Medication Administration November 2009 CE Advocate Condell Medical Center Objectives prepared by: Mike Higgins, FF/PM Grayslake Fire Department Power point prepared by Sharon Hopkins, RN, BSN, EMT-P Objectives Upon successful completion of this module, the EMS provider will be able to: 1. Identify the six rights of drug administration correctly 2. Identify medical control’s role in drug administration 3. Identify knowledge of proper use of standard precautions 4. Identify knowledge of proper disposal of contaminated equipment 5. Identify the importance of maintaining a sterile and clean environment Objectives 6. Accurately calculate the drug dosage for a pt with weight stated in pounds, converting weight to kilograms 7. Identify the various routes used to administer medication 8. Identify the proper technique for drawing up meds from an ampule 9. Identify the proper technique for drawing up meds from a vial 10. Identify the proper administration of a medication from a prefilled syringe Objectives 11. Identify the proper administration of sublingual medications 12. Verbalize the proper administration of rectal medications 13. Identify the proper administration of IV piggy-back medications 14. Identify the proper administration of in-line nebulizer medications 15. Identify the proper administration of endotracheal medications Objectives 16. Identify proper documentation of medication administration 17. Demonstrate the proper administration of subcutaneous medications 18. Demonstrate the proper administration of intramuscular medications 19. Demonstrate proper administration of intravenous medications / IO meds 20. Demonstrate the insertion of the EZ-IO correctly 6 Right of Medication Administration The RIGHT patient In the field this is the patient lying in front of you When doing clinical in the hospital, it is extremely important to check wrist bands for identifying the right patient The RIGHT drug Check all medications 3 times prior to administration Did you grab the correct medication? 6 Rights The RIGHT dose Most field medications can be easily calculated in your head Double check if you are ever unsure of the dose The RIGHT time In the field the time is now 6 Rights The RIGHT route IV/IO Injected IM SQ Inhaled IVPB 6 Rights The RIGHT documentation Drug name Dose – verify order in mg Dose often stated in ‘amps”, “tab” Route of delivery Time administered Person administering the medication Use skill check box Patient response to the medication Allergies Important to screen all patients for their allergy status prior to medication administration If you are in doubt regarding an allergic reaction versus side effect (ie: abdominal distress), contact medical control for clarification Facts and Allergies Lidocaine and Novocain Morphine sulfate These are different “caine” families so allergy to one does not cross over to the other This is NOT a sulfa drug Lasix – furosemide There is a low risk of patients allergic to sulfa drugs having a reaction to Lasix Monitor the patient receiving Lasix if they have a sulfa allergy Medical Control You operate under the license of the Medical Director You are still individually responsible for having knowledge of the medications you are delivering Inappropriate delivery of medications, even when the patient does not suffer harm, may result in legal ramifications Medical Control Medical control is available as an on-line resource Clarification regarding indications Clarification regarding dosage Clarification regarding orders received from a physician on the scene In an acute care center, clinic, doctor’s office, you cannot accept orders unless that physician is willing to go with to the hospital Standard Precautions Establishing routes for drug administration creates the potential exposure to blood and body fluids Decrease risk of exposure by following standard precautions Gloves Goggles Mask The best standard precaution often forgotten: HANDWASHING Sterile vs Clean Environment Sterile – free from all forms of life Generally uses extensive heat or chemicals Difficult in the field to maintain sterile environments Most packages are sterile until opened Clean environment Minimize risk of infection Careful handling of equipment to prevent contamination Disposal of Equipment Minimize tasks done in a moving ambulance Immediately dispose of sharps in a sharps container Need to decrease