RBHraCaNacRkkm<úCa Cati sasna RBHmhakSRt Technical School for Medical Care BIOLOGY RTwsþIekasika (The Cell Theory) Kim Sorya BBA, MD, MPH Email: drkimsorya@yahoo.com Tel: 012 955 008 1 karBitmYycMnYnGMBIekasika (Some Random Cell Facts) mnusSmaDmFümmñak;pSMeLIgBIekasikaRb Ehl 100 Trillion . The average human being is composed of around 100 Trillion individual cells!!! 100,000,000,000,000 edIm,IbegáIt)ancMnuccucmYyenAelIGkSr “i” RtUvkarekasikaRbEhl 50 It would take as many as 50 cells to cover the area of a dot on the letter “i” WOW!!! 2 rbkKMehIjekasika (Discovery of Cells) rbkKMehIjekasika nigrcnasm<½n§rbs;va KWCab;Tak;TgnwgkarbegáItEkvBRgIk CaBiessmIRkUTsSn_ (The discovery of cells and their structure is linked 3 rbkKMehIjekasika (Discovery of Cells) qñaM 1665 GñkviTüasaRsþCnCatiGg;eKøseQµaH rU:bWth‘uk (Robert Hooke) )anrkeXIj nigbegáItBaküekasika enAeBlKat;BinitüemIlceRmokeQImüa:gRsaldUcesñar. Kat;BN’naekasikafaCaRbGb;tUc b¤sMbukXµúM (honeycomb) Kat;KitfaekasikamanEtenAkñúgrukçCatinigBBYkpSit (He thought that cells only existed in plants and fungi) 4 Anton van Leuwenhoek enAqñaM 1673 )aneRbIR)as;mIRkUTsSn_eFVIedayédedIm,IsegátBinitüe mIlBBuHTwkføúk ehIy)anrkeXIjsarBagÁkayEdlpSMeLIgBIekasikaEtmYy (single-celled organisms) Kat;ehABYkvafa “animalcules” Kat;k¾)ansegáteXIjekasikaQamrbs;RtI bkSI kEgáb Eqá nigmnusSpgEdr. dUecñH eKdwgfaekasikaRtUv)anrkeXIjenAkñúgstVk¾dUcCaruk 5 karxVHcenøaHry³eBl 150-200 qñaM (150-200 Year Gap???) cenøaHrvagrbkKMehIjrbs; Hooke/Leuwenhoek nigBak;kNþalstvtSTI 19 mankareCOnelOneTAmuxtictYcbMputTak;Tgekasi ka. Between the Hooke/Leuwenhoek discoveries and the mid 19th century, very little cell advancements were made. enHRbEhlmkBICMenOeTAelIkMeNItedayÉkÉg (spontaneous generation) EdleK)anTTYlykya:gTUlMTUlay. Examples: kNþúrekItecjmkBIknÞb¼knÞk; - 6 kareCOnelOnenAstvtSTI 19 (19 th Century Advancement) karsgS½yCaeRcInekItmanenACuMvijRTwsþIénkM eNItedayÉkÉg cugeRkayRtUv)anbgðaj[eXIjfaminBiteday Louis Pasteur: Ummm, I Pasteur. don’t think so!!! ? = + 7 karbegáItRTwsþIekasika (Development of Cell Theory) qñaM 1838 – rukçviTUCnCatiGalWm:geQµaH )anTajesckþI snñidæanfaEpñkénrukçCatiTaMgGs;KWekIteLIgBIe kasika. 1838- German Botanist, Matthias Schleiden, Matthias Schleiden concluded that all plant parts are made of cells 8 karbegáItRTwsþIekasika (Development of Cell Theory) qñaM 1839 – srIr³viTUCnCatiGalWm:geQµaH EdlCamitþ rbs; Schleiden )anEføgfaCalikastVTaMgGs;pSMeLIgBIekasika. Theodor Schwann 1839- German physiologist, Theodor Schwann, who was a close friend of Schleiden, stated that all animal tissues are composed of cells (all animals are made of cells). 9 karbegáItRTwsþIekasika (Development of Cell Theory) qñaM 1858 – elak Rudolf Virchow EdlCaRKUeBTüCnCatiGalWm:g;/ bnÞab;BI eFVIkarsikSaCaeRcInGMBIeraKsaRsþekasika/ )anTajesckþIsnñidæanfaekasikaRtUv EtekItecjBIekasikaEdlmanRsab; ¬ekasikaekItecjEtBIekasikaEdlman Rsab;¦ . (cells must arise from preexisting cells or cells can only arise from preexisting cells). 