GI BOARD REVIEW December 16, 2010 INFANT NUTRITION Breast milk ideal Supplements: Vitamin D 400IU/day Fluoride (exclusive breast feeding may require Fe supplements after several months of age) VLBW infants Higher Ca, Phos, vitamin requirements QUESTION 1 You are seeing a healthy 6 month old infant for a well visit. The mother is concerned that the baby is not taking in enough calories. What is the required cal/kg/day for this child? A. 70 B. 100 C. 50 D. 125 E. 80 MALNUTRITION Explore diet and eating habits Formula Type, quantity, how it is mixed Older Children Food intake, preferences, avoidances Plot BMI EXTREME MALNUTRITION Marasmus Caloric deficiency Emaciation Hypothermia and bradycardia late Kwashiorkor Protein deficiency Edema Hepatomegaly, AMS Marasmic-kwashiorkor QUESTION 2 Which of the following electrolyte abnormalities may be seen in refeeding syndrome? A. B. C. D. E. Hyperkalemia Hypercalcemia Hypophosphatemia Hypoglycemia Hypermagnesemia NUTRITION Low weight for height Diminished height (and wt) for age Acute Failure to Thrive Chronic undernutrition Refeeding syndrome Hypophosphatemia Hypokalemia Hypomagnesemia Hypocalcemia Glucose intolerance VITAMIN DEFICIENCIES B1 (THIAMINE) Beri Beri Mental confusion Peripheral paralysis Muscle weakness Tachycardia Cardiomegaly B2 (RIBOFLAVIN) Stomatitis (angular) Anemia Dermatitis (seborrheic) Infants on prolonged phototherapy at risk B3 (NIACIN) 3D’s of B3 Dermatitis Diarrhea Dementia Glossitis Toxicity results in vasodilation B9 (FOLATE) Large tongue and macrocytic anemia Neural tube defects When folate given for macrocytic anemia, may mask B12 deficiency B12 (CYANOCOBALAMIN) Macrocytic anemia Pernicious anemia Poor absorption (decreased intrinsic factor) VIT C (ASCORBIC ACID) Scurvy Bleeding gums Leg tenderness Poor wound healing Toxicity Nephrocalcinosis Hemolysis in G6PD FAT SOLUBLE VITAMINS ADEK VIT A (RETINOL) Most common cause of childhood blindness worldwide Eye Findings Dry eyes (xerophthalmia) Night blindness Bitot spots (shiny gray triangular conjunctival lesions) Follicular hyperkeratosis Intoxication Pseudotumor cerebri VIT E (TOCOPHEROL) Hemolytic anemia in preemies Neuro changes Neuropathies Absent DTRs Ataxia Weakness VIT K (PHYLLOQUINONE) Hemorrhagic disease of the newborn Breast fed babies Factors 2,7,9,10 Prolonged PT GASTROENTEROLOGY HELICOBACTER PYLORI Endoscopic findings Antral gastritis Nodularity of antrum Duodenal ulcers Treatment: “Triple Therapy” Antibiotics X2wks, PPI X4wks Amoxicillin, clarithromycin, PPI Amoxicillin, metronidazole, PPI Clarithromycin, metronidazole, PPI PANCREATITIS Causes: Gallstones in adults Trauma and systemic diseases (HUS) in children Biliary tract disease Congenital anomalies Drugs Organ transplantation Idiopathic Infectious Metabolic Post-op Malignancy INTUSSUSCEPTION Age 3mos – 5yrs Older children usually have lead point Meckel’s HSP (ileo-ileal) Classic Triad: colicky abd pain, vomiting, current jelly stools: 30% May present with lethargy or seizure Air contrast or barium enema Recurrence in 10% CONSTIPATION Delay or difficulty passing stool for >2wks resulting in discomfort to patient Usually functional Overflow incontenence or encopresis Chronic distal fecal impaction Stretching of rectal wall Relaxation of internal anal sphincter Bladder dysfunction with UTI QUESTION 3 You are seeing a 2 year old child that has had chronic constipation since infancy. You suspect Hirschprung disease. Which of the following tests is necessary for the confirmation of diagnosis? A. B. C. D. E. Rectal suction biopsy Unprepped barium enema Prepped barium enema Endoscopy Upper GI with small bowel follow through HIRSCHSPRUNG DISEASE Constipation from early infancy Unprepped barium enema Transition zone Rectal bx for ganglion cells VOMITING PYLORIC STENOSIS Narrowing of pyloric channel Unknown etiology Secondary to hypertrophy of musculature Erythromycin Presentation 3-5 weeks Forceful, projectile, nonbilious vomiting Persistent hunger Constipation Dehydration Unconjugated hyperbili PYLORIC STENOSIS Physical Exam Peristaltic wave Olive Lab finding Hypokalemic, hypochloremic metabolic alkalosis Diagnosis US Near 100% sensitivity and specificity PYLORIC STENOSIS Diagnosis US UGI Near 100% sensitivity and specificity “string sign” Treatment Pyloromyotomy QUESTION 4 The diagnostic approach to a child with symptoms typical of uncomplicated GER is: A. B. C. D. E. Barium swallow and pH probe Barium swallow No investigation pH probe Subspecialty consultation REFLUX GER GERD Passage of contents into the esophagus Symptoms and complications