[BOLUWAJI OGUNYEMI] 1 ELECTRONIC SUBMISSION FOR CONSIDERATION IN THE UNIVERSITY OF TORONTO MEDICAL JOURNAL The Role of Pharmaceutical Companies in the Medicalization of Mental Illness Boluwaji A Ogunyemi1, BSc. 1 Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Phillip Drive, St. John’s, Newfoundland & Labrador, Canada b.ogunyemi@mun.ca ABSTRACT Medicalization refers to when behavior once considered a valid deviation from the norm is subsequently deemed pathological and handled under the purview of medicine. The increasing availability and use of screening tests as well as identification and dissemination of risk and protective factors for disease lends itself to produce the “health-obsessed” society that North America has become. Regarding the etiology of medicalization, critics have pointed their fingers at a number of sources: medical practitioners and the dominance of allopathic medicine have taken a lot of the blame in the past. The medicalization of mental disorders has a history fraught with controversy because diagnosis can often be a function of availability of pharmacological treatment with a concomitant potential for profit. Scientists and clinicians employed specifically by pharmaceutical companies have a heavier hand than one might think in framing what constitutes mental disorders – many of which UTMJ ORIGINAL RESEARCH SUBMISSION Page 1 of 11 Boluwaji Ogunyemi respond reasonably well to the same medication that the companies manufacture. Advertising by multinational pharmaceutical corporations affects the way that society thinks of disease. Considerable portions of the revenue of support groups for particular mental disorders can be traced back to pharmaceutical companies. The dominance of biomedicine as a paradigm as well as changing societal norms have a part to play in the medicalization of mental disorders. Medicalization is a socially-mediated phenomenon and medicalization of psychiatric disease especially so. Political and economic forces temper the way society as a whole sees disease and the role of pharmaceutical companies in the medicalization of mental illness is a prime example of this. KEYWORDS: Medicalization, Psychiatry, Mental Illness MANUSCRIPT Benjamin Franklin [1706-1790] may have had it backwards; rather than necessity being the mother of invention, it seems all too often that the opposite is true. The role of pharmaceutical companies in the medicalization of mental illnesses is largely an example of supply-driven demand in which the providers and creators of medication frame the nature of illness in their favor. Medicalization is a term used to denote the process of otherwise normal behaviour being treated as a medical entity and thus requiring treatment or otherwise taken under the purview of medicine. Medicalization as a phenomenon has been growing rapidly in industrialized countries.. When treated under the scope of medicine, having a “disease” allows for doctors and other health professionals as well as scientists to redefine, re-evaluate and relay information about the condition; since the term medicalization first came into the literature in the 1970’s by Boluwaji Ogunyemi Irving Zola, Peter Conrad and Thomas Szasz. Moynihan et al [12] have it correct when they state that, since the time of the first descriptions of medicalization, the social construction of illness is largely being replaced by the corporate construction of disease. This is especially true of illnesses of psychiatric nature. Medicalization has been increasing with the greater availability of both treatments and drugs. There are considerable economic costs of medicalization, especially with a decline in socialized medical care and pharmacy care. Of course it is precisely the fact that pharmaceutical companies can and have been financially prosperous that it is in their interest to medicalize mental illnesses. Since the 1990’s, pharmaceutical companies have adopted more aggressive corporate strategies through increased mergers-and-acquisitions an increased emphasis of marketing and considerable effort into research-and-development including employing and working with a plethora of scientists and physicians. The latter two points will aid to delineate the ongoing role of pharmaceutical companies in the medicalization of mental illnesses. The medicalization of mental disorders is one of the most widely understood and contentious instances of this phenomenon. The ever-increasing cases in the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM) is a testament to this. Indeed, the DSM has grown from 106 entries in its first publication in 1952 to 364 entries in the current version; DSM IV. (Table 1) UTMJ ORIGINAL RESEARCH SUBMISSION Page 3 of 11 Boluwaji Ogunyemi Table 1: Editions of Diagnostic and Statistical Manual of Mental Disorders DSM Version Year of Publication Number of entries DSM I 1952 106 (130 pages) DSM II 1968 182 DSM III 1980 265 DSM IIIR 1987 292 DSM IV 1994 297 DSM IV TR 2000 365 (886 pages) DSM V May 2013 To be confirmed There are a variety of reasons for the increase between 1952’s DSM I with 106 conditions and the current DSM IV (2008) which enlists 365 conditions; including but not limited to increasingly valid criteria to test for disease, including those of psychiatric origin, increasing ability to recognize abnormal behaviour and/or a biopsychological basis for said behaviour or symptoms. Pharmaceutical companies are not innocent here either; according to Moynihan et al, close to half of the authors that contribute to the expanding DSM versions have had a relationship with a pharmaceutical company at some point. [12] With regard to mental disorders, many critics of medicalization advocate