risk of EMS exposure Rigid, puncture-resistant container Recap needles only as a last resort Use one handed technique Metric System Pharmacology’s principle system of measurement Widely used in science and medicine 3 fundamental units Grams – weight or mass Liters – volume Meters – distance To avoid use of multiple zero’s , usually change the prefixes (ie: kilo, centi, milli, micro) Drug Administration and Mathematical Skills To properly prepare and administer medications, need understanding of: Multiplication Division Fractions Decimal fractions Proportions Percentages Converting Pounds to Kilograms Many medications are dosed based on patient weight Adults – acceptable to be “close enough” Can round off the adult weight Pediatrics – must practice a more precise formula Less room for error in calculation Pounds to Kilograms 1 kilogram = 2.2 pounds In the field, usually acceptable to take the adult patient’s weight in pounds and divide in half to be close enough to the kilograms In peds, need to take the weight in pounds and divide by 2.2 Exercise Convert 150 pounds to kilograms 150/2.2 can be written as 150 2.2 As a fraction, top number (numerator) is divided by the bottom number (denominator) 150 = dividend 2.2 = divisor The divisor must always be a whole number Answer = quotient Exercise 2.2 150 Need to make 2.2 a whole number In the metric system, you are multiplying by “10” When multiplying with any derivative of 10, count the zeros and move the decimal that many numbers to the right What you do with the divisor, you must do with the dividend (actions inside and outside the box must match) Example – 150# = ? kilograms 2.2 150 = 22 1500 68.1 22 1500.0 132 180 176 40 22 18 Medication By Patient Weight Most typical order is Lidocaine (mg/kg) and pediatric drugs (mg/kg) Calculate the patient’s kilogram Divide pounds by 2.2 Acceptable to divide the adult weight by 2 Multiply the kilogram by the number of mg per kilogram Then you need to calculate the volume (ml) to draw up in the syringe Example Give your 132 pound patient 1.5mg/kg Lidocaine Lidocaine is packaged as 100 mg/5ml Steps to calculate Convert pounds to kilograms Based on the kilograms, calculate the number of mg required Multiply kilograms by mg/kg required Calculate the ml volume to draw up Answer 132 2.2 = 1320 22 = 60 kg 1.5 mg/kg = 1.5 mg x 60 kg = 90mg Now, draw up 90 mg (Lidocaine comes 100 mg/5ml) Formula #1: x ml = desired dose x vol on hand dose on hand Formula #2: mg in bottle = mg ordered ml in bottle x ml Formula #1 Formula #1: x ml = desired dose x vol on hand dose on hand x ml = 90 mg x 5 ml 100 mg x ml = 450 (this fraction means 450 100) 100 (top number divided by bottom number) x ml = 4.5 ml Formula #2 Formula #2: mg in bottle = mg ordered ml in bottle x ml 100 mg = 90 mg 5 ml x ml (cross multiply) 100 x = 450 (divide by 100 to get 100 x = 450 x by itself) 100 100 (divide top by bottom #) 450 / 100 = 450100 4.5 ml is answer Do Brain Check Give 90 mg Lidocaine Lidocaine packaged 100 mg / 5 ml Your answer was to give 4.5 ml Brain check 90 mg is slightly smaller than the total amount of 100 mg 4.5 ml is slightly smaller than 5 ml So our math must be correct Routes of Medication Administration 4 basic categories Percutaneous Pulmonary Absorbed via inhalation or injection Enteral Applied or absorbed thru the skin Absorbed thru the gastrointestinal (GI) tract Parenteral Administration outside the GI tract Generally includes the use of needles Percutaneous Medication Routes Meds absorbed through skin or mucous membranes Sublingual route Medication absorbed through the mucous membrane under the tongue Sub = below; lingual = tongue Area extremely vascular Moderate to rapid rate of absorption Avoids the digestive tract Mucous Membranes cont’d Nasal route Uses a medication atomization device (MAD) Coming soon to Region X Relatively rapid absorption rate in the absence of IV access MAD provides a fine mist that allows even and widespread distribution of medication across the nasal mucosa The Region is preparing to incorporate use of the MAD device in the near future Pulmonary Medication Route To administer medications into the pulmonary system via inhalation or injection Generally include gases, fine mists, or liquids Most medications used for bronchodilation for respiratory emergencies Inhalation also used for humidification Nebulizer Uses pressurized