Research Update
Vivian S. Lee, M.D., Ph.D., M.B.A.
Fall 2010
1
Shared Goal: #25 in NIH Funding by 2015
~$246M
to be
top-20 in
FY20
Need
~$190M to
be top-25 in
FY15
+~$111 m
+~$55 m
Non-ARRA
up 5%/yr
since FY08
(+20%/yr
w/ARRA)
- ARRA to-date
- Non ARRA
See appendix for assumptions. Source: Shulman grant projection model; econometric principles and algorithms that drive the modeling are proprietary and there is a patent pending
Our Goals

Advance scientific discovery and innovation and foster a highly
collaborative model of interdisciplinary scientific investigation

Improve productivity and enable growth

Facilitate research through effective administration

Invest in training and career development

Stay at the cutting edge of enabling technologies and shared
resources
Faculty Recruitment
• Science Strategy Committee
– Review of all TT or tenured
research faculty recruits
– Ensures highest caliber
– Enables better integration of
new recruits into the
community
– Cross-departmental mentoring
• Since 2007,
– 76 recruits reviewed
• 5 denied
• 71 approved
– 45 accepted
– 20 declined
– 6 pending
• Strategic Areas
–
–
–
–
–
–
Cancer Institute
Musculoskeletal Institute
Neuroscience Institute
Cardiovascular Institute
Children’s Health
I3: immunology, inflammation,
infection*
– Public health and population
sciences*
– Other areas of focus
•
•
•
•
•
Diabetes, metabolism, and obesity
Genetics and epigenetics
Stem cells
Drug discovery
Imaging
11% of the T/TT Faculty have been
recruited in past 3 years
Profile of Tenure/Tenure Track Faculty
Basic
Assistant
Associate
Professor
Clinical
Assistant
Associate
Professor
Instructor
Total T/TT Faculty
Here before
FY2008
134
22
41
71
338
87
88
159
4
472
Recruited
Total Recruits FY08
in past 3
T/TT - FY10 as a %
years? Faculty of Total Sector
25
159
16%
19
41
46%
4
45
9%
2
73
3%
32
370
8%
21
108
19%
5
93
3%
6
165
4%
4
0%
57*
529
11%
5
* Excludes 2 T/TT assistant professors recruited between FY08 and FY10 who have left the organization
Most Recruited Faculty Meet or Exceed
Grant Salary Coverage Plan
46 of the T/TT faculty recruited between FY08 and FY10 had expected or actual salary
coverage on grants. Of these, 32 are at or above targeted grant salary coverage levels.
Number of FY08 – FY10 Recruits by Grant
Salary Coverage Variance
For Grant Salary Coverage To-Date
6
Senior Recruits Meet or Exceed Average
NIH Awards for Their Rank
While it is too early to judge the success of T/TT recruits at the Assistant level, those at
the Associate and Professor level are performing well in terms of awards generated
Annual Awards per T/TT Faculty Member by Level
($ 000s)
7
*Note that only 6 of 42 Assistant level recruits have been here 3 full years and only half have been here 2 full years, so comparison to
the entire cadre of assistant professors, many of whom are much further along in their careers, is setting an unrealistically high bar
New NYU Faculty Recruits
(as of 7/1/10)
Name
Dept/Div
Schmidt, Ann Marie, MD
Yan, Si-Fan, MD
Ramasamy, Ravichandran, PhD
Jin, Chunyan, MD, PhD
Placantonakis, Dimitris, MD, PhD
Li, Huilin, PhD
Fitzgerald, Matthew, PhD
Branski, Ryan, PhD
Delmar, Mario, MD, PhD
Cuddapah, Suresh, PhD
Rothenberg, Eli, PhD
Fenyö, David, PhD
Koralov, Sergei, PhD
Lin, Dayu, PhD
Tahiliani, Mamta, PhD
Cadwell, Ken, PhD
Silverman, Gregg MD
Schober, Markus, PhD
Med/Endo
Med/Endo
Med/Endo
EnvMed/Epigenetics
Neurosurgery
EnvMed/Biostats
Otolaryngology
Otolaryngology
Med/Cardio
EnvMed/Epigenetics
Biochemistry
Biochemistry
Pathology
Psych/Neuroscience
Skirball/Biochem
Skirball/Micro
Rheum/MSK CoE
Derm/Cell Bio
Start date
7/1/10
7/1/10
7/1/10
7/1/10
7/15/10
8/1/10
8/1/10
8/1/10
9/1/10
9/1/10
9/1/10
10/15/10
11/1/10
11/1/10
11/1/10
11/1/10
12/1/10
4/1/11
New NYU Faculty Recruits
(as of 7/1/10)
Name
Dept/Div
Schmidt, Ann Marie, MD
Yan, Si-Fan, MD
Ramasamy, Ravichandran, PhD
Jin, Chunyan, MD, PhD
Placantonakis, Dimitris, MD, PhD
Li, Huilin, PhD
Fitzgerald, Matthew, PhD
Branski, Ryan, PhD
Delmar, Mario, MD, PhD
Cuddapah, Suresh, PhD
Rothenberg, Eli, PhD
Fenyö, David, PhD
Koralov, Sergei, PhD
Lin, Dayu, PhD
Tahiliani, Mamta, PhD
Cadwell, Ken, PhD
Silverman, Gregg MD
Schober, Markus, PhD
Med/Endo
Med/Endo
Med/Endo
EnvMed/Epigenetics
Neurosurgery
EnvMed/Biostats
Otolaryngology
Otolaryngology
Med/Cardio
EnvMed/Epigenetics
