The separation of pharmacy and medicine in Europe
Edict of Salerno, 1241
Frederick II issued a number of rules aimed at
protecting the patient such as
 Supervision of both professions by
governmental agencies
 Fixed pices (tariff) for drugs, preparations
and services
 Prohibition of shared practice settings for
physicians and pharmacists
Frederick II (1194-1250)
Holy Roman Emperor
King of Sicily, Germany, and Jerusalem
(2009)
 Dept. of Experimental and Clinical
Pharmacology
Medicine
Public Health
Pharmacy
Dentistry
Nursing
Vet. Medicine
(Tim Tracy)
 Dept. of Pharmaceutics
(Ron Siegel)
 Dept. of Medicinal Chemistry
(Gunda Georg)
 Dept. of Pharmacy Practice and
Pharmaceutical Sciences – Duluth
(Randy Seifert)
 Dept. of Pharmaceutical Care &
Health Systems
(Steve Schondelmeyer)
College of Pharmacy (CoP) student numbers
Students in the Pharm.D. program
648 professional students
1.100 applicants competed for 167 spots
Graduate students
104 students in 4 graduate programs
Few, if any, Pharm.D.s enroll in grad.
programs!
Employee Health and Wellness Center
College of Pharmacy (CoP) numbers:
faculty and finances
Faculty
97 voting faculty
Research funding
Federal
State
Other
$6,647,293
$2,385,739
$3,144,520
Development
$3,449,113
(UMF year-end gift activity report for FY ’08)
(2008)
 Dept. of Experimental and Clinical
Pharmacology
(Tim Tracy)
Medicine
Public Health
Pharmacy
Dentistry
Nursing
Vet. Medicine
 Dept. of Pharmaceutics
(Ron Siegel)
 Dept. of Medicinal Chemistry
(Gunda Georg)
 Dept. of Pharmacy Practice and
Pharmaceutical Sciences – Duluth
(Randy Seifert)
 Dept. of Pharmaceutical Care &
Health Systems
(Steve Schondelmeyer)
What does a Linguist do in Pharmacy?
 Assessing linguistic manifestations of cognitive
impairment resulting from neurodegenerative
disorders as well as exposure to medications
Serguei Pakhomov
Assistant Professor
CoP, PCHS
Education:
M.A. and Ph.D. in
English/Linguistics
Petrozavodsk Pedagogical
University, Russia - 1992
U of M 1994, 1999
 Using natural language processing and machine
learning in analyzing unstructured text of clinical
notes
 …results in inexpensive and scalable methods
for risk factor and quality assessment at the point
of care
(2008)
 Dept. of Experimental and Clinical
Pharmacology
(Tim Tracy)
Medicine
Public Health
Pharmacy
Dentistry
Nursing
Vet. Medicine
 Dept. of Pharmaceutics
(Ron Siegel)
 Dept. of Medicinal Chemistry
(Gunda Georg)
 Dept. of Pharmacy Practice and
Pharmaceutical Sciences – Duluth
(Randy Seifert)
 Dept. of Pharmaceutical Care &
Health Systems
(Steve Schondelmeyer)
Collaborative funding opportunities for Pharmacy
(Twin Cities/Duluth) and Public Health
Agency for Healthcare Research and Quality (AHRQ)
new FOAP, AR-08-270
Title: Utilizing Health Information Technology (IT) to Improve
Health Care Quality (R18)
Real world demonstration projects that evaluate factors
associated with successful health IT implementation and
ultimately improve health care outcomes.
…such as “Medication Therapy Management (MTM) in a rural
setting using ITV or similar telemedical approaches - comparison
with conventional in-person counseling”
Duluth Pier
Lighthouse
(2008)
 Dept. of Experimental and Clinical
Pharmacology
(Tim Tracy)
Medicine
Public Health
Pharmacy
Dentistry
Nursing
Vet. Medicine
 Dept. of Pharmaceutics
(Ron Siegel)
 Dept. of Medicinal Chemistry
(Gunda Georg)
 Dept. of Pharmacy Practice and
Pharmaceutical Sciences – Duluth
(Randy Seifert)
 Dept. of Pharmaceutical Care &
Health Systems
(Steve Schondelmeyer)
Developing probes to seek out DNA damage by carcinogens
Luminescent jack-o'-lantern mushrooms
contain DNA alkylating acylfulvenes
Shana Sturla
Assistant Professor
CoP, Med. Chem.
