UKanTeach 5E Lesson Plan Author (s): Cody Alley and Jake Skinner Team Members: Cody Alley and Jake Skinner Title of Lesson: Patterns of Inheritance Lesson # 1 Date lesson will be taught: 2/22/13 Grade level: 9th Lesson Source (kit, lesson): Concepts/Main Idea – The purpose of this activity is to delineate the different types of gene expression and how alleles interact with each other. Students will be working on exercises to help solidify the concepts of dominance, codominance, incomplete dominance, etc. The exercises will involve mixing of genes and reading pedigrees. Objective/s- Evaluation The Students Will Be Able To: Students will be able to Examine examples of allele dominance Synthesize information from multiple alleles Classify common types of inheritance patterns Survey and evaluate real examples of pedigrees and Punnett squares for genetic information Solve simple blood typing problems and realize its importance Think critically about variance among populations Formative assessment through questioning gives educators a grasp on student learning. More concrete evidence of learning will be seen in student output (faces lab, case studies). This information will assist the teacher in evaluating the effectiveness of the instruction at various checkpoints in the lesson, primarily in between the two days. If time permits there will be an open discussion of the topics covered in the lesson. This could also be used as formative assessment. Kansas Science and Math Standards- Include standard, benchmark and indicator where applicable Science: (standard, benchmark, indicator) STANDARD 1: SCIENCE AS INQUIRY Grades 8-12 SCIENCE AS INQUIRY – The student will develop the abilities necessary to do scientific inquiry and develop an understanding of scientific inquiry. Benchmark 1: The student will demonstrate the abilities necessary to do scientific inquiry. The student… 4. actively engages in conducting an inquiry, formulating and revising his or her scientific explanations and models (physical, conceptual, or mathematical) using logic and evidence, and recognizing that potential alternative explanations and models should be considered. - a. engages in discussions that result in the revision of his/her explanation. STANDARD 3: LIFE SCIENCE Grades 8-12 LIFE SCIENCE – The student will develop an understanding of the cell, molecular basis of heredity, biological evolution, interdependence of organisms, matter, energy, and organization in living systems, and the behavior of organisms. Benchmark 2: The student will demonstrate an understanding of chromosomes, genes, and the molecular basis of heredity. The student … 1. ▲ understands living organisms contain DNA or RNA as their genetic material, which provides the instructions that specify the characteristics of organisms. Most cells in humans contain 23 pairs of chromosomes; the 23rd pair usually contains the XX for female or XY for male. 2. understands organisms usually have a characteristic number of chromosomes; one pair of these may determine the sex of individuals. 3. ▲ understands hereditary information is contained in genes, located in the chromosomes of each cell. - a. An inherited trait of an individual can be determined by one gene or by many genes (a polygenic trait), and a single gene can influence more than one trait. - b. The expression of traits is determined by a complex interaction of genes and the environment. - c. Alleles, which are different forms of a gene, may be dominant, recessive, or co-dominant. 4. understands gametes carry the genetic information to the next generation. - a. Gametes usually contain only one member from each chromosome pair. - b. Gametes unite to form a new individual in most organisms. 5. understands expressed mutations occur in DNA at very low rates. - a. Mutations are genetic changes and can be beneficial, neutral, or deleterious. Many mutations have deleterious effect on the organism’s survival and/or reproduction. - b. Only mutations in gametes can be passed on to offspring and thus affect future generations. Math: Must include Common Core Math Practice Standard and tested indicator (2003 standards), if applicable. Data – The student uses concepts and procedures of data analysis in a variety of situations. NINTH AND TENTH GRADES Benchmark 1: Probability – The student applies probability theory to draw conclusions, generate convincing arguments, make predictions and decisions, and analyze decisions including the use of concrete objects in a variety of situations 2. finds the conditional probability of two dependent events in an experiment, simulation, or situation (2.4.K1k) - uses theoretical or empirical probability of a simple or compound event composed of two or more simple, independent events to make predictions and analyze decisions about real-world situations including: a. work in economics, quality control, genetics, meteorology, and other areas of science (2.4.A1a); b. games (2.4.A1a); c. situations involving geometric models, e.g., spinners or dartboards (2.4.A1f). Materials list (BE SPECIFIC about quantities) Accommodations: Include a general statement and any For Whole Class: specific student needs Pack of colored pencils for each pair. (15 packs) For students with hearing disabilities a paraprofessional may have to assist them with signing what the teacher says. Case study packets (10 total, 1 each) Per Group: Faces Lab (15, 1 per pair) Case Studies (10, 1 per group) For English language learning students, the teacher may need to use more pictures on some of their worksheets. Another way to assist them is addressed by having the designated readers in each group take