ERT 207-Analytical Chemistry
Lecturers:
Dr. Saleha Shamsudin (Coordinator)
Assoc. Prof. Dr. Mohamed Zulkali bin Mohamed
Daud
Course synopsis:
This course introduces and discusses the basic
principle of analytical chemistry that covers data
analysis and interpretation. Basic statistics and the
utilization of statistics are applied in most of the
analytical methods. In this course students are
able to apply classical analytical methods such
as gravimetry and titrimetry as well as applying
modern methods in analytical chemistry such as
chromatographic and spectroscopic technique.
Learning Outcomes:
At the end of the course, students are expected to be:
1. Ability to calculate and perform the correct statistical method
for data analytical and to remember the steps in quantitative
analysis.
2. Ability to classify and use separation techniques and
gravimetric methods for mass determination.
3. Ability to differentiate and to calculate concentration of
analytes of various titrimetric methods (acid-base,
complexation, redox, and precipitation).
4. Ability to apply the chromatography principles and to
interpret and calculate peak height for concentration
determination.
5. Ability to understand the spectroscopic principles and to
interpret and calculate concentration.
List of experiments:
1.The potentiometric titration of an acid.
2.Determination of water hardness by
complexometric titration.
3.Determination of limonene concentration in citrus
fruit extracts by gas chromatography.
4.Interpretation of spectra of an unknown sample
using Fourier transform-infrared (FTIR) spectroscopy.
5.Determination of active drug substance in a
pharmaceutical formulation using ultraviolet and
visible spectrometry (uv/vis).
Learning approach:
Lecture
: 42 hours (60 %)
Laboratory
: 20 hours (28.6 %)
Tutorial
: 8 hours (11.4 %)
Evaluation contribution:
•Peperiksaan / Examination
•Mid Term Examination 1
= 10 %
•Mid Term Examination 2
= 10 %
•Final Examination
= 50 %
: 70 %
•Penilaian berterusan / Continual assessment : 30 %
•Laboratories
= 15 %
Assignments / Quizzes
= 15 %
List of text books and references :
Buku Teks/ Text book(s):
•Gary D. Christian (2004). Analytical Chemistry. 6th Edition.
Publisher: John Wiley & Sons, Inc.
Buku Rujukan/ Reference books:
•David Harvey (2000). Modern Analytical Chemistry. Publisher:
McGraw-Hill
•D. Keely and P. J. Haines (2002). Analytical Chemistry. Publisher:
Oxford: Bios Scientific
D. A. Skoog, D. M. West and F. J. Holler (1996). Fundamentals of
Analytical Chemistry. Publisher: Saunders College Publication.
Minggu/
Week
Week 1
(9/09 –
13/09)
Kandungan Kursus / Course Contents
(Panduan/Guidelines)
INTRODUCTION TO ANALYTICAL CHEMISTRY
Tugasan
Pensyara
Bacaan/
h/Lecture
Reading
r
Assignment
Chapter 1
Dr.
Saleha
Week 2 – 3 UTILIZATION OF STATISTICS IN DATA ANALYSIS
(16/09 –
Chapter 1
Identify the significant testing. Calculate the T
27/09)
test and Q test.
Dr.
Saleha
Explain qualitative and quantitative. Repeat
the steps in quantitative analysis or unit
operation in analytical chemistry.
BASIC STATISTICS
Define accuracy and precision, remember
ways of describing accuracy and precision,
types of errors, understand the concept of
significant figures, standard deviation.
CALIBRATION CURVE
Interpret slope, intercept, coefficient
correlation and coefficient of determination
(r2)
CHEMICAL EQUILIBRIUM
Discuss the concept of chemical reaction:
the rate concept, type of equilibria, Le
Chatelier’s principle. Effects of temperature,
pressure and concentration on equilibria.
Week 4 - 5 ACID-BASE EQUILIBRIUM
Dr.
(30/9 –
Chapter 2
Saleha
Repeat acids and bases theories, acid base
11/10)
equilibria in water, pH scale. Discuss weak
acids and bases, calculate the pH of salt of
weak acids and bases. Discuss buffers.
Introduce strong acids and strong bases,
Apply detection of end point, indicators.
Discuss weak base versus strong acid.
Week 6
Cuti Pertengahan Semester / Mid-semester Break
(14/10 18/10)
PREPARING SAMPLES FOR ANALYSIS
Discuss type of separation techniques.
Week 7 - 8 Classify separation techniques based on
(21/10 – chemical or physical properties. Classify
1/11)
separation based on a partitioning between
phases. Calculate partition coefficients and
distribution ratios.
Chapter 3
Dr.
Saleha
CLASSICAL METHODS IN TECHNIQUES OF
ANALYTICAL CHEMISTRY: TITRIMETRIC
METHODS OF ANALYSIS
Week 9-10 Explain acid-base, redox, complexation and
precipitation titrimetry. Discuss on the
(4/11 –
reactions involved. Calculate the
15/11)
quantitative and qualitative application of
acid-base, redox, complexation,
precipitation titrimetry. List other application
titrimetry.
MODERN METHODS IN TECHNIQUES OF
ANALYTICAL CHEMISTRY:
CHROMATOGRAPHIC AND ELECTROPHORETIC
METHODS
Assoc. Prof
Dr.
Chapter Mohamed
4
Zulkali bin
Mohamed
Daud
Introduce principles of chromatography and
Assoc. Prof
Dr.
Week 11 – electrophoresis. Discuss gas chromatography
and
applications.
