The Effect of Cyclic Loading on the Articular Cartilage of the FemoroAcetabular Joint by Taylor J. Castagna An Engineering Project Submitted to the Graduate Faculty of Rensselaer Polytechnic Institute in Partial Fulfillment of the Requirements for the degree of Master of Engineering Major Subject: Mechanical Engineering Approved: _________________________________________ Ernesto Gutierrez-Miravete, Project Adviser Rensselaer Polytechnic Institute Hartford, CT December, 2013 i CONTENTS The Effect of Cyclic Loading on the Articular Cartilage of the Femoro-Acetabular Joint i LIST OF TABLES ............................................................................................................ iv LIST OF FIGURES ........................................................................................................... v LIST OF SYMBOLS ....................................................................................................... vii ACRONYMS AND DEFINITIONS .............................................................................. viii KEYWORDS ..................................................................................................................... x ACKNOWLEDGMENTS ................................................................................................ xi ABSTRACT .................................................................................................................... xii 1. Introduction.................................................................................................................. 1 1.1 Background ........................................................................................................ 1 1.2 Problem Description........................................................................................... 2 2. Theory and Methodology ............................................................................................ 4 2.1 Theoretical Background ..................................................................................... 4 2.2 Numerical Analysis - Modeling ......................................................................... 5 2.2.1 Parts, Part Geometry, and Assembly...................................................... 6 2.2.2 Property Definition................................................................................. 7 2.2.3 Step Definition, Boundary Conditions, and Applied Loads ................ 10 2.2.4 Mesh ..................................................................................................... 15 3. Results and Discussion .............................................................................................. 17 3.1 Baseline Model Results .................................................................................... 17 3.2 Cyclic Load Results ......................................................................................... 21 3.2.1 Load Case Comparison ........................................................................ 21 3.2.2 Weight Comparison ............................................................................. 23 4. Conclusions................................................................................................................ 26 5. References.................................................................................................................. 28 6. Appendices ................................................................................................................ 29 ii 6.1 Excel Data for Strain Dependent Cartilage and Labrum ................................. 29 6.2 Excel Data for Loads as a Function of %BW .................................................. 30 6.3 Excel Data for Varying Load Cases as Inputs ................................................. 31 6.4 Excel Data for Varying Weights as Input Loads ............................................. 33 iii LIST OF TABLES Table 3.1 Tabular Results for Pore Pressure, Strain and Normal Contact Force for Differing Load Cases ....................................................................................................... 22 Table 3.2 Tabular Results for Pore Pressure, Strain and Normal Contact Force for Differing Weights ............................................................................................................ 24 Table 6.1 Input Data for Material Property of Strain Dependent Cartilage and Labrum 29 Table 6.2 Data Used for Development of Polynomial Functions for Walking, Jogging and Sprinting Loads ......................................................................................................... 30 Table 6.3 ABAQUS Input Data Developed from Polynomial Functions for Walking, Jogging and Sprinting (150 Lb Bodyweight) .................................................................. 32 Table 6.4 Varying Weights Represented as Contact Forces for ABAQUS Input Amplitudes....................................................................................................................... 33 iv LIST OF FIGURES Figure 1.1 (A) 3D View of the hip joint (B) View of the labral and cartilage attachment points [2] ............................................................................................................................ 1 Figure 2.1 Structure of articular cartilage with representation of proteoglycans, collagen and water concentration varying with depth [8] ................................................................ 5 Figure 2.2 Axisymmetric finite element geometry representation of the cartilage on the femoral head (dark green) and the cartilage with intact labrum (light green orange) which is attached to the subchondral bone of the acetabulum. .......................................... 7 Figure 2.3 Material orientation assignment for the in-plane and out-of-plane material properties in the labrum ................................................................................................... 10 Figure 2.4 ABAQUS screenshot of the interaction module (top-row) detailing the rigid surfaces and the contact interaction surfaces. The load module is also shown detailing the areas where pore pressure = 0 boundary condition is employed and necessary boundary conditions for axisymmetry are shown (bottom-row) ..................................... 11 Figure 2.5 Initial contact step with applied displacement ............................................... 12 Figure 2.6 Walking, Jogging, and Sprinting Polynomial Functions as Percentage of Body Weight.............................................................................................................................. 13 Figure 2.7 Cyclic Load Representation for 150 Lb Conditions of Walking, Jogging, and Sprinting .......................................................................................................................... 14 Figure 2.8 Graphical Representation of Varying Weights for ABAQUS Amplitude Input ......................................................................................................................................... 15 Figure 2.9 Mesh of CAX4P elements for both the intact labrum (top) and resected labrum (bottom) ............................................................................................................... 