oxygen to disperse a liquid into a fine aerosol spray or mist Inhalation carries the aerosol to the lungs Enteral Route - Rectally Medication absorbed through the GI tract Extreme vascularity promotes rapid drug absorption Absorption more predictable Medications administered rectally do not pass through the liver so are not subject to alteration in the liver Advantageous for the unconscious patient Parenteral Route Any drug administration outside of the GI tract Typically, this route involves the use of needles Medication is injected into the circulation or into tissues Some parenteral forms (ie: IVP) are the most rapid for drug delivery Syringes Plastic or glass tube for drawing up medications Range of sizes Medications are given in dosages by weight (ie: mg) Syringes represent volume (ie: ml) Weights (ie: mg) must be mathematically converted to volume (ie: ml) Syringe Markings Plunger Barrel Hash marks Use most appropriate sized syringe for higher accuracy TB Syringe Medications in Ampules Breakable vessel with liquid medication Cone-shaped top with thin neck Thin neck is the vulnerable point for intentionally breaking open the ampule Contains a single dose of med Withdrawing From an Ampule Confirm the medication and dosage Hold the ampule upright Tap the top to dislodge trapped liquid Place gauze (or alcohol wipe package) around thin nick Snap top off away from you Place tip of needle into ampule and withdraw liquid Dispose of ampule into sharps container Medications in Vials Plastic or glass containers with self-sealing rubber top Rubber top prevents leakage from punctures May contain single or multiple doses Liquid is vacuum packaged Withdrawing From a Vial Confirm the medication and dosage Prepare the syringe and needle based on volume of liquid to draw up Use 1 ml TB syringe for any dose < 1 ml Because of the vacuum, draw up the same amount of air as volume to be removed Cleanse rubber top with an alcohol wipe Insert needle straight into rubber top Vial cont’d Inject the air from the syringe into the vial Withdraw the desired volume of liquid Watch to keep tip of needle in liquid Helpful to draw a small amount of extra fluid to accommodate removing air bubbles Hold syringe with needle pointing upward Tap side of syringe with finger to displace bubbles to distal end of syringe Expel air bubbles and confirm exact volume required in syringe Medications in Prefilled Syringes Tamperproof containers packaged with medication already in the syringe Generally contain standard dosages May require assembly Prefilled Syringe Confirm the medication and dosage Assemble syringe Pop off protective caps Twist glass tube containing into syringe Glass tube becomes the plunger Expel excess air Confirm dosage volume required Lidocaine cap is twisted to unlock and then remove the cap liquid Nonconstituted Medications Extends viability and storage of time for drugs with short shelf life or instability in liquid form Consists of 2 vials Powdered medication Liquid mixing solution Reconstituting Medications Confirm medication and dosage Prepare syringe with liquid Cleanse off top of powder vial Inject liquid into powder vial Gently roll vial between palms to dilute powder Check that ALL particles have dissolved Redraw up liquid into syringe, expel excess air Medication Administration Medication Administration Just because you administer medications now, does not mean your technique is accurate The first rule in medicine: Primum non Nocere Hippocrates First, do no harm! Sublingual Medication Route Use Standard Precautions Confirm medication and dosage 3 times Have patient lift their tongue Place the tablet between the tongue and the floor of the oral cavity Instruct the patient to allow the pill to dissolve In-line Nebulizer Administration Route For administration of Albuterol when the patient is no longer able to ventilate effectively to inhale the medication into their lungs Can begin to bag the patient and force the medication into the lungs even prior to intubation Set the equipment up and ventilate via a mask while waiting for intubation Endotracheal Administration Route Discouraged route but not forbidden Studies have failed to demonstrate adequate absorption of medication via this route If used, double the calculated IVP dosage Hyperventilate to distribute the medication Acceptable for: Lidocaine, Epinephrine, Atropine, and