TAG Mail 2015 (January - June)
Cumulative Listing of Reports, Publications, Medication Safety Information and
Papers of Interest
________________________________________________________________
TAG Mail 24 June 2015
TAG MEETINGS
Nil
TAG ACTIVITIES
- Surveys
-- Life-Saving Drugs Register Antidote Survey 2015 (closes 30 June 2015)
- Email discussions
-- Guiding principles for the governance of biological and biosimilar medicines
(closes 30 June 2015)
-- Benzodiazepine prescribing to inpatients at high risk of falls (closes 2 July 2015)
-- Tapentadol addition to formulary (closes 9 July 2015)
TAG WEBSITE
Nil
REPORTS AND PUBLICATIONS - AUSTRALIA
**AIHW
-National Bowel Cancer Screening Program: monitoring report 2013-14
http://www.aihw.gov.au/publication-detail/?id=60129551421
-Alcohol and other drug treatment services in Australia 2013-14
http://www.aihw.gov.au/publication-detail/?id=60129551120
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/gardasil-safety-update
**TGA
Update to Prescribing Medicines in Pregnancy database for ledipasavir, asunaprevir,
clonazepam, carmustine
http://www.tga.gov.au/updates-prescribing-medicines-pregnancy-database
REPORTS AND PUBLICATIONS – INTERNATIONAL
**Asthma UK
Patient safety failures in asthma care: the scale of unsafe prescribing in the UK
http://www.asthma.org.uk/patient-safety
**Canadian Agency for Drugs and Technologies in Health (CADTH)
--Rapid Responses: Sedation and Anesthesia Options for Diagnostic Procedures: A
Review of Clinical Effectiveness and Guidelines
https://www.cadth.ca/sedation-and-anesthesia-options-diagnostic-proceduresreview-clinical-effectiveness-and-guidelines
--Reports: Large Volume Crystalloid Fluid Infusion for Adults with Moderate to
Severe Sepsis: Clinical Effectiveness and Guidelines
https://www.cadth.ca/large-volume-crystalloid-fluid-infusion-adults-moderatesevere-sepsis-clinical-effectiveness-and
--Neonatal Vitamin K Administration for the Prevention of Hemorrhagic Disease: A
Review of the Clinical Effectiveness, Comparative Effectiveness, and Guidelines
https://www.cadth.ca/neonatal-vitamin-k-administration-prevention-hemorrhagicdisease-review-clinical-effectiveness
**Cochrane
-Primary prophylaxis for venous thromboembolism in patients undergoing cardiac or
thoracic surgery
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD009658.pub2
-Culturally appropriate health education for people in ethnic minority groups with
type 2 diabetes mellitus
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006424.pub3/abstract;jse
ssionid=1B61C5B51AA1B40CE9EF4D021BB7F87C.f04t01
-Interventions for improving the adoption of shared decision making by healthcare
professionals
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006732.pub3/abstract
**FDA
FDA approves IV antiplatelet drug, cangrelor ‘Kangreal’ used during percutaneous
coronary intervention (PCI)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm452172.htm
**IHI
-Pursuing the Triple Aim: The first seven years. Milbank Quarterly. 2015;93(2):263300.
http://www.ihi.org/resources/Pages/Publications/PursuingTripleAimFirstSevenYear
s.aspx
**MHRA
PPRS Dispute Resolution Panel decisions 2015
https://www.gov.uk/government/publications/pprs-dispute-resolution-paneldecisions-2015
**NICE
Clinical Guidelines
-- Anaemia management in people with chronic kidney disease
http://www.nice.org.uk/guidance/ng8
MEDICATION SAFETY
**New Zealand Health Quality and Safety Commission
-Medication Safety Watch Newsletter
http://www.hqsc.govt.nz/our-programmes/medication-safety/publications-andresources/publication/1751/
**ISMP Medication Safety Alert- Acute Care
Accidental overdoses involving fluorouracil infusions
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=111
**AHRQ
Results of survey on pediatric medication safety—more is needed to protect
hospitalized children from medication errors
http://www.psnet.ahrq.gov/resource.aspx?resourceID=28936
**Health Canada/ Canadian Adverse Reaction Newsletter
--Febuxostat and international reports of agranulocytosis and drug rash with
eosinophilia and systemic symptoms (DRESS).
http://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2015-05-eng.php#s2a
PAPERS OF INTEREST
**Am J Health Syst Pharm
-Medication management for left ventricular assist device thrombosis
http://www.ajhp.org/content/72/13/1104.abstract
-ASHP national survey of pharmacy practice in hospital settings: Dispensing and
administration—2014
http://www.ajhp.org/content/72/13/1119.abstract
-Using lean principles to improve outpatient adult infusion clinic chemotherapy
preparation turnaround times
http://www.ajhp.org/content/72/13/1138.abstract
**Annals of Internal Medicine
Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic
Review for a National Institutes of Health Pathways to Prevention Workshop
Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
http://annals.org/article.aspx?articleid=2322801
**Australian Health Review
-Community representation in hospital decision making: a literature review
http://www.publish.csiro.au/?act=view_file&file_id=AH14016.pdf
-Implementing antimicrobial stewardship in the Australian private hospital system:
a qualitative study
http://www.publish.csiro.au/nid/270/paper/AH14111.htm
-Funding issues and options for pharmacists providing sessional services to rural
hospitals in Australia
http://www.publish.csiro.au/view/journals/dsp_journal_fulltext.cfm?nid=270&f=A
H14081
**BMJ
-Generic immunosuppression in solid organ transplantation: systematic review and
meta-analysis
http://www.bmj.com/content/350/bmj.h3163
-Insulin pump therapy, multiple daily injections, and cardiovascular mortality in
18 168 people with type 1 diabetes: observational study
http://www.bmj.com/content/350/bmj.h3234
-PAin SoluTions In the Emergency Setting (PASTIES)—patient controlled analgesia
versus routine care in emergency department patients with non-traumatic
abdominal pain: randomised trial
http://www.bmj.com/content/350/bmj.h3147
- Safety of lamotrigine in paediatrics: a systematic review
http://bmjopen.bmj.com/content/5/6/e007711.short?g=w_open_current_tab
**BMJ Safety and Quality
-Teamwork, communication and safety climate: a systematic review of
interventions to improve surgical culture
http://qualitysafety.bmj.com/content/24/7/458.abstract
-The association of hospital prevention processes and patient risk factors with the
risk of Clostridium difficile infection: a population-based cohort study
http://qualitysafety.bmj.com/content/24/7/435.abstract
**British Journal of Clin Pharmacology
Meid AD, Lampert A, Burnett A, et al. The impact of pharmaceutical care
interventions for medication underuse in older people: a systematic review and
meta-analysis
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12657/abstract
**Cleveland Clinic – Center for Continuing Education
-Improving medication safety during hospital-based transitions of care
http://www.clevelandclinicmeded.com/online/journal/06_June-2015/0531375/
**Clinical Pediatrics
-Opioid Prescribing and Potential Overdose Errors Among Children 0 to 36 Months
Old
http://cpj.sagepub.com/content/54/8/738
**European Journal of Hospital Pharmacy
-Medication discrepancies revealed by medication reconciliation and their potential
short-term and long-term effects: a Norwegian multicentre study carried out on
internal medicine wards
http://ejhp.bmj.com/content/early/2015/06/19/ejhpharm-2015-000686.abstract
**New England Journal of Medicine
-Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation
http://www.nejm.org/doi/full/10.1056/NEJMoa1501035?query=featured_home
-Idarucizumab for Dabigatran Reversal
http://www.nejm.org/doi/full/10.1056/NEJMoa1502000?query=featured_home
CONSULTATIONS
**TGA
Open consultations and reviews for OTC monograph for ranitidine, mebendazole,
gauifenesin and loperamide; and proposed advisory statements for esomeprazole.
Closing date 10th October, 2014
http://www.tga.gov.au/newsroom/consult-open.htm
OTHER NEWS
Nil
UPCOMING EVENTS (new additions in bold)
**SHPA
Antimicrobial Stewardship Pharmacist Seminar, 23-24 July 2015, Peter Doherty
Institute, Melbourne
http://cpd.shpa.org.au/lib/pdf/conferences/AMS_Pharmacist_Seminar_2015.pdf
**VMIA
Human Factors in Healthcare Forum, 5th August 2015 9.00am-1.00pm, The Alfred,
AMREP Lecture Theatre, 75 Commercial Road, Melbourne
https://www.vmia.vic.gov.au/learn/training-and-development/upcomingprograms/2015/08/05/Human-Factors-in-Healthcare-Forum
Change Champions
Medication Safety and Mental Health, 20 August, Melbourne. Abstracts close 30
June 2015
http://www.changechampions.com.au/call-for-papers
**The Alfred TC-IFEM
The Alfred's 4th Annual International Emergency Care Conference, 26-28 Aug 2015
http://alfredetc-professional-development.cvent.com/events/internationalemergency-care-conference-2015/event-summarydbde3298352b47ffac653eab18bad52e.aspx
**AHRQ
Agency for Healthcare Research and Quality (AHRQ) research conference, 4–6
October, 2015, Crystal City, Virginia USA
Health care research and policy sessions on improving quality, safety, access and
value in health care
http://www.ahrq.gov/news/events/conference/index.html
**ISQUA
'Building Quality and Safety into the Healthcare System', 4-7 October 2015, Doha,
Qatar. Early bird registrations close 15th July 2015
http://www.isqua.org/conference/doha-2015/registration2015?utm_source=Conference+-+Registration+Open++March+2015&utm_campaign=Conference+-+Reg+Open+-
+March+2015&utm_medium=email
*SHPA
Medicines Management 2015, 3-6 December 2015, Melbourne Convention Centre.
Call for abstracts now open - closes Friday 17 July 2015
http://mm2015shpa.com/
TAG Mail 2015 (January - June)
Cumulative Listing of Reports, Publications, Medication Safety
Information and Papers of Interest
TAG Mail 10th June 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**ACSQHC
National Antimicrobial Resistance Strategy 2015-2019
http://www.health.gov.au/internet/main/publishing.nsf/Content/ohp-amr.htm
**AIHW
- Access to health services by Australians with disability 2012
http://www.aihw.gov.au/publication-detail/?id=60129551404
- The health and welfare of Australia’s Aboriginal and Torres Strait Islander
peoples: 2015
http://www.aihw.gov.au/publication-detail/?id=60129550168
- Maternal deaths in Australia 2008–2012
http://www.aihw.gov.au/publication-detail/?id=60129551119
**TGA
New oral anticoagulants - apixaban (Eliquis), dabigatran (Pradaxa) and rivaroxaban
(Xarelto) - No evidence to support routine blood monitoring at this time
http://www.tga.gov.au/alert/new-oral-anticoagulants-apixaban-eliquis-dabigatranpradaxa-and-rivaroxaban-xarelto
REPORTS AND PUBLICATIONS – INTERNATIONAL
**CADTH
- Rapid Response
-- Filtered versus Non-Filtered Needles for Withdrawing Medication from Glass
Ampoules: Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines
https://www.cadth.ca/filtered-versus-non-filtered-needles-withdrawingmedication-glass-ampoules-comparative-clinical
-- Deep Sedation and General Anaesthesia in Young Children: Safety and Guidelines
https://www.cadth.ca/deep-sedation-and-general-anaesthesia-young-childrensafety-and-guidelines
**NICE
- Clinical Guidelines
-- Anaemia management in people with chronic kidney disease
http://www.nice.org.uk/guidance/ng8
-- Lower urinary tract symptoms in men: assessment and management
http://www.nice.org.uk/guidance/cg97
-- Bronchiolitis in children
http://www.nice.org.uk/guidance/ng9
- Technology appraisal
-- Apixaban for the treatment and secondary prevention of deep vein thrombosis
and/or pulmonary embolism
http://www.nice.org.uk/guidance/ta341
-- Obinutuzumab in combination with chlorambucil for untreated chronic
lymphocytic leukaemia
http://www.nice.org.uk/guidance/ta343
-- Ofatumumab in combination with chlorambucil or bendamustine for untreated
chronic lymphocytic leukaemia
http://www.nice.org.uk/guidance/ta344
-- Omalizumab for previously treated chronic spontaneous urticaria
http://www.nice.org.uk/guidance/ta339
-- Ustekinumab for treating active psoriatic arthritis (rapid review of technology
appraisal guidance 313)
http://www.nice.org.uk/guidance/ta340
-- Vedolizumab for treating moderately to severely active ulcerative colitis
http://www.nice.org.uk/guidance/ta342
**SIGN
Management of chronic heart failure; Consultation - draft guidelines
http://www.sign.ac.uk/consultation/index.html
**The Joint Commission
Joint Commission Joins White House Effort to Reduce Antibiotic Overuse
http://www.jointcommission.org/joint_commission_joins_white_house_effort_to_r
educe_antibiotic_overuse/
MEDICATION SAFETY
**ISMP
Part 1: Results of Survey on Pediatric Medication Safety; More is needed to protect
hospitalized children from medication errors
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=110
PAPERS OF INTEREST
**BMJ
- Association between tumour necrosis factor-α inhibitors and risk of serious
infections in people with inflammatory bowel disease: nationwide Danish cohort
study
http://www.bmj.com/content/350/bmj.h2809
- Outcome of delirium in critically ill patients: systematic review and meta-analysis
http://www.bmj.com/content/350/bmj.h2538
**Circulation
Doing the right things and doing them the right way: association between hospital
guideline adherence, dosing safety, and outcomes among patients with acute
coronary syndrome
http://dx.doi.org/10.1161/CIRCULATIONAHA.114.013451
**Eur J Hosp Pharm
Chapter 10: Mentoring and teaching of evidence-based pharmacy
http://ejhp.bmj.com/content/early/2015/06/03/ejhpharm-2015-000713?papetoc
**Infection Control and Hospital Epidemiology
Diagnostic Errors that Lead to Inappropriate Antimicrobial Use
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=97044
23&fileId=S0899823X15001130
**Internal Med J
- Proton pump inhibitors utilisation in older people in New Zealand from 2005 to
2013
http://onlinelibrary.wiley.com/doi/10.1111/imj.12757/abstract
- Medical education and law: withholding/withdrawing treatment from adults
without capacity
http://onlinelibrary.wiley.com/doi/10.1111/imj.12759/abstract
- Is excessive acetaminophen intake associated with transaminitis in adult patients
with dengue fever?
