Faculty of Medicine Ain Shams University Postgraduate Studies Medical Doctorate in Histgology درجة الدكتوراه فى علم األنسجة و الخلية Program Code: HI700 Program Guide and Logbook 2 Candidate Curriculum vitae [Name] Please attach your recent photo [telephone no] [mobile no] [mailing address] [email address] [postcode] Experience [organization] [your present job title] [start date] [location] [responsibilities] [organization] [previous job title] [start and end date] [location] photo here. 3 [responsibilities] [organization] [previous job title] [start and end date] [location] [responsibilities] Education [certificates] [start and end date] [school or college] 4 Training [any other training that will be useful in your job] Date of Registration First semester _______________________ Second semester _______________________ Third semester _______________________ Fourth semester _______________________ Fifth semester _______________________ Sixth semester _______________________ 5 TABLE OF CONTENTS: Page I – Welcome Statement II - Mission Statement III – Senior supervisor and affiliated departments and Hospitals IV – Program specifications 1 - Basic Information 2 - Professional Information 3 – Academic standards 4 - Curriculum structure and contents 5 - Program courses: 6. Program admission requirements: 7. Regulation for progression and program completion 8. Appendix: course specification 1. Histology 2. Tissue culture 3. Cytogenetics 4. Immunology 5. Molecular biology. V - General information VI – Your log book 1 - Introduction 2 - Supervisors 3 - Tables for training records 4 – Log book preview VII - Head of department approval for the exam entry Detachable forms VIII – Thesis follow up IX - Evaluation forms 6 I – Welcome Statement: The Department of Histology welcomes you to Doctorate degree of Science in Histology. As a department we are committed to medical student education and continuously strive to improve your educational experience. This handbook presents information guide and logbook activity of the Medical Doctorate degree in Histology administered by the Histology department, Faculty of Medicine, Ain Shams University. II - Mission Statement: The mission of the Faculty of Medicine, Ain Shams University is • The preparation of a competent graduate, who is able to compete on both national and regional levels, capable of life long learning, training and tutoring, while adhering to the codes of practice of medical health services and ethics. • The college as well, seeks continuous development of programs and courses. It also enhances expansion of applied scientific research and health programs for community services and environmental development. . The mission of this degree is to prepare a professionally trained researcher and lifelong tutor capable of following standards of scientific teaching and ethics, with professional managerial and technical skills in his specialty. III – Senior Supervisor and Affilated Departments and Hospitals Senior Supervisor Prof. ------------------------------------------------------------------------------------------E-mail: Affilated Departments and Hospitals Histology Department, Faculty of Medicine, Ain Shams University. IV – Program Specifications A- Basic Information 7 1. Program title: Doctorate Degree of Science in Histology 2. Program type: Single Double Multiple 3. Faculty Faculty of Medicine, Ain Shams University. 4. Department Histology. 5. Assistant co-ordinator ……………………………………………………… 6. Co-ordinator ………………………………………………………. 7. Last date of program approval: 30/7/2009 B- Professional Information: 1. Program aims: Preparation of a well qualified lecturer, mastering accurate and up-to-date knowledge in his specialty. Furthermore, the candidate should be monitoring professional level of histological skills following ethical standards. 2. Intended learning outcomes (ILOs): a. Knowledge and understanding: By the end of the program the candidate will be able to: a1 – Describe the structure of the cell and different tissues of the body using light and electron microscopes. a2 – Identify the structure of all systems of the body. a3- Recognize basic knowledge of immunohistochemical, cytogenetic, molecular biological, and statistical sciences. a4- Select the proper microtechniques suitable for histological, immunohistochemical, cytogenetic, and tissue culture to identify different tissues of the body. b. Intellectual capabilities: By the end of the program the candidate will be able to: b1- Correlate the structure to the function of different tissues of the body. 8 b2 – Compare/contrast the structure of different tissues of the body; using different microtechniques. b3– Interpret the light and ultrastrcture of different body tissues. b 4- Choose proper techniques to identify different body tissues. c. Professional and practical skills: By the end of the program the candidate will be able to: c1- Prepare tissues’ paraffin blocks, ultrathin resin sections and slides propely. c2 Stain different body tissues using different techniques. c3 Identify different tissue structure using light and electron microsopes. d. General and transferable skills: By the end of the program the candidate will be able to: d1 – Present a power point presentation. d2 – Prepare a joint discussion paper. d3 – Use e-learning for self study. 3. Academic standards: (Benchmarks) Academic reference standards guided by Georgetown University School of Medicine (SOM). som.georgetown.edu/prospectivestudents/ 4. Curriculum structure and contents: 4a- Program duration: 6 semesters (minimum 3years). 