B.S., UC Berkeley, 1996
Ph.D., MIT, 2001
BULKY BINDING. Acylfulvenes form adducts with DNA.
Gong, J.; Sturla, S. J. A Synthetic Nucleoside Probe that
Discerns a DNA Adduct from Unmodified DNA. J Amer
Chem Soc, 2007, 129, 4882-4883
ITDD High Throughput Screening
Instrumentation
Plate Management/Automation
• Thermo/CRS Dimension 4 robotic system
Institute for Therapeutics Discovery & Development
DRUG DEVELOPMENT PIPELINE OF THE AHC-UMN
Aquavan in Pain
Tamiasyn in Trauma
Triptolide in Cancer
Gamendazol in Contracept
Toxoflavin in Contraception
TX-67 in Alzheimer’s
TH-2-237 in Alzheimer’s
Iminosugars in Contracept
Treg in Diabetes-Transplant
GM-Endostatin in Cancer
Pro-Triptolide in Cancer
Cardenolides in Contracept
Kinase Inhib in Contracept
Vaccine Adjuvant
sAC in Contraception
LDH-C in Contraception
DMRTI in Contraception
GMP
Manuf
(2008)
 Dept. of Experimental and Clinical
Pharmacology
(Tim Tracy)
Medicine
Public Health
Pharmacy
Dentistry
Nursing
Vet. Medicine
 Dept. of Pharmaceutics
(Ron Siegel)
 Dept. of Medicinal Chemistry
(Gunda Georg)
 Dept. of Pharmacy Practice and
Pharmaceutical Sciences – Duluth
(Randy Seifert)
 Dept. of Pharmaceutical Care &
Health Systems
(Steve Schondelmeyer)
Why Establish a Center for the Integration of
Drugs and Devices (CIDD)?
Drug/Device combination products will change the face of
healthcare.
“The future is combining devices and drugs.”
-- Ralph Larson, Chairman & CEO of J&J
BRAIN CANCER
GLIOBLASTOMA
Drug
Efflux Pump
100,000 Patients in USA – 20,000 Children
Median Survival: 12 months
Pump Inhibitor
TUMOR SIZE [mm3]
BLOOD
Drug
BLOOD
3
2
1
0
Cancer Drug
Cancer Drug +
Inhibitor
Overcoming Barriers in Treating Brain Diseases
CoP Brain Barriers Research Center, since 8/2008
2 Schools, 2 Campuses Pharmacy/Medicine, Twin Cities/Duluth
William Elmquist
Haim Einat
(director)
John Ohlfest
Les Drewes
Matthew Andrews
Anika Hartz
Bob Cormier
Bjoern Bauer
Ken Dornfeld
Grant Anderson
Joe Prohaska
Stephen Haines
Cornelius Lam
(2008)
 Dept. of Experimental and Clinical
Pharmacology
(Tim Tracy)
Medicine
Public Health
Pharmacy
Dentistry
Nursing
Vet. Medicine
 Dept. of Pharmaceutics
(Ron Siegel)
 Dept. of Medicinal Chemistry
(Gunda Georg)
 Dept. of Pharmacy Practice and
Pharmaceutical Sciences – Duluth
(Randy Seifert)
 Dept. of Pharmaceutical Care &
Health Systems
(Steve Schondelmeyer)
ECP Research Focus Areas (Disease States)






Hematology/Oncology
Infectious Disease
Cardiovascular Disease
Epilepsy
Critical Care
Renal Transplantation
CoP Center for Forecasting Drug Response
• Pharmacometrics
– Clinical Trial Simulation
– Trial Design
– Limited Sampling
Methodologies
– Population
Pharmacokinetics
– PharmacokineticPharmacodynamic
Analyses
5
10 mg/kg Q6H
15 mg/kg Q8H
4
3
2
1
0
24
28
32
36
TIME
40
44
48
#3 Ranking in U.S.News, up from #4
Out of 100 Pharmacy Schools:
Top 5 schools
University of CA-SF
University of N.C.Chapel Hill
University of Minnesota
University of TX-Austin
Ohio State University
Score
4.7
4.4
4.3
4.2
4.1