http://onlinelibrary.wiley.com/doi/10.1111/imj.12756/abstract
**NEJM
- Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes
http://www.nejm.org/doi/full/10.1056/NEJMoa1501352?query=featured_home
- Association between edoxaban dose, concentration, anti-Factor Xa activity, and
outcomes: an analysis of data from the randomised, double-blind ENGAGE AF-TIMI
48 trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)619437/abstract
**Pediatrics
A trigger tool to detect harm in pediatric inpatient settings
http://dx.doi.org/10.1542/peds.2014-2152
TAG Mail 3rd June 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**TGA
- The Poisons Standard (the SUSMP) No.7 released
http://www.tga.gov.au/publication/poisons-standard-susmp
- AusPARS added Elosulfase alfa (rch) (Vimizim) and Fentanyl citrate (Fentora)
http://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars
REPORTS AND PUBLICATIONS – INTERNATIONAL
**FDA
- FDA approves Rapamune (sirolimus) to treat LAM, a very rare lung disease
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm448523.htm
- FDA approves two therapies to treat IBS-D, Viberzi (eluxadoline) and Xifaxan
(rifaximin)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm448328.htm
MEDICATION SAFETY
**Health Canada
Febuxostat and international reports of agranulocytosis and drug rash with
eosinophilia and systemic symptoms (DRESS)
http://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2015-05-eng.php#s2a
**HQSCNZ
Medication Safety Watch newsletter, May 2015 includes: Human factors or
ergonomics and medication safety | One steps for medication safety | Opioids
collaborative update | Decimal points and other error prone abbreviations in
electronic systems | Insulin 500 units/mL (Humulin R® U-500 units/mL)
http://www.hqsc.govt.nz/our-programmes/medication-safety/publications-andresources/publication/2176/
**TGA
- Medicines Safety Update June 2015 includes: Methotrexate and hepatitis B
reactivation | Ivabradine and cardiovascular events in patients with angina |
Ethinylestradiol/etonogestrel vaginal ring and thromboembolic risk
http://www.tga.gov.au/publication-issue/medicines-safety-update-volume-6number-3-june-2015
- Medicines and vaccines post-market vigilance - statistics for 2014
http://www.tga.gov.au/medicines-and-vaccines-post-market-vigilance-statistics2014
- Medtronic Australasia - US consent decree on SynchroMed drug infusion system
https://www.tga.gov.au/media-release/medtronic-australasia-us-consent-decreesynchromed-drug-infusion-system
PAPERS OF INTEREST
**Am J Health-Syst Pharm
- Clostridium difficile infection: A brief update on emerging therapies
http://www.ajhp.org/content/72/12/1007.abstract
- Role of intravenous immune globulin in streptococcal toxic shock syndrome and
Clostridium difficile infection
http://www.ajhp.org/content/72/12/1013.abstract
- Clinical outcomes and treatment cost comparison of levalbuterol versus albuterol
in hospitalized adults with chronic obstructive pulmonary disease or asthma
http://www.ajhp.org/content/72/12/1026.abstract
**Aust Prescriber
Prescribing azithromycin
http://www.australianprescriber.com/magazine/38/3/87/9
**BMJ
Varenicline and risk of psychiatric conditions, suicidal behaviour, criminal
offending, and transport accidents and offences: population based cohort study
http://www.bmj.com/content/350/bmj.h2388
**BMJ Open
Computerised clinical decision support systems to improve medication safety in
long-term care homes: a systematic review
http://bmjopen.bmj.com/content/5/5/e006539
**BMJ Qual Saf
A unit-based intervention aimed at improving patient adherence to pharmacological
thromboprophylaxis
http://qualitysafety.bmj.com/content/early/2015/06/02/bmjqs-2015003992.short?g=w_qs_ahead_tab
**Br J Clin Pharmacol
- Liver injury with novel oral anticoagulants: assessing post-marketing reports in the
US Food and Drug Administration adverse event reporting system
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12611/abstract
- A population-based study of the drug interaction between clopidogrel and
angiotensin converting enzyme inhibitors
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12682/abstract
**Cochrane
Incentives for smoking cessation
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD004307.pub5
Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS)
versus addition of long-acting beta2-agonists (LABA) for adults with asthma
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD011438.pub2
**JAMA
Antidepressant Use Late in Pregnancy and Risk of Persistent Pulmonary
Hypertension of the Newborn
http://jama.jamanetwork.com/article.aspx?articleid=2300602
**JAMA Intern Med
Efficacy and Safety of Single-Dose Zoledronic Acid for Osteoporosis in Frail Elderly
Women: A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2247163
Rates of Opioid Dispensing and Overdose After Introduction of Abuse-Deterrent
Extended-Release Oxycodone and Withdrawal of Propoxyphene
http://archinte.jamanetwork.com/article.aspx?articleid=2276923
Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and
Mortality in Older Nursing Home Residents: The PARTAGE Study
http://archinte.jamanetwork.com/article.aspx?articleid=2110995
**Pharmacoepidemiol Drug Saf
Are ECG monitoring recommendations before prescription of QT-prolonging drugs
applied in daily practice? The example of haloperidol
http://onlinelibrary.wiley.com/doi/10.1002/pds.3792/abstract
**Prescrire International
Dabigatran (Pradaxa°) in deep vein thrombosis and pulmonary embolism
http://english.prescrire.org/en/81/168/49953/0/NewsDetails.aspx
TAG Mail 27th May 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**AIHW
Development of a national education and training data standards strategy and
implementation plan
http://www.aihw.gov.au/publication-detail/?id=60129551063
**TGA
- TGA presentation given at the Sydney Children's Hospital Network Research
Governance, 31 March 2015 - an overview of the TGA's role in controlling access to
unapproved therapeutic goods, including in clinical trials
http://www.tga.gov.au/tga-presentation-given-sydney-childrens-hospital-networkresearch-governance-31-march-2015
- Information for registered users of the Australian Adverse Drug Reaction Reporting
System
http://www.tga.gov.au/information-registered-users-australian-adverse-drugreaction-reporting-system
- Natalizumab and melanoma; Final update - no definite link established
http://www.tga.gov.au/monitoring-communication/natalizumab-and-melanoma
REPORTS AND PUBLICATIONS – INTERNATIONAL
**EMA
- First-in-class treatment to lower cholesterol; EMA has recommended authorising
Repatha (evolocumab)
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/05/news_detail_002336.jsp&mid=WC0b01ac058004d5c1
- New treatment option recommended for patients with advanced melanoma,
Keytruda (pembrolizumab)
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/05/news_detail_002334.jsp&mid=WC0b01ac058004d5c1
- New treatment option for patients with advanced lung cancer, Nivolumab BMS
(nivolumab)
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/05/news_detail_002335.jsp&mid=WC0b01ac058004d5c1
- EMA recommends treatment for rare cancer in children, Unituxin (dinutuximab)
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/05/news_detail_002333.jsp&mid=WC0b01ac058004d5c1
- EMA recommends Imbruvica (ibrutinib) for the treatment of Waldenstrӧm’s
macroglobulinaemia, Imbruvica (ibrutinib)
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/05/news_detail_002332.jsp&mid=WC0b01ac058004d5c1
**Health Improvement Scotland-NHS boards and Area DTCs
Biosimilar medicines: A national prescribing framework
http://www.healthcareimprovementscotland.org/our_work/technologies_and_med
icines/programme_resources/biosimilar_medicines_framework.aspx
MEDICATION SAFETY
**EMA
Updated advice on use of high-dose ibuprofen
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/05/news_detail_002337.jsp&mid=WC0b01ac058004d5c1
**FDA
- FDA Drug Safety Communication: FDA cautions about dose confusion and
medication errors for antibacterial drug Zerbaxa (ceftolozane and tazobactam)
http://www.fda.gov/Drugs/DrugSafety/ucm445919.htm
- FDA Drug Safety Podcast: FDA warns that SGLT2 inhibitors for diabetes may result
in a serious condition of too much acid in the blood
http://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm447651.htm
**ISMP
The absence of a drug-disease interaction alert leads to a child’s death
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=109
**MHRA
-Drug Safety Update, May 2015
-- Sofosbuvir with daclatasvir; sofosbuvir and ledipasvir: risks of severe bradycardia
and heart block when taken with amiodarone
https://www.gov.uk/drug-safety-update/sofosbuvir-with-daclatasvir-sofosbuvirand-ledipasvir-risks-of-severe-bradycardia-and-heart-block-when-taken-withamiodarone
-- Pomalidomide (Imnovid▼): risks of cardiac failure, interstitial lung disease and
hepatotoxicity
https://www.gov.uk/drug-safety-update/pomalidomide-imnovid-risks-of-cardiacfailure-interstitial-lung-disease-and-hepatotoxicity
-- Epoetin beta (NeoRecormon): increased risk of retinopathy in preterm infants
cannot be excluded
https://www.gov.uk/drug-safety-update/epoetin-beta-neorecormon-increasedrisk-of-retinopathy-in-preterm-infants-cannot-be-excluded
-- Fingolimod (▼Gilenya): first reported case of progressive multifocal
leukoencephalopathy in a multiple sclerosis patient taking fingolimod
https://assets.digital.cabinetoffice.gov.uk/media/555c338ced915d7ae5000007/Gilenya_DHPC_sent_29_April.pdf
-- Topical ketoprofen and risk of photosensitivity reactions: reminder of risk
minimisation measures
https://assets.digital.cabinetoffice.gov.uk/media/555c335ce5274a74ca000009/Ketoprofen_DHPC_sent_20-042015.pdf
**NPS-MedicineWise
Reducing paracetamol misuse
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/reducing-paracetamol-misuse
PAPERS OF INTEREST
**Ann Intern Med
- Longer Versus Shorter Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent
Placement: A Systematic Review and Meta-analysis
http://annals.org/article.aspx?articleid=2297227
- Development of an "infusion pump safety score"
http://dx.doi.org/10.2146/ajhp140421
**BMJ
Use of combined oral contraceptives and risk of venous thromboembolism: nested
case-control studies using the QResearch and CPRD databases
http://www.bmj.com/content/350/bmj.h2135
**Circulation
Efficacy and Harms of Direct Oral Anticoagulants in the Elderly for Stroke
Prevention in Atrial Fibrillation and Secondary Prevention of Venous
Thromboembolism: Systematic Review and Meta-Analysis
http://circ.ahajournals.org/content/early/2015/05/15/CIRCULATIONAHA.114.0132
67.abstract
**Clin Transplant
Safety and efficacy of the switch to generic mycophenolate mofetil and tacrolimus
in heart-transplant patients
http://www.ncbi.nlm.nih.gov/pubmed/25981927
**Eur J Hosp Pharm
- A 2-year retrospective review of vial sharing options for the compounding of
cytotoxics
http://ejhp.bmj.com/content/22/3/161.abstract
- Evaluation of eight drug interaction databases commonly used in the German
healthcare system
http://ejhp.bmj.com/content/22/3/165.abstract
**JAMA
Stroke Prevention in Atrial Fibrillation: A Systematic Review
http://jama.jamanetwork.com/article.aspx?articleid=2293300
**JAMA Internal Medicine
Tools to Promote Shared Decision Making in Serious Illness: A Systematic Review
http://archinte.jamanetwork.com/article.aspx?articleid=2294238
**JAMA Opthalmology
Risk of Substantial Intraocular Bleeding With Novel Oral Anticoagulants: Systematic
Review and Meta-analysis
http://archinte.jamanetwork.com/article.aspx?articleid=2294238
**J Thromb Thrombolysis
Chemical prophylaxis to prevent venous thromboembolism in morbid obesity:
literature review and dosing recommendations
http://www.ncbi.nlm.nih.gov/pubmed/25982217
**Lancet
- Comparative efficacy and safety of blood pressure-lowering agents in adults with
diabetes and kidney disease: a network meta-analysis
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)624594/abstract
- Once-weekly dulaglutide versus bedtime insulin glargine, both in combination with
prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): a randomised,
open-label, phase 3, non-inferiority study
http://www.thelancet.com/journals/lancet/issue/current
- Heart failure and mortality outcomes in patients with type 2 diabetes taking
alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
http://www.thelancet.com/journals/lancet/issue/current
- Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K
antagonist reversal in patients needing urgent surgical or invasive interventions: a
phase 3b, open-label, non-inferiority, randomised trial
http://www.thelancet.com/journals/lancet/issue/current
**Lancet –Haematology
Fiix-prothrombin time versus standard prothrombin time for monitoring of warfarin
anticoagulation: a single centre, double-blind, randomised, non-inferiority trial
http://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(15)000733/abstract
**NEJM
Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection
http://www.nejm.org/doi/full/10.1056/NEJMoa1411162?query=featured_home
TAG Mail 20th May 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**AIHW
- Incidence of type 1 diabetes in Australia 2000–2013
http://www.aihw.gov.au/publication-detail/?id=60129550890
- The nKPI data collection: data quality issues working paper
http://www.aihw.gov.au/publication-detail/?id=60129551074
- Back problems: musculoskeletal fact sheet
http://www.aihw.gov.au/publication-detail/?id=60129551044
- Osteoarthritis: musculoskeletal fact sheet
http://www.aihw.gov.au/publication-detail/?id=60129551049
**NHMRC
NHMRC Statement and Information Paper: Evidence on the Effects of Lead on
Human Health
http://www.nhmrc.gov.au/guidelines-publications/eh58
REPORTS AND PUBLICATIONS – INTERNATIONAL
**NICE
- Eyes on Evidence (NB Links bring up a PDF)
-- Intermittent versus continuous administration of proton pump inhibitors after
treatment of bleeding ulcers
-http://arms.evidence.nhs.uk/resources/hub/1044001/attachment
-- Nicotine replacement therapy for people trying to cut down cigarette use
http://arms.evidence.nhs.uk/resources/hub/1044003/attachment
-- Patients’ expectations of the benefits and harms of treatments and tests
http://arms.evidence.nhs.uk/resources/hub/1044011/attachment
**SIGN
SIGN 143: Diagnosis and management of epilepsy in adults
http://www.sign.ac.uk/pdf/SIGN143.pdf
**WHO
World Health Statistics 2015
http://www.who.int/publications/en/
MEDICATION SAFETY
**AHRQ
Patient Safety Primers - guide you through key concepts in patient safety
http://psnet.ahrq.gov/primerHome.aspx
**FDA
FDA Drug Safety Communication: FDA warns that SGLT2 inhibitors (canagliflozin,
dapagliflozin, and empagliflozin) for diabetes may result in a serious condition of
too much acid in the blood (ketoacidosis)
http://www.fda.gov/Drugs/DrugSafety/ucm446845.htm
**TGA
- Gardasil (quadrivalent human papillomavirus vaccine), update 2
http://www.tga.gov.au/alert/gardasil-quadrivalent-human-papillomavirus-vaccineupdate-2
- Enhanced school-based surveillance of acute adverse events following
immunisation with human papillomavirus vaccine in males and females, 2013
http://www.tga.gov.au/enhanced-school-based-surveillance-acute-adverse-eventsfollowing-immunisation-human-papillomavirus-vaccine-males-and-females-2013
PAPERS OF INTEREST
**Am J Health-Syst Pharm
- Role of obinutuzumab in the treatment of chronic lymphocytic leukemia
http://www.ajhp.org/content/72/11/933.abstract
- Potential cytochrome P-450 drug–drug interactions in adults with metastatic solid
tumors and effect on eligibility for Phase I clinical trials
http://www.ajhp.org/content/72/11/958.abstract
**BMJ
- Primary prevention with lipid lowering drugs and long term risk of vascular events
in older people: population based cohort study
http://www.bmj.com/content/350/bmj.h2335
- Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused
by meticillin resistant Staphylococcus aureus: randomised controlled trial
http://www.bmj.com/content/350/bmj.h2219
- Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence
syndrome: population based cohort study
http://www.bmj.com/content/350/bmj.h2102
- Antipsychotic drug use in pregnancy: high dimensional, propensity matched,
population based cohort study
http://www.bmj.com/content/350/bmj.h2298
**Eur J Hosp Pharm
Drug-related problems in a clinical setting: a literature review and cross-sectional
study evaluating factors to identify patients at risk
http://ejhp.bmj.com/content/early/2015/05/15/ejhpharm-2014-000605?papetoc
** JAMA
- Oral steroids for Acute Radiculopathy Due to a Herniated Lumbar Disk
http://jama.jamanetwork.com/article.aspx?articleid=2293294
**JAMA Internal Medicine
- Exercise and Vitamin D in Fall Prevention Among Older Women A Randomized
Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2204033
**J Clin Endocrinol Metab
Comparative Resistance to Teriparatide-Induced Bone Resorption with Denosumab
or Alendronate
http://www.ncbi.nlm.nih.gov/pubmed/25933031
**J Patient Saf
The trigger tool as a method to measure harmful medication errors in children
http://www.ncbi.nlm.nih.gov/pubmed/25853805
**Lancet
- Risk of serious infection in biological treatment of patients with rheumatoid
arthritis: a systematic review and meta-analysis
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)617049/abstract
- Does antiretroviral therapy reduce HIV-associated tuberculosis incidence to
background rates? A national observational cohort study from England, Wales, and
Northern Ireland
http://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(15)000636/abstract
- Ceftolozane-tazobactam compared with levofloxacin in the treatment of
complicated urinary-tract infections, including pyelonephritis: a randomised,
double-blind, phase 3 trial (ASPECT-cUTI)
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)622200/abstract
- Optimum and stepped care standardised antihypertensive treatment with or
without renal denervation for resistant hypertension (DENERHTN): a multicentre,
open-label, randomised controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)619425/abstract
- Worldwide access to treatment for end-stage kidney disease: a systematic review
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)616019/abstract
