Genetics Student Review

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Genetics

Jessica Garr, Amanda Melair, Ashley Regan, Jake Young,

Giovanni Marrero

What is Genetics? What are terms associated with Genetics?

Genetics is the study of heredity, or the branch of biology that deals with heredity and genetic variations.

Genotype: What is genetically expressed in an organis

Phenotype:What is physically expressed in an organism

Homozygous: Identical pairs of genes for any given characteristic

Heterozygous: Different pairs of genes for any given characteristic

Dominant: The trait that is physically expressed

Recessive: The trait that is present but not shown

Mitosis & Meiosis

Mitosis has 4 phases:

Prophase

PREPARE

Chromosomes are visible

Lose nucleus

Metaphase

MIDDLE

Chromosomes line up in the middle

Anaphase

AWAY

Chromosomes move towards the poles

Telophase

TWO NUCLEUS

Nucleus split and reappears

They are identical cells

Body cells

Diploid cells

Meiosis goes through 2 processes:

Prophase l

Crossing over

Protiens of chromatids break off and attach to the adjacent chromosomes on the homologous chromosomes

Metaphase l

Anaphase l

Homologous chromosomes seperate

Telophase l

Prophase ll

Mertaphase ll

Anaphase ll

Sister chromatids seperate

Telophase ll

4 haploid cells result

They are similar cells

Sex cells

Haploid cells

Stages of Meiosis l and ll http://thumb7.shutterstock.com/display

_pic_with_logo/848740/116607409/stock

-vector-vector-diagram-of-the-meiosisphases-116607409.jpg

STages of Mitosis

• http://www.google.com/search?q=mitosis&safe=active&source=lnms&tbm=isch&sa=X&ei=XgubU9GfEJGOyAS2_

IKYDA&sqi=2&ved=0CAYQ_AUoAQ&biw=1301&bih=620#facrc=_&imgdii=_&imgrc=nhZbmMsNUC3FM%253A%3BUhqCAF-wnFwS9M%3Bhttp%253A%252F%252Fdiffervs.com%252Fwpcontent%252Fuploads%252F2013%252F08%252Fmitosis-vsmeiosis.jpeg%3Bhttp%253A%252F%252Fdiffervs.com%252Fdiscover-difference-mitosismeiosis%252F%3B495%3B420\

Mitosis Video

• http://video.mit.edu/watch/lego-animation-of-mitosis-with-descriptivetitles-3077/

DNA

Stands for Deoxyribonucleic Acid

Primary Function: to store and transmit the genetic information that tells cells whcih protiens to make and when to make them

DNA is an organic compound made up or repeating subunits called nucleotides.

Nucleotides have 3 parts:

Sugar molecule

Deoxyribose

Phosphate Group

2 types of Nitrogen Bases

Purines

Phosphorus

Oxygen

Nitrogen Bases

Adenine (A)

Cytosine (C)

Guanine (G)

Thymine(T)

Have 2 rings

Adenine(A)

Guanine(G)

Pyrimdines

Have 1 ring

VIdeo: https://answersingenesis.org/genetics/ / •

Cytosine(C)

Thymine(T)

en.wikipedia.org

DNA Cont.

Base Pairings:

Cytosine bonds with Guaning (C-G)

Adenine bonds with Thymine (A-T)

James Watson and Francis Crick built the 3D model or the double helix

2 nucleotide strands wrap around eachother to form a double spiral

Enzymes involved in DNA replication:

DNA Helicase

Unwind and unzip the DNA

Binding Proteins

Hold open the replication fork

DNA Primase

Lay down the start and stop primers for the new strand

DNA Polymerase

Lays down one new nucleotide at a time

DNA Ligase

The glue that holds the new DNA strand together

The Enzymes involved in DNA replictation

Stands for Ribonucleic Acid

Responsible forthe movement of genetic information from the DNA

RNA

in the nucleus to the site of protien synthesis in the cytosol

A single sranded nucleic acid made up of repeating units

Sugar molecule is ribose

Thymine(T) relaced with

URACIL(U)

A strand of RNA http://chemistry.tutorvista.com/bio chemistry/nucleic-acids.html

RNA cont.

3 Forms of RNA

Messenger RNA (mRNA)

Function:

Carries genetic info from the nucleus to the ribosome

Transfer RNA (tRNA)

Function:

Binds to specific amino acids and helps form polypeptide chains (proteins)

Ribosomal RNA (rRNA)

Function:

Makes up the ribosomes where proteins are made

Protein synthesis

Protein Synthesis- The production of proteins

The amount and kind of proteins produced in a cell determines the structure and function of the cell

2 Steps in Protein Synthesis

Transcription:

Makes mRNA from DNA

Transcribe- to copy

Translation:

• mRNA leaves the nucleus through pores in the nuclear membrane

• mRNA then migrates to a ribosome in the cytosol, the site of protein synthesis http://sciencevogel.wikispaces.com/file/ view/Protein%20Synthesis%20diagram.

png/493016480/390x301/Protein%20Syn thesis%20diagram.png

Mutations/Disorders

Genetic Disorders:

Genetic Traits and Disorders-

Genes that control human traits can be mutated and then inherited by offspring

Mutations-

Definition- A change in DNA sequence that affects genetic info

The result of some mutations are gentic disorders

Inheritance- There are 4 main ways genetic disorders are passed....

Single Gene Disorder

The problem traits controlled by a single gene and are passed in a dominant/recessive manner

Multifactoral Disorders

These disorders result from mutations in multiple genes

These disorders are difficult to study and treat

EX. Alzheimer's Disease, Hypothyroidism

Karyotype showing the genetic disorder of Down

Syndrome http://learn.genetics.utah.edu/content/d isorders/chromosomal/down/images/tris omy21_karyotype.jpg

Mutations/Disorders continued

Inheritance cont.

Chromosomal Abnormality

Entire chromosomes or large segments of chromosomes are missing, duplicated, or otherwise altered

Nondisjunction-

Failure of a chromosome to seperate from its homologue during meiosis

One gamete receives an extra copy of a chromosome and the other gamete lacks the chromosome entirely

Scientisits can use karyotypes to identify disorders caused by chromosomal abnormalities

X-Linked Disorders

Disorders in which the mutations or errors are in genes found on the X chromosomes

Ex.- Hemophilia, Muscular Dystrophy

Review Questions

What is the full name for DNA?

Deoxyribonucleic Acid

What two organelles can DNA be found in? Nucleus, Mitochandria

What is the shape of DNA?

Double Helix

What is a Gene?

A sequence of DNA passed on to offspring

What are the two purines found in DNA? Adenine, Guanine

What are the two phases of protein synthesis? Transcription, Translation

What are the four types of chromosomal mutations?

What is the gene that is expressed called?

What is a mutation?

Answers

What is the full name for DNA?

Deoxyribonucleic Acid

What two organelles can DNA be found in? Nucleus, Mitochandria

What is the shape of DNA?

Double Helix

What is a Gene?

A sequence of DNA passed on to offspring

What are the two purines found in DNA? Adenine, Guanine

What are the two phases of protein synthesis? Transcription, Translation

What are the four types of chromosomal mutations? Deletions, Duplication, Insertion,

Translocation

What is the gene that is expressed called?

Dominant

What is a mutation? A change in the DNA sequence that effects genetic info

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