5.1- Compulsory Code number Course title No of hours Lect. Lab. Exer. HI7001 Histology 150hs 300hs 480hs 5.2- Elective- one is required Code number Course title E7009 E7010 E7011 E7012 Tissue culture Cytogenetics Immunology Molecular biology No of hours Lect. Lab. 15 hs 30 hs 15 hs 30 hs 15 hs 30 hs 15 hs 30 hs Exer. - 6. Program admission requirements: -: يشترط لقيد الطالب للحصول على درجة الدكتوراه:)7( المادة 9 -1أن يكونن اصالوعل دوج الووج تيرصليوماد ووت صوص و تيمى ووم أد ااواس تيروونت تبهصهواج تيرم وودج وص صو دوج صمبدتوصت تيااتهوج -9 .تيوايا اااس تيجصصعصت تير ديج أد دج الج صعص يج ي ص -2.صنت قج ل ج تيعرو تيدهنم دص صايف تيماايب داهم عك تبل زو داهمافصء تيريمناتت تيربدن وج وت تيرد و يدااتهج يراو خرس تيراو دج تبق نل اتهاج دج تبق قت -10 0 )2تيمفود خنل تصم وصن تيجوزء تينوص ت .ديركو أن يومد تيمواايب يونفس ج تاا تيريمشفاصت أد تيردتكز تيعدراج تيرعمراو ص تيكداوج عوا أهومافصء تيشوددا تيموج ت وا ص تبقيصم تيرىم ج. 7. Regulation for progression and program completion مادة ( :)8يمد تيميجا ياالصت تياكمناته صدتا ج تيعصم :تبديج ص أدل ينيان امج آخد أغيبس دتينص اوج ص أدل ن رتد امج آخد ييرتد 0 مادة ( :)9تنزع تيااتهج ج ك دا صم لصصعج دج اتهاا صاو كو صن روص خريوج شود تهوتن ص ل .يتوات تالدل ج أدل أكمن د ديتات تينص ج ج صن ف تدتيد .صع تنظاد د يومد تيميوجا يدف و تيااتهوج قتو تهوتن ا صو اتيمو تيريجدج .دالينتغج أن يزيا تيعبء تيااتهج ج تيف تيرقداتت خعل تهتن ا ص اتيج تيف اتهج الافج صكنف يراو هومج تهوص اع . دوج تالقو تينتاا و تيااتهوج عوا اهومافصء تيشوددا ايوب تيرقوداتت 6هوص صت صعمرواو .ديجونز يدبصيوب تعواي صي و ا تد تالفوص ج ) .كروص يجونز يو تال يو ص خوعل هم تهص اع ص تاا تيرقدتات دن تاميص اتهتص ل ا . مادة ( :)17صاو تيااتهج يد نل دج تياكمناته هومج دالعالونن رو دت ل هوو ونل اتهواج) يجموصز خعي ود تيبصيوب د صصجوص ل توواايتاص ل صمكوصصعل صيقيود اتقوص ل يديوص صت تيرعمروواو تيرنفو ج صيتوص تيىووصصس دييومن ج خعي ووص تيربدن صن ج كماب صمص عج تب شبج دال ييرح ي واخنل تمصم وصن قتو اهومافصء العالوج أا وصع تيربدون صنو ص تييص صت تيرعمراو. مادة ( :)18صاو تيااتهج ت تيجزء تبدل يدواكمناته ان دلوا و اتهوت دتاوا يجموصز عواه تيبصيوب اصم ص وص ل دال يشمدا تينجصح ا صيكصص يإل مقصل يدااتهج ت تيجزء تينص ت ديشمدا خعي ص تيمواايب حاواس تيريمشوفاصت تيجصصعاج أد تيردتكز تيرعمراو صو تيقيود ديجنوج تيااتهوصت تيعداوص صيكداوج هونتء صيواتخ أد تيىوصا دوج أن يومد اهمكرصل تيااتهج اتقص ل يديص صت تيرعمراو. مااادة ( :)19يقوونم تيوواتار ياالووج تيوواكمناته ميووجا صنفوونع تيدهووصيج صووع تيقاووا يداالووج دال تجوونز صنصقشووج تيدهصيج قت صددا صصا دج تيميجا يداالج دال يى م ي ص الصت. مادة ( :)20يقنم تياتار ياالج تياكمناته حهمافصء صمبدتصت تيجصصعج قت تيميوجا تيدهووصيج قت و خوونل اصم ووصن تيجووزء تينووص ت .دصمبدتووصت تيجصصعووج ووت تي 10 دصمبدتوصت تيكداوج دصنصقشوج وونل دووج ر و ص و تيمنيف و ووت تيدغووج تم جدازيووج صجروونع 550الووج) دصمبدتووصت تيكداووج ووج اروونا داتت صعمروواو ص و يجنووج تيااتهووصت تيعداووص صيكداج ج صجصل تيمىباط دتيااتهصت تيبتاج دتما صء تيبتت أد الماصز اخمتصاتت خصالج ت ا ص تيدجنج. مادة ( :)21تييص صت تيرعمراو يااتهج تياكمناته هو د تيعنن هص ج صن ص هو د العالنن هص ج ترو اتهوم د تالنصء تيرصليماد د يرصا همنن هص ج صعمرواو دوج تبقو ديى وم صن وص خروس شودو هوص ج يكماوب صمص عوج تب شبج دخرس شدو هص ج يددهصيج دهو هص صت دج تبق يدجزء تبدل ان دلا. مادة ( :)22صاو تيقاا ياالج تياكمناته خروس هوننتت ديجونز يرجدوس تيجصصعوج نوصءت ل دوج ادوب صجدوس تيكداوج د عووا صنت ق وج يجنووج تيااتهووصت تيعداووص صيكداووج عووا ادووب صجدووس تيقيوود داهوومنص ت ل ايووج تقووصايد هووننيج ص و لراووع دج تيبصيب تييورصح حفوص ج وصم دتاوا د وا أق وج الروصن هوننتت صو توصايد تيقاوا يد تيرشد ا ونل دوج الج تياكمناته. مادة ( :)23تدمزم تالقيوصم تيرعناوج صبرومدتك صوع أقيوصم تيرونت تيردتتبوج نفوع اصم ص وصت صنفون اج تشور دهووص تيمقاوواد تيرىمدفووج ص و أهووودج انيدووج دق ووادو دصمعووا و تمخماووصاتت ك داخمتووصاتت اكداناكاووج صقننووج تقوواس تير صاتت تيرىمدفج دج أن تشر كدتهج تيرنص ج تفصالا ذيك دتعمرا ص يجنج تيااتهصت تيعداص صيكداج . مادة ( :)24صجرنع الصت تالصم صن تين ص ج يداكمناته 1500الج صن ص 300الج يدجزء تبدل ان دلوا. ديرصا تيا ص تيرعال تيف دج تيمدتكرج رص ينتزس . 400 مادة ( :)25يعقا اصم صن تيادا تبدل ت أكمن د د ن رتد صو كو دصصين ص ك وصم ديعقوا اصم وصن تيوادا تينوص ت وج أ ديو صم. مااادة ( :)26يكوونن تينجووصح ووج صوونت تيوواكمناته عووا تي دتالكداناكج دتيشفنو ك وونل دووج %60صوو الووج تيم ديوودو دتيعردووت دج ااو. Assessment Schedule and Weighing of Assessments: 11 صد نظج :تعص ل الصت تيبصيب اتقص يدنقصا دج تينل تيمصيج: A نقاط 4 : % 90 - 1فأكثر نقاط A- -2من %85حتى أقل من 3.67 : % 90 نقاط B+ - 3من %80حتى أقل من 3.33 : %85 B نقاط - 4من %75حتى أقل من 3.00 : %80 نقاط B- - 5من %70حتى أقل من 2.67 : %75 نقاط C+ - 6من %65حتى أقل من 2.33 : %70 C نقاط -7من %62حتى أقل من 2.00 : %65 نقاط C- - 8من %60حتى أقل من 1.67 : %62 F :صفر - 9أقل من %60 ديمد ايص تيرعال تيف دج )GPAدوج أهوصر صجرونع اصالو فود قوصا كو صقودا صرودد ص ل وج وا هص صت تيرعمراو صقينصص ل دج تييص صت تيرعمراو يدرقداتت تيمج اهو ص تيبصيوب وج تيف و تيااتهوج .كروص يومد ايص تيرعوال تيمدتكروج يدبصيوب )CGPAدوج أهوصر صجرونع اصالو فود تينقوصا تيموج ا و دا وص تيبصيب ج ك صقدا صردد ص ل ج ا هص صت تيرعمراو صقينصص ل دج صجرنع تييص صت تيرعمراو تيكداج. ج اصيوج تيدهون وج صوص و أد صجرن وج صو تيرقوداتت وج تيوا دنم أدتيرصليوماد أد تيواكمناته يومد تم وص و وج دا ج أدل ا ص و قط أصوص اذت تكودا اهون ج تيرص و أد تيرجرن ج قط .