Biochemistry
Biochemistry
Pathology
Psych/Neuroscience
Skirball/Biochem
Skirball/Micro
Rheum/MSK CoE
Derm/Cell Bio
Start date
7/1/10
7/1/10
7/1/10
7/1/10
7/15/10
8/1/10
8/1/10
8/1/10
9/1/10
9/1/10
9/1/10
10/15/10
11/1/10
11/1/10
11/1/10
11/1/10
12/1/10
4/1/11
Ann Marie Schmidt, M.D.
Iven Young Professor of Endocrinology
Director, Diabetes Research Program
• Identified and characterizing RAGE molecule
and its role in the development of
complications of diabetes, leading to their first
antagonist drug in early phase II clinical trials
• Previously, Columbia Department of Surgery
• NYU alumna, Solomon Benson Alumni
Achievement Award recipient
• PI
– PPG (NIA): Aging & Vulnerability to Ischemia
– PPG (NHLBI): RAGE and mechanisms of vascular
dysfunction
– Project & Core leader on a 3rd PPG (RAGE, nerve
injury, regeneration & aging)
– JDRF Scholar, several JDRF grants
– New 3 yr $2.4m PPG from JDRF: RAGE signal
transduction: Novel treatments for T1 diabetes
complications
Ravichandran Ramasamy, Ph.D
Associate Professor of Medicine
Diabetes Research Program
• Investigating aldose reductase pathway as
target for therapy to prevent complications of
diabetes
• Previously, Columbia Department of Surgery
• PhD Loyola University of Chicago, Postdoc UT
Dallas and UC Davis
• PI
– Project Leader, PPG (AMS): Polyol pathway &
mechanisms of ischemic injury in aging, Animal
experimentation Core.
– R01 (NHLBI): RAGE, diabetes, and myocardial
infarction
– Several JDRF grants
Shi-Fang Yan, M.D.
Associate Professor of Medicine
Diabetes Research Program
• Investigating biochemical and signaling
mechanisms by which PKCbeta and EGR-1
contribute to lesion development and
progression in atherosclerosis
• Previously, Columbia Department of Surgery
• MD, Fujian Medical School, China, Postdoc
Molecular Biology Beijing Union Medical
University and Columbia University
• PI
– Project and Core Leader, PPG (AMS): AR & AGERAGE in Aging: impact on endothelial and vascular
stress; Transgenic core
– R01 (NHLBI): EGR-1, PKC beta, signaling and
atherosclerosis
– Several JDRF grants
Chunyuan Jin, M.D., Ph.D.
Assistant Professor of Environmental Medicine
• Research goals: mechanisms of transcriptional
regulation by unstable H3.3/H2A.Z NCPs and the
role of these in T-acute lymphoblastic leukemia
• Previously, postdoc NIDDK: Characterizing
properties and genome-wide profiling of
nucleosomes containing different histone variants
(Felsenfeld)
• PhD, Gene Engineering Division, BioResource Center
& Tokyo University: Epigenetic regulation of
differentiation of the mbryonic carcinoma cells
• Pubs
– Jin C… Felsenfeld G. H3.3/H2A.Z double variant-containing
nucleosomes mark ‘nucleosome-free regions” of active
promoters and other regulatory regions. Nat Genet 2009;
41:941
– Jin C & Felsenfeld G. Nucleosome stability mediated by histone
variants H3.3 and H2A.Z. Genes & Dev 2007; 21:1519
– Jin C & Felsenfeld G. Distribution of histone variant H3.3 in
erythroid cell lineage. PNAS 2006; 103:574.
– Jin C…Yokoyama KK. Transcrition factor JDP2 is involved in
histone modification and nucleosome assembly. Nat Struct Mol
Biol 2006 (Cover)
Suresh Cuddapah, Ph.D.
Assistant Professor of Environmental Medicine
• Research goals: identify causes for aberration in the
chromatin domain structure that leads to
tumorigenesis—role of insulator binding protein CTCF;
molecular and epigenetic basis of mixed lineage
leukemia.
• Previously, Staff scientist, NHLBI
• PhD, Biotechnology, Central Food Technological
Research Institute, India; MPhil, MSc. Zoology, Loyola
College, Univ of Madras, India
• Pubs
– Barski A, Jothi R, Cuddapah S* (co-1st)…Zhao K. Chromatin poises
protein-coding and miRNA genes for expression. Genome Research
2009;19:1742.
– Cuddapah S…Zhao K. Global analysis of the insulator binding
protein CTCF reveals demarcation of active and repressive
chromatin domains. Genome Research 2009; 19:24.
– Cuddapah S…Zhao K. Transcriptional enhancer factor 1 (TEF1/TEAD1) mediates ativation of IFITM3 gene by BRG1. FEBS Letters
2009;582:391.
– Barski A, Cuddapah S* (co-1st)…Zhao K. High-resolution profiling of
histone methylations in the human genome. Cell 2007;129:823.
– Roh T-Y, Cuddapah S* (co-1st)…Zhao K. The genomic landscape of
histone modifications in human T cells. PNAS 2006; 103:15782.