**MJA
- Asthma control in Australia: a cross-sectional web-based survey in a nationally
representative population
https://www.mja.com.au/system/files/issues/red01564.pdf
**Pediatrics
- Effectiveness of Pediatric Pill Swallowing Interventions: A Systematic Review
http://pediatrics.aappublications.org/content/135/5/883.abstract
- Nicotine Replacement Therapy in Pregnancy and Major Congenital Anomalies in
Offspring
http://pediatrics.aappublications.org/content/135/5/859.abstract
- Prescription Opioid Epidemic and Infant Outcomes
http://pediatrics.aappublications.org/content/135/5/842.abstract
- Cost-Effectiveness of Treatment of Acute Otorrhea in Children With
Tympanostomy Tubes
http://pediatrics.aappublications.org/content/135/5/e1182.abstract
TAG Mail 13th May 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**TGA
- Orphan drugs added: Pegaspargase (ONCASPAR)
http://www.tga.gov.au/updates-list-designated-orphan-drugs
- Updates to the prescribing medicines in pregnancy database
http://www.tga.gov.au/updates-prescribing-medicines-pregnancy-database
REPORTS AND PUBLICATIONS – INTERNATIONAL
**CADTH
- Continuous versus Intermittent Intravenous Pantoprazole for Acute
Gastrointestinal Bleeding: A Review of the Clinical Effectiveness and Guidelines
https://www.cadth.ca/continuous-versus-intermittent-intravenous-pantoprazoleacute-gastrointestinal-bleeding-review
- Compounded Diclofenac Cream for Topical Anti-Inflammatory Treatment: Clinical
and Cost-Effectiveness, and Guidelines
https://www.cadth.ca/compounded-diclofenac-cream-topical-anti-inflammatorytreatment-clinical-and-cost-effectiveness-and
- Treatment of Older Adults with Insomnia, Agitation, or Delirium with
Benzodiazepines: Clinical Effectiveness and Guidelines
https://www.cadth.ca/treatment-older-adults-insomnia-agitation-or-deliriumbenzodiazepines-clinical-effectiveness-and
- Bisphosphonate Use in Patients with Osteopenia and Low Risk of Fractures:
Clinical Effectiveness and Guidelines
https://www.cadth.ca/bisphosphonate-use-patients-osteopenia-and-low-riskfractures-clinical-effectiveness-and-guidelines
**FDA
FDA approves additional antibacterial treatment for plague, Avelox (moxifloxacin)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm446283.htm
**GOV.UK
A number of government policy reports were collated on the day of the British
election last week covering dementia, patient safety, cancer research and
treatment, mental health servcie reform, children's health, longterm health
conditions
https://www.gov.uk/government/publications?keywords=&publication_filter_optio
n=all&topics%5B%5D=national-health-service&departments%5B%5D=department-ofhealth&official_document_status=all&world_locations%5B%5D=all&from_date=&to_
date=&commit=Refresh+results
MEDICATION SAFETY
**EMA
- Safety monitoring of medicines: EMA to screen medical literature for 400 active
substance groups
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/05/news_detail_002325.jsp&mid=WC0b01ac058004d5c1
- Reviews of Tysabri (natalizumab) and inhaled corticosteroids used to treat chronic
obstructive pulmonary disease started
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/05/news_detail_002323.jsp&mid=WC0b01ac058004d5c1
**ISMP
QuarterWatch™ 2014 Quarter 2: Zolpidem and canagliflozin safety signals,
thousands of incomplete rosiglitazone reports
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=108
PAPERS OF INTEREST
**BMJ Qual Saf
- Intended and unintended effects of large-scale adverse event disclosure: a
controlled before-after analysis of five large-scale notifications
http://qualitysafety.bmj.com/content/24/5/295.full
- Developing person-centred analysis of harm in a paediatric hospital: a quality
improvement report
http://qualitysafety.bmj.com/content/24/5/337.full
**Cochrane
Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine
reuptake inhibitors (SNRIs) for the prevention of tension-type headache in adults
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD011681/
**Int J Pharm Prac
The four or more medicines (FOMM) support service: results from an evaluation of a
new community pharmacy service aimed at over-65s
http://onlinelibrary.wiley.com/doi/10.1111/ijpp.12196/abstract
**Intern Med J
- Comparison of the management and in-hospital outcomes of acute coronary
syndrome patients in Australia and New Zealand: results from the binational
SNAPSHOT acute coronary syndrome 2012 audit
http://onlinelibrary.wiley.com/doi/10.1111/imj.12739/abstract
- Safety of coadministration of ezetimibe and statins in patients with
hypercholesterolaemia: a meta-analysis
http://onlinelibrary.wiley.com/doi/10.1111/imj.12706/abstract
- Consensus guidelines for the investigation and management of encephalitis in
adults and children in Australia and New Zealand
http://onlinelibrary.wiley.com/doi/10.1111/imj.12749/abstract
**JAMIA
- Towards creating the perfect electronic prescription
http://jamia.oxfordjournals.org/content/22/e1/e7
- Comparative outcome studies of clinical decision support software: limitations to
the practice of evidence-based system acquisition
http://jamia.oxfordjournals.org/content/22/e1/e13
- Impact of clinical decision support preventing the use of QT-prolonging
medications for patients at risk for torsade de pointes
http://jamia.oxfordjournals.org/content/22/e1/e21
- Medical student awareness of and interest in clinical informatics
http://jamia.oxfordjournals.org/content/22/e1/e42
**Joint Commission Journal on Patient Safety and Quality
Methods for Reducing Sepsis Mortality in Emergency Departments and Inpatient
Units
http://www.ingentaconnect.com/content/jcaho/jcjqs/2015/00000041/00000005/a
rt00003
**Lancet
Brentuximab vedotin as consolidation therapy after autologous stem-cell
transplantation in patients with Hodgkin's lymphoma at risk of relapse or
progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3
trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)601659/abstract
**NEJM
Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction
http://www.nejm.org/doi/full/10.1056/NEJMoa1500857
**Western Journal of Nursing Rresearch
Nurses’ Use of Computerized Clinical Guidelines to Improve Patient Safety in
Hospitals
http://wjn.sagepub.com/content/early/2015/03/26/0193945915577430
TAG Mail 6th May 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**AIHW
Respiratory medication use in Australia 2003–2013: treatment of asthma and COPD
http://www.aihw.gov.au/publication-detail/?id=60129550778
**NPS-MedicineWise
Antihypertensives in pregnancy
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/antihypertensives-in-pregnancy
**NSW Health
Updated Application Forms for Authority to Prescribe Pharmacotherapies
http://www0.health.nsw.gov.au/policies/ib/2015/IB2015_018.html
**TGA
- Recall:
-- DBL Methotrexate 2.5mg tablets in bottles of 30 - bottles supplied without childresistant caps
http://www.tga.gov.au/alert/methotrexate-dbl-methotrexate-tablets-25-mgtablets-bottles-30
- Medicine shortages:
-- Ampicillin injection and Amoxycillin injection
http://www.tga.gov.au/alert/ampicillin-injection-and-amoxycillin-injectionmedicine-shortages
-- IMMUCYST® BCG and ONCOTICE® (Bacillus Calmette and Guerin)
http://www.tga.gov.au/alert/immucystr-bcg-and-oncoticer-bacillus-calmette-andguerin-medicine-shortages
REPORTS AND PUBLICATIONS – INTERNATIONAL
**GOV.UK
EAGA guidance on HIV post-exposure prophylaxis
https://www.gov.uk/government/publications/eaga-guidance-on-hiv-postexposure-prophylaxis
**FDA
FDA approves treatment, Kybella (deoxycholic acid), for fat below the chin
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm444978.htm
MEDICATION SAFETY
**Health Canada
Health Product InfoWatch - April 2015 includes: Goldenseal and cytochrome P450
inhibition; Attention Deficit Hyperactivity Disorder (ADHD) Drugs
http://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2015-04-eng.php#s1c
**MHRA
- Hydroxyzine (Atarax, Ucerax): risk of QT interval prolongation and Torsade de
Pointes
https://www.gov.uk/drug-safety-update/hydroxyzine-atarax-ucerax-risk-of-qtinterval-prolongation-and-torsade-de-pointes
- Codeine for cough and cold: restricted use in children
https://www.gov.uk/drug-safety-update/codeine-for-cough-and-cold-restricteduse-in-children
- High strength, fixed combination and biosimilar insulin products: minimising the
risk of medication error
https://www.gov.uk/drug-safety-update/high-strength-fixed-combination-andbiosimilar-insulin-products-minimising-the-risk-of-medication-error
- Ketoconazole HRA: information about the risk of hepatotoxicity
https://assets.digital.cabinetoffice.gov.uk/media/5537a3d740f0b6158900002f/Ketoconazole_DHPC_sent_24_Mar
ch_2015.pdf
PAPERS OF INTEREST
**Acta Psychiatr Scand
Clozapine-induced myocarditis, a widely overlooked adverse reaction
http://www.ncbi.nlm.nih.gov/pubmed/25865238
**Am J Health-Syst Pharm
- Development of an “infusion pump safety score”
http://www.ajhp.org/content/72/10/777.full
- Assessing pharmacologic and nonpharmacologic risks in candidates for kidney
transplantation
http://www.ajhp.org/content/72/10/781.abstract
**JAMA Intern Med
- Evaluation of Stepped Care for Chronic Pain (ESCAPE) in Veterans of the Iraq and
Afghanistan Conflicts: A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2174941
- Safety and Benefit of Discontinuing Statin Therapy in the Setting of Advanced,
Life-Limiting Illness: A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2204034
- Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and
Meta-analysis Incorporating Individual Patient Data
http://archinte.jamanetwork.com/article.aspx?articleid=2195120
- Continuous Proton Pump Inhibitor Therapy and the Associated Risk of Recurrent
Clostridium difficile Infection
http://archinte.jamanetwork.com/article.aspx?articleid=2173095
**JAMIA
Tailoring of alerts substantially reduces the alert burden in computerized clinical
decision support for drugs that should be avoided in patients with renal disease
http://jamia.oxfordjournals.org/content/early/2015/04/21/jamia.ocv027
**Lancet
- Oseltamivir treatment for influenza in adults: a meta-analysis of randomised
controlled trials
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)624491/abstract
- Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824),
and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase
2b, open-label, partly randomised trial in patients with drug-susceptible or drugresistant pulmonary tuberculosis
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)62002X/abstract
- Simplified antibiotic regimens compared with injectable procaine benzylpenicillin
plus gentamicin for treatment of neonates and young infants with clinical signs of
possible serious bacterial infection when referral is not possible: a randomised,
open-label, equivalence trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)622844/abstract
**MJA
A prospective cohort study of trends in self-poisoning, Newcastle, Australia, 1987–
2012: plus ça change, plus c’est la même chose
https://www.mja.com.au/journal/2015/202/8/prospective-cohort-study-trendsself-poisoning-newcastle-australia-1987-2012-plus
TAG Mail 29th April 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**ACSQHC
Guide to the National Safety and Quality Health Service Standards for health service
organisation boards, April 2015
http://www.safetyandquality.gov.au/publications/guide-to-the-national-safetyand-quality-health-service-standards-for-health-service-organisation-boards-april2015/
**AIHW
Alcohol and Other Drug Treatment Services in Australia 2013-14 collection and
reporting
http://www.aihw.gov.au/media-release-detail/?id=60129550783
**TGA
- AusPARS added: Remestemcel-L, ex vivo adult human mesenchymal stem cells
(Prochymal)S
http://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars
- Accu-Chek Spirit Combo and Accu-Chek Spirit insulin pumps
http://www.tga.gov.au/alert/accu-chek-spirit-combo-and-accu-chek-spirit-insulinpumps
REPORTS AND PUBLICATIONS – INTERNATIONAL
**CADTH
Gabapentin for Adults with Neuropathic Pain: A Review of the Clinical Efficacy and
Safety
https://www.cadth.ca/gabapentin-adults-neuropathic-pain-review-clinicalefficacy-and-safety-0
- Combination Benzodiazepine-Opioid Use: Clinical Evidence and Guidelines
https://www.cadth.ca/combination-benzodiazepine-opioid-use-clinical-evidenceand-guidelines-0
- Angiotensin Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker
Combination Therapy: Harms and Guidelines
https://www.cadth.ca/angiotensin-converting-enzyme-inhibitor-and-angiotensin-iireceptor-blocker-combination-therapy
- Non-Steroidal Anti-Inflammatory Drugs in Patients with Hypertension, Chronic
Kidney Disease, or Heart Failure: Benefits, Harms, and Guidelines
https://www.cadth.ca/non-steroidal-anti-inflammatory-drugs-patientshypertension-chronic-kidney-disease-or-heart-failure
**EMA
New treatment for advanced melanoma: Opdivo (nivolumab) offers treatment
option for patients with poor prognosis
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/04/news_detail_002314.jsp&mid=WC0b01ac058004d5c1
**FDA
FDA approves first generic Abilify (aripiprazole) to treat mental illnesses
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm444862.htm
**NICE
Chronic obstructive pulmonary disease: aclidinium/formoterol [ESNM57]
http://www.nice.org.uk/advice/esnm57
MEDICATION SAFETY
**EMA
- EMA recommends avoidance of certain hepatitis C medicines and amiodarone
together: Concomitant use may increase risk of slow heart rate and related
problems
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/04/news_detail_002313.jsp&mid=WC0b01ac058004d5c1
- Codeine not to be used in children below 12 years for cough and cold
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/04/news_detail_002316.jsp&mid=WC0b01ac058004d5c1
**GOV.UK
Dimethyl fumarate (Tecfidera): fatal PML in an MS patient with severe, prolonged
lymphopenia
https://www.gov.uk/drug-safety-update/dimethyl-fumarate-tecfidera-fatal-pml-ina-ms-patient-with-severe-prolonged-lymphopenia
**ISMP
- Life-threatening errors with flecainide suspension in children
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=107
- You are invited to take part in a Measurement Survey to Create a Meaningful
Medication Safety Dashboard
http://surveys.ismp.org/s3/Measurement-Matters-ISMP
PAPERS OF INTEREST
**Am J Health-Syst Pharm
ASHP Guidelines on Preventing Medication Errors with Chemotherapy and
Biotherapy
http://www.ajhp.org/content/72/8/e6?hw-tma-check=true
**Ann Intern Med
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With
Hypercholesterolemia: A Systematic Review and Meta-analysis
http://annals.org/article.aspx?articleid=2279798
**BMJ
- Comparative risk of gastrointestinal bleeding with dabigatran, rivaroxaban, and
warfarin: population based cohort study
http://www.bmj.com/content/350/bmj.h1857
- with Editorial: Safety of new oral anticoagulants
http://www.bmj.com/content/350/bmj.h1679
- Risk of gastrointestinal bleeding associated with oral anticoagulants: population
based retrospective cohort study
http://www.bmj.com/content/350/bmj.h1585
**Cochrane
Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine
reuptake inhibitors (SNRIs) for the prevention of migraine in adults
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002919.pub3/abstract
**Eur J Hosp Pharm
- Is a POMMP approach the way to move the medication safety agenda forward in
your organisation
http://ejhp.bmj.com/content/22/3/127.full
- A cohort study investigating medication management by pharmacists to prevent
drug-related problems in pain therapy
http://ejhp.bmj.com/content/22/3/156.full
- Impact of educational interventions on the physicians for early switchover of
parenteral drugs to oral therapy
http://ejhp.bmj.com/content/22/3/176.abstract
- Safety and effectiveness of the combination acetazolamide and bicarbonates to
induce alkaline diuresis in patients with rhabdomyolysis
http://ejhp.bmj.com/content/early/2015/04/26/ejhpharm-2014000577.short?g=w_ejhp_ahead_tab
**Health Policy
How to make medication error reporting systems work—factors associated with
their successful development and implementation
http://dx.doi.org/10.1016/j.healthpol.2015.03.002
**JAMA
- Effect of a Retrievable Inferior Vena Cava Filter Plus Anticoagulation vs
Anticoagulation Alone on Risk of Recurrent Pulmonary Embolism: A Randomized
Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2279714
- Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid
Dependence: A Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2279713
**JAMA Intern Med
Long-term Nicotine Replacement Therapy: A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2167116
**Lancet
Rituximab as second-line treatment for adult immune thrombocytopenia (the RITP
trial): a multicentre, randomised, double-blind, placebo-controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)614951/abstract
**NEJM
Prednisolone or Pentoxifylline for Alcoholic Hepatitis
http://www.nejm.org/doi/full/10.1056/NEJMoa1412278
**Neurology
Evidence-based guideline: Management of an unprovoked first seizure in adults
http://www.neurology.org/content/84/16/1705.full.pdf+html
TAG Mail 22nd April 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**AIHW
National opioid pharmacotherapy statistics (NOPSAD)
http://www.aihw.gov.au/alcohol-and-other-drugs/nopsad/
**NHMRC
NHMRC CEO Statement: Electronic cigarettes (e-cigarettes)
http://www.nhmrc.gov.au/guidelinespublications/ds13?utm_medium=email&utm_campaign=NHMRC%20Health%20Tracker
%20-%20April%202015&utm_content=NHMRC%20Health%20Tracker%20%20April%202015+CID_74cc15005da49da4722ef405e5004ed5&utm_source=Mailbuild
&utm_term=NHMRC%20website
**National Asthma Council Australia
Australian Asthma Handbook, updated version released
http://www.nationalasthma.org.au/news-media/d/2015-04-16/updated-asthmahandbook-released
**NPS-MedicineWise
- NPS RADAR April 2015 includes
-- Ranibizumab (Lucentis) and aflibercept (Eylea) for ocular indications
-- Aripiprazole modified release (Abilify Maintena) for schizophrenia
-- Dapagliflozin (Forxiga) with insulin, an option for type 2 diabetes add-on
treatment
-- Sensipar (cinacalcet) PBS listing to be deleted
http://www.nps.org.au/publications/health-professional/nps-radar
- NPS Direct, April 2015 includes:
-- 'Mirror, mirror': a blood test to reflect how best to quit smoking?
