Table S2 List of functionally annotated domain of 429 HPs from H. influenzae by CATH, SUPERFAMILY, PANTHER, Pfam, SYSTERS, CDART SVMProt and ProtoNet S.NO UNIPROT ID CATH SUPERFAMIL Y PANTHER families Pfam (family/Domain) SYSTERS (cluster) CDART SVMProt (family) ProtoNet Cluster (cluster name) Cluster146746 Arsenic efflux pump TC 2.A. Electrochemi cal Potentialdriven transporters Porters (uniporters, symporters, antiporters) Cluster 3631830 Sodium/sul fate symporter DUF493 superfamily All lipid binding proteins Cluster 3959135 (subfamily/fa mily /superfamily ) 1 2 3 4 Q57048 P44465 P44471 P44472 No result No result UPF0250 protein MCA0107 like domain family YbeD-like family ATPase synthesis protein 25, mitochondri al -like domain family Putative transport protein YidE -like Iojap/YbeB-like family 2oxoglutarate/ malate translocator subfamily Sodium: sulfate symporter transmembrane family No result DUF493 family (2oxoglutarat e/malate translocator ) Cluster 156264 (hypothetic al protein) (Nucleotidyl transferase) TrkA C-terminal domain-like family Iojap superfamily ortholog family Oligomerization family Cluster 153016 Uncharacteri zed family TrkA_c family Cluster(Regulator of K+ 151662 conductance, Cterminal) (Aspartate: Oligomeriza Iron binding tion superfamily (Iojap related protein) TrkA_c superfamily Transmembr ane Protein of unknown function DUF493 Cluster 4170010 Iojap related protein YidE/YbjL duplication (cation transport) 5 6 7 8 P43929 P43931 P44477 P44478 domain ½ family Regulator of Hypothetical ribonuclease protein VC0424 activity B family like domain family No result No result No result No result RraB family (Regulator of ribonuclease activity B Domain) Calcium ATPase, transmembrane domain M family No result No result Bax inhibitorrelated family Bax1-I family No result YtfJ_HI0045 family No result DUF697 family alanine antiporter) Cluster155970 DUF695 superfamily mRNA slicing (DNA for Glycosyltra nsferases, lytic transglycos ylase, dTDP-4rhamnose reductase) Cluster – 149616 Cluster 3251533 Conserved hypothetica l protein CHP01619 (catalytic activity) DUF697 superfamily EC 4.1.-.-: Lyases CarbonCarbon Lyases Cluster 418116 (GTPbinding protein) cluster 141641 B-I-1 like superfamily Transmembr ane (Putative carrier/tran sport protein) cluster 144963 (Protein YTFJHI0045 superfamily No result Conserved hypothetica l protein CHP01620 Cluster 3845992 Uncharacte rized protein family UPF0005 Cluster 3999593 Conserved 9 P44484 No result No result Family not named DctQ family ytfJ precursor ) Cluster 140419 Dct-Q superfamily Transmembr ane SBP_bac_7 superfamily EC 2.4.-.-: Transferases Glycosyltran sferases (Serpentine receptor class alpha 3) 10 11 12 P71336 P43932 P44492 No result No result Replicationassociated protein -like domain family Phosphate binding proteinlike family No result SBP_bac_7 family (Bacterial extracellular solute-binding protein) Cluster147378 Cluster144352 TerC superfamily Transmembr ane (TerC family protein ) Cluster149840 AAA superfamily Iron-binding Calcium ATPase, transmembrane domain M family Inner membrane protein family Integral membrane protein TerC family YjeE-like family (P-loop containing nucleoside triphosphate hydrolases superfamily) No result Uncharacterized P-loop hydrolase UPF0079 family (Extracellul ar solutebinding protein, family 7) (ATPase OR kinase) hypothetica l protein, YtfJ Tripartite ATPindependen t periplasmic transporter, DctQ component Cluster 4180508 Extracellul ar solutebinding protein, family 7, bacteria Cluster 4019065 Integral membrane protein TerC Cluster 4166012 Uncharacte rized protein family UPF0079, 13 P43935 No result 14 P43936 mRNA interferase MazF -like domain family 15 P44500 Deoxyribon uclease TatD -like domain family 16 P43937 17 P43938 MiaE-like family Ferredoxin(Ferritin-like related superfamily ) family Kid/PemK family (Cell growth inhibitor/plasmid maintenance toxic component superfamily) TatD Mgdependent DNase-like family No result Acyl-CoA dehydrogen ase -like domain family Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains family No result No result No result No result TATD family deoxyribonu clease Protein of unknown function (DUF455) family PemK-like protein family Cluster148957 (3-oxoacyl[acylcarrierprotein] synthaselike protein) Cluster133513 Ferritin like superfamily EC 2.7.-.-: Transferases Transferring PhosphorusContaining Groups PemK Zinc binding superfamily (toxin of the (Hypothetic ChpB-ChpS al protein toxinyifN) antitoxin system) TatD_DNase ClusterMetallo_de Zinc-binding family 149137 pendent_hy drolases (Hydrolase, superfamily TatD family) Acyl-CoA_dh_N ClusterACDA Metalfamily 109390 superfamily binding (Acyl-COA dehydrogenase (Putative ,N-terminal acyl-CoA domain) dehydrogen ase) No result Cluster No result All DNA ATPase bacteria Cluster 3942395 Protein of unknown function DUF455 Cluster 3597088 Plasmid maintenanc e toxin/Cell growth inhibitor Cluster 4150200 Deoxyribon uclease, TatD Mgdependent Cluster 4673817 Eukaryota Cluster 18480 binding (hypothetic al protein) 18 19 20 21 P44506 P44507 Q57493 P44509 Alanine racemase like domain family "Hypothetical" protein ybl036c family (PLP-binding barrel superfamily) Proline synthetase cotranscribed bacterial homolog protein family Glycerate kinase -like domain family Glycerate kinase I family Glycerate Gly_kinase kinase family family No result No result No result Ala_racemase_N Clusterfamily 140661 PLPDE_III superfamily Metal binding Gly_kinase superfamily EC 2.7.-.-: Transferases Transferring PhosphorusContaining Groups TC 2.A. Electrochemi cal Potentialdriven transporters Porters All DNA binding (Alanine (Putative racemase, NProline terminal domain) synthetase associated protein) Cluster155132 (glycerate kinase) No result gnt family gluconate transporter family GntP permease family No result Diacid_rec family (Putative sugar diacid recognition ) Cluster145230 PRK10034 superfamily (gluconate permease) Cluster – 147588 (carbohydr ate diacid regulator) Diacid_rec superfamily 651650 Haemophil us influenzae Cluster 4106519 Predicted pyridoxal phosphatedependent enzyme, YBL036C type Cluster 4144170 Glycerate kinase, domain 2 Cluster 3750408 Divalent ion symporter Cluster 4157002 Putative sugar diacid 22 23 24 25 26 P43939 Q57060 P43940 P44515 Q57354 No result Ribosomal protein L11 methyltransf erase -like domain family No result Regulatory protein spx like domain family No result UbiE/COQ5-like family (S-adenosyl-Lmethioninedependent methyltransferas es superfamily ) No result ArsC-like family (Thioredoxinlike suprerfamily) UPF0135 NIF3 (NGG1p protein ybgI interacting factor -like domain 3)-like family 2 family NAD dependent epimerase/de hydratase Family GntP permease family Cluster142884 Methyltransf erase family Methyltransf_11 family (nucleoside diphosphat e sugar epimerase) Cluster – 141931 No result No result NGG1 interacting factor 3 superfamily No result Arsc family NADB_Ros sman superfamily AdoMet_M Tases superfamily (SAM dependent methyltrans ferase) Cluster – No result 113245 recognition Cluster 4107863 EC 2.4 Transferases glycosyltrans NAD ferases dependent epimerase/ dehydratase Zinc binding Cluster 3952797 Methyltran sferase type 11 All lipid binding proteins (lipoprotein ) Cluster – GST_C_fa All lipid 148069 mily binding Superfamily protein (Arsenate reductase) NIF3 family Cluster – (NGG1p 144114 interacting factor 3) (NGG1interacting NIF3 superfamily Ec 4.1 layasescarboncarbon lyases Cluster 3845090 Haemophil us influenzae Cluster 4139373 Conserved hypothetica l protein ,ArsC related Cluster 3959512 NIF3 (NGG1p interacting factor 3) 27 P44520 No result No result No result 28 P43943 Lipopolysac charide biosynthesis protein -like domain family FepE-like family (Bacterial polysaccharide co-polymeraselike superfamily ) No result 29 P71339 Myb-related protein -like domain ½ family Homeodomainlike/TrpR-like superfamily No result 30 Q57097 SUMOactivating enzyme subunit 1 like domain ½ family Molybdenum cofactor biosynthesis protein MoeB family Ubiquitin activating enzyme E1 family No result No result No result 31 P43947 DUF1212 family Cluster – 145492 (Putative integral membrane protein ) Cluster104440 GTP_EFTU family (Elongation factor Tu GTP (transcripti binding domain ) on elongation factor ) HTH_28 family Cluster – (Helix-turn-helix 142986 domain) (putative transposase ) ThiF family Cluster – 141827 (Molybden um biosynthesi s protein) DUF2301 family Cluster – 112930 (putative factor 3 like Protein of unknown function DUF 1212 Nucleotidyl _cyc_III superfamily Transmembr ane No result Ec-2.7 Transferases Phosphorus containing group Cluster 3393659 Haemophil us HTH_23 superfamily RNA binding protein Cluster 360664 Acid phosphatas e E1_enzyme _family superfamily Transmembr ane DUF2301 superfamily , zf-ribbon_3 Transmembr ane Cluster 4090928 UBA/THIF -type NAD/FAD binding fold Cluster 3939039 Gammaprot eo bacteria 32 33 34 35 36 P44530 P43952 P44540 P44542 P44543 No result No result Bifunctional protein glk like domain family/ Glucose-6phosphate isomerase like domain ½ family No result No result No result No result Xanthin/urac il/vit C permease family member Permease family No result AsmA_2 Family (Asm-A like Cterminal region ) mono-SIS domain family /Homeodomainlike superfamily Glucokinase family Phosphate binding proteinlike family No result No result HTH_6 family (Helix turn helix ,rpiR family ) Family not integral membrane protein) Cluster – 147664 (xanthin/ur acil permease) Cluster – 140134 (Penicillin binding protein ) Cluster – 144388 superfamily No result Transmembr ane Cluster 4145036 Xanthin/ura cil/vit C permease No result Transmembr ane Cluster 3742698 pasteurellac eae SIS superfamily Transferases – transferring alkyl or aryl group , other than methy group Cluster 4192755 Helix turn helix protein RpiR SBP_bac_7 superfamily All lipid binding protein DctQ Transmembr Cluster 4180508 Extracellul ar solute binding protein , family 7 , bacteria Cluster (transcripti onal regulator , RpiR family ) SBP_bac_7 family Cluster – 147377 (Bacteria extracellular solute binding protein ) (C-4 dicarboxyla te binding protein ) DctQ family Cluster – named 147373 (Tripartite ATPindependent periplasmic transporter) 37 O86220 No result No result No result Got1/Sft2-like family 38 P43953 No result No result Protein-S Isoprenylcyst eine Omethyltransf erase family PEMT family Band 7 protein related family SPFH domain , Band 7 family Phosphopant etheinyl transferase family ACPS family (4'phosphopantethe inyl transferase superfamily) 39 40 P44545 P43954 No result Holo-[acylcarrierprotein] synthase like domain family Band 7/SPFH domain family 4'Phosphopantethe inyl transferase SFP family (Phospholipid methyl transferase ) superfamily (permease component of C-4 dicarboxyla te transporter ) Cluster No result 18576 (hypothetic al protein) Cluster – PEMT 146297 superfamily (putative protein-Sisoprenyl cysteine methyltrans ferase ) Cluster – Band_7 143375 superfamily (HFLC protein ) Cluster – 115344 (putative 4’phosphopa ACPS superfamily ane 4101809 TRAP dicarboxyla te transporter , DctM subunit Transmembr ane No result Photosynthe sis Cluster 4548116 C-terminal protein amino acid methylation EC-3.4 hydrolases – acting on peptide bonds Metal binding family Cluster 4131544 HFLC Cluster 4098210 4’phosphopa ntetheinyl transferase 41 42 43 44 45 P43790 P43960 P44552 P44553 P43961 No result No result No result No result No result No result Putative uncharacteri zed protein like domain family CNF1/YfiH-like putative cysteine hydrolases superfamily Uncharacteri zed family YFIH Mitochondri a fission 1 protein -like domain family Tetratricopeptide No result repeat (TPR) family No result NE1680likefamily No result DUF 177 family DUF539 family Cu-oxidase_4 family (multi-copper polyphenol oxidoreductase laccase ) YfiO family (Outermembrane protein lipoprotein domain) LPAM_1 family (Prokaryotic membrane lipoprotein lipid ntetheinyl transferase) Cluster – 156287 DUF 177 superfamily No match (predicted metal binding ) Cluster – 133282 DUF539 superfamily Transmembr ane Cu_oxidase _4 superfamily All lipid binding protein No result All lipid binding protein (putative periplasmic protein ) Cluster – 154635 (putative inner membrane protein ) Cluster – 154926 (putative competence protein ComL) Cluster – No result 121456 (P36 like protein All lipid binding protein Cluster 4143789 Protein of unknown function DUF177 Cluster 4129373 Protein of unknown function DUF539 Cluster 4170210 multicopper polyphenol oxidoreduct ase laccase Cluster 4133061 Outer membrane assembly lipoprotein YfiO Cluster 3750388 Periplasmic protein HI0178 46 P46490 No result No result Transmembr ane protein YfcA family attachment site motif) Sulfite exporter TauE/SafE family homolog) Cluster – 150623 PRK10621 super family Transmembr ane No result Transferases – transferring phosphorus containing group Y1_Tnp superfamily All lipid binding protein Cluster 4081513 Proteobacte ria Cluster – 156419 DUF417 superfamily Transmembr ane (putative membrane protein ) Cluster – 149074 UDG like superfamily Transmembr ane Cluster 4017619 Protein of unknown function DUF417 Cluster 4097728 Uracil DNA (transporter protein ) 47 48 49 50 P43963 P43965 P44577 O86222 No result Transposase for insertion sequence element IS200 -like domain family No result racil-DNA glycosylase -like domainfami No result Transposase IS200-like family No result No result RecX family Transposases IS200 like family Cluster – 65234 (predicted transcriptio nal regulator , Fis family ) Cluster – 156161 (YAFM protein) No result Mug-like family (Uracil-DNA glycosylaselikesuperfamily) No result No result DUF417 family UDG family (Uracil DNA glycosylasesuper family ) (Uracil Cluster 4629881 Protein of unknown function DUF81 Cluster 638968 Haemophil us influenzae ly 51 52 53 54 55 P44579 P44583 P43966 P43968 P44588 No result Multidrug resistance efflux transporter EmrE family Putative chloramphen icol resistance transporter family No result uncharacteri sed family 185 -like domain YhcH-like family (Clavaminate synthase-like superfamily) General stress protein A like domain family Glycogenin No result family/Galactosy ltransferase LgtC family No result No result (Nucleotidediphospho-sugar transferases superfamily ) No result No result No result No result Multidrug resistance efflux transporter family (EmrE family ) Domain of unknown function (DUF386) family No result DNA glycosylase ) Cluster145543 DUF331 family EmrE superfamily Transmembr ane Cluster 4593188 RarD protein DUF386 superfamily EC 2.4.