10 karbegáItRTwsþIekasika (Development of Cell Theory) qñaM 1862 – elak Louis Pasteur )anpþl;PsþútagGMBITsSnHEdlfaKµankar begáItekasikaedayÉkÉgecjBIrUbFatuKµanCIvitena HeT/ edayeFVIBiesaFn_KMrUdUc teTA (1862-Louis Pasteur provided proof of the idea that there was no spontaneous creation of cells from non-living matter, with the following classic experiment). 11 BiesaFn_rbs;)a:sÞ½r (Pasteur's Experiment) Twksu‘bEdlmansarCaticiBa©wmRtUv)andut kMedA nigsMlab;emeraKGs; enAkñúgdbEdlmankRtg; nigdbEdlmankekag (Nutrient broths were heated and sterilized in a flask with a straight neck and a curved neck). 12 BiesaFn_rbs;)a:sÞ½r (Pasteur's Experiment) )a:sÞ½reRbIR)as;dbEdlmankRtg;/ CaRkumepÞógpÞat;/ EdlGnuBaØat[)ak;etrIcUl eTAdl;kñúgTwksu‘b. enAkñúgdbTaMgenH )ak;etrIduHlUtlas;enAkñúgTwksu‘bya:g qab;rh½s. dbBiesaFn_rbs;)a:sÞ½rmankEvgragCaGkSr S. CamYynwgkRbePTenH emeraK minGaccUleTA)an eTaHbICadbTaMgenHRtUveKdak;[RtUvxül;k¾eda y. dUecñH Kµan )ak;etrIduHlUtlas;enaHeT. 13 14 RTwsþIekasika)ancb;sBVRKb; (Cell Theory Complete) smasFatumUldæan 3 énRTwsþIekasika)aneBjeljsBVéf¶enH ³ 1> sarBagÁkay¼Pav³rs;TaMgGs;pSMeLIg¼ekIteLIgBIe kasikamYyb¤eRcIn All organisms/living things are composed/made of one or more cells). (Schleiden & Schwann)(1838-39). 2> ekasikaKWCaÉktarcnasm<½n§nigmuxgarénCIvitkñ úgRKb;Pav³rs;TaMgGs; The cell is the basic structural and 15 RTwsþIekasikasm½yTMenIb (Modern Cell Theory) RTwsþIekasikasm½yTMenIbmanpÞúkesckþIEføgc MnYn 4 bEnßmeTAelIRTwsþIekasika edIm ³ ekasikamanpÞúkBt’mantMnrBUCEdlRtUv)anepÞrEck BIekasikamYyeTAekasikamYykñúgGMLúgénkareFVIc MEnkekasika. The cell contains hereditary information(DNA) which is passed on from cell to cell during cell division. ekasikaTaMgGs;mansmasPaBKImI nigskmµPaBemtabUlIsCamUldæandUcKña. All cells are basically the same in chemical composition and metabolic activities. 16 RTwsþIekasikasm½yTMenIb (Modern Cell Theory) RTwsþIekasikasm½yTMenIbmanpÞúkesckþIEføgc MnYn 4 bEnßmeTAelIRTwsþIekasika edIm ³ RKb;muxgarsrIr³saRsþnigKImICamUldæan RtUv)aneFVIeLIgenAkñúgekasika ¬clna/ karrMlayGahar >> CaedIm¦. All basic chemical & physiological functions are carried out inside the cells.(movement, digestion, etc) skmµPaBekasikaGaRs½yeTAelIskmµPaBrbs;rcnasm< ½n§GnuekasikaEdlzitenA kñúgekasika ¬srIragÁÉkeTstUc²/ éNVyU:/ Pñasekasika>>¦. Cell activity depends on the activities of sub-cellular structures within the cell (organelles, nucleus, plasma membrane) 17 þc? (How has the cell theory been used) karBitCamUldæanEdleK)anrkeXIjGMBIekasika/ EdlmanrayenAkñúgRTwsþIeka sika/ KWCamUldæanénkargardUcCa ³ karBüa)alnigRsavRCavCm¶W¼suxPaB¼evC¢saRsþ ¬eGds_/ mharIk/ va:k;saMg/ kar bgáat;køÚn >>.l.¦ 18 References Understanding biology, Third Edition, 1995, By Peter H. Raven and George B. Johnson. www.biology-online.com 19