Risk Assessment for Methyl Isocyanate Inhalation

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Background:

“Medical Mystery”

Case study #1:

10yr old Active, healthy male

SYMPTOMS:

General Malaise, always in pain, joints hurt, developed Juvenile

Arthritis

Severe headaches; unable to attend school

Extremely tired, drowsiness, apathy and general weakness

Loss of appetite, losing weight; when ate food/water got severe stomach cramps

Lost urge to thrive, listless, just laid in bed all day

Blood work: elevated TA1 cells , decreased B lymocytes, markers for autobodies rheumatoid arthritis markers

Result:

Saw 9 specialists at Children's and UW : “flu”

Risk Assessment for the

Exposure to Isocyanates (in carpets)

Isocyanate Monitoring System

What are Isocyanates?

Where they’re found:

The Compound

Isocyanate molecules have the functional group -N=C=O.

Carpets (newly installed)

Upholstery

Foam

Mattresses

Paints/Auto finish

Surface coatings (laminates)

Adhesives

Dream HOME ?

“I wanted the house to be so nice, and then I poisoned my son with it.”

Partial list of Some of the Over 200

Chemicals Found in Manufactured Carpet

(provided by a carpet manufacturer)

 ethylbenzene formaldehyde methacrylate acid methyl methacrylate acrylic oligomers tetrachloroethylene toluene xylenes

4-phenylcyclohexene acetonitrile azulene benzene biphenyl

2-butyloctanol-1 cyclopentadiene-ethenyl-

2-ethylene

1,3,5-cycloheptatriene

1-chloronaphthalene diphenyl ether dodecane

1,4dihydroxyacenophthene ethylxylene

1-ethyl-3-methylbenzene hexadecanol hexamethylene triamine

1-h-indene

1-methylnaphthalene

2-methylnaphthalene

1-methyl-3 propylbenzene

2-methyl-4-tridecene

5-methyltridecane octadecenyl amine (oleylamine) oxarium polyacrylates

1-phenylcyclopentanol

2-propylheptanol phthalic esters styrene

1,2,3,-trimethylbenzene

1,2,4,-trimethylbenzene tetradecene

2,3,7-trimethyldecane undecane,2,6-dimethyl

*By selecting Green Label Plus carpet or adhesive, you are assured one of the lowest emitting products on the market, and you may be able to earn LEED or

Green Guide for Health Care points.

!! HAZARDS!!

Symptoms associated with exposure to the chemicals

(provided by industrial hygienists)

• eye irritation throat cancer blurred vision eyes sensitive to light throat irritation loss of voice cough dry or thirsty mouth lips burning tongue burning nose burning or bleeding loss or increase of smell moodiness respiratory tract irritation

• rash or itching

• hair loss

• weight loss or gain

• flu-like symptoms

• aggravated asthma

• aggravated allergies

• joint pain

• muscular aches

• abdominal pain

• memory loss

• poor concentration

• nervous system disorders

• unusual depression

• Irritability

• headaches

• dizziness,

• disorientation

• vomiting

• nausea

• chest pains

• shortness of breath

• irregular heart beat

• high blood pressure

• drowsiness

• unusual fatigue

• chemical sensitivity

• jerking in sleep

• menstrual irregularities

• sexual dysfunction

Chemical

Benzene, formaldehyde, ethyl benzene, styrene, acetone

Health Effects

CANCER

4-PC (used in the latex backing of

95% of US carpets)

Scotchgard (perflouro-octanyl salphonate)

Eye, nose and upper respiratory problems

Reproductive problems in rats

Naphthalene (mothproofing chemicals) Produce toxic reactions, especially in newborns

PBDE’s (fire retardants) Damage to thyroid, immune system and brain development functions in humans

Bhopal, India

Catastrophic Chemical Leak and Explosion

Bhopal, India Gas Leak Disaster 1984

Cauldron of Chemical Soup

Toxic “ Cocktail ”

BENZENE

C-8 acetonitrile

PFC’ s

Isocyanates

PFOA

P.B.D.E.