turns reading the problems in the assignment. Per Student: 30 pennies (for face lab) Other accommodations should be sought if need be. Advance preparation: Printing out enough copies of both the Faces Lab packet and Case study problems. Should also print out extras just in case. The extras are included in the quantities stated previously. Make sure that there is access to a room with enough space for students to spread out into small groups. Safety: Include a general statement and any specific safety concerns In order to provide the safest physical environment for these exercises students must follow the rules of the school and the classroom. All backpacks should be kept out of walking areas in order to prevent falls while students are moving around. The teacher should also keep in mind that students must feel safe psychologically as well. This can be achieved by creating an environment were being wrong is okay. Engagement: Estimated Time: 5-10 minutes What the teacher does AND how will the teacher direct students: (Directions) Day 1 Present students with the following scenario: “You are given two colors of flowering plants, red and white. What color will their F1 progeny be?” Probing Questions: Critical questions that will connect prior knowledge and create a “Need to know” Day 1 Could the colors mix? In what ways could they mix? Expected Student Responses AND Misconceptions think like a student to consider student responses INCLUDING misconceptions: Day 1 Students will probably suggest Pink Spotted Red White Another color Present real life examples where different scenarios of gene expression occur. Give the terms to the students, as these will be important for them during their explore activity. Could the progeny turn up as one of the original colors? Could the colors turn out a different color/shade altogether? There is hopefully no wrong answer given here. Even an offhand or sarcastic remark such as blue or green could be an example of epistasis, for example. Write the following terms on the board with space underneath them. Dominance Incomplete Dominance Codominance Epistasis Where do these types of gene expressions belong? Pink = incomplete dominance… Spotted = codominance… etc. Day 2 Ask students if they remember what we covered on Day 1 and try to tie it into Day 2. Day 2 Can anyone recall what we covered on Friday? Examples? Day 2 Different kinds of gene expression… Incomplete dominance/dominant vs. recessive/ codominance/etc. Begin by writing different blood types on the What do these letters represent? Blood types… The students will come up with many possible answers. Have students organize some of their answers in the categories. The teacher should do the writing to save time. white board and start asking the class if they can predict what the lesson is going to be over. Once they have a firm grasp of what the bulk of the lesson will cover begin asking them some probing questions. Students who remember from a previous lecture should be encouraged to speak up. How does an individual get a certain blood type? Can anyone explain? From their parents…. They get one of the letters from one parent and one from the other. What types of allele expression is seen in blood typing? Codominant AND dominant expression is present in blood typing. This is because the A and B alleles are equally expressed and dominant to the O allele… How is this different from expression patterns you have seen so far in this activity? We usually see just one type of expression at a time… Why is this not an example of incomplete dominance? This is not an example of incomplete dominance because that type of expression results in total mixing of alleles in a genome. (i.e. red and white parents mixing to form pink progeny). Teacher Decision Check Point: how do you know your students are ready to move forward? Students seem to think they are comfortable with the topics being discussed and are eager to keep moving on. Exploration: Estimated Time: 25-30 minutes What the teacher does AND what the teacher will direct students to do: (Directions) Probing Questions: Critical questions that will guide students to a “Common set of Experiences” Expected Student Responses AND Misconceptions think like a student to consider student responses INCLUDING misconceptions: Day 1 Well, incomplete and codominance are both examples of more complicated situations… Day 1 Pair up students based on who they are sitting next to at their desks. Day 1 What genes are more complicated than dominant/recessive? Etc. Give an overview of the lab before handing out materials. Make sure students are aware of progression of activities and results page. Can any of you explain this further or give a real life example? I have heard of cats that are called calico….. When a white chicken and a brown chicken have babies the babies are speckled with both colors… Day 2 Students are now “Expert Geneticists”. They are put into 6 groups of 4 at lab stations. Each lab station will have a copy of a specific case study. Students will need to work together to solve cases. Instruct students to write on their results page Day 2 Questions will be case study-specific. This will change from group to group depending on how far along students are in the activity. Day 2 What is MSUD? Do we have to read it all? In order to cover all the case studies as a class make sure that groups start on different cases. Cases include Autosomal Recessive (MSUD) Sex-linked recessive (Hemophilia) Codominance (blood type) Teachers will be walking around the room assisting groups that are stuck. Encourage students to spend only 5-6 minutes on each case study. It is