paramedicalization: the replacing of the traditional biomedical approach of medical or clinical emphasis in treatment of illness with a more holistic approach towards attaining health. Paramedicalization includes counselling, meditation and discourse.. Stein et al. relate that with reference to diagnosing cases of ADHD and depression, there is a wealth of data to show that Boluwaji Ogunyemi individuals are suffering from psychological problems and there are some cases that elicit “universal agreement” of interpretation of symptoms. The author then goes on to state that physicians are gaining more awareness of these conditions and that they can be “targeted by modern medical interventions.” It is possible that these “modern medical inventions” are not allowing clinicians to be more “aware” of disease but are actually creating the classification of disease itself. This speaks to the technological imperative; the tendency for physicians to employ new technology when they are available. [5] In The Medicalization of Society, Conrad speaks to the role of publications and those of Paul Wender and Frank Wolkenberg in particular, in the medicalization of adult ADHD. These two spoke of their unfortunate experiences with adult ADHD and reinterpreted their lives before the diagnosis. Later, Dr. Alan Zametkin, a psychiatrist at the National Institute of Mental Health (NIMH) published an article describing how a PET scan confirmed biological differences between victims of adult ADHD and the rest of the “normal” population. (Conrad, 2007) After these publications gained mass readership, adult ADHD clinics were created at Wayne State University in Detroit, MI and at the University of Massachusetts in Worcester. Here, society’s clamour about the “newly discovered” adult ADHD and the growing trend of becoming a riskbased society served in the increasing medicalization of mental illnesses. Many disconfirming studies of Dr. Zametkin’s study were subsequently published, but did not gain mass attention from the media; adult ADHD was already established. [3] It is impossible to ignore the role of pharmaceutical companies in medicalization of mental illness. Ciba-Geigy manufactures Ritalin, which is the most widely-prescribed treatment for ADHD and adult ADHD. Ciba-Geigy provides considerable monetary support organizations that support victims of ADHD. Moreover, “Ciba-Geigy as long been involved in framing hyperactivity and now ADHD as a medical disorder.” [3] In 2005, 22 percent of the support UTMJ ORIGINAL RESEARCH SUBMISSION Page 5 of 11 Boluwaji Ogunyemi group Children and Adults with Attention-Deficit/Hyperactive Disorder’s (CHADD) revenue came from Ciba-Geigy. [3] Pharmaceutical companies have likely played a role in the increases of stimulant use in America from 1995-2005 that has estimated between seven- and nine-fold. [3]. To be sure, the vast majority of cases of psychiatric disease that have been validly diagnosed are genuine and would exist whether or not these corporations exist and therefore in these cases treatment is entirely warranted and appropriate. The phenomenon of medicalization belongs to medical sociology, as it describes those cases and characteristics that are not black and white in terms of disease or non-disease in which society systematically constructs as disease. The same is true for social phobia. Though there are many instances of individuals who suffer from this biopsycholgoical illness, if pharmaceutical companies had their way, almost anyone would suffer from and therefore be able to benefit from treatment from social phobia. The pharmaceutical company Roche promoted an antidepressant named Aurorix (moclobemide) as a treatment for social phobia and the public relations department for this company concomitantly issued a press release, announcing that over a million Australians (of a population of 20 million) were suffering from social phobia. The increase of consumer-directed advertisements in the United States has helped to bolster medicalization of mental illnesses; pharmaceutical companies see individuals more so as consumers than patients. It has been well-documented that advertisements create “wants.” Advertisements that purport that the prevalence of social phobia is high and that individuals will no longer be missing out on valuable relationships if they consider medication for the illness that they have are created by pharmaceutical companies in conjunction with consumer agencies and Boluwaji Ogunyemi medical experts to make as many people as possible believe that they need medication to treat their social phobia. British sociologist Steven Yearley’s Actor-Network Theory provides one explanation for the process of pharmaceutical companies and medicalization of mental disorders. According to said theory, a group of actors or “truth-persuaders” undergo a series of steps to medicalize a phenomenon. This begins with problematization of the condition, followed by using different techniques to construe that a condition is not a valid deviation but indeed a genuine illness. Then, the enrolling of individuals and avenues such as the media to be on the side of the proponent of medicalization and finally mobilizing said parties must occur. [2] This enrolment stage may also include publications to play a large role in the medicalization of Adult ADHD. The media also acts as a significant conduit to which pharmaceutical companies benefit from medicalization. The tenets of this theory are precisely in line with the function of many pharmaceutical corporations. Ceigba-energy promoting ADHD and adult ADHD support groups is an example of problematization- ensuring that awareness of the disease is present. The role of truth