Rationale for Identification of
Carcinogens for the NSF/UL 440
Health-based Emissions Project
Purpose:
To review the selection criteria for
carcinogenic chemicals to be included in the
NSF/UL 440 standard
The comments expressed in this presentation may or may not reflect the views of the CPSC staff as a whole and the Commission
Draft, Deliberate, and Confidential
Step 1 – Identify organizations that have transparent
and robust qualitative classifications of chemical
carcinogens
• Why?
– So that the standard requests analysis of chemicals that are only known as
or have a high probability of being a carcinogen
– CA 1350 “Target VOCs” (Section 4.1.2) “include known or probable human
carcinogens…”
– CA 1350 draws upon a list of known or probable human carcinogens…”
presented in the Safe Drinking Water and Toxic Enforcement Act of 1986
(Proposition 65) for some of its “Target VOCs”
• Tier 1 organizations (highest transparency and credible science)
– EPA
– NTP
– IARC
• Tier 2 organizations (lesser transparency/methodological familiarity)
– OEHHA proposition 65 listings
– NIOSH
Draft, Deliberate, and Confidential
Step 2 – Determine the classifications that have
appropriate levels of evidence
• Tier 1
– EPA (http://www.epa.gov/iris/)
•
•
•
•
•
•
•
•
2005 - Carcinogenic to Humans
2005 - Likely to be Carcinogenic to Humans
1999 - Carcinogenic to Humans
1999 - Likely to be Carcinogenic in Humans
1996 - Known/Likely Human Carcinogen
1986 - Group A - (Human Carcinogen)
1986 - Group B1 - (Probable Human Carcinogen; Limited evidence of carcinogenicity in humans and
sufficient evidence of carcinogenicity in animals)
1986 - Group B2 - (Probable human carcinogen; Sufficient evidence of carcinogenicity in animals)
– NTP (http://ntp.niehs.nih.gov/?objectid=03C9AF75-E1BF-FF40-DBA9EC0928DF8B15)
•
•
Known to be a Human Carcinogen
Reasonably Anticipated to be Human Carcinogen
– IARC (http://monographs.iarc.fr/ENG/Classification/index.php)
•
•
Group 1 – (Carcinogenic to humans; Sufficient evidence in humans or sufficient evidence in animals
and strong mechanistic data in humans)
Group 2A – (Probably carcinogenic to human; Limited evidence in humans and sufficient evidence in
animals)
Draft, Deliberate, and Confidential
Step 2 con’t – Do any other classification
systems/organizations have appropriate levels of
evidence?
• Tier 2
– OEHHA Proposition 65 list chemicals
• “Cancer”
•
(http://oehha.ca.gov/prop65/prop65_list/files/P65single052413.pdf)
– NIOSH
• “Potential Occupational Carcinogen”
•
(http://www.cdc.gov/niosh/topics/cancer/npotocca.html)
Draft, Deliberate, and Confidential
Step 3 – Compile ALL substances that
correspond to these qualitative classifications
•
EPA (104 substances and chemicals)
–
–
–
–
•
1986 – Group A - 12, B1 - 5, B2 - 61;
1996 – 8
1999 – Carc. to Hum. – 1; Likely – 4
2005 – Carc. to Hum. – 1; Likely – 12
NTP (240 substances and chemicals)
– Known – 54
– Reasonable – 186
•
IARC (176 substances and chemicals)
– Group 1 – 111
– Group 2A – 65
•
OEHHA Proposition 65 (554 substances and chemicals)
– “Cancer” – 554
•
NIOSH (132 substances and chemicals)
– “Potential Occupational Carcinogen” - 132
Draft, Deliberate, and Confidential
Step 4 – Remove substances from the lists that
are not within scope of NSF/UL 440:
•
•
•
•
•
•
•
•
•
•
Biologicals such as bacteria and viruses
Food substances
Exposures to mixtures resultant from food preparation
Particulates
Radionuclides
Complex compositions such as wood smoke, diesel fuel, etc
Occupational chemical exposures
Medications and pharmaceuticals
Metals