-.-: Transferases Glycosyltran sferases Cluster 3982124Co nserved hypothetica l protein CHP00022 Glyco_tranf EC 1.9.-.-: _GTA_type Oxidoreduct Superfamily ases - Acting on a heme group of donors Cluster 3612942 Biotin-[acetylCoAcarboxylase ] ligase No result No result DUF 3331 superfamily Zinc binding Cluster 801874 Haemophil us influenzae Cluster 4325097 (RarD protein) Cluster156379 (Evolved betagalactosida se betasubunit) Cluster48523 (hypothetic al membrane lipoprotein) No result glycosylase Cluster120053 (hypothetic al protein ) Cluster133502 (putative regulator) 56 57 58 59 60 P44593 P43971 P43972 P71346 P44606 Sulfurtransf SirA-like family erase TusA -like domain family No result Iron-sulfur cluster repair protein YtfE -like domain family Formin homology 2 domain (FH2 domain) family No result No result No result No result Ribosomal subunit interface protein -like domain family 1-(5- Sulfurtransferase TusA family Hemerythrin family (Hemerythrin HHE cation binding domain) Ribosome binding protein Y (YfiA homologue) family No result FMN-linked tRNA- LAM_1 family Cluster145561 SirA_YedF Metal_YeeD binding Superfamily (Hypothetic al protein yeeD) ClusterHemerythri All DNA125947 n-like binding Superfamily (Methylaccepting chemotaxis protein mcpB) ClusterNo result No result 120058 (Prokaryotic membrane lipoprotein lipid attachment site motif) (Protein HI0246 precursor) Ribosomal_S30 AE family Cluster150719 RaiA superfamily Sodiumbinding Dus family (Sigma-54 modulation protein) Cluster- TIM_phosp EC 3.5.-.-: Protein of unknown function DUF331 Cluster 4048585 SirA-like Cluster 4146242 Haemerythr in/HHE cationbinding motif Cluster 3854887 Uncharacte rised conserved protein UCP02077 2 Cluster 3863398 Keyword 9863 Cluster 61 62 63 64 P43975 P44609 P43980 P43982 phosphoribo syl)-5-[(5phosphoribo sylamino)m ethylidenea mino] -like domain family Phosphogly cerol transferase I -like domain family oxidoreductases family Dihydrouridi ne synthase family Arylsulfatase family No result UPF0225 protein MCA2786 like domain family SEC-C associated NTF2-like domain family/Sec-C motif family VC0467-like family UPF0301 protein MCA2336 2 -like domain family No result No result No result 147656 Sulfatase family SEC-C family Uncharacteri zed protein YQGE family DUF179 family No result MarB protein family hate_bindin Hydrolases g Acting on (TIM barrel Superfamily Carbonproteins ) Nitrogen Bonds, other than Peptide Bonds 4154178 TRNAdihydrourid ine synthase Cluster151986 Sulfatase Transmembr Superfamily ane Cluster 4276704 Sulfatase (putative integral membrane protein ) Cluster147600 SEC-C superfamily Zinc-binding Cluster 4127137 SEC-C motif TC 2.A.1 Major facilitator family (MFS) Cluster 4164891 Protein of unknown function DUF179 Cluster 4596145 Proteobacte ria (Hypothetic al protein HI0277) ClusterDUF179 151233 superfamily (transcripti onal regulator ) Cluster97759 (Merozoite surface protein-3) No result Transmembr ane 65 P44634 UPF0082 YebC-like protein family At2g25830 like domain family Uncharacteri zed family Transcrip_reg family 66 P43984 No result No result No result Isoprenylcystein e carboxyl methyltransferas e (ICMT) family 67 P44640 No result No result No result Na_H_antiport_ 2 family 68 P43987 No result MW0975(SA094 No result 3)-like family 69 P44641 L-lysine MoCo lysine 2,3- Cluster152835 (Glucose-1phosphate adenylyltra nsferase) ClusterPEMT 146292 superfamily Cluster 4120159 Protein of unknown function DUF28 Cluster 3831400 Protein-S(Farnesyl isoprenylcy cysteine steine Ocarboxylmethyltrans methyltrans ferase ferase) activity ClusterNa_H_antip TC 2.A. Cluster 149200 ort_2 Electrochemi 3390635 Superfamily cal Potential- Na+/H+ (Putative driven antiporter integral transporters - NhaC-like membrane Porters protein) (uniporters, symporters, antiporters) priB_priC family Cluster156082 Fer4_14 family Transcrip_r All lipideg binding Superfamily proteins (Primosom al replication protein N) Cluster- Transmembr ane priB_priC superfamily No result Cluster 4045251 Pasteurellal es Radical_SA Iron-binding Cluster 70 71 72 73 74 P44646 P44649 P24324 Q57065 P43989 2,3aminomutas e -like domain family biosynthesis proteins family No result No result No result No result aminomutase like family Transmembr ane protein family No result uncharacteri sed family 154 -like domain ½ family Alpha-2,3/8sialyltransferase CstII family No result SinR domainNo result like family (lambda repressor-like DNA-binding domains superfamily) Tetratricopeptide No result Receptor- No result 133235 Lig_chan family (Ligand-gated ion channel) Dehydratase_he m family CST-I family HTH_25 family (Helix-turn-helix domain) TPR_21 family (L-lysine 2,3aminomuta se) Cluster140871 (Putative transport protein) Cluster128738 (splicing factor like protein ) Cluster142738 (Alpha-2,3sialyltransf erase) Cluster150265 (Putative DNAbinding protein) Cluster- M Superfamily 4031921 Protein of unknown function DUF160 yhhT Transmembr Superfamily ane (Predicted permease) Cluster 4138321 Uncharacte rised protein family UPF0118 Cluster 4074320 Protein of unknown function DUF469 Cluster 4094607 Alpha2,3/8sialyltransf erase CstII Cluster 4174733 Helix-turnhelix type 3 DUF469 Zinc-binding Superfamily ,Sulfotransf er_3 Superfamily CST-I Lipoprotein Superfamily HTH_XRE All lipidSuperfamily binding proteins TPR All lipid- Cluster 75 P44668 76 P44670 associated repeat (TPR) protein of family the synapse -like domain ½ family uncharacteri IscX-like family sed family 163 -like domain No result SMI1/KNR4like family 144927 No result Fe-S_assembly family No result DUF2625 family Cluster133422 P44672 Iron-sulfur HesB-like cluster domain family insertion protein erpA -like domain family FeS cluster assembly protein family Fe-S_biosyn family 78 P44675 HTH-type transcription al regulator NsrR -like domain family RNA (cytidine/uri dine-2'-O-)methyltransf No result Rrf2 family 79 P44676 SpoU-like RNA 2'-O ribose methyltransferas e family 4156687 Tetratricop eptide-like helical FeS_assembly superfamily Cluster 4639845 Hypothetic al protein yfhj (Colicin protein) 77 Z-DNA binding domain family Superfamily binding proteins RNA methyltransf erase family SpoU rRNA Methylase family Cluster156071 (FeS cluster assembly) Zinc-binding DUF2625 All lipidSuperfamily binding proteins (Hypothetic al protein) ClusterFeIron-binding 145453 S_biosyn superfamily (Iron-sulfur cluster assembly protein) ClusterRrf2 Zinc-binding 139965 Superfamily (transcripti onal regulator) Cluster149834 SpoU_meth EC 2.1.-.-: ylase Transferases Superfamily (tRNA/rRN Transferring Cluster 3836505 Bacteria Cluster 4138459 FeS cluster insertion Cluster 4164851 Transcripti onal regulator, Rrf2 Cluster 4156967 RNA methyltrans 80 P44679 81 P43990 82 P43992 83 84 P43994 P44683 erase -like domain family 1,4dihydroxy2naphthoylCoA hydrolase like domain family Acetate kinase -like domain ½ family 4HBT-like family (Thioesterase/thi ol ester dehydraseisomerase superfamily) Family not named Thioesterase superfamily YeaZ-like family (Actin-like ATPase domainsuperfam ily) oGlycoprotease sialoglycopro family tein endopeptidas e family Rhamnogala cturonan acetylestera se -like domain family Rhamnogalactur onan acetylesterase family (SGNH hydrolase superfamily) No result uncharacteri sed family 256 -like domain MoaD/ThiS superfamily No result Lysine- Asparaginyl No result RnfH family Ubiquitin A One-Carbon methyltrans Groups ferase) Clusterhot_dog Zinc-binding 149566 Superfamily (4hydroxyben zoyl-CoA thioesterase ) ClusterCOG1214 143405 Superfamily (Glycoprot ein endopeptid ase) ClusterNo result 93419 (Putative transcriptio nal regulatory protein) Cluster155495 EC 3.4.-.-: Hydrolases Acting on peptide bonds (Peptidases) All lipidbinding proteins Ub-RnfH SodiumSuperfamily binding (Protein rnfH) mina53 (myc Cupin Cluster- Cupin_2 EC 3.1.-.-: ferase TrmH, group 1 Cluster 4145117 4hydroxyben zoyl-CoA thioesterase Cluster 4162826 Peptidase M22, glycoprotea se Cluster 4167654 Acyltransfe rase 3 Cluster 4150562 (Uncharact erised protein family UPF0125) Cluster specific demethylase NO66 -like domain ½ family/ 85 86 87 P44684 P44686 P44691 hydroxylase-like family (Clavaminate synthase-like superfamily)/ Dachshund like domain Dachshundfamily homology domain family (Putative DNAbinding domainsuperfam ily) RNA MutT-like pyrophosph family (Nudix ohydrolase - superfamily) like domain family UPF0234 protein Rv0566c/M T0592 -like domain family No result Vitamin B12 import system permease ABC transporter involved in vitamin B12 uptake, BtuC induced nuclear antigen) family superfamily protein 150111 (Mina53) udp/adpNUDIX family sugar pyrophosphat ase family Cluster 147294 No result Cluster94128 ABCtransporter metalbinding DUF406 family ABC 3 transport family (Pyrophosp hohydrolas e) (Similar to Ikaros/Heli os (Fragment) ) Cluster149307 (ABC Superfamily Hydrolases Acting on Ester Bonds 3887799 Cupin 4 Nudix_Hyd EC 3.6.-.-: rolase Hydrolases Superfamily Acting on Acid Anhydrides Cluster 4127686 Nucleoside diphosphat e pyrophosph atase Cluster 4482597 Conserved hypothetica l protein CHP00743 DUF406 superfamily EC 2.4.-.-: Transferases Glycosyltran sferases TM_ABC_i ronsiderophore s_like Transmembr ane Cluster 4098632 ABC 3 88 89 90 91 92 P44693 Q57392 P43995 P44702 P44709 protein BtuC -like domain family Lipoprotein -like domain family Outer membrane protein -like domain family Sodium/pot assiumtransporting ATPase subunit gamma -like domain family tRNA (adenineN(6)-)methyltransf erase -like domain family uncharacteri sed family 27 -like family protein family Peptidoglycan hydrolase LytM family (Duplicated hybrid motif superfamily) Outer membrane protein family Peptidaserelated family Ribbon-helixhelix superfamily No result No result Peptidase family M23 Opacity family transporter) Superfamily Cluster138457 Peptidase_ EC 3.4.-.-: M23 Hydrolases Superfamily Acting on peptide bonds (Peptidases) OMP_b-brl Photosynthe Superfamily sis Cluster 4184571 Peptidase M23B DUF1778 superfamily Cluster 4095373 Protein of unknown function DUF1778 (Peptidase, M23/M37 family) Cluster150900 Opacity protein DUF1778 family Cluster152250 (Putative helix-turnhelix protein) N5-glutamine methyltransferas e, HemKfamily Methyltransf erase family Methyltransf_26 family Cluster145157 (Omethyltrans ferase) No result No result DUF416 family Cluster133516 EC 4.1.-.-: Lyases CarbonCarbon Lyases Cluster 3846753 Opacity AdoMet_M EC 3.1.-.