okay is some of the groups do not complete all three of the case studies. We will go over them as a class. Teacher Decision Check Point: how do you know your students are ready to move forward? Once students have finished their activities, or when time is up. Those that did not finish will get a chance to have their peers explain their problems and solutions to them. Explanation: Estimated Time: 10-15 minutes What the teacher does AND what the teacher will direct students to do: (Directions) Day 1 Write headings on the board for the different categories Complete Dominance Codominance Incomplete Dominance Sex-linked Epistasis Polygenic Get volunteers to write some examples of each type of gene expression used in the activity. Try to get as many as possible from the activity on the board. Clarifying Questions: Critical questions that will help students “Clarify their Understanding” and introduce information related to the lesson concepts & vocabulary – check for understanding (formative assessment) Day 1 If any of the examples are miscategorized, have volunteer students explain why they are incorrectly placed. Some examples may belong in multiple categories. Day 1 Students may categorize genes from the activity in the wrong heading. Again, if this occurs, other students should be able to explain which ones are incorrect and why. What does the genotype of a sex-linked gene expression look like? What is the difference between codominance and incomplete dominance? Whether it is a blend of colors or speckled… Are polygenic genes examples of incomplete dominance? Don’t know…. No because only two alleles of a single gene affect the phenotype in incomplete dominance and multiple genes affect the phenotype of a polygenic example…. Day 2 Use questions from the case studies. If the whole class is still stuck, ask questions circumventing giving answers away. Day 2 There is a chance that groups will have incorrect answers to their case studies. If this occurs, it gives an opportunity for groups to defend their logic on how they came to the answer they did. Once the list is on the board, have students raise hands if they agree/disagree for each category. Any disagreement can be defended and explained by students, and teacher as a last resort. Day 2 Bring the attention of the class together. Start a discussion about the results of the activity. The discussion should be student driven, and the teacher should ask mainly questions. Expected Student Responses AND Misconceptions think like a student to consider student responses INCLUDING misconceptions: Teacher Decision Check Point: how do you know your students are ready to move forward? Once the genes are appropriately categorized with their gene expression. Time will also constrain progression. Elaboration: Estimated Time: What the teacher does AND what the teacher will direct students to do: (Directions) Probing Questions: Critical questions that will help students “Extend or Apply” their newly acquired concepts/skills in new Expected Student Responses AND Misconceptions think like a student to consider student responses INCLUDING misconceptions: situations Day 1: Have the students take a few minutes to explain the reasoning behind their choices for each category. Day 1: Why did you choose that one? Day 1: Because the mouth was a medium size… Explain? Student response depends on answer… If student can’t defend response have others either help explain or correct. Day2: Day 2: Day 2: Show students the blood type map: http://anthro.palomar.edu/vary/vary_3.htm What does this map make you guys think about blood typing? Begin discussion over possible outcomes of mixing blood during transfusion. Why is it important that we understand blood types? Bring up the many less known blood antigens that must be considered when blood typing outside of ABO and Rh factor. So we have covered the Rh factor in the ABO blood system of humans. Do you guys think there are other blood antigens out there? How do you think these lesser known antigens affect blood banks and transfusions? That people have lots of different types… Variation among populations… So people don’t mix bloods when donating… People with A+ can’t mix with B+…. Diego…. Indian…. Makes it more complicated…. Evaluation: Estimated Time: Built in Critical questions that ask students to demonstrate their understanding of the lesson’s performance objectives. Formative Assessment(s): In addition to the final assessment (bell ringer or exit slips), how will you determine students’ learning within this lesson: (observations, student responses/elaborations, white boards, student questions, etc. Look at your Teacher Decision Check Point)? Student questions and teacher observations are critical examples of formative assessment throughout the lesson. Likewise, it is important to re-evaluate at each checkpoint to make sure that students are not being left behind. This assessment will be held in the form of group and class discussion throughout the lesson. Teachers will move around the room during group work and discussion to ask probing questions and to check on misconceptions. These misconceptions can be discussed right away or covered as a class with the teacher facilitating the conversation as well as allowing students to learn from each other. Summative Assessment: Provide a student copy of the final assessment/exit slips or other summative assessments you use in the lesson The case study results sheets and progeny faces/results will both be measurable aspects of student assessment. This assessment will be covered in the handouts and worksheets that the students complete and turn in to the teachers.