Faculty of Allied Medical Sciences Organic chemistry (MGOC-101) Supervision: Prof.Dr.Shehata El-Sewedy Dr. Fatma Ahmed Outcomes By the end of this lecture, the students will be able to 1-Recognize physical properties for alcohol 2-Known nomenclature of aliphatic and aromatic alcohol 3- learn preparation of aliphatic and aromatic alcohol 4- known reaction of aliphatic and aromatic alcohol 5-Differentiate between aliphatic and aromatic alcohol 6- Understand the order of acidity Alcohol ROH as function group of alcohol Physical properties Alcohol soluble in polar solvent (H2O) Alcohol have high boiling point due to have intermolecular hydrogen bond So alcohol its boiling point higher than corresponding alkane, ether which have the same number of carbon ROH> R-H> R-O-R Alcohol Alkane ether As number of OH group increase hydrogen bond increase, boiling point increase & viscosity increase. Nomenclature 1-Common name Alkyl name+alcohol 2-IUPAC 1-Select the long continuous chain have OH as parent name (alkane alkanol) 2-Number from side near to OH group to give lowest number (position+alkanol) 3-Substitution its position& name write 4-Priority in numbering of groups -COOH>-CHO>-CO->-OH>alkene>alkyne>R EX: Preparation of alcohol 1-Reduction of carbonyl group 2-By Grignard reagent EX: N.B 3-Oxymercyrcation-Demercurcation of alkene EX: Reaction of alcohol 1-Oxidation of alcohol 2-Esterification EX: Nomenclature Preparation of phenols From halobenzene Reactions of phenols Ether formation Ex. The order of acidity RCOOH ˃ Ar-OH ˃ HOH ˃ R-OH Phenol is more acidic than alcohols because:- Quiz time Complete: Arrange for the order of acidity: R-OH - RCOOH - HOH - Ar-OH Convert: Chlorobenzene Student Question Write the nomenclature for the following compounds Write the chemical formula for the following compounds? Assignments(1) Group A and Group B Applications of glycerol Samar Mostafa- Omnia MosaadEsraa Kamel- Reem khaledShrouk Essam Oxidation of Alcohols Ahmad Rada Kamel – Ahmad Mohamad Abd El Salam- Ahmad El SaidAhmad Alaa Uses of Amines Sara Lotfy- Shimaa Saied – Esraa Sameh-Ahmad Shadra-Ibrahim El-Habet- Ibrahim El Said Effect of Acetophenone on health Aya Ibrahim – Shreen Hassan – Mohamad Ahmad Torky- Mohamad Montaser- Doaa Sabri Nucleophilic reaction Someya Mostafa – Maram Ahmad – Esraa Mahmoud Electrophilic reaction Youssef AboBakr – Mina Melad – Omar Gamal Kamal Assignments(2) Group A and Group B Applications of acetone Hanan Ahmad Zaid -Alfa Magdi - Alaa Kamal Anani – Asmaa Mohamad El-Awadi- Sara Ali Abd El-Latif- Alaa Emad El Din – Eisha Youssef Uses of Anisole Hagar Saeed – Shrouk Abd El-Aziz – Mona Ashraf Ramadan – Nahed Atia –Mai Mahmoud-Haidy Mahmoud – Walaa Ebada Applications of Salicylic acid in industry Khaled Eid- Sameh Raafat- Bishoy ShanodaSobhy Sabry-Ahmad Saeed Shehata-Abd El Rahman Abd El Aziz-Ahmad Zian-Mohamad Waheed Effect of Formaldehyde on health Aya Ibrahim – Shreen Hassan – Mohamad Ahmad Torky- Mohamad Montaser- Doaa Sabri-Asmaa Gamal-Mahmoud Ezzat-Shady – Rewan Mohamad-Ahmad-Taha Mohamad Nasri - Eisha Ali Assignments(3) Group A and Group B Intermolecular Hydrogen bond Hend Nazmy – Heba Waheed – Hagar Adel -Eman Gamal Acidity of Alcohols Mostafa Ahmad Shata – Abd El Rahman AliMohamad Magdi- Motasem Abd El-Aal Applications of Benzoic acid Mohamad Mahmoud Awad-Marwa AhmadSara Emad –Mariam Hamdy Organic compounds in food Marina Maged-Nourhan Emad-Engy RoshdyMadonna Micheal-JosianIsaq-Merna Farag Allah-Christin Magdi-Verona RomaniMakarious Maher-Mena Malak Assignments(4) Group A and Group B Effect of Phenol on health Eman Gamal- Mona Ashraf Kamal- Fahd Abd El Salam-Mohamad Montaser-Wasal Mohamad Cancer Kholod El-Said – Riham Hassan – Esraa Hafez-Asmaa Basha –Asmaa Mohamad Hassan-Dina Nassem Uses of Toluene Ibrahim Abd El Aatti-John Micheal-Bishoy Sadeek InfraRed spectroscopy Mariam Thrwat- Kyrillos Rafaat – Mina Kabeel-Fadi Abd El Salam Recommended textbooks: 1-Raymond Chang. Chemistry: An introduction to organic chemistry. 10th ed. 2009 2008 2-Zumdehl. Organic Chemistry; study guide and solution manual. 2008