-- Antihypertensive medicine in pregnancy
-- Flu vaccination recommendations for 2015
http://www.nps.org.au/health-professionals/e-newsletters/nps-direct/2015/april
**TGA
- ASTRAZENECA suxamethonium chloride 100mg/2mL injection BP ampoule medicine shortage
http://www.tga.gov.au/alert/astrazeneca-suxamethonium-chloride-100mg2mlinjection-bp-ampoule-medicine-shortage
- Prostin F2 Alpha (dinoprost trometamol): discontinuation of supply of medicine
http://www.tga.gov.au/alert/prostin-f2-alpha-dinoprost-trometamoldiscontinuation-supply-medicine
- Zovirax Ophthalmic ointment; 2nd alternative product now available
http://www.tga.gov.au/alert/zovirax-ophthalmic-ointment
REPORTS AND PUBLICATIONS – INTERNATIONAL
**FDA
- FDA approves first generic Copaxone (glatiramer acetate injection) to treat
multiple sclerosis
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm443143.htm
- FDA approves Corlanor (ivabradine) to treat heart failure
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm442978.htm
**NICE
- Evidence summaries: Unlicensed or off-label medicines
-- Interstitial cystitis: oral pentosan polysulfate sodium [ESUOM43]
http://www.nice.org.uk/advice/esuom43
**RCOG
Reducing the Risk of
Venous Thromboembolism during Pregnancy and the Puerperium
https://www.rcog.org.uk/globalassets/documents/guidelines/gtg-37a.pdf
MEDICATION SAFETY
**AHRQ
New Interactive Training on Safe Opioid Use
http://health.gov/hcq/training.asp#pathways
**HQSNZ
Health Quality & Safety Commission | Safe use of opioids national collaborative
newsletter – Issue 1
http://www.hqsc.govt.nz/our-programmes/medication-safety/news-andevents/news/2107/
**ISMP
ENFit enteral devices are on their way...Important safety considerations for
hospitals
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=105
**UKMi
-What are the differences between US and UK drug names?
http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=796665
- What is the risk of interaction between opioids and monoamine oxidase inhibitors
(MAOIs)?
http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=796667
PAPERS OF INTEREST
**Am J Health-Syst Pharm
National trends in prescription drug expenditures and projections for 2015
http://www.ajhp.org/content/72/9/717.abstract
**Ann Intern Med
- Cost-Effectiveness and Population Impact of Statins for Primary Prevention in
Adults Aged 75 Years or Older in the United StatesStatins for Primary Prevention in
U.S. Adults Aged 75 Years or Older
http://annals.org/article.aspx?articleid=2275384
- Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012: A
Retrospective Cohort StudyMetformin Prescription for Insured Adults With
Prediabetes
http://annals.org/article.aspx?articleid=2275385
- Routine Iron Supplementation and Screening for Iron Deficiency Anemia in
Pregnancy: A Systematic Review for the U.S. Preventive Services Task ForceIron
Supplementation and Screening for Iron Deficiency Anemia in Pregnancy
http://annals.org/article.aspx?articleid=2212247
**BMJ
- Optimal duration of dual antiplatelet therapy after percutaneous coronary
intervention with drug eluting stents: meta-analysis of randomised controlled trials
http://www.bmj.com/content/350/bmj.h1618
- Selective serotonin reuptake inhibitors and venlafaxine in early pregnancy and risk
of birth defects: population based cohort study and sibling design
http://www.bmj.com/content/350/bmj.h1798
- Epidural steroid injections compared with gabapentin for lumbosacral radicular
pain: multicenter randomized double blind comparative efficacy study
http://www.bmj.com/content/350/bmj.h1748
- New drug for hepatitis C contributes to 13% rise in spending on prescription drugs
in US
http://www.bmj.com/content/350/bmj.h2055
**Cochrane
Lipid-lowering efficacy of atorvastatin
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008226.pub3/abstract
**JAMA Intern Med
Effects of Low Blood Pressure in Cognitively Impaired Elderly Patients Treated With
Antihypertensive Drugs
http://archinte.jamanetwork.com/article.aspx?articleid=2173093
**JAMIA
- Novel user interface design for medication reconciliation: an evaluation of
Twinlist
http://jamia.oxfordjournals.org/content/22/2/340.abstract
- Optimization of drug–drug interaction alert rules in a pediatric hospital's
electronic health record system using a visual analytics dashboard
http://jamia.oxfordjournals.org/content/22/2/361
- The long-term financial impact of electronic health record implementation
http://jamia.oxfordjournals.org/content/22/2/443
**Lancet
Adjunct prednisone therapy for patients with community-acquired pneumonia: a
multicentre, double-blind, randomised, placebo-controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)624478/abstract
**MJA
Polypharmacy among inpatients aged 70 years or older in Australia
https://www.mja.com.au/journal/2015/202/7/polypharmacy-among-inpatientsaged-70-years-or-olderaustralia?utm_source=MJA+news+alerts&utm_campaign=99686633a9MJA_news_vol_202_Issue_7_20_Apr_20154_16_2015&utm_medium=email&utm_ter
m=0_8c7e70a099-99686633a9-41328121
**Pediatrics
- Antidepressant Use During Pregnancy and Asthma in the Offspring
http://pediatrics.aappublications.org/content/135/4/e911.abstract
- Off-Label Use of Inhaled Nitric Oxide After Release of NIH Consensus Statement
http://pediatrics.aappublications.org/content/135/4/643.abstract
- Etiology of Childhood Bacteremia and Timely Antibiotics Administration in the
Emergency Department
http://pediatrics.aappublications.org/content/135/4/635.abstract
TAG Mail 15th April 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**AIHW
-National opioid pharmacotherapy statistics (NOPSAD)
http://www.aihw.gov.au/alcohol-and-other-drugs/nopsad/
-Australian Burden of Disease Study: fatal burden of disease in Aboriginal and
Torres Strait Islander people 2010
http://www.aihw.gov.au/publication-detail/?id=60129550618
**NPS-MedicineWise
-Heartburn and reflux
http://www.nps.org.au/conditions/digestive-system-problems/indigestion-refluxand-stomach-ulcers/heartburn-and-reflux
**TGA
- Dianeal peritoneal dialysis solution and various irrigation solutions - recall
https://www.tga.gov.au/alert/dianeal-peritoneal-dialysis-solution-and-variousirrigation-solutions
- TGA Reforms: A blueprint for TGA’s future: Progress report as at 31 December
2014
https://www.tga.gov.au/publication/tga-reforms-blueprint-tgas-future-progressreport-31-december-2014
REPORTS AND PUBLICATIONS – INTERNATIONAL
**CADTH
- What's on the 2015 Canadian Top 10 List of Game-Changing Health Technologies?
(includes andexanet alfa for bleeding episodes associated with the NOACs)
https://www.cadth.ca/whats-2015-canadian-top-10-list-game-changing-healthtechnologies
-Factor V Leiden and Prothrombin Mutation Testing in Patients With Unprovoked
Thromboembolism
https://www.cadth.ca/factor-v-leiden-and-prothrombin-mutation-testing-patientsunprovoked-thromboembolism
**Health Canada
- Summary Safety Review - PRADAXA (dabigatran) and MULTAQ (dronedarone) or
CORDARONE (amiodarone) - Drug-Drug Interaction
http://www.hc-sc.gc.ca/dhp-mps/medeff/reviewsexamens/dabigatran_dronedarone_amiodarone-eng.php
**NICE
- Savings and Productivity and Local Practice Collections: Stopping perioperative
antibiotics for post-tonsillectomy morbidity
http://www.nice.org.uk/savingsandproductivityandlocalpracticeresource?ci=http%3
A%2F%2Farms.evidence.nhs.uk%2Fresources%2FQIPP%2F1043205%3Fniceorg%3Dtrue
**Centre for Disease Control and Prevention
- National Action Plan for Combating Antibiotic-Resistant Bacteria
http://www.cdc.gov/drugresistance/solutions-initiative/index.html
**The Health Foundation
- Evaluation: what to consider. Commonly asked questions about how to approach
evaluation of quality improvement in health care
http://www.health.org.uk/publications/evaluation-what-to-consider/
- Using communications approaches to spread improvement
http://www.health.org.uk/publications/using-communications-approaches-tospread-improvement/
MEDICATION SAFETY
**AHRQ
Automated communication tools and computer-based medication reconciliation to
decrease hospital discharge medication errors.
http://www.psnet.ahrq.gov/resource.aspx?resourceID=28835
**EMA
-Pharmacovigilance Risk Assessment Committee recommends updating advice on
use of high-dose ibuprofen
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/04/news_detail_002306.jsp&mid=WC0b01ac058004d5c1
**FDA
- Abuse-Deterrent Opioids — Evaluation and Labeling Guidance
http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation
/Guidances/UCM334743.pdf
PAPERS OF INTEREST
** Ann Intern Med
-Screening for Type 2 Diabetes Mellitus: A Systematic Review for the U.S.
Preventive Services Task Force Screening for Type 2 Diabetes Mellitus
http://annals.org/article.aspx?articleID=2246121
**BMJ
- Disease activity guided dose reduction and withdrawal of adalimumab or
etanercept compared with usual care in rheumatoid arthritis
http://www.bmj.com/content/350/bmj.h1389-0
** BMJ Quality and Safety
- Preventing device-associated infections in US hospitals: national surveys from
2005 to 2013
http://qualitysafety.bmj.com/content/early/2015/04/10/bmjqs-2014003870.short?g=w_qs_ahead_tab
**Drug Safety
-Initiatives to Identify and Mitigate Medication Errors in England
https://dx.doi.org/10.1007/s40264-015-0270-3
**Eur J Hosp Pharm
- Pharmacist prescribing within a UK NHS hospital trust: nature and extent of
prescribing, and prevalence of errors
http://ejhp.bmj.com/content/22/2/79.full
- Integrated medicines management to medicines optimisation in Northern Ireland
(2000–2014): a review
http://ejhp.bmj.com/content/early/2015/04/13/ejhpharm-2014000512.short?g=w_ejhp_ahead_tab
**Health Affairs
-Efficacy And Safety Concerns Are Important Reasons Why The FDA Requires
Multiple Reviews Before Approval Of New Drugs
http://content.healthaffairs.org/content/34/4/681.abstract
** Heart
-Prevalence and antithrombotic management of atrial fibrillation in hospitalised
patients
http://heart.bmj.com/content/early/2015/04/14/heartjnl-2014-307059.full
** Heart, Lung and Circulation
- Indications for Omega-3 Long Chain Polyunsaturated Fatty Acid in the Prevention
and Treatment of Cardiovascular Disease
http://www.heartlungcirc.org/article/S1443-9506(15)00167-5/pdf
**Intern Med Journal
- Council of Australian Therapeutic Advisory Groups: supporting the Quality Use of
Medicines across the acute-care sector
http://onlinelibrary.wiley.com/doi/10.1111/imj.12709/abstract
- Understanding and improving the use of allopurinol in a teaching hospital
http://onlinelibrary.wiley.com/doi/10.1111/imj.12701/abstract
- Association between vitamin B12 deficiency and long-term use of acid-lowering
agents: a systematic review and meta-analysis
http://onlinelibrary.wiley.com/doi/10.1111/imj.12697/abstract
- Venous thromboembolism rates in patients undergoing major hip and knee joint
surgery at Waitemata District Health Board: a retrospective audit
http://onlinelibrary.wiley.com/doi/10.1111/imj.12702/abstract
** JAMA
-Site-Level Variation in and Practices Associated With Dabigatran Adherence
http://jama.jamanetwork.com/article.aspx?articleid=2247144
**JAMA Int Med
-Effects of Low Blood Pressure in Cognitively Impaired Elderly Patients Treated With
Antihypertensive Drugs
http://archinte.jamanetwork.com/article.aspx?articleid=2173093
-Prescription Opioid Duration of Action and the Risk of Unintentional Overdose
Among Patients Receiving Opioid Therapy
http://archinte.jamanetwork.com/article.aspx?articleid=2110997
**JAMIA
-Nature and management of duplicate medication alerts
http://jamia.oxfordjournals.org/content/early/2015/04/09/jamia.ocv021
**Journal of Hospital Medicine
-The July effect: an analysis of never events in the nationwide inpatient sample
http://psnet.ahrq.gov/resource.aspx?resourceID=28892
**Journal of Patient Safety
-Impact of inpatient harms on hospital finances and patient clinical outcomes.
