Jenna Paterno KNH 413 Professor Matuszak 2-11-14 Case Study 14: Peptic Ulcer Resulting In Gastrectomy 1. List all the food items that may contribute to GG’s condition and explain why. Frozen dinners: frozen dinners are usually very high in sodium, which over time has proven to damage the stomach lining http://www.healthassist.net/food/side-effects/side-effects.shtml Fried Foods: foods high in fat are sometimes hard on the stomach to digest. Fat and cholesterol can also increase stomach acid causing the stomach lining to be even more irritated http://www.healthassist.net/food/side-effects/side-effects.shtml Black Coffee, Chocolate Bars, and Coke: Caffeinated drinks and food trigger the production of stomach acid. As the amount of stomach acid increases or is regular at a higher level the more likely the lining of the stomach will be destroyed. Rum: alcohol and ulcers may not necessarily be linked, but the association of heavy drinking and ulcers have seen throughout research http://www.nlm.nih.gov/medlineplus/ency/article/000206.htm Milk: Milk has been recommended to consume to help treat PUD, however, it has been learned that the consumption of milk increases gastrin and pepsin secretion. (Nelms, 363). http://medicalcenter.osu.edu/patientcare/healthcare_services/digestive_disorders/p eptic_ulcers/Pages/index.aspx 2. List any additional oral intake that may have contributed to GG’s condition and explain why. Tums/ Antacids: Antacids are commonly taken to help reduce heartburn and indigestion, which is caused by stomach acid. GG sometimes feels relief after taking Tums because at the moment it is reducing the amount of stomach acid being produced by the digestive system. Aspirin: GG is currently taking aspirin to reveal her headaches, however this is causing more harm than good for her. Aspirin is known to relive pain, but it can cause damage to the stomach lining. In GG’s case, this would cause her ulcer to worsen. http://www.nlm.nih.gov/medlineplus/ency/article/000206.htm Smoking: Smoking increases the risk of getting an infection called H. Pylori, which is considered a bacteria infection causing a peptic ulcer. However, GG already has been considered to have a peptic ulcer, therefore, she should stop smoking because it will slow down the healing processes of the sore in the lining of her stomach. http://medicalcenter.osu.edu/patientcare/healthcare_services/digestive_disorders/p eptic_ulcers/Pages/index.aspx 3. List the non-oral stimulants that could contribute to GG’s condition and what she could do to change them. GG is currently very stressed with all the different life changes she is currently going through. She is recently separated from her husband, but after being with him for several years where he has supported her and their 4 year old son she has realized she needs to go back to school to be able to get a job to currently support herself and her son. After trying to balance her schoolwork and raising her son acting as both a mother and a father, her son was recently diagnosed with ADHD, which can be emotional and physical stress in the beginning when trying to learn how to overcome his difficulties. Some changes that GG could consider to help her overcome her health problems is to make a weekly schedule that works for her, her son, and her mother who is helping babysit GG’s son while she is at school. GG should cut down on the amount of hours she is taking in the beginning to have a smoother transition into school, while trying to balance her family life also. Taking less credits will help her organize a schedule that will be easy to follow and hopefully be less stressful for her. 4. List the symptoms of GG’s gastritis. GG has mentioned that she gets easily upset and often has to take antacids for burning stomach. However, in the last month the pain she has been experiencing has been much worse and more often. The pain occurs 30 minutes after eating and is taking antacids to deal with the pain. The other night she woke up from sever pain in her right side that continued up into her chest. After taking TUMS and drinking some milk the pain slowly went away, and she was able to go back to sleep. The next morning she woke up with sever gastric pain again and tried taking TUMS and drinking milk, but the pain never went away. This is when she decided to come to urgent care center. 