CURRICULUM VITAE
Prof.Y. NARSIMHA REDDY
M.Pharm, PhD
University College of pharmaceutical sciences,
Kakatiya University
Warangal 506009, A.P., INDIA
Email: ynrku@yahoo.co.in
nyellu@gmail.com
Contact: Work: 0870-2438844 (O); Personal: 09440705384
Education:
 PhD majoring Pharmaceutical Sciences, Kakatiya University, Warangal, India,
Nov.2004.
 M.Pharm majoring in Pharmacology, Kakatiya University, Warangal,, India.
Jannuary 1996.
 B.Pharm majoring in Pharmaceutical Sciences, Kakatiya University, Warangal,
Oct 1990
 Professional Diploma in Clinical Research (PDCR) Catalyst Clinical Services,
New Delhi
Professional (Teaching & Research) experience: 18years
Teaching Pharmacology, Clinical Pharmacy & Therapeutics and Biopharmaceutics,
at UG & PG levels.
RESEARCH INTERESTS:
1. Clinical Pharmacokinetics
2. Population Pharmacokinetics
3. Pharmacovigilance
4. Cancer Biology
5. Evaluation of Biological and Toxicological Effects of Nanomaterials using in vitro &
in vivo Models
6. Pharmacological screening of herbal drugs with specific interest in
Cardiovascular Pharmacology and Diabetes
Professional Fellowships & memberships :
(FIC)
Associate fellow of A.P Academy of science
(IPA).
(APTI).
Other positions:
- Board of Studies of some Indian Universities
Examiner for some Indian universities
Completed and on going research Projects:
Completed:1. DST (Rs. 13,48,000/-): Cytotoxicity of carboan nanomaterals
2.UGC- MRP (Rs.12 Lakhs) – Population Pharmacokinetics of some Cardiovascular
Drugs.
3.AICTE- RPS (Rs. 13 Lakhs) – Cytotoxicity of some Engineered nanomaterials
4.AICTE –MODROBS (Rs 18 Lakhs) – Population Pharmacokinetics and clinical
response of some anti-hypertensive drugs
On going: AICTE – RPS (Rs 22.5 Lakhs)- .Neuroimmune and neuroprotective activities of some
Indian Medicinal plants.
Number of research projects guided:
PG level:
Completed: 24 students
Guiding presently: 05 students
Ph. D level:
Completed: 15 students
Guiding presently: 08 students
Research Publications: 70 (National & International)
Research Presentations: 25 (National & International)
Research Publications:
1. Venkateshwarlu Kodhati, Malla Reddy Vanga and Narsimha Reddy Yellu
(2014).Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New Smannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones.Journal of
the Korean Chemical Society 2013;57(2):234-240.
2. E. Rajanarendar , K. Govardhan Reddy , S. Rama Krishna ,B. Shireesha , Y.
N. Reddy , M. V. Rajam (2013). Design, synthesis, antimicrobial, antiinflammatory, and analgesic activity of novel dihydrobenzo furo[3,2e]isoxazolo[4,5-b]azepin-5(5aH)-ones. Med Chem Res,44(13):598-601.
3. Mohammad Zubair Shareef, Narsimha Reddy Y , Venkata Narsimha Appa
Rao A (2013). Neuropharmacological screening of essential oil from oleo
gum
resin
of
Gardenia
lucida
Roxb.
Journal
of
Ethnopharmacology,149(3):621-625.
4. E. Rajanarendar , S. Ramakrishna , K. Govardhan Reddy , D. Nagaraju ,Y.
N. Reddy. A facile synthesis, anti-inflammatory and analgesicactivity of
isoxazolyl-2,3-dihydrospiro[benzo[f]isoindole-1,30indoline]-20,4,9triones. Bioorganic & Medicinal Chemistry Letters 23 (2013) 3954–3958.
5. Venkateshwarlu Kodhati, Malla Reddy Vanga, Narsimha Reddy Yellu
(2013). Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New Smannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones. Journal
of the Korean Chemical Society, 57(2):234-240.