ديمد ايص تيمقايد تيفعدج تي س ي ا يب ي نا تينجصح تقايد %60قط تس 1.67قصا تس .)C- Histology course specification University: Ain Shams Faculty: Medicine Course specifications Course specifications Program on which the course is given: Medical Doctorate Degree in Histology Major or minor element of programs: Major Department offering the program: Histology department. Department offering the course: Histology department. Academic Level: MD – 1st till 6th semester Date of specification approval: ………………………….. Code: HI7001 Code: HI7001 Total: 150hs Total: 300hs Total: 480hs A- Basic Information Title: Histology course Title: Histology course Credit Hours: 28 Lecture: 2h/week Practical: 4 hs/week Activities: 8 hs/week Coordinator Histology department 12 B - Professional Information 1- Course Aims: 1Overall aims of the course: The focus of this course is the accurate and up-to-date understanding of the microscopic structure of cells, organs, and systems in the human body and the direct relationship between the morphology (microscopic structure) of such an organ and its function. The systemic histology course is a continuation of the basic course and it will focus on the clinical and physiological aspects of the organs and its microscopic structure as well as the demonstration of the interaction of histology with other basic medical sciences such as human anatomy (Gross), physiology, biochemistry, cell biology, and Pathology. The Course will summarize the applications of basic histology and illustrate the morphological features of organs and systems however; this section has a direct connection between the microscopic structure of the organ and clinical notes about it. 2- Intended Learning Outcomes (ILOs) from the Course: a) Knowledge and understanding: By the end of the course the student should be able to: a1- Identify the microscopic structure of different cells, tissues and organs of the body a2- Recognize the ultrastructure of different cells, tissues and organs of the body a3- Correlate between the structure and function of different cells, tissues and organs of the body b) Intellectual skills: By the end of the course the student should be able to: b1- Integrate basic histological, anatomical, biochemical and physiological knowledge with clinical data b2- Interpret the structural changes in cells to understand the underlying cause for different diseases b3- Retrieve, analyze and interpret the collected information in lectures, library and searching for solving problems related to structural dysfunction c) Professional and practical skills: By the end of the course the student should be able to: c1- Adjust and deal properly with the light microscope c2- Determine the proper magnification for examining the different cells, tissues and organs. 13 c3- Identify and draw the microscopic structure of different cells, tissues and organs provided. d) General and transferable skills: By the end of the course the student should be able to: d1- Respect his colleagues and work properly in a team d2- Be aware with human and animal research ethics d3- Comply with different believes in the community they serve 3- Course content: Topic actually taught Microtechniques Cell and its components Cell membrane Cytoplasmic organelles Cytoplasmic inclusions Cytoskeleton Nucleus Epithelium Connective tissue Cartilage Bone Muscle tissue Nervous tissue Blood Vascular tissue & skin Respiratory system Digestive system and glands Endocrine system Urinary system Male reproductive system Female reproductive system Eye Ear Receptors CNS Teaching and learning methods: Lectures 14 Lectures (2hrs) 3 7 Practical 6 14 5 10 5 10 5 10 5 5 5 6 4 4 4 4 5 10 10 10 12 8 8 8 8 10 8 16 Practical sessions for demonstration of slides of different cells, tissues and organs with discussion 3) Student assessment: MCQ: To assess knowledge and understanding Practical exam: -To assess the ability to identify the structure of different cells, tissues and organs using light microscope. - to assess the practical skills in preparing different histological sections using different techniques for microscopic examination. Essay Qs: To apply histological knowledge in a comprehensive written way to assess the degree of understanding Oral Exam: To assess the ability of students to explain the structure of cells, tissues and organs in a comprehensive oral way Weighting of assessment: o Written exam 800 o Oral exam 150 o Practical exam 450 o Semesters’ assessment 400 o Total 1900 4) List of references: - lecture notes prepared by staff of the department - Essential books - Basic Histology. Text and Atlas 2005. - Functional Histology - Color textbook of Histology. Gartner& Hiatt. - Core text of neuroanatomy - Bloom and Fawcett Histology. A text book of Histology. - Ham’s Histology. -Essential Histology. -Molecular Biology in Medicine. Cox T.M. and Sinclair J. -Principles of Medical Genetics. T. B. Geleherter and F.S. Collins. -Basic Molecular Genetics. R.Shalaby. - Periodicals and web sites:- http://en.wikipedia.org/wiki/Histology www.najah.edu/nnu_portal/file/faculties/.../Histology som.georgetown.edu/73239.html www.visualhistology.com/ 15 II. Elective Courses (only one is required): A. Tissue Culture Course specifications University: Ain Shams Faculty: Medicine Course specification Program on which the course is given: Medical Doctorate Degree in Histology Major or minor element of programs: Minor Department offering the program: Histology department. Department offering the course: Histology department. Academic Level: MD – 2nd, 3rd or 4th semester Date of specification approval: ………………………….. A- Basic Information Title: Tissue Culture Credit Hours: 2 Lecture: 1h/w Practical: 2h/w Coordinator Code: E7009 Total: 15hs Total: 30hs Histology department B - Professional Information 1- Course Aims: Overall aims of the course: The focus of this course is the basic understanding of live cells and tissues outside the body. Moreover it is helpful in isolating the effect of a single moclecule on one type of cell or tissue. 