16 Figure 3.1 Fluid velocity vectors for an intact labrum (top) and resected labrum (bottom) for a 200 lb force being held for 100 seconds ................................................................. 18 Figure 3.2 Normal contact force represented as vectors at each element for an intact labrum (top) and resected labrum (bottom) at 1 second of full load application for a 200 lb load. ............................................................................................................................. 19 Figure 3.3 In-Plane strain for an intact labrum (left) and resected labrum (right) at 1 second of full load application for a 200 lb load. ............................................................ 20 v Figure 3.4 Graphical Results for Normal Contact Force for Differing Load Cases ........ 23 Figure 3.5 Graphical Results for Normal Contact Force for Differing Weights ............. 25 vi LIST OF SYMBOLS Symbol/Variable n Description Volume fraction of the voids to total volume Units - Vvoids Total volume of the voids in3 Vtotal Total volume of the solid matrix in3 e0 Void ratio as defined by ABAQUS at t=0 - λ Lame’s first constant for the solid matrix psi μ Lame’s second constant for the solid matrix psi πππ Principal elastic stressed for hyperelastic model psi ππ Principal stretch ratios for hyperelastic model - U Strain energy density function - πΌπ Material parameter for hyperelastic model π½ Material parameter for hyperelastic model k0 Permeability at t=0 in/s Strain dependent permeability in/s k(e) M Material constant for strain dependence - κ Material constant for strain dependence - Ep In-plane modulus of labrum psi Et Transverse modulus of labrum psi νp In-plane Poisson’s ratio of labrum νpt νtp Poisson’s ratio (labrum) for strain transverse resulting from stretch normal to it Poisson’s ratio (labrum) for strain in plane resulting from stretch normal to it - - Gp Shear modulus, in-plane of labrum psi Gt Shear modulus, transverse of labrum psi %BW Load as a percentage of body weight - vii ACRONYMS AND DEFINITIONS 1. Femoro-acetabular Joint –The joint in the human hip consisting of the femoral head, acetabulum, joint capsule, associated ligaments and articular cartilage. 2. Labrum – Located in the joint capsule attached to the acetabulum and made of primarily collagen. The primary focus of this paper, the labrum has been studied for its unique function which has been proposed as creating a seal for the joint fluid between the femur and acetabulum. 3. Excision – The term for removal of an organ, tissue, bone or tumor from a body. Significant to this research paper due to the surgical techniques employed for labrum pain consisting of removal of the labrum in its entirety or in a small section. Used interchangeably with the term “resection”. 4. Articular Cartilage – Soft, porous, composite material made up mostly of water and collagen found mainly in the joints of the human body as a bearing surface. Modeled in this paper as a biphasic material consisting of a solid matrix and a fluid that can permeate through the voids of the solid. 5. Cartilage Consolidation – The process by which a sustained load will cause increasing loads in the cartilage solid matrix due to exudation of fluid from the surface in contact. 6. Biphasic – A system that has two phases. In this case, the articular cartilage has a solid phase in the presence of collagen fibers and a fluid which can permeate between the voids made by the solid matrix. 7. Poroelasticity – The mechanical model detailing a porous elastic material permeated by an incompressible fluid. In this paper, used to model the articular cartilage and labrum. 8. ABAQUS – Commercial finite element code used for this research paper. 9. Gait cycle – The cycle by which a human walks; consists of the time span from when one foot contacts the ground to when that foot contacts the ground again. 10. Hyperelastic – A material model in which the stress-strain relationship derives from a strain energy density function. The cartilage in the finite element models found in this research paper are modeled by a hyperelastic (HYPERFOAM) viii model due to the large change in cartilage volume that can occur when undergoing compressive loading. 11. Transversely Isotropic – The description of a material in which the material properties are equivalent in the pain but differ perpendicular to the plane. The labrum is modeled as this type of material in the finite element code due to its specific orientation of collagen in the circumferential direction, or around the rim of the acetabulum. 12. CAX4P – A continuum axisymmetric 4-noded bilinear pore-pressure and bilinear displacement quadrilateral element. The element type chosen for the analyses performed in this paper due to its ability to transmit fluid pressure through compressive loading and to converge in a contact governed model. 13. POR – The abbreviation for the field variable in ABAQUS which calculates the pore pressure of the fluid at each integration point. 14. LE MAX PRINCIPAL – The abbreviation for the field variable in ABAQUS that represents the maximum principal logarithmic strain calculated at each integration point. 15. CNORM – The abbreviation for the field variable in ABAQUS that represents the normal contact force calculated at a surface specified in contact for each integration point on that surface. 16. Reference Point – The point in the model that all degrees of freedom are tied to when considering a rigid surface or part. In this paper abbreviated as “RP”. ix KEYWORDS 1. Labrum 2. Femoro-acetabular joint 3. Articular Cartilage 4. Finite Element Modeling 5. Poroelasticity x ACKNOWLEDGMENTS I would first like to thank my Project Adviser, Professor Ernesto, for hours spent offering helpful hints, guidance and pointed reviews on various topics. Secondly, I would like to thank any and all of the contributors to my reference page who have published similar papers on this subject. Without the thorough knowledge base put together by these members, this project would have never been possible. I would also like to thank my friends and family for the tons of support I was provided, including the very heartfelt understanding that they would not be seeing me (as much) until the completion of this degree. Lastly, I would like to thank my lovely girlfriend Allison. She was a constant source of inspiration and understanding when the times got tough, the hours got short, and the nights got late. I would have never made it through this without her. xi ABSTRACT The labrum of the femoro-acetabular joint provides an effective seal for the articulating cartilage surfaces on the head of the femur and in the acetabulum. Due to advancement in surgical techniques, removal of the labrum or excision is now commonly used to alleviate pain in patients subjected to labrum tears. The lack of a labrum providing an adequate seal for the cartilage in the joint may lead to increased cartilage consolidation during loading and therefore accelerated wear, creating more pain for the patient. The commercial finite element program, ABAQUS, was used to quantify the increase in the contact force between the articulating surfaces in the joint subjected to increasingly strenuous activities as well as changes in bodyweight. The results showed the normal contact force may