5. Was a bland diet necessary? Explain and list the principles of the diet plan that you think GG should follow. A bland diet is not necessary for GG. In her situation there are different foods and beverages she should eliminate from her diet such as foods high in fat; for example fired foods, caffeinated beverages; for example strong black coffee and coke, foods that contain black and red pepper, and also eliminate the consumption of alcohol. Some other foods GG should avoid are those that she feels bothers her after consumer, or where she needs to take TUMS to help cope with her pain. She should consult with a Registered Dietitian to help her create a large list of foods she can still consume and different easy meal options she can prepare for her and her son on those busy days as an alternative to frozen meals. (Nelms, pg 363) 6. What is the mechanism of action of the following medications GG is receiving: Carafate, Alternagel, and Pepcid? Carafate (Sucralfate): The mechanism of action is not 100 % understood, but the actions are considered to be important for its beneficial effects. - It binds to the surface of the ulcers and coats it to protect the ulcer from further injury - It directly inhibits pepsin, which is an enzyme that breaks apart proteins, in the presence of stomach acid. - It binds bile salts coming from the liver protecting the stomach lining from injury, which can be caused by the bile acids It may increase prostaglandin production, which are known to protect the lining of the stomach http://www.medicinenet.com/sucralfate/article.htm Alternagel: used to treat symptoms of too much stomach acid. http://www.medicinenet.com/aluminum_hydroxide_suspension-oral/article.htm Pepcid: Pepcid is an oral drug that blocks the production of acid by acid-producing cells in the stomach. H2- blockers inhibit the action of histamine on the cells, which reduces the production of acid. http://www.medicinenet.com/famotidine/article.htm 7. List the nutrient-drug interactions that are associated with these medications. Carafate: avoid taking other medications within two hours of taking Carafate. Avoid using antacids unless recommended by your doctor, some antacids make it harder for Carafate to work within your system. http://www.medicinenet.com/sucralfate/article.htm Alternagel: avoid citrate due to dangerous results. Consume larger amounts of phosphorus, folic acid, and calcium because absorbing these nutrients can be difficult http://www.healthcentral.com/static/pp/pdf_guides/nutrient.pdf) Pepcid: possibl risk for certain difficienies such as iron, zinc, folic acid, and vitamin B12. http://www.healthcentral.com/static/pp/pdf_guides/nutrient.pdf 8. What are GG’s IBW and percent IBW? Hight: 5 feet 2 inches Weight: 98 lbs IBW: 5 ft= 100 lbs + 5 lbs for every inch after =100 lbs + 5 (2 inches) = 110 pounds % IBW: (ABW/ IBW) x 100 = (98 lbs/ 110 lbs) x 100 = (.891) x 100 = 89 % 9. Estimate her daily energy needs using the Harris-Benedict equation and appropriate stress factor. Harris-Benedict equation: 655+ (9.56 x W (kg)) + (1.85 x h (cm))– (4.68 x age) = 655+ (9.56 x 44.5kg) + (1.85 x 157.48cm) – (4.68x27) = 655 + (425.42) + (291.34) – (126. 36) = 1245 kcals = 1245 X 1.0 = 1245 kcals = 1245 X 1.5 = 1868 kcals I used a range for GG’s stress level of 1.0 to 1.4 because of her infection and her activity level. A range of calories she should consume would be 1250- 1900. I would recommend her to consume more toward the higher amount of calories considering she is slightly under her IBW. Her body also needs the extra calories to help her body adequately heal her ulcer. 10 What might be the cause of LUQ pain along with her usual pain? (Hint: consider the enzymes that are elevated.) GG’s left upper quadrant pain can come from a variety of different factors. However, it did mention that she started to heavily drink again which would cause elevated liver enzymes in her system. This could be a reason as to why GG is feeling pain in the LUQ. 11. In the second lab values, glu, BUN, Cr, ser alb, Na, K, Cl, hgb, and hct all dropped. This probably means that GG was: a. Bleeding b. Eating poorly in the hospital c. Dehydrated when the first labs were drawn d. Over hydrated when the second set of labs were drawn, A drop in lab values can indicate that she is over hydrated due to her pervious labs indicating she needed an IV. 12. In the second set of lab values, serum amylase, AST, and ALT all dropped. This probably means that: a. Enezymes were elevated due to alcohol b. Her medications caused them to drop c. GG was dehydrated when the first labs were drawn d. GG was over hydrated when the second set of labs was drawn The first time GG’s labs were taken were within 24 hours of her drinking. This could have caused these values to be elevated due to the fact that the kidney was working to clean out toxins. When the labs were taken a second time GG hadn’t consumed alcohol in a longer span of time allowing for those different values to drop. 13. Refer to the two lab tables again, and note that two days after admission, GG’s Alk Phos and CPK remained essentially unchanged. Why? a. These enezymes are not affected by alcohol or hydration b. Her medications caused them to drop c. Dehydration when the first labs were drawn d. Over hydrated when the second set of labs was drawn 14. What diagnostic test(s) (not lab values) indicates that GG has an ulcer? GG had an esophagogastroduodenoscopy, which is a test to examine the lining of the esophagus, stomach, and first part of the small intestine. In GG’s situation this revealed the gastric superior to the pyloric sphincter with an ulcer on the dorsal wall of the duodenum. GG’s stool also tested positive for blood. http://www.nlm.nih.gov/medlineplus/ency/article/003888.htm 15. Briefly sketch the anatomical position where GG’s ulcer can be found. 