Calculate
quantitative
and
13
Chapter Mohamed
(18/11 – qualitative applications of gas
5
Zulkali bin
chromatography (GC). Discuss high29/11)
Mohamed
performance liquid chromatography (HPLC)
Daud
and applications. Calculate quantitative and
qualitative applications of high-performance
liquid chromatography (HPLC). Discuss
electrophoresis and its applications in protein
and DNA analysis.
MODERN METHODS IN TECHNIQUES OF
ANALYTICAL CHEMISTRY: SPECTROSCOPIC
TECHNIQUES
Explain the properties of electromagnetic
Assoc.
radiation and relate with spectroscopic
Prof Dr.
Week 14 - techniques. Introduce techniques on
Mohame
spectroscopy based on absorption
15
Chapter 6 d Zulkali
(ultraviolet-visible and Fourier transform(2/12 –
bin
infrared spectroscopy (FT-IR) and atomic
13/12)
Mohame
absorption spectroscopy (AAS). Demonstrate
d Daud
qualitative and quantitative applications of
UV/visible, infrared and atomic absorption
spectroscopic techniques in biological
analysis. Calculate concentration using
spectroscopic techniques.
Week 16
(16/12–
Minggu Ulangkaji / Revision Weeks
20/01)
Week 17 20
Peperiksaan Akhir Semester/ Final Examination
(23/12 –
10/01)
LABORATORY PLAN
Group
1
A1, A2 & A3
A4, A5 & A6
Hari Malaysia
Exp 1
Exp 5
Exp 5
Exp 1
Exp 1
7
9
14
15
16
Exp 1
Exp 5
Exp 4
Tutorial 3
Tutorial 3
Exp 4
Exp 2
Exp 3
Tutorial 4
Tutorial 4
11
13
Tutorial 2
Tutorial 2
8
12
Exp 5
Mid Semester Break
6
10
Tutorial 1
Tutorial 1
4
5
B4, B5 & B6
Introduction to Analytical Chemistry
2
3
B1, B2 & B3
Exp 3
Exp 2
Exp 2
Exp 3
Tutorial 5
Tutorial 5
Exp 3
Tutorial 6
Lab Test
Study Week
Exp 2
LAB GROUPS
A1
AINA MADIA BINTI RAZALI
NUR HAZIRAH BINTI MOHD YUSOFF
SITI NURSHAMILA BINTI ZAMZURY
MOHAMAD AMIN BIN AWANG TEH @
ISMAIL
LIM SHIN YUAN
ANG LI WEI
A2
MUHAMMAD FAIZ BIN ZAINOL BAHRI
NUR AMIRAH BINTI MAHFOD
SAW WAN LING
NUR ASYILAH AKMAL BINTI ABDULLAH
MOH LAI KUAN
ANG KIAN THING
B1
CHOO YEE CHING
NUR AMALINA BINTI ABDULLAH SANI
SITI KHADIJAH BINTI MASOR @ IBRAHIM
KWAN SIN YEN
ASSADUL HAQ ALI HAMIDI
BOO CHIE HANG
B2
NORHIDAYAH BINTI MOHAMAD
NORHAIZA NADIA BINTI HALIB @
YAHAYA
ONG LI JING
MOHD SHAFIQ BIN MD ZIN
ANNIEBELL A/P STANLEY LOURDES
L.BENEDICT
JASMINE FONG JIE MIN
A3
B3
NURUL NABILLATUL MUNIFA BINTI R. AZMI SITI NABIHAH BINTI AB MAJID
PUA CHEE WEE
TAN HUAN YIH
RAYMOND LIM HUNG TAT
PUTRI NOOR NATASHA BINTI CHE YEO
MEGAT
NUR ATHIRAH AWATIF BINTI ABDUL
NADYA ORSELA ANDICO
RAHMAN
CHUAH SIN YE
LAU KIA KIAN
ADZDZIN SHAFWAN BIN ADLAN
CHONG WAIN KET
A4
YUHANEES SYUHADAH BINTI MALIHAN
NUR AMALINA BINTI MUHAMAD ZAIDI
NUR AMIRAH ASIFA RAISHA BINTI ZAHARI
NABILAH BINTI HUSAIN
MOHAMAD ADIB BIN EDRIS
CHEE CHEAU YEE
WONG JING RUI
NURUL NADIAH BINTI MOHAMAD NIZAM
NUR SYAZWANI BINTI ISMAIL
MUHAMMAD SYAFIQ BIN SANI
LEONG YONG YOU
CHEONG XIAN ZHI
A5
VIVIAN LEE JIAQIAN
ONG YU LIAN
NURUL SHAKIRA BINTI JOHARI
NOR SYAHIDA BINTI ISMAIL
GOOI MING YAN
SHARIFAH SABIRAH BINTI SYED HAMZAH
B5
TENGKU INTAN NADZRAH
SITI AISYAH BINTI MOHD RAMLI
NUR HIDAYU BINTI MISRAN
NG ZHANG JIN
MUHAMAD IKRAM BIN JAMALUDIN
AMIRA NASYRAH BINTI MOHD HUSIN
A6
SITI RABAAH BINTI HAMZAH
TAN SIEW YEN
NURAINI BINTI ABDULLAH
NABILAH AFIQAH BINTI SUHAIMI
MUN HUI SIN
B4
B6
ONG XIN SHI
NURULFARAHANA BINTI HARUN
NOR ATIQAH BINTI JUSRIL
NG PEY XUAN
ANIS USMANI
Important Note: Your attendance to
lecture / tutorial / laboratory is
compulsory. If absent without
reason, the student can not sit for
the final examination.