increase up to 200% due to the lack of a functional labrum, implying a substantial risk for an increase in wear rates of the cartilage. Furthermore, the results showed increases in contact forces due to greater body weight and more strenuous activity, such as jogging when compared with walking in the absence of a labrum. xii 1. Introduction 1.1 Background In recent years, the management of hip and groin injuries has broadened significantly due to advancements in arthroscopic procedures. Minimally invasive surgical techniques allow for a relatively fast recovery for athletes in highly competitive environments and often a return to normal activity without pain. The advancements in magnetic resonance imaging (MRI) help explain the source of pain stemming from damage or deformities interior to the femoro-acetabular joint. A major result of advanced imaging techniques was the evaluation of acetabular labral tears, which are often left untreated. Given improvements in detecting tears, the acetabular labrum became a main focus for research due to a lack of understanding with regard to its function. The labrum in the human femoro-acetabular joint, located in the capsule of the hip, is attached to the circumference of the acetabular perimeter. As shown in Figure 1, the transverse acetabular ligament is connected to the labrum both anteriorly and posteriorly. The labrum is thinner in the anterior inferior section and thicker, with a slight roundness in appearance, in the posterior section. Free nerve endings have been identified within labral tissue, which may explain the pain pathway in a patient with a labral tear [1]. Figure 1.1 (A) 3D View of the hip joint (B) View of the labral and cartilage attachment points [2] 1 In an attempt to fully understand the pathology of, and study the range of surgical techniques to remove pain associated with, acetabular labrum tears, experiments and finite element modeling have been used to explain the labrum’s function as a part of the femoro-acetabular joint. Using a finite element model, Ferguson et al. demonstrate one of the most important functions of the joint, namely the labrum’s function as a seal for escaping fluid under normal loading between the articular cartilage on the femoral head and acetabulum [3], [4]. The labrum effectively prevents fluid from escaping the joint in order to retain a thin fluid film between the articulating surfaces allowing lubrication and transfer of the load via fluid pressure, which prevents premature wear of the cartilage surfaces by reducing cartilage consolidation. The authors attempted to replicate the findings of the model using an in vitro experiment, with similar results [5]. Song et al. used experimental results on cadaveric hips to show the friction increase from partial removal or complete removal of the acetabular labrum, further validating the hypothesized sealing function [6]. Using MRI techniques, a patient can be diagnosed with an acetabular labral tear and may choose to undergo surgery. In the event that the labrum cannot be fully repaired, excision, otherwise known as debridement, which is a complete or partial removal of the torn area, is implemented to relieve the pain. The surgery may also uncover a significant amount of work or damaged articular cartilage and may require micro-fracturing to elicit growth of new cartilage. As previously proven by Ferguson et al., if the labrum is no longer functioning as a seal to the joint fluid, cartilage consolidation will greatly increase [3]. Continued rotation of the femoral head within the joint during walking or exercising will wear away cartilage due to the increased friction and lack of fluid to develop hydrostatic pressure to carry the load. Therefore, a surgical technique used to re-grow cartilage may provide short-term pain relief but the long term effects of a debrided or damaged labrum will be problematic. 1.2 Problem Description The function of the acetabular labrum as a seal for the femoro-acetabular joint has been widely established through finite element modeling and in vitro experimentation. This knowledge allows refinement of surgical techniques and physical 2 therapy programs for patients suffering hip pain. If a patient requires excision of the labrum to relieve immediate pain, the long term effects on cartilage consolidation must be considered. A well known principle in tribology is an increase in the normal force on a material will lead to increased frictional forces and this often may expedite wear on the surface of the material. This project will seek to utilize the ability of finite element software to model a material as poroelastic, in this case the biphasic (liquid and solid) configuration of cartilage, and to explore how exposure to different loading conditions affect the strains and stresses in the solid matrix. The loading conditions in this case would be normal forces into the femoro-acetabular joint from daily activities such as walking and even more strenuous conditions including jogging. The intent is to determine whether there is a regimen a patient can follow after being diagnosed with a torn labrum that will limit the wear in articular cartilage and subsequent pain, ultimately leading to improved health and freedom from pain later in life. 3 2. Theory and Methodology 2.1 Theoretical Background A porous medium can be modeled in a commercial finite element code in which the medium is considered a biphasic material and adheres to the effective stress principle, which considers the total stress acting at a point to be made up of an average pressure stress and the solid matrix stress, in order to describe its behavior. The porous medium is considered to consist of a solid matrix and voids that can contain liquid. The constitutive behavior of the material is governed by the response of the liquid and solid matter to local pressure, or fluid flow, and the response of the solid matrix to effective stress [7]. The importance of a commercial code being able to model a porous medium is critical in analyzing geological systems such as soil containing ground water and the effect of forces on that system. For this project, the ability to model a porous media is also critical when considering biological systems, such as articular cartilage. Articular cartilage can be described as a soft, porous, composite material made up of collagen, proteoglycans, and water. Visually, articular cartilage is white with a smooth, shiny surface. The collagen and proteoglycans in the cartilage are intertwined to create a solid matrix of material. Typically, the volume of cartilage is made up of 80% water [8]. Cartilage is found between bony contact surfaces in the human body, otherwise known as joints. The percent compositions of the materials that make up cartilage vary with the depth of the cartilage, as shown in Figure 2.1. At the surface of the cartilage, the collagen fibers are oriented parallel to the surface, in the middle zone the orientation becomes more angled, and in the deep zone the collagen fibers begin to orient themselves perpendicular to the bone interface in order to properly anchor into the bone [8]. 