II BRAZILIAN-TURKISH
NANOTECHNOLOGY WORKSHOP
Sibele B. C. Pergher
UFRN
UFRN
Rectory
Numbers
2
Plasmatic Level
Drug Delivery
Toxic Range
Therapeutic Range
Sub Therapeutic Range
Time
(days)
3
Drug Delivery
Synthesis of new hybrid materials from montmotillonite
and biopolymer for Olanzapine delivery
Artur de Santana Oliveira and Sibele Pergher
T
O
gada
0,97nm
amente
T
Cations
cáveis
T
O
Olanzapine Structure
T
Montmorillonite Structure
LABPEMOL- Laboratório
de Peneiras Moleculares
Sibele Pergher
4
Drug Delivery
Xanthan Gum
Alginate
LABPEMOL- Laboratório de Peneiras Moleculares
Sibele Pergher
5
Drug Delivery
LABPEMOL- Laboratório de Peneiras Moleculares
Sibele Pergher
6
Drug Delivery
Projects in development
 Study of the effect of dexamethasone combined with multifunctional
gold nanoparticles on inflammatory response of experimental oral
mucositis: targeted and photothermal therapy- Caroline A. C. X. de
Medeiros
 Assessment of the effects of gold nanoparticles in cancer cells Raimundo F. de Araujo Junior
 Development of Nanostructured Lipid Carrier containing oily fraction
of BIXA ORELLANA l. as alternative therapy in the treatment of
leishmaniasis - Fernanda N. Raffin
 Collection and characterization of polymeric nanolattices with low
concentration of surfactant for biomedical applications - Juliana de S.
Nunes
7
Drug Delivery
Projects in development
 Extraction of silk fibers nanoparticles and their potential application in
drug delivery nano systems - Rasiah Ladchumananandasivam
 Development and characterization of nanoparticles containing copaiba
essential oil for the treatment of infectious diseases - Eryvaldo
Socrates Tabosa Do Egito
 Development of mesoporous magnetic nanoparticles for application in
hyperthermia and controlled release of drugs - Artur da Silva Carrico
8
Nanomaterials
Sensors and Actuators B 196 (2014) 306–313
LENA: Laboratório de Eletroquímica e
Nanopartículas Aplicadas
Luiz Henrique Gasparotto
9
Nanomaterials
RSC Adv., 2015, 5, 66886
LENA: Laboratório de Eletroquímica e
Nanopartículas Aplicadas
Luiz Henrique Gasparotto
10
Laboratory of Environmental and Applied Electrochemistry – Prof. Carlos A Martinez Huitle (carlosmh@quimica.ufrn.br)
Water purification by nanomotors
Mg-nanomotors for removing Nitrite from
A
B
water
Aim: Use of Mg-nanomotor for rapid and effective
remeadiation
of
nitrite
from
drinking
water/groundwater.
Motivation: Nitrite is a toxic inorganic
contaminant that is hazardous to the health of
humans.
Approach: Mg nanoparticle is used to reduce the
nitrite into ammonia (60-95%) and nitrogen.
NO2- + 2Mg + 3H2O → NH3 + 2Mg(OH)2 + OH2NO2- + 2Mg + 4H2O → N2 + 2Mg(OH)2 + 2OHa
Abs.
D
Mg-nanomotors
0.3
O2
C
SEM images illustrating the Mg-nanomotor
N2(g) + 2OH-(aq) + 4H2O(l) surface: (A) Ti coated Mg micromotor. EDX
spectroscopy images of an Mg micromotor
illustrating the distribution of (B) Titanium
Nano-rockets
and (C) Magnesium. (D) Propulsion images of
Mg micromotor showing the circular
2NO2
N2(g) + 2OH-(aq) + 4H2O(l)trajectory in 2 % NaCl solution and 1% Triton
X-100.
b
2NO2-
0.2
H2
0.1
c
0.0
400
500
/nm
600
a: Std. Nitrite solution
b: PEDOT motor (1.41%)
c: Mg Micromotor (92.83%)
Next objective: The use of nano-rockets for
removing organic pollutants from water
Laboratory of Environmental and Applied Electrochemistry – Prof. Carlos A Martinez Huitle (carlosmh@quimica.ufrn.br)
Water
purification
by
electrochemistry
Electrocatalytic materials decorated with nanomaterials for removing
pollutants from water
Aim: Large disk electrodes of Ti/TiO2-nanotubes/PbO2 (65 cm2 of geometrical
area) are successfully synthesized by anodization and electrodeposition
procedures. Characterization of anodes was performed by SEM, EDS, AFM and
electrochemical measurements, aiming towards environmental applications.
PbO2, an electrocatalytic material, promotes the production of strong oxidizing
species (hydroxyl radicals) that can be used for decontamination of water.