16. Define: H2 Antagonist: a drug that reduces or inhibits the secretion of gastric acid by binding competitively with histamine to H2 receptors on cell membranes. http://www.merriam-webster.com/medical/h2%20antagonist Proton Pump Inhibitor: a group of drugs that reduce the secretion of gastric acid. http://medical-dictionary.thefreedictionary.com/proton+pump+inhibitors 17. What is the mechanism of action of the following medications GG is receiving: Nexium: Esomeprazole is a proton pump inhibiort that suppresses gastric acid secretion by inhibition of H+/K+- ATPase in the gastric parietal cell. The proton pump blocks the final step in acid production, which reduces the gastric acidity. http://www.rxlist.com/nexium-drug/clinical-pharmacology.htm Amoxicillin: amoxicillin acts by inhbiting the synthesis of bacterial cell walls. It inhibits the cross-link between the linear peptidoglycan polymer chains that make up a major component of the cell walls of gram-positive and gram-negative bacteria. https://www.princeton.edu/~achaney/tmve/wiki100k/docs/Amoxicillin.html Clarithromycin: prevents the growth of bacteria by interfiering with the synthesis of the protein. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a692005.html 18. GG was not receiving counsel at the time the major bleeding started. If you had the opportunity to counsel GG just before the bleeding, in what areas would you feel competent to counsel her and in what areas would you refer her to someone else? Investigate the agencies in your area that are available to provide assistance to someone like GG. I would feel comfortable counseling GG in areas of her life that relate to her diet and her health. Since her ulcer is a major concern I would help her with a list of foods that she felt she should can could consumer and also help her think of healthy and fun meals for her and her son to make. I would help her think of a list of foods high in protein to help her bulk up her calories and get the right nutrition to help her ulcer to correctly heal and continue leading a healthy life. However, in regards to talking to someone about her life struggles and overcoming working while taking care of her son and going through her divorce I would recommend a therapist to her so she is able to talk and get some advice on how to go about these different life changes. I would also recommend her going to a physician that she feels comfortable meeting with and reaching out to when she starts to feel ill. 19. What is the significance of the dark stools? The dark stool signifies that there is blood in her stool. This is showing that there is bleeding in the upper gastrointestional tract, such as the stomach. This indicates that there is most likely another ulcer. http://www.mayoclinic.org/stool-color/expert-answers/faq-20058080 20. Give the pathophysiology for the cause of the following abnormal values: BUN, NH3, and WBC. BUN: blood, urine, and nitrogen test are done to reveal important information about a patients kidneys and how well they are working. It does this by measuring the amount of nitrogen in your blood. Higher levels of nitrogen may indicate that your kidneys are not working properly, which can lead to other health altercations. In GG’s situation, her BUN levels are elevated, indicating that her kidneys might not be working as well as they should be. http://www.mayoclinic.org/tests-procedures/blood-ureanitrogen/basics/definition/prc-20020239 WBC: white blood cells are considered disease-fighting cells. In GG’s situation she has an elevated level of WBC, which indicates that she currently has an illness that her body is working to fight off. http://www.mayoclinic.org/symptoms/high-white-blood-cell-count/basics/whento-see-doctor/sym-20050611 21. GG was probably dehydrated on admission since she had been drinking. This means that some of her values were probably higher/lower (circle one) than indicated. Since GG was drinking she was most likely dehydrated, which would alter her lab values. This indicates that some of her values were probably higher than indicated. 22. After admission GG received packed cells and IV fluids. How would that affect the next set of lab values? Since GG received packed cells and IV fluid, her next set of lab values should be more normal than before. Since she is dehydrated her lab values may be higher than normal and if she is over hydrated her lab values may be lower than the normal amount. 