4 Figure 2.1 Structure of articular cartilage with representation of proteoglycans, collagen and water concentration varying with depth [8] Due to the biphasic make up of articular cartilage, the intrinsic mechanical properties of each phase, the liquid and solid matrix, as well as the interaction between the phases, correspond to the interesting mechanical properties of the cartilage as a whole. Mow et al. was able to apply a linear nonhomogenous theory to accurately represent test data for an aggregate elastic modulus and permeability of the tissue [9]. Adaptations of these findings are used in conjunction with a commercial finite element code in order to run complex analyses to represent joints in the human body. 2.2 Numerical Analysis - Modeling The biphasic cartilage model detailed by Mow et al. demonstrated the mechanical properties of articular cartilage through an analytical solution [9]. In order to adequately analyze the joint contact mechanics within the irregular geometry of a human joint, an appropriate finite element code is required. J.Z. Wu, W. Herzog, and M. Epstein demonstrated the biphasic cartilage model can be implemented in the finite element code ABAQUS [10]. The results achieved in ABAQUS were comparable to analytical solutions as well as other finite element codes for three numerical tests: an unconfined indentation test, a test with the contact of a spherical cartilage surface with a rigid plate, and an axi-symmetric joint contact test [11]. Since ABAQUS has previously demonstrated a capacity to analyze the biphasic cartilage model proposed by Mow et al. and contact mechanics, it will be used herein. An axisymmetric model is used to reduce the number of elements in comparison to a three dimensional model. Although it has been shown the joint can be modelled as a two 5 dimensional plane-strain finite element mesh [4], the axisymmetric model alleviates the use of in-plane truss elements to represent the out-of-plane stiffness of the labrum. 2.2.1 Parts, Part Geometry, and Assembly In the ABAQUS part module, two 2D axisymmetric parts were created to represent the joint. The parts represent the articulating cartilage surfaces in the hip with an intact labrum and on the head of the femur, as shown in Figure 2.2. The light green represents the acetabular articular cartilage with the attachment to the rigid acetabulum, the dark green represents the femoral articular cartilage with the attachment to the rigid femur, and the orange represents the labrum with the attachment to the acetabulum. All corners, including the labrum to acetabulum interface, were modelled as sharp corners without radii for simplicity and ease in meshing. This assumption is reasonable as demonstrated by results in Haemer, Carter and Giori [12]. In the assembly, the parts were oriented with a common part reference point, which is used to tie the bone interface surface in each the femur and acetabulum. In this way, the loads and boundary conditions can be applied directly to the distinct reference points for each part. The axis of symmetry details the axis in which the each part is revolved around to represent the joint in three dimensional space. A second model was built in which the labrum was removed to represent a resected, or removed, labrum. The radius of the femur was set as 1.02 in. and the bone was modeled as rigid and impermeable. The articulating cartilage surfaces were modeled to have a thickness of 0.11 in. The joint was modeled as being fully congruent and the labrum was modeled as being in continuity with the articular cartilage [3], [12]. 6 Figure 2.2 Axisymmetric finite element geometry representation of the cartilage on the femoral head (dark green) and the cartilage with intact labrum (light green orange) which is attached to the subchondral bone of the acetabulum. 2.2.2 Property Definition The property module in ABAQUS allows for the definition of material properties and orientations. Since the material properties are equivalent for the acetabular and femoral articular cartilage, only two material definitions were required to represent both the cartilage and the labrum. For the cartilage, a hyperporoelastic material model was used due to the porosity of the material allowing large volumetric changes. The hyperelastic constitutive relation was based on the following: πππ = ππ πππ π = 1,2,3 2π (1) 1 πΌπ πΌπ πΌπ π −πΌπ π½ π = ∑π − 1)] π=1 πΌ2 [π1 + π2 + π3 − 3 + π½ ((π½) π 7 (2) where πππ and ππ (i=1,2,3) are the principal elastic stresses and the principal stretch ratios respectively; U is the strain energy function; J = π1 π2 π3 is the volume ratio; πΌπ , ππ (i=1…N), and β are material parameters [10]. The material parameters πΌπ are determined from equations π = 4πΌ0 πΌ2 , π = 2(πΌ1 + πΌ2 )πΌ0, and π½ = πΌ1 + 2πΌ2 in which π=1.89 psi, π=49.2 psi, and π½=0.761 [12]. ABAQUS represents the solid volume fraction as a void ratio (e0) based on the following: π= π½ππππ π (3) π½πππππ π ππ = (π−π) (4) where e0 for cartilage is 4. The specific weight of the pore fluid is γ=0.0361008 lb/in3 [3]. The permeability is dependent on the strain, which can be related directly to the void ratio based on the following equation: π π π 1+π 2 π(π) = π0 (π ) exp { 2 [(1+π ) − 1]} 0 0 (5) where k0=2.89355E-009 in/s, e is the void ratio, and e0 is the void ratio of the undeformed state, as defined above. M and κ are material constants which have been determined for cartilage to be 4.638 and 0.0848, respectively. A tabular form imported into the ABAQUS material property definition was used to define the strain dependent permeability over a void ratio range of 1.7 to 5 and is shown below in Appendix 6.1 [12]. The permeability of the labrum was set at one-sixth of articular cartilage, which is comparable to experimental results found by Ferguson et al. The strain-dependence of labrum permeability is not well defined and since the transverse properties of the cartilage compared with the labrum are of the same order, the strain-dependent permeability was adapted from the material constants of cartilage. However, an initial void ratio for the labrum was defined as 3, in lieu of 4 for cartilage as detailed in Appendix 6.1 [12]. The labrum is modeled as a transversely isotropic permeable elastic material in which the circumferential direction is the out-of-plane direction with differing material 8 properties considering the labrum’s unique pathology in which fibrils run in the circumferential direction, resulting in a greater stiffness. ABAQUS relates the stresses to the strains in each direction by the following tensor: where p and t stand for “in-plane” and “transverse” or out-of-plane, respectively [7]. In the case of Poisson’s ratio νtp characterizes the strain in the plane of isotropy resulting from stress normal to it, while νpt characterizes the transverse strain in the direction normal to the plane resulting from stress in the plane. These quantities are related by the following: ππ‘π π ⁄πΈ = ππ‘⁄πΈ π‘ π (6) For the labrum, the specific engineering constants were defined as Ep=80 psi, Et=29000 psi, νp=0.05, νtp=0.05, νpt=0.0001, and Gt=3.77 psi [12].The shear modulus inplane, Gp, is defined by: πΈπ πΊπ = 2(1+π π) (7) where Gp=38 psi. When engineering constants are used, a specific material orientation must be defined. The transverse isotropy defined for the labrum material is assigned with the orientation shown below, noting the 1 and 2 directions are in-plane while the 3rd direction, representing the circumferential oriented fibers in the labrum, is out-of-plane (Figure 2.3). 