1
H. U. MAY:
Facts and hypotheses concerning the causal or symptomatic therapeutic
use of currents in oncology - direct and indirect effects upon cells,
tissues and the whole organism.
The possibilities to optimize the efficacy of currents by variation or
fixation of their parameters in dependence on the intended therapeutic
purpose.
Introduction
concerning the history of therapeutic use of currents for the treatment of tumor
patients
Already in the middle of the 18th century the two German physicists HAUSEN & WINKLER
tried with their electrical machine, based on friction, to treat tumors. After the spreading of
the inventions of GALVANI (1737 - 1798) and VOLTA (1745 - 1827) since the 19th century
electricity has been used more frequently to treat tumor patients. Not only symptomatic
treatments for pain relief but even mainly causal treatments consisting in trials to destroy the
tumors were usual. In standard dictionaries and encyclopedias from the second part of the 19th
century and the first decades of the 20th century you can find very much more general
information and special description of the electrolytic destruction of tumors by direct currents
under the catchword “electrotherapy” than in the second part of the 20th century and today.
Until today the galvanic current as the primarily preferred current in the causal treatment of
tumor patients is used in various clinics and hospitals, for instance in Austria according the
recommendations of PEKAR given in his 3 books about the percutaneous galvanotherapy in
cases of tumors, published since 1988, basing on experiences since 1977. Also in Sweden
NORDENSTRÖM used direct currents (DC) for the treatment of tumors, basing on his theory
of “biologically closed electric circuits” (1983). The DC method requires needles to be placed
inside the tumor. It is an invasive method. I know, that in Germany, Denmark, Italy and China
in special hospitals this invasive DC method is in use, however in Germany without public
advertising.
Just before the 1st world war VERAGUTH & SEYDERHELM (1913 and 1914, Zürich and
Straßburg) found the tendency of various direct and alternating currents, applied as whole
body treatments in a “4 cell bath”, to reduce the number of white blood cells in leukemia
patients. The histories of RIFE’s work in the United States and independently from him of
LAKHOVSKY’s work in France concerning cancer treatment using alternating electrical
fields of various frequencies are well described in the “RIFE Report”, written by Barry
LINES and published 1987, and in LAKHOVSKY’s “Secret of life”, published the first time
1929.
“Tone frequency currents”, a not very precise term introduced by KOEPPEN 1935 in his
paper “Tone frequency currents in medicine”, has been changed 1944 by the German
physiologist GILDEMEISTER in Leipzig into the term “middle frequency currents” (MF),
defined by the frequency range between 1000 Hz and ca. 100 kHz. GILDEMEISTER and his
pupil SCHWARZ, furthermore WYSS in Zürich, investigated the very interesting and special
advantageous physiological properties of these MF currents, however more from the
standpoint of physiology as a thoretical field of medicine than with a practical therapeutic
view. Consequently, they did not take into account any thoughts concerning the effects of MF
upon tumors.
2
Without any knowledge about the publications concerning MF currents published mainly in
journals of physiology the electronic engineer doctor NEMEC from Austria in the late 40s up
to 1952 used MF currents between 4000 and 4100 Hz for his invention of “interferential
current”, realized by the company NEMECTRON as the “Nemectrodyn” machine.
Dr. Hanna FRESENIUS, a female general practitioner in Steinau in Hessen (Germany) was
one of the first medical doctors, who experienced the wide range of indications of the new
equipment including pain relief in cancer patients. Additionally she observed in the majority
of the patients not only pain relief but additionally a general increase of their condition, of
their quality of life, in some of the patients even an inhibition of the tumor growth or a
shrinking of the tumor. After several years of successful treatments of cancer patients with
these interferential currents other medical doctors, competitors which were not familiar with
the new treatment, suggested a damning of the new electrotherapeutic method in cancer
patients by the regionally responsible professional instance. Dr. Hanna FRESENIUS was not
agree. She moved with her practice to Bavaria and pursued successfully to treat cancer
patients but more secretly.
Convinced by the beneficial effects of interferential currents in cancer patients she initiated
animal experiments together with the university of Freiburg. She fed two groups of rats with
the carcinogeneous “butter yellow” (dimethylaminoazobenzol). One group was treated nearly
everyday with interferential current.
Only the animals of the other group developed liver tumors. In this time I was as a
neurologist, physiologist and pharmacologist with long experiences in biomedical engineering
and biocybernetics in the University of Karlsruhe a member of the medical-scientific
department of Nemectron in Karlsruhe, responsible for all theoretical and practical medical
questions.
With monetary, technical and scientific support by Nemectron and with prepared rats