01.11.10
Lecture 1: An Introduction to Cell Biology
Professors
Cell Biology half:
Steve Rogers
422 Fordham Hall
Srogers@bio.unc.edu
Development half:
Jason Reed
104 Coker Hall
Jreed@email.unc.edu
Office hours by
appointment
Office hours: TBA
Teaching Assistants
Alli McMullen
allison_mcmullen@med.unc.edu
Kyle Grode
kylegrode@gmail.com
Office hours: TBA
Course format
• Lectures: MWF 11 to 11:50 AM
• Recitations begin January 19th and attendance
is required. Students will turn in weekly problem
set and TAs will go over the answers.
Class Website
• http://www.bio.unc.edu/Courses/2010Spring/Biol205006/
• Lecture notes will be posted the day before the lecture
(.PDFfile)
• Problem sets will be posted on Friday afternoon and
will be due the following week in recitation
Required Textbooks
• Essential Cell Biology, 3rd edition, by Alberts et al.
(first half of the course)
• Principles of Development, 2nd edition, by Wolpert
(second half of the course)
Grading Policies
• 4 non-cumulative exams count towards 92% of the
final grade. Weekly problem sets count towards 8% of
final grade.
• Tests will cover information in lectures, recitations, and
reading assignments
• Make-up exams will be given only for valid reasons
(medical excuses)
• Regrade requests must be submitted prior to the next
exam
Policies
• UNC-CH honor code. All exams are to be taken
without books notes, or other people and you will
be asked to sign a pledge to that effect.
• Please turn off your cell phones during class
Advising for Biology Majors
•
Please go to the Biology Department website
http://www.bio.unc.edu/Undergraduate/
to find information about:
• Degree Programs
•
•
•
•
Biology General Education Requirements
Bachelor of Arts in Biology
Bachelor of Science in Biology
Minor in Biology
• Advising-How to find a Biology adviser
•
•
Undergraduate Advising
Abbey Fellow-Dr. Elaine Yeh yeh@email.unc.edu
• Resources
•
•
•
•
Biology Majors' Manual
Study Abroad
Registrar's Online Services
• Research Opportunities
•
•
•
•
Undergraduate Research
Biology Honors Program
Funding & Outreach
Office of Undergraduate Research
What is cell Biology?
What is cell Biology?
Divisions in the biological sciences are
based on degrees of “complexity”
Biochemistry & Biophysics: study of the
structures and behaviors of molecules
Microbiology: study of prokaryotic cells and
viruses
Cell Biology: study of the structure and
function of eukaryotic cells
QuickTime™ and a
Sorenson Video 3 decompressor
are needed to see this picture.
QuickTime™ and a
Sorenson Video 3 decompressor
are needed to see this picture.
Developmental Biology: study of how communities
of cells form tissues, organs, and build an
organism
QuickTime™ and a
Cinepak decompressor
are needed to see this picture.
Anatomy & Physiology: study of the structures
and functions of tissues and organs
Zoology & Plant Biology: study of the
organisms
Ecology: study of how organisms interact with
each other and with their environments
Levels of Biological Complexity
1. Biochemistry & Biophysics
2. Microbiology
3. Cell Biology
4. Developmental Biology
5. Anatomy & Physiology
6. Zoology & Plant Biology
7. Ecology
Understanding cell biology is important to
understand the basis for disease
• Hypercholesterolemia (defective uptake of lipoproteins)
• Cystic fibrosis (misfolding of key protein)
• Hypertension (defective cell-cell adhesion in the kidney)
• Congenital heart defects (errors in cell migration during development)
• Myscular dystrophy (defective attachment of the plasma membrane to the
cytoskeleton)
• Lysosomal storage disease (defective intracellular transport of enzymes)
• Food-borne illness (Salmonella, E. coli)
• Cancer (errors in cell division, migration, cell polarity, growth, etc)
• Ageing
• All disease states are caused at the cellular level
Understanding cell biology is important to
make informed decisions on social issues
•
•
•
•
•
•
Genetic engineering of foods
Biotechnology
Organ growth in culture
Stem cell research
Forensic sciences
Archaeology