The ENSAT-CANCER Project: from European to
Global Biomedical Research Collaborations
Professor Richard O. Sinnott
Director eResearch & Chair Applied Computing Systems
University of Melbourne
4th December 2014
rsinnott@unimelb.edu.au
Completed
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Project Portfolio
National e-Science Centre (I, II, III)
Dynamic Virtual Organisations for e-Science Education
Biomedical Research Informatics Delivered by Grid Enabled Services
GridNet, GridNet-2
Grid Enabled Microarray Expression Profile Search
Glasgow early adoption of Shibboleth
Joint Data Standards Survey
ESP-Grid
HPC Compute cluster award // Sun industrial sponsorship
OGC Collision
OMII-Security Portlets // OMII-RAVE
Integrating VOMS and PERMIS for Superior Grid Authorization
NCeSS
CESSDA PPP
Pharming of Therapeutic RNA
Grid Enabled Occupational Data Environment
Towards an e-Infrastructure for e-Science Digital Repositories
Grid enabled Biochemical Pathway Simulator
Virtual Organisations for Trials and Epidemiological Studies
A European e-Infrastructure for e-Science Repositories
Modelling, Inference and Analysis for Biological Systems up to the Cellular Level
Drug Discovery Portal
Parliamentary Discourse
Scots Words and Placenames
Qvolution stress management survey system
Advanced Grid Authorisation through Semantic Technologies ShinTau
AlstromUK VRE
Grid-enabled Virtual Safe Settings
Clinical Streaming Transcription Software
Enhancing Repositories for Language and Literature Researchers (ENROLLER)
Proxy Credential Auditing Infrastructure for the NGS
Scottish Bioinformatics Research Network (SBRN)
Generation Scotland Scottish Family Health Study
Breast Cancer Tissue Biobank
Data Management through e-Social Science (DAMES)
Meeting the Design Challenges of nanoCMOS Electronics (nanoCMOS)
EU FW7 AvertIT
EU FW7 EuroDSD
NeSC Research Platform (NRP)
NeSC Information Network (NIN)
ESF Network for Study of Adrenal Tumors
Scottish Health Informatics Platform for Research (SHIP)
National E-Infrastructure for Social Simulation (NeISS)
EU R4SME Diagnosis of Parkinsons Disease (DiPAR)
Automating River Pollution Detection (CAPIM)
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On-Going
EU European Platform for Study of Wolfram, Alstrom,
Bardet Biedl
Multicenter prospective study of biochemical profiles
of monoamine-producing tumors (PMT Study)
European Society of Hypertension Study on
Pheo/PGL
International DSD
EU FW7 European Network for Study of Adrenal
Tumors Cancer Research Platform
VicHealth Health Indicators and Spatial Objective
Data
National Spinal Injury Research Platform
Australian Urban Research Infrastructure Network
(AURIN)
DSDNetwork Australasia
Epilepsy e-Learning portal
Type-1 Diabetes study of environmental factors on
onset of T1D (Adelaide/NHMRC)
Endocrine Genomics Virtual Laboratory (endoVL)
Australian Diabetes Data Network
Open stack Cloud Encryption and Deletion
ERA-NET Cushing Syndrome
International Niemann-Pick A, B and C Registry
Carlton Connect Data Journalism in the Big Data Era
FAMIAN - Combined 18F-fluorodeoxyglucose
positron emission tomography and 123IIodometomidate Imaging for Adrenal Neoplasia
CRE for Protection of Pancreatic Beta Cells
Airbox (Atmospheric Physics and Climate Research)
ENSAT-CANCER
• European Network for Study of Adrenal Tumours (ENSAT –
www.ensat.org) CANCER
– 6m Euro; 5-year project;
• Started 2011 – end 2015
• Funds one software developer (@UniMelb)
– Focus on 4 types of tumour
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Adrenocortical carcinoma (ACC)
Aldosterone Producing Adenoma (APA)
Non-aldosterone cortical adrenal adenomas (NAPACA)
Pheochromocytomas and related paragangliomas (Pheo)
– Requirements
– These are rare (ACC ~1-2 cases per million pop.)