Nanomaterials
Zeolites
Oxygen
Silicon or
Aluminum
https://research.chemistry.ohio-state.edu/dutta/group-members/michael-severance/
13
Zeólitas
Shape Selectivity
 Reagent Selectivity
+
14
Zeólitas
Shape Selectivity
 Product Selectivity
CH3OH +
15
Zeólitas
Shape Selectivity
 Transition State Selectivity
16
Nanomaterials
Layered Zeolitic
precursor
MCM-22
Calcination
Delamination
MCM-36
ITQ-2
Pergher, S. B. C.; Corma, A.; Fornés, V.; Quím. Nova 2003, 26, 795.
Pergher, S. B. C.; Corma, A.; Fornés, V.; Acta Scientiarum. Tecnology. 2003, 25, 83.
Corma, A.; Fornes, V.; Pergher, S. B. C.; Patente Mundial WO9717290A1, 1997.
Corma, A.; Fornes, V.; Pergher, S. B. C.; Maesen Th. L.; Buglass, J. G.; Nature 1998, 396, 353.
17
Nanomaterials
MCM-22
LABPEMOL- Laboratório de Peneiras Moleculares
Sibele Pergher
18
Nanomaterials
Volumen Adsorbido (cm 3 /g)
700
ITQ-2
N2 Adsorption Isotherm
600
500
ITQ2-50
400
300
M 36-50
200
M 22-50
M22-50
M36-50
ITQ2-50
100
SBET
(m2/g)
451
810
841
Vtotal
(cm3/g)
0.5239
0.5920
0.9478
VBJH
(cm3/g)
0.1692
0.3159
0.8533
0
0,0 0,1 0,2 0,3 0,4 0,5 0,6 0,7 0,8 0,9 1,0
p/po
150oC
250oC
350oC
Lewis
Brönsted
Lewis
Brönsted
Lewis
Brönsted
MCM-22
15,0
24,9
10,5
20,7
9,0
15,4
ITQ-2
17,4
13,6
16,2
11,8
10,8
4,7
LABPEMOL- Laboratório de Peneiras Moleculares
Sibele Pergher
19
Cracking of n-Decane
14
M22-50
60
M22-50
12
ITQ2-50
M36-50
C5-C9 (%)
Conversión (%)
ITQ2-50
50
40
30
M36-50
10
8
6
20
10
0,3
0,4
0,5
0,6
CAT/OIL
0,7
4
0,8
15 20 25 30 35 40 45 50 55 60
Conversión (%)
40
7
M22-50
M22-50
M36-50
20
Coque (%)
Gases (%)
ITQ2-50
30
Nanomaterials
6
ITQ2-50
5
M36-50
4
3
2
10
1
15 20 25 30 35 40 45 50 55 60
Conversión (%)
15 20 25 30 35 40 45 50 55 60
Conversión (%)
LABPEMOL- Laboratório de Peneiras Moleculares
Sibele Pergher
20
Nanomaterials
Cracking of Gasoil
60
M 22-50
Conversión (%)
ITQ2-50
M 36-50
50
40
30
0,1
0,2
0,3
0,4
0,5
CAT/OIL
0,6
0,7
10
M 22-50
M 22-50
25
ITQ2-50
Gasolina (%)
Diesel (%)
M 36-50
8
ITQ2-50
M 36-50
20
15
6
10
30
35
40
45
50
Conversión (% )
55
60
LABPEMOL- Laboratório de Peneiras Moleculares
Sibele Pergher
30
35
40
45
50
Conversión (% )
55
60
21
Nanomaterials
Cracking of Gasoil
25
M 22-50
M 22-50
4
ITQ2-50
ITQ2-50
M 36-50
Coque (%)
Gases (%)
20
15
10
M 36-50
3
2
1
30
35
40
45
50
Conversión (% )
55
60
LABPEMOL- Laboratório de Peneiras Moleculares
Sibele Pergher
30
35
40
45
50
Conversión (% )
55
60
22
Nanomaterials
Projects in development
 Synthesis, characterization and application of magnetic




nanostructures and of noble metals - Luiz Henrique da S.
Gasparotto
Synthesis and characterization of nanocomposites based on
zeolites and ceramic membranes for its use in catalysis - Sibele
B. C. Pergher
Synthesis of Nanoparticles by Sputtering Deposition in
Lubricants - Salete Martins Alves
Extraction and separation of rare earth minerals of Brazil and its
application in development of metamaterials to high
performance permanent magnets - Jose Humberto de Araujo
Physical properties of nanostructured materials - Luiz Felipe
Cavalcanti Pereira
23
Nanomaterials
Projects in development
 Synthesis and characterization of nanostructured mixed




tantalum and niobium carbide from columbite, doped with
cobalt - Carlson Pereira De Souza
Obtain a new smart and functional textile material for
synthesis, study and application of photosensitive
nanocapsules - Jose Heriberto O. do Nascimento
Nanostructured multifunctional materials: development of
routes for production of Ferromagneto/AlN multilayers Marcio Assolin Correa
Capture of CO2 to Produce Glycerine Carbonate - Carlos
Alberto Paskocimas
Cellulosic Fibers Nanocrystals and Biocomposites - Clovis
de Medeiros Bezerra
24
Thank you
NATAL