-: Tases Hydrolases Superfamily Acting on Ester Bonds Cluster 4119785 Methyltran sferase small DUF416 superfamily Cluster 3848570 Protein of All DNAbinding domain family 93 P31777 94 P44711 95 P43997 96 97 P43998 P44717 Ribosomal RNA small subunit methyltransf erase G like domain family UPF0133 protein Rv3716c/M T3819 -like domain family No result No result KpsF protein -like domain ½ family/ UDP-Nacetylenolp yruvoylgluc (Hypothetic al protein ) S-adenosyl-Lmethioninedependent methyltransferas es superfamily No result YbaB-like family No result No result Ribosomal RNA small subunit methyltransferas e D, RsmJ family Cluster152634 No result YbaB/EbfC DNA-binding family Cluster152197 (YbaB protein) YbaB_DNA All lipid_bd binding Superfamily proteins Cluster 4110991 Keyword 10025 No result LPAM_1 family Cluster120106 No result All lipidbinding proteins Cluster 3988855 Pasteurellal es Lipoyl Cluster 3948648 Proteobacte ria No result CorC/HlyC Hemolysindomain-like related family (FADfamily binding/transport er-associated domain-like superfamily)/ No result CBS family (Cystathionine beta synthase) No result DNA repair unknown function DUF416 Cluster 3854691 Protein of unknown function DUF519 (Florfenicol resistance protein) (Hypothetic al protein) ClusterNo result 145440 (fucosyltra nsferase) Cluster143846 (Hemolysin protein) CBS_pair Transmembr Superfamily ane Cluster 4144744 Transporter -associated region 98 99 100 101 102 P43999 P44718 P44720 Q57144 P44000 osamine reductase like domain family No result Deoxyribon uclease TatD -like domain family Zinc finger protein 425 -like domain family No result RNA- CBS-domain pair family No result TatD Mgdependent DNase-like family (Metallodependent hydrolases superfamily) No result No result Aminomethyltra No result Tatd family deoxyribonu clease DUF1523 family Cluster140145 TatD_DNase family (ABC transporter subunit) Cluster149137 (Hydrolase, TatD family) Uncharacteri zed family No result Uncharacteri YceG-like family UreF family GCV_T Cluster152447 (Aminodeo xychorisma te lyase (PABC)) Cluster155241 (VirK virulence protein) Cluster- DUF1523 superfamily Transmembr ane metalloNo result dependent_ hydrolases Superfamily YceG-like family superfamily Zinc-binding DUF535 Iron-binding Superfamily /ANK Superfamily ygfZ_signat DNA repair Cluster 3869536 Protein of unknown function DUF1523 Cluster 4150200 Deoxyribon uclease, TatD Mgdependent Cluster 4125861 Aminodeox ychorismat e lyase Cluster 4047417 Protein of unknown function DUF535 Cluster modifying nsferase folateprotein ygfZ binding domain -like domain family family zed family family 103 P44726 No result No result Uncharacteri zed family YicC-like family 104 P44003 Betaglucoside operon antiterminat or -like domain ½ family No result PTS-regulatory domain, PRD family No result PRD family 105 106 P44005 O05023 Nucleic acid binding protein -like domain family No result Retroviral integrase, catalytic domain family (Ribonuclease H-like superfamily) No result SNARE_assoc family Ferrichrome rve_3 family iron receptorrelated family 144469 ure Superfamily (aminomet /GCV_T_C hyltransfera Superfamily se) ClusterYicC_N Structural 148892 Superfamily protein (Matrix (stressprotein,Core induced protein,Viral protein) occlusion body,Keratin ) ClusterNo result Nuclear 146476 Receptors (26S proteasome regulatory subunit) Cluster141550 (Alkaline phosphatas e) Cluster142960 (Transposa se) SNARE_ass Transmembr oc ane Superfamily 4142011 Folatebinding, YgfZ Cluster 4144576 Region of unknown function DUF1732 Cluster 3622930 PTSregulatory domain, PRD Cluster 4334463 SNARE associated Golgi protein rve DNA Cluster Superfamily recombinatio 4067283 n Integrase, catalytic core 107 P44733 No result Myosin rod DNA fragments family recombinatio n protein rmuc family RmuC family 108 P44010 No result No result No result UPF0114 family 109 P44740 Nefassociated protein 1 like domain family YaeB-like family Uncharacteri zed family UPF0066 family 110 P44743 ncharacteriz ed protein HI_0520 like domain family MoCo biosynthesis proteins family (Radical SAM enzymes superfamily) Pyruvate formatelyaseactivating enzyme family Fer4_12 family 111 P44744 Formate PFL-like family No result Rad17 family Cluster147263 RmuC All DNASuperfamily binding (DNA recombinati on protein rmuC homolog) ClusterUPF0114 133284 Superfamily / AAA (transmemb Superfamily rane ) EC 2.4.-.-: Transferases Glycosyltran sferases Cluster 4170267 RmuC Cluster 4036464 Uncharacte rised protein family UPF0114 ClusterUPF0066 EC 2.5.-.-: Cluster 143774 Superfamily Transferases 4130990 Uncharacte (Formylmet Transferring rised hanofuran Alkyl or protein dehydrogen Aryl Groups, family ase) Other than UPF0066 Methyl Groups ClusterRadical_SA Iron-binding Cluster 146582 M 4152683 Superfamily (Pyruvate formatelyase 2 activating enzym) ClusterPFL Iron-binding Cluster 112 Q57256 acetyltransf erase -like domain family (PFL-like glycyl radical enzymes superfamily) No result No result 156410 (Yjji protein) No result Uncharacterized BCR, YitT family Cluster151901 Superfamily (Pyruvate formate lyase) No result Transmembr ane (YCZE protein) 113 114 115 P44012 P44013 P44014 Ribonucleas e -like domain family Ribonuclease Rh-like family No result No result Transposase for insertion sequence element IS200 -like domain Transposase IS200-like family Ribonuclease Ribonuclease T2 T2 family family No result No result G6PD_bact family Y1_Tnp family Cluster150158 (Ribonucle ase T2 family) Cluster142546 (Sugar ABC transporter, sugarbinding protein) Cluster45444 (Putative glycosyl transferase) RNase_T2 All lipidSuperfamily binding proteins 4053911 Glycyl radical enzyme, HI0521, predicted Cluster 4161004 Protein of unknown function DUF161 Cluster 4158722 Ribonuclea se Rh; Chain A G6PD_bact Zinc-binding Superfamily Cluster 3854686 Bacteria Y1_Tnp EC 2.7.-.-: Superfamily Transferases Transferring PhosphorusContaining Cluster 3969029 Complete proteome 116 117 118 119 120 Q57409 O86226 P44016 P44754 P44759 family No result No result No result 30S ribosomal protein S4 like domain family No result No result No result Heat shock protein 15 kD family (Alpha-L RNAbinding motif superfamily) Fusion Fibrinogen glycoprotein coiled-coil and F0 -like central regions domain family No result No result Family not named DUF1304 family Cluster156164 No result OPT family RNA pseudouridyl ate synthase family protein S4 family No result MerR-DNAbind family DUF1304 superfamily Groups All lipidbinding proteins (transmemb rane protein ) ClusterNo result 95821 (Putative sugar transporter) Cluster142428 (Oligopepti de transporter, OPT family) Cluster148435 EC 1.9.-.-: Oxidoreduct ases - Acting on a heme group of donors OPT Transmembr Superfamily ane (SlyX) Cluster 4106511 Oligopeptid e transporter OPT S4 RNASuperfamily binding Proteins Cluster 4003495 RNAbinding S4 SlyX TC 1.C. Superfamily Channels/Po res - Poreforming Cluster 4338006 SlyX (Heat shock protein 15) Cluster150246 Cluster 4069446 Protein of unknown function DUF1304 Cluster 4046743 Haemophil us family 121 122 123 124 125 P44761 P44017 P44018 P44019 P44023 No result No result No result HTH_22 family Sulfurtransf DsrH-like family No result erase TusD -like domain family DsrH family No result DcuC family No result No result Amidase signature (AS) enzymes family No result No result No result No result Ammonia monooxygenase AMO family Solute carrier DcuC family family 13 member Cluster138232 (Twocomponent sensor histidine kinase) Cluster156157 (DsrH protein ) Cluster149198 toxins (proteins and peptides) PAS_6 All lipidCluster Superfamily binding 4245364 proteins YheO-like DsrH TC 3.A.1 Superfamily ATP-binding cassette (ABC) family DcuC Transmembr Superfamily ane (C4dicarboxyla te transporter) ClusterDc-C Transmembr 149198 Superfamily ane (C4dicarboxyla te transporter) ClusterCOG1288 Transmembr 147973 Superfamily ane Cluster 3815209 Sulphur relay, TusB/DsrH Cluster 4107702 C4dicarboxyla te anaerobic carrier-like Cluster 4041962 Haemophil us influenzae Cluster 4117458 C4- 126 127 128 129 P44771 P44782 P44025 P44026 Phosphogly colate phosphatase -like domain family/ Predicted hydrolases Cof family (HAD-like superfamily) HMP-PP phosphatase -like domain family No result Pseudouridine synthase RsuA/RluD family Succinate dehydrogen ase assembly factor 2, like domain family Chloride channel protein -like YgfY-like family family (Transporte r) Phosphoserin Hydrolase_3 e family phosphatase family Cluster139306 RNA pseudouridyl ate synthase family protein PseudoU_synth_ 2 Cluster137915 No result Sdh5 family HAD_like All lipidSuperfamily binding proteins (Hydrolase) PseudoU_sy Iron-binding nth Superfamily (Ribosomal large subunit pseudouridi ne synthase A) ClusterSdh5 Sodium150151 Superfamily binding dicarboxyla te anaerobic carrier-like Cluster 4086008 HAD superfamily hydrolaselike, type 3 Cluster 4188164 Pseudouridi ne synthase, RsuA and RluB/C/D/ E/F Cluster 4162414 Ygfy (Ygfy) Clc chloride channel family Chloride channel family Voltage_CLC family Cluster141500 Voltage_gat Transmembr ed_ClC ane Superfamily Cluster 3520476 Chloride domain family 130 131 132 133 134 P44027 P44796 P44028 P44807 P46494 UPF0234 protein Rv0566c/M T0592 -like domain family High frequency lysogenizati on protein HflD -like domain family No result tRNA threonylcarb amoyladeno sine biosynthesis -like domain family DNA topoisomera se -like domain Integrin beta tail domain family No result YcfC-like family No result Integrin_B_tail family Golgin subfamily A member 5 (Chloride channel protein) Cluster151454 (Capsid scaffolding protein) Cluster156056 transport PBPb Superfamily (Bacterial periplasmic transport systems) DUF489 Superfamily All lipidbinding proteins Transmembr ane Cluster 4141960 Conserved hypothetica l protein CHP00743 Cluster 3916515 YcfC-like (ycfC protein) No result No result YrdC-like family SUA5 family PhnA zincbinding domain family/ Prokaryotic dna topoisomeras e family Prokaryotic membrane lipoprotein lipid attachment site LPAM_1 family Cluster156185 Sua5_yciO_yrd C family Cluster145750 DUF1375 Photosynthe Superfamily sis (lipoprotein ) Sua5_yciO_ RNAyrdC binding Superfamily Proteins (Sua5/YciO /YrdC family protein) zf-C4_Topoisom ClusterTOPRIM Zinc-binding family 144826 Superfamily (DNA Cluster 4094730 Protein of unknown function DUF1375 Cluster 4038495 Sua5/YciO/ YrdC, Nterminal Cluster 4554047 Prokaryotic type I DNA 1/2/3 family 135 136 P44031 P44033 No result No result Prokaryotic DNA topoisomerase I, a C-terminal fragment family Glu-tRNAGln amidotransferase C subunit family No result topoisomer ase I) No result No result No result Gp49 family HipA_N family 137 P44034 No result No result 138 O86228 DNAbinding protein -like domain family ambda repressor- No result like DNAbinding domains superfamily HTH_3 family 139 P44812 No result Tropomyosin family Nucleopolyhedr ovirus P10 protein No result Couple_hipA family Cluster156920 (putative phage protein ) Cluster156136 (Protein hipA) Cluster154923 topoisomer ase Gp49 mRNASuperfamily binding Proteins HipA_N Zinc-binding Superfamily / HipA_C Superfamily Couple_hip Iron-binding A Superfamily Cluster 4727452 Protein of unknown function DUF891 Cluster 4088874 HipA-like, N-terminal Cluster 4033498 HipA, N(ComK) terminal ClusterHTH_XRE TC 9.A. Cluster 145529 Superfamily Incompletely 3898899 Characterize Helix-turn(Transcripti d Transport helix type 3 onal Systems regulator, Recognized Hth-3 transporters family) of unknown biochemical mechanism ClusterDUF904 All lipidCluster 138169 Superfamily binding 4106976 proteins Protein of 140 P44036 Mycothiol acetyltransf erase -like domain 1/2/3 family 141 P71356 No result 142 143 P44037 P44827 No result No result NPV_P10 family (A kinase anchor protein) N-acetyl N-terminal Acetyltransf_1 Clustertransferase, NAT acetyltransfer family 146722 family ase family (Acetyltran sferases) Multidrug Family not resistance efflux named transporter EmrE family EamA-like transporter family Peptide methionine sulfoxide reductase family No result PAS_7 family Pseudouridine synthase RsuA/RluD family Ribosomal large subunit pseudouridin e synthase bfamily Cluster144807 No result Iron-binding No result Transmembr ane No result EC 3.1.-.-: Hydrolases Acting on Ester Bonds (Integral membrane domain protein) Cluster19036 (hypothetic al protein ) PseudoU_synth_ 2 family Cluster141200 (Ribosomal large subunit pseudouridi ne synthase B) PseudoU_sy rRNAnth binding Superfamily Proteins unknown function DUF904 Cluster 4032240 Nacetyltransf erase activity Cluster 4048630 Protein of unknown function DUF6, transmembr ane Cluster 3826314 NAD(P)binding Rossmannlike Domain Cluster 4152309 Pseudouridi ne synthase, RsuA and RluB/E/F 144 145 146 147 148 Q57523 P44038 P44831 P44040 P71357 No result No result Outer membrane protein assembly factor yaeT -like domain family Regulator of ribonuclease activity B like domain family No result No result No result No result Hypothetical protein VC0424 family No result Family of unknown function (DUF490) Sorting and assembly machinery (sam50) protein family Bac_surface_Ag family No result RraB family Cluster143388 (Putative signal peptide protein) Cluster141007 DUF490 All lipidSuperfamily binding proteins Cluster 4141982 Protein of unknown function DUF490 Bac_surface Zinc-binding _Ag Superfamily Cluster 4169983 Bacterial surface antigen (D15) PRK11191 MetalSuperfamily binding Cluster 3797359 Uncharacte rised conserved protein UCP01819 3 Cluster 3904479 Pasteurellal es (outer membrane protein) Cluster155971 (yjgD protein) No result No result No result LPAM_1 family RelB family Cluster152724 No result Nickelbinding (utative lipoprotein) ClusterRelB All lipid150903 Superfamily binding proteins (Damageinducible protein Cluster 4023654 RelB antitoxin 149 150 151 152 153 P44041 P44839 P44842 P44844 P44043 No result RelE-like family No result Plasmid_stabil family DinJ) Cluster119867 (Capsid assembly protein) Cluster141110 RutC family YjgF/L-PSP protein yjgF family -like domain family Translation initiation inhibitor family Ribonuc_L-PSP family Elongation factor G like domain family Impactrelated family UPF0029 family No result No result YigZ N-terminal domain-like family (Ribosomal protein S5 domain 2-like superfamily/ EF-G C-terminal domain-like superfamily) No result No result (Probable translation initiation inhibitor) Cluster146637 COG3041 Repressor Superfamily YjgF_YER All lipid057c_UK11 binding 4_family proteins Superfamily UPF0029 superfamily Zinc-binding (Proline dipeptidase ) No result No result YihI family Cluster156394 (putative coproporph yrinogen III oxidase) DUF2489 family Cluster156197 Cluster 4099600 Addiction module toxin, RelE/StbE Cluster 4195840 Endoribonu clease LPSP Cluster 4126851 Uncharacte rised protein family UPF0029 YihI MetalSuperfamily binding Cluster 4040724 Protein of unknown function DUF414 DUF2489 superfamily Cluster 4020603 Transmembr ane 154 155 P44045 P44047 No result No result No result No result No result No result 156 P44854 Centrosoma l protein of 41 kDa -like domain family Single-domain sulfurtransferase family Family not named 157 P44863 Polysacchar ide deacetylase -like domain family Divergent polysaccharide deacetylase family Uncharacteri zed yibqrelated No result No result (putative coproporph yrinogen III oxidase) Cluster155912 (DNAbinding protein UL42) Cluster142291 Domain of unknown function DUF2489 No result Photosynthe sis Cluster 4138486 Multicoppe r oxidase, type 2 NADB_Ros Zinc-binding smann Superfamily Cluster 3507333 Haemophil us influenzae (nucleoside diphosphat e-sugar epimerases) Rhodanese ClusterRHOD All lipidfamily 143086 Superfamily binding proteins (Rhodanese -related sulfurtransf erase) Polysacc_deac_2 ClusterCE4_SF EC 3.4.