23. Define the follow: Packed Cells: a blood product consisting of concentrated cells, most of the plasma having been removed. Given to a patient who needs red blood cells without increased fluid volume. http://medical-dictionary.thefreedictionary.com/packed+cells Abdominal Tap: a procedure used to remove the fluid from the area between the stomach wall an the spine (abdominal cavity). http://www.nlm.nih.gov/medlineplus/ency/article/003896.htm Perforated Ulcer: an ulcer that bursts through the stomach wall and leaks food and gastric juices into the abdominal cavity. http://www.collinsdictionary.com/dictionary/english/perforated-ulcer Fistula: an abnormal connection between an organ, vessel, or intestine and another structure. Usually the result of injury or surgery. http://www.nlm.nih.gov/medlineplus/ency/article/002365.htm Exploratory Laparotomy: an operation into the peritoneal cavity where the surgeon examines all surfaces for a lesion Billroth II: the surgical resection of the pylorus to the stomach, followed by closure of the cut ends of the duodenum and gastrojejunostomy. http://medical-dictionary.thefreedictionary.com/Billroth's+operation+II Vagotomy: severing of the vagus; often a component of gastric surgery (Nelms, pg G-26) 24. Sketch Billroth I. 25. Compare Billroth I to Billroth II as to anatomical changes as well as to dietary changes, if any. Billroth I: is also considered gastroduodenostomy, a partial gastrectomy or pyloroplasty is performed with a reconstruction that consists of an anastomosis of the proximal end of the duodenum to the distal end of the stomach. Billroth II: also considered gastrojejunostomy is a partial gastrectomy with a reconstruction that consists of an anastomosis of the proximal end of the jejunum to the distal end of the stomach. With both of these surgeries nutrient absorption is a concern due to the fact that parts of the stomach are being removed that are responsible for absorbing certain nutrients. (Nelms, pg 364) 26. Calculate GG’s energy and protein needs. Weight: 98 lbs / 2.2 kg= 44.5 kg Height: 5 ft. 2 in =(5 feet x 12 in = 60 in + 2 in = 62 in/ .3937 cm = 157.48 cm EER= 10 X w(kg) + 6.25 (H cm) - 5 (age)- 161 = 10 x ( 44.5 kg) + 6.25 (157.48 cm) – 5 (27)-161 = 445 + 984.25 – 135 -161 = 1133.25 = 1133.25 x 1.2 =1,359.9 GG has a stress factor of 1.2 because she currently had surgery and she is going to have to learn how to adapt to a new diet. I would recommend trying to get a max of 1,400 kcals a day to allow her to get an adequate start to a healthy recovery. Protein: 1.0-1.5 g protein/kg 1.0 g protein X 44.5 kg= 44.5 grams of protein per day 1.5 g protein X 44.5 kg= 66.8 grams of protein per day 45-70 grams of protein The adequate amount of protein for an individual is 1.0-1.5 g protein/ kg. The range for GG is 45 grams to 70 grams of protein. Since she is currently recovering from surgery I would recommend for her to have a greater bulk of protein to help her properly recover. (Nelms, pg 61) 27. List the principles of a postgastrectomy diet and briefly describe the scientific basis for each principle. - Adequate energy and protein intake to ensure appropriate healing and recovery postop o If progression to solid foods does not proceed successfully appropriate nutrient support may recommended - Slow progression of solid food to prevent onset of early and late dumping syndrome. o Avoid all simple sugars in the beginning - Lactose intolerant and dairy products should be avoided - Slowly progress to 5-6 small meals each day - Consume liquids 30 minutes to 1 hour after solid food - Lie down after eating - Addition of functional fibers to delay gastric emptying and assist with treatment of diarrhea. - Prevent the development of nutrient deficiencies o Liquid multivitamins and mineral supplements should be initiated to meet DRI o Vitamin B12 injections are initiated if extent of gastric surgery warents this intervention - Provide nutrition education that will promote optimal nutritional intake and minimize symptoms of malabsorption. (Nelms, 366) 28. Is it possible that GG’s diet will ever change or do you believe she will be on a postgastrectomy diet for the rest of her life? Explain your answer. I feel that if GG is currently on a postgastrectomy diet and continues following an adequate plan she will hopefully be able to change her diet to what she would prefer. She still needs to continue with the small portioned meals throughout the day and monitor her fluid intake. I would not recommend her to go back to her old habits and would make a list of foods she should continue to avoid to prevent future complications. Work Cited Eisner MD, T. (n.d.). Retrieved from http://www.nlm.nih.gov/medlineplus/ency/article/003888.htm Glover. (n.d.). Retrieved from http://www.healthassist.net/food/side-effects/sideeffects.shtml High white blood cell count. (n.d.). Retrieved from http://www.mayoclinic.org/symptoms/high-white-blood-cell-count/basics/whento-see-doctor/sym-20050611 Longstreth, G. (n.d.). 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