Groupings of substances or chemicals without a defined CAS
Draft, Deliberate, and Confidential
Step 5 – Remove substances that are outside the volatility
range specified by CA 1350 (0.000227 – 514.1 mm Hg at 25C)
CA 1350 defines a VOC as:
Draft, Deliberate, and Confidential
Chemicals Excluded on the Basis of Volatility
Chemicals Excluded on
the Basis of Volatility
6-Nitrochrysene
1,3-Butadiene
Di(2-ethylhexyl)phthalate
(DEHP)
Dibenzo[a,i]pyrene
Dibenzo[a,h]pyrene
Dibenzo[a,l]pyrene
Dibenzo[a,e]pyrene
Indeno[1,2,3-cd ]pyrene
7H-Dibenzo[c,g]carbazole
Benzo[j]fluoranthene
Benzo[b]fluoranthene
Benzo[k]fluoranthene
Chrysene
Dibenz[a,h]acridine
Dibenz[a,j]acridine
Hydrazine/Hydrazine sulfate
5-Methylchrysene
1,6-Dinitropyrene
1,8-Dinitropyrene
Formaldehyde
Benzo[a]pyrene (BaP)
1-Nitropyrene
Benz[a]anthracene
4-Nitropyrene
Chlorinated paraffins (C12, 60%
chorine)
Vinyl chloride
Vinyl fluoride
Acetaldehyde
Ethylene Oxide
Propylene oxide
Benzidine (and dyes
metabolized to benzidine)
Dyes metabolized to 3,3'Dimethylbenzidine
CAS
Agency
Cancer TRVs (ug/m3)
7496-02-8
106-99-0
NTP, IARC
EPA 1999, NTP, IARC
yes
yes
117-81-7
EPA 1986, NTP
no
189-55-9
189-64-0
191-30-0
192-65-4
193-39-5
194-59-2
205-82-3
205-99-2
207-08-9
218-01-9
226-36-8
224-42-0
302-01-2
3697-24-3
42397-64-8
42397-65-9
50-00-0
50-32-8
5522-43-0
56-55-3
57835-92-4
NTP
NTP
NTP, IARC
NTP
EPA 1986, NTP
NTP
NTP
EPA 1986, NTP
EPA 1986, NTP
EPA 1986
NTP, IARC
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes
yes; 1.3E-05
yes
yes
yes
yes
63449-39-8
NTP
75-01-4
75-02-5
75-07-0
75-21-8
75-56-9
EPA 1986, EPA 1996, NTP, IARC
NTP, IARC
EPA 1986, NTP, IARC
NTP, IARC
EPA 1986, NTP
92-87-5
EPA 1986, NTP, IARC
yes
NTP
no
EPA 1986, NTP
NTP
NTP
NTP
EPA 1986, NTP, IARC
EPA 1986, NTP, IARC
NTP, IARC
EPA 1986, NTP
NTP
Blue = on Al’s list, Green = on HPDB
Draft, Deliberate, and Confidential
no
yes
no
yes; 2.2E-06
yes
yes
Step 6 – Remove chemicals that:
1) are not on Al Hodgson’s
061212 spreadsheet
2) are not a chemical component
in building products or
furnishings listed in the
Household Products Database
or 3) do not have a cancer TRV
Draft, Deliberate, and Confidential
Step 7 – Identify the Inhalation Unit Risks for the
remaining chemicals
Draft, Deliberate, and Confidential
List of Carcinogenic Chemicals from EPA
• EPA (Tier 1) – 10 out of 104
•
plus 5 not found in HPDB or as an emission on Al’s spreadsheet
List of Chemicals from EPA
Remaining
Chemicals
CAS
Agency
Epichlorohydrin
106-89-8
EPA 1986
1,2-Dibromoethane
106-93-4
EPA 1999
Acrylonitrile
107-13-1
EPA 1986
1,4-Dioxane
123-91-1
EPA 2005
Chloroprene
126-99-8
EPA 2005
Tetrachloroethylene
127-18-4
EPA 2005
1,3-Dichloropropene
542-75-6
EPA 1986
Bis(chloromethyl)ether
(BCME)
542-88-1
EPA 1986
Carbon tetrachloride
56-23-5
Aniline
62-53-3
Benzene
Inhalation Cancer TRVs
(EPA, OEHHA, WHO; HC;
WHO; ug/m3)
Citation
2.30E-05; 1.20E-06
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
7.10E-05; 2.20E-04; 0.6
2.90E-04; 6.80E-05
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
7.70E-06
OEHHA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
5.00E-04
EPA - http://www.epa.gov/iris/subst/1021.htm; 0<2 yrs - 8.6E-5; 2-16 yrs - 1.8E-4; 16-70 yr - 2.3 E-4
5.90E-06; 2.60E-07; 2E-06 to 2E-05
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0106.htm; NAP http://www.nap.edu/openbook.php?record_id=12863&page=98
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0224.htm
1.6E-5; 4.0E-6
1.3E-02; 6.2E-02; 9.43
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); EPA - http://www.epa.gov/iris/subst/0375.htm; Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