persuaders is often taken on by “medical experts.” There are many medical “experts” hired by pharmaceutical companies that will speak to the prevalence of mental illnesses and other diseases. To this end, it has been identified that between a quarter and one half of the psychiatrists that are involved in the publication of the DSM have received part of their income directly from pharmaceutical companies at some point. In both of these ways, medical experts are being recruited to problematize mental illnesses. The media can also be recruited by pharmaceutical companies to in this problematization phase, as described for the case of social phobia. UTMJ ORIGINAL RESEARCH SUBMISSION Page 7 of 11 Boluwaji Ogunyemi As another example, Upjohn and Solvay, a Belgian pharmaceutical company that manufactures Luvox, a psychotropic medication for the treatment of obsessive-compulsive disorder (OCD). This company created brochures to appear in doctors’ offices about the possibility of having obsessive-compulsive disorder and fully funded patient education programs, further intensifying the visibility of obsessive-compulsive disorder. Indeed, the more people think they have disease the more disease will be found. A spokesperson for Glaxo-Smith Kline, one of the giants in research-based pharmaceutics states that "PR [public relations] and media activities are crucial to a well-rounded campaign; particularly in the area of consumer awareness." With the help of medical experts, the media, psychiatrists who write the DSM, consumer groups and a wealth of financial resources, provider-driven demand manifests as pharmaceutical companies promoting the medicalization of mental illness. Yearley’s discussion on risk helps to delineate the fact that we have become a healthobsessed society and the relationship of this to medicalization. [2] Yearley states that modern society has become less focused with the production and allocation of goods and services and more concerned with the ascertaining and decreasing risk to harm. These harms include pollution, the potential of radioactive contamination and of course, medical disease. In Making Sense of Science: Understanding the social study of science, he states that “A society’s risk anxieties relates as much to the cultural ‘insecurities’ of that society as to the actual extent of hazards.” When this insight is applied to medicalization of social phobia, it is arguable that the concern of having social phobia arising from media or other fora that pharmaceutical companies employ may not stand to reason. Boluwaji Ogunyemi Roche has funded a number of conferences of social phobia and in this way stabilized this condition as something that is prevalent and might affect any given person and more importantly, can be treated by Aurorix, a psychotropic drug that Roche so happens to manufacture. Around this time, Roche has hired clinical psychologists to speak to how pharmacotherapy can ameleriorate social phobia. Harry Collins’ [1943 - ] Empirical Program on Relativism is useful in delineating medicalization. The main tenants in the theory are first understanding that scientific results are not absolute but flexible, then analyzing the social processes that are involved with interpretation of said results. The final stage in EPOR is investigating the influence of society as a whole upon the scientists and physicians that both create classification of disease and diagnose. [2] In our case, we find that the technological imperative is at least one value in the medical community that promotes the medicalization of mental illness. Emile Durkheim, one of the founders of sociology, states that society is “external” and “coercive” and indeed it would be remiss to neglect the role of society in defining illness which is in turn coerced by the impact of pharmaceutical companies. [13] UTMJ ORIGINAL RESEARCH SUBMISSION Page 9 of 11 Boluwaji Ogunyemi REFERENCES [1] Kuhn, T. The Structure of Scientific Revolutions. Chicago: University of Chicago Press; 1996. 14-19 pp. [2] Yearley, S. Making Sense of Science: Understanding the social study of science. London: Sage Publications; 2005. [3] Conrad, P. The Medicalization of Society. Baltimore: Johns Hopkins University Press; 2007. [4] Wallace, R. & Wolf, A. Contemporary Sociological Theory: Expanding the Classical Tradition (5th ed) New Jersey: Prentice Hall; 1999. [5] Clarke, J. Health, Illness and Medicine in Canada (4th Ed.) Toronto: Oxford University Press; 2004. [6] Mies, M. Patriarchy and Accumulation on a World Scale. London: Zed Books Limited; 1986. [7] Rudwick, E. W. E. B. Du Bois: Propagandist of the Negro Protest.. New York: Atheneum; 1960. [8] Stein, D, Kaminer, D Zungu-Dirwayi, N. Seedat, S. Pros and cons of medicalization: The example of Trauma. World Journal of Biological 2006. 7:1, 2 – 4. http://informahealthcare.com/doi/abs/10.1080/15622970500483110 [9] Sleep Apnea [Internet]. National Heart Lung & Blood Institute; [cited 2008 April 16] Available from: http://www.nhlbi.nih.gov/health/dci/Diseases/SleepApnea/SleepApnea_WhatIs.html [10] Borderline personality disorder [Internet] National Institute of Mental Health; [cited April 11, 2008 March 11] Available from: http://www.nimh.nih.gov/health/publications/borderline-personality-disorder.shtml Boluwaji Ogunyemi [11] Hu, S, Pattatucci, A, Patterson, C, Li, L, Fulker D, Cherny S., Kruglyak , L, Hamer, D. Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nat. Genet. 1995 11 (3): 248–56. [12] Moynihan, R, Heath, I, Henry, D. Selling sickness: the pharmaceutical industry and disease mongering. BMJ 2002;324:886-891 [13] Poggi, G. Durkheim. Oxford: Oxford University Press; 2000. UTMJ ORIGINAL RESEARCH SUBMISSION Page 11 of 11