9 Figure 2.3 Material orientation assignment for the in-plane and out-of-plane material properties in the labrum 2.2.3 Step Definition, Boundary Conditions, and Applied Loads Since the articular cartilage and labrum are modeled as poroelastic materials, a coupled pore fluid diffusion and stress analysis was employed and a *SOILS step is required [7]. The opposing faces of cartilage are defined as contact surfaces, including the labrum surface in the applicable model, see Figure 2.4. Defining contact will allow pore fluid to flow between the surfaces that come into contact. The degree of freedom for pore fluid flow is no fluid flow across defined surfaces as the default in ABAQUS. Since this is the case, any free surface will employ a boundary condition that sets the pressure at this surface to zero. Through the analysis, fluid will enter or leave this surface to maintain this boundary condition. As previously stated, the surfaces in which the cartilage and labrum attach to bone are made rigid and impermeable. This assumption is reasonable since the material properties of bone are many magnitudes different compared to cartilage. The rigid surfaces are tied to reference points on the axis of symmetry. All loads and boundary conditions are applied to these reference points since ABAQUS will define all degrees of freedom for nodes on the rigid body by the 10 reference node. The acetabulum reference point is restrained in the radial and vertical directions. The loads are applied at the femur reference point in the vertical direction and are defined in section 2.2.3.2. In addition, axisymmetric boundary conditions are applied along the axis of symmetry to prevent movement and rotation (Figure 2.4). Figure 2.4 ABAQUS screenshot of the interaction module (top-row) detailing the rigid surfaces and the contact interaction surfaces. The load module is also shown detailing the areas where pore pressure = 0 boundary condition is employed and necessary boundary conditions for axisymmetry are shown (bottom-row) 11 2.2.3.1 Initial Contact Step The first step of the analysis is used to ensure good contact between the faces due to any differences in geometry. A small displacement of 0.002 in. is used on the reference point (RP) of the femur, shown in Figure 2.5. This boundary condition will be active in this step and then removed in all subsequent steps for load application. A separate boundary condition is applied and propagated to all subsequent steps to prevent left-right movement of the RP. A simply supported boundary condition (U1=U2=0) is applied to the RP of the acetabulum to prevent rigid body motion. For this step, a time period of 1 second is used and the steady-state consolidation assumption is used since the transient affects of fluid flow are not required at this point. Figure 2.5 Initial contact step with applied displacement 2.2.3.2 Load Application Step Once initial contact has been established, the necessary loads can be applied at the Femur RP. All loads were derived from the Fz direction detailed by Fabry, Hermann, Kaehler, Klinkenberg, Woernle and Bader for the walking load case [13]. Data points were developed from the hip contact force, as a percentage of bodyweight (%BW), over a normalized time scale (Appendix 6.2). A conservative estimate of cycle time for the 12 gait cycle at a moderate walking pace was taken to be 1 second. The data points were fit to a 6th order polynomial which will be used to develop the tabular input to be used in ABAQUS as an amplitude function (Figure 2.6). To develop load conditions for jogging and sprinting, the walking loads were amplified by 150% bodyweight and 200% bodyweight, respectively. The time scale was also modified from 1 second to 0.8 seconds for a jogging cycle and 1 second to 0.55 seconds for a sprinting cycle. Each cycle is taken to be from initial heel contact to the next increment of heel contact on the same leg. Combined % BW Loading With Trendlines Walking % BW 500 450 Jogging % BW 400 350 % Load (Fz) Sprinting % BW 300 250 Poly. (Walking % BW) y = -27962x6 + 87465x5 - 103145x4 + 58370x3 - 17298x2 + 2580x + 66.19 R² = 0.9898 Poly. (Jogging % BW) 200 150 100 y = -204262x6 + 505163x5 - 473217x4 + 213052x3 - 49737x2 + 5749.6x + 68.754 R² = 0.9943 Poly. (Sprinting % BW) 4 6 5 50 0 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 Time (seconds) 1 y = -2,858,684.52x + 4,840,189.88x - 3,109,233.68x + 960,451.20x3 - 153,272.38x2 + 12,035.17x + 71.32 R² = 1.00 Figure 2.6 Walking, Jogging, and Sprinting Polynomial Functions as Percentage of Body Weight The polynomial functions developed for the three load cases are based on %BW and they are appropriately scaled to represent the bodyweight of a 150 lb human. %BW was used in order to easily scale between differing body weights and magnitudes of loads. A model was created for all three cases, one set of each for the resected and intact labrum, totaling six models in all. The tabular data developed from the scaled 13 polynomial functions (Appendix 6.3) was input into ABAQUS as an amplitude function and applied at the Femur RP. Each load case was applied over five cycles (Figure 2.7). These inputs represent a consolidated system of various load conditions that can be imparted on the hip during daily activity or physical exertion. Combined Load Conditions (150 LB) 700 600 Load (Lbs) 500 Sprinting 150 Lb 400 300 Walking 150 Lb 200 Jogging 150 LB 100 0 0 1 2 3 Time (seconds) 4 5 Figure 2.7 Cyclic Load Representation for 150 Lb Conditions of Walking, Jogging, and Sprinting As a comparison, walking loading conditions were developed for a 200 lb and 250 lb human (Appendix 2.4) and are shown graphically in Figure 2.8. This requires creating two models each for an intact and resected labrum and providing the necessary inputs as an amplitude function. Similar to the varying load conditions for walking, jogging and running, these loads are applied over 5 cycles and in this case are a 5 second total step time. These conditions will serve to represent the effect on weight for intact and resected labrums. Inherently, an increase in weight is an increase in contact force since the formulation used is based on %BW. 14 Combined Weights for Walking 600 500 Load (Lbs) 400 200 Lb Human 150 Lb Human 300 250 Lb Human 200 100 0 0 0.1 0.2 0.3 0.4 0.5 0.6 Time (s) 0.7 0.8 0.9 1 Figure 2.8 Graphical Representation of Varying Weights for ABAQUS Amplitude Input 2.2.4 Mesh Figure 2.9 details the mesh refinement required for an accurate result. A mesh convergence study was performed resulting in the mesh density used. CAX4P, 4-noded axisymmetric quadrilateral, bilinear displacement, bilinear pore pressure elements were used to handle the effective stress of coupled pore pressure diffusion and stress analysis. 4-noded elements were used in lieu of 8-noded since the 4-noded elements behave better in contact. This resulted in a much denser mesh due to half the number of nodes used for each element. 