EPA 2005
4.2E-05; 1.5E-05; 6E-06
OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA -http://www.epa.gov/iris/subst/0020.htm
EPA 1986
1.60E-06
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf
71-43-2
EPA 1986, EPA
1996
Dichloromethane
75-09-2
EPA 2005
2.9E-05; 8.3E-06; 2.2E-06 to 7.8E-6; 6E-06OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0276.htm#carc; WHO http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
1.0E-08; 2.3E-05
EPA - http://www.epa.gov/iris/subst/0070.htm#carc; Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
Trichloroethylene
79-01-6
EPA 2005
Acrylamide
79-06-1
EPA 2005
1.3E-03; 1.3E-03; 1E-04
1,2,3-Trichloropropane
96-18-4
EPA 2005
None
•
2.0E-06; 4.1E-06; 6.1E-04; 4.3E-07
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0199.htm#carc; Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM; WHO http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0286.htm#carc
None
Blue = on Al’s list, Green = on HPDB
Draft, Deliberate, and Confidential
List of Carcinogenic Chemicals from NTP
• NTP (Tier 1) – 13 out of 240
•
plus 5 not found in HPDB or as an emission on Al’s spreadsheet
List of Chemicals from NTP
Remaining
Chemicals
CAS
Agency
Inhalation Cancer TRVs
(EPA, OEHHA, WHO; HC;
WHO; ug/m3)
Citation
Styrene
100-42-5
NTP
4.60E-05
OEHHA for styrene oxide, a major metabolite of styrene (http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf)
1,4-Dichlorobenzene
106-46-7
NTP
1.10E-05
OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf)
2.30E-05; 1.20E-06
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
7.10E-05; 2.20E-04; 0.6
Epichlorohydrin
106-89-8
NTP
1,2-Dibromoethane
106-93-4
NTP
Acrylonitrile
107-13-1
NTP
2.90E-04; 6.80E-05
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
1,4-Dioxane
123-91-1
NTP
7.70E-06
OEHHA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
NTP
5.00E-04
EPA - http://www.epa.gov/iris/subst/1021.htm; 0<2 yrs - 8.6E-5; 2-16 yrs - 1.8E-4; 16-70 yr - 2.3 E-4
5.90E-06; 2.60E-07; 2E-06 to 2E-05
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0106.htm; NAP http://www.nap.edu/openbook.php?record_id=12863&page=98
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0224.htm
Chloroprene
126-99-8
Tetrachloroethylene
127-18-4
NTP
1,3-Dichloropropene
542-75-6
NTP
Bis(chloromethyl)ether
(BCME)
542-88-1
NTP
Carbon tetrachloride
56-23-5
Thiourea
62-56-6
1.3E-02; 6.2E-02; 9.43
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); EPA - http://www.epa.gov/iris/subst/0375.htm; Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
NTP
4.2E-05; 1.5E-05; 6E-06
OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA -http://www.epa.gov/iris/subst/0020.htm
NTP
2.10E-05
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf
Benzene
71-43-2
NTP
Dichloromethane
75-09-2
NTP
Trichloroethylene
79-01-6
NTP
Acrylamide
79-06-1
NTP
Naphthalene
91-20-3
1,2,3-Trichloropropane
96-18-4
•
1.6E-5; 4.0E-6
2.9E-05; 8.3E-06; 2.2E-06 to 7.8E-6; 6E-06OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0276.htm#carc; WHO http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
1.0E-08; 2.3E-05
EPA - http://www.epa.gov/iris/subst/0070.htm#carc; Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
2.0E-06; 4.1E-06; 6.1E-04; 4.3E-07
1.3E-03; 1.3E-03; 1E-04
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0199.htm#carc; Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM; WHO http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
OEHHA;
EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0286.htm#carc
NTP
3.40E-05