2- Intended Learning Outcomes (ILOs) from the Course: a- Knowledge and understanding By the end of the course the candidate will be able to: a1 – Describe the proper complex solution suitable for growth of different cells and tissues. a2 – Identify parasites, and viruses that grow only within cells. a3 – State anomalies in the number and morphology of chromosomes in a cultured cell during mitotic division. b- Intellectual skills By the end of the course the candidate will be able to: 16 b1- Apply tissue culture for the study of the metabolism of normal and cancerous cells. b2 – Extend tissue culture study in developing new drugs. c- Professional skills By the end of the course the candidate will be able to: c1- Observe the behavior of living cells under the microscope. c2- Reproduce in vitro-experiments which can’t be performed in living animals. c3- Isolate cells. c4- Cultivate cells in a suspension. d- General and transferable skills By the end of the course the candidate will be able to: d1 - Respect his colleagues and work properly in a team. d2- Be aware with human and animal research ethics. d3- Comply with different believes in the community they serve. 3- Course content: Topics L 2hs 2hs 2hs 2hs Cell division (mitosis, meiosis) Tissue Culture Immunogenetics Cloning No. of hours T C/P 1hs 6hs 2hs 9hs 2hs 9hs 2hs 6hs SDL - L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning 4 - Student Assessment Methods 4.1 written exam to assess basic knowledge and understanding. Weighting of assessment Written 100 Total 100 5 -- List of References 5.1- Course Notes (paper and / or electronic) 5.2- Essential Books (Text Books) 1) Culture of animal cells . A manual of basic techniques(fourth edition, Wiley Press,2000) 2) Basic cell culture. Aparctical approach. (IRL Press,2000) 3) Epithelial cell culture Apractical approach. (IRL Press, 2000) 17 4) Stem cell transplantation (Wiley-VCH, 2006) B. Cytogenetics course specification University: Ain Shams Faculty: Medicine Course specification Program on which the course is given: Medical Doctorate Degree in Histology Major or minor element of programs: Minor Department offering the program: Histology department. Department offering the course: Genetics unit, department of pediatrics. Academic Level: MD at any semester Date of specification approval: ………………………….. A- Basic Information Title: Cytogenetics Credit Hours: 2 Lecture: 1h/w Practical: 2h/w Coordinator Code: E7010 Total: 15hs Total: 30hs Genetics unit, department of pediatrics. B - Professional Information 1- Course Aims: Overall aims of the course: The aim of the course is: This course is designed to give students a basic knowledge of the principles of Genetics. It also gives them an idea about genetic anomalies and who they are incorporated in different genetic disorders and inherited diseases. Students will also learn different diagnostic data in order to provide genetic risk assessment and best genetic advice to individuals and their families in an ethical way. 1- Intended learning outcomes (ILOs): aKnowledge and understanding: By the end of this course the student are able to 18 develop an understanding of: a1. Chromosomal disorders and methods used to characterize the underlying chromosomal abnormality. a2. The molecular basis of inherited disease, diagnostic methods which are used to identify the causative mutations in patients or carriers. a3. Treatments and therapy for inherited disease and cancer, including novel therapies such as gene therapy. a4. The principles and practice of population screening programs for inborn errors of metabolism, prenatal identification of pregnancies at risk of chromosomal disorders. a5. The ethical issues which are an inherent part of Medical Genetics. bIntellectual skills: By the end of this course the student should be able to: b1. Identify children with suspected genetic condition and to direct them to the proper investigation. cProfessional and practical skills By the end of this course the student should be able to: c1. Apply their knowledge base in Medical Genetics in using clues from pedigree, family history and other information to suggest likely inheritance patterns and / or diagnoses. c2. Select the diagnostic or screening methods which will be most appropriate and informative in a given clinical situation whilst taking into account referring them to a geneticist. dGeneral and Transferable/key skills By the end of this course the student should be able to: d1. Acquire time management skills to accomplish individual designated tasks by a given date; d2. Write scientific report and get oral presentation skills. d3. Critically use of online databases and e-journals; Course Contents: L: Lecture, C/P: Clinical or Practical and SDL: Self directed learning Topic Ba sic ge ne tic s L 2 Gene structure and gene function 19 No. of hours C/P SDL 4 2 4 2 2 4 4 2 4 2 4 Immunogenetics: HLA system 3 6 Management of genetic diseases Diagnos tic genetics Organization and structure of chromosomes, karyotype, nomenclature and interpretation of abnormal karyotypes and chromosomal aberrations Mutations and teratogens Pedigree construction, Patterns of inheritance: traditional patterns & non-traditional patterns of inheritance. 1. Molecular Diagnostic Techniques. 2. Cytogenetic Diagnostic Techniques. 3. Biochemical Diagnostic Techniques. 1. Dietary therapy: restriction – supplementation 2. Drug therapy 3. Transplantation therapy: cell - tissue - organ 4. Stem cell therapy 5. Surgical intervention 6. Gene therapy 4- Student Assessment Methods 4.1- Short essay to assess knowledge. 