-.-: family 133511 Superfamily Hydrolases Acting on (YibQ) peptide bonds (Peptidases) Cluster 4116016 Oxidized Rhodanese; domain 1 Cluster 4078228 Protein of unknown function DUF610, 158 159 160 P44864 P44048 P44050 161 P44869 162 P44052 Lipoprotein Peptidoglycan -like domain hydrolase LytM family family Probable Fe(2+)trafficking protein -like domain family Doublestrand break repair protein MRE11 like domain family Ribosomal RNA small subunit methyltransf erase D like domain family No result YggX-like family Peptidaserelated family No result Peptidase_M23 family Cluster139239 Iron_traffic family (Peptidase, M23/M37 family) Cluster156159 Peptidase_ Zinc-binding M23 Superfamily YibQ Cluster 4145059 Peptidase M23B Bacterial Fe(2+) trafficking Cluster 4093460 YggX-like Iron-binding (Protein yggX) Metallodependent phosphatases superfamily No result Metallophos_2 family Cluster87121 MPP_superf Iron-binding amily Superfamily Cluster 4733582 Metallopho sphoesteras e S-adenosyl-Lmethioninedependent methyltransferas es superfamily Methyltransf erase family Cons_hypoth95 family Cluster142947 AdoMet_M EC 2.1.-.-: Tases Transferases Superfamily (Methyltran Transferring sferase) One-Carbon Groups Cluster 4136223 Conserved hypothetica l protein CHP00095 DBL homology domain (DHdomain) family No result No result Cluster112385 Cluster 3971366 Complete proteome (Phosphoes terase) (Ser/Thr protein kinase) No result Lipoprotein 163 164 165 P44053 P44054 P44882 cAMPcAMP-binding dependent domain family protein kinase regulatory subunit -like domain ½ family No result No result No result Family not named cNMP_binding family Cluster143194 CAP_ED MetalSuperfamily binding Cluster 3773754 Cyclic nucleotidebinding No result Cluster 3598299 Protein of unknown function DUF81 Cluster 3976330 Uncharacte rised protein family UPF0149 Cluster 3946111 Uncharacte rised protein family UPF0259 Cluster 3929807 Thioesteras e superfamily (Transcripti onal activator, CrP family) Transmembr ane protein YFCA family YgfB-like family No result TauE family TerB-N family Cluster150623 (Integral membrane protein) Cluster156212 Metalbinding UPF0149 All lipidSuperfamily binding proteins (ygfB) 166 167 P44056 P44886 No result Acylcoenzyme A thioesterase 11 -like domain ½ No result Thioesterase/thio l ester dehydraseisomerase superfamily No result Cytosolic acyl coenzyme a thioester hydrolase Yip1 family (Golgi vesicular transport protein) Cluster80365 Thioesterase superfamily Cluster147823 No result Transmembr ane (Cytochro me oxidase II) (Acyl-CoA hydrolase) hot_dog EC 3.1.-.-: Superfamily Hydrolases Acting on Ester Bonds 168 169 P44897 P44898 family uncharacteri sed family 67 -like domain YejL-like family family No result Na_H_antiport_ 2 family Inner membrane protein yejM -like domain family Alkaline phosphatase family Arylsulfatase family Sulfatase family P44058 Cytosine deaminase like domain family Cytosine deaminase catalytic domain family Family not named CutC family 171 P44059 Dihydroorot ase -like domain 2 family No result No result No result No result No result P44900 DUF1414 All DNASuperfamily binding (yejL like ) 170 172 Cluster152675 No result SEN1_N family (helicase Sen1 is an RNA polymerase II termination Cluster151985 Sulfatase Transmembr Superfamily ane / DUF3413 Superfamily (hydrolase of alkaline phosphatas e superfamily ) ClustermetalloIron-binding 148111 dependent_ hydrolases (Ammelide Superfamily aminohydr olase) ClusterNo result No result 111725 (GTPase activator ) Cluster135315 (YIHD) DUF1040 CalciumSuperfamily binding Cluster 4020600 Uncharacte rised protein family UPF0352 Cluster 3463167 Membrane sulfatase, HI0842related Cluster 3692882 Haemophil us Cluster 3667317 Nocardiops aceae Cluster 3673366 Protein of unknown function 173 174 175 176 177 P31811 P44903 P44904 P44062 P44905 No result No result No result factor) Nucleolar RNAbinding protein, Nop10p family Cluster156393 (Putative LysR type transcriptio nal regulator with pssR) Cluster140481 DUF413 DNA repair Superfamily Putative multidrug resistance protein MdtD -like domain family LacY-like Major proton/sugar facilitator symporter family superfamily domaincontaining proteinrelated family Major Facilitator Superfamily No result No result SDH_alpha family (Serine dehydratase alpha chain) Cluster156227 ZapA family Cluster136610 ZapA Transmembr Superfamily ane (Kinectin (Fragment) ) Cluster- COG0212 No result Lactate Cell division protein ZapAlike family Methenyltetrahy Uncharacteri zed family No result ATPase (Multidrug resistance protein) 5- MFS TC 2.A. Superfamily Electrochemi cal Potentialdriven transporters Porters (uniporters, symporters, antiporters) SDH_alpha MetalSuperfamily binding (inner membrane protein) Repressor DUF1040 Cluster 4034123 Protein of unknown function DUF413 Cluster 4109456 Drug:hydro gen antiporter activity Cluster 4318831 Uncharacte rised protein family UPF0597 Cluster 4068282 Cell division protein ZapA-like Cluster utilization protein B like domain family drofolate synthetase family inhibitor/5formyltetrah ydrofolate cyclo-ligase family formyltetrahydro folate cycloligase family 178 P44908 No result No result No result YhhQ family 179 P44063 Lipopolysac charide biosynthesis protein -like domain family Bacterial polysaccharide co-polymeraselike family No result Baculo_E56 family 180 Q57022 Polypeptide Nacetylgalact osaminyltra nsferase 1 - Nucleotidediphospho-sugar transferases superfamily Glycosyltran sferase family Glycosyl transferase family 2 150145 Superfamily 4172270 5(5formyltetra formyltetra hydrofolate hydrofolate cyclocycloligase ligase) activity ClusterDUF165 TC 2.A. Cluster 156383 Superfamily Electrochemi 4290160 cal Potential- Protein of (Transporte driven unknown r) transporters - function Porters DUF165 (uniporters, symporters, antiporters) ClusterNo result Transmembr Cluster 148453 ane 4119936 Lipopolysa (Chain ccharide length biosynthesi determinant s protein (Polysacch aride antigen chain regulator)) ClusterGlyco_tranf EC 2.4.-.-: Cluster 139894 _GTA_type Transferases 4204043 Superfamily Glycosyl (Glycosyl Glycosyltran transferase, transferase) sferases family 2 181 182 P44064 P44065 like domain family Polypeptide Nacetylgalact osaminyltra nsferase 1 like domain family No result Nucleotidediphospho-sugar transferases superfamily No result No result No result Glycosyl transferase family 2 Cluster – 96009 (Glycosyl transferase ) No result Cluster – 100590 Glyco_tranf EC 3.1.-._GTA_type :HydrolasesSuperfamily scting on ester bond Cluster 3685481 No result Cluster 3685481 No result (Hypothetic al protein) 183 184 185 P44067 P71360 P44068 No result No result No result No result No result WzyC family Multidrug resistance efflux transporter EmrE family Acylmalonyl condensing enzymerelated family EamA-like transporter family N-type ATP pyrophosphatase s family No result DUF208 family Cluster – 155051 (O-Antigen ligase) Cluster144807 Wzy_C Transmembr Superfamily ane (O-antigen ligase) EamA Transmembr Superfamily ane (integral membrane protein ) Cluster – 15145 (Hypothetic al protein ) DUF208 Zinc binding Superfamily Glycosyl transferase family 2 Glycosyl transferase family 2 Cluster 4170778 O-Antigen ligaserealated Cluster3853107 Protein of unknown function DUF6, transmembr ane Cluster 4025260 Protein of unknown function 186 187 188 189 190 P44069 P44070 P44931 P44072 P44073 No result No result No result No result dCMP deaminase like domain family Deoxycytidylate deaminase-like family No result No result No result No result No result DoxX family Transmembr ane protein YFCA family TauE family Cytosine deaminase family dCMP cyt deam 1 family No result No result Cluster149076 (Integral membrane protein) Cluster – 150623 DoxX Transmembr Superfamily ane No result Transmembr ane (Transporte r) DUF721 family Cluster – 143335 (tRNA specific adenosine deaminase ) Cluster – 132995 (RNA replicase (fragment )) DUF2547 family Cluster – 132575 (WBS15 splice cytidine_de All lipid aminasebinding like protein Superfamily DUF208 Cluster 3059231 DoxX Cluster 4117461 Protein of unknown function DUF81 Cluster 4151600 CMP/dCM P deaminase , zinc binding DUF721 Metal Superfamily binding Cluster 3748936 Protein of unknown function DUF721 DUF2547 All lipid Superfamily binding proteins Cluster 4354641 Pasteurellal es 191 P44074 tRNA (mo5U34)methyltransf erase -like domain family GTPaseactivating protein -like domain 1/2/3/4/5/6/ 7/8/9/10/11/ 12/13 family S-adenosyl-Lmethioninedependent methyltransferas es superfamily Methyltransf erase family Methytransf 11 family PDZ domainlike superfamily Serine protease family s1c htra-related family Peptidase M50 family variant 3) Cluster – 143210 AdoMet_M Zinc binding Tases Superfamily (Mthyltrans ferase) 192 P44936 193 P44938 Undecapren Undecaprenyl yl diphosphate pyrophosph synthase family ate synthase -like domain family Dehydrodoli chyl diphosphate synthase family Prenyltransf family 194 P44075 No result Restriction endonucleaselike superfamily No result Domain of unknown function DUF559 family 195 P44076 No result Thioltransferase family No result Glutaredoxin family Cluster – 147367 S2P-M50 Transmembr Superfamily ane /Zinc /PDZ binding Superfamily Cluster 3959076 Methytrans ferase type 11 Cluster 4147222 Peptidase (Zinc M50 , metalloprot putativeass ease ) ociated zinc metallopept idase Cluster – CIS_IPPS EC 2.5.-.-: Cluster 136904 Superfamily Transferases 4159268 Di(Undecapre Transferring trans,polynyl Alkyl or cispyrophosph Aryl Groups, decaprenyl ate Other than cistransfera synthase ) Methyl se Groups Cluster – Restriction_ DNA Cluster 144166 endonucleas replication 4054936 e_like Domain of (DNA Superfamily unknown methylase) function DUF559 Cluster – COG4545 Outer Cluster407 142128 Superfamily membrane 1603 (Glutaredo xin) 196 197 198 199 P44940 P44077 P44078 P44941 No result No result No result Phytoene dehydrogen ase -like domain family/ Glutathionylsper midine synthase ATP-binding domain-like family No result Bifunctional glutathionyls permidine synthetase/a midaserelated family No result Iron-dependent repressor protein, dimerization domain family No result FAD/NAD(P)binding domain superfamily Electron transfer flavoproteinubiquinone oxidoreducta GSP_synth family Cluster – 144944 GSP_synth Iron-binding Superfamily (Glutathion ylspermidin e synthase) No result Cluster – 135599 (Lipoprotei n) DUF2251 family Cluster – 151329 No result Zinc-binding DUF2251 All lipidSuperfamily binding proteins (Replicatio n protein) HI0933_like family Cluster – 148689 (flavoprotei n) NAD_bindi All lipidng_8 binding Superfamily proteins Uncharacte rised conserved protein UCP03729 1, glutaredoxi n-related Cluster394 3042 Glutathiony lspermidine synthase Cluster408 1953 Gammaprot eobacteria Cluster431 8060 Uncharacte rised conserved protein UPC00705 0 Cluster 4145478 HI0933like protein 200 201 P44079 P44080 Pyridine nucleotidedisulfide oxidoreduct ase -like domain family No result No result se family Pili subunits superfamily No result No result No result N_methyl_2 family No result Cluster – 154385 (alpha-1,3mannosyltr ansferase mnn1) Cluster – 120178 No result Transmembr ane No result Transmembr ane (Hypothetic al protein ) 202 203 204 P44081 P44082 Q57120 No result No result No result No result No result Kis/PemI No result No result No result 10 TM Acyl Transferase domain found in Cas1p (Cas1_AcylT family ) Type II secretory pathway pseudopilin (PulG family) Antitoxin-MazE Cluster – 137834 DUF2572 Transmembr Superfamily ane (Serine protease) Cluster – 120180 No result (Hypothetic al protein) Cluster – VagC Cluster405 7757 Prepilintype cleavage/m ethylation, N-terminal Cluster414 0983 Prepilin peptidasedependent protein B, predicted Cluster366 9568 Pasteurella ceae Transmembr ane Cluster408 5812 Pasteurellal es Iron-binding Cluster406 addiction antidote family 205 P44954 uncharacteri sed family 128 -like domain YehU-like family No result Mei5 family 206 P44084 No result No result No result LPAM_1 family 207 P44085 No result No result No result No result 208 P44086 No result No result No result No result 209 Q57133 No result GNA1870 immunodominan t domain-like family No result Lipoprotein_5 family 210 P46455 No result No result No result Tic20-like 155736 Superfamily (Virulenceassociated protein B) Cluster – 133503 4538 Proteobacte ria UPF0270 Zinc-binding Superfamily Cluster410 7858 Hypothetic al upf0270 protein pa3463 Cluster384 9717 Pasteurellal es (yheU like ) Cluster – 151115 DUF1425 EC 3.8.