Narcan (ie: LEAN) Rectal Medication Confirm medication and dosage 3 times Via syringe Use a small diameter syringe based on size of patient Lubricate tip of syringe Turn the patient onto their side Insert tip of syringe into rectum Inject medication Remove syringe and hold cheeks together Permits retention and absorption Rectal Administration Via IV catheter In place of a syringe tip being placed into the rectum, can place an IV catheter on the needleless syringe and then inject the medication Reduces the diameter of the equipment used Helpful alternative especially in the pediatric population Parenteral Medication Routes Intradermal injection Subcutaneous injection Intramuscular injection Intravenous injection Intraosseous injection Preparing The Syringe Pull medication into the syringe Tap the side of the barrel to displace air bubbles to the distal tip Express out the excess air bubbles Confirm accuracy of medication dosage Rubber edge of the plunger lines up with the dosage marking on the barrel Then draw up an additional 0.1 ml of air for SQ or IM injections The air plug pushes the med farther into the site preventing leakage of med Preparing the Site Wipe the intended site with alcohol Start wiping from the center moving outward Let the site air dry Introducing alcohol into the site causes irritation Do not blow on the site to hasten drying – causes contamination SQ Route Layer of connective tissue between skin and muscle Less blood supply than IM so slower absorption rate Slow onset of action but long duration of drug action due to less blood supply Maximum volume of medication is 1 ml Preferred needle size is 25 – 27 G; 3/8 - 5/8 inch Preferred is 450 angle (900 angle acceptable if using ½ inch needle) Subcutaneous Medication Routes Sites Deltoid Abdominal Thighs Buttocks SQ Technique Prepare the syringe and needle Identify the site Cleanse the site Pinch a fold of skin up Quickly dart the needle into the fold at a 450 angle 900 angle is an alternative especially with ½” needle Release the fold Aspirate checking for blood return Inject steadily Quickly withdraw the needle and discard Massage the site to enhance absorption Aspiration Before Injection Purpose To check for inadvertent entry into a vessel If you did not check you could be giving an IVP drug instead of a SQ or IM More common for vessel entry during an IM If blood is returned, remove needle and prepare a new syringe and needle Pediatric SQ Injections Most common site is posterior upper arm Next site used is the anterior aspect of the thigh Limited volume up to 1 ml of volume SQ Use 450 angle injected into pinched skin Site has limited use in poor perfusion state IM Route Muscle is extremely vascular and allows for systemic delivery throughout the whole body and a moderate absorption rate Absorption is relatively predictable When using the buttock, important to avoid the sciatic nerve If you strike the sciatic nerve, the patient could develop chronic pain Typical needle size is 21 – 23 G; 1 – 11/2” Use 900 angle Volume limitation dependent on the site used Intramuscular Medication Route Sites Deltoid Buttock Dorsal gluteal Ventrogluteal Thigh Vastus lateralis Rectus femoris IM Sites Deltoid Easily reached Smaller sized muscle limits volume used 2 ml maximum Site is 2 - 3 finger breadths below the acromial process (AC) and above the armpit crease Area often identified as a triangle IM routes cont’d Buttocks – dorsal gluteal Can inject up to 5 ml Minimal discomfort felt Must stay away from the sciatic nerve Avoid this site in kids < 2 and in emaciated patients Find the site in the upper, outer quadrant of the buttock Must avoid the sciatic nerve IM site cont’d - Ventrogluteal Volume 1 – 3 ml Good site for children <7months Place the palm over the trochanter of the femur Make a V with the 2nd and 3rd fingers The 3rd finger runs straight up to the iliac crest The 2nd finger angles forward to the anterior superior iliac crest The injection is made inside the V formed between the 2nd and 3rd fingers IM routes cont’d Thigh Vastus lateralis – side of the thigh Rectus femoris – muscle over the front of the thigh Can inject up to 5 ml volume Practice often is to divide larger volumes into 2 injections of smaller volume Thigh Injection Site To find the site Place one hand at the top of the thigh at the groin Place one hand on the distal (lower) thigh