Teaching plan of bilingual teaching
双语教学教案
Gannan Medical College
Department of pathogenic Biology
Teacher
（教师）
Date
（日期）
Grade
（年级）
Speciality
专业
Lecture type
(授课类型)
Clinical medical
(临床医学)
chapters and sections
(授课章节)
Chapter 17 Mycoplasma
Chapter 18 Chlamydiae
Chapter 19 Rickettsia
Objective and request
教学目的和要求
1.
2.
3.
4.
5.
Emphasis and difficulty
授课重点、难点
Reference teaching material
参考教材
Teaching aid
媒体与教具
Theory Course
(理论课)
Subject
（课程）
Class hour
（学时）
Medical Microbiology
医学微生物学
Master the characters of mycoplasma
Master the pathogenic mycoplasma
Master the characteristics of chlamydiae
Master the common characteristics of Rickettsiae
Master the disease caused by Rickettsiae and the transmitted way
1. The characters of mycoplasma
2. The characteristics of chlamydiae
3. the common characteristics of Rickettsiae
1．周正任主编.《医学微生物学》第 6 版
2．Medical microbiology(21 edition, Jawetz, Melnick, and Adelberg)
Powerpoint
Teach contents（教学内容）
Chapter 17
Mycoplasma
I . Introduction
1.the smallest free-living prokaryotic organisms that can grow in artificial media.
2. distributed extensively --Human, animals, plants, insects and sewage.
3. Non-cell wall, pleomorphic.
3. pleuro-pneumonia-like organisms—PPLOⅡ
II..Biological properties
1. size:
2. three layer of membrane:
3. terminal structure:
4. Propagation pattern: binary fission
5. Both DNA and RNA
6. culturefried-egg colony:
7. classification
1
2 hours
(1) Mycoplasmataceae: mycoplasma , Ureaplasma
(2) Acholeplasmataceae
(3) Spiroplasmataceae9. Resistant resistant to penicillin, polymyxinsensitive to tetracycline,
Ⅲ. Pathogenicity
1.M. pneumoniae[MP]
2.Ureaplasma urealyticum [UU]
Chapter 17 Chlamydia
I.Biological properties
1. small non-motile prokaryotic microbes, filterable (0.2-0.4um) ,
2. cell wall, G- similar to G- bacillus,
3.contain DNA and RNA ,
4.obligate intracellular parasite,
5.unique life-cycle ,
6.classification,
1)Chlamydia trachomatis
(1) biovar trachoma : 14 serotypes(A-K )
(2) biovar lymphogranuloma Venereun(LGV):4 serotypes(L1, L2, L2a,L3 )
(3) biovar mouse
2) Chlamydia pneumoniae: 1 serotype
3) Chlamydia psittaci
Ⅱ. Pathogenicity
1.pathogenic factor :
(1) surface structure
(2) endotoxin -like substance
2.Disease
(1) C.trachomatis
① Trachoma
② Inclusion Conjunctivitis
③ Genital-tract infection –NGU
④ Lymphogranuloma Venereun (LGV)
(2) C. pneumonia
infantile pneumonia
Chapter 19 Rickettsia
Ⅰ Biological properties
1. small G- bacilli,
2. Giemsa stain: violet or blue;
3.They are obligated intracellular parasites ;
4. binary fission ;
2
5. have both DNA and RNA;
6. Culture:
susceptible animal (guinea pig),
yolk sac of chick embryo,
cell culture;
7. through the bite or feces of an infected arthropod vector.
8. resistance: week, sensitive to antibiotic
9. Antigen: type-specific Ag-- stimulate antibody
10. weil-Felix reaction
Proteins: Proteus strains OX-2, OX-19, OX-K
tilter:>1:160 and progressive rise
11.Classification:
(1) Typhus group : Epidemic typhus (R.prowazekii)
Endemic typhus (R. mooseri)
(2) Spotted fever group
(3) Tsutsugamushi group
Epidemic typhus (R.prowazekii)
(1) louse-borne ; substandard living condition, poor sanitation; overwhelming bacterimia
(2) transmitted way
(3) fever(temperature rises to 40℃);
(4) treatment: sanitation, eradication of human lice; vaccine , tetracycline
Endemic typhus(R. mooseri)
(1) flea-borne;
(2) murine typhus
(3) transmitted way :
II.Pathogenicity
Rickettsiae diseases are transmitted from animal to animal by the bite of an arthropod vector .Rickettsia
disseminated through the bloodstream, enter endothelial cells by induced phagocytosis escape from the
phagosome, intracellular multiply and eventually destroy their host cell
question
思考题
3