15 Figure 2.9 Mesh of CAX4P elements for both the intact labrum (top) and resected labrum (bottom) 16 3. Results and Discussion 3.1 Baseline Model Results As a baseline, to ensure the properties and boundary conditions were reasonable, a 200 lb load was applied over 1 second and then held for 1000 seconds. Specifically, the fluid velocities represented as vector quantities at each node, the normal contact force between the articulating cartilage surfaces, and the in-plane strains were evaluated for an intact and resected labrum. The baseline model showed expected results for fluid velocities and normal contact forces; however it did present an unexpected result for strain. Numerical results are not tabulated for these results since the intent was to show representative strain, force, and fluid velocity results for an arbitrary load. The results are only for a comparison of visual representations of requested field variables. The results provided herein were of the same order of magnitude when compared to results found by Haemer, Carter and Giori [12]. For the fluid velocity, the field variable was taken at 100 seconds into the 1000 seconds step. The fluid velocity vectors for a model with an intact labrum, as displayed in Figure 3.1, show the labrum effectively “choking” the fluid as it is forced from the surface of the cartilage. The velocity significantly decreases at the interface and dissipates as the fluid continues into the cross section. There is a significant increase in the fluid velocity vectors on the periphery of the labrum over a very short length. Compared with the resected labrum, the fluid is escaping over a much larger area, which is congruent with the boundary conditions set for the free surface. The behavior of the fluid flow in the model shows the inputs are yielding expected results. 17 Figure 3.1 Fluid velocity vectors for an intact labrum (top) and resected labrum (bottom) for a 200 lb force being held for 100 seconds The normal contact force field variable was evaluated after the 1 second ramp load was applied, as shown in Figure 3.2, to obtain the maximum contact force before the cartilage began to consolidate and the fluid pressure was redistributed. As expected, the labrum adds a significant amount of contact area to the articulating cartilage surface of the femur. This allows the force to be more evenly distributed over the cartilage of the 18 femoral head, resulting in a relatively smaller contact force. Since the model with the resected labrum has a diminished contact area, the contact force showed a higher peak force and a distribution that shifted the force towards the centerline of the joint. Figure 3.2 Normal contact force represented as vectors at each element for an intact labrum (top) and resected labrum (bottom) at 1 second of full load application for a 200 lb load. Similar to the normal contact force field variable, the in-plain strain was evaluated after 1 second, which is the maximum value prior to cartilage consolidation. The results 19 showed a higher strain in the femoral and acetabular cartilage in the resected labrum model compared with the intact labrum as expected, however the area of highest strain contour was of particular interest. Figure 3.3 shows the areas of highest strain (light green) were at the cartilage to bone interface, not at the articulating surface (light blue). The smaller magnitude of strain at the contact surface does not explain how patients will show degraded and worn cartilage at the articular surface during hip arthroscopy. The significance is that even with the baseline model the results show the normal contact force will be the driving component when evaluating cartilage wear. Figure 3.3 In-Plane strain for an intact labrum (left) and resected labrum (right) at 1 second of full load application for a 200 lb load. 20 3.2 Cyclic Load Results For comparison of the results, the field variables of pore pressure (POR), maximum strain (LE Max Principal), and normal contact force (CNORM) are extracted from the steps at the peak of each load cycle. The results are broken into two separate sections for comparison in order to correlate between the differing load cases of walking, running and sprinting as well as the effect of the increase in weight on the extracted field variables from the analyses. 3.2.1 Load Case Comparison As shown in Table 3.1, the pore pressure, strain, and normal contact force are reported at the peak load application in each model. The pore pressure is shown in order to demonstrate the lack of transient effects from the loading and unloading in the joint. The pressure is fairly constant at the peak of each load cycle, dictating the load carried by pore pressure does not change through the cycles. Also, the pore pressure is much higher in models with a resected labrum but the pore pressure maximum occurs at the centerline of the joint, dictating that the freely draining surfaces do not expunge enough fluid to lower the pore pressure at the joint centerline. Although it provides a reasonable seal in the baseline model the intact labrum represents an area in which the fluid may redistribute itself into causing pressures on the order of magnitude of 20% smaller between the model with the resected labrum and intact labrum. The maximum strain, as previously shown in the baseline model, occurs at the bone interface, which does not explain degradation of cartilage on the articulating surfaces. Since this is the case, the maximum strain is reported in Table 3.1 to show the removal of a labrum will also increase the maximum strain gradient, which may eventually propagate to the articulating surface with increasing loads. Of particular interest, based on results from the baseline model, is the contact force between opposing faces of cartilage on the acetabulum and femur. The comparison of the computed contact force, between the intact labrum model and resected labrum 21 model, shows an average percent increase of 160%, 170%, and 155% for walking, jogging and sprinting. Table 3.1 Tabular Results for Pore Pressure, Strain and Normal Contact Force for Differing Load Cases 150 Lb Walking Intact Labrum Step Time (s) 0.2 1.2 2.2 3.2 Pore Pressure (psi) 149.7 149.2 148.3 147.0 LE Max. Principal 0.092 0.091 0.091 0.090 Contact Force (Lb) 0.276 0.277 0.276 0.274 150 Lbs Walking Resected Labrum 4.2 0.2 1.2 2.2 3.2 146.8 173.6 175.3 172.8 172.0 0.090 0.127 0.128 0.128 0.127 0.274 0.756 0.709 0.709 0.707 4.2 0.2 1.0 1.8 2.6 170.9 222.4 220.9 220.0 220.0 0.126 0.136 0.135 0.135 0.135 0.705 0.359 0.359 0.358 0.358 150 Lb Jogging Resected Labrum 3.4 0.2 1.0 1.8 2.6 218.9 257.6 257.6 288.3 254.7 0.134 0.189 0.189 0.188 0.186 0.358 0.974 0.976 0.971 0.967 150 Lb Sprinting Intact Labrum 3.4 0.1 0.65 1.2 1.75 253.6 296.0 296.6 293.9 293.9 0.187 0.181 0.181 0.180 0.180 0.966 0.446 0.447 0.445 0.446 150 Lb Sprinting Resected Labrum 2.3 0.1 0.65 1.2 1.75 293.5 344.2 347.3 345.7 346.1 0.180 0.471 0.471 0.471 0.471 0.446 1.135 1.132 1.143 1.145 2.3 345.7 0.470 1.145 Load Case 150 Lb Jogging Intact Labrum 22 Load Case Comparison Results 1.4 1.2 150 Lbs Walking Intact Labrum CNORM (Lbs) 1 150 Lbs Walking Resected Labrum 0.8 0.6 150 Lbs Jogging Intact Labrum 0.4 150 Lbs Jogging Resected Labrum 0.2 150 Lbs Sprinting Intact Labrum 0 0 1 2 3 Time 4 5 150 Lbs Sprinting Resected Labrum (s-1) Figure 3.4 Graphical Results for Normal Contact Force for Differing Load Cases 3.2.2 Weight Comparison Similar to the comparison for load cases, the increase in weight has a significant impact on the normal contact force in the joint. The comparison of the computed contact force, between the intact labrum model and resected labrum model, shows an average percent increase of 160%, 220%, and 170% for the differing weights shown in Table 3.2. Again, the pore pressure and maximum strain are reported but are not of particular interest. For the weight comparison, the pore pressure and maximum strain show equivalent traits to the information provided in section 3.2.1. 