Chapter 12 An Overview of the Nervous System- Complex organ system that contains neurons, neuroglia. Divided into two divisions, CNS and PNS ▪CNS ▪PNS ▫Afferent Division ▫Efferent Division -Somatic Nervous System (SNS) -Autonomic Nervous System (ANS) Neurons ▪The Structure of Neurons- Use figures 12-2 and 12-3 to locate the following cell structures ▫Cell Body (soma) ▫Perikaryon ▫Neurofiliments and neurotubules and neurofibrils ▫Nissl bodies ▫Dendrites ▫Axon -axoplasm and axolemma -axon hillock -initial segment -collaterals -telodendria 1 ▫Axon terminals ▫Synapse -neurotranmitters -neuromuscular and neuroglandular junctions -presynaptic and postsynaptic membranes -axoplasmic transport ▪Classification of Neurons ▫Structural Classification -Anaxonic -Bipolar -Unipolar -Multipolar ▫Functional Classification of Neurons -Sensory (Afferent)- deliver information from the sensory receptors to the CNS. -Cell bodies are located in peripheral sensory ganglia -Somatic sensory neurons- monitor outside world -Visceral sensory neurons- monitor internal conditions - Interoceptors -Exteroceptors -Proprioceptors 2 -Motor (Efferent)- carry instructions from the CNS to peripheral effectors. -Somatic motor neurons -Visceral motor neurons -Interneurons (association) Neuroglia- supporting cells of the nervous system ▪Neuroglia of the Central Nervous System- CNS has 4 types of neuroglia ▫Ependymal cells ▫Astrocytes 1) 2) 3) 4) 5) ▫Oligodentrocytes ▫Microglia ▪Neuroglia of the Peripheral Nervous System ▫Cell bodies of neurons in the PNS are clustered in masses called ganglion ▫Satellite Cells ▫Schwann Cells *use figure 12-7 to help distinguish between myelinated and nonmyelinated axons* 3 Neural Responses to Injuries ▪Neurons can respond to injury in a very limited, stereotyped way ▪Limited regeneration can occur in the CNS, but the situation is complicated. Neurophysiology: Ions and Electrical Signals ▪There are five important membrane processes that will be discussed: 1) All living cells have a transmembrane potential that varies depending on the activities of the cell. 2) A typical stimulus can produce a local graded potential, which decreases with distance from the stimulus. 3) A large graded potential can produce an action potential in the axon membrane. This does not diminish with distance from the stimulus. 4) Synaptic activity produces a graded potential on the postsynaptic cell that is usually caused by neurotransmitters. 5) Response of postsynaptic cell can vary depending on the response of the receptor that was stimulated *see fig. 12-7 for an overview of these important processes* ▪Transmembrane Potential- three important concepts regarding the transmembrane potential: 1) 2) 3) ▫Passive forces include: -Chemical gradients -Electrical gradients -Electrochemical gradient ▫Active forces include the sodium/potassium exchange pump 4 ▪Changes in the transmembrane potential ▫Resting potential is the transmembrane potential of an “undisturbed” cell ▫Membrane channels control the movement of ions across the cell membrane, we will focus on sodium and potassium channels. -They can either be passive (leak) or active (gated), there are three types of active (gated) channels 1) 2) 3) ▪Graded Potentials- also called local potentials ▫Changes in the transmembrane potential that cannot spread far from the area surrounding the site of stimulation. ▫Can be depolarizing or hyperpolarizing, depending on stimulus *Use figure 12-12 to visualize the process of a graded potential* ▪Action Potentials- propagated changes in the transmembrane potential that affect an entire excitable membrane. ▫All-or-none principle ▫Generation of Action potentials- *use figure 12-14 to visualize the process of an action potential* ▫The refractory period- the time from the initiation of an action potential until the normal resting potential has returned. -Absolute refractory period -Relative refractory period ▫The role of the sodium-potassium exchange pump is to return cell to pre-stimulation conditions of these ions. (Na out, K in) 5 ▫Propagation of Action Potentials- action potentials moving down axon. -Continuous propagation-Saltatory propagation▫Axon diameter affects propagation speed. -Type A fibers -Type B fibers -Type C fibers Synaptic Activity ▪Electric events of messages moving from one place to another are called nerve impulses. ▪General Properties of Synapses ▫Electrical synapse -Extremely rare -Presynaptic and postsynaptic cell are locked together at gap junctions -Action potentials are propagated quickly ▫Chemical synapse -Most neural synapses, all between neurons and other cells -Neurotransmitters released into synapse, picked up by receptors on postsynaptic cell -Can be excitatory or inhibitory neurotransmitters ▪Cholinergic synapses- release of ACh at synapse. ▫Each vesicle in synaptic knob contains thousands of molecules of ACh, can be a million vesicles in one synaptic knob ▫Events at a cholinergic synapse; assume synapse is adjacent to initial segment of axon. 6 ▫ACh is broken down into acetate and choline, reabsorbed and used again by local cells. *see figure 12-16 to see the events at a cholinergic synapse* ▫Synaptic Delay▫Synaptic Fatigue- Information Processing ▪Postsynaptic potentials- graded potentials that develop in the postsynaptic membrane in response to a neurotransmitter, two types. ▫Excitatory postsynaptic potential (EPSP)- ▫Inhibitory postsynaptic potential (IPSP)- ▫Summation- process of combining postsynaptic potentials that affect one portion of the cell membrane. Can be EPSP’s, IPSP’s, or both. Two types: -Temporal summation-Spatial summation▫Facilitation▪Presynaptic Inhibition and Facilitation *use figure 12-20 to visualize examples of presynaptic inhibition and facilitation.* 7