above the knee The area between the 2 hands can be used Anterior surface of the thigh at the midline is the rectus femoris Lateral to the midline is the vastus lateralis Pediatric IM Injection Thigh is preferred site in peds Especially used in infants and young toddlers Large muscle mass No proximal nerves or blood vessels Limited subcutaneous fat layer More developed muscle than other sites Can accommodate larger volumes than other pediatric injection sites IM Technique Prepare syringe and needle Identify site Prepare site – let alcohol air dry Pull the skin taut Dart the needle in at 900 The quicker the dart like insertion, the less painful Slowly and steadily inject the medication Quickly withdraw needle and properly discard Massage site – enhances absorption Intravenous Administration Route Quickest route to deliver medication directly into the bloodstream Fastest absorption rate Dependent on adequate perfusion Many medications are in prefilled syringes Pop off protective caps Assemble syringe Expel air Confirm dosage Administer medication Watch for response IVP Medication Confirm medication 3 times for accuracy Prepare syringe Consider need for a flush Secure medication syringe into an IV port as close to the IV site as possible Pinch off the IV tubing Inject the medication at the prescribed speed for the medication Needleless IV Tubing Standard IV tubing to minimize the event of needle stick Port wiped with alcohol Needle twisted onto port Must pinch tubing above injection site Fluid will move in direction of least resistance IVPB Administration Route To administer a medication over a longer period of time All IV bags hanging need to be labeled The bags can be hung at the same height The IV bags will both drip independently of the other IV bag Secure the IVPB into a port as close to the IV site as possible Disposal of Contaminated Equipment As soon as possible dispose of equipment into sharps container After giving an injection, snap the protective cover over the needle After starting the IV, the needle should be covered as it is retracted after the injection Side Effects and Complications Remember for all injections Once delivered, cannot get the medication back Be very sure of 5 “rights’ Patient Drug Dose Route Time Once administered, monitor for known side effects and any other changes to the patient Documentation of Medication Administration Time Drug name Drug dosage in mg Route Patient response EZ-IO Indications Shock, arrest, impending arrest Unconscious/unresponsive to verbal stimuli 2 unsuccessful IV attempts or 90 seconds duration of a peripheral attempt EZ IO Contraindications Fracture of the tibia or femur Infection at insertion site Previous orthopedic procedure Knee replacement Previous IO within 48 hours Pre-existing medical condition Tumor near site, peripheral vascular disease Inability to locate landmarks Excessive tissue at insertion site EZ IO Needles Adult patients 88 pounds or over (40 kg) 15 G; 25 mm blue needle Pediatric patients 7 - 88 pounds (3 kg – 39 kg) 15 G; 15 mm pink needle Think “pink” for “peds” EZ IO Equipment 10 ml syringe filled with 0.9 NS 5 ml of NS in syringe for peds patient EZ connect tubing Material to cleanse site EZ IO driver EZ IO needle in it’s case Primed IV tubing 1000 ml bag for adults 250 ml IV bag for geriatric and pediatric patients Pressure bag (B/P cuff is no pressure bag) EZ IO drill with storage case EZ IO Site Most common site: proximal tibia Palpate the tibial tuberosity Bump below the patella Identify 2-3 finger widths below the patella Move 1 finger width medially (toward the big toe) In smaller children often will not be able to palpate the tibial tuberosity EZ IO - Technique Prime EZ connect tubing Takes 1 ml to prime tubing Leave syringe attached Attach needle to driver Insert needle at 900 angle into site Release trigger once decreased resistance is felt Remove driver from needle Remove stylet by rotating counterclockwise EZ IO Technique cont’d Connect EZ primed tubing to needle May notice backflow of bone marrow Blood will NOT pump out of needle Using syringe, aspirate then flush with remaining NS to confirm placement Needle stands up on own Flushes easily No infiltration felt EZ IO Technique cont’d Remove syringe Attach primed IV tubing Secure pressure bag to permit flow of fluid Begin infusion Secure tubing to leg Apply wristband Monitor site