• Secure web-based tumour databases
– Integration of existing resources in Italy, France, Germany, UK, …
• Biobanking
• Imaging
• Clinical trials
– Originally two identified in grant!
• Seamless interactions between all of these
ENSAT-CANCER
ENSAT-CANCER
Research
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Publications (100+)
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Nature Genetics (multiple)
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New England Journal of Medicine (multiple)
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Journal of Clinical Endocrinology and Metabolism
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Journal of Nuclear Medicine
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Journal of Endocrinology
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Journal of Human Molecular Genetics
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International Journal of Cancer
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Journal of Molecular and Cellular Endocrinology
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European Journal of Endocrinology
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Journal of Cancer Cell
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Journal of Clinical Cancer Research
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International Journal of Clinical Chemistry
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Journal of Hormone and Metabolic Research
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Journal of Modern Pathology
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Journal of Hypertension
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European Journal of Cancer
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Journal of Annals of Clinical Biochemistry
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Journal of Endocrine-related cancer
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Journal of the National Cancer Institute
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American Journal of Cancer Research
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UniMelb Research
• Publications
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A.J. Stell, R.O. Sinnott, J. Jiang. Enabling Secure, Distributed
Collaborations for Adrenal Tumor Research, HealthGrid
conference, Paris, France, June 2010.
R.O. Sinnott, A.J. Stell, Towards a Virtual Research
Environment for International Adrenal Cancer Research,
Workshop on Biomedical and Bioinformatics Challenges to
Computer Science, International Conference on
Computational Science, Tsukuba, Japan, June 2011.
A.J. Stell, R.O. Sinnott, A novel, secure biobanking repository
to support distributed studies of rare adrenal tumors,
eResearch New Zealand, June 2011.
R.O. Sinnott, A.J. Stell, A Virtual Research Environment for
International Adrenal Cancer Research, eResearch
Australasia, Melbourne, Australia, November 2011.
A.J. Stell, R.O. Sinnott, The ENSAT Registry: A Digital
Repository Supporting Adrenal Cancer Research, Health
Informatics Conference (HIC), Sydney, Australia, July 2012.
R.O. Sinnott, A.J. Stell, Beyond a Disease Registry: An
Integrated Virtual Environment Supporting Adrenal Cancer
Research, submitted to Journal of Human Mutation,
Sep2014.
S. Glöckner, W. Arlt, I. Bancos, A. Stell, R.O. Sinnott,
Improving Data Quality in Disease Registries and Clinical
Trials: A Case Study from the ENSAT-CANCER Project, 8th
Australasian Workshop on Health Informatics and Knowledge
Management, Sydney, Australia, January 2015.
R. Därr, C. Pamporak, M. Peitzsch, K. Miehle, A. Prejbisz, D.
Weismann, F. Beuschlein, R.O. Sinnott, S. Bornstein, H.
Neumann, A. Januszewicz, J. Lenders, G. Eisenhofer,
Biochemical diagnosis of phaeochromocytoma using plasma
free normetanephrine, metanephrine and methoxytyramine:
Importance of supine sampling under fasting conditions,
Journal of Clinical Endocrinology, 2013
• Other
– Grants
• endoVL, ADDN, INPDR,
MGHA, …
– Students
• PhDs
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Tracy McLean
Stephan Gloeckner
Sehrish Kanwal
Farah Khan
Yang Lu
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• MScs
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iPhone Apps
Android Apps
Sample tracking
Cloud logging/auditing
Machine learning on the
Cloud
– Machine learning on HPC
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(Current) H2020 Activities
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ENSAT-HT – Omics-based strategies for improved diagnosis and treatment of endocrine
hypertension
– (Full proposal submitted)
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ENSAT-AIM - European Network for the Study of Adrenal Tumours – Creating a Novel
Diagnostic Tool for Adrenal Incidentaloma Management
– (EoI submitted)
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ENSAT-ACC - European Network for the Study of Adrenal Tumours – Adrenocortical Cancer
Consortium
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(EoI submitted)
Treat Wolfram – Development of a new therapy for Wolfram syndrome
– (EoI submitted)
Expectation of NHMRC co-funding (if funded!)