http://psnet.ahrq.gov/resource.aspx?resourceID=28884
**The Lancet
- Crohn's disease management after intestinal resection: a randomised trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)619085/abstract
**The Lancet Neurology
-Effectiveness and cost-effectiveness of interferon beta and glatiramer acetate in
the UK Multiple Sclerosis Risk Sharing Scheme at 6 years: a clinical cohort study
with natural history comparator
http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)000186/abstract
** Pediatrics
-Safety and Efficacy of Pimecrolimus in Atopic Dermatitis: A 5-Year Randomized
Trial
http://pediatrics.aappublications.org/content/135/4/597.abstract
-Antipsychotic Medication Prescribing in Children Enrolled in Medicaid
http://pediatrics.aappublications.org/content/135/4/648.abstract
TAG Mail 1st April 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**NSW Health
- Privacy Manual for Health Information
http://www.health.nsw.gov.au/policies/manuals/Pages/privacy-manual-forhealth-information.aspx
- The Hospital Drug and Alcohol Consultation Liaison Model of Care
http://www.health.nsw.gov.au/mhdao/programs/da/Pages/Hosp-DA-consultmoc.aspx
**TGA
AusPARS added: Bevacizumab (Avastin), Tofacitinib (as citrate) (Xeljanz)
https://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars
REPORTS AND PUBLICATIONS – INTERNATIONAL
**FDA
FDA approves new treatment for diabetic retinopathy in patients with diabetic
macular edema
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm439838.htm
** The Joint Commission
Sentinel Event Alert 54: Safe use of health information technology
http://www.jointcommission.org/assets/1/18/SEA_54.pdf
**MHRA
Corticosteroids e-learning module launched - new module helps clinicians
understand how to identify, manage and avoid side effects when using
corticosteroids
https://www.gov.uk/drug-safety-update/corticosteroids-e-learning-modulelaunched
**NICE
- Evidence Update
-- Fertility
http://arms.evidence.nhs.uk/resources/hub/1043055/attachment
-- Psychosis and schizophrenia in children and young people
http://arms.evidence.nhs.uk/resources/hub/1043085/attachment
**SIGN
- Sign 142 Management of osteoporosis and the prevention of fragility fractures
http://www.sign.ac.uk/guidelines/fulltext/142/index.html
- SIGN 144 Glaucoma referral and safe discharge
http://www.sign.ac.uk/guidelines/fulltext/144/index.html
MEDICATION SAFETY
**EMA
New restrictions to minimise the risks of effects on heart rhythm with hydroxyzinecontaining medicines
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/03/news_detail_002296.jsp&mid=WC0b01ac058004d5c1
**FDA
- FDA Drug Safety Communication: FDA strengthens warnings and changes
prescribing instructions to decrease the risk of serious allergic reactions with
anemia drug Feraheme (ferumoxytol)
http://www.fda.gov/Drugs/DrugSafety/ucm440138.htm
- FDA Drug Safety Podcast: FDA warns of serious slowing of the heart rate when
antiarrhythmic drug amiodarone is used with hepatitis C treatments containing
sofosbuvir Harvoni or Sovaldi in combination with another Direct Acting Antiviral
drug
http://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm440475.htm
- FDA Drug Safety Podcast: FDA review of study sheds light on two deaths associated
with the injectable schizophrenia drug Zyprexa Relprevv (olanzapine pamoate)
http://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm440024.htm
**MHRA
Drug Safety Update: Dimethyl fumarate (Tecfidera): fatal PML in an MS patient with
severe, prolonged lymphopenia
https://www.gov.uk/drug-safety-update/dimethyl-fumarate-tecfidera-fatal-pml-ina-ms-patient-with-severe-prolonged-lymphopenia
**TGA
Medicines Safety Update, April 2015 includes: 2015 seasonal influenza vaccines;
Agomelatine (Valdoxan) - monitoring of liver function; Non-steroidal antiinflammatory drugs and diclofenac reviews
https://www.tga.gov.au/publication-issue/medicines-safety-update-volume-6number-2-april-2015
PAPERS OF INTEREST
**Am Health-Syst Pharm
- Comparison of warfarin time in the therapeutic range at a pharmacist-run
anticoagulation clinic and the RE-LY trial
http://www.ajhp.org/content/72/7/557.abstract
- Outpatient management of febrile neutropenia associated with cancer
chemotherapy: Risk stratification and treatment review
http://www.ajhp.org/content/72/8/619.abstract
- ASHP Guidelines on Preventing Medication Errors with Chemotherapy and
Biotherapy
http://www.ajhp.org/content/72/8/e6.full?hw-tma-check=true
**Ann Intern Med
- Routine Iron Supplementation and Screening for Iron Deficiency Anemia in
Pregnancy: A Systematic Review for the U.S. Preventive Services Task ForceIron
Supplementation and Screening for Iron Deficiency Anemia in Pregnancy
http://annals.org/article.aspx?articleid=2212247
- The Cost-Effectiveness of Sofosbuvir-Based Regimens for Treatment of Hepatitis C
Virus Genotype 2 or 3 InfectionSofosbuvir-Based Regimens for Treatment of HCV
Genotype 2 or 3 Infection
http://annals.org/article.aspx?articleid=2212248
**BMJ
Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic
review and meta-analysis of randomised placebo controlled trials
http://www.bmj.com/content/350/bmj.h1225
** BMJ Quality and Safety
How to study improvement interventions: a brief overview of possible study types
http://qualitysafety.bmj.com/content/early/2015/03/24/bmjqs-2014-003620.long
** Br J Anaesthiol
- Development and measurement of perioperative patient safety indicators
http://bja.oxfordjournals.org/content/early/2015/02/10/bja.aeu561
**Eur J Heart
The effect of statin therapy on heart failure events: a collaborative meta-analysis
of unpublished data from major randomized trials
http://eurheartj.oxfordjournals.org/content/early/2015/03/16/eurheartj.ehv072.a
bstract
**Eur J Hosp Pharm
The medication therapy management pyramid shifting medication review to an
integrated medication therapy management process
http://ejhp.bmj.com/content/early/2015/03/24/ejhpharm-2014000502.short?g=w_ejhp_ahead_tab
**JAMA
- Virologic Response Following Combined Ledipasvir and Sofosbuvir Administration
in Patients With HCV Genotype 1 and HIV Co-infection
http://jama.jamanetwork.com/article.aspx?articleid=2173266
- Ombitasvir, Paritaprevir Co-dosed With Ritonavir, Dasabuvir, and Ribavirin for
Hepatitis C in Patients Co-infected With HIV-1: A Randomized Trial
http://jama.jamanetwork.com/article.aspx?articleid=2173265
**JAMA Intern Med
Reducing Inappropriate Polypharmacy: The Process of Deprescribing
http://archinte.jamanetwork.com/article.aspx?articleid=2204035
**JAMIA
- Recommendations to Improve the Usability of Drug-Drug Interaction Clinical
Decision Support Alerts
http://jamia.oxfordjournals.org/content/early/2015/03/30/jamia.ocv011
**Lancet
140 mmol/L of sodium versus 77 mmol/L of sodium in maintenance intravenous
fluid therapy for children in hospital (PIMS): a randomised controlled double-blind
trial
http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(14)61459-8.pdf
**NEJM
Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema
http://www.nejm.org/doi/full/10.1056/NEJMoa1414264
TAG Mail 25th March 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**ACSQHC
A better way to care: Dementia and delirium posters
http://www.safetyandquality.gov.au/publications/a-better-way-to-care-dementiaand-delirium-posters/
**AIHW
- Cardiovascular disease, diabetes and chronic kidney disease - Australian facts: risk
factors
http://www.aihw.gov.au/publication-detail/?id=60129550538
- COPD snapshot
http://www.aihw.gov.au/copd/
- Admitted patient care 2013-14: Australian hospital statistics
http://www.aihw.gov.au/publication-detail/?id=60129550483
- Mental health services in Australia
http://mhsa.aihw.gov.au/home/
**HETI
Biannual Report, January 2015
http://www.heti.nsw.gov.au/about/heti-reports/
**NHMRC
A statement summarising the evidence on the safety, quality and efficacy of ecigarettes
http://www.nhmrc.gov.au/media/releases/2015/nhmrc-ceo-releases-statement-ecigarettes
**NPS-MedicineWise
Vaccination recommendations for the 2015 influenza season
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/2015-fluvax-recommendations
**NSW Health
Infants and Children: Acute Management of Community Acquired Pneumonia
Clinical Practice Guideline
http://www0.health.nsw.gov.au/policies/gl/2015/GL2015_005.html
**TGA
- AusPARS added: Influenza Virus Haemagglutinin H1N1, H3N2, B Victoria lineage, B
Yamagata lineage (FluQuadri, FluQuadri Junior), Peginterferon beta 1a (rch)
(Plegridy)
https://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars
- Reasons for the medicines scheduling delegates final decisions, March 2015
https://www.tga.gov.au/scheduling-decision-final/reasons-medicines-schedulingdelegates-final-decisions-march-2015-medicines
REPORTS AND PUBLICATIONS – INTERNATIONAL
**HQSCNZ
- Attributes of a health literate organisation
http://www.hqsc.govt.nz/our-programmes/consumer-engagement/publicationsand-resources/publication/2048/
- Enliven organisational health literacy self-assessment resource
http://www.hqsc.govt.nz/our-programmes/consumer-engagement/publicationsand-resources/publication/2047/
- Three steps to better health literacy – a guide for health care professionals
http://www.hqsc.govt.nz/publications-and-resources/publication/2046/
**NICE
- Evidence summaries: medicines and prescribing briefings
-- Clostridium difficile infection: risk with broad-spectrum antibiotics [ESMPB1]
http://www.nice.org.uk/advice/esmpb1
- Evidence summary: new medicine
-- Glaucoma: brinzolamide/brimonidine combination eye drops [ESNM56]
http://www.nice.org.uk/advice/esnm56
-- Asthma: tiotropium (Spiriva Respimat) [ESNM55]
http://www.nice.org.uk/advice/esnm55
- Evidence summary: unlicensed or off-label medicine
-- Digital ulcers: sildenafil [ESUOM42]
http://www.nice.org.uk/advice/esuom42
- Quality Standards
-- Alcohol: preventing harmful alcohol use in the community [QS83]
http://www.nice.org.uk/guidance/qs83
-- Falls in older people: assessment after a fall and preventing further falls [QS86]
http://www.nice.org.uk/guidance/qs86
-- Managing medicines in care homes [QS85]
http://www.nice.org.uk/guidance/qs85
- Technology appraisals
-- Rivaroxaban for preventing adverse outcomes after acute management of acute
coronary syndrome [TA335]
http://www.nice.org.uk/guidance/ta335
-- Rifaximin for preventing episodes of overt hepatic encephalopathy [TA337]
http://www.nice.org.uk/guidance/ta337
-- Pomalidomide for relapsed and refractory multiple myeloma previously treated
with lenalidomide and bortezomib [TA338]
http://www.nice.org.uk/guidance/ta338
-- Empagliflozin in combination therapy for treating type 2 diabetes [TA336]
http://www.nice.org.uk/guidance/ta336
**The Joint Commission
Accelerating the Adoption of a Safety Culture
http://www.jointcommission.org/assets/1/18/Healthcare_Executive_McKee_03201
5.pdf
**The King’s Fund
Acute hospitals and integrated care: From hospitals to health systems
http://www.kingsfund.org.uk/publications/acute-hospitals-and-integrated-care
MEDICATION SAFETY
**FDA
- FDA Drug Safety Communication: FDA warns of serious slowing of the heart rate
when antiarrhythmic drug amiodarone is used with hepatitis C treatments
containing sofosbuvir (Harvoni or Sovaldi) in combination with another Direct Acting
Antiviral drug
http://www.fda.gov/Drugs/DrugSafety/ucm439484.htm
- FDA Drug Safety Communication: FDA review of study sheds light on two deaths
associated with the injectable schizophrenia drug Zyprexa Relprevv (olanzapine
pamoate)
http://www.fda.gov/Drugs/DrugSafety/ucm439147.htm
PAPERS OF INTEREST
**Am J Health-Syst Pharm
- Comparative efficacy and safety of insulin analogs in hospitalized adults
http://www.ajhp.org/content/72/7/525
- Development of recommendations for dosing of commonly prescribed medications
in critically ill obese children
http://www.ajhp.org/content/72/7/542
- ASHP Guidelines on the Pharmacist’s Role in Providing Drug Information
http://www.ajhp.org/content/72/7/573
**Cochrane Library
Corticosteroid therapy for nephrotic syndrome in children
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD001533.pub5
**JAMA IntMed
- Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective
Cohort Study
http://archinte.jamanetwork.com/article.aspx?articleid=2091745
- Out-of-Hospital Mortality Among Patients Receiving Methadone for Noncancer Pain
http://archinte.jamanetwork.com/article.aspx?articleid=2091400
**Lancet
Brentuximab vedotin as consolidation therapy after autologous stem-cell
transplantation in patients with Hodgkin's lymphoma at risk of relapse or
progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3
trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)601659/abstract
**MJA
- Evolving views and practices of antiretroviral treatment prescribers in Australia
https://www.mja.com.au/journal/2015/202/5/evolving-views-and-practicesantiretroviral-treatment-prescribers-australia
- Facing the challenge of multidrug-resistant gram-negative bacilli in Australia
https://www.mja.com.au/journal/2015/202/5/facing-challenge-multidrugresistant-gram-negative-bacilli-australia
TAG Mail 18th March 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**AIHW
- Asthma snapshot, January 2015
http://www.aihw.gov.au/asthma/
- Arthritis, osteoporosis and other musculoskeletal conditions
http://www.aihw.gov.au/arthritis-and-musculoskeletal-conditions/
**CEC
- Continuity of Medication Management Toolkit
http://www.cec.health.nsw.gov.au/programs/continuity-of-medicationmanagement#toolkit
- MSQ Connect, March 2015 includes: Tall Man Lettering | Medication Safety Self
Assessment
http://www.cec.health.nsw.gov.au/__documents/programs/insafehands/2015/msq
_-connect_-newsletter_-march_-2015.pdf
**NHMRC
NHMRC releases statement and advice on homeopathy
http://www.nhmrc.gov.au/media/releases/2015/nhmrc-releases-statement-andadvice-homeopathy
**NPS MedicineWise
NPS Direct – March 2015 includes: Diabetes drugs for weight management? | Highrisk younger people missing out on flu vaccine | Accidental fentanyl exposure can
be fatal | Warfarin safety update | Fast five: Improving asthma control
http://www.nps.org.au/health-professionals/e-newsletters/nps-direct/2015/march
**NSW Health
- Safety Alert: Suxamethonium Chloride Injection BP 100mg / 2mL Disruption to
Supply
http://www.health.nsw.gov.au/sabs/Documents/2015-sn-001.pdf
- Policy Directive: Tuberculosis Management of People Knowingly Placing Others at
Risk of Infection
http://www0.health.nsw.gov.au/policies/pd/2015/PD2015_012.html
**TGA
AusPARS added: Empagliflozin (Jardiance)
https://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars
REPORTS AND PUBLICATIONS – INTERNATIONAL
**AHRQ
Public Reporting of Cost Measures in Health
http://www.effectivehealthcare.ahrq.gov/search-for-guides-reviews-andreports/?pageaction=displayproduct&productID=2053
**FDA
FDA approves Cholbam to treat rare bile acid synthesis disorders (cholic acid)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm438572.htm
**HQSCNZ
Three-fold opioid variation a cue to look at prescribing, says Commission
http://www.hqsc.govt.nz/news-and-events/media/2042/
**NICE
- Evidence summary: unlicensed or off-label medicine
-- Management of aggression, agitation and behavioural disturbances in dementia:
carbamazepine [ESUOM40]
http://www.nice.org.uk/advice/esuom40
-- Management of aggression, agitation and behavioural disturbances in dementia:
valproate preparations [ESUOM41]
http://www.nice.org.uk/advice/esuom41
- Eyes on Evidence
-- Allopurinol for chronic gout
http://nice.us8.listmanage1.com/track/click?u=7864f766b10b8edd18f19aa56&id=1a8a180079&e=9c2fd
5fb40
- Medicines Evidence Commentary
-- MHRA drug safety advice: drugs and driving
http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=795618
- Public health guidelines
-- Maintaining a healthy weight and preventing excess weight gain among adults and
children [NG7]
http://www.nice.org.uk/guidance/ng7
**WHO
Guidelines for the prevention, care and treatment of persons with chronic hepatitis
B infection
http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/
MEDICATION SAFETY
**EMA
- PRAC recommends restrictions on the use of codeine for cough and cold in
children
- PRAC recommends further measures to minimise known risk of osteonecrosis of
the jaw associated with bisphosphonate medicine
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/03/news_detail_002285.jsp&mid=WC0b01ac058004d5c1
**FDA
FDA warns health care professionals not to use Treanda Injection (solution bendamustine hydrochloride) with closed system transfer devices, adapters, and
syringes containing polycarbonate or acrylonitrile-butadiene-styrene
http://www.fda.gov/Drugs/DrugSafety/ucm437469.htm
**ISMP
Delayed administration and contraindicated drugs place hospitalized Parkinson’s
disease patients at risk
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=103
**TGA
Medicines supplied without child-resistant caps - multiple brands recalled
https://www.tga.gov.au/alert/medicines-supplied-without-child-resistant-capsmultiple-brands
PAPERS OF INTEREST
**Ann Intern Med
- Cost-Effectiveness and Budget Impact of Hepatitis C Virus Treatment With
Sofosbuvir and Ledipasvir in the United StatesCost-Effectiveness of HCV Treatment
With Sofosbuvir and Ledipasvir
http://annals.org/article.aspx?articleid=2197176
- Cost-Effectiveness of Novel Regimens for the Treatment of Hepatitis C VirusCostEffectiveness of New Regimens for Hepatitis C Virus
http://annals.org/article.aspx?articleid=2197177
**BMJ
- Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and
inflammatory bowel disease: systematic literature review and meta-analysis of
randomised controlled trials
http://www.bmj.com/content/350/bmj.h1269
- Risk of neuropsychiatric adverse events associated with varenicline: systematic
review and meta-analysis
http://www.bmj.com/content/350/bmj.h1109
- Statins and congenital malformations: cohort study
http://www.bmj.com/content/350/bmj.h1035
- Drug-disease and drug-drug interactions: systematic examination of
recommendations in 12 UK national clinical guidelines
http://www.bmj.com/content/350/bmj.h949
- Tumour necrosis factor inhibitors versus combination intensive therapy with
conventional disease modifying anti-rheumatic drugs in established rheumatoid
arthritis: TACIT non-inferiority randomised controlled trial
http://www.bmj.com/content/350/bmj.h1046
**Cochrane
Hormone therapy for preventing cardiovascular disease in post-menopausal women
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD002229.pub4
**JAMA
Antiplatelet Therapy Duration Following Bare Metal or Drug-Eluting Coronary Stents:
The Dual Antiplatelet Therapy Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2203799
**Lancet
Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with
or at risk for type 2 diabetes: a meta-analysis of randomised controlled trials
http://www.thelancet.com/journals/landia/article/PIIS2213-8587(15)000443/abstract
**MJA
Effectiveness of a care bundle to reduce central line-associated bloodstream
infections
https://www.mja.com.au/journal/2015/202/5/effectiveness-care-bundle-reducecentral-line-associated-bloodstream-infections
**Pediatrics
- Medication-Related Emergency Department Visits in Pediatrics: a Prospective
Observational Study
http://pediatrics.aappublications.org/content/135/3/435.abstract
- Azithromycin in Early Infancy and Pyloric Stenosis
http://pediatrics.aappublications.org/content/135/3/483.abstract
TAG Mail 11th March 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**NPS-MedicineWise
Diabetes drugs for weight management?