23 Table 3.2 Tabular Results for Pore Pressure, Strain and Normal Contact Force for Differing Weights Load Case 150 Lb Walking Intact Labrum 150 Lb Walking Resected Labrum 200 Lb Walking Intact Labrum 200 Lb Walking Resected Labrum 250 Lb Walking Intact Labrum 250 Lb Walking Resected Labrum Step Time (s) 0.2 1.2 2.2 Pore Pressure (psi) 149.7 149.2 148.3 LE Max. Principal 0.092 0.091 0.091 CNORM (Lb) 0.276 0.277 0.276 3.2 147.0 0.090 0.274 4.2 0.2 1.2 2.2 3.2 146.8 173.6 175.3 172.8 172.0 0.090 0.127 0.128 0.128 0.127 0.274 0.756 0.709 0.709 0.707 4.2 0.2 1.2 2.2 170.9 198.8 197.3 197.1 0.126 0.122 0.121 0.121 0.705 0.334 0.333 0.333 3.2 195.7 0.120 0.333 4.2 0.2 1.2 2.2 3.2 195.8 228.7 228.3 227.3 227.6 0.120 0.311 0.311 0.310 0.311 0.333 0.978 1.083 1.063 1.056 4.2 0.2 1.2 2.2 228.4 241.8 248.0 245.1 0.310 0.152 0.152 0.150 1.092 0.387 0.389 0.385 3.2 245.4 0.150 0.380 4.2 0.2 1.2 2.2 3.2 244.8 284.4 283.9 283.6 283.0 0.150 0.390 0.390 0.390 0.389 0.380 1.093 1.031 1.017 1.015 4.2 282.6 0.389 1.011 24 Weight Comparison Results 1.2 150 Lbs Walking Intact Labrum CNORM (Lbs) 1 0.8 150 Lbs Walking Resected Labrum 0.6 200 Lbs Walking Intact Labrum 0.4 200 Lbs Walking Resected Labrum 0.2 250 Lbs Walking Intact Labrum 0 0 1 2 3 4 5 250 Lbs Walking Resected Labrum Time (s-1) Figure 3.5 Graphical Results for Normal Contact Force for Differing Weights 25 4. Conclusions The following conclusions can be drawn from this research. Specifically, the cyclic loads, although repetitive in nature, do not influence the cartilage consolidation as much as the magnitude of the loads. The most significant finding from the results of the research was the drastic increase of the computed normal contact forces when compared between models with a labrum and without a labrum. The model results suggest that the presence of a labrum creates a much larger contact area for distribution of loads, prevents the exudation of fluid, and allows the fluid an area for redistribution under load. In the case of the model without the labrum, the solid phase of the cartilage would be required to carry a greater percentage of the load versus the load being carried by fluid pressure. It is well established that the constant of proportionality, the coefficient of friction, relates the normal load to the friction force. An increase in contact force in the model with the resected labrum can be correlated to an increase in resulting frictional forces. Although the model did not provide any rotational motion, one can visualize the effect of rotation on the joint in the case of increasing contact forces. Therefore, a larger frictional force would provide a greater force for shearing of the articulating surfaces of the cartilage. The cartilage on the articulating surfaces would wear away at an accelerated rate with increasing normal contact loads, eventually resulting in pain through many cycles and evolutions due to bone-on-bone contact. The results of the research, through the different loading conditions and weight comparisons, suggest that in the absence of a functional labrum, or in the case of a labrum that has been surgically removed, the normal contact forces increase with an increase in weight and more strenuous activities. For patients, this would mean focusing on diet to maintain a reasonable weight and avoiding strenuous activities for long periods of time, which may limit pain later in life. 26 27 5. References [1] A. S. Ranawat and B. T. Kelly, “Function of the Labrum and Management of Labral Pathology,” Hip Arthrosc., vol. 15, no. 3, pp. 239–246, Jul. 2005. [2] C. R. Henak, B. J. Ellis, M. D. Harris, A. E. Anderson, C. L. Peters, and J. A. Weiss, “Role of the acetabular labrum in load support across the hip joint,” J. Biomech., vol. 44, no. 12, pp. 2201–2206, Aug. 2011. [3] S. J. Ferguson, J. T. Bryant, R. Ganz, and K. Ito, “The acetabular labrum seal: a poroelastic finite element model,” Clin. Biomech., vol. 15, no. 6, pp. 463–468, Jul. 2000. [4] S. . Ferguson, J. . Bryant, R. Ganz, and K. Ito, “The influence of the acetabular labrum on hip joint cartilage consolidation: a poroelastic finite element model,” J. Biomech., vol. 33, no. 8, pp. 953–960, Aug. 2000. [5] S. J. Ferguson, J. T. Bryant, R. Ganz, and K. Ito, “An in vitro investigation of the acetabular labral seal in hip joint mechanics,” J. Biomech., vol. 36, no. 2, pp. 171– 178, Feb. 2003. [6] Y. Song, H. Ito, L. Kourtis, M. R. Safran, D. R. Carter, and N. J. Giori, “Articular cartilage friction increases in hip joints after the removal of acetabular labrum,” J. Biomech., vol. 45, no. 3, pp. 524–530, Feb. 2012. [7] “ABAQUS 6.11 Documentation.” . [8] A. Neville, A. Morina, T. Liskiewicz, and Y. Yan, “Synovial joint lubrication — does nature teach more effective engineering lubrication strategies?,” Proc. Inst. Mech. Eng. Part C J. Mech. Eng. Sci., vol. 221, no. 10, pp. 1223–1230, Jan. 2007. [9] V. C. Mow, S. C. Kuei, W. M. Lai, and C. G. Armstrong, “Biphasic Creep and Stress Relaxation of Articular Cartilage in Compression: Theory and Experiments,” J. Biomech. Eng., vol. 102, no. 1, pp. 73–84, Feb. 1980. [10] J. Z. Wu and W. Herzog, “Analysis of the mechanical behavior of chondrocytes in unconfined compression tests for cyclic loading,” J. Biomech., vol. 39, no. 4, pp. 603–616, 2006. [11] J. . Wu, W. Herzog, and M. Epstein, “Evaluation of the finite element software ABAQUS for biomechanical modelling of biphasic tissues,” J. Biomech., vol. 31, no. 2, pp. 165–169, May 1997. [12] J. M. Haemer, D. R. Carter, and N. J. Giori, “The low permeability of healthy meniscus and labrum limit articular cartilage consolidation and maintain fluid load support in the knee and hip,” J. Biomech., vol. 45, no. 8, pp. 1450–1456, May 2012. [13] C. Fabry, S. Herrmann, M. Kaehler, E.-D. Klinkenberg, C. Woernle, and R. Bader, “Generation of physiological parameter sets for hip joint motions and loads during daily life activities for application in wear simulators of the artificial hip joint,” Med. Eng. Phys., vol. 35, no. 1, pp. 131–139, Jan. 2013. 