Buy and Cell “Did you lose weight?” Y 100 100 100 100 100 200 200 200 200 200 300 300 300 300 300 400 400 400 400 400 500 500 500 500 500 Stop, Drop Thanksgiving and Roll These 3 types of cells are all considered lymphocytes. What are T, B, and NK cells? This cell is the blood precurser to macrophages. What are monocytes? These 3 types of cells are all considered granulocytes. What are neutrophils, basophils, and eosinophils? This type of blood cell has no MHC on its surface. What are RBC’s or erythrocytes? These cells are the precursor to platelets. What are megakaryocytes? This is how the alternative pathway of the complement system is activated. What is spontaneously? These 2 types of antibodies are most likely to activate the complement system via the classical pathway. What are IgM and IgG? These are the five proteins that make up the membrane attack complex. What are C5b, C6, C7, C8, and C9? The lectin pathway of complement activation is initiated when a lectin binds to this type of molecule. What is a carbohydrate? (mannose acceptable) Another role of complement proteins is to prepare pathogens for phagocytosis, a process known as this. What is opsonization? This is the default antibody class. What is IgM? This is the process by which a B cell changes the type of antibody it produces. What is class switching? This process is the result of somatic hypermutation of antibody genes. What is affinity maturation? If you add the number of antibodies found in the most commonly secreted forms of IgM, IgG, IgA, and IgE, you arrive at this number. What is 9? These cells reside in the spleen or bone marrow and secrete up to 2000 antibody molecules each second. What are plasma cells? This is what a male turkey is called. What is a Tom? This character has had the most balloons made of him for the Macy’s Thanksgiving Day Parade Who is Snoopy? This is the name of the rock on which the Pilgrim’s landed What is Plymouth Rock? This Indian tribe celebrated the first Thanksgiving with the Pilgrims. Who are the Wampanoag? He was the first commander of the Pilgrim’s militia Who is Miles Standish? This family of molecules is involved in the initial slowing down of leukocytes as they approach a sight of infection. What are selectins? This family of molecules causes leukocytes to stop rolling. What are integrins? These are ligands for integrins found on leukocytes. What are ICAMs? (or VCAMs) This cell marker is lost in LAD-1. What is CD18? This component of Eand P-selectin ligands is lost in LAD-2. What is Sialyl x Lewis ?