-.-: Superfamily Hydrolases Acting on (lipoprotein Halide ) Bonds Cluster – No result All lipid120184 binding proteins (Hypothetic al protein ) Cluster – No result No result 19225 (Hypothetic al protein) Cluster – Lipoprotein 148872 _5 Superfamily (Transferri n binding protein 2) Cluster – DUF997 Cluster416 0927 Complete proteome No result All lipidbinding proteins Cluster 4628469 Transferrin receptor activity Transmembr Cluster397 protein family 211 212 213 214 Q57147 O86230 P44965 P43907 No result No result Tryptophan synthase like domain family/ Multidrug Family not resistance efflux named transporter EmrE family EamA-like transporter family Multidrug Family not resistance efflux named transporter EmrE family EamA-like transporter family FMN-linked oxidoreductases family TRNAdihydrouridi ne synthase family Dihydrouridine synthase (Dus family ) No result LPAM_1 family tRNAdihydrouridi ne synthase -like domain No result No result 156381 Superfamily ane (Integral membrane protein) Cluster – 143722 EamA Transmembr Superfamily ane (Tou6 like ) Cluster – 143722 EamA Transmembr Superfamily ane (Tou6 like ) Cluster – 147656 (TIMbarrel protein) Cluster – 133395 TIM_phosp Zinc-binding hate_bindin g Superfamily No result EC 3.1.-.-: Hydrolases Acting on 4290 Protein of unknown function DUF997 Cluster369 2408 Protein of unknown function DUF6, transmembr ane Cluster 3692408 Protein of unknown function DUF6, transmembr ane Cluster415 4178 TRNAdihydrourid ine synthase Cluster388 9417 Pasteurellal 215 216 P43908 P44972 No result No result No result No result Peroxide stress response protein YAAA family Toxin_65 family No result Haemolytic family (signal peptide protein ) Cluster – 151722 (Protein yaaA) Cluster – 151228 Ester Bonds DUF328 EC 2.5.-.-: Superfamily Transferases Transferring Alkyl or Aryl Groups, Other than Methyl Groups Haemolytic MetalSuperfamily binding (Hypothetic al protein ) 217 218 P44974 Q57134 Phosphogly Arylsulfatase cerol family transferase I -like domain (Alkaline phosphatase-like superfamily) ranscription RuvA domain 2elongation like superfamily factor, mitochondri al -like domain 1/2 family Inner membrane protein family Sulfatase family Family not named HHH_3 family Cluster – 151987 (Integral membrane protein) Cluster – 144900 (ComE operon protein 1) Sulfatase Transmembr Superfamily ane No result No result es Cluster412 0731 Protein of unknown function DUF328 Cluster411 4102 Protein of unknown function DUF37 Cluster420 0264 Sulfatase Cluster416 1060 Competenc e protein ComEA, helixhairpinhelix region 219 220 221 222 223 P44093 Q57151 P44094 P44095 P44992 No result YgbK-like family D-tagatose1,6bisphosphate aldolase family DUF1537 family Cluster – 149258 (ygbK like ) Hydroxypyr uvate isomerase like domain family Xylose isomerase-like superfamily CDPabequose synthase like domain family/ Tyrosinedependent oxidoreductases family NAD dependent epimerase/de hydratase family Epimerase family Putative cyclase family No result Cyclase family NAD dependent epimerase/d ehydratase family protein -like domain Kynurenine formamidas e -like domain family No result Hydroxypyru AP_endonuc_2 vate family isomerase family Cluster – 148356 (Hydroxyp yruvate isomerase) Cluster – 142884 (Nucleosid ediphosphat e-sugar epimerase) Cluster – 153826 DUF1537 EC 4.1.-.-: Superfamily Lyases CarbonCarbon Lyases AP2Ec EC 2.4.-.-: Superfamily Transferases Glycosyltran sferases Cluster416 0211 Protein of unknown function, DUF1537 Cluster415 1021 Hydroxypy ruvate isomerase NADB_Ros EC 1.1.-.-: smann Oxidoreduct Superfamily ases - Acting on the CHOH group of donors Cluster410 7863 NADdependent epimerase/ dehydratase Cyclase Transmembr Superfamily ane Cluster410 2526 Putative cyclase SBP_bac_7 EC 2.4.-.-: Superfamily Transferases - Cluster418 0508 Extracellul (Cyclase) Phosphate binding proteinlike family No result SBP_bac_7 family Cluster – 147377 224 225 226 227 P44993 P44994 P44097 P44098 No result No result No result Asparagine synthetase No result No result No result Class II glutamine Family not named Family not named No result Putative glutamine DctM family DctQ family YGGT family GATase_4 family (TRAPtype C4dicarboxyla te transport system, periplasmic component) Cluster – DctQ 147373 Superfamily Glycosyltran sferases ar solutebinding protein, family 7, bacteria Transmembr ane Cluster410 1809 TRAP dicarboxyla te transporter, DctM subunit (TRAP dicarboxyla te transporter, DctM subunit) Cluster – DctQ Transmembr 147376 Superfamily ane (Permease component of C4 dicarboxyla te transporter) Cluster – YGGT 154128 superfamily (YGGT family protein ) Cluster – 148742 Transmembr ane Gn_AT_II All lipidSuperfamily binding Cluster 4101809 TRAP dicarboxyla te transporter, DctM subunit Cluster413 3866 Protein of unknown function YGGT Cluster397 9557 [glutaminehydrolyzing ] -like domain ½ family 228 229 230 231 P44099 P44103 Q57498 P44104 amidotransferase s family (N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily) Origin P-loop recognition containing complex nucleoside protein 5 triphosphate like domain hydrolases family superfamily Transglutam Transglutaminas inase family e core family protein -like domain family Carboxymu conolactone decarboxyla se family protein -like domainfami ly AhpD-like superfamily No result No result amidotransfe rase yafj family No result proteins (glutamine amidotransf erase ) AAA_14 family Cluster – 151461 (ATPase) No result No result No result Transglut_core family CMD family No result Cluster – 148463 (Transgluta minase-like enzymes) Cluster – 147110 (Carboxym uconolacto ne decarboxyl ase) Cluster – 128052 (Type III restriction- Amidophos phoribosyl transferase AAA_14 EC 2.4.-.-: Superfamily Transferases Glycosyltran sferases Cluster415 4065 Nucleotide binding Transglut_c All lipidore binding Superfamily proteins Cluster351 3118 Transgluta minase-like CMD All lipidSuperfamily binding proteins Cluster413 4856 Alkylhydro peroxidase AhpD core No result Cluster375 5017 Gammaprot eobacteria Zinc-binding 232 233 P44106 P44107 No result No result Tail-associated lysozyme gp5, C-terminal domain family No result No result No result TypeIII_RM_me thfamily No result modificatio n system: methylase) Cluster – 102844 TypeIII_R All lipidM_meth binding Superfamily proteins (Hemolysin ) Cluster – No result 19264 All DNAbinding (Hypothetic al protein ) 234 235 236 P71367 P45019 P44110 Phosphogly Arylsulfatase cerol family transferase I -like domain family No result No result Inner membrane protein family Sulfatase family Terpenoid Uncharacteri cyclases/Protein zed family prenyltransferase s superfamily DUF423 family No result DUF441 family No result Cluster – 151987 Sulfatase Transmembr Superfamily ane (Membrane -associated metaldependent hydrolase) Cluster – 143810 DUF423 Transmembr Superfamily ane (Small membrane protein) Cluster – 156337 DUF441 superfamily (inner membrane Transmembr ane Cluster402 4927 DNA methylase N-4/N-6 Cluster403 9085 Sulfuric ester hydrolase activity Cluster405 7510 Sulfatase Cluster465 3268 Protein of unknown function DUF423 Cluster406 6607 Protein of unknown function protein) 237 238 239 P45026 P44111 P44112 240 P45071 241 P45074 BolA protein -like domain family BolA-like family BOLA-like proteinrelated family No result No result No result UPF0042 nucleotidebinding protein CMS1991 like domain family LPSassembly protein lptD -like domain family No result No result No result BolA family Cluster – 144957 BolA All DNASuperfamily binding (Transcripti onal regulator (BolA family)) DUF3884 family Cluster – No result 19279 LPAM_1 family P-loop containing nucleoside triphosphate hydrolases superfamily Uncharacteri zed family ATP_bind_2 family No result No result OstA family No result (Hypothetic al protein ) Cluster – LPAM_1 Hormone 120189 Superfamily (Hypothetic al protein ) Cluster – ATP_bind_ Metal156331 2 binding Superfamily (P-loopcontaining kinase) Cluster – 156101 (ABC superfamily OstA All lipidSuperfamily binding proteins DUF441, transmembr ame Cluster414 3345 BolA-like Cluster378 0104 Haemophil us influenzae Cluster409 2229 Pasteurellal es Cluster412 1952 ATPase, Ploopcontaining Cluster404 9509 Cell envelope biogenesis 242 P45075 No result No result No result LptC family (bind_prot) transport protein) Cluster – 156487 YhbN COG3117 Transmembr Superfamily ane (YrbK protein) 243 244 245 246 P45076 P45077 P45083 P44116 UPF0307 PSPTO4464-like protein yjgA family -like domain 1 family No result No result Uncharacteri zed protein TLDD AND PMBA family 1,4dihydroxy2naphthoylCoA hydrolase like domain family No result Putative modulator of DNA gyrase, PmbA/TldD family DUF615 family Cluster – 148809 DUF615 superfamily All DNAbinding No result All lipidbinding proteins (yjgA protein) PmbA_TldD family (PmbA protein) Thioesterase/thio Family not l ester named dehydraseisomerase superfamily 4HBT family Restriction endonuclease- DUF559 family No result Cluster – 155408 Cluster – 147916 hot_dog All lipidSuperfamily binding proteins (Thioestera se) Cluster – 144166 Restriction_ endonucleas Zinc-binding Cluster419 3210 Protein of unknown function DUF1239 Cluster415 6047 Uncharacte rised protein family UPF0307 Cluster416 2426 Peptidase U62, modulator of DNA gyrase Cluster417 7136 Phenylaceti c acid degradation -related protein Cluster 4054936 like superfamily (DNA methylase) 247 248 249 250 Q57252 P45085 P44117 P44119 UDP-Nacetylenolp yruvoylgluc osamine reductase like domain family/ FAD-linked D-lactate oxidases, Cdehydrogena terminal domain se family / FADbinding/transport er-associated domain-like/ alpha-helical ferredoxin superfamily NADHquinone oxidoreduct ase subunit I -like domain family AT4G10000 Thioltransferase protein -like family domain ½ family FAD_binding_4 family Glutaredoxin family DUF496 family Triger factor/SurA peptide-binding domain-like superfamily No result No result No result No result FAD_bindi Zinc-binding ng_4 Superfamily (Oxidoredu ctase) Glutaredoxin -related protein family AT4G10000 protein -like domain ½ family Cluster – 140820 e_like Superfamily Cluster – 141965 (Glutaredo xin-related protein) Cluster – 152251 Thioredoxin EC 2.4.-.-: _like Transferases Superfamily Glycosyltran sferases Cluster411 2638 Glutaredoxi n-related protein DUF496 superfamily Cluster359 1848 Protein of unknown function DUF496 (Putative alpha helix protein) SprT-like family Cluster – Protein of unknown function DUF559 Cluster410 4308 FADlinked oxidase, Cterminal SprT TC 2.C. Electrochemi cal Potentialdriven transporters Ion-gradientdriven energizers Zinc-binding Cluster407 133019 Superfamily (Protein sprT) 251 P45097 Predicted organic radical activating enzyme like domain family 7-cyano-7deazaguanin e synthase like domain family Radical SAM enzymes superfamily Family not named Fer4_14 family (Radical SAM proteins) N-type ATP pyrophosphatase s family No result QueC family No result No result No result Cluster – 148455 Radical_SA Iron-binding M Superfamily (Radical activating enzyme) 252 P44124 253 P44125 No result 254 P45103 255 P45104 tRNA YrdC-like family SUA5 family threonylcarb amoyladeno sine biosynthesis -like domain family 30S Pseudouridine RIbosomal ribosomal synthase large subunit Sua5_yciO_yrd C family S4 family Cluster – 147255 AANH_like EC 2.7.-.-: Superfamily Transferases (PP-loop Transferring superfamily PhosphorusATPase) Containing Groups Cluster – No result No result 19329 (Hypothetic al protein ) Cluster – Sua5_yciO_ Metal145750 yrdC binding Superfamily (SUA5/yci O/yrdC family protein) Cluster – PseudoU_sy RNA141200 nth binding 5447 Protein of unknown function DUF335, SprT Cluster414 5506 Radical SAM Cluster384 3800 Exoenzyme S synthesis protein B/queuosin e synthesis Cluster398 4753 Pasteurellal es Cluster391 3974 Sua5/YciO/ YrdC/Ywl C Cluster415 2309 256 257 P44126 P44127 protein S4 like domain family RsuA/RluD family pseudouridin e synthase b family No result SMR domainlike superfamily No result No result No result No result Superfamily Proteins Smr family DUF412 family (Ribosomal large subunit pseudouridi ne synthase B) Cluster – Smr Nuclear 147429 Superfamily Receptors (Smr domain protein) Cluster – 156191 DUF412 Transmembr Superfamily ane (yfbV protein) 258 259 P71373 P44129 Putative uncharacteri zed protein like domain family Tyrosinedependent oxidoreductases family Sugar nucleotide epimerase related family Epimerase family No result No result No result TctB family Cluster – 146743 (Celldivision inhibitor) Cluster – 156295 (yciS protein) NADB_Ros EC 2.7.