28 6. Appendices 6.1 Excel Data for Strain Dependent Cartilage and Labrum The data provided is established using equation (5) provided below, established in section 2.2.2: π π π 1+π 2 π(π) = π0 ( ) exp { [( ) − 1]} π0 2 1 + π0 9.81 kN/m^3 7.50E-15 m^4/N*s 8.02E-08 in^4/lb*s M k = = = 0.036101 lb/in^3 Specific Weight of Fluid = 8.02E-08 in^4/lb*s Unit Volume Permeability = 2.89E-09 in/s Permeability of Cartilage = 4.82E-10 in/s Permeability of Labrum 4.638 0.0848 Table 6.1 Input Data for Material Property of Strain Dependent Cartilage and Labrum Strain Dependent Cartilage Permeability (in/s) 5.20556E-10 5.50465E-10 5.8302E-10 6.18501E-10 6.57221E-10 6.99527E-10 7.45808E-10 7.96499E-10 8.5209E-10 9.13129E-10 9.80235E-10 1.0541E-09 1.13552E-09 1.22538E-09 1.32467E-09 1.43454E-09 1.55629E-09 1.69136E-09 1.84144E-09 2.00842E-09 2.19447E-09 Strain Dependent Labrum Void Ratio 1.7 1.8 1.9 2 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3 3.1 3.2 3.3 3.4 3.5 3.6 3.7 29 Permeability (in/s) 1.30046E-10 1.41521E-10 1.54416E-10 1.68935E-10 1.85316E-10 2.03836E-10 2.24819E-10 2.48642E-10 2.75747E-10 3.06652E-10 3.41968E-10 3.82415E-10 4.2884E-10 4.82248E-10 5.43831E-10 6.15004E-10 6.97453E-10 7.9319E-10 9.0462E-10 1.03463E-09 1.18668E-09 Void ratio 1.7 1.8 1.9 2 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3 3.1 3.2 3.3 3.4 3.5 3.6 3.7 2.40205E-09 2.634E-09 2.89355E-09 3.1844E-09 3.51082E-09 3.87771E-09 4.29069E-09 4.75626E-09 5.28191E-09 5.87632E-09 6.54951E-09 7.3131E-09 8.1806E-09 3.8 3.9 4 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 5 1.36494E-09 1.57444E-09 1.82127E-09 2.11281E-09 2.458E-09 2.86774E-09 3.35536E-09 3.93711E-09 4.63293E-09 5.46735E-09 6.47052E-09 7.67971E-09 9.14101E-09 3.8 3.9 4 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 5 6.2 Excel Data for Loads as a Function of %BW The data provided below is adapted from the Fz direction provided in the paper by Fabry, Hermann, Kaehler, Klinkenberg, Woernle and Bader [13]. This information was plotted in excel and a polynomial function of the 6th power was fit. Gait Time Jogging= Gait Time Sprinting= Load Increase Jog= Load Increase Sprint= 0.8 s 0.55 s 1.5 Magnitude 2 Magnitude Table 6.2 Data Used for Development of Polynomial Functions for Walking, Jogging and Sprinting Loads Gait Time (Sprinting) 0 0.022 0.0275 0.0385 0.0495 0.055 0.0605 0.066 Force %BW Walking 75 140 150 170 195 200 205 211 Force %BW Jogging 75 210 225 255 292.5 300 307.5 316.5 30 Force %BW Sprinting 75 280 300 340 390 400 410 422 0.0715 0.07425 0.077 0.0825 0.088 0.0935 0.099 0.1045 0.11 0.1155 0.132 0.143 0.1485 0.154 0.1595 0.165 0.1705 0.198 0.209 0.22 0.231 0.2365 0.242 0.2475 0.253 0.264 0.286 0.308 0.33 0.341 0.4675 0.55 213 215 216 217 219 220 220 221 222 221 219 218 217 215 213 210 208 204 204 204 205 205 203 199 196 189 172 156 120 100 30 75 319.5 322.5 324 325.5 328.5 330 330 331.5 333 331.5 328.5 327 325.5 322.5 319.5 315 312 306 306 306 307.5 307.5 304.5 298.5 294 283.5 258 234 180 150 45 75 426 430 432 434 438 440 440 442 444 442 438 436 434 430 426 420 416 408 408 408 410 410 406 398 392 378 344 312 240 200 60 75 6.3 Excel Data for Varying Load Cases as Inputs The data provided is developed from the polynomial functions provided in Appendix 6.2 and Figure 2.6. This data was exported to a text file and then read into the ABAQUS amplitude function to provide the necessary cyclic representation of the gait cycle. The data provided is applicable to the walking, jogging and sprinting loads during 5 cycles. 31 Table 6.3 ABAQUS Input Data Developed from Polynomial Functions for Walking, Jogging and Sprinting (150 Lb Bodyweight) Gait Time (Walking) 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3 3.1 3.2 3.3 Force 150 Lb Bodyweight Walking 75 300.168282 327.595848 324.061728 310.180872 266.62875 185.881992 93.760068 40.768008 63.240162 114.285 300.168282 327.595848 324.061728 310.180872 266.62875 185.881992 93.760068 40.768008 63.240162 114.285 300.168282 327.595848 324.061728 310.180872 266.62875 185.881992 93.760068 40.768008 63.240162 114.285 300.168282 327.595848 324.061728 Gait Time (Jogging) 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3 3.1 3.2 3.3 Force 150 Lb Bodyweight Jogging 75 475.382502 487.563288 472.934088 401.788152 239.23725 82.394712 76.955508 113.173368 475.382502 487.563288 472.934088 401.788152 239.23725 82.394712 76.955508 113.173368 475.382502 487.563288 472.934088 401.788152 239.23725 82.394712 76.955508 113.173368 475.382502 487.563288 472.934088 401.788152 239.23725 82.394712 76.955508 113.173368 475.382502 32 Gait Time (Sprinting) Force 150 Lb Bodyweight Sprinting 0 0.025 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45 0.5 0.55 0.6 0.65 0.7 0.75 0.8 0.85 0.9 0.95 1 1.05 1.1 1.15 1.2 1.25 1.3 1.35 1.4 1.45 1.5 1.55 1.6 1.65 75 435.355608 655.7532681 645.6154286 633.2655763 586.4965276 468.603782 293.5648472 132.9782621 74.7623191 133.6134844 113.2245169 435.355608 655.7532681 645.6154286 633.2655763 586.4965276 468.603782 293.5648472 132.9782621 74.7623191 133.6134844 113.2245169 435.355608 655.7532681 645.6154286 633.2655763 586.4965276 468.603782 293.5648472 132.9782621 74.7623191 133.6134844 113.2245169 3.4 3.5 3.6 3.7 3.8 3.9 4 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 5 310.180872 266.62875 185.881992 93.760068 40.768008 63.240162 114.285 300.168282 327.595848 324.061728 310.180872 266.62875 185.881992 93.760068 40.768008 63.240162 114.285 3.4 3.5 3.6 3.7 3.8 3.9 4 487.563288 472.934088 401.788152 239.23725 82.394712 76.955508 113.173368 1.7 1.75 1.8 1.85 1.9 1.95 2 2.05 2.1 2.15 2.2 2.25 2.3 2.35 2.4 2.45 2.5 2.55 2.6 2.65 2.7 2.75 435.355608 655.7532681 645.6154286 633.2655763 586.4965276 468.603782 293.5648472 132.9782621 74.7623191 133.6134844 113.2245169 435.355608 655.7532681 645.6154286 633.2655763 586.4965276 468.603782 293.5648472 132.9782621 74.7623191 133.6134844 113.2245169 6.4 Excel Data for Varying Weights as Input Loads The data provided is developed from the polynomial functions provided in Appendix 6.2 and Figure 2.6. This data was exported to a text file and then read into the ABAQUS amplitude function to provide the necessary cyclic representation of the gait cycle. The provided data is applicable to walking with a bodyweight of 150 lbs, 200 lbs and 250 lbs over 5 cycles. Table 6.4 Varying Weights Represented as Contact Forces for ABAQUS Input Amplitudes Gait Time (Walking) Force 150 Lb Bodyweight Walking Force 200 Lb Bodyweight Walking Force 250 Lb Bodyweight Walking 0 0.1 0.2 99.285 300.168282 327.595848 132.38 400.224376 436.794464 165.475 500.28047 545.99308 33 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 4 4.1 4.2 4.3 324.061728 310.180872 266.62875 185.881992 93.760068 40.768008 63.240162 114.285 300.168282 327.595848 324.061728 310.180872 266.62875 185.881992 93.760068 40.768008 63.240162 114.285 300.168282 327.595848 324.061728 310.180872 266.62875 185.881992 93.760068 40.768008 63.240162 114.285 300.168282 327.595848 324.061728 310.180872 266.62875 185.881992 93.760068 40.768008 63.240162 114.285 300.168282 327.595848 324.061728 432.082304 413.574496 355.505 247.842656 125.013424 54.357344 84.320216 152.38 400.224376 436.794464 432.082304 413.574496 355.505 247.842656 125.013424 54.357344 84.320216 152.38 400.224376 436.794464 432.082304 413.574496 355.505 247.842656 125.013424 54.357344 84.320216 152.38 400.224376 436.794464 432.082304 413.574496 355.505 247.842656 125.013424 54.357344 84.320216 152.38 400.224376 436.794464 432.082304 34 540.10288 516.96812 444.38125 309.80332 156.26678 67.94668 105.40027 190.475 500.28047 545.99308 540.10288 516.96812 444.38125 309.80332 156.26678 67.94668 105.40027 190.475 500.28047 545.99308 540.10288 516.96812 444.38125 309.80332 156.26678 67.94668 105.40027 190.475 500.28047 545.99308 540.10288 516.96812 444.38125 309.80332 156.26678 67.94668 105.40027 190.475 500.28047 545.99308 540.10288 4.4 4.5 4.6 4.7 4.8 4.9 5 310.180872 266.62875 185.881992 93.760068 40.768008 63.240162 114.285 413.574496 355.505 247.842656 125.013424 54.357344 84.320216 152.38 35 516.96812 444.38125 309.80332 156.26678 67.94668 105.40027 190.475