations which
could be done when thing go wrong.
Course Objectives:
This course will enable the students to:
1. Describe the anatomy and function of the GIT
2. Describe the metabolism of biomolecules in the cell
3. State the major nutrients, their sources and importance in the human body
4. Describe the functions and optional maintenance of the major nutrients
5. Describe the role of the relevant laboratory investigations
Expected outcomes
1. Demonstration of ability to identify and describe the structures of the GIT
2. Appreciation of the function of the GIT structures
3. Appreciation of the molecules involved in metabolism
4. Demonstration of skills in determining blood glucose levels,
Content outline:
1. Anatomy
• Embryology and histology of GIT
• Gross Anatomy of the GIT
• Oral cavity
• Pharynx
• Oesophagus
• Stomach
• Duodenum, jejunum and Ileum (small intestine)
• Colon
• Rectum and anal canal
Functional Anatomy of associated organs
Liver and Biliary system
Gall bladder
Pancreas
2. Nutrition
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Proteins
Carbohydrates
Lipids
Micronutrients
Vitamins
Minerals/Electrolytes (Fe2+, Ca2+, Zinc, Na+, k+, Cl-, phosphates)
Energy and Nitrogen balance
Dietary standards, food and food consumption
Techniques for assessing human nutritional status
3. Physiology
• Gastro intestinal hormones
• Chewing and swallowing
• Movements of the stomach, gastric emptying and anti peristaltic movement
• Movements of small intestine
• Movement of large intestine
• Defecation and passage of flatus
• Gases of GIT
• Digestive secretions
• Saliva
• Gastric juice
• Pancreatic juice
• Bile
• Digestion and Absorption of
• Carbohydrates
• Proteins
• Lipids
• Vitamin/Electrolytes/Minerals/H2O
• Functions of the liver
4. Biochemistry
• Carbohydrates metabolism
• Glycolysis
• TCA cycle
• Oxidative Phosphorylation
• Gluconeogenesis
• Pentose Phosphate pathway
• Glycogen metabolism
• Glycogen breakdown
• Glycogen synthesis
Control glycogen metabolism
Glycogen storage disease
Lipid metabolism
• Oxidation of fatty acids
• Fatty acid biosynthesis
• Regulation of fatty acid synthesis and breakdown
• Diseases associated with lipid metabolism
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Protein metabolism
Amino acid synthesis
Catabolism of amino acids
Inborn errors of metabolism
Metabolism of purines, pyrimidines and porphyrins
Diseases of PPP metabolism
Thermodynamics - energy conservation and transformation.
Assessment methods
Students are assessed through formative and summative means. These shall include
c) Continuous assessment during the entire problem based learning sessions. This permits
immediate fed back to every student.
d) An end of course progressive examination consisting of
• Extended marching questions items
• Multiple choice questions
• Short answer questions
These two assessments contribute 40% of the final mark for the course
c) An end of the block examination (summative) consisting of
• Extended marching questions items
• Multiple choice questions
• Short answer questions
• Viva voce
• Practical
This will contribute 60% of the final mark for the course
Methods of delivery
Over view lectures, Small tutorial sessions with a tutor, Expert resource seminars, wrap up seminars,
clinical exposures, and practical sessions
Course duration: 5 weeks, 75 CH
Resources and infrastructure available
Library (in the department of Anatomy, Physiology ,Biochemistry and Albert Cook ,tutorial rooms,
computer services and internet, content experts, patients and teaching hospital, competent guest
lecturers.
Teaching Staff
Name
Prof Sam Luboga
Prof Gabriel Nzrubara
Dr. C.Ibingira
Dr. Buwembo William
Dr. Ochieng Joseph
Dr.Turyabahika Joseph
Dr. H. Kiryowa
Dr. Kayondo
Dr.J. Kasolo
Dr. J. Okullo
Qualifications
PhD
M.MED
M.MED
M.Sc
M.Sc
M.MED
M.Sc
BDS
M.Sc
M.Sc
Employer
Makerere University
Makerere University
Makerere University
Makerere University
Makerere University
Makerere University
Makerere University
Makerere University
Makerere University
Makerere University
3
Fulltime part time
Fulltime
Fulltime
Fulltime
Fulltime
Fulltime
Fulltime
Fulltime
Fulltime
Fulltime
Fulltime
Dr. R. Nakiboneka
Dr. Ebuku
Dr. D.Ntulume
Mr.H.Kasozi
Mr. A.Lugaajju
Prof F.Kironde
Dr.J.Haumba
M.Sc
M.Sc
M.Sc
M.Sc
M.Sc
PhD
PhD
Makerere University
Makerere University
Makerere University
Makerere University
Makerere University
Makerere University
Makerere University
4
Fulltime
Fulltime
Fulltime
Fulltime
Fulltime
Fulltime
Fulltime