-.-: smann Transferases Superfamily Transferring PhosphorusContaining Groups DUF1049 Transmembr Superfamily ane Pseudouridi ne synthase, RsuA and RluB/E/F Cluster381 3237 Smr protein/Mut S2 Cterminal Cluster393 5154 Uncharacte rised protein family UPF0208 Cluster394 7300 NAD(P)binding Rossmannlike Domain Cluster407 7230 Protein of unknown function DUF1049 260 P44131 No result No result No result DUF945 family Cluster – 152146 (GTPbinding protein) 261 262 263 264 P44132 P45122 P44133 P44134 No result No result No result No result No result No result No result CAC2185-like family No result Connexin43 family Inner membrane protein family UPF0126 family No result No result No result Cluster – 152146 (Putative GTPbinding protein) Cluster – 133357 COG5339 EC 5.3.-.-: Superfamily Isomerases Intramolecul ar Oxidoreduct ases COG5339 EC 2.7.-.-: Superfamily Transferases Transferring PhosphorusContaining Groups UPF0126 Transmembr superfamily ane (Transmem brane protein) PrpR_N family Cluster – 148284 No result Transmembr ane (Sterol Oacyltransfer ase 1) Cluster – DUF1919 Metal129426 Superfamily binding (Capsular polysacchar ide Cluster398 6091 Protein of unknown function DUF945, bacterial Cluster398 6091 Protein of unknown function DUF945, bacterial Cluster413 7444 Uncharacte rised protein family UPF0126 Cluster415 4441 Gammaprot eobacteria Cluster411 8479 Protein of unknown function DUF1919 265 266 P44135 P44136 Phosphogly Arylsulfatase cerol family transferase I -like domain family Arylsulfatase family No result No result No result Sulfatase family biosynthesi s protein) Cluster – 151985 Sulfatase Transmembr Superfamily ane (sulphatase ) NicO family Cluster – 127674 NicO NickelSuperfamily binding (ShiF protein) 267 P44137 No result No result No result DUF1007 family Cluster – 156273 DUF1007 Zinc-binding Superfamily (exported protein) 268 P44138 No result RelE-like superfamily No result Plasmid_killer family Cluster – 156274 Plasmid_kil Zinc-binding ler Superfamily (Killer protein) 269 P44139 No result No result No result SirB family Cluster – 155547 (Protein sirB2) SirB Transmembr Superfamily ane Cluster413 3052 Membrane sulfatase, HI1246related Cluster404 1182 Nickel/cob alt transporter, highaffinity Cluster383 5140 Protein of unknown function DUF1007 Cluster405 6984 Plasmid maintenanc e system killer Cluster425 2806 Invasion gene expression up- 270 271 272 273 274 P44140 Same as 270 Same as 270 P44144 P44145 tRNA(Met) cytidine acetyltransf erase TmcA -like domain family/ Mycothiol acetyltransf erase -like domain 1/2/3 family - Acyl-CoA Nacyltransferases (Nat) superfamily/ NGNAT_acetyltr_ acetyltransfer 2 family ase 10 family Cluster – 113588 (Acetyltran sferase) P-loop containing nucleoside triphosphate hydrolases superfamily Helicase_R All DNAecD binding Superfamily /tRNA_bind _2 Superfamily regulator, SirB Cluster415 9674 Protein of unknown function DUF699, ATPase putative - - - - - - - - - - - - - - - No result No result No result YcaO-like family Cluster – 156283 YcaO No result Superfamily No result Glucos_trans_II family (YcaO protein) Cluster – 85251 No result Cluster410 2994 Integral to membrane No result Sigma3 and sigma4 domains of RNA polymerase sigma factors superfamily No result (4hydroxyben zoate octaprenylt ranferase related protein) Transmembr ane 275 276 277 278 279 No result P44148 P44150 P45138 P44154 No result AT4G25080 protein -like domain ½ family Ribosome maturation factor rimP -like domain family No result No result S-adenosyl-Lmethioninedependent methyltransferas es superfamily YhbC-like, Nterminal domain family No result No result Methyltransf erase family No result No result No result Methyltransf_18 family DUF150 family Zn_Tnp_IS1595 Cluster – 141467 (Iron ABC transporter, solutebinding protein) Cluster – 146961 No result No result AdoMet_M All DNATases binding Superfamily (Methyltran sferase) Cluster – Sm_like Iron-binding 149464 Superfamily (YhbC protein ) (protein associated with RNA) Cluster – 156282 DUF2310 Zinc-binding Superfamily (Zn-ribboncontaining protein) 280 P44156 Cysteine desulfuratio n protein sufE -like SufE/NifU superfamily BOLA-like proteinrelated family SufE family Cluster – 142307 (SufE SufE Nuclear Superfamily Receptors No result Cluster408 0031 Methyltran sferase type 11 Cluster418 9503 Uncharacte rised protein family UPF0090 Cluster377 1672 Uncharacte rised conserved protein UCP02903 7 Cluster360 5417 Fe-S metabolism 281 282 283 P45145 P45146 Q57320 domain family No result No result No result protein) No result Indoleamine 2,3dioxygenase-like family ABC transporter transmembrane region family No result LrgA family Putative serotonin transporter family LrgB-like family No result LysE family Cluster – 151186 LrgA Transmembr Superfamily ane (Murein hydrolase exporter) Cluster – 151187 LrgB Transmembr Superfamily ane (Negative regulator of murein hydrolase) Cluster – 152577 Cluster413 9093 LrgB-like protein LysE Transmembr Superfamily ane Cluster418 4271 Lysine exporter protein (LYSE/YG GA) Cluster408 7288 2Fe-2S ferredoxinlike (Threonine efflux protein) 284 285 P45154 P44158 NADHquinone oxidoreduct ase -like domain family No result 2Fe-2S ferredoxin-like family Family not named Fer2 family Cluster – 145548 fer2 Iron-binding Superfamily (Ferredoxin ) No result No result Pox_A8 family associated SufE Cluster 4142464 LrgA Cluster – 119769 (endospore developme No result Transmembr ane Cluster325 9605 Proteobacte ria 286 287 288 P71375 P44160 P44161 No result Aldose 1epimerase family protein -like domain family No result No result Galactose mutarotase-like superfamily No result Sodium/solut e symporter family nt protein) Sodium:solute Cluster – symporter family 141147 Aposporyassociated protein crelated family Aldose_epim family No result MatP family (Na+/gluco se cotransport er) Cluster – 112182 SLC5-6Transmembr like_sbd ane Superfamily Cluster427 9952 Sodium/sol ute symporter Aldose_epi No result m Superfamily Cluster415 8146 Aldose 1epimerase MatP Zinc-binding Superfamily Cluster361 8064 Protein of unknown function DUF1047 Cluster418 6044 Protein kinase-like (kinase like protein) Cluster – 135338 (Dehydroge nase) 289 290 291 P44162 P44163 P71376 No result No result CRS2- Protein kinaselike (PK-like) superfamily No result YhbY-like No result No result No result RIO1 family LPAM_1 family CRS1_YhbY Cluster – 147713 (Aminogly coside phosphotra nsferase) Cluster – 19499 PKc_like All lipidSuperfamily binding proteins No result (Hypothetic al protein) Cluster – CRS1_Yhb No result rRNA- Cluster662 407 Haemophil us influenzae Cluster415 292 293 294 P44164 P71378 P44165 associated factor 1, chloroplasti c -like domain ½ family Serine/threo nine-protein phosphatase Pgam5, like domain family family No result Apolipoprotein A-I superfamily 149377 Y binding Superfamily Proteins (RNAbinding protein) Phosphoglycerat e mutase-like superfamily NADPHOuter membrane dependent efflux proteins 7-cyano-7(OEP) family deazaguanin e reductase like domain ½ family/ Outer membrane protein oprJ -like domain family His_Phos_1 family Cluster – 147721 Late embryogenes is abundant (plants) learelated family Lipase_bact_N family (Phosphohi stidine phosphatas e sixA) Cluster – 141357 Outer membrane cation efflux protein family QueF_N family No result (Late embryogen esis abundant protein 1) Cluster – 147254 (Outer membrane efflux protein) HP EC 3.1.-.-: Superfamily Hydrolases Acting on Ester Bonds No result Outer membrane TFold Outer Superfamily membrane 9250 RNAbinding, CRM domain, prokaryote Cluster415 8723 Phosphohis tidine phosphatas e activity Cluster Cluster352 1305 Outer membrane efflux protein 295 296 297 298 299 P71379 P45173 P44167 P44168 P45180 family Cysteine Cystathionine desulfurase synthase-like -like domain family family Glycogen synthase like domain ½ family Aminotran_5 family Cluster – 139955 Bacterioferrit Ferritin family in family (Cysteine desulfurase ) Cluster – 147577 S-adenosyl-Lmethioninedependent methyltransferas es superfamily Methyltransf erase family (bacteriofer ritin) Cluster – 143210 No result No result Ferritin -like Ferritin-like domain superfamily family tRNA (mo5U34)methyltransf erase -like domain family No result Cysteine desulfurylase family Oligosaccharide phosphorylase family Methyltransf_9 family AAT_I EC 4.1.-.-: Superfamily Lyases CarbonCarbon Lyases Cluster412 0088 Cysteine desulfurase Ferritin_like All lipidSuperfamily binding proteins Cluster417 4904 DNAbinding protein Dps Cluster390 4934 TRNA (mo5U34)methyltrans ferase Cluster433 2397 Uncharacte rised conserved protein UCP00617 3 Cluster397 6983 Glycogen/s tarch/alphaglucan phosphoryl ase AdoMet_M Zinc-binding Tases Superfamily (Methyltran sferase) Glycogen phosphorylas e family CxxCxxCCfamil y Cluster – 156293 (Putative zincor iron-chelating domain) (ycgN protein) Phosphorylasefa mily Cluster – 147282 (Glycogen phosphoryl ase 1) FliB All lipidSuperfamily binding (Flagellin proteins Nmethylase) Glycosyltra nsferase_G TB_type Superfamily EC 2.4.-.-: Transferases Glycosyltran sferases 300 301 302 303 304 P45182 P44169 P44170 P44171 O86237 Vitamin B12 transporter BtuB -like domain family No result No result No result Macrophage migration inhibitory factor -like domain family Ligand-gated protein channel family (Porins superfamily) No result Frataxin-like family No result Tautomerase/MI F superfamily Cluster – 149214 OM_channe ls Superfamily No result (Oar protein) Multidrug No result resistance efflux transporter EmrE family No result Plug family No result No result HSDR_N_2fami ly (Type I restriction enzyme R protein N terminus) EamA-like transporter family Cluster – 137251 (Adenylate cyclase) Cluster – 143726 HSDR_N EC 3.1.-.-: Superfamily Hydrolases Acting on Ester Bonds No result Transmembr ane Cluster400 8610 Protein of unknown function DUF6, transmembr ane No result All lipidbinding proteins Cluster332 978 Haemophil us influenzae Cluster401 6578 Macrophag e Migration Inhibitory Factor Transcription factor DP family (Permease of the drug/metab olite transporter (DMT) Cluster – 19520 Tautomerase_2 family (Hypothetic al protein ) Cluster – No result 156324 (4oxalocroton ate Cluster425 8564 TonBdependent receptor, plug Cluster410 6033 Complete proteome EC 3.1.-.-: Hydrolases Acting on Ester Bonds 305 306 P44172 P44173 Activating signal cointegrator 1 -like domain family yqfB-like famiy No result ABC transporter ATPase domainlike family No result ASCH family tautomeras e) Cluster – 151905 (Tex protein) No result Zeta_toxin family Cluster – 145346 (kinase) 307 308 P44175 P44176 No result No result Error-prone PHP domain DNA family polymerase -like domain family No result PHP domain protein family No result PHP domain family Cluster – 108913 ASCH EC 3.6.-.-: Superfamily Hydrolases Acting on Acid Anhydrides COG4185 EC 3.5.-.-: Superfamily Hydrolases Acting on CarbonNitrogen Bonds, other than Peptide Bonds No result Transmembr ane (Putative peptidoglyc an bound protein) Cluster – PHP Zinc-binding 147364 Superfamily (polymerase (Protein and trpH) Histidinol Phosphatase domain) Cluster377 5188 Uncharacte rised conserved protein UCP02914 3 Cluster394 0252 Bacteria Cluster429 9950 Proteobacte ria Cluster413 2555 Polymerase and histidinol phosphatas e, Nterminal 309 P44177 No result No result No result 310 P44180 No result No result No result 311 P44181 No result "Winged helix" DNA-binding domain superfamily No result No result No result 312 313 P44183 P45197 No result No result No result No result RelB antitoxin family Cluster – 133463 Structural protein (Matrix (Hypothetic protein,Core al protein) protein,Viral occlusion body,Keratin ) Ezrin/radixin/mo Cluster – DUF2213 EC 2.7.-.-: esin family 133464 Superfamily Transferases (Putative Transferring bacteriopha Phosphorusge protein) Containing Groups HTH_20family Cluster – 114345 (Putative ArsR-like transcriptio nal regulato) DUF1073 family Cluster – 128920 Phage_pRha family (Putative bacteriopha ge protein) Cluster – 130171 No result DUF2513 EC 4.2.-.-: Superfamily Lyases CarbonOxygen Lyases phge_rel_H Outer I1409 membrane Superfamily hage_pRha EC 2.7.-.