Does Temperature Affect The Dissolution Rate of Aspirin?
Alexis Montgomery Tomekia Phillips Shakkirah Simmons and C. Dinitra
2
White
Department of Chemistry1 and Department of Biology2
North Carolina Agricultural and Technical State University, Greensboro, NC 27411
ABSTRACT
Aspirin, also known as acetylsalicylic acid(ASA), is
a salicylate drug, often used as an analgesic to relieve minor aches
and pains, as an antipyretic to reduce fever, and as an antiinflammatory medication. Around the world, the normal usage is to
take this medication by mouth. Drink a full glass of water (8
ounces/240 milliliters) with it unless your doctor tells you otherwise.
Do not lie down for at least 10 minutes after you have taken this
drug. If stomach upset occurs while you are taking this medication,
you may take it with food or milk. Therefore, we decided to test
these methods and determine the most effective solvent for the
dissolution of aspirin. Since people consume aspirin with liquids we
used four commonly used solvents to test our research. Another
determining factor considered in the dissolution of aspirin was the
possibility of various temperatures of the Solvents. In Hot, Cold, and
Room temperature environments we hypothesized that sprite will
work the best as far as dissolving the aspirin most effectively
because it is the most acidic solvent; as opposed to using water,
milk, or apple juice. One tablet was placed into each tube, once the
desired temperature was reached, and the stopwatches were
started. Tubes were shaken every 2 minutes for 30 seconds
throughout this process. The time for complete dissolution was
recorded in minutes and seconds and documented. This process
was repeated for all 12 tubes. Once all times were recorded the data
was placed in charts and a "raw time" was calculated for each liquid
to determine which liquid worked the quickest in overall dissolution.
For all methods water was the best solvent to use for the
consumption and dissolution of aspirin.
METHODS
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We started by labeling the 12 tubes by the name of the liquid they
would contain and also by the temperature in which they would be
stored.
When all the tubes were labeled, 30 mL of each liquid was
measured into the corresponding tubes.
The tubes after being labeled were placed into one of the 3
designated temperature settings:Room,Cold, or Hot(temps. range
from 4 to 70 degrees Celsius).
One tablet was placed into each tube, once the desired
temperature was reached, and the stopwatches were started.
Tubes were shaken every 2 minutes for 30 seconds throughout
this process.
The time for complete dissolution was recorded in minutes and
seconds and documented. This process was repeated for all 12
tubes.
Once all times were recorded the data was placed in charts and a
"raw time" was calculated for each liquid to determine which liquid
worked the quickest in overall dissolution
RESULTS
Room Temperature
Liquid
Milk
Sprite
Water
Apple Juice
Dissolution
Time
58 min 15 sec
34 min 15
sec
21 min 43
sec
45 min 12
sec
Hot Temperature
OBJECTIVE
• To determine whether or not various temperature
Liquid
Milk
Sprite
Dissolution
Time
44 min 03
sec
8 min 20 sec 2 min 20 sec 4 min 43 sec
ranges and solvents will have an affect on the time it
takes to dissolve an aspirin tablet.
HYPOTHESIS
Water
Apple Juice
Cold Temperature
Liquid
Milk
Sprite
Water
Apple Juice
Dissolution
Time
2 hr 2 mins
12 secs
1 hr 24 mins
15 secs
53 mins
2 hr 2 mins
12 secs
We hypothesized that Sprite will work best as far as dissololving
the aspirin most effectively because it is the most acidic solvent
AVERAGE DISSOLUTION TIMES BASED ON
TEMPREATURE SETTING
MATERIALS • 12 50 mL pipette tubes
• 12 CounterAct Pain Tablets
• 90 mL VeryFine Apple Juice
• 90 ml Milk
• 90 mL Water
• 90 mL Sprite
• Water Bath
• Cold Room/Walk-In Refrigerator
• Lab Station
• Stopwatches
Average Dissolution Time For Each Temperature Zone
Hot
39 mins 7 secs
Cold
1 hr 35 mins 34 secs
Room
40 min 11 sec
CONCLUSIONS
For all methods water was the best solvent to use for the
consumption and dissolution of aspirin. therefore, leading
to a false hypothesis.
Although medical Professionals recommend an individual
uses milk as a substitute for water, this study shows that
since milk had the longest dissolutioin rate throughout the
different temperatures, it not only will increase the
longetivity of pain, but also has the potential to not
completely disolve at all.
REFERENCES
•Dissolution of aspirin from tablets containing various buffering agents
Source: Javaid, Karamat. Journal Of Pharmaceutical Sciences Volume: 61
Issue: 9 (1972-09-01) p. 1370-1373. ISSN: 0022-3549
•Loftin, Keith A., USGS, Craig D. Adams, University of Missouri--Rolla,
Michael T. Meyer, USGS, and Rao Surampalli, USEPA. "Ects of Ionic
Strength, Temperature, and PH on Degradation of Selected
Antibiotics." Published in J. Environ. Qual. 37.378–386 (2008): 1-9. Print.
ACKNOWLEDGEMENTS
We would like to Thank Dr. White for making our undergraduate
research experience amazing
We would like to Thank Gregory Goins for providing us with the
necessary tools to thoroughly complete our presentation
We would like to thank Ms. Ashley Brown, our sweet lab assistant,
for coaching us through our invigorating and educating lab
experience
We would like to thank our peers for maintaining a creative and
constructive environment necessary to remain competitive and
strive to reach one common goal.
" SUCCESS"