for infiltration Can administer any IVP medication that would normally be given IV push EZ IO Documentation Same information for starting an IV Time Solution Size IV bag Site Person actually performing the puncture Case Study #1 Your patient weighs 150 pounds They need to receive 1.5 mg / kg Lidocaine Lidocaine packaged as 100 mg/5 ml How much Lidocaine needs to be drawn up and given? Case Study #1 Calculate pounds to kilograms Calculate total mg of medication 150 2.2 = 68.1 rounded to 68 kg To receive 1.5 mg per kg Multiply 1.5 x 68 = 102mg Calculate how much medication to deliver Use formula of your choice Case Study #1 Formula #1 X ml = desired dose x vol on hand dose on hand X ml = 102 mg x 5 ml 100mg X ml = 510 100 X ml = 510 100 X ml = 5.1 ml (in the adult rounded to 5 ml) Case Study #1 Formula #2 100 mg 5 ml 100 x 100x 100 x X = 102 mg x ml = 510 = 510 100 = 510 100 = 5.1 ml (rounded to 5 ml) Case Study #2 Your 45 year-old patient is having an allergic reaction with airway involvement The vital signs are stable What medications are indicated? How do you administer each of the medications? Case Study #2 Epinephrine 1:1000 – 0.3 mg SQ Bronchodilator, vasoconstrictor Short needle (3/8 - 5/8”) 450 angle Pinch up the skin Benadryl 50 mg IVP slowly or IM Antihistamine Long needle (1” up to 1 1/2”) 900 angle Pull the skin taut before injecting Case Study #2 Always aspirate to check for inadvertent entry into a vein If blood is noted, withdraw needle Prepare a new needle and syringe Injecting the blood can cause irritation With blood in the syringe, may not be able to detect aspiration of new blood at new site Case Study #3 You are on the scene of a full arrest You cannot find peripheral veins What is you next alternative? How do you confirm needle placement? Case Study #3 EZ IO needle is indicated Confirmation of needle placement Needle stands up by itself Able to flush the needle easily through the EZ connect tubing Fluid flows with a pressure bag attached No infiltration is noted EZ IO Needle Needle always flushed via the EZ connect tubing NEVER flush the needle directly – too much pressure Case Study #4 You have an 8 month-old infant with a blood sugar of 45 The patient responds weakly to verbal stimuli What medication is necessary? How do you prepare the medication? How do you administer the medication? Case Study #4 - Hypoglycemia Ages > 16 – Dextrose 50% Ages 1 – 15 – Dextrose 25% Age < 1 years-old - Dextrose 12.5% Diluted strength due to vein irritation Calculate the dosage Draw up equal amounts normal saline and D25% to make a 1:1 dilution Administer slowly due to vein irritation Case Study #4 Dextrose is given IVP Wipe off the injection port with alcohol Push on the needleless syringe and twist to connect Pinch off the tubing above the injection port Slowly and steadily administer the medication Evaluate the site for infiltration Evaluate the patient’s response Case Study #5 You are on the scene for a 5 year old having a seizure Patient weighs 50 pounds History of seizure disorder Glucose level of 80 You are unable to establish a peripheral IV What do you do for the airway? What medication is indicated? How do you administer the medication? Case Study #5 Airway control – bag the patient In active seizure, the respiratory status of the patient is difficult to evaluate and assume the patient is not ventilating well Medication and route Valium 0.5 mg/kg (max 10 mg) rectally Case Study #5 Calculate dose 50 pounds 2.2 = 22.7 = 23 kg Multiple 0.5 mg x 23 kg = 11.5 mg = 12 mg Max dose is 10 mg Valium comes 10 mg per 2 ml Make sure syringe is needleless Insert syringe into buttocks Inject medication and remove syringe Hold cheeks together Pediatric Resources What resources are available to calculate a pediatric dosage? Back of the SOP’s Medical Control Broselow tape Valium listed as diazepam Narcan listed as Naloxone Normal saline listed as crystalloid Bibliography Bledsoe, B., Clayden, D., Papa, F. Prehospital Emergency Pharmacology 5th Edition. Brady. 2001. Bledsoe, B., Porter, R., Cherry, R., Paramedic Care: Principles and Practices. Brady. 2009 Edmunds, M. Introduction to clinical Pharmacology. Elsevier. 2006. Marenson, D. Pediatric Prehospital Care. Brady. 2002. Region X SOP’s March 2007, Amended January 1, 2008 Sanders, M. Paramedic Textbook. Rev 3rd edition. Mosby. 2007 wps.prenhall.com www.vidacare.com