-: Superfamily Transferases - Cluster402 7900 Proteobacte ria Cluster400 8185 Uncharacte rised conserved protein UCP02921 5 Cluster415 0082 Bacteria Cluster380 4492 Phagerelated protein HI1409 Cluster424 2382 Phage (Prophage protein ) 314 315 316 317 P44185 P44186 P44187 P44188 No result No result No result No result Endochitina se -like domain family Lysozyme-like superfamily No result No result No result No result Chitinaserelated family No result HAMP family Glyco_hydro_19 family Cluster – 112330 (Mannosyl transferase) Cluster – 95125 (Sec1 protein) Cluster – 139238 No result Transferring PhosphorusContaining Groups All lipidbinding proteins DUF2570 Transmembr Superfamily ane lysozyme_li All lipidke binding Superfamily proteins (prophage chitinase) No result Phage_holin_3 family 318 P44189 No result No result No result Bro-N family 319 P44190 No result No result No result Gp49 family Cluster – 152656 Phage_holin TC 1.E. _3 Channels/Po Superfamily res - Holins (Holin (Lysis protein 13)) Cluster – Bro-N 146013 Superfamily /P22_AR_C (Antirepres Superfamily sor protein) Cluster – Gp49 152258 Superfamily regulatory protein, Rha Cluster394 8635 Pasteurella ceae Cluster370 0737 Haemophil us influenzae Cluster395 4912 Glycoside hydrolase, family 19, catalytic Cluster396 9424 Holin, phage lambda Transmembr ane Cluster408 1061 BRO, Nterminal EC 3.1.-.-: Hydrolases - Cluster415 7329 (prophage protein) 320 P44191 DNAbinding protein -like domain family lambda repressor-like DNA-binding domains superfamily No result HTH_3 family 321 P44193 No result No result No result AntA family 322 P44194 No result DHS-like NAD/FADbinding domain superfamily No result HTH_23 family 323 P44196 No result No result No result Xol-1_N family (ribosomal protein S5 domain 2-like) 324 P45202 Prolyl- YbaK/ProRS Uncharacteri tRNA_edit Cluster – 152259 (DNAbinding prophage protein) Cluster – 24522 Acting on Ester Bonds COG3636 All DNASuperfamily binding AntA Iron-binding Superfamily / (Hypothetic P22_AR_C alprotein) Superfamily Cluster – No result rRNA136774 binding Proteins (DNA binding protein) Cluster – No result All lipid120248 binding proteins (Putative periplasmic binding protein CbiK precursor) Cluster – YbaK_like EC 3.4.-.-: Addiction module killer protein, HI1419 Cluster410 8294 Addiction module antidote protein, HI1420 Cluster412 9441 AntA/AntB antirepress or Cluster414 7257 Proteobacte ria Cluster412 3296 Proteobacte ria Cluster394 325 326 327 328 P56507 P44197 Q57152 P44198 tRNA synthetase like domain family associated domain family zed family family No result Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains family Pseudouridine synthase RsuA/RluD family No result Rsbr_N family RNA pseudouridyl ate synthase family protein PseudoU_synth_ 2 family YqcC-like family No result DUF446 family (tRNA pseudouridine synthase C) Cluster – 111794 YcgL family Cluster – 92219 No result tRNA pseudouridi ne synthase C -like domain family No result YcgL-like 146267 Superfamily Hydrolases Acting on (Transcripti peptide onal bonds regulator (Peptidases) ybaK) Cluster – UPF0181 All DNA34950 Superfamily binding (Major capsid protein) No result Cluster – 126634 PseudoU_sy No result nth Superfamily (Pseudouri dylate synthase) DUF446 No result Superfamily (yqcC protein) (Transcripti onal regulator) YcgL Outer Superfamily membrane 7534 Conserved hypothetica l protein CHP00011 Cluster463 8118 Uncharacte rised protein family UPF0181 Cluster402 6323 Pseudouridi ne synthase, RsuA and RluB/C/D/ E/F Cluster405 8700 Protein of unknown function DUF446 Cluster408 3593 YcgL domain 329 P44201 No result No result No result DUF340 family Cluster – 147632 DUF340 Transmembr Superfamily ane No result All lipidbinding proteins - (Efflux system protein) -- - - Cluster408 2786 Protein of unknown function DUF340, prokaryotic membrane Cluster406 3148 Cytochrom ec assembly protein, transmembr ane region Cluster415 1583 Uncharacte rised conserved protein UCP01233 5 Cluster352 1305 Outer membrane efflux protein - - - - - - (Permease protein of ABC transporter) 330 331 P44202 P44203 No result No result No result No result Family not named No result DsbD family Cluster – 140799 (Cytochro me c-type biogenesis protein ccdA) DUF2846 family Cluster – 133467 DsbD Transmembr Superfamily ane DUF2846 Transmembr Superfamily ane (lipoprotein ) 332 333 334 P45217 Same as 293 Same as Outer Outer membrane membrane efflux proteins protein oprJ (OEP) family -like domain family Outer membrane cation efflux protein family OEP family - - - - - - Cluster – 147254 335 336 337 338 292 P44205 Q57380 P44208 P44209 Maltose/mal todextrinbinding protein -like domain family Periplasmic binding proteinlike II superfamily Molybdatebinding periplasmic protein family Sulfate transport system permease protein -like domain family MetI-like family Molybdenum BPD_transp_1 transport family system permease protein MODB family Transposase Recombinase -like domain DNA-binding family domain family No result Hypothetical protein HI1480 family No result No result SBP_bac_11 family HTH_Tnp_Mu_ 2 family No result Cluster – 148792 (Molybdate ABC transporter, periplasmic -binding protein) Cluster – 106173 SBP_bac_1 EC 3.1.-.-: Superfamily Hydrolases Acting on Ester Bonds Cluster392 0215 Molybdenu m ABC transporter, periplasmic binding protein TM_PBP2 Transmembr Superfamily ane Cluster411 1433 Bindingproteindependent transport systems inner membrane component Cluster450 1988 Mu DNA binding, I gamma subdomain (ABC transporter, permease protein) Cluster – 147020 (Mu-like prophage FluMu transposase A) Cluster – 64926 (DNA for 5S rRNA HTH_Tnp_ RNAMu_2 binding Superfamily Proteins No result All DNAbinding Cluster651 846 1MW5 339 340 P44210 P44212 No result No result No result MIT domain family No result No result No result TPR_11 family (Fragment) ) Cluster – 136630 (Transmem brane receptor Roundabou t1) Cluster – 19581 No result Zinc-binding Cluster459 0269 Proteobacte ria No result No result No result Nickelbinding Cluster400 2200 Bacterioph age Mu Gam like Cluster437 2814 Pasteurellal es No result Outer membrane Cluster468 7471 Bacteria All lipidbinding proteins Cluster374 6515 Proteobacte ria (Mu like) 341 342 343 P44213 P44214 P44215 No result No result No result No result No result Bacterial exopeptidase dimerisation domain family No result No result No result FlaC_arch family (Flagella accessory protein C) No result No result Cluster – 19581 (Mu like) Cluster – 141573 (Membrane associated lipoprotein) Cluster – No result 136913 (Golgi complexassociated protein) 344 345 346 P44217 P44218 P44219 No result No result No result No result No result NacetylmuramoylL-alanine amidase-like No result No result No result HMG_box family No result Cluster – 143933 No result All lipidbinding proteins (ABC-type oligopeptid e transport system, periplasmic component) Cluster – PGRP Metal112438 Superfamily binding (Nacetylmura moyl-Lalanine amidase) DUF2644 family Cluster – 19593 DUF2644 superfamily TC 1.E. Channels/Po res - Holins (Hypothetic al protein) 347 P44220 No result No result No result SHR3_chaperon e family (ER membrane protein SH3) 348 P44221 No result Glucocorticoid receptor-like (DNA-binding domain) No result zf-dskA_traR family Cluster – 19594 DUF2681 EC 3.6.-.-: Superfamily Hydrolases Acting on (Hypothetic Acid al protein) Anhydrides Cluster – zfZinc-binding 151030 dskA_traR Superfamily (DnaK Cluster383 3866 Gammaprot eobacteria Cluster528 019 Haemophil us influenzae Cluster394 1109 Uncharacte rised protein family HI1495 Cluster390 3620 Haemophil us influenzae Cluster436 5291 Zinc finger, C4 superfamily 349 350 351 352 353 P44222 O86242 P44223 P44224 P44225 No result No result No result No result No result No result No result "Winged helix" DNA-binding domain superfamily No result No result No result No result No result No result No result deletion suppressor protein) DUF2730 family Cluster – 126210 HTH_12 family (Sensor histidine kinase) Cluster – 133279 (DNAbinding domain) DUF3486 family Cluster – 133128 Terminase_6 family DUF935 family (Mu-like prophage FluMu protein gp27) Cluster – 133130 (Mu-like prophage FluMu protein gp28) Cluster – 155792 DksA/TraR -type DUF2730 All lipidSuperfamily binding proteins Cluster414 1003 Gammaprot eobacteria HTH_12 Zinc-binding Superfamily Cluster418 4246 Proteobacte ria No result Cluster408 4663 Proteobacte ria RNAbinding Proteins COG4373 All lipidSuperfamily binding (Mu-like proteins prophage FluMu protein gp28) DUF935 Zinc-binding Superfamily Cluster378 8315 Uncharacte rised conserved protein UCP00705 6 Cluster415 1326 354 P44226 No result No result No result Phage_Mu_F family (Mu-like prophage FluMu protein gp29) Cluster – 155625 Protein of unknown function DUF935 Phage_Mu_ All lipidF binding Superfamily proteins (Head morphogen esis protein) 355 356 357 358 P44227 P44228 Same as 356 P44230 No result No result No result No result YqbF N-terminal No result domain-like family Mu-like_gpT family HeH family Cluster – 133198 Cluster411 8925 Phage putative head morphogen esis protein, SPP1 gp7 Cluster405 3807 Bacteria (Major head subunit (gpT)) Cluster – 155801 MuEC 2.7.-.-: like_gpT Transferases Superfamily Transferring PhosphorusContaining Groups LEM_like Outer Superfamily membrane (Mu-like prophage FluMu protein gp35) - - - - DUF1320 EC 2.4.-.-: Cluster414 - - - - No result No result No result DUF1320 family Cluster – Cluster394 7763 2OUT 155802 359 360 361 362 P44231 P44232 P44234 P44235 No result No result No result No result No result No result No result No result No result No result No result No result Superfamily Transferases Glycosyltran sferases 1019 Protein of unknown function DUF1320 DUF1834 Zinc-binding Superfamily (Mu-like prophage FluMu protein gp37) Cluster – 133134 Cluster372 1770 Protein of unknown function DUF1834 DUF2635 Outer Superfamily membrane (Mu-like prophage FluMu protein gp38) Cluster – 155921 Cluster412 7856 Proteobacte ria Tail_tube Zinc-binding Superfamily (Tail tube protein (gpM)) Cluster – 155808 Cluster409 7488 Proteobacte ria COG4518 All DNASuperfamily binding Cluster395 2333 Gammaprot eobacteria (Mu-like prophage FluMu protein gp36) DUF1834 family Cluster – 155803 PTS_IIA family Tail_tube family FluMu_gp41fam ily (Mu-like 363 P44238 No result No result No result Phage_Mu_Gp4 5 family prophage FluMu protein gp41) Cluster – 155809 Phage_Mu_ Transmembr Gp45 ane Superfamily (Bacterioph age (Baseplate assembly) protein) Cluster – GP46 EC 2.7.-.-: 155812 Superfamily Transferases (Protein Transferring gp46) PhosphorusContaining Groups Cluster – Baseplate_J All lipid155814 Superfamily binding proteins (Protein gp47) 364 P44239 No result No result No result GP46 family 365 P44240 No result No result No result Baseplate_J family 366 P44241 No result No result No result DUF2313 family Cluster – 155819 (Mu-like prophage FluMu protein DUF2313 All lipidSuperfamily binding proteins Cluster409 8758 Mu-like prophage protein gp45 Cluster410 7343 Phage GP46 Cluster396 1356 Baseplate assembly protein Jlike, predicted Cluster396 7784 Gammaprot eobacteria 367 368 369 370 P44242 P71390 P44243 P44246 No result No result Pectin lyase-like superfamily No result No result No result eRF1 methyltransf erase catalytic subunit MTQ2 -like domain family S-adenosyl-Lmethioninedependent methyltransferas es superfamily No result tRNA 5methylamin omethyl-2thiouridine like domain family FAD/NAD(P)binding domain superfamily FAD NAD binding oxidoreducta ses family No result Mu-like_Com family gp48) Cluster – 100889 (Mu-like prophage FluMu defective tail fiber protein) Cluster – 133104 (Cryptic Mu-phage protein Com) MethyltransfD12 Cluster – family 133481 No result Cluster – 150558 Cluster405 2667 Pectin lyase fold/virulen ce factor MuNo Result like_Com Superfamily Cluster475 5074 Bacteria No result Cluster363 8648 D12 class N6 adeninespecific DNA methyltrans ferase Cluster414 6363 TRNA U34 5methylamin omethyl-2thiouridine (Hypothetic al protein ) Methyltransf_30 family EC 4.2.-.-: Lyases CarbonOxygen Lyases Methyltrans f_30 Superfamily (FAD /Strep_67k dependent Da_ant oxidoreduct Superfamily ase) EC 3.1.-.-: Hydrolases Acting on Ester Bonds EC 1.3.-.-: Oxidoreduct ases - Acting on the CHCH group of donors 371 372 373 374 Same as 370 P44247 P45244 P44251 - - - - - - - No result FAD/NADlinked reductases, Nterminal and central domains FAD NAD binding oxidoreducta ses family DAO family (FAD dependent oxidoreductase) Cluster – 150558 No result EC 2.4.-.-: Transferases Glycosyltran sferases FMN-dependent nitroreductaselike superfamily NADPH nitroreductas e family Nitroreductase family Oxygeninsensitive NAD(P)H nitroreducta se -like domain family No result (FAD dependent oxidoreduct ase) Cluster – 143710 (Nitroreduc tase family protein) alpha/betaHydrolases superfamily No result DUF452 family Cluster – 135245 Nitro_FMN EC 2.3.-.-: _reductase Transferases Superfamily Acyltransfer ases DUF452 All lipidSuperfamily binding proteins (Hypothetic al protein) 375 P44252 No result No result Lipoproteinreleasing system MacB_PCDfami ly Cluster – 141137 MacB_PCD TC 3.A. Superfamily Primary /FtsX Active biosynthesi s protein MnmC, Cterminal Cluster414 6363 TRNA U34 5methylamin omethyl-2thiouridine biosynthesi s protein MnmC, Cterminal Cluster415 7972 Nitroreduct ase-like Cluster398 0451 Protein of unknown function DUF452 Cluster416 3048 Lipoprotein transmembra ne protein lole family 376 P45252 Superkiller protein 3 like domain family 377 P45253 Release N5-glutamine factor methyltransferas glutamine e, HemK family methyltransf erase -like domain family HEMK methyltransf erase family member 378 P44253 No result No result 379 P44254 No result Tetratricopeptide Family not repeat (TPR) named family No result No result No result (Lipoprotei Superfamily Transporters n releasing - P-P-bondsystem hydrolysistransmembr driven ane protein transporters LOLE) Transglut_core2f Cluster – Transglut_c EC 2.4.