OEHHA - http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf
NTP
None
None
Blue = on Al’s list, Green = on HPDB
Draft, Deliberate, and Confidential
List of Carcinogenic Chemicals from IARC
• IARC (Tier 1) – 5 out of 176
•
plus 2 not found in HPDB or as an emission on Al’s spreadsheet
List of Chemicals from IARC
Remaining
Chemicals
CAS
Agency
Epichlorohydrin
106-89-8
IARC
Tetrachloroethylene
127-18-4
IARC
Bis(chloromethyl)ether
(BCME)
542-88-1
IARC
Benzene
71-43-2
IARC
Trichloroethylene
79-01-6
IARC
Acrylamide
79-06-1
NTP
1,2,3-Trichloropropane
96-18-4
IARC
•
Inhalation Cancer TRVs
(EPA, OEHHA, WHO; HC;
WHO; ug/m3)
Citation
2.30E-05; 1.20E-06
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
5.90E-06; 2.60E-07; 2E-06 to 2E-05
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0106.htm; NAP http://www.nap.edu/openbook.php?record_id=12863&page=98
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); EPA - http://www.epa.gov/iris/subst/0375.htm; Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
1.3E-02; 6.2E-02; 9.43
2.9E-05; 8.3E-06; 2.2E-06 to 7.8E-6; 6E-06OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0276.htm#carc; WHO http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
2.0E-06; 4.1E-06; 6.1E-04; 4.3E-07
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0199.htm#carc; Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM; WHO http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
1.3E-03; 1.3E-03; 1E-04
OEHHA;
EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0286.htm#carc
None
None
Blue = on Al’s list, Green = on HPDB
Draft, Deliberate, and Confidential
Combined List of Chemicals from EPA, NTP, IARC
• EPA, NTP, and IARC (Tier 1) – 14 total
•
plus 5 chemicals not found in HPDB or as an emission on Al’s spreadsheet
Combined List of Chemicals from Tier 1 Agencies or Organizations
Remaining Chemicals
CAS
Agency
Inhalation Cancer TRVs (EPA,
OEHHA, WHO; HC; WHO;
ug/m3)
Citation
Styrene
100-42-5
NTP
4.60E-05
OEHHA for styrene oxide, a major metabolite of styrene (http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf)
1,4-Dichlorobenzene
Epichlorohydrin
106-46-7
106-89-8
NTP
EPA 1986, NTP, IARC
1,2-Dibromoethane
106-93-4
EPA 1999, NTP
1.10E-05
2.30E-05; 1.20E-06
7.10E-05; 2.20E-04; 0.6
Acrylonitrile
1,4-Dioxane
Chloroprene
107-13-1
123-91-1
126-99-8
EPA 1986, NTP
EPA 2005, NTP
EPA 2005, NTP
Tetrachloroethylene
127-18-4
EPA 2005, NTP, IARC
1,3-Dichloropropene
Bis(chloromethyl)ether (BCME)
542-75-6
542-88-1
EPA 1986, EPA 1996, NTP
EPA 1986, NTP, IARC
1.6E-5; 4.0E-6
1.3E-02; 6.2E-02; 9.43
Carbon tetrachloride
56-23-5
EPA 2005, NTP
4.2E-05; 1.5E-05; 6E-06
OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf)
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
OEHHA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
EPA - http://www.epa.gov/iris/subst/1021.htm; 0<2 yrs - 8.6E-5; 2-16 yrs - 1.8E-4; 16-70 yr - 2.3 E-4
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0106.htm; NAP http://www.nap.edu/openbook.php?record_id=12863&page=98
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0224.htm
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); EPA - http://www.epa.gov/iris/subst/0375.htm; Health
Canada -EPA
http://wwwOEHHA;
- http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA -http://www.epa.gov/iris/subst/0020.htm
Aniline
Thiourea
62-53-3
62-56-6
EPA 1986
NTP
Benzene
71-43-2
EPA 1986, EPA 1996, NTP, IARC
1.60E-06
2.10E-05
2.9E-05; 8.3E-06; 2.2E-06 to 7.8E-6; 6E-06
Dichloromethane
75-09-2
EPA 2005, NTP
Trichloroethylene
79-01-6
EPA 2005, NTP, IARC
Acrylamide
79-06-1