6. E.Rajanarendar,K.GovardhanReddy,S.RamaKrishna,M.NagiReddy,B.Shireesha,G.Dur
gaiah,Y.N. Reddy (2012). Synthesis and in vitro and in vivo anticancer
activity of novel 3-methyl,4,6] Pyrido [2,3-b] indoles. Bioorganic &
Medicinal Chemistry Letters. 22(21): 6677-6680.
7. Venkateshwarlu Kodhati, Malla Reddy Vanga, Narsimha Reddy Yellu
(2013). Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New Smannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones. Journal
of the Korean Chemical Society, 57(2):234-240.
8. E.Rajanarendar, M.NagiReddy ,S.RamaKrishna, K.Rama Murthy ,Y.N.
Reddy,M.V.Rajam
(2012).Design,Synthesis,antimicrobial,anti-inflammatory
and analgesic activity of novel isoxazolyl Pyrimido[4,5-b]quinolines and
isoxazolylchromeno[2,3-d]pyrimidin-4-ones.
European
Journal
of
Medicinal Chemistry, 55:273-2283.
9. E. Rajanarendar, S.Raju, M. Nagi Reddy,S.Rama Krishna,L.hari Kiran,A.Rama
Narsimha Reddy, Y.Narsimha Reddy (2012). Multi-component synthesis and
in vitro and in vivo anticancer activity of novel arylmethylene bisisoxazolo[4,5-b]pyridine-N-oxides.
European
Journal
of
Medicinal
Chemistry, 50:274-279.
10. E. Rajanarendar , M. Nagi Reddy , S. Rama Krishna, K. Govardhan Reddy , Y.N.
Reddy , M.V. Rajam (2012). Design, synthesis, in vitro antimicrobial and
anticancer
activity
of
novel
methylenebis-isoxazolo[4,5-b]azepines
derivatives. European Journal of Medicinal Chemistry, 50:344-349.
11. E. Rajanarendar, M. Nagi Reddy , K. Rama Murthy , P. Surendar , R.N.
Reddy , Y.N. Reddy(2012). Synthesis and in vitro and in vivo anticancer
activity
of
novel
phenylmethylene
bis-isoxazolo[4,5-b]azepines.
Bioorganic & Medicinal Chemistry Letters. 22: 149–153.
12. P.Shankaraiah, D.Raju Y.NarsimhaReddy (2012).Alpha amylase inhibitory
activity of flavonoids in diabetic induced rats. Journal of Pharmacy Research,
5(2):1183-1187.
13. J.C. Hanish Singh, V. Alagarsamy, Prakash V. Diwan, S. Sathesh
Kumar,J.C. Nisha, Y. Narsimha Reddy(2011).Neuroprotective effect of
Alpinia galanga (L.) fractions on A_(25–35) induced amnesia in mice.
Journal of Ethnopharmacology, 138: 85– 91.
14. J. C. Hanish Singh, V. Alagarsamy,S. Sathesh Kumar and Y. Narsimha
Reddy (2011). Neurotransmitter Metabolic Enzymes and Antioxidant Status
onAlzheimer’sDisease Induced Mice Treated with Alpinia galanga (L.)
Willd. Phytother. Res. 25: 1061–1067.
15. J. C. Hanish Singh, V.Alagarsamy, P.Prtibhan, P.Selva Kumar and Y.
Narsimha Reddy (2011).Neuroprotective potential of ethanolic extract of
Pseudathria viscida(L) Wight and Arn againest B-amyloid induced amnesia
in mice. Ind J Biochem. Biohys., 48:197-201.
16. CH Ravikanth, A Anil Kumar, V Uday Kiran, S.Prashanth, B.Madhu, Y.
Narsimha Reddy (2011).Sensitive and rapid HPLC method for the
determination of pioglitazone in rat serum. Int. J Pharm. Sci. Drug Res.,
3(1): 38-41.
17. H. Parameshwar, B. Babu Rao, B. Ravi Kumar, Y. Narsimha Reddy and G.
Krishna Mohan (2011). Hepatoprotective effect of methanolic extract of the
leaves of Kydia calycina on carbon tetrachloride induced hepatotoxicity in
albino rats. African Journal of Pharmacy and Pharmacology,5(16): 19201924.
