Human Physiology Unit 3C:
Blood
Supplemental Instruction
Iowa State University
Leader:
Course:
Instructor:
Date:
Kristin Potts
BIOL 256
Dr. Karri Haen
March 10, 2013
Blood
1. What are the three main functions of blood?
2. What is blood plasma called after blood clotting occurs?
3. What is another word for “The ratio of RBC by total volume of blood?”
Type
Plasma
Formed
Elements
Percent (%)
Composition
a.
b.
i.
Control osmotic pressure and transport steroid hormones
ii.
Gamma: Immunoglobulins, antibodies
Alpha/Beta: Transport iron, fats
iii.
Fibrinogen: major clotting protein
c. Solutes
a.
b.
c.
Buffy Coat
Formed Elements
1. Which type of cell has a “biconcave disk” shape?
2. True or False: Erythrocytes have nuclei and mitochondria
3. What is the main function of a RBC?
What molecule does it use to achieve this?
a. ____________: 2 alpha and 2 beta polypeptides
b. Each polypeptide has an iron-containing ______, which
carries __________
c. Per 1 molecule of hemoglobin, how many molecules of
oxygen are transported?
Matching. Select the best option to match the following statements:
1. ___ Hemoglobin after oxygen diffuses into tissues (delivery)
2. ___ Hemoglobin bound to carbon monoxide, turns cherry red
3. ___ Hemoglobin bound to Cyanide, turns heme blue, fatal
4. ___ Hemoglobin bound to oxygen (loading in lungs)
5. ___ Hemoglobin bound to carbon dioxide (loading in tissues)
a.
b.
c.
d.
e.
Oxyhemoglobin
Deoxyhemoglobin
Carbaminohemoglobin
Cyanohemoglobin
Carboxyhemoglobin
Supplemental Instruction
1060 Hixson-Lied Student Success Center  294-6624  www.si.iastate.edu
Formed Elements Production
1. What is hematopoiesis?
a. What is the term for RBC production?
b. What is the term for WBC production?
2. Where are blood cells produced?
3. What hormone stimulates RBC production?
Which organ releases it?
4. Which organs are responsible for breaking down old RBCs and heme?
5. Which molecules recycle the Iron from heme?
6. Heme is converted into what?
How is it excreted?

KNOW normal hematocrit and hemoglobin levels for a male and female!
Male
Female
Hematocrit:
Hematocrit:
Hemoglobin:
Hemoglobin:
Erythrocyte Disorders
__________: Blood with abnormally low oxygen-carrying capacity
1. Insufficient Erythrocytes
a. ______________________: Result of a loss of blood
b. ______________________: Prematurely ruptured erythrocytes
c. ______________________: Destruction/Inhibition of red bone marrow
2. Decreased Hemoglobin Content
a. ______________________: Inadequate intake of iron-containing foods
b. ______________________: Deficiency of Vitamin B12
Supplemental Instruction
1060 Hixson-Lied Student Success Center  294-6624  www.si.iastate.edu
3. Abnormal Hemoglobin
a. ____________________: Absent or faulty _________ chain in hemoglobin
b. ____________________: Defective gene encoding for _____________
_______________: Increase in RBC, making blood viscous and increasing BP as a result
a. ________________________: Bone marrow cancer
b. ________________________: Decrease in Oxygen due to altitude
c. ________________________: Athlete removes blood and saves for later use
Leukopoiesis
1. Hormonally stimulated by which two families of cytokines?
2. From what type of cells do all WBC originate?
3. Hemocytoblasts differentiate into:
a. Myeloid Stem Cells 
i. Myeloblasts 
ii. Monoblasts 
b. Lymphoid Stem Cells 
i. Lymphoblasts 
Blood Types
1. ______________ aka Antigens (Ag) expressed on blood cells
2. Two main systems:
3. ________________ spontaneously form against A, B or Rh antigen if not present on individual’s
blood cells
4. _________________________: If mother is Rh- and fetus is Rh+, then mother’s antibodies attack
fetus and results in a miscarriage
Blood Type
RBC antigen
Serum Reaction
Anti-A
AB
A
B
O
Anti-B
A and B
A
B
None
Supplemental Instruction
1060 Hixson-Lied Student Success Center  294-6624  www.si.iastate.edu