Micron(pesticide)

Case study #2:

Mr. Braithwaite:

-Started laying carpets at 10 with father

-Disabled at 39 yrs. old

-Father died of lung cancer at 58

Symptoms:

-severe concentration problems

-memory loss

-ringing in his ears

-erratic heartbeats

-shortness of breath

-recurring nosebleeds

-coordination problems

-gastrointestinal problems

-numbness in lower arms/hands.

Neurological testing:

-SPECT scan verified damage to his brain

- Doctors convinced solvents/other chemicals in carpets/glues he worked with are cause

Case Study #2: (cont.)

• Dad died of lung cancer when he was 58

• Another carpet layer, a good friend died same way

• Many carpet layers in our area died of cancer

• Developed other serious health problems when they were relatively young

"I want to know the names of all the chemicals I have been working with for the past twenty plus years. I should have a legal right to know what has been poisoning me," he says. "I want to know why I was never given any warnings about any of this all the years I laid carpet.

•how many other families?

• how many little children made seriously ill?

•before the CRI honestly admits to the problem and stops putting out products that place people at risk?“

Case Study #3:

Exposure: foam mattress

• Worked at a foam mattress factory, the chemicals used are quite nasty

• Main chemical to worry about: TDI, which I believe is from the isocyanate family

• Remnants of this chemical remain in the mattress

• Have regular drills in case of a spill or a leakage. The gas given off by this chemical was odorless and lethal

• Carry a gas mask

• Sirens during leakage

• 100 yards long ventilation warehouse, emergency exits every 10 yards to escape!!

http://cr4.globalspec.com/thread/3496/Memory-Foam-or-Foamy-Memory

Case Study #4

10 month boy, Christopher, on the carpet.

• Went into strange seizure-like reaction

• Upper body tensed up, arms started shaking, and his jaw moved awkwardly

• Doctors ruled out multiple sclerosis, muscular dystrophy, and tumors

• "tremors of unknown origin"

• Doctors tried drugs but didn't stop the tremors.

Parents had carpet tested in a lab: “the mice were rolling over and shaking just like Christopher

Ripped out the carpet, the tremors stopped.

Testing on Christopher showed:

• Immune system damage consistent with chemicals exposure,

• Autoimmune disease, myelin in his nervous system -- a sign of nerve tissue damage

Risk Assessment

Chronic Human Respiratory and

Immune Exposure to Isocyanates

Isocyanates Inhalation Exposure

Human

Immune

NOAEL.

.0006ppm

=

.oo14mg

Human

Resp.

NOAEL

.0002ppm

=.0061 mg/m 3

Conversions for human Inhalation

Exposure

1 ppm = 2.34 mg/m 3

1 mg/m

3

= .4274 ppm

Example:

LOAEL for respiratory system is .0006ppm

.0006ppm x 1mg/m

3

/.4274 ppm =.0014mg/m

3

Assessment/Exposures

: using BioMarkers notes from Dr.Costa’s lecture Feb 10, 2010

Adverse Affects:

• Nervous system, O

2 and glucose requirements

• Memory loss

• Cognitive Impairment

Humans now have this “ neurotox index”. Neurotoxins affect cell to cell interaction biomarkers: Polymorphisms

On cell surface have structures made out of glycoprotein, that after toxic exposures: have missing parts . If our body can not replace those missing parts (called glyconutrients) then it destroys those structures. This is what causes “ auto-immune ”

(where body attacks itself). It’s a response that a lot of people have and most carpet layers have.

• sugars that a stressed body can’t make, then have to come from our food, which can be depleted of these sugars. (Castor).

• Mannose is one of those key sugars, our body uses to repair and restore the cellcell communication. Stop body self-destruction, or auto immune response } .

• 5 of the 8 necessary sugars are present in human breast milk .

* Manifests: chronic fatigue, lupus, fibromyalgia, brain fog, severe headaches,

Multiple chemical sensitivities (MCS), hearing loss, memory loss (see symptom list)

Study of Glycobiology

One solution of toxic exposures

"Carbohydrates are the glue that pulls things together, the cell surface matrix in which cells communicate, and they provide the connections for signal transduction. It's only been within the last decade that we've realized that such structures are critical for all kinds of biological function."