4.2- MCQs to assess knowledge. Weighing of assessment 4.1 written exam 100 Total 100 5- List of references: 5.1- Course Notes (paper and / or electronic) Lectures (handouts – electronic) 5.2- Essential Books (Text Books) Davidson’s principle and practice of Medicine Primer of rheumatic diseases 5.3- Recommended Books ………………………………………… ………………………………………… 5.4- Periodicals, Web Sites, etc 20 http://books.google.com/books?id=dMIFiNR0I7YC&pg=PA5&lpg=PP1&ots=ptiu Yq7bNq&dq=genetics+in+rheumatology C. Immunology University: Ain Shams University Faculty: of Medicine Course specifications Program on which the course is given: Doctorate of Science in Histology. Major or minor element of programs: Minor. Department offering the program: Histology department. Department offering the course: Microbiology and Immunology department. Academic Level: Doctorate – at any semester Date of specification approval: ………………………….. A- Basic Information Title: microbiology course Code: E7011 Credit Hours: 2 hours Lecture: 2hs/week Coordinator Microbiology and Immunology department. Total: 30hs B - Professional Information 1- Course Aims: 1-To provide candidates with an understanding of the immune system, its protective functions and its role in the patho-physiology of infectious and noninfectious diseases 2- To enable the candidates to practice the principles of sterilization and infection control. 2- Intended Learning Outcomes (ILOs) from the Course: a- Knowledge and understanding By the end of the course the candidate will be able to: a1- Explain the physiology of the immune system, its beneficial role, as well as its detrimental role in hypersensitivity, autoimmunity and transplant rejection. a2- Describe recombinant DNA biotechniques. b- Intellectual skills By the end of the course the candidate will be able to: b1- Interpret immunological and molecular reports b2- Report and appraise a concise scientific activity according to standard scientific thinking and integrity 21 c- Professional skills By the end of the course the candidate will be able to: c1- Identify culture media and biochemical tests commonly used for bacterial identification and distinguish positive and negative results c2- Perform hand wash and control of steam sterilization c3- Select the proper investigation. d- General and transferable skills By the end of the course the candidate will be able to: d1- Work effectively in a group during preparation of seminars. d2- Respects the role of staff and co-staff members regardless of degree or occupation. 3- Course content: Topics Basic immunology: Tissues and cells of immune response, types of immune response, Immunoglobulins, Humoral immune response, complement, Ag-Ab reactions Cell-mediated immunity, Cytokines, immunity to bacterial infection and immunoprophylaxis Hypersensitivity Autoimmunity and tumor Immunology Immupodeficiency and infections in immunocompromized host L: Lecture 4 - Student Assessment Methods 4.1written exam to assess knowledge and understanding Weighing of assessment 4.1 written exam 100 5 -- List of References 5.1- Course Notes (paper and / or electronic) 5.2- Essential Books (Text Books) Jawetz, Melnick and Adelberg’s Medical Microbiology 5.3- Recommended Books 22 No. of hours L 15 5 5 5 5.4- Periodicals, Web Sites, etc http://www.phage.org/black09.htm http://www.microbe.org/microbes/virus_or_bacterium.asp http://www.bact.wisc.edu/Bact330/330Lecturetopics http://whyfiles.org/012mad_cow/7.html http://www.microbelibrary.org/ http://www.hepnet.com/hepb.htm http://www.tulane.edu/~dmsander/Big_Virology/BVHomePage.html http://www.mic.ki.se/Diseases/c2.html http://www.med.sc.edu:85/book/welcome.htm http://www.biology.arizona.edu/immunology/microbiology_immunology.html D. Molecular biology course specification University: Ain Shams University Faculty: of Medicine Course specifications Program on which the course is given: Doctorate of Science in Histology. Major or minor element of programs: Minor Department offering the program: Histology department. Department offering the course: Medical biochemistry and Molecular biology department Academic Level: Doctorate at any semester. Date of specification approval: ………………………….. A- Basic Information Title: Molecular biology course Credit Hours: 2 hours Code: E7012 Lecture: 2hs/week Total: 30hs Coordinator Medical biochemistry and Molecular biology department B - Professional Information 1- Course Aims: By the end of the course the candidate will be able to: a) Gain a thorough understanding of the basic principles of molecular biology. b) Understand the tools of DNA technology. c) Read and interpret scientific papers. d) Design approaches to addressing questions in molecular biology e) Understand the applications of molecular biology in rheumatology. 2- Intended Learning Outcomes (ILOs) from the Course: 23 a- Knowledge and understanding By the end of the course the candidate will be able to: a1 - Describe the chemistry of nucleotides and nucleic acids. a2 - Point out the processes of replication, transcription and translation. a3 - Describe recombinant DNA biotechniques. a4 - Describe the structure of heme and uric acid metabolism. a5 - Describe the structure of collagen and collagen metabolism. b- Intellectual skills By the end of the course the candidate will be able to: b1 - Select the proper investigation for rheumatic diseases. b2 - Read and evaluate scientific literature in the molecular biology sciences. c- Professional skills By the end of the course the candidate will be able to: c1- Recognize basic principle of DNA extraction c2 - Be aware of further techniques using the extracted DNA. c3- Read and evaluate scientific literature in the molecular biology sciences. d- General and transferable skills By the end of the course the candidate will be able to: d1 - Work effectively in a group during preparation of seminars. d2- Respects the role of staff and co-staff members regardless of degree or occupation. 