Huilin Li, Ph.D.
Assistant Professor of Environmental Medicine, Division of Biostatistics
• Research goals:
– Impact of error in covariate prevalence estimates and
use of hierarchical models to improve prevalence
estimates
– GWAS: analyze associations between genetic variants
and secondary phenotypes (CA-125)
– Trend test for association for complex diseases
• Previously, Research fellow, Biometrics Branch, Div
Cancer Epidemiology (M. Gail, NCI)
• PhD, Univ of Maryland (Lahiri): Small area estimation:
an empirical best linear unbiased prediction approach
• Awards: DCEG Fellows Award for research excellence
• Pubs (5)
– Li H, et al. Using cases from genome-wide association studies to
strengthen inference on the association between single nucleotide
polymorphisms and a secondary phenotype. Genetic Epidemiology,
in press
– Li H, et al. Covariate adjustment and ranking methods to identify
regions with high and low mortality rates. Biometrics, in press.
– Li H and Lahiri P. Adjusted maximum likelihood method in the small
area estimation problem. J of Multivarate Analysis. 2010; 101:882
Mario Delmar, M.D.
Professor of Medicine, Cardiology Division
•
•
•
Leading expert in cellular electrophysiology and
arrhythmia mechanisms, focusing on cell junctions,
establishing “ball and chain” gating model for gap
junction channels, developing peptides for antiarrhythmic therapies
Previously, University of Michigan, Center for
Arrhythmia Research
Originally trained in Mexico
– Postdoctoral fellow, SUNY Upstate (Jose Jalife)
– SUNY Upstate: Prof and Vice-Chair
•
•
Fellow AHA, Heart Rhythm Society
PI
– R01 (NIGMS): pH regulation of connexin43
– RC1 (NHLBI): Stem cells and the fibroblast/adipocyte lineage
in arrhythmogenic cardiomyopathy
– Project leader P01 (Jalife) Role of Cx43 regulation in cardiac
function
– Project leader P01 (Jalife) Arrhythmia mechanisms in two
inherited cardiac diseases
– Leduc Transatlantic Network, Core member
Matthew Fitzgerald, Ph.D.
Assistant Professor of Otolaryngology
•
•
•
•
Research goals: development of real-time processing
to optimize fitting of bilateral cochlear implants,
reduce time to adapt to electrical stimulation
Previously, Postdoc, NYU Otolaryngology (Svirsky)
Ph.D. Northwestern Univ, Communication sciences
and disorders
PI
– K99/R00 (NIDCD): Optimizing fitting of bilateral
cochlear implants
•
Pubs (9)
– Fitzgerald MB…Svirsky MA. Reimplantation of hybrid
cochlear implant users with a full length electrode after
loss of residual hearing. Otol Neurotol 2008; 29:168.
– Fitzgerald MB…Svirsky MA. The effect of perimodiolar
placement on speech perception and frequency
discrimination by cochlear implant users. Acta
Otolaryngologica 2007;127:374.
– Fitzgerald MB & Wright BA. A perceptual learning
investigation into the pitch elicited by amplitudemodulated noise. J Acoustical Soc of Am. 2005;118:3794
Ryan Branski, Ph.D.
Assistant Professor of Otolaryngology, NYU Voice Center
•
•
•
•
•
Research goals (50%): Investigating the role of COX-2 in
vocal fold wound healing, effects of KTP laser on scarred
vocal folds
Previously, Assistant attending scientist, MSKCC
PhD Health and Rehabilitation Sciences, U. Pittsburgh
Clinical Fellow, Speech/Voice Pathology, U. Pittsburgh
PI
– R03 (NIDCD): Inflammation and fibrosis of the vocal folds
•
Pubs (20)
– Branski RC…Kraus DH. Cigarette smoke and reactive
oxygen species metabolism: Implications for the
pathophysiology of Reinke’s Edema. Laryngoscope
2009;119:2014.
– Branski RC…Felsen D. The effects of transforming growth
factor (TGF)-b1 on human vocal fold fibroblasts. Annals of
Otology, Rhinology, and Laryngology. 2009; 118:218.
– Branski RC…Agrawal S. Dynamic biomechanical strain
inhibites IL-1b-induced inflammation in vocal fold
fibroblasts. J of Voice. 2007;21:651.
Dimitris Placantonakis, M.D., Ph.D.
Assistant Professor of Neurosurgery
•
•
•
•
•
Research goals: genetic analysis of developmentally
regulated miRNAs expressed in human embryonic stem
cell-derived motor neurons; developmental profiling of
human glioblastomas using bacterial artifical chromosomes
Previously, Resident/Fellow Neurosurgery Cornell
Postdoc, MSK, Enriched motor neuron populations derived
from BAC-transgenic human embyronic stem cells (Studer,
Tabar)
MD/PhD (MSTP, AOA) NYU; PhD (Welsh): On the role of