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/diabetes-drugs-for-weight-management
**TGA
- TGA key performance indicators: July to December 2014
https://www.tga.gov.au/publication/tga-key-performance-indicators-julydecember-2014
- Zovirax Ophthalmic ointment - Update 2 - alternative product now available
https://www.tga.gov.au/alert/zovirax-ophthalmic-ointment
- AusPARS added: Brimonidine (as tartrate) (Mirvaso), Efraloctocog alfa (rhu)
(Eloctate), Ezetimibe / Rosuvastatin (as calcium) (Ezalo, Rosuzet) and Sucroferric
oxyhydroxide (Velphoro)
https://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars
- Updates to the list of designated orphan drugs: Amikacin Sulfate
https://www.tga.gov.au/updates-list-designated-orphan-drugs
REPORTS AND PUBLICATIONS – INTERNATIONAL
**CADTH
Rapid response: Switching from Innovator to Biosimilar (Subsequent Entry)
Infliximab: A Review of the Clinical Effectiveness, Cost-Effectiveness, and
Guidelines
http://www.cadth.ca/media/pdf/htis/mar2015/RC0635%20Infliximab%20Switching%20Final.pdf
**FDA
- FDA approves first therapy for high-risk neuroblastoma, Unituxin (dinutuximab)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm437460.htm
- FDA approves first biosimilar product Zarxio (filgrastim-sndz)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm436648.htm
- FDA approves new antifungal drug Cresemba, (isavuconazonium sulfate)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm437106.htm
**NICE
Guideline: Medicines optimisation: the safe and effective use of medicines to
enable the best possible outcomes
http://www.nice.org.uk/guidance/ng5
**The Joint Commission
Quick Safety - Issue Ten February 2015: Preventing copy-and-paste errors in EHRs
http://www.jointcommission.org/issues/article.aspx?Article=bj%2b%2f2w37MuZrou
WveszI1weWZ7ufX%2fP4tLrLI85oCi0%3d&j=2434516&e=nswtag@stvincents.com.au&l
=9552_HTML&u=43350978&mid=1064717&jb=0
MEDICATION SAFETY
**FDA
- FDA Drug Safety Communication: FDA updates label for stop smoking drug Chantix
(varenicline) to include potential alcohol interaction, rare risk of seizures, and
studies of side effects on mood, behavior, or thinking
http://www.fda.gov/Drugs/DrugSafety/ucm436494.htm
- FDA Drug Safety Podcast: FDA cautions about using testosterone products for low
testosterone due to aging; requires labeling change to inform of possible increased
risk of heart attack and stroke with use
http://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm436688.htm
**Health Canada
Health Product InfoWatch, February 2015 includes Summary Safety Reviews of
Aricept (donepezil), Atypical Antipsychotics, Domperidone, Metoclopramide, Prolia
(denosumab), Vascular Endothelial Growth Factor Receptor Inhibitors
http://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2015-02-eng.php#a2
PAPERS OF INTEREST
**Clin Ther
Impact of Switching From High-Efficacy Lipid-Lowering Therapies to Generic
Simvastatin on LDL-C Levels and LDL-C Goal Attainment Among High-Risk Primary
and Secondary Prevention Populations in the United Kingdom
http://www.ncbi.nlm.nih.gov/pubmed/25626487
**Cochrane
Interventions for reducing medication errors in children in hospital
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD006208.pub3
**Diabetes Care
Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered
approach: update to a position statement of the American Diabetes Association and
the European Association for the Study of Diabetes
http://care.diabetesjournals.org/content/38/1/140.long
**Intern Med J
- Thromboprophylaxis in patients undergoing total hip and knee arthroplasty: a
review of current practices in an Australian teaching hospital
http://onlinelibrary.wiley.com/doi/10.1111/imj.12675/abstract
- Assessment of aminoglycoside dosing and estimated glomerular filtration rate in
determining gentamicin and tobramycin area under the curve and clearance
http://onlinelibrary.wiley.com/doi/10.1111/imj.12684/abstract
**JAMA Intern Med
Continuous Proton Pump Inhibitor Therapy and the Associated Risk of Recurrent
Clostridium difficile Infection
http://archinte.jamanetwork.com/article.aspx?articleid=2173095
**Lancet
- Genetics and the clinical response to warfarin and edoxaban: findings from the
randomised, double-blind ENGAGE AF-TIMI 48 trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)619942/abstract
- Association between edoxaban dose, concentration, anti-Factor Xa activity, and
outcomes: an analysis of data from the randomised, double-blind ENGAGE AF-TIMI
48 trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)619437/abstract
- Effect of roflumilast on exacerbations in patients with severe chronic obstructive
pulmonary disease uncontrolled by combination therapy (REACT): a multicentre
randomised controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)624107/abstract
TAG Mail 4th March 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**TGA
AusPARS added: Bendamustine hydrochloride (Ribomustin), Febuxostat (FBX)
(Adenuric) and Tocilizumab (rch) (Actemra)
https://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars
REPORTS AND PUBLICATIONS – INTERNATIONAL
**CADTH
- Rapid responses:
- Dehydroepiandrosterone for the Treatment of Menopausal or Andropausal
Symptoms: Clinical Effectiveness and Safety
http://www.cadth.ca/media/pdf/htis/feb2015/RB0795%20DHEA%20for%20Menopause%20Final.pdf
- Dehydroepiandrosterone for the Treatment of Infertility: Clinical Effectiveness
and Safety
http://www.cadth.ca/media/pdf/htis/feb2015/RB0796%20DHEA%20for%20Infertility%20Final.pdf
- Enemas for the Treatment of Constipation in the Emergency Department: Clinical
Effectiveness and Guidelines
http://www.cadth.ca/media/pdf/htis/feb2015/RB0791%20Enemas%20for%20Fecal%20Impaction%20Final.pdf
- Long-term Use of Cyclobenzaprine for Pain: A Review of the Clinical Effectiveness
http://www.cadth.ca/media/pdf/htis/feb2015/RC0634%20Cyclobenzaprine%20Final.pdf
- The Timing of Prophylactic Antibiotics for Surgery: Clinical Evidence
http://www.cadth.ca/media/pdf/htis/feb2015/RA0735%20Preop%20Antibiotics%20Final.pdf
-- Topical Nitroglycerin for Peripheral Circulation and Wound Healing in the Elderly:
Clinical Effectiveness and Guidelines
http://www.cadth.ca/media/pdf/htis/feb2015/RB0792%20Nitroglycerin%20for%20Circulation%20Final.pdf
**EMA
- Jinarc (tolvaptan) recommended for approval in rare kidney disease
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/02/news_detail_002280.jsp&mid=WC0b01ac058004d5c1
- Zykadia (ceritinib) recommended for approval in advanced non small cell lung
cancer
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/02/news_detail_002279.jsp&mid=WC0b01ac058004d5c1
**FDA
FDA approves new antibacterial drug Avycaz (ceftazidime-avibactam)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm435629.htm
**NICE
- Clinical guidelines: Depression in children and young people: Identification and
management in primary, community and secondary care [CG28]
http://www.nice.org.uk/guidance/cg28
- Quality Standard: Inflammatory bowel disease [QS81]
http://www.nice.org.uk/guidance/qs81
- Evidence summaries New medicines: Asthma: tiotropium (Spiriva Respimat)
[ESNM55]
http://www.nice.org.uk/advice/esnm55
MEDICATION SAFETY
**EMA
Ambroxol and bromhexine expectorants: safety information to be updated (Risk of
allergy and skin reactions to be included)
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/02/news_detail_002276.jsp&mid=WC0b01ac058004d5c1
**FDA
- FDA Drug Safety Communication: FDA cautions about using testosterone products
for low testosterone due to aging; requires labelling change to inform of possible
increased risk of heart attack and stroke with use
http://www.fda.gov/Drugs/DrugSafety/ucm436259.htm
- FDA Drug Safety Podcast: FDA requires label warnings to prohibit sharing of multidose diabetes pen devices among patients
http://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm436028.htm
**NHS-UKMi
In-use product safety assessment report: Remsima® and inflectra® (infliximab
biosimilars)
http://www.ukmi.nhs.uk/filestore/ukmiaps/ProductsafetyassessmentforinfliximabF
eb-2015.pdf
**ISMP
EPINEPHrine for anaphylaxis: Autoinjector or 1 mg vial or ampul?
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=102
PAPERS OF INTEREST
**Cochrane
- Oxycodone for cancer-related pain
http://www.cochrane.org/CD003870/SYMPT_oxycodone-for-cancer-related-pain
- Antiplatelet agents for preventing failure of peripheral arterial grafts
http://www.cochrane.org/CD000535/PVD_antiplatelet-agents-for-preventingfailure-of-peripheral-arterial-grafts
**Eur J Hosp Pharm
- Pharmacist intervention in a psychiatric setting
http://ejhp.bmj.com/content/early/2015/03/02/ejhpharm-2014000564.short?g=w_ejhp_ahead_tab
- Clinical impact of the hospital pharmacy drug information service: how does
information on drug–drug interaction enquiries translate into clinical decisions?
http://ejhp.bmj.com/content/22/2/83.abstract
**International Journal of Medical Informatics
Clinical safety of England's national programme for IT: A retrospective analysis of
all reported safety events 2005 to 2011
http://www.sciencedirect.com/science/article/pii/S1386505614002482
**International Journal of Pharmacy Practice
Reducing unacceptable missed doses: pharmacy assistant-supported medicine
administration
http://onlinelibrary.wiley.com/doi/10.1111/ijpp.12172/abstract;jsessionid=ABBB3
F6BCCE883F94D1E1D8AEE3DEC29.f02t02?systemMessage=Wiley+Online+Library+will+
be+disrupted+on+7th+March+from+10%3A00-13%3A00+GMT+%2805%3A0008%3A00+EST%29+for+essential+maintenance.++Apologies+for+the+inconvenience
**Intern Med J
Assessment of aminoglycoside dosing and estimated glomerular filtration rate in
determining gentamicin and tobramycin area under the curve and clearance (pages
319–329)
http://onlinelibrary.wiley.com/enhanced/doi/10.1111/imj.12684/
**JAMA Intern Med
Potential Overtreatment of Diabetes Mellitus in Older Adults With Tight Glycemic
Control
http://archinte.jamanetwork.com/article.aspx?articleid=2089233
**Lancet
- Co-trimoxazole prophylaxis in adults, including pregnant women, with HIV: a
systematic review and meta-analysis
http://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(15)000053/abstract
- Extended duration dual antiplatelet therapy and mortality: a systematic review
and meta-analysis
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)620523/abstract
**Pediatrics
Medication-Related Emergency Department Visits in Pediatrics: a Prospective
Observational Study
http://pediatrics.aappublications.org/content/135/3/435.abstract
TAG Mail 25th February 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**NSW Health
- Alert notice: Any Glutathione Batch No: SY51.898-20141209 originating from
Zhejiang Senyo Biotech Co Ltd, China, or from Cheung Wing Pharmchem, China
must be quarantined and NSW Ministry of Health, Pharmaceutical Services must be
informed about any recipients of medicines compounded from it
- Policy Directive: Pharmaceuticals - Preparation in NSW Public Health Facility
Pharmacy Services
http://www0.health.nsw.gov.au/policies/pd/2015/PD2015_007.html
**NPS-MedicineWise
- High-risk younger people missing out on flu vaccine
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/young-missing-flu-vaccine
- NPS Direct Feb 2015 includes: Obesity: simple solutions for a complex problem |
LDL cholesterol: a surrogate supported | Biosimilars: what's in a name? | Fast five:
Type 2 diabetes – upskill with these resources
http://www.nps.org.au/health-professionals/e-newsletters/npsdirect/2015/february
REPORTS AND PUBLICATIONS – INTERNATIONAL
**FDA
FDA approves Farydak (panobinostat) for treatment of multiple myeloma
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm435296.htm
**Health Canada
Risperidone - Restriction of the Dementia Indication
http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2015/43797a-eng.php
**NICE
- Medicines Evidence Commentary includes: Risk of fall injuries in older people with
commonly prescribed medicines
https://www.nice.org.uk/Media/Default/newsletter/Eyes%20on%20Evidence%20Feb
ruary%202015.pdf
- Clinical guidlines
-- Bladder cancer: diagnosis and management of bladder cancer [NG2]
http://www.nice.org.uk/guidance/ng2
-- Diabetes in pregnancy: management of diabetes and its complications from
preconception to the postnatal period [NG3]
http://www.nice.org.uk/guidance/ng3
- Technology appraisals
-- Infliximab, adalimumab and golimumab for treating moderately to severely
active ulcerative colitis after the failure of conventional therapy (including a
review of TA140 and TA262) [TA329]
http://www.nice.org.uk/guidance/ta329
-- Sofosbuvir for treating chronic hepatitis C [TA330]
http://www.nice.org.uk/guidance/ta330
-- Simeprevir in combination with peginterferon alfa and ribavirin for treating
genotypes 1 and 4 chronic hepatitis C [TA331]
http://www.nice.org.uk/guidance/ta331
-- Sipuleucel-T for treating asymptomatic or minimally symptomatic metastatic
hormone-relapsed prostate cancer [TA332]
http://www.nice.org.uk/guidance/ta332
-- Axitinib for treating advanced renal cell carcinoma after failure of prior systemic
treatment [TA333]
http://www.nice.org.uk/guidance/ta333
**Public Health England-Dept of Health
Antibiotic prescribing and behaviour change in healthcare settings
https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/4
05031/Behaviour_Change_for_Antibiotic_Prescribing_-_FINAL.pdf
MEDICATION SAFETY
**HQSCNZ
Medication Safety Watch Issue 13 includes: Error prevention strategies | One steps
for medication safety | Azithromycin/Azathioprine (confusion)
http://www.hqsc.govt.nz/our-programmes/medication-safety/publications-andresources/publication/2014/
**ISMP
Free webinar 'Improving Medication Safety in the Perioperative Setting' for a target
audience of pharmacists, pharmacy technician and nurses
http://s3.proce.com/res/flash/Periop/story.html
PAPERS OF INTEREST
**BMJ
- Antidepressant use and risk of suicide and attempted suicide or self harm in
people aged 20 to 64: cohort study using a primary care database
http://www.bmj.com/content/350/bmj.h517
- Patient controlled analgesia with remifentanil versus epidural analgesia in labour:
randomised multicentre equivalence trial
http://www.bmj.com/content/350/bmj.h846
**Eur J Hosp POharm
Medicines wastage evaluation and prescription management in homecare medicines
in Nottingham University Hospitals NHS Trust
http://ejhp.bmj.com/content/early/2015/02/05/ejhpharm-2014000594.short?g=w_ejhp_ahead_tab
**Intern Med J
- Does the availability of therapeutic drug monitoring, computerised dose
recommendation and prescribing decision support services promote compliance
with national gentamicin prescribing guidelines?
http://onlinelibrary.wiley.com/enhanced/doi/10.1111/imj.12627/
- Transition from hospital to primary care: an audit of discharge summary –
medication changes and follow-up expectations
http://onlinelibrary.wiley.com/enhanced/doi/10.1111/imj.12581/
**JAMA
- Association of NSAID Use With Risk of Bleeding and Cardiovascular Events in
Patients Receiving Antithrombotic Therapy After Myocardial Infarction
http://jama.jamanetwork.com/article.aspx?articleid=2130316
- Anticoagulant Reversal, Blood Pressure Levels, and Anticoagulant Resumption in
Patients With Anticoagulation-Related Intracerebral Hemorrhage
http://jama.jamanetwork.com/article.aspx?articleid=2130317
- Ombitasvir, Paritaprevir Co-dosed With Ritonavir, Dasabuvir, and Ribavirin for
Hepatitis C in Patients Co-infected With HIV-1: A Randomized Trial
http://jama.jamanetwork.com/article.aspx?articleid=2173265
**JAMA Intern Med
- Long-term Nicotine Replacement Therapy: A Randomized Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=2167116
- Hospital Ward Antibiotic Prescribing and the Risks of Clostridium difficile Infection
http://archinte.jamanetwork.com/article.aspx?articleid=2130725
**JAMIA
Visualizing collaborative electronic health record usage for hospitalized patients
with heart failure
http://jamia.oxfordjournals.org/content/early/2015/02/20/jamia.ocu017
** Mayo Clin Proc
The Safety of Intravenous Iron Preparations: Systematic Review and Meta-analysis
http://www.ncbi.nlm.nih.gov/pubmed/25572192
**MJA
Knowing when to stop antibiotic therapy
https://www.mja.com.au/journal/2015/202/3/knowing-when-stop-antibiotictherapy
**NEJM
Pertuzumab, Trastuzumab, and Docetaxel in HER2-Positive Metastatic Breast
Cancer
http://www.nejm.org/doi/full/10.1056/NEJMoa1413513
TAG Mail 18th February 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**NPS-MedicineWise
Obesity: finding simple solutions to a global problem
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/obesity-solutions
**NSW Health
NSW Healthy Eating Active Living Strategy Status Report Year1 2014
http://www.health.nsw.gov.au/heal/Pages/Strategy-Status-Report-Yr1-2014.aspx
**TGA
- Warfarin review
https://www.tga.gov.au/alert/warfarin-review
- with ACSOM advice
https://www.tga.gov.au/committee-meeting-info/acsom-meeting-statementmeeting-22-9-may-2014
- Orphan drug added: Para-aminosalicylic acid (PASER)
https://www.tga.gov.au/updates-list-designated-orphan-drugs
REPORTS AND PUBLICATIONS – INTERNATIONAL
**CADTH
Rapid response: Multidisciplinary Chronic Non-Cancer Pain Programs for Adults:
Guidelines for Referral, Treatment Management and Program Duration
http://www.cadth.ca/media/pdf/htis/feb2015/RB0786%20Chronic%20Pain%20Programs%20Final.pdf
**FDA
- FDA approves Lenvima (lenvatinib) for a type of thyroid cancer
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm434288.htm
- FDA issues new draft documents related to compounding of human drugs
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm434270.htm
**NHS
Seven steps to managing polypharmacy
http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=794907
**NICE
Quality standard: Psychosis and schizophrenia in adults [QS80]
http://www.nice.org.uk/guidance/qs80
**HQSCNZ
Poster: Communicating so people will understand
http://www.open.hqsc.govt.nz/medication/publications-andresources/publication/1984/
MEDICATION SAFETY
**EMA
PRAC recommends new measures to minimise known heart risks of hydroxyzinecontaining medicines
http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/H
ydroxyzine_31/Recommendation_provided_by_Pharmacovigilance_Risk_Assessment
_Committee/WC500182461.pdf
**GOV.UK-MHRA
- Drugs and driving: blood concentration limits set for certain drugs
https://www.gov.uk/drug-safety-update/drugs-and-driving-blood-concentrationlimits-set-for-certain-drugs
- Letters sent to healthcare professionals since November 2014: vismodegib
(Erivedge ▼), chlorhexidine solutions, carbocisteine oral liquid (Mucodyne
Paediatric 125mg/5ml), regadenoson (Rapiscan), a parenteral nutrition emulsion
(Triomel), and telavancin (Vibativ▼)
https://www.gov.uk/drug-safety-update/letters-sent-to-healthcare-professionalssince-november-2014
**HDIS
Fact sheet: Can 5–HT3 antagonists (e.g., ondansetron etc.) really contribute to
serotonin toxicity?
