Interpretation of Biosignals in Biomedical Engineering

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Department of Computer Engineering
ati.ttu.ee
Faculty of Information Technology
and
interdisciplinary research in the areas of electronic
systems and biomedical engineering
Gert Jervan
Tallinn University of Technology
Department of Computer Engineering
© Gert Jervan
Mission

The Faculty of Information Technology has evolved
from the Faculty of Electrical Engineering founded in
1965

The main objective is:

to carry out the university objectives

in the faculty´s domain study, research and development

in the fields of
• computer science, informatics and software engineering,
• computer and systems engineering,
• radio and communication engineering,
• electronics, and
• other fields of information technology all over the university
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© Gert Jervan
Departments
• Computer Engineering
• Computer Science
• Informatics
• Computer Control
• Electronics
• Radio and Communication Engineering
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© Gert Jervan
Study domain, degree programmes

3+2 system:

Bachelor degree: 3 years
180 ECTS

Master degree: 2 years
120 ECTS

Doctoral degree: 4 years

Bachelor & Master degrees

ECTS will be applied in
2009
240 ECTS

Business Information Technology

Computer and Systems Engineering

Electronics and Bionics

Informatics

Telecommunication
PhD degree

Information and Communication Technology
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© Gert Jervan
Students - 2008
PhD; 110
Bachelor; 1500
Master; 600
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© Gert Jervan
Graduates - 2008
PhD; 4
Bachelor; 160
Master; 130
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© Gert Jervan
Academic Staff


Teaching staff:

20 professors (average age 53 years)

19 ass. professors (average age 57 years)

14 university lecturers (average age 43 years)

27 teaching assistants (average age 33 years)
Research staff:

18 senior researchers (average age 43 years)

24 researchers (average age 33 years)
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© Gert Jervan
Collaboration in Estonia


Estonian Association of ITT

feedback from industrial community to improve teaching

direct collaboration in curricula development

student placements in the industry
R&D in cooperation with industry

With more than 15-20 companies in Estonia
• AS Artec Group (the 10th place at Central European Technology
Fast 50 program)
• National Semiconductors Estonia
• ARSmicro (Fincitec)
• Ericsson Estonia
• EMT (telecom), Elcoteq (EMS), LDI (diagnostic instr.)...
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© Gert Jervan
International Cooperation

International cooperation is going on with world
leading industrial companies like St. Jude Medical,
Boston Scientific, National Semiconductor, Analog
Devices, TDI Inc, Göpel Electronic,
STMicroelectronics, AerieLogic, TransEda, ...

And with very many universities:

Helsinki University of Technology (Finland), Royal Institute of
Technology Stockholm (Sweden), Linköping Univeristy
(Sweden), Darmstadt University of Technology (Germany),
University of Saarland (Germany), Turku University
(Finland), TIMA Labs (France), University of Torino (Italy),
University of Verona (Italy), PUCRS (Brazil), ...
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© Gert Jervan
Spin-Off Companies

Spin-off companies developed by the faculty staff
members

Ahero OÜ – development and production of sonars

Comptuur OÜ – development of information systems

IB Krates OÜ – industrial control and information systems



Rantelon OÜ – design and production of radioelectronics
systems
Smartimplant OÜ – biomedical development projects
Testonica Lab OÜ – testing and test generation for electronic
systems
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© Gert Jervan
Infrastructure Development Project

"Embedded Systems and Components“
• Time span: 2006-2008
• Funded from the European Structural Funds
• Total investment ca 4 M EUR
• 101 workplaces, of what 54 new and 47 modernized

New laboratories:
• MINAKO - Laboratory of Micro- and Nanoelectronic
Components
• SIE - Laboratory of Communicative Electronics
• ASSA - Laboratory of Synthesis and Analysis of
Embedded Systems
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© Gert Jervan
CEBE

Centre for Integrated Electronic Systems and
Biomedical Engineering - CEBE

CEBE is composed of three research groups:




Design of Reliable Embedded Systems (RES)
TTÜ, Dept. of Computer Engineering, Raimund Ubar
Electronic Components and Subsystems for Mission
Critical Embedded Systems (EMBEL)
TTÜ, Dept. of Electronics, Mart Min
Interpretation of Biosignals in Biomedical Engineering
(BME)
TTÜ, Technomedicum, Ivo Fridolin
About 80 reseachers and PhD students
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© Gert Jervan
CEBE ülevaade
CENTRE FOR INTEGRATED ELECTRONIC SYSTEMS
AND BIOMEDICAL ENGINEERING (CEBE)
EU
EU Projects
Projects
Bilateral
Bilateral
projects
projects
Baselab
SIE
Baselab
MINAKO
Baselab
ASSA
Design
Design of
of Reliable
Reliable Embedded
Embedded Systems
Systems (RES)
(RES)
ELIKO
ELIKO
Industrial
Industrial
Partners
Partners
Electronic
Electronic Components
Components and
and Subsystems
Subsystems for
for
Mission
Mission Critical
Critical Embedded
Embedded Systems
Systems (EMBEL)
(EMBEL)
Graduate
Graduate
school
school
Interpretation
Interpretation of
of Biosignals
Biosignals in
in Biomedical
Biomedical Engineering
Engineering (BME)
(BME)
Infrastructure based on R&D infrastructure development
project “Embedded Systems and Components (SARS)”
Based on: Estonian Excellence Centre of Dependable Computing (2003-2007),
TUT’s Centre of Excellence in Electronics and Bionics-EBIT (2002-2007),
TUT’s Centre of Excellence in Biomedical Engineering (2002-2007)
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© Gert Jervan
CEBE International Cooperation