18. H. Parameshwar, B. Ravi kumar, G. Krishna Mohan, V. Raju and Y.
Narsimha Reddy (2011). Hepatoprotective effect of the methanolic extract
of whole plant of Borreria articularis on carbon tetrachloride induced
hepatotoxicity in albino rats. JPRHC, 2(4):285-292.
19. P.Shankaraiah,Y.N.Reddy (2011). Alpha Amylase expressions in Indian
Type-2 diabetic patients. J.Med.Sci. 11(7):280-284.
20. H. Parameshwar, B. Ravi kumar, G. Krishna Mohan, V. Raju and Y.
Narsimha Reddy (2010).Protective effect of methanoloic fruit extract of
Solina amplexicaulis in carbon tetrachloride induced hepatotoxicity on
rats.S.j.Pharm.Sci.,3(2):1-6.
21. A.Rama Narsimha Reddy, Y.Narsimha Reddy, D.R.Krishna and
V.Himabindu(2010). Multi wall carbon nanotubes induce oxidative stress
and cytotoxicity in human embryonic kidney (HEK293) cells. Toxicology.
272: 11-16.
22. A.Rama Narsimha Reddy, M. Venkateswar Rao, Devarakonda R. Krishna,
V. Himabindu and Y. Narsimha Reddy (2010).Evaluation of oxidative
stress and anti-oxidant status in rat serum following exposure of carbon
nanotubes .Regulatory Pharmacology & Toxicology59(2):251-257.
23. U.K.Veldandi,
N.R.Yellu,
N.Malothu,
R.K.Devarakonda
(2010).
Development and Validation of HPLC Method for the determination of
Losartan in Human plasma. Reviews in Analytical Chemistry, 29(1):59-67.
24. V.Uday
Kiran,N.Venkat
Rajaiah,D.R.Krishna,
Y.Narsimha
Reddy
(2010).Effect of Losartan and Ramipril on oxidative stress and antioxidant
status in south Indian hypertensive patients.Int.J Pharmacology,6(6):916920.
25. A.Rama Narsimha Reddy, Y.Narsimha Reddy, R. K. Devarakonda and
V.Himabindu (2010). In Vitro Toxicity of Multi Wall Carbon Nanoparticles
on
Hep
G32
Liver
Cell
Lines.
Journal
of
Pharmacology
&
Toxicology,5(4):146-151.
26. A.Rama Narsimha Reddy, Y.Narsimha Reddy, D.R.Krishna and
V.Himabindu(2010). In vitro cytotoxicity of multi wall carbon nanotubes on
human cell lines. Toxicological and Environmental Chemistry,92(9):16971703.
27. A.Rama Narsimha Reddy, Y. Narsimha Reddy, D. R. Krishna and V
.Himabindu (2010). Pulmonary Toxicity Assessment of Multi-wall Carbon
Nanotubes in Rats following Intratracheal Instillation. Environmental
Toxicology, 27(1):3-10.
28. A.Rama Narsimha Reddy, Y. Narsimha Reddy, D.R.Krishna and
V.Himabindu (2010). Translocation and extra pulmonary toxicity of Multiwall Carbon Nanotubes in Rats. Toxicology Mechanisms and Methods,
20(5):267-272.
29. P. Shankaraiah, Y.Narsimha Reddy, A.Venkatesham, N.Venkata Rajaiah
D.R.Krishna (2010).Differential Expression of Glucokinase activity in Type
-2 Indian diabetes patients. Int. J. Pharmacology, 6(4):496-500.
30. R.N.R.Anreddy, M.Porika, N.R.Yellu and R.K.Devarakonda (2010).
Hypoglycemic and Hypolipidemic activities of Trianthema portulacastrum
Linn. Plant in normal and alloxan induced diabetic rats .Int. J.
Pharmacology, 6(2):29-133.
31. Shankaraiah Puligilla, Venkatesham Allenki , Rama Krishna Devarakonda,
Narsimha Reddy Yellu (2010). Influence of HbA1C on Dipeptidyl
Peptidase-IV activity in Indian type-2 diabetic patients. Journal of
Pharmacy Research, 3(9):2300-2302
32. Nagulu Malothu, Uday Kiran Veldandi, Narsimha Reddy Yellu, Nalini
Yadala, Rama Krishna Devarakonda(2010). Population Pharmacokinetics of
5-Flouro Uracil In Indian Cancer Patient Population. Asian J.Pharm. & Clin.