http://www.ciap.health.nsw.gov.au/nswtag/members/other-topics-interest.html
**ISMP
Getting closer to the bull’s eye: 2014-2015 Targeted Medication Safety Best
Practices (Follow-up survey results)
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=101
PAPERS OF INTEREST
**Annals of Emergency Medicine
Intercepting Wrong-Patient Orders in a Computerized Provider Order Entry System
http://www.annemergmed.com/article/S0196-0644(14)01558-3/abstract
**JAMA
- Effect of Corticosteroids on Treatment Failure Among Hospitalized Patients With
Severe Community-Acquired Pneumonia and High Inflammatory Response: A
Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2110967
- Association Between the Use of Fondaparinux vs Low-Molecular-Weight Heparin
and Clinical Outcomes in Patients With Non–ST-Segment Elevation Myocardial
Infarction
http://jama.jamanetwork.com/article.aspx?articleid=2110970
**JAMA Intern Med
- Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure,
and Mortality in Older Nursing Home Residents: The PARTAGE Study
http://archinte.jamanetwork.com/article.aspx?articleid=2110995
- Prescription Opioid Duration of Action and the Risk of Unintentional Overdose
Among Patients Receiving Opioid Therapy
http://archinte.jamanetwork.com/article.aspx?articleid=2110997
**JAMIA
- Cost-effectiveness analysis of a hospital electronic medication management
system
http://jamia.oxfordjournals.org/content/early/2015/02/09/jamia.ocu014
- Novel user interface design for medication reconciliation: an evaluation of
Twinlist
http://jamia.oxfordjournals.org/content/early/2015/02/07/jamia.ocu021
**Lancet
- Prescribing safety: ensuring that new graduates are prepared
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)623394/abstract
- Efficacy of nitric oxide, with or without continuing antihypertensive treatment,
for management of high blood pressure in acute stroke (ENOS): a partial-factorial
randomised controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)611211/abstract
**MJA
Antimicrobial stewardship resources and activities for children in tertiary hospitals
in Australasia: a comprehensive survey
https://www.mja.com.au/journal/2015/202/3/antimicrobial-stewardshipresources-and-activities-children-tertiaryhospitals?utm_source=MJA+news+alerts&utm_campaign=43a79e7e6dMJA_news_vol_202_Issue_3_16_Feb_20152_12_2015&utm_medium=email&utm_ter
m=0_8c7e70a099-43a79e7e6d-41328121
TAG Mail 11th February 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**NPS MedicineWise
Accidental fentanyl exposure in children can be fatal
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/child-fentanyl-exposure
**TGA
Decisions have been made on rescheduling of naproxen and paracetamol
combination products
https://www.tga.gov.au/book/interim-decisions-matters-referred-expert-advisorycommittee-acms-february-2015-11-16
These are aligned with recommendations made in NSW TAG's submission last year
http://www.ciap.health.nsw.gov.au/nswtag/members/docs/submissionsconsultations/2014/tga-acms-rescheduling-naproxen-sept-2014.pdf
REPORTS AND PUBLICATIONS – INTERNATIONAL
** CADTH
Development of Antibiotic Resistance to Norfloxacin in the Treatment of Urinary
Tract Infections: Clinical Evidence
http://www.cadth.ca/media/pdf/htis/feb2015/RA0732%20Norfloxacin%20for%20UTI%20Final.pdf
**FDA
FDA approves Lucentis (ranibizumab injection) to treat diabetic retinopathy in
patients with diabetic macular edema
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm433392.htm
**NICE
- Evidence summary: unlicensed or off-label medicine
-- Autoimmune haemolytic anaemia: rituximab [ESUOM39]
http://www.nice.org.uk/advice/esuom39
**Public Health England
Influenza: treatment and prophylaxis using anti-viral agents
https://www.gov.uk/government/publications/influenza-treatment-andprophylaxis-using-anti-viral-agents
MEDICATION SAFETY
**Health Canada
Safety Information: TECFIDERA (dimethyl fumarate) - Risk of Rare Brain Condition
Known as Progressive Multifocal Leukoencephalopathy (PML)
http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2015/43625a-eng.php
PAPERS OF INTEREST
**Circulation
Secondary Prevention After Coronary Artery Bypass Graft Surgery: A Scientific
Statement From the American Heart Association
http://circ.ahajournals.org/content/early/2015/02/09/CIR.0000000000000182?pap
etoc
**CMAJ
- Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking
spironolactone
http://www.cmaj.ca/content/early/2015/02/02/cmaj.140816
- with UKMi comment
http://www.medicinesresources.nhs.uk/en/Medicines-Awareness/PrimaryResearch/Other-primary-research/Trimethoprim-sulfamethoxazole-and-risk-ofsudden-death-among-patients-taking-spironolactone/
**Cochrane
- First-line drugs inhibiting the renin angiotensin system versus other first-line
antihypertensive drug classes for hypertension
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008170.pub2/full
- Rituximab for rheumatoid arthritis
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007356.pub2/full
- Effects of RAS inhibitors on diabetic retinopathy: a systematic review and metaanalysis
http://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)702566/abstract
**Eur J Clin Pharmacol
Identifying high-risk medication: a systematic literature review
http://www.ncbi.nlm.nih.gov/pubmed/24671697
**JAMA
Oral Iron Supplementation After Blood Donation: A Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2108889
Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson
Disease: A Randomized Clinical Trial
http://jama.jamanetwork.com/article.aspx?articleid=2108890
Treating Hypertension in Patients With Diabetes: When to Start and How Low to Go?
http://jama.jamanetwork.com/article.aspx?articleid=2108870
**JAMA Intern Med
- Statin Therapy and Risk of Fracture: Results From the JUPITER Randomized
Clinical Trial
http://archinte.jamanetwork.com/article.aspx?articleid=1936580
- Tramadol Use and the Risk of Hospitalization for Hypoglycemia in Patients With
Noncancer Pain
http://archinte.jamanetwork.com/article.aspx?articleid=1984249
**Joint Commission Journal on Quality and Patient Safety
Rethinking Critical Care: Decreasing Sedation, Increasing Delirium Monitoring, and
Increasing Patient Mobility
http://www.ingentaconnect.com/content/jcaho/jcjqs/2015/00000041/00000002/a
rt00003
**NEJM
Prehospital Use of Magnesium Sulfate as Neuroprotection in Acute Stroke
http://www.nejm.org/doi/full/10.1056/NEJMoa1408827
**Therapeutics Initiative
The limitations and potential hazards of using surrogate markers
http://www.ti.ubc.ca/letter92
TAG Mail 4th February 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**AIHW
Australian Burden of Disease Study: fatal burden of disease 2010
http://www.aihw.gov.au/publication-detail/?id=60129550176
**NSW Health
- Policy Directive
-- Human Immunodeficiency Virus (HIV) - Management of Non-Occupational
Exposure
http://www0.health.nsw.gov.au/policies/pd/2015/PD2015_005.html
-- Principles for Safe Management of Disturbed and /or Aggressive Behaviour and
the Use of Restraint
http://www0.health.nsw.gov.au/policies/pd/2015/PD2015_004.html
**NPS MedicineWise
LDL cholesterol: a surrogate supported
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/ldl-surrogates
REPORTS AND PUBLICATIONS – INTERNATIONAL
**CADTH
- Discontinuation Strategies for Patients with Long-term Z-drug Use: Clinical
Evidence and Guidelines
http://www.cadth.ca/media/pdf/htis/jan-2015/RA0727%20Zdrug%20Discontinuation%20Strategies%20Final.pdf
- Rituximab for Granulomatosis with Polyangiitis or Microscopic Polyangiitis: A
Review of the Clinical and Cost-effectiveness
http://www.cadth.ca/media/pdf/htis/feb2015/RC0631%20Rituximab%20for%20GPA%20or%20MPA%20Final.pdf
**EMA
EU report provides basis for effective fight against development of resistant
bacteria
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/01/news_detail_002260.jsp&mid=WC0b01ac058004d5c1
**FDA
- FDA approves Ibrance (palbociclib) for postmenopausal women with advanced
breast cancer
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm432871.htm
- FDA expands uses of Vyvanse (lisdexamfetamine dimesylate) to treat binge-eating
disorder
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm432543.htm
**NICE
- Evidence summary: new medicine
-- Chronic obstructive pulmonary disease: olodaterol [ESNM54]
http://www.nice.org.uk/advice/esnm54
-- Asthma in adults: beclometasone/formoterol dry powder inhaler (Fostair
NEXThaler) [ESNM53]
http://www.nice.org.uk/advice/esnm53
- Quality standard
-- Sarcoma [QS78]
http://www.nice.org.uk/guidance/qs78
-- Idiopathic pulmonary fibrosis [QS79]
http://www.nice.org.uk/guidance/qs79
**Tufts University
Cost to develop an approved new drug
http://csdd.tufts.edu/news/complete_story/pr_tufts_csdd_2014_cost_study
**UK Dept of Health
Improving care for people with dementia (updated, includes toolkit)
https://www.gov.uk/government/policies/improving-care-for-people-withdementia
**WHO
Global status report on noncommunicable diseases 2014
http://www.who.int/nmh/publications/ncd-status-report-2014/en/
MEDICATION SAFETY
**Health Canada
Cisplatin and venous thromboembolism
http://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2015-01eng.php#cisplatin
**ISMP
A critique of FDA’s key drug safety reporting system
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=100
**TGA
Medicines Safety Update, February 2015 includes: Combined oral contraceptives
and hormone replacement therapy - inflammatory bowel disease; Metoclopramide
and neurological adverse events; Publication changes for Medicines Safety Update
https://www.tga.gov.au/publication-issue/medicines-safety-update-volume-6number-1-february-2015
PAPERS OF INTEREST
**BMJ
The association between kidney function and major bleeding in older adults with
atrial fibrillation starting warfarin treatment: population based observational study
http://www.bmj.com/content/350/bmj.h246.full.pdf+html
**Circ Cardiovasc Qual Outcomes
Quantifying the Utility of Taking Pills for Cardiovascular Prevention
http://circoutcomes.ahajournals.org/content/early/2015/02/03/CIRCOUTCOMES.1
14.001240.abstract?papetoc
**JAMA
Diagnosis and Treatment of Clostridium difficile in Adults: A Systematic Review
http://jama.jamanetwork.com/article.aspx?articleid=2091993
**JAMIA
- Temporal and other factors that influence the time doctors take to prescribe
using an electronic prescribing system
http://jamia.oxfordjournals.org/content/22/1/206
- Electronic health records improve clinical note quality
http://jamia.oxfordjournals.org/content/22/1/199
**J Clin Endocrinol Metab
Drugs Commonly Associated With Weight Change: A Systematic Review and Metaanalysis
http://www.ncbi.nlm.nih.gov/pubmed/25590213
**Lancet
Oseltamivir treatment for influenza in adults: a meta-analysis of randomised
controlled trials
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)624491/abstract
**NEJM
- Adjuvant Ovarian Suppression in Premenopausal Breast Cancer
http://www.nejm.org/doi/full/10.1056/NEJMoa1412379
- Cost-Effectiveness of Hypertension Therapy According to 2014 Guidelines
http://www.nejm.org/doi/full/10.1056/NEJMsa1406751
**Pediatrics
- Morphine Versus Clonidine for Neonatal Abstinence Syndrome
http://pediatrics.aappublications.org/content/135/2/e383.abstract
- Cardiovascular Risk Factors in Children After Repeat Doses of Antenatal
Glucocorticoids: An RCT
http://pediatrics.aappublications.org/content/135/2/e405.abstract
- Morphine or Ibuprofen for Post-Tonsillectomy Analgesia: A Randomized Trial
http://pediatrics.aappublications.org/content/135/2/307.abstract
TAG Mail 28th January 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**NPS MedicineWise
Biosimilars: what's in a name?
http://www.nps.org.au/publications/health-professional/health-newsevidence/2015/naming-biosimilars
**NSW Health
- Safety information 00/15: E – Cigarettes, Oxygen Therapy, Burns and Fire Risk
http://www.health.nsw.gov.au/sabs/Documents/2015-si-001.pdf
- Policy Directive: Preventing and Managing Violence in the NSW Health Workplace A Zero Tolerance Approach
http://www0.health.nsw.gov.au/policies/pd/2015/pdf/PD2015_001.pdf
**TGA
- Orphan drugs added: Fomepizole
https://www.tga.gov.au/updates-list-designated-orphan-drugs
- Safety advisory: Lieel Icos Cialis tadalafil 80mg and 100mg and 'Top Gun for Men'
tablets pose a serious risk to your health
https://www.tga.gov.au/alert/lieel-icos-cialis-tadalafil-80mg-and-100mg-tablets
https://www.tga.gov.au/alert/top-gun-men-tablets
REPORTS AND PUBLICATIONS – INTERNATIONAL
**AHRQ
AHRQ Safety Program for End-Stage Renal Disease Facilities Toolkit (to help prevent
infection in people with end-stage renal disease)
http://www.ahrq.gov/professionals/quality-patient-safety/patient-safetyresources/resources/esrd/index.html
**CADTH
- Discontinuation Strategies for Patients with Long-Term Benzodiazepine Use:
Clinical Evidence and Guidelines
http://www.cadth.ca/media/pdf/htis/jan2015/RA0726%20BZD%20Discontinuation%20Strategies%20Final%20ABS.pdf
- Holkira (Ombitasvir/Paritaprevir/ Ritonavir with Dasabuvir) and Harvoni
(Ledipasvir/Sofosbuvir) for Chronic Hepatitis C: A Review of the Clinical Evidence
http://www.cadth.ca/media/pdf/htis/jan2015/RC0632%20Holkira%20and%20Harvoni%20Final.pdf
**EMA
Saxenda recommended for approval in weight management in adults
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/01/news_detail_002255.jsp&mid=WC0b01ac058004d5c1
**FDA
- FDA approves Natpara to control low blood calcium levels in patients with
hypoparathyroidism
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm431358.htm
- FDA approves first generic version of Nexium (esomeprazole magnesium delayedrelease capsules) to treat gastroesophageal reflux disease (GERD) in adults and
children ages 1 and older
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm431648.htm
- FDA approves new psoriasis drug Cosentyx (secukinumab)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm430969.htm
**NICE
- Quality standards
-- Urinary incontinence in women [QS77]
http://www.nice.org.uk/guidance/qs77
MEDICATION SAFETY
**EMA
- Central repository to facilitate assessment of medicines safety reports
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/01/news_detail_002257.jsp&mid=WC0b01ac058004d5c1
- New international standard to improve safety of medicines
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/01/news_detail_002252.jsp&mid=WC0b01ac058004d5c1
**HQSCNZ
- Reducing harm from falls downloadable resources: Ask, assess, act pocket card
http://www.hqsc.govt.nz/our-programmes/reducing-harm-from-falls/publicationsand-resources/publication/1025/
- Safe use of opioids national collaborative: Library of potential opioid-related
harms and measures
http://www.hqsc.govt.nz/assets/Medication-Safety/collaborative/PR/expertfaculty-measures-Jan-2015.pdf
**MHRA
- Stronger advice on the use of valproate medicines in women
http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON502625
- Drug Safety Update, January 2015 includes: Medicines related to valproate: risk of
abnormal pregnancy outcomes | Ustekinumab (Stelara): risk of exfoliative
dermatitis | Mycophenolate mofetil (CellCept) and mycophenolic acid: risk of
hypogammaglobulinaemia and risk of bronchiectasis | Aceclofenac (Preservex):
updated cardiovascular advice in line with diclofenac and COX-2 inhibitors
https://www.gov.uk/drug-safety-update
PAPERS OF INTEREST
**BMJ
Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a
systematic review and meta-analysis
http://www.bmj.com/content/350/bmj.h102
**Cochrane
- Are shorter courses of systemic steroids as effective as conventional longer
courses in the treatment of patients with flare-ups of COPD?