gap junctional communication in inferior olivary oscillations
Pubs (19)
– Placantonakis DG…Schwartz TH. Bilateral intracranial electrodes
for lateralizing intractable epilepsy. Neurosurgery 2010;66:274
– Placantonakis DG…Studer L. BAC transgenesis in human ES cells as
a novel tool to define the human neural lineage. Stem Cells.
2009;27:521.
– Placantonakis DG … Welsh JP. Continuous electrical oscillations
emerge from a coupled network: A study of the inferior olive
using lentiviral knockdown of connexin36. J Neuroscience
2006;26:5008
– Placantonakis DG … Welsh JP. Fundamental role of inferior olive
connexin 36 in muscle coherence during tremor. PNAS 2004;
101:7164
Eli Rothenberg, Ph.D.
Assistant Professor of Biochemistry
•
Research goals:
– Advanced biophotonics and superresolution microscopy:
modified QDs for 3D microscopy in live cells
– Single molecule microscopy: tracking viral infection pathways
and cellular delivery of genetic materials
– Novel nanoprobes and nanotechnology-based assays:
colloidal metallic and semiconductor nanoparticles, metallic
nanoparticles, lipid vesicles
•
•
•
Postdoc, Univ of Illinois, Urbana (Taekjip Ha), Advanced
optical methods and biophotonics, single molecule
microscopy
PhD, Hebrew University (Uri Banin): Optical and electronic
propertites of ensemble and single nanocrystals
semiconductor quantum rods
Pubs (15)
– Rothenberg E & Ha T. Single molecule FRET analysis of helicase
functions. Methods in Molecular Biology 2009; 587:18
– Rothenberg E…Ha T. Human Rad52-mediated homology search
and annealing occurs by continuous interactions between
overlapping nucleoprotein complexes. PNAS 2008;205;20274
– Rothenberg E…Ha T. MCM fork substrate specificity involves
dynamic interaction with the 5’ tail. JBC 2007;282:34229 (cover)
David Fenyö, Ph.D.
Associate Professor of Biochemistry, CHIBI
Head, Computational Proteomics Laboratory
•
Research goals:
– Proteomic data analysis, methods and databases for protein
identification, characterization and quantification using mass
spectrometry-based technologies
•
•
•
Previously, Senior Research Associate, Rockefeller
University; ProteoMetrics (start-up), President, Director of
Proteomics at Genomic Solutions; Staff Scientist at GE
PhD, Uppsala University (Sweden)
Pubs (>80)
– Sekedat MD, Fenyö D, Tackett AJ, Aitchison JD, Chait BT. Direct
Genome-Wide View of DNA Replication Fork Progression in S.
cerevisiae, From the Perspective of the GINS Complex. Molecular
Systems Biology. 6 (2010) 353.
– Eriksson J & Fenyö D. Predicting the Success Rate of Proteome
Analysis by Modeling Protein Abundance Distributions and
Experimental Designs. Nature Biotech, 25 (2007) 651-655.
– Fenyö D & Beavis RC. A method for assessing the statistical
significance of mass spectrometry-based protein identifications using
general scoring schemes. Anal Chem. 75 (2003) 768-74.
– Eriksson J, Chait BT, & Fenyö D. A Statistical Basis for Testing the
Significance of Mass Spectrometric Protein Identification Results.
Analytical Chemistry 72 (2000) 999-1005.
Collaborations and Teams
450
400
350
300
250
200
150
100
50
0
Total Count of NIH Grants
All Other
129
All Other
195
R01
193
R01
217
NYULMC
Mount
Sinai
All Other
192
R01
194
$200.0
$180.0
$160.0
$140.0
$120.0
$100.0
$80.0
$60.0
$40.0
$20.0
$-
All Other
153
R01
204
Univ of Univ of
Alabama Virginia
Total $ NIH Funding
All Other
$100.6
All Other
$50.0
R01
$76.4
All Other All Other
$92.3
$70.7
R01
$83.4
R01
$64.0
R01
$68.7
NYULMC Mount Univ of Univ of
Sinai Alabama Virginia
A comparison between NYULMC and the Milestone Competitors, focusing on the 2009 awards
for non-R01 grants, identifies potential opportunities in the U series and P series grant areas.
$100.0
Other, $7.1
T Series, $5.3
K, L Series, $6.8
$80.0
Other, $2.7
T Series, $4.3
K, L Series, $6.4
P Series, $28.5
$60.0
$40.0
U Series, $40.4
P Series, $16.4
$20.0
$-
P Series, $30.7
Other, $19.7
U Series, $33.3
T Series, $6.5
K, L Series, $4.1
P Series, $14.5
Other, $2.4
T Series, $4.4
K, L Series, $4.3
U Series, $17.4
U Series, $12.4
R Series (less R01), $10.2
R Series (less R01), $12.6
NYULMC
Mount Sinai
U Series
R Series (less R01)
Note: Fund amounts in $MM
Other: D Series, M01, S Series, F Series, G Series
P Series
R Series (less R01), $14.9
Univ of Alabama
K, L Series
T Series
R Series (less R01), $8.4