ScienceDaily.com- May 15, 2008

In 1996 Harper's Biochemistry, a medical text, introduced "the eight principal sugars found in human

glycoproteins." Eight specific sugars were identified on human cell surface glycoforms which are involved in cellular recognition processes.

Precautionary Risk Assessment

Hazard, Community, Exposure Issues

Parameter

Community/Social Issues

Score

G = Goal

N = Need

3 – does NOT move forward the goal of human and environmental health

3 – we do NOT need this

F = Future generations

D = Democratic community based process

A = Alternatives

Total

3 – there is VERY HIGH potential impact on future generations

3 – hardly anyone knows about the risks and hazards

3 – some companies switched out formaldehyde for isocyanates...

15/15

– NOT SUPPORTIVE OF

HEALTH OR COMMUNITY

Parameters

E = Exposure

M = Multiple exposure

Ch = Children exposed

CP = Consumer products

Exposure Issues

Score

O = Occupational exposure

1 – we have LITTLE control over exposure from carpets

3 – very WIDE range of chemicals in carpets

5 – children, especially infants are at the greatest risk, in their breathing zone

3 – carpets are in almost every home/work place, and many other products

3 – insocyanates are everywhere

F = Food exposure

Total

0 – not found in food

15/20 – serious concern

Parameters

Hazard/Toxicity Issues

Score

Hazard 10 – very toxic, very hazardous

Individual sensitivity

Ecological hazard

Volume

3 – young children, infants sick within a couple hours

3 – same health effects seen in mammalian studies

5 – extreme concentrations

Persistent

Bioaccumulation

Uncertainty

Total

3 – stays around

2 – some, most neurotoxins

2 – not very much official research, but many real-life case studies

28/30 – LIKE SO

HAZARDOUS!!

COVER UP by the CRI

(Carpet Rug Institute)

" The carpet industry has mounted a massively deceptive merchandising campaign that intentionally mislead the public by implying that all carpets with the green tag

have met safety standards," says New York Attorney General Robert Abrams . He had petitioned CPSC( Consumer Product Safety Commission ) to require warning labels on carpets.

Because of the large number of carpet complaints, the attorneys general of twenty-five other states signed the petition as well. (9) CPSC refused to even consider their petition.

• there are no such recognized standards of safety. The Carpet and Rug Institute its own arbitrary standards.

• CRI's testing program is completely inadequate because it measures only a small percentage of the chemicals emitted from carpets.

• a manufacturer can get a green tag for an entire product line simply by having one small piece of carpet tested once a year."

• One of the carpets to pass the green tag testing is associated with disabling the members of the Charles

Fitzgerald family of West Friendship, Maryland,who were exposed to it in their lighting store in 1992. When tested by Anderson Labs, the Fitgeralds' carpet caused gross nervous system abnormalities in mice."

• The Consumer Product Safety Commission receives hundreds of complaints and inquiries each year about the adverse health effects associated with the materials used to make carpet,"said Abrahms.

Yet the government has chosen to sweep this problem under the rug by ignoring the public's health concerns as well as my request to disseminate meaningful information about potential carpet hazards."

•“ Nothing has been proven to date that links carpet and ill health effects," says the

CRI's Kathryn Wise .

Cover up (con’t)

EPA cover-up

• a thousand complaints were reported by EPA workers who were made ill by new carpet in the EPA headquarters building. The CRI were

, at a minimum, well aware of neurological complaints and very serious pulmonary complaints from a number of EPA workers."

Despite its own study, and the removal of 27,000 square yards of carpet from the headquarters building in 1989, EPA published a public information brochure, "Indoor Air Quality and New Carpet: What

You Should Know," which states, "Limited research to date has found no links between adverse health effects and the levels of chemicals emitted by new carpet

." http://www.holisticmed.com/carpet/

When EPA returned to its own labs, "instead of duplicating what Rosalind Anderson did, as they were charged to do at the October '92 carpet hearing, EPA created its own protocol," bottled air in their own lab and bubbled it through water to add humidity, the humidity changed the result. What they found was that humidity reduced the toxicity, so apparently whatever the toxins are, they are soluble in water at low levels." After Anderson Labs changed their protocol to humidify the air in the same manner as EPA had done," we found it removed the toxic effect as well," said Anderson. When they passed air over a toxic carpet sample and bubbled it through water, the air was not toxic to the mice.