3- Course content: No. of hours L T C/P Topics Basic Techniques DNA structure DNA replication DNA repair Transcription and post transcription Protein synthesis (Translation ) Post translation processing PCR (Applications of polymerase chain reaction in rheumatology) 24 2 2 2 2 2 2 4 SDL Special topics Blotting (western, southern and 2 northen) Recombinant technique 2 Apoptosis 3 Angiogenesis 2 Tolerance 2 Collagen metabolism 3 2 L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning 4 - Student Assessment Methods 4.1written exam to assess knowledge and understanding Weighing of assessment 4.1 written exam 100 Total 100 5 -- List of References 5.1- Course Notes (paper and / or electronic) Electronic lectures 5.2- Essential Books (Text Books) Lecture notes on molecular medicine 5.3- Recommended Books ……………………………………… 5.4- Periodicals, Web Sites, etc http://www.web-books.com/MoBio/ http://www.coe.uncc.edu/~hhilger/EB_I_F_06/web_links_on_basics_of_molecular _biology.htm Basics http://plato.acadiau.ca/courses/biol/Microbiology/Basics.htm Cell structure http://www.wiley.com/legacy/college/boyer/0470003790/animations/cell_structure /cell_structure.htm http://www.cellsalive.com/cells/3dcell.htm DNA http://www.pbs.org/wgbh/nova/genome/dna.html# http://www.johnkyrk.com/DNAanatomy.html good link http://www.pwc.k12.nf.ca/wadey/biotech/dna1.swf 25 Replication http://www.johnkyrk.com/DNAreplication.html http://highered.mcgrawhill.com/sites/0072437316/student_view0/chapter14/animations.html# http://www.wiley.com/college/pratt/0471393878/student/animations/dna_replicatio n/index.html Transcription http://www.johnkyrk.com/DNAtranscription.html very good link Protein synthesis http://www.johnkyrk.com/DNAtranslation.html very good link http://www.wisc-online.com/objects/index_tj.asp?objid=AP1302 http://highered.mcgrawhill.com/sites/0072437316/student_view0/chapter15/animations.html http://learn.genetics.utah.edu/units/basics/transcribe/ http://library.thinkquest.org/20465/g_DNATranscription.html http://www.brookscole.com/chemistry_d/templates/student_resources/shared_reso urces/animations/protein_synthesis/protein_synthesis.html http://www.biostudio.com/demo_freeman_protein_synthesis.htm Beginner’s guide to molecular biology http://www.rothamsted.ac.uk/notebook/courses/guide/ http://publications.nigms.nih.gov/insidethecell/chapter1.html http://www.cs.washington.edu/homes/tompa/papers/molbio.pdf http://en.wikipedia.org/wiki/Central_dogma_of_molecular_biology http://en.wikipedia.org/wiki/Molecular_biology PCR http://www.escience.ws/b572/L3/L3.htm http://www.bio.com/protocolstools/protocol.jhtml?id=p1242 http://users.ugent.be/~avierstr/principles/pcr.html http://depts.washington.edu/genetics/courses/genet371b-aut99/PCR_contents.html [animation] http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/pcr.html [animation] Southern blot http://www.accessexcellence.org/RC/VL/GG/southBlotg.html 26 http://highered.mcgrawhill.com/olcweb/cgi/pluginpop.cgi?it=swf::535::535::/sites/dl/free/0072437316/120 078/bio_g.swf::Southern%20Blot Northern blot http://www.ambion.com/techlib/basics/northerns/index.html http://homepages.strath.ac.uk/~dfs99109/BB211/RecombDNAtechlect2.html#sout herns Western blot http://www.bme.gatech.edu/vcl/WesternBlotting/Background/Introduction.htm http://www.bio.davidson.edu/courses/genomics/method/Westernblot.html http://www.westernblotting.org/ Animated Techniques: http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/molecularbi ology.html V- General Information 1 – Monitoring Of Training and Submission Of Training Reports You must keep proper and updated records in your logbook to reflect the activities encountered in your training. Your logbook must be duly endorsed by an authorized signatory at the end of each semester. You will be continuously assessed by your supervisors, in consultation with head of department. An assessment will be submitted within 2 weeks of completion of each semester. 2 - Miscellaneous Information: Injury and/or Blood or Body Fluid Exposure: During regular working hours, you should immediately report an exposure incident to any harmful chemical. If exposure occurs after regular working hours or during a weekend or holiday; please call the Toxicology Unit at Ain Shams Hospital. For injury, please report to the Emergency Department. Please also be sure to inform the supervisors of an exposure incident and/or injury. 3 - Action Completion Of Clinical Training 27 Once all training sessions are completed the log book should be signed by the senior supervisor and the head of the department and then should be submitted to post graduate Secretariat. 4- Reference The Training Guide is available at the post graduate Secretariat. --------------------------------------------------------------- VI – Your log book 1- Introduction The aim of this book is to give you a guide to the expectations for each item. It will be a guide for both you and your teachers to what you should be seeing and doing. It will give you a list of the important topics that you should think about and should be covered in: 1. Practical sessions. or 2. Tutorials or 3. Self-directed learning (SDL) For each item there is also a list of 1. Practical sessions to be seen or attended. 2. Practical procedures to be seen and done Remember This document is only a guide. It is not an exhaustive list. It is not just a checklist to score points. It is a guide to encourage you to read and learn more. This book is for your benefit. It will form a record of your clinical training and experience. 