Univ of Virginia
Other
Strategic Initiatives: Interdisciplinary Research
• Centers of Excellence
– Many active programs and initiatives
• Seminars, seed grant programs, new collaborations
• Addiction, Brain Aging and Urological Disease retreats
– CoE renewals/RFA Fall 2011
• New Institutes
– Neuroscience Institute
– I3 (Inflammation, Infection, Immunology)
– Public Health
• Sources of Internal support:
– PPG Development team (Henry Sun, Claudio Basilico, co-Chairs)
• Continues to review proposals for up to $100,000 in funding
• More active role in reviewing proposals (SPORE), earlier stages
• Workshop planned for early 2011
– NYU-Geisinger collaboration: Seed grants in health services research
– NYU-Polytechnic Institute
Neuroscience Institute Update
• Neuroscience Institute Director: Richard Tsien
– R. Lehmann, chair
• Neuroscience training grant funded
– Co-PI: Stewart Bloomfield and Eric Klann
• Neuroscience Advisory Committee
recommendations
–
–
–
–
E. Ziff, chair
Neuroscience Prize
Recruiting graduate and MD/PhD students
Ideas for enhancing career development/support for
junior faculty
– Core facilities
– And more
• Neuroscience website
http://neuroscience.med.nyu.edu/
I3: Inflammation, Infection, Immunology
• Bringing together the expertise
–
–
–
–
–
–
–
–
Microbiology
Pathology
Infectious Disease
Medicine/Microbiome
Rheumatology
Parasitology
Skirball Molecular Pathogenesis
And most clinical departments
• CoE proposals
–
–
–
–
–
–
Inflammation
Microbiome
Global Health
Asthma
Multiple Sclerosis
Musculoskeletal Disease
(Rheumatology)
– And others
• Develop the training program, coordinate seminar series, website,
strengthen the community
• First I3 Retreat: May 12, 2010, Second retreat in planning for June 2011
• Linda Miller, Assoc Dean for Basic Science, coordinating efforts
Public Health
• Verizon building acquisition
– 30th St between 2nd and 3rd avenues
– 3½ floors programmed for CTSI and public health research, including lecture room
• Home to
–
–
–
–
–
CTSI
Health Informatics and Bioinformatics (CHIBI)
New Department of Biostatistics and Epidemiology
Community health
Population Science—comparative effectiveness, decision analysis, health
economics, and more
– Coordinated with the Cancer Institute Population Science initiative
– New initiative: Innovations in health care delivery
•
Exploring new recruits jointly with Stern/Wagner in health management and policy
Opportunity for Increased Clinical
Research is Also Substantial
NIH Awards Distribution at NYU
& MSSM – Basic Science v.
Clinical Departments ($millions)
NIH Cardiovascular Funding:
Comparison of NYU and
MSSM ($ millions)
Note: Classification of grants as “cardiovascular” is based on
NIH Research, Condition, and Disease Category (RCDC)
designations; classification of grants as “clinical” is based on
NYULMC review.
27
CTSI News…
o The CTSI Translational Research/Novel Technologies Program awarded 20 Pilot Projects
(T1-T3) totaling $770k. A new RFA for CTSI Pilot Projects was issued 9/1/10.
o The CTSI Translational Research Education and Careers (TREC) Core awarded:
-6 TL1 trainees and 4 KL2 scholars (one CTSI KL2 scholar recently received a K23 grant).
o The Translational Research-in-Progress (TRIP) seminar (sponsored by the Department of
Medicine and the CTSI) provides a forum for presentation of work-in-progress by
Basic/Clinical and Translational scientists
o The Community Engagement and Population Health Research (CEPHR) Core and the
Value and Comparative Effectiveness Core (DGIM) are partnering on a number of grants
in health services research
o The CTSI Governance, Study Design & Biostatistics, and Bioinformatics Cores developed
the CTSI Protocol Studios to offer investigators an opportunity to have protocols and
manuscripts reviewed and critiqued by an expert faculty panel.
o The Best Practices Integrative Informatics Consultation Service (BPIC) of the CTSI
Bioinformatics Core has performed ~100 formal consultations since October 2009, and is
instrumental in developing the federated data warehouse proposal, and in implementing
the Find-A-Researcher 2.0 prototype: Open Office Hours every week
o The CTSI Clinical Research Center (former GCRC) maintains >90 active studies and
anticipates two dozen new inpatient and 20 outpatient studies this year
Our Goals