EPA 2005, NTP, IARC
1.3E-03; 1.3E-03; 1E-04
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf
OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0276.htm#carc; WHO http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
EPA - http://www.epa.gov/iris/subst/0070.htm#carc; Health Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0199.htm#carc; Health
Canada - http://wwwesd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTHCANADA.HTM; WHO http://www.euro.who.int/__data/assets/pdf_file/0009/128169/e94535.pdf
OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA - http://www.epa.gov/iris/subst/0286.htm#carc
Naphthalene
1,2,3-Trichloropropane
91-20-3
96-18-4
NTP
EPA 2005, NTP, IARC
3.40E-05
None
OEHHA - http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf
None
2.90E-04; 6.80E-05
7.70E-06
5.00E-04
5.90E-06; 2.60E-07; 2E-06 to 2E-05
1.0E-08; 2.3E-05
2.0E-06; 4.1E-06; 6.1E-04; 4.3E-07
•
Blue = on Al’s list, Green = on HPDB
Draft, Deliberate, and Confidential
List of Carcinogenic Chemicals Derived from OEHHA
Proposition 65 Listings
(if not already considered in Tier 1 list)
• OEHHA proposition 65 list (Tier 2) – 10 out of 554
–
–
–
–
Plus 1 chemical not found in HPDB or as an emission on Al’s spreadsheet
Blue field = found as a product emission on Al’s spreadsheet
Light Green field = found in HPDB
Orange cell = found in HPDB in a product that MAY be associated with building products or furnishings
List of Chemicals from Tier 2 Agencies or Organizations that haven't been Considered by the Tier 1 Agencies
Chemicals
CAS
Methyl isobutyl ketone
Ethylbenzene
Diethanolamine
Benzophenone
Ethyl acrylate
108-10-1
100-41-4
111-42-2
119-61-9
140-88-5
OEHHA prop 65
OEHHA prop 66
OEHHA prop 65
OEHHA prop 65
OEHHA prop 65
Hydrazine
302-01-2
OEHHA prop 65
Propylene glycol mono-t -butyl ether
Coconut oil diethanolamine condensate
o -Phenylphenol
1,3-Dichloro-2-propanol (1,3-DCP)
Cumene (isopropyl benzene)
57018-52-7
68603-42-9
90-43-7
96-23-1
98-82-8
OEHHA prop 65
OEHHA prop 65
OEHHA prop 65
OEHHA prop 65
OEHHA prop 65
Agency
Cancer TRVs
(ug/m3)
Citation
2.50E-06
OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf)
4.9 E-03; 4.9E-03
OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909. pdf);
http://www.epa.gov/iris/subst/0352.htm
• NIOSH (Tier 2) – 0 out of 132
Draft, Deliberate, and Confidential
Should we include the chemicals from the
Tier 2 organizations?
•
CA 1350 draws from the Proposition 65 list for some of its target VOCs (“known or probable human carcinogens
and reproductive/developmental toxins”)
•
Methylisobutyl ketone, ethylbenzene, 1,3 DCP, and isopropyl benzene in Al’s list of chemicals emitted from
building products or furnishings
•
Diethanolamine and ethylacrylate listed as components in building products (HPDB)
•
Benzophenone, benzaldehyde, and cyclohexanone emitted from the UV-cured lacquer of French coated oak
parquet flooring (Formation of organic indoor air pollutants by UV-curing chemistry. Salthammer, T.; Bednarek, M.;
Fuhrmann, F.; Funaki, R.; Tanabe, S.-I. Journal of Photochemistry and Photobiology A: Chemistry vol. 152 issue 1-3
September 20, 2002. p. 1-9; in addition to the Prop 65 listing, benzaldehyde has some evidence of cancer in mice
studies and cancer cluster in Ohio, NTP study of Benzoph. Was done via oral ingestion)
•
Propylene glycol mono-t-butyl ether used in water-based paints (Choi et al, 2010), in adhesives, and in waterreducible coatings (NTP, 2004)
•
Cocamide diethanolamine primarily used in personal care products (shampoos, hand soaps, and cosmetics), so
delete?