Symptoms Vomiting Poor weight gain Substernal chest pain Abdominal pain Dysphagia Esophagitis Respiratory disorders REFLUX GER Common Usually self-limited Disappears by 1 to 2 years of age GERD Growth failure Aspiration Esophagitis Hemorrhage Apnea Sandifer syndrome RARE REFLUX Diagnosis Based clinically UGI Does not diagnose reflux! Anatomic abnormalities pH probe Correlates symptoms with episodes Esophagoscopy Assess esophageal injury REFLUX Therapy Frequent small feedings Upright position? Prone?? Thickened feeds 1 tablespoon/ounce H2 blockers PPIs Prokinetics Controversial Nissen INTESTINAL MALROTATION AND VOLVULUS Incomplete rotation of the intestine during embryonic life Presentation Sudden onset Bilious emesis Abdominal pain Bilious emesis is a surgical emergency until proven otherwise INTESTINAL MALROTATION AND VOLVULUS Studies Plain film Paucity of air in lower abdomen UGI Gold standard “corkscrew” Small intestine on right C-loop does not cross midline Treatment Surgical Emergency DIARRHEA QUESTION 5 The mother of a 2-year-old complains that her son has frequent, watery, foul-smelling stools with visible food particles that has been occurring for >2 weeks. The child appears well on physical exam and his weight is at the 50%ile. Stool analysis reveals a pH of 5 and no evidence of fat malabsorption. Of the following the MOST appropriate management plan for this infant is to: A. Avoid all fresh fruits and vegetables B. Avoid all lactose-containing dairy products C. Begin a high-fat, low-carbohydrate diet D. Keep a food diary E. Increase the total daily fluid intake DIARRHEA Usually acute and infectious Chronic >2 weeks Most commonly postinfectious or dietary History Small bowel Watery and free of mucus Infectious or inflammatory Blood and/or mucus DIARRHEA Stool Examination Reducing substances Stool pH Infection or inflammation Ova and parasites Malabsorption Fecal leukocytes Low (<5) in carbohydrate maldigestion and malabsorption Fat Unabsorbed sugar Parasitic pathogens Stool culture Bacterial pathogens E.COLI DIARRHEA Enterotoxigenic E.coli Traveler’s diarrhea Thrives in environment (food and water) Incubation 1-3 days Large outbreaks in US Watery diarrhea, voluminous, may resemble cholera Self limited Fluid therapy Prophylaxis not necessary in healthy children If asked to choose: Bactrim E.COLI DIARRHEA Enteroinvasive E.coli Closely related to Shigella Clinical course nearly identical to Shigella E.COLI DIARRHEA Enterohemorrhagic E.coli (O157:H7) Undercooked ground beef Reported in apple cider/ raw vegetables Summer months Shiga toxin-positive Bloody diarrhea Hemolytic uremic syndrome PATHOGENESIS Shigella Person-to-person transmission Incubation up to 7 days Carrier state up to 4wks salmonella Killed rapidly by acidity Animal transmission Common source outbreaks Eggs/poultry Incubation 24hrs Longer carrier state CLINICAL MANIFESTATIONS Shigella salmonella Leukemoid reaction Neuro symptoms HUS Mild leukocytosis Focal infections Reactive arthritis Osteo in Sickle Cell Dz HLA-B27 Typhoid fever Salmonella typhi Fever, H/A, abd pain, muscle aches, rose spots TREATMENT Shigella Treat with antibiotics salmonella Ceftriaxone Cipro Infants <3mos Immune compromised Bacteremia Decreased carrier state Treat ONLY high risk Ceftriaxone or ampicillin Beware resistance!! Increased carrier state ROSE SPOTS OF TYPHOID FEVER CAMPYLOBACTER Undercooked poultry, unpasteurized milk Second most common documented foodborne illnesss in US Watery or hemorrhagic Sequelae Reactive arthritis Guillian-barre YERSINIA ENTEROCOLITICA Mimics appendicitis Peak in winter Contaminated food and water Undercooked pork (chitterlings) May have insidious onset May last up to 3 wks Prolonged shedding 2-3 mos Low mortality Sequelae Reactive arthritis Erythema nodosum VIBRO CHOLERAE Most common Asia, Africa, S.America Endemic along gulf coast Contaminated seafood Reports following Katrina and Rita Incubation 1-3 days Sudden and severe dehydration Rice water stools If untreated, 50-70%mortality within 1-2 days Treatment Aggressive rehydration Abx as adjunct DIARRHEA Acute infectious Bacterial C. Diff Bloody diarrhea Abdominal pain Vomiting Test for toxin Recent antibiotics Treat with flagyl unless <6 months Viral Rotavirus is leading cause worldwide Low grade fever, vomiting, large loose watery stools Adeno is second DIARRHEA AND FEEDING AAP Recs… Continue age appropriate diet Pedialyte if dehydrated 2% glucose and 90mEq NaCl Avoid ONLY foods high in fat and simple sugars NO BRAT: “unnecessary starvation” Do not use antidiarrheal medications