Supplementary Table 2. Slopes of individual cognitive measures presented as group (Stable
(n=197) and Progressors (n=66)) by time (years from baseline assessment) interactions. The
estimate term represents the slope of the Progressor group compared to the Stable group as the
reference. A) Slopes for first three visits when practice effects are most pronounced. B) Slopes
across all visits. Covariates: age at baseline, gender, education, cognitive score at baseline,
and age at baseline by time interaction.
Individual Cognitive Measures
Estimate
SE
t
p
A) First Three Visits Only
WMS-R Logical Memory Immediate
-1.136
0.440
-2.583
0.010
WMS-R Logical Memory Delayed
-0.232
0.408
-0.570
0.569
FCSRT Free Recall
WMS Associate Learning
-0.259
-0.394
0.437
0.382
-0.592
-1.031
0.555
0.305
WAIS Block Design
WAIS Digit Symbol Substitution
-0.281
-0.569
0.144
0.404
-1.950
-1.405
0.053
0.162
Trailmaking Test Part A
-0.775
0.629
-1.232
0.220
Trailmaking Test Part B
WAIS Information
-1.240
-0.281
1.690
0.144
-0.732
-1.950
0.465
0.053
Boston Naming Test
Animal Naming
-0.056
0.143
0.248
0.288
-0.023
0.496
0.822
0.621
WMS Mental Control
WMS Digit Span Forward
0.131
0.015
0.094
0.062
1.39
0.242
0.165
0.809
WMS Digit Span Backward
0.073
0.069
1.065
0.288
Letter Fluency (S & P)
0.192
0.473
0.405
0.686
-0.596
-0.719
0.101
0.105
-5.894
-6.838
<0.001
<0.001
FCSRT Free Recall
-1.330
0.148
-8.993
<0.001
WMS Associate Learning
WAIS Block Design
-0.316
-0.356
0.059
0.056
-5.322
-6.355
<0.001
<0.001
WAIS Digit Symbol Substitution
Trailmaking Test Part A
-1.194
1.122
0.166
0.341
-7.179
3.582
<0.001
<0.001
Trailmaking Test Part B
WAIS Information
3.585
-0.036
0.571
0.056
6.277
-6.355
<0.001
<0.001
Boston Naming Test
-0.052
0.106
-4.868
<0.001
Animal Naming
WMS Mental Control
-0.385
-0.062
0.090
0.024
-4.292
-2.543
<0.001
0.012
WMS Digit Span Forward
-0.003
0.001
-2.237
0.032
WMS Digit Span Backward
-0.050
0.014
-3.576
<0.001
B) All Visits
WMS-R Logical Memory Immediate
WMS-R Logical Memory Delayed
Letter Fluency (S & P)
-0.789
0.139 -5.693 <0.001
Abbreviations: FCSRT = Free and Cued Selective Reminding Test, WMS-R = Wechsler Memory
Scale-Revised, WAIS = Wechsler Adult Intelligence Scale. Note: Sample sizes may vary
slightly due to missing data.