BOOK QUIZ # 3
Chapter 7
1. The original experiment on intracranial self-stimulation (ICSS) that established its
rewarding nature
1. Was done by Olds in 1954
2. Was done by Marlatt in 1980
3. Was done by Hebb in 1948
4. Was done by Pavlov in 1909
2. Heilig says that the fact that ICSS rats are willing to cross a grid where they get a
shock in order to self-stimulate for pleasure
1. Is an indication of brain damage
2. Is not relevant to SUDs
3. Is a diagnostic criterion of addiction
4. Is hard to interpret because we don’t know why they do it
3. Arvid Carlson received a Nobel Prize for
1. ICSS studies
2. Establishing that alcoholism is a disease
3. Showing that heredity contributes to addiction
4. Establishing dopamine (the neurotransmitter associated with reward) as a
neurohumoral mediator
4. Animals will stop self-stimulating when tiny amounts of dopamine blockers (such as
antipsychotics) are injected into
1. The forebrain
2. The prefrontal areas of the cortex
3. The nucleus accumbens
4. The amygdala
5. Conditioned place preference is most robustly obtained with
1. Stimulants and opioids
2. Alcohol
3. Nicotine
4. Cannabis
6. Dopamine neurons are activated by events that are
1. Worse than predicted
2. Better than predicted
3. As good as predicted
4. There is actually no relationship
7. In severe treatment seeking alcoholics
1. There is a higher than normal level of dopamine release in the nucleus accumbens
2. The dopamine level is not mirrored by the reported high
3. The dopamine level is the same as for other addictive substances
4. There is simply nothing left of the dopamine response and the patient reports
that the high has really declined
8. The Incentive Sensitization Theory says
1. That liking is more important than wanting
2. That the mesolimbic dopamine reward system is ultimately not the best way of
understanding addiction
3. That drug seeking can be understood by the paradoxical observation that
“rewarding” properties of addictive drugs decline as people develop more
severe addictive disorders
4. That the incentive for an addicting drug is always the pleasure of using it and that
increases with use
9. Liking is more associated with
1. Endorphins
2. Dopamine
3. Serotonin
4. Epinephrine
10. Moneys and people with low numbers of dopamine receptors are more likely
1. To stay clean and sober
2. To develop good social relationships
3. To find stimulants quite pleasurable
4. To become addicted to substances that are not normally associated with a high