Advance scientific discovery and innovation and foster a highly
collaborative model of interdisciplinary scientific investigation

Improve productivity and enable growth

Facilitate research through effective administration

Invest in training and career development

Stay at the cutting edge of enabling technologies and shared
resources
Understanding the pressures:
Productivity and Growth
• Academic medical centers are businesses with unique missions
• The aim of research administration is to provide a rich environment for the
conduct of great research and to shield PIs as much as possible from the
business side of the business
• The reputation of an academic medical center depends heavily on research:
–
–
–
–
Major programs and institutes with critical mass
Recruit outstanding faculty
Improved and expanded space
Core facilities and technologies
• To persuade the Board to invest in research, we must make excellent use of
our resources
– Improve productivity of some faculty
– Improve effectiveness of our support services, reduce duplication (IT, finance etc)
– Use space more efficiently
• We need to validate the investments in research to our Board through the
quality of the science, impact of discovery and innovation, and through
improved grant and technology transfer revenue
Faculty Productivity
• AEC salary coverage minimum for 2010-11 = 60%
• New incentive/rewards for well-funded investigators
– Emphasis on salary coverage significantly exceeding AEC targets
– Emphasis on multiple NIH grants
– Emphasis on NIH PPG/Center grants
Overall, our NIH activity is highly reliant on a
small number of highly productive faculty…
Profile of Top-50 Faculty in terms of NIH
Successes FY08 – FY10
Basic
Sum of Total NIH Sum of Total NIH
Proposals
Successes
Faculty
($ millions)
($ millions)
25
$ 392.2
$ 119.8
Assistant
Associate
Professor
Clinical
Assistant
2
6
17
25
4
$
$
$
$
$
61.5
79.3
251.4
408.3
50.3
$
$
$
$
$
8.3
32.6
78.9
177.0
18.3
Associate
Professor
Grand Total
2
19
50
$
$
$
16.4
341.7
800.5
$
$
$
9.5
149.2
296.8
388
$ 2,611.6
$
475.7
Total Faculty
with 1 or more
NIH proposals
FY08 - FY10:
Of NIH
Successes
(lifetime
value of
awarded
grants)
Of NIH
Proposal
Value
Of Active
NIH
Submitters
32
Note: Includes 13 faculty members who are holders of active “mega grants” valued at >$5 million each
Better performers convert a higher ratio of
proposals to successes
3 year NIH Success: Proposal Conversion
Ratio
29%
Average Value of NIH Successes per
Faculty Member, FY08 - FY10
34%
$4.1
20%
$2.7
$1.4
7%
0%
$0.0
Submitted Bottom
to NIH w/o quartile
Success
(35)
(84)
3rd
quartile
2nd
quartile
Top
quartile
(35)
(34)
(36)
Among 140 Baseline T/TT faculty with NIH Successes
(excludes those with active “mega-grants” & recent recruits)
$0.4
Submitted Bottom
to NIH w/o quartile
Success
(35)
(84)
3rd
quartile
(35)
2nd
quartile
(34)
Top
quartile
(36)
Among 140 Baseline T/TT faculty with NIH Successes
(excludes those with active “mega-grants” & recent recruits)
33
Yet even our most productive faculty
are not at full capacity
~ $20 - $30
million
additional
“capacity” in
our already
successful
faculty
(or 2 R01s with
$375K each)
34
Our Facilities also appear to be
below full capacity
~ $30 million
additional
“capacity” in
our current
research
space
35
Space: Relocations
Increasing space efficiency
• Relocating approx 70,000 SF research space in Rusk, Tisch,
Perelman (total 185,000 SF)
• To manage relocations and growth:
– Most laboratories that have no funding have been asked to close
– Each major administrative/space unit should be expected to “contribute” space
for relocations (faculty, cores, etc)
• Relocating their Rusk/Perelman/Tisch faculty into their existing space
• House core facilities
• Other relocations as needed
– With relocation “duty” fulfilled, departments are recruiting
– Think about “dry space” recruits
New Space
New research space, partly for relocation, mostly for growth
• Verizon (available 2010-2011): Dry space
• ERSP (available 2012): Wet bench
• Varick Street (available 2011): Wet and Dry space
• New building…
New Building!
• New research building: 300,000 SF
– Architect selected
– Occupancy by end 2014
– Neuroscience and i3
Space Policy and Management
• Space Policy drafted, to be rolled out in coming months
• Space survey currently underway
– NIH indirect rate negotiation
– New space management software
• New Space Management Advisory Committee
Understanding the pressures:
Productivity and Growth
• Academic medical centers are businesses with unique missions
• The aim of research administration is to provide a rich environment for the
conduct of great research and to shield PIs as much as possible from the
business side of the business
• The reputation of an academic medical center depends heavily on research:
–
–
–
–
Major programs and institutes with critical mass
Recruit outstanding faculty
Improved and expanded space
Core facilities and technologies
• To persuade the Board to invest in research, we must make excellent use of
our resources
– Improve productivity of some faculty
– Improve effectiveness of our support services, reduce duplication (IT, finance etc)
– Use space more efficiently
• We need to validate the investments in research to our Board through the
quality of the science, impact of discovery and innovation, and through
improved grant and technology transfer revenue
Research Administration
Linda J. Miller, Ph.D.
Associate Dean for Basic Science
• Develop, lead, and coordinate the basic science and
translational components of major collaborative research
initiatives
• Previously, US executive editor for Nature and the Nature
journals
• Founding editor of Nature Immunology
• Editor at Science for 12 years
• Ph.D. Harvard University, Immunology (T. Springer)
• Post-doc, NCI (J. Ihle)
Laura Ahlborn
Vice President for Science Strategy
• Integrating planning around research recruiting, space, and other
resources as necessary to achieve strategic goals, clarify space
management principles and coordinate research moves for campus
transformation
• Previously, University of Pennsylvania School of Medicine and
Health System, Senior Executive Director of Research Planning and
Management where she led research strategic planning process and
represented needs of faculty in planning a new 400,000 SF
translational research building
• 20 years as consultant for academic medical centers and health
systems
• BA Psychology, Wesleyan
Anny Fernandez
Administrator, Office of Science & Research
• Oversee administrative affairs for OSR including budget
oversight, liaison with external collaborators, point of contact
for departmental administrators, Centers of Excellence, and
affiliates.
• Previously, Mt Sinai Medical Center, Department of
Cardiothoracic Surgery
• Departmental Administrator for Parasitology Department, NYU
• Administrative roles at Columbia University , NYC Department
of Education Budget Office, United Nations
• M.S. Social Administration, Columbia
Our Goals