• took that water and exposed the mice to it in the form of a mist. "Lo and behold, the toxic effect had been removed from the air and put into the water.

• We were now seeing the same enurotoxic effects from the water, including death, said Anderson.

Recommendation:

• Do not contact the EPA or Consumer Product Safety Commission (CPSC) with the expectation of getting help with the problem. While they may do good work on other issues, they are in bed with the industry on this issue, so do not trust anything they say. http://www.holisticmed.com/carpet/

Cover up (con’t)

Peer –reviewed articles and journals are mistakenly presented to be of high quality.

Product defense firms establish their own journals, using their own scientists, that present themselves to the unwary as independent sources of information and science.

Example: Indoor and Built Environment Journal

Resources:

• To understand how PR techniques are sometimes used to by Monsanto, Dupont and others to con the general public, please purchase and read the excellent new book: Toxic Sludge is Good For You! (Lies,

Damn Lies and the Public Relations Industry by John Stauber and Sheldon Rampton Common Courage

Press, Monroe, Maine (USA), c1995 ISBN 1-56751-061-2 or ISBN 1-56751-060-4 (pbk.) This book will help you understand what tricks to expect from Monsanto, Dupont, and others as scientists and the general population recognizes the dangers from exposure to toxic carpeting.

• Doubt is Their Product David Michaels, 2008 by Oxford Press

Peer –reviewed articles and journals are mistakenly presented to be of high quality.Product defense firms establish their own journals, using their own scientists, that present themselves to the unwary as independent sources of information and science.

Examples: JOURNAL: Indoor and Built Environment , financed by the tobacco industry to promote that inadequate ventilation, not second hand smoke, is the problem.

JOURNAL : Regulations, Toxicology and Pharmacology An association dominated by scientist who work for industry trade groups and consulting firms.

In 1986 Duehring founded the

Environmental Access

Research Network (EARN).

• 1991, the Agency for Toxic

Substances and Disease

Registry designated CIIN a clearinghouse to aid communities and individuals on the toxic health effects associated with low levels of chemical exposure

• In 1994 became Chemical

Injury Information Network

(CIIN).

CIIN is a support and advocacy organization for the benefit of the chemically injured with over

5,000 members in 35 countries.

Its primary focus is education, credible research, multiple chemical sensitivity (MCS), and the empowerment of the chemically injured.

She was awarded

The Right Livelihood

Award

“...

for putting her personal tragedy at the service of humanity by helping others understand

CIIN works with healthcare professionals and governments in many countries, and the United

Nations Environment

Program and the

European Union have both recognized

.

CIIN/EARN's work.

Cindy Duehring

(1962 - 1999)

Researcher, Activist, Writer, Editor

1997 Right Livelihood Award Winner

and combat the risks posed by toxic chemicals.”

Sources

 www.ciin.org The Chemical Center Information Network http://www.inspiredliving.com/airpurification/a~toxic-carpets1.htm

http://www.naturalhomeproducts.com/1430chemicals.html

Natural

Home Design Center

Journal of nutritional medicine ISSN 0955-6664 Source / Source

1995, vol. 5, n o 4, pp. 375-386 (24 ref.

) http://webmail.aol.com/30746-

111/aol-1/en-us/Suite.aspx

CARPET CONCERNS: Carpet Installers Speak Out

As the Medical Evidence Mounts.by Cindy Duehring http://www.inspiredliving.com/airpurification/a~toxic-carpets2.htm

Methyl Isocyanate. Technology Transfer Network., EPA. November 6,

2007. January 32, 2010. http://www.epa.gov/ttn/atw/hlthef/methylis.html

Lecture: Sam Castor, On History of Glycoproteins, a New Biology. Feb

19, 2010. Seattle , WA

Lecture: Dr. Costa, UW , Seattle, WA Feb 17, 2010 http://www.glycoscience.co.za/index.htm

http://www.rightlivelihood.org/uploads/tx_templavoila/Kopbilder_Recipients_01.jpg

http://www.holisticmed.com/carpet/ summary of cover-up,examples of disable carpet layers

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