Res., 3(3):197-200.
33. M.Nagulu, V. Uday Kiran, Y.Nalini, Y Narsimha Reddy, D Rama Krishna
(2010). Population Pharmacokinetics of Methotrexate in Indian Cancer
Patients. Asian Pacific Journal of Cancer Prevention, 11: 403-410.
34. Bhukya Baburao, Anreddy Rama Narsimha Reddy, Gangarapu Kiran, Yellu
Narsimha Reddy, Gottumukkala Krishna Mohan (2010). Antioxidant,
analgesic and anti-inflammatory activities of Leucas cephalotes (Roxb.ex
Roth) Spreng. Brazilian Journal of Pharmaceutical Sciences, 46(3):526529.
35. T.Radhika, P.Mahender, A.Venkatesham, A.R.N.Reddy, Y.Narsimha
Reddy, A.Sadanandam,T.Christopher (2010). Hypoglycemic activity of red
kino
tree
in
normal
and
streptozotocin
Int.J.Pharmacplogy, 6(3):301-305.
induced
diabetic
rats.
36. A.Venkatesham, N. Prasad, D.R. Krishna and Y.Narsimha Reddy (2009).
Dipeptidyl Peptidase-IV Inhibitory Activity of Parotid Exudate of Bufo
Melanostictus. Phcog Res., 1(2):98-101
37. M.Nagulu, V.Uday Kiran, K.Nalini, R.Dharak, Y.Narsimha Reddy,
D.Rama Krishna (2009). Oxidative stress and anti-oxidant status in breast
cancer patients. J. Pharm. Res., 2(1):62-65.
38. S
.Martha,
U.K.Veldandi,
R.Devarakonda
Krishna,
N
.Pantam,
S.Thungathurthi, N. Reddy Yellu (2009).Protective Effect of Aspirin in
Relation to IGF-I in Streptozotocin Induced Type-II Diabetic Rats. Int J
Endocrinol Metab., (1): 20-25.
39. K. Harish Kaushik, S. Vijay Kumar, B.Satish Kumar, Y.Narsimha Reddy,
V .K Raghavaiah and R.Krishna Devarakonda (2009). Population
Pharmacokinetics of Cisplatin in Asian Indian Cancer Patients. Clin. Res.
Regul. affairs, 26(4):84-92.
40. S. Vijay Kumar, K.Harish Kaushik, B. Satish Kumar, Y. Narsimha Reddy,
V .K. Raghavaiah and R. Krishna Devarakonda (2009). Population
Pharmacokinetics of Doxorubicin in Indian Cancer Patients .Clin. Res.
Regul. affairs, 26(4):93-100.
41. M.Srinivas , A.Rama Narsimha Reddy, D.R.Krishna ,P.Narayana ,
Y.Narsimha Reddy & Surender T(2009).Role of Liver in Progression of
Insulin Resistance in Relation to IGF-I and Insulin Levels in Rats with
Acute Hepatotoxicity . Lat. Am. J. Pharm. 28 (6):914-8.
42. A.Venkatesham , D.R.Krishna, A. Rama Narsimha Reddy, P.Narayana,
Y.Narsimha Reddy (2009). Fasting and Post Prandial Monitoring of
Dipeptidyl Peptidase-IV (DPP-IV)- A biomarker to assess Incretin response
in type-2 diabetes. Stamford J Pharm Sci. 2(2): 81-85.
43. Y.Narsimha Reddy, S.Vasudeva Murthy, D.R.Krishna and M.C.Prabhakar
(2009). Oxidative metabolic changes in pleural fluid of
tuberculosis
patients. Bangladesh J Pharmacol, 4: 69-72.
44. K.Prasanna Kumar, A. Janaki, A. Rama Narsimha Reddy and Y.Narsimha
Reddy (2009). Pharmacokinetics and Pharmacodynamics of Atorvastatin
alone and in Combination with Lercanidipine in Hyperlipidemic Rats. J.