•
o-polyphenol used primarily as a fungicide or germicide in fruits and vegetables, so delete?
•
Hydrazine in rocket and other fuels, not in building products, so delete?
Draft, Deliberate, and Confidential
Final list of 29? Chemicals combining
Tier 1, Tier 2, and Aldehydes
Extra
Tier 2
Tier 1
(* indicates that a cancer unit risk does not exist)
Styrene
100-42-5
1,4-Dichlorobenzene
Epichlorohydrin
106-46-7
106-89-8
1,2-Dibromoethane
106-93-4
Acrylonitrile
1,4-Dioxane
107-13-1
123-91-1
Chloroprene
126-99-8
Tetrachloroethylene
127-18-4
1,3-Dichloropropene
542-75-6
Bis(chloromethyl)ether (BCME)
542-88-1
Carbon tetrachloride
56-23-5
Aniline
Thiourea
62-53-3
62-56-6
Benzene
71-43-2
Dichloromethane
75-09-2
Trichloroethylene
79-01-6
Acrylamide
79-06-1
Naphthalene
1,2,3-Trichloropropane*
Methyl isobutyl ketone*
Ethylbenzene
Diethanolamine*
Benzophenone*
Ethyl acrylate*
Propylene glycol mono-t -butyl ether*
1,3-Dichloro-2-propanol (1,3-DCP)*
Cumene (isopropyl benzene)*
91-20-3
96-18-4
108-10-1
100-41-4
111-42-2
119-61-9
140-88-5
57018-52-7
96-23-1
98-82-8
Formaldehyde
50-00-0
Acetaldehyde
75-07-0
OEHHA for styrene oxide, a major metabolite of styrene
(http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf)
OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf)
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); Health Canada - http://www7.10E-05; 2.20E-04; 0.6
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTH
2.90E-04; 6.80E-05
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
7.70E-06
OEHHA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf)
EPA - http://www.epa.gov/iris/subst/1021.htm; 0<2 yrs - 8.6E-5; 2-16 yrs - 1.8E-4; 16-70 yr 5.00E-04
2.3 E-4
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA 5.90E-06; 2.60E-07; 2E-06 to 2E-05
http://www.epa.gov/iris/subst/0106.htm; NAP OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA 1.6E-5; 4.0E-6
http://www.epa.gov/iris/subst/0224.htm
OEHHA; EPA (http://oehha.ca.gov/risk/pdf/APENDX-B.pdf); EPA 1.3E-02; 6.2E-02; 9.43
http://www.epa.gov/iris/subst/0375.htm; Health Canada - http://wwwOEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA 4.2E-05; 1.5E-05; 6E-06
http://www.epa.gov/iris/subst/0020.htm
1.60E-06
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf
2.10E-05
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf
OEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA 2.9E-05; 8.3E-06; 2.2E-06 to 7.8E-6; 6E-06 http://www.epa.gov/iris/subst/0276.htm#carc; WHO EPA - http://www.epa.gov/iris/subst/0070.htm#carc; Health Canada - http://www1.0E-08; 2.3E-05
esd.worldbank.org/popstoolkit/POPsToolkit/POPSTOOLKIT_COM/TOOLS/HHRA/SF_HEALTH
OEHHA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA 2.0E-06; 4.1E-06; 6.1E-04; 4.3E-07
http://www.epa.gov/iris/subst/0199.htm#carc; Health Canada - http://wwwOEHHA; EPA - http://oehha.ca.gov/risk/pdf/APENDX-B.pdf; EPA 1.3E-03; 1.3E-03; 1E-04
http://www.epa.gov/iris/subst/0286.htm#carc
3.4E-05;
OEHHA - http://oehha.ca.gov/risk/pdf/TCDBcas061809.pdf
.
.
.
2.50E-06
OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf)
.
.
.
.
.
.
.
.
.
.
.
.
OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf);
6E-06; 1.3E-5
http://www.epa.gov/iris/subst/0419.htm
OEHHA (http://oehha.ca.gov/air/hot_spots/pdf/CPFs042909.pdf);
2.7E-06; 2.2E-06
http://www.epa.gov/iris/subst/0290.htm
4.60E-05
1.10E-05
2.30E-05; 1.20E-06
Draft, Deliberate, and Confidential