Advance scientific discovery and innovation and foster a highly
collaborative model of interdisciplinary scientific investigation

Invest in training and career development

Facilitate research through effective administration

Stay at the cutting edge of enabling technologies and shared
resources

Improve productivity and enable growth
Technology Transfer
•
•
•
•
FY10 increases in activities (127
inventions received, 56 US patents
issued, 40 licenses, 6 start-ups)
Applied Research Support Fund (ARSF)
reinstituted 2 years ago and expanded.
53 submissions and 8 awards in FY10
of up to $75K each. Historically, $25M
in license and research revenues from
$1.6M in ARSF funding (15:1).
Venture capital fund created in 2010
Frank.rimalovski@nyumc.org
Contact Office of Industrial Liaison to
discuss new ideas, and collaborations
with industry. Under patent law,
important to file patent application
before publishing or presenting.
SPA
• Interim Director: Tony Carna
• Grants budgeting initiative
– Myth: modular grants have a better chance of getting
funded than nonmodular budgets
– Reality: well-justified budgets reflect well thought out
experiments and a seasoned investigator
– Carna’s workshop on budgeting tips (online):
• Budget enough salary support for PI (25-35%)
• Include statisticians, informaticians at sufficient support
• Budget animals, cores, contingencies appropriately
– Budget justification template text under development
Our Goals

Advance scientific discovery and innovation and foster a highly
collaborative model of interdisciplinary scientific investigation

Improve productivity and enable growth

Facilitate research through effective administration

Invest in training and career development

Stay at the cutting edge of enabling technologies and shared
resources
Faculty Development
• Leadership development and management skills course
for faculty
• Grantsmanship course and online resources
• Physician Scientist Training Program
LEADS
Leadership, Education and Development
for Scientists Program
November 1 – 3, 2010
Ken Broadhurst
Svetlana Yedreshteyn
Deirdre Wincewski
Dr. Vivian Lee
50
LEADS Objectives
 Hire, develop and lead an exceptional lab team
 Practice essential management skills:
o
o
o
o
o




hiring and firing,
managing conflict,
managing grants,
teaching and presenting effectively
taking charge of their own career path
Build successful relationships and collaborations
Develop an effective mentoring process for staff
Develop personal leadership skills and self awareness (MBTI)
Receive feedback on their own leadership style (360)
51
Grantsmanship Course

Current offering: Fall 2010
(Jan/Feb submission)






100 attendees
50 “students"
Faculty downtown invited
(Steinhardt, FAS, Wagner)
New pilot: Mock study
sections
Surveying current study
section members for
feedback and insights
Faculty mentors 2010
• Stuart Katz
• Leslie Gold
• Terry Pearl
• Mary Helen Barcellos-Hoff
• Jean-Marie Bruzzese
• Judy Goldberg
• Gabrielle Grunig
• Bruce Cronstein
• Vivian Lee
Strongly encourage ALL faculty planning on submitting grants to
participate—the buddy system and extra “mentors” help encourage
the process
52
Grantsmanship
• Grants library and template
resources
– www.med.nyu.edu/osr click on
grants library
– Sample K and R grants
– Template text for resources page
– Under development: template
text for budget justification and
an excel budget worksheet
Grantsmanship
Animal Resources
Physician Scientist Training Program
•
•
•
•
Eligible: medical residents or fellows in training
Nomination deadline 12/10
18 mo minimum time dedicated to research
Mentor must be federally funded, but can be from any
department
• 2010 Awardees (2010 or 2011 start dates)
Trainee
Department
Amengual
Medicine/Heme-Onc
Gonzalez
Dermatology
Henning
Surgery
Huynh
Medicine/Heme-Onc
Scher
Rheumatology
Segal
Medicine/Pulmonary
Sjulson
Psychiatry
TBA
Dermatology
Our Goals

Advance scientific discovery and innovation and foster a highly
collaborative model of interdisciplinary scientific investigation