Pharm. Res., 2(1):65-69.
45. P.
Shankaraiah,
A.Venkatesham,
N.Prasad,
Y.Narsimha
Reddy,
D.R.Krishna (2009).Does aspirin pretreatment prevents the diabetes in rats?
Pharmacology-online, 3: 596-605.
46. G.Kranthi, A.Rama Narsimha Reddy, Pavan Umate, Y.Narsimha
Reddy(2009). Sadanandam Abbagani (2009). Antioxidant and anti-diabetic
activities from leaf extracts of Streblus asper Lour. BTAIJ, 3(4): 232-235.
47. V.Venkata Rajesham ,A.Rama Narsimha Reddy , G.Rajyalakshmi , J.Anbu,
Y.
Narsimha
Reddy(2008).
Pharmacokinetics
of
Nifedipine
in
Hyperlipidemic Rats. Online J Pharmacokinetics, 4:18-23.
48. A.Venkatesham, D.R .Krishna and Y.Narsimha Reddy (2008).Dipeptidyl
Peptidase – IV (DPP-IV) inhibitory activity of metformin. Pharmacology
online, 2: 372-378.
49. M.Srinivas,
A.
Annapurna
,
Y.Narsimha
Reddy
(2008).
Anti-
atherosclerotic effects of atorvastatin and clopidogrel alone and in
combination in rats. Indian J Exptl Biol, 46: 698-700.
50. K. Prasanna Kumar, A. Rama Narsimha Reddy, J. Anbu and Y. Narsimha
Reddy (2008). Simultaneous determination of atorvastatin and lercanidipine
in rat plasma by HPLC and pharmacokinetic studies.AJPP, 8(4):299-304.
51. T.Radhika, P. Mahendar, A.V.Rao, A.Sadanandam, Y.Narasimha Reddy
and T.Christopher (2008). Analgesic Activity of Root Extract of Acorus
Calamus Linn. Pharmacologyonline, 3: 240-243.
52. K.Prasanna Kumar, A.Janaki, A.Rama Narsimha Reddy and Y.Narsimha
Reddy
(2008).Effect of hyperlipidemia on Pharmacokinetics of
Lercanidipine in experimental Rats. Pharmacology online 3: 581-585.
53. A.Rama Narsimha Reddy, D. R. Krishna and Y. Narsimha Reddy (2008).
A review on concepts of nanotechnology. Pharmacology online. 3: 175-186.
54. Y.Narsimha Reddy , V.Anil Kumar, M.Srinivas , V.Narayana Reddy
(2008).Study on Oxidative Metabolic Changes to Differentiate Exudative
from
Transudative Pleural Effusions. S. J. Pharm. Sci., 1(1&2): 39-44.
55. M.Nagulu, N.Prasad, M.C. Prabhakar, Y.N.Reddy (2008).Frog rectum as a
new experimental model in Pharmacology.IJCAP, 25(2):12-15.
56. B.Chandrasekhar Reddy, A.V.Jithan , Y.Narsimha Reddy and V.Malla
Reddy (2008).Fabrication and investigations on
hepatoprotective
activity of sustained release biodegradable piperine
microspheres.
IJPSN, 1(1):87-96.
57. B.R.Chandrasekhar , R.Srinivas . Challa, Y.Narsimha Reddy, A.Murali ,
A.V.Jithan
(2007).
Preparation
and
characterization
of
piperine
multilamellar vesicular liposomes Intended for Testing Anticonvulsant
Activity in Rats. Indian Drugs, 44(6):458-465.
58. K .Venkateswarlu, R.K .Venisetty, N. R. Yellu, S .Keshetty, M.G. Pai
(2007).
Development of HPTLC - UV absorption densitometry method
for the
analysis of alprazolam and sertraline in combination and its
application in the evaluation of marketed preparations. J. Chromatographic
Science, 45:1-3.
