Bioinformatics
Necessary evil, panacea, or just a
useful tool?
With a month in the lab you can
easily prevent having to sit an
hour in front of the computer.
Nothing is impossible for a
biologist who doesn’t have to
discover it him/her-self.
Bio + informatica
Humaan genoom
Humaan genoom
....acccaa gaagtcagaa tcctcgaagc tgaagcctga ctgtaagctc tgcctcctac
aactagacaa gtcacaatgc aacccctttg ctccagagga aaaggagtaa gcacagaggg
cttctgagtc cggcaatgct ccatttcctg acaggagcat tttacagact tgcgtctgcc
cctctgaggg aggcagggcc atcagctaac actcagagac aaggatggtc ctacaacatc
ctgatctggg aggaagaggt gaaggcaact caccaccctc aggcatctta acagaaaaca
gtggaactaa ggctcattct aaagaatgtg cccaagatca cacaccgaag gctgcaaagc
gagagtcaaa cttggaaccc tgaacctgca cttgtccctt tacactgccc tgcagcatgg
atgcgatggc tgggcagagg gaagtgccca agcctgggga caaaaatgcc tacctg....
Chromosomes
Genome annotation
Bioinformatics
and medicines
One day we know everything
about all human (and flu)
proteins and then can we start
to ‘calculate’ flu-medicines.
Drug Design
GPCR
Drug Design
Mens vs parasiet
Parasite
Active site
Medicine
Every small molecule is, in
principle, a poison. We call it a
flu-medicine if it kills the flu
much faster than the patient.
H1N1 / H5N1
H1N1
Strange mortality 1918
(the 1918 flu was H1N1)
Same strange mortality
in Mexican H1N1? Why?
Flu bioinformatics
Determine which variant it is
from sequence comparisons
Design medicine(s) (tamivir, etc)
Determine why H1N1 is
dangerous
Predict next variant
Bird/pig flu
Pig flu pandemic?
H5N1
(but H1N1 also went through birds)
Neuraminidase
Quote from Wikipedia/WHO/etc:
On February 27, 2005, a 14-year-old Vietnamese girl was
documented to be carrying an H5N1 influenza virus strain
that was resistant to the drug oseltamivir. However, the
Vietnamese girl who had received a prophylactic dose (75
mg once a day) was found to be non-responsive to the
medication. In growing fears of a global avian flu pandemic,
scientists began to look for a cause of resistance to the
Tamiflu medication. The cause was determined to be a
histidine-to-tryosine substitution at position 274 in its
neuraminidase protein
H1N1 medicijn