Model answer of pathology exam Tamreed Port said Second year 2013-2014 Q1. Give an account about (3x5=15) a) Pathogenesis of cystitis b) the causes of thrombosis c) Major criteria of rheumatic fever A )PATHOGENESIS of cystitis: Various causes A. Urinary stones denude epithelium and expose the basement membrane, allowing bacteria to attach and predisposing to cystitis. B. Bladder outlet obstruction, as in BPH. C. Indwelling catheters D. Infections : Gram-negatives: E. Coli, Proteus, or Grampositives: Staph, Enterococci. B) Causes of thrombosis Causes 1-Endothelial injury 2-Alteration in normal blood flow 3-Hypercoagulability Endothelial injury Injury may occur due to hypertension, bacterial endotoxins, and hyperlipidemia. Alteration in normal blood flow The cellular element flow centrally in the vessel lumen, separated from endothelium by a clear zone of plasma. C ) }Five major criteria of rheumatic fever 1. Erythema (macular skin rash) 2. Chorea (rapid involuntary movement) 3. Carditis – necrosis in the myocardium surrounded by lymphocytes, plasma cells macrophages (Aschoff bodies). 4. Subcutaneous nodules 5. Migratory arthritis ( one joint is affected after the other) Q2. Define :- (2.5x2=5) a) leukemia b) hypertention Leukemia Definition Malignant disease of white blood cells in the bone marrow, the blood and tissues are invaded by malignant leukocytes Hypertension: Definition Persistent elevation of the systolytic and diastolytic blood pressure above 140/90 mm of mercury due to increased peripheral resistance in the arterioles. Q3. Fill the following blanks. (2.5x4=10) a) Pneumonia is classified into lobar and bronchopneumonia b) The causes of chronic viral hepatitis are virus B and virus C c) Vasoactive amines and Arachedonic acid metabolites and Cytokines Are chemical mediators of inflammation d) Cardiogenic, hypovolemic, septic and neurogenic are types of shock Q4. Connect A and B column.(2x5=10) Column B Column A 1. fibroma a- is dissolution 2-is fluid in the peritoneal cavity b-. Furuncl 3. Fate of thrombus c- is swelling 4. Hydroperitonium d-is benign tumor 5. Cardinal sign of inflammation answer of Q 4 1 (d) 2 (e) 3 (a) 4 (b) 5 (c) e-is infected hair follicle f-is malignant tumor Q5.What is the difference between dry and moist gangrene. (10) Difference between dry and moist Gangren Dry Gangrene Moist Gangrene Gradual arterial occlusion Exposed parts ( limbs) Slow putrefaction Tissue mummification Slow spread Marked line of demarcation Self separation may occur Mild toxemia Sudden internal organs ( intestine) rapid putrefaction Tissue edema rapid spread poor line of demarcation Self separation absent severe toxemia Best wishes Prof Dr Tahany shams Pathology department FOM-SCU 01228790821