http://summaries.cochrane.org/CD006897/AIRWAYS_are-shorter-courses-ofsystemic-steroids-as-effective-as-conventional-longer-courses-in-the-treatment-ofpatients-with-flare-ups-of-copd
- The relative safety and effectiveness of different epoetin drugs for treating
anaemia in people with chronic kidney disease
http://summaries.cochrane.org/CD010590/RENAL_the-relative-safety-andeffectiveness-of-different-epoetin-drugs-for-treating-anaemia-in-people-withchronic-kidney-disease
**JAMA Intern Med
Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective
Cohort Study
http://archinte.jamanetwork.com/article.aspx?articleid=2091745
**JAMIA
- A novel method of adverse event detection can accurately identify venous
thromboembolisms (VTEs) from narrative electronic health record data
http://jamia.oxfordjournals.org/content/22/1/155
- Effects of electronic health record use on the exam room communication skills of
resident physicians: a randomized within-subjects study
http://jamia.oxfordjournals.org/content/22/1/192
**Lancet
- Optimum and stepped care standardised antihypertensive treatment with or
without renal denervation for resistant hypertension (DENERHTN): a multicentre,
open-label, randomised controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)619425/abstract
- HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence
from genetic analysis and randomised trials
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)611831/abstract
**Pediatrics
- Potential Drug−Drug Interactions in Infant, Child, and Adolescent Patients in
Children’s Hospitals
http://pediatrics.aappublications.org/content/135/1/e99.abstract
- Anaerobic Antimicrobial Therapy After Necrotizing Enterocolitis in VLBW Infants
http://pediatrics.aappublications.org/content/135/1/e117.abstract
TAG Mail 21st January 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**NPS-MedicineWise
NPS Direct, January 2015 includes: Antibiotics in infancy linked to childhood obesity
| Oxycodone deaths: abuse not the only cause
http://www.nps.org.au/health-professionals/e-newsletters/nps-direct
**TGA
- AusPARS added: Aripiprazole monohydrate (Abilify maintena), Canakinumab
(Ilaris), Enzalutamide (Xtandi), Fenofibrate (Lipidil)
https://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars
- Submissions received: Medicine labelling
https://www.tga.gov.au/submissions-received-medicine-labelling
- Evaluation (and naming conventions) of biosimilars
https://www.tga.gov.au/evaluation-biosimilars
REPORTS AND PUBLICATIONS – INTERNATIONAL
**MHRA
Diclofenac tablets now only available as a prescription medicine
http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON500341
**NHS
Exploring the costs of unsafe care in the NHS. A report prepared for the
Department of Health
http://www.frontier-economics.com/documents/2014/10/exploring-the-costs-ofunsafe-care-in-the-nhs-frontier-report-2-2-2-2.pdf
**NICE
- Evidence summary: new medicine
-- Chronic obstructive pulmonary disease: umeclidinium inhaler (Incruse) [ESNM52]
http://www.nice.org.uk/advice/esnm52
- Key therapeutic topics updated and include:
-- Antibiotic prescribing – especially broad spectrum antibiotics [KTT9]
http://www.nice.org.uk/advice/ktt9
-- First-choice antidepressant use in adults with depression or generalised anxiety
disorder [KTT8] http://www.nice.org.uk/advice/ktt8
http://www.nice.org.uk/advice
MEDICATION SAFETY
**Health Canada
MedEffect notice: Domperidone Maleate - Association with Serious Abnormal Heart
Rhythms and Sudden Death (Cardiac Arrest)
http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2015/43423a-eng.php
**ISMP
Technology and error-prevention strategies: Why are we still overlooking the IV
room?
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=98
**TGA
Safety advisory: Power 1 tablets pose a serious risk to your health and should not be
taken
https://www.tga.gov.au/alert/power-1-tablets
PAPERS OF INTEREST
**Am J Health-Syst Pharm
- Development of an inpatient operational pharmacy productivity model
http://www.ajhp.org/content/72/3/206.abstract
- Impact of incorporating pharmacy claims data into electronic medication
reconciliation
http://www.ajhp.org/content/72/3/212.abstract
**BMJ Open
Prescriber barriers and enablers to minimising potentially inappropriate
medications in adults: a systematic review and thematic synthesis
http://bmjopen.bmj.com/content/4/12/e006544.abstract
**BMJ Qual Saf
Computerised physician order entry-related medication errors: analysis of reported
errors and vulnerability testing of current systems
http://qualitysafety.bmj.com/content/early/2015/01/16/bmjqs-2014-003555
**Cochrane
- Use of rapid point-of-care testing for infection to guide doctors prescribing
antibiotics for acute respiratory infections in primary care settings
http://summaries.cochrane.org/CD010130/ARI_use-of-rapid-point-of-care-testingfor-infection-to-guide-doctors-prescribing-antibiotics-for-acute-respiratoryinfections-in-primary-care-settings
- Can electronic cigarettes help people stop smoking or reduce the amount they
smoke, and are they safe to use for this purpose?
http://summaries.cochrane.org/CD010216/TOBACCO_can-electronic-cigaretteshelp-people-stop-smoking-or-reduce-the-amount-they-smoke-and-are-they-safe-touse-for-this-purpose
**International Journal for Quality in Health Care
- What are incident reports telling us? A comparative study at two Australian
hospitals of medication errors identified at audit, detected by staff and reported to
an incident system
http://intqhc.oxfordjournals.org/content/early/2015/01/12/intqhc.mzu098
- Multicentre study to develop a medication safety package for decreasing inpatient
harm from omission of time-critical medications
http://intqhc.oxfordjournals.org/content/early/2014/12/22/intqhc.mzu099
**JAMA Intern Med
- Out-of-Hospital Mortality Among Patients Receiving Methadone for Noncancer Pain
http://archinte.jamanetwork.com/article.aspx?articleid=2091400
- Dietary Sodium Content, Mortality, and Risk for Cardiovascular Events in Older
Adults: The Health, Aging, and Body Composition (Health ABC) Study
http://archinte.jamanetwork.com/article.aspx?articleid=2091399
- Association of Amiodarone Use With Acute Pancreatitis in Patients With Atrial
Fibrillation: A Nested Case-Control Study
http://archinte.jamanetwork.com/article.aspx?articleid=2091397
- Orders for Intravenous Proton Pump Inhibitors After Implementation of an
Electronic Alert
http://archinte.jamanetwork.com/article.aspx?articleid=2091396
- Falls and Fractures With Atypical Antipsychotic Medication Use: A PopulationBased Cohort Study
http://archinte.jamanetwork.com/article.aspx?articleid=2089230
**J Clin Endocrinol Metab
Pharmacological Management of Obesity: An Endocrine Society Clinical Practice
Guideline
http://press.endocrine.org/doi/pdf/10.1210/jc.2014-3415
**Lancet
- The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised openlabel masked endpoint clinical trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)624569/abstract
- Adjunct prednisone therapy for patients with community-acquired pneumonia: a
multicentre, double-blind, randomised, placebo-controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)624478/abstract
- Efficacy and safety of LDL-lowering therapy among men and women: metaanalysis of individual data from 174 000 participants in 27 randomised trials
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)613684/abstract
**Lancet Neurol
Pharmacotherapy for neuropathic pain in adults: a systematic review and metaanalysis
http://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2814%29702510/abstract
**NEJM
Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis
http://www.nejm.org/doi/full/10.1056/NEJMoa1405760
TAG Mail 14th January 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
Nil
REPORTS AND PUBLICATIONS – INTERNATIONAL
**British Government-Wellcome Trust
Review on Antimicrobial Resistance
http://amr-review.org/
**EMA
EMA approves Lynparza (olaparib), Vargatef (nintedanib)
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicin
es/003726/human_med_001831.jsp&mid=WC0b01ac058001d124
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicin
es/002569/human_med_001822.jsp&mid=WC0b01ac058001d124
**FDA
FDA approves anti-clotting drug Savaysa (edoxaban tablets)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm429523.htm
**RAND Corporation
Estimating the economic costs of antimicrobial resistance
http://www.rand.org/pubs/research_reports/RR911.html
**KPMG
The global economic impact of anti-microbial resistance
https://www.kpmg.com/UK/en/IssuesAndInsights/ArticlesPublications/Documents/
PDF/Issues%20and%20Insights/amr-report-final.pdf
**NICE
Gastro-oesophageal reflux disease: recognition, diagnosis and management in
children and young people [NG1]
http://www.nice.org.uk/guidance/ng1
MEDICATION SAFETY
**EMA
PRAC considers risk of severe allergic reactions with ambroxol- and bromhexinecontaining medicines to be small
http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20
15/01/news_detail_002248.jsp&mid=WC0b01ac058004d5c1
**FDA
Drug Safety Communication: FDA has reviewed possible risks of pain medicine use
during pregnancy
http://www.fda.gov/Drugs/DrugSafety/ucm429117.htm
with Podcast
http://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm430053.htm
PAPERS OF INTEREST
**Am J Clin Oncol
Interaction of Salicylates and the Other Nonsteroidal Anti-Inflammatory Agents With
Breast Cancer Endocrine Treatment: Systematic Review
http://www.ncbi.nlm.nih.gov/pubmed/25503435
**Ann Intern Med
- The Effectiveness and Risks of Long-Term Opioid Therapy for Chronic Pain: A
Systematic Review for a National Institutes of Health Pathways to Prevention
Workshop
http://annals.org/article.aspx?articleID=2089370
- Position paper: National Institutes of Health Pathways to Prevention Workshop:
The Role of Opioids in the Treatment of Chronic PainThe Role of Opioids in the
Treatment of Chronic Pain
http://annals.org/article.aspx?articleID=2089371
**BMJ Qual Saf
Systematic review: Key characteristics of successful quality improvement curricula
in physician education: a realist review
http://qualitysafety.bmj.com/content/24/1/77.short?g=w_qs_current_tab
TAG Mail 7th January 2015
REPORTS AND PUBLICATIONS - AUSTRALIA
**AIHW
- Staphylococcus aureus bacteraemia in Australian public hospitals 2013–14:
Australian hospital statistics
http://www.aihw.gov.au/publication-detail/?id=60129550044
- Cardiovascular disease, diabetes and chronic kidney disease: Australian facts:
morbidity—hospital care
http://www.aihw.gov.au/publication-detail/?id=60129550063
- Health expenditure Australia 2012–13: analysis by sector
http://www.aihw.gov.au/publication-detail/?id=60129550083
**NPS-MedicineWise
Antibiotics in infancy linked to childhood obesity
http://www.nps.org.au/publications/health-professional/health-newsevidence/2014/infancy-antibiotics-obesity
**NSW Health
- 2014 Policy Directives & Guidelines
-- Guidelines for the Management of Substance Use During Pregnancy Birth and the
Postnatal Period
-- Infants and Children: Management of Acute Gastroenteritis, Fourth Edition
-- Principles for the Management of Tuberculosis in New South Wales
http://www0.health.nsw.gov.au/policies/date/2014.asp
- Building a sustainable health workforce for rural NSW
http://www.health.nsw.gov.au/rural/Pages/building-sustainable-workforce.aspx
**TGA
Orphan drugs added Factor XI Concentrate (human coagulation factor XI)
http://www.tga.gov.au/updates-list-designated-orphan-drugs
REPORTS AND PUBLICATIONS – INTERNATIONAL
**CADTH
- Rapid responses
-- Dexmedetomidine for Sedation in the ICU or PICU: A Review of Cost-Effectiveness
and Guidelines
-- Intravenous Administration of Medications in Home Care Settings: Clinical
Evidence and Guidelines
http://www.cadth.ca/en/products/rapid-response
**FDA
- FDA approvals:
-- weight-management drug Saxenda (liraglutide [rDNA origin] injection)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427913.htm
-- Opdivo (nivolumab) for advanced melanoma
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427716.htm
-- Rapivab (peramivir) to treat flu infection
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427755.htm
-- Lynparza (olaparib) to treat advanced ovarian cancer
http://www.fda.gov/Drugs/NewsEvents/ucm130958.htm
-- new antibacterial drug Zerbaxa (ceftolozane/tazobactam)
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427534.htm
**NICE
- Evidence Update
-- Hyperphosphataemia in chronic kidney disease, December 2014
http://arms.evidence.nhs.uk/resources/hub/1041123/attachment
- Evidence summary: new medicine
-- Hyperphosphataemia in adults with chronic kidney disease on dialysis: sucroferric
oxyhydroxide [ESNM51]
http://www.nice.org.uk/advice/esnm51
- Quality standards
-- Antibiotics for neonatal infection [QS75]
http://www.nice.org.uk/guidance/qs75
-- Acute kidney injury [QS76]
http://www.nice.org.uk/guidance/qs76
MEDICATION SAFETY
**ISMP
Tragic error with neuromuscular blocker should prompt risk assessment by all
hospitals
http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=97
**MHRA
Drug safety update, December 2014 includes: Ivabradine (Procoralan) in the
symptomatic treatment of angina: risk of cardiac side effects—new advice to
minimise risk | Isotretinoin (Roaccutane): reminder of possible risk of psychiatric
disorders—warn patients and family; monitor patients for signs of depression |
Hydroxyethyl starch intravenous infusions to be used only in patients with acute
blood loss and when crystalloids alone are not sufficient
http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/index.htm
PAPERS OF INTEREST
**Am J Health-Syst Pharm
- Effect of computerized prescriber order entry on pharmacy: Experience of one
health system
http://www.ajhp.org/content/72/2/133.abstract
**Ann Intern Med
- Valganciclovir for the Prevention of Complications of Late Cytomegalovirus
Infection After Allogeneic Hematopoietic Cell Transplantation: A Randomized
TrialLate CMV Prevention After HCT
http://annals.org/article.aspx?articleid=2088543
- Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis:
A Systematic Review and Network Meta-analysisPharmacologic Interventions for
Knee OA
http://annals.org/article.aspx?articleid=2088548
- Effects of Blood Pressure Reduction in Mild Hypertension: A Systematic Review
and Meta-analysis
http://annals.org/article.aspx?articleid=2085847
**BMJ Qual Saf
Adverse events in patients with return emergency department visits
http://qualitysafety.bmj.com/content/early/2014/12/24/bmjqs-2014003194.short?g=w_qs_ahead_tab
**Cochrane Collaboration
- Different durations of corticosteroid therapy for exacerbations of chronic
obstructive pulmonary disease
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006897.pub3/abstract;jse
ssionid=B89364C93CAAF59E71F14C84F72F37C4.f04t01
- Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney
disease: a network meta-analysis
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010590.pub2/abstract
**JAMA Intern Med
- Secondary Prevention of Cardiovascular Disease With Vorapaxar: A New Era of 3Drug Antiplatelet Therapy?
http://archinte.jamanetwork.com/article.aspx?articleid=1921757
- Risk of Bleeding With Dabigatran in Atrial Fibrillation
http://archinte.jamanetwork.com/article.aspx?articleid=1921753
- Medication Therapy Management Interventions in Outpatient Settings: A
Systematic Review and Meta-analysis
http://archinte.jamanetwork.com/article.aspx?articleid=1935933
**MJA
Australia-wide point prevalence survey of the use and appropriateness of
antimicrobial prescribing for children in hospital
https://www.mja.com.au/journal/2014/201/11/australia-wide-point-prevalencesurvey-use-and-appropriateness-antimicrobial
**Pediatrics
- Anaerobic Antimicrobial Therapy After Necrotizing Enterocolitis in VLBW Infants
http://pediatrics.aappublications.org/content/135/1/e117.abstract
- Antimicrobial Stewardship Programs in Freestanding Children’s Hospitals
http://pediatrics.aappublications.org/content/135/1/33.abstract
- Off-Label Prescribing in Pediatric Outpatients
http://pediatrics.aappublications.org/content/135/1/49.abstract