59. P.Govardhan, P.Laxmi
Y.Narsimha
,B. Diwakar , K.Thirupathi
Reddy,
G.KrishnMohan,P.RajeswaraRao(2007).Antinociceptive
inflammatory effects of Cleome chelidonni Linn. roots in
,M.B.Krishna,
B.Ravikumar,
and Antiexperimental
animals. Phcog Mag, 4(13):32-36.
60. K.Venkateswarlu, Y. N. Reddy, K.Srisailam,V. Rajkumar and M.G.Pai
(2007). Determination of tramadol in Capsules by high performance thin
layer chromatography – densitometry. CTBP, 2(3):421-425.
61. Y.N. Reddy, S.V. Murthy, D.R. Krishna, M.C. Prabhakar. (2004). Role of
free radicals and antioxidants in tuberculosis patients. Indian J. Tuberc.,
52:213-218.
62. Y.N. Reddy, S.V. Murthy, D.R. Krishna, M.C. Prabhakar. (2004).
Determination of antioxidant activity of some anti-tubercular drugs by using
HPLC. Indian J. Pharmaceutical Sciences, September-October, 702-703.
63. Y.N. Reddy, S.V. Murthy, D.R. Krishna, M.C. Prabhakar (2003). Oxidative
stress and antioxidant status in leprosy patients. Indian J. Lepr., 75(4): 1-10.
64. N.C. Srikanth, S.Gangadhar, Y. Narsimha Reddy, S.S.Apte, V.
Laxmipathi, A.V.N. Apparao, D.R. Krishna and M.C. Prabhakar (1997).
Characterization of Leprosy based on the nasal lipid profile. Indian J. Lepr.,
69(2): 179-181.
Papers presented in international conferences:
1. H.Kaushik, Y.N.Reddy, V. Sripuram, N. Malothu, R.K.Devarakonda. Population
Pharmacokinetics of Cisplatin (T3321).AAPS Annual meeting and Expositio,
USA, November 16-20, 2008.
2. V. Sripuram ,Y.N.Reddy, H.Kaushik, S.Bedada, R.K.Devarakonda.Development
and validation of rapid and sensitive HPLC method for the determination of
Doxorubucin in human plasma(M1004). AAPS Annual meeting and Expositio,
USA, November 16-20, 2008.
3. H.Kaushik, Y.N.Reddy, V. Sripuram, S.Bedada, R.K.Devarakonda.A simple and
sensitive HPLC method for the determination of Cisplatin(M1005). AAPS Annual
meeting and Expositio, USA, November 16-20, 2008.
4. A.Venkatesham, Y.N.Reddy, P.Narayana, R.K.Devarakonda. Differential
expression of Dipeptidyl Peptidase – IV (DPP-IV) in Asian Indian NIDDM
patient population (T2009). AAPS Annual meeting and Expositio, USA,
November 16-20, 2008.
Papers presented in national conferences:
1. HV.Chauhan , U.Venkatesham , L.Harikiran ,K.Venkateshwar Rao and Y.Narsimha
Reddy. Evaluation of antidiabetic activity of lawsone and its o-alkyl derivatives
(D1086).RIPE-2012,JNTU,Hyderabad,17-18 August,2012.
2. N.Valya, G.Durgaiah, Y.Narsimha Reddy, Ch.Bhanu. Evaluation of antihyperglycemic
and antihyperlipidemic activity of some novel piperonal derivatives (D1083). RIPE2012,JNTU,Hyderabad,17-18 August,2012.
3. Y.Narsimha Reddy,V.Udaykiran,N.Venkata Rajaiah,D.R.Krishna.Apopulation
Pharmacokinetic analysis of losartan in Indian hypertensive patients(PPp16).XXXXIII
Annual
Conference
of
Indian
Pharmacological
Society,Hyderabad,December 13-16,2010.
4. P.Shankaraiah,A.Venkatesham,Y.Narsimha Reddy.Influence of flavonoids on
glucokinase activity in diabetic rats (PPLa-44). XXXXIII Annual Conference of
Indian Pharmacological Society,Hyderabad,December 13-16,2010.
Venkateshwarlu Kodhati, Malla Reddy Vanga and Narsimha Reddy Yellu
(2014).Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New S-mannich Bases
of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones Journal of the Korean Chemical
Society 2013;57(2):234-240.