Europrojects (7)







FP5: Verification and Validation of Embedded System Design
Workbench - VERTIGO (2006-2008)
FP6: Knowledge Environment for Interacting Robot Swarms ROBOSWARM (2006-2009)
FP7: Smart Museum: Cultural Heritage Knowledge Exchange
Platform - SMARTMUSEUM (2008-2010)
FP7: Centre of Research Excellence in Dependable
Embedded Systems - CREDES (2008-2010)
FP7: Integration of Fluidic and Electric Microscaled Principles
- INFLUEMP (2007-2010)
EUREKA: ITEA2 project D-MINT with ABB, DAIMLER, VTT
OLAF: Study on the Euro Coin calibration procedure for
obtaining certified reference standards - EUROCOIN
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© Gert Jervan
Embedded Systems
Embedded
systems
General purpose systems
Microprocessor
market shares
99%
1%
Communication-intensive
heterogeneous
real-time systems
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© Gert Jervan
RES: Research Fields

Dependable Digital Systems
(ATI, Raimund Ubar)

Design and Synthesis

Verification and Debugging

Testing and Fault Diagnosis

Design for Dependability
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© Gert Jervan
Power Density
Power Density (W/cm2)
10000
Rocket
Nozzle
1000
Nuclear
Reactor
100
8086
Hot Plate
10 4004
P6
8008 8085
Pentium® proc
386
286
486
8080
1
1970
1980
1990
Year
2000
Courtesy,
Intel
2010
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© Gert Jervan
Thermal map: 1.5 GHz Itanium-2
Cache
Temp
(oC)
Execution
core
120oC
[Source: Intel Corporation and Prof. V. Oklobdzija]
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© Gert Jervan
The result...
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© Gert Jervan
EMBEL: Research Fields
Personal and body area electronics
We make electronics
disappear, embedding it
into your clothes and bed,
under the skin,
into your body and organs –
lungs, heart, brain, etc...
and helping so your healing
and making your life more enjoyable
when your body organs
are injured or weary of life
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© Gert Jervan
EMBEL: Research Fields
Body area sensor network
•
BAN – Body Area Network
•
PAN – Personal Area Network
•
Conductive communication
through tissue as via “liquid wire”
•
Near-field wireless communications (400 MHz, MICS)

Impedance of the communication media (body) against
the electromagnetic field
characterizes properties of
the body

Tissue impedance exposes as
a biosensing parameter
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© Gert Jervan
BME: Research Fields
TensioTrace – Device for continuous beatto-beat blood pressure measurements.
The theoretical background of the method
based on study results of Department of
Biomedical Engineering and Estonian
Institute of Cardiology.
Advances of the method:
1) Simple measurement procedure;
2) Short measurement time (output for every
heart beat);
3) Fully non-invasive and patient-friendly
method (because we use light).
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© Gert Jervan
BME: Research Fields

Brain research:
understanding and protection of
the brain

Interpretation of the EEG signal:
• New methods of EEG analysis sensitive
to reveal small alterations in the signal
hidden in natural variability of the EEG;
• Effect of modulated microwave radiation
on the brain – harmful or healing;
• EEG-based parameters for distinction of
alterations characteristic for mental
disorder (depression)
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© Gert Jervan
BME: Research Fields

Prediction of sudden cardiac death (SD)




European Union - 3000 cases per day/1,1 million per
year
USA – 1500 cases per day/500 000 per year
Professional help is still possible during the first 4-5
min after SD appearance
Prediction is important!
• Parameters: Non-invasive VR parameters, physiological,
biochemical and radioimmunological investigations and assessing
QT interval parameters
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© Gert Jervan
BME: Research Fields
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Absorbance 285nm
Smoothed Absorbance 285nm
A(t) = A 0 *e Sa*t
ln(Absorbance 285nm)
2
1
Time, min
0
0
60
120
180
240
ln[A(t)] = Sa*t + ln(A 0 )
-1
The clinical experiments at the Department of Dialysis
and Nephrology, North-Estonian Medical Centre
DiaSens,
LDIAMON AS
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Department of Computer Engineering
ati.ttu.ee
Thank You!
Gert Jervan
Tallinn University of Technology
Department of Computer Engineering
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