-.-: amily 141615 ore2 Transferases Superfamily (TPR Glycosyltran domain sferases protein) Methyltransf_31 Cluster – AdoMet_M EC 2.1.-.-: family 145158 Tases Transferases Superfamily (Ribosomal Transferring RNA small One-Carbon subunit Groups methyltrans ferase C (EC 2.1.1.52) RDD family Cluster – RDD Transmembr 123426 Superfamily ane No result (Putative integral membrane protein) Cluster – 83894 (Protein No result All DNAbinding releasing system, transmembr ane protein, LolC/E family Cluster388 0357 Gammaprot eo bacteria Cluster415 1922 Modificatio n methylase HemK Cluster365 1740 RDD Cluster406 0045 Haemophil us HI1562) 380 381 382 383 P44255 P44256 P44260 Q4QKT3 No result DNA polymerase IV -like domain family No result No result No result Lesion bypass DNA polymerase (Yfamily), little finger domain superfamily No result No result No result No result DUF462 family UPF0242 family Cluster – 156356 (Putative transportin g ATPase) Cluster – 14066 DUF462 CopperSuperfamily binding No result Nickelbinding (Serine Threonine Protein Phosphatas e 5, Tetratricop eptide repeat) Cluster479 1876 Protein of unknown function DUF462 No result (no result ) No result No result DUF935family Band_7_1family Cluster – 155792 (Mu-like prophage FluMu protein gp29) Cluster – 155914 (Replicatio n protein) DUF935 MetalSuperfamily binding Cluster388 4590 Protein of unknown function DUF935 No result Cluster383 7166 Replication endonuclea se, rRNAbinding Proteins 384 385 P44262 386 Same as 384 P45267 387 P44267 388 389 P44268 P44269 4hydroxyphe nylpyruvate dioxygenase -like domain ½ family - Glyoxalase/Bleo No result mycin resistance protein/Dihydrox ybiphenyl dioxygenase superfamily - Adenylate CYTH-like cyclase -like phosphatases domain superfamily family No result No result No result No result UPF0276 protein MCA3108 like domain family Xylose isomerase-like superfamily No result No result No result YecMfamily Cluster – 156340 Glo_EDI_B No result RP_like Superfamily (Protein yecM) - - CYTH family Cluster – (CyaB-like 148636 adenlyl cyclases) (ygiF protein) DUF2063 family Cluster – 156353 DUF692 family - - CYTHAll DNAlike_Pase binding Superfamily DUF2063 Zinc-binding Superfamily (Hypothetic al protein) Cluster – DUF692 Manganese133486 Superfamily binding (Hypothetic al protein) No result Cytomega_UL2 0A family Cluster – 148891 (Putative COG3767 Iron-binding Superfamily probable, phage Cluster401 1886 Protein of unknown function DUF991 Cluster269 1408 CAMP biosyntheti c process Cluster345 1596 Pasteurellal es Cluster412 93114 Protein of unknown function DUF692 (Xylose isomeraselike) Cluster410 3162 Complete proteome 390 391 P44270 P44272 No result No result Aquaporin-like family No result No result No result DoxX family SH3_3 family periplasmic protein) Cluster – 149079 DoxX Transmembr Superfamily ane Cluster391 9138 DoxX (Putative integral membrane protein) Cluster – 130233 SH3_3 Transmembr Superfamily ane Cluster408 9004 Uncharacte rised conserved protein UCP00615 8, SH3, YgiM Cluster385 9326 Integral to membrane (SH3 domain protein) 392 393 P44275 P44277 No result LRP2binding protein -like domain ½ family No result HCP-like superfamily No result SEL-1-like protein family No result Sel1 family Cluster – 120247 (Putative cytoplasmi c membrane protein CbiL precursor) Cluster – 139872 (Sel-1-like protein) No result Transmembr ane Sel1 All lipidSuperfamily binding proteins Cluster421 5175 Keyword 9172 (Serine 394 395 396 397 P44278 P71394 P45279 P45280 No result No result No result YwiC family Cluster – 156361 (Ywic protein) Cluster – 141938 RutC family YjgF-like protein yjgF superfamily -like domain famiy Translation initiation inhibitor family Ribonuc_L-PSP family No result No result Phosphate transporter family (PHO4 family ) Cluster – 133501 SNARE_assoc family Cluster – 142554 No result Gam-like family No result Inner membrane protein dedarelated family (Translatio n initiation inhibitor) YwiC Transmembr Superfamily ane YjgF_YER 057c_UK11 4_family Superfamily EC 2.5.-.-: Transferases Transferring Alkyl or Aryl Groups, Other than Methyl Groups DUF1043 Transmembr Superfamily ane (YhcB protein) (DedAfamily SNARE_ass Transmembr oc ane Superfamily Threonine Protein Phosphatas e 5, Tetratricop eptide repeat) Cluster411 8246 Bacteria Cluster405 4994 Keyword 10030 (Endoribon uclease LPSP/choris mate mutaselike) Cluster410 7460 Protein of unknown function DUF1043 Cluster397 1317 SNARE associated Golgi 398 P44279 No result No result No result CLPTM1family (Cleft lip and palate transmembrane protein 1 ) Aspartate AA family kinase family (Amino acid kinase family) 399 Q57525 Aspartokina se -like domain family Carbamate kinase-like superfamily 400 P44280 No result P-loop containing nucleoside triphosphate hydrolases superfamily No result Ribokinase-like superfamily Inner membrane protein yeihrelated family Cons_hypoth698 family No result EcoR124_C family 401 402 P45290 P44281 No result No result No result DUF463 family integral membrane protein) Cluster – 113288 (DNA helicase) Cluster – 146114 protein DUF2726 EC 3.1.-.-: Superfamily Hydrolases Acting on Ester Bonds AAK Superfamily /ACT (Aspartokin Superfamily ase (EC 2.7.2.4) (Aspartate kinase)) Cluster – DUF463 156298 Superfamily EC 2.4.-.-: Transferases Glycosyltran sferases Cluster385 8451 Aspartate kinase activity Zinc-binding Cluster415 3076 Protein of unknown function DUF463, YcjX-like protein Cluster416 5087 Uncharacte rised protein family UPF0324 Cluster414 9146 (Putative ATPase) Cluster – 156575 Cons_hypot Transmembr h698 ane Superfamily (Membrane protein Yeih) Cluster – 133000 No result Cluster398 7398 Alphaprote obacteria No result (Class III chitinase) 403 404 405 406 407 P44282 No result P45298 P45300 P52606 Chemotaxis protein CheA -like domain family Histidinecontaining phosphotransfer domain, HPT domain superfamily No result No result Ribosomal Tetrapyrrole RNA small methylase family subunit methyltransf erase I -like domain family Sadenosylmet hioninedependent methytransfe rase subfamily TP_methylase family UPF0102 protein MCA0184 like domain family Restriction endonucleaselike superfamily No result UPF0102 family Glucose-6- mono-SIS Cluster – 101158 (Sensor histidine kinaserelated protein) Cluster – 144435 HPT Zinc-binding Superfamily TP_methyla se Superfamily (Tetrapyrro le methylase family protein) Sedoheptulos SIS_2 family Cluster – 155972 (Endonucle ase (EC 3.1.-.-)) Cluster – EC 2.7.-.-: Transferases Transferring PhosphorusContaining Groups UPF0102 All lipidSuperfamily binding proteins SIS Manganese- Restriction endonuclea se, type I, EcoRI, R subunit Cluster439 7702 Fungi Cluster416 2143 Uncharacte rised protein family UPF0011 (Cobaltprecorrin-4 Transmethy lase; Domain 1) Cluster412 4296 (Restriction endonuclea se-like) Cluster388 408 409 410 P45301 Q57544 P45305 phosphate isomerase like domain ½ family domain family No result No result e 7phosphate isomerase / dnaa initiatorassociating factor for replication initiation family No result (Sugar ISomerase) 147050 Superfamily binding (Sugar (Phosphohe ISomerase) ptose isomerase (EC 5.-.-.-)) 7230 Interconver ting aldoses and ketoses, and related compounds BON family Cluster – 84123 BON All lipidSuperfamily binding proteins Cluster413 8967 Transportassociated Lactamase_ Iron-binding B Superfamily Cluster417 0543 Betalactamaselike Hydroxyacy lglutathione hydrolase like domain family Metallohydrolase/oxidor eductase superfamily Beta lactamase domain family Lactamase_Bfa mily Deoxyribon uclease TatD -like domain family TatD Mgdependent DNase-like family TATD family deoxyribonu clease TatD_DNasefam ily (Homolog of osmotically induced OSMY protein of E.coli) Cluster – 142344 (Metallobetalactamase superfamily protein) Cluster – metallo149137 dependent_ hydrolases (Deoxyribo Superfamily nuclease EC 3.1.-.-: Hydrolases Acting on Ester Bonds Cluster395 7754 Deoxyribon uclease, TatD Mg- 411 412 413 P44283 P44284 P44285 Sonic hedgehog protein -like domain ½ family Sonic hedgehog protein -like domain ½ family ErfK/YbiS/ YcfS/YnhG family protein -like No result No result Peptidase_M15_ 2family tatD) Cluster – 147735 Peptidase_ No result M15_3 Superfamily (Putative exported protein) Hedgehog/DDpeptidase superfamily No result Peptidase_M15_ 2family Cluster – 147735 (Putative exported protein) L,Dtranspeptidase catalytic domain-like No result YkuD family Cluster – 130284 (Peptidogly Peptidase_ EC 3.1.-.-: M15_3 Hydrolases Superfamily Acting on Ester Bonds YkuD Transmembr Superfamily ane dependent Cluster399 1562 Protein of unknown function DUF882, bacterial (Hedgehog/ DDpeptidase, zincbinding motif) Cluster399 1562 Protein of unknown function DUF882, bacterial (Hedgehog/ DDpeptidase, zincbinding motif) Cluster281 7677 YkuD domain 414 P44287 domain family No result family No result Uncharacteri zed family PqiA family can-binding protein) Cluster – PqiA Transmembr 133477 Superfamily ane (Paraquatinducible protein A) 415 416 417 418 P44288 P44289 P44290 P44292 No result No result No result Putative uncharacteri No result Uncharacteri zed family MCE family Cluster – 130652 (Paraquatinducible protein B) Cluster – 151054 MFS general substrate transporter superfamily PHydroxybenz oic acid efflux pump subunitrelated family FUSC-like inner membrane protein yccS family No result No result DUF2057 family Cluster – 126294 No result No result DUF218 family (Putative efflux (PET) family transporter) (Exopolyga lacturonase precursor) Cluster – 115958 MCE Transmembr Superfamily ane FUSC-like Superfamily / FUSC_2 Superfamily Cluster386 1391 Paraquatinducible protein A (Multihaem cytochrome ) Cluster397 3964 Mammalia n cell entry related TC 9.B. Incompletely Characterize d Transport Systems Putative uncharacteri zed transport proteins DUF2057 All lipidSuperfamily binding proteins Cluster415 8714 Protein of unknown function DUF893, YccS/YhfK YdcF-like Transmembr Superfamily ane Cluster397 0067 Cluster346 4715 Pasteurellal es zed protein like domain family 419 P45332 No result (Protein ydcF) No result No result YjgP_YjgQ family Cluster – 152692 (YjgP/Yjg Q protein) 420 421 422 P45333 P44293 P44294 No result Protein ygiW -like domain family No result No result Hypothetical protein YgiW family No result No result YjgP_YjgQ family BOF family Cluster – 152692 (YjgP/ YjgQ protein) Cluster – 156370 (Protein ygiW precursor) No result No result HgmA Family No result Protein of unknown function DUF218 COG0795 TC 2.A. Cluster427 Superfamily Electrochemi 1706 cal Potential- Predicted driven permease transporters - YjgP/YjgQ Porters (uniporters, symporters, antiporters) COG0795 Transmembr Cluster427 Superfamily ane 1706 Predicted permease YjgP/YjgQ BOF TC 3.A.5 Superfamily Type II (general) secretory pathway (IISP) family No result No result Cluster410 2476 Hypothetic al protein YgiW (OB fold (Dihydrolip oamide Acetyltrans ferase, E2P)) Cluster477 3061 (homogentisate 1,2-dioxygenase) 423 424 P44296 Q57066 Erythrocyte membrane protein 1, PfEMP1 like domain Adhesin YadA, collagen-binding domain family Transposase Homeodomain-like domain like superfamily family TSBP protein YadA_head (fragment) family Subfamily (Head domain of trimeric autotransporter adhesin) No result HTH_28family 425 P44297 No result No result No result UPF0231 family 426 O05087 No result No result Manganese transporter family Nramp family Cluster – 108737 (MapA protein (Hsf)) Cluster – 142986 (Putative transposase ) Cluster – 156244 No result EC 3.4.-.-: Hydrolases Acting on peptide bonds (Peptidases) HTH_23 All lipidSuperfamily binding proteins UPF0231 TC 1.C. Superfamily Channels/Po res - Pore(Pasteurella forming haemolytic toxins a putative (proteins and coproporph peptides) yrinogen III oxidase) Cluster – MntH TC 2.A. 149528 Superfamily Electrochemi cal Potential(Mn2+ and driven Fe2+ transporters transporter Porters of the (uniporters, Homogenti sate 1,2dioxygenas e Cluster295 602 Haemophil us influenzae Cluster424 3269 Transposas e IS3/IS911 Cluster404 1461 Uncharacte rised conserved protein UCP00628 7 Cluster299 9810 Natural resistanceassociated macrophag e protein 427 428 429 P44298 P44299 P44300 Urea Cyclophilin-like amidolyase superfamily -like domain 1 family Urea amidolyase subfamily Arginine repressor like domain family/ Cyclophilin-like superfamily No result AHS1 family No result No result E1-E2_ATPase family Allophanate hydrolase/ur ea amidolyaserelated -like domain family No result AHS2 family NRAMP family) Cluster – 140465 symporters, antiporters) AHS2 EC 3.1.-.-: Superfamily Hydrolases Acting on Ester Bonds (AcetylCoA carboxylase ) Cluster – DUR1 EC 4.1.-.-: 140465 Superfamily Lyases Carbon(AcetylCarbon CoA Lyases carboxylase ) Cluster – 122532 (ATP synthase subunit I) No result EC 3.1.-.-: Hydrolases Acting on Ester Bonds Cluster416 7582 Allophanat e hydrolase subunit 2 Cluster410 0812 Conserved hypothetica l protein CHP00370 Cluster407 7986 Bacteria