Fig 7-48.
An order of events leading to transcription initiation at a specific promoter

Eucaryotic gene repressor proteins can inhibit transcription in various ways
Fig 7-49.

Fig 7-49. (continued)

Eucaryotic gene regulatory proteins often assemble into complexes on DNA

Enhancesome : A more elaborate protein-DNA structure

Complex genetic switches that regulate Drosophila development are built up from smaller modules
The nonuniform distribution of four gene regulatory proteins.

Red: Giant protein

- Regulatory region of eve gene is formed from a series of relatively simple regional regulatory modules .
- Each of regional regulatory modules contains multiple regulatory sequences .

The drosophila eve gene is regulated by combinatory controls
Fig. 7-55. Close-up view of the eye stripe 2 unit.
Bicoid and Hunchback: activate eve transcription
Kruppel and Giant: repress eve transcription

Bicoid and Hunchback: activate eve transcription
Kruppel and Giant: repress eve transcription

The promoter integrates the transcription cues provided by all of the bound proteins
Integration at a promoter
?