2 - Supervisors 28 ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………………………………… ……………………………………………………………… 3–Tables for Training Records Candidates are required to fulfill 75% of the listed activities in order to be eligible for the exam entry. The minimum number required for each activity = 75%. You are free to attend more and record your extra attendance. Weekly Department Plan Day /time Saturda y Sunda y 8-10 Monda y lectures Group 11.30discussio 1.30 n Slide 11.30training 1.30 Slide prepratio n Prelab. ك ايب teaching لادي Monthly activity: Seminars Sixth monthly activity: researches Yearly activity: conferences. Tuesda y Wednesda y 3-5 10-11.30 3-4.30 Conferences attendance (NB. Minimum number required is 6) 29 Thursda y Place Date No Annual conference of Histology Annual conference of Faculty of Medicine, Ain Shams University Supervisor signature Seminars attendance (NB. Minimum number required is 12) No Date Place Topics Supervisor signature Thesis attendance (NB. Minimum number required is10) No Date Place Name of the thesis 30 Supervisor signature Tutorials Attended (NB. Minimum number required is 12/course) No No Date Place Name of the tutorial Supervisor signature Teaching Prelabs (NB. Minimum number required is 10 (present 3 models of a lecture Supervisor Date Place Name signature Interactive learning (present an updated subject or technique) (NB. Minimum number required is 1/semester) 31 No Date Supervisor signature Primary diagnosis 10 Special staining techniques: 10 Silver 10 Stain for eleastic fs 10 Stain for collagen Histochemistry 2 Advanced techniques (two are recommended): 2 -ultrathin resin -Ulrathinmicrotome –immunohistochemistry -Immage analyzer aPoor b- Satisfactory c- Excellent 5 - Log book preview The candidate logbook will be reviewed and patients seen/ skills performed summarized by diagnosis groups during the semester evaluation and at the end of 32 Supervisor signature Date Done independently (A, B, C) According to each department Date assisted Date Observed No Item Practical skills (Agreement Scale) Requirements Candidates are required to fulfill 75% of the listed activities in order to be eligible for the exam entry. The minimum number required for each activity = 75%. You are free to attend more and record your extra attendance. the course in the table below. The results of this review will be totaled in the summary chart below. Summary Semester 1st 2nd 3rd 4th 5th 6th Total Activity No No No No No No Conference attendance Seminars attendance Thesis attendance Tutorials attendance Teaching pre-labs Interactive learning Practical skills Supervisor signature VII - Head Of Department Approval For The Exam Entry __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ ____________________________________________________ 33 34 VIII – Thesis Follow up التقرير النصف السنوى لعام / عن الطالب / المقيد لدرجة ( ماجسيتر ) بقسم / تقرير السادة االساتذة المشرفين جمع المادة العلمية و كتابة المقدمة الجزء العملى مناقشة النتائج المراجعة النهائية مع المشرف رأى السادة المشرفين التاريخ/ بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من الجمع بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحليل بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحرير بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهت تماما إستمرار قيد الطالب 35 مد القيد شطب قيد الطالب تم تشكيل لجنة المناقشة تاريخ التشكيل نعم ال مد /شطب القيد توقيع السادة المشرفين وكيل الكلية 36 / / التقرير النصف السنوى لعام / عن الطالب / المقيد لدرجة ( ماجسيتر ) بقسم / تقرير السادة االساتذة المشرفين جمع المادة العلمية و كتابة المقدمة الجزء العملى مناقشة النتائج المراجعة النهائية مع المشرف رأى السادة المشرفين التاريخ/ بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من الجمع بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحليل بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحرير بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهت تماما إستمرار قيد الطالب 37 مد القيد شطب قيد الطالب تم تشكيل لجنة المناقشة تاريخ التشكيل نعم ال مد /شطب القيد توقيع السادة المشرفين وكيل الكلية 38 / / التقرير النصف السنوى لعام / عن الطالب / المقيد لدرجة ( ماجسيتر ) بقسم / تقرير السادة االساتذة المشرفين جمع المادة العلمية و كتابة المقدمة الجزء العملى مناقشة النتائج المراجعة النهائية مع المشرف رأى السادة المشرفين التاريخ/ بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من الجمع بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحليل بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحرير بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهت تماما إستمرار قيد الطالب 39 مد القيد شطب قيد الطالب تم تشكيل لجنة المناقشة تاريخ التشكيل نعم ال مد /شطب القيد توقيع السادة المشرفين وكيل الكلية 40 / / التقرير النصف السنوى لعام / عن الطالب / المقيد لدرجة ( ماجسيتر ) بقسم / تقرير السادة االساتذة المشرفين جمع المادة العلمية و كتابة المقدمة الجزء العملى مناقشة النتائج المراجعة النهائية مع المشرف التاريخ/ بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من الجمع بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحليل بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحرير بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهت تماما 41 رأى السادة المشرفين إستمرار قيد الطالب مد القيد شطب قيد الطالب تم تشكيل لجنة المناقشة تاريخ التشكيل نعم ال مد /شطب القيد توقيع السادة المشرفين وكيل الكلية 42 / / التقرير النصف السنوى لعام / عن الطالب / المقيد لدرجة ( ماجسيتر ) بقسم / تقرير السادة االساتذة المشرفين جمع المادة العلمية و كتابة المقدمة الجزء العملى مناقشة النتائج المراجعة النهائية مع المشرف رأى السادة المشرفين التاريخ/ بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من الجمع بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحليل بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحرير بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهت تماما إستمرار قيد الطالب 43 مد القيد شطب قيد الطالب تم تشكيل لجنة المناقشة تاريخ التشكيل نعم ال مد /شطب القيد توقيع السادة المشرفين وكيل الكلية 44 / / التقرير النصف السنوى لعام / عن الطالب / المقيد لدرجة ( ماجسيتر ) بقسم / تقرير السادة االساتذة المشرفين جمع المادة العلمية و كتابة المقدمة الجزء العملى مناقشة النتائج المراجعة النهائية مع المشرف التاريخ/ بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من الجمع بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحليل بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحرير بدأ قطع شوطا محدودا 45 أوشك على اإلنتهاء رأى السادة المشرفين إستمرار قيد الطالب إنتهت تماما مد القيد شطب قيد الطالب تم تشكيل لجنة المناقشة تاريخ التشكيل نعم ال مد /شطب القيد توقيع السادة المشرفين وكيل الكلية 46 / / VIII – Evaluation Forms To be completed at ------------------------------------Candidate Supervisor Location Aim of training __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Candidate __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ 47 __________________________________________________________________ __________________________________________________________________ Comments by Supervisor __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Date of next meeting Signed by candidate Signed by Supervisor Date 48 VIII – Evaluation Forms To be completed at ------------------------------------Candidate Supervisor Location Aim of training __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Candidate __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ 49 __________________________________________________________________ __________________________________________________________________ Comments by Supervisor __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Date of next meeting Signed by candidate Signed by Supervisor Date 50 VIII – Evaluation Forms To be completed at ------------------------------------Candidate Supervisor Location Aim of training __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Candidate __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ 51 __________________________________________________________________ __________________________________________________________________ Comments by Supervisor __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Date of next meeting Signed by candidate Signed by Supervisor Date 52 VIII – Evaluation Forms To be completed at ------------------------------------Candidate Supervisor Location Aim of training __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Candidate __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ 53 __________________________________________________________________ __________________________________________________________________ Comments by Supervisor __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Date of next meeting Signed by candidate Signed by Supervisor Date 54 VIII – Evaluation Forms To be completed at ------------------------------------Candidate Supervisor Location Aim of training __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Candidate __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ 55 __________________________________________________________________ __________________________________________________________________ Comments by Supervisor __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Date of next meeting Signed by candidate Signed by Supervisor Date 56 VIII – Evaluation Forms To be completed at ------------------------------------Candidate Supervisor Location Aim of training __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Candidate __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ 57 __________________________________________________________________ __________________________________________________________________ Comments by Supervisor __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Date of next meeting Signed by candidate Signed by Supervisor Date 58 Degree Program Evaluation Form by The Candidate To be completed at the end of your degree. Please consider each pair of statements and decide which most clearly reflects your view and tick one box or answer the question. I. Individual Information 1. Are you a graduate of ASU? yes no to some degree 2. Year and semester when studies began: II. General Questions 1. What are the advantages/disadvantages of the general study environment at the University ASU? 2. What were your expectations when you applied to the degree? 3. Do you feel that the degree program prepares you well for your future studies or employment according to the demands and expectations of those institutions? yes no to some degree 59 4. Has the time limit of the program (two or three academic years) caused you any difficulties or inconveniences? yes no to some degree III. Structure of Degree Program 1. Did you receive enough guidance in planning your study schedule in the beginning of the program? yes no to some degree 2. What were the main difficulties in the planning of your study schedule? 3. What is your general opinion on the structure of the degree program? 4. In your opinion, does the degree program offer a good balance of lectures, seminars, conferences, and book exams? yes no to some degree a) General Studies i) Do you feel that you have received enough guidance on academic writing? yes no to some degree ii) Do you feel that you have acquired sufficient knowledge on research skills (eg. quantitative and qualitative research methods)? yes no to some degree b) Courses i) Have you had some special difficulties in completing some of the courses? Please specify. ii) Has there been a sufficient variety of courses offered for your optional studies? yes no to some degree iii) Have you received enough guidance for the preparation of your thesis? 60 yes no to some degree IV. Concluding Points 1. Did the degree 2. yes What no aspects program to some degree of the degree meet program do your you expectations? particularly like? 3. What aspects of the degree program do you particularly dislike? 4. What are your suggestions on Thank you! 61 how to improve the program?