Invest in training and career development

Improve productivity and enable growth

Facilitate research through effective administration

Stay at the cutting edge of enabling technologies and shared
resources
Core Facilities and Technologies
• David Levy, Associate Dean for Collaborative Science
• Sheenah Mische, Ph.D., new Senior Director of Core
Services
– M.S. Biochemistry, NYU
– Ph.D. Experimental Pathology, Yale
– Director, Protein/DNA Technology Center, Rockefeller
1990-98
– Director, Starr Center for Human Genetics Genotyping
Core Lab, Rockefeller 1996-98
– Assoc Dir, Dept Immunology and Inflammation
Boehringer Ingelheim, 1998-2005
– Assoc Dir, Dept Protein Resources, BI 2005-06
– Director, Dept Translational Sciences, BI 2007-08
– Assoc Dir, Talent Acquisition—Academic Relations, BI
2008-10
Office of Collaborative Science
RNAi Genome-wide Screening
Enhancing Research Collaboration Through Technology
Genomics Technology Center
Small animal imaging –
CfAR
Radiology/Cardiology
CI
Flow Cytometry
Skirball
Microscopy
OCS Neuroscience rodent
TABS
(Tissue Acquisition & Biorepository)
COEs
Histopathology / IHC / IF
Transgenics / GEM
Smilow Central Services
behavior lab
CTSI
Proteomics
http://www.nyuinformatics.org/services/bpic#clinics
Our Goals

Advance scientific discovery and innovation and foster a highly
collaborative model of interdisciplinary scientific investigation

Improve productivity and enable growth

Facilitate research through effective administration

Invest in training and career development

Stay at the cutting edge of enabling technologies and shared
resources
Thank you for all that you do.
Questions?
vivian.lee@med.nyu.edu
212-263-2095
Animal resources
• Space
– The Berg G20 barrier will help decompress Skirball and Smilow, as “dual
users” move to the new barrier
– Smilow will be getting additional caging, which will increase capacity by
~1,000 cages
• Construction
– Real Estate is working with DLAR and an acoustics firm to determine any
potential effect of noise/vibration on vivaria due to campus projects
• Preliminary testing indicates vibration and noise levels are well below the
threshold for concern
• Health Status of rodent colonies
– Skirball and Smilow have historically had mouse norovirus and
Helicobacter in majority of animals (rederivation required for eradication)
• These are ubiquitous organisms that do not affect the most research studies
• Norovirus-free and Helicobacter-free space is available for those who need it
Clinical Research: Some Questions
• How do we balance the need to build clinical revenue with the desire to do
clinical research?
– How do we build a critical mass of clinical researchers?
– Subject recruitment
– Survival and success of junior physician scientists
• What is the best model for a successful clinical research enterprise? MSI?
Can we recreate for other areas?
• How will research impact inpatient care in the future?
• What is the clinical research of the future?
– -omics/personalized medicine
– Outcomes/effectiveness/health care delivery
64
Clinical Research: Some Sources of Answers
• CTSI: Many new initiatives
• Clinical Research Advisory Board (Hochman/Keefe)
• Clinical Trials Advisory Committee (Aberg)
• Departmental chairs and Institute directors and other leaders
• LEAN Initiative:
– Value Stream Analysis (10/10-10/14/10): Streamlining Clinical Protocol Approval
– Rapid Improvement Events planned: Industry Contracting Process, Faculty
Recruitment, Coordinating Approvals, Reducing IRB Deferrals
LEADS Curriculum
Day 2:
Day 1:
 Personal Strengths and Style (Myers
Briggs Type Indicator)
 Enhancing Teamwork and Productivity
 Lunch Discussion – Managing Your
Time, Maintaining Work/Life Balance
 Leadership Skills -- Listening,
Delegating, Coaching
 360 Assessment Feedback and
Development Planning
 Staffing Your Lab or Research Program
 Running Your Lab or Scientific Program
 Tenure and Promotion Processes
 Lunch Discussion -- Speed Mentoring
 Conflict Management & Having Difficult
Conversations
Day 3:
 Managing Performance
 Financing Your Research and Managing Your
Funds

Lunch Discussion: Building a Life in Science


Career Planning: Promotion and Governance
Preparing Effective Scientific Presentations &
Publishing Your Research
Building Collaborative Relationships

There is a high degree of variability in research activity
among “baseline” T/TT faculty
We have further distinguished “baseline” faculty, those recruited prior to FY08, from
those recruited between FY08 and FY10. The data below are for the 472 “baseline”
T/TT faculty
50% of T/TT Faculty
submitted at least 1
NIH proposal FY08 –
FY10
Basic
Assistant
Associate
Professor
Clinical
Assistant
Associate
Professor
Instructor
Total
% Total
Baseline T/TT faculty with total average research
expenditures/yr of:
$100,000- $25,000 to
$250,000+ 249,999
99,999 <$25,000 Total
97
14
2
21
134
17
3
2
22
28
3
2
8
41
52
8
11
71
90
32
33
183
338
17
15
12
43
87
13
13
6
56
88
60
4
14
81
159
1
3
4
187
46
35
204
472
40%
10%
8%
43%
100%
Bi-modal distribution of baseline
T/TT faculty research
67
expenditures
Note: Includes 13 faculty members who are holders of active “mega grants” valued at >$5 million each
There is a strong correlation between level of
NIH funding and both the number and size of
proposals submitted
(35)
(35)
(34)
(36)
(84)
(35)
(35)
(34)
(36)
(84)
Among 140 Baseline T/TT faculty with NIH Successes
Among 140 Baseline T/TT faculty with NIH Successes
(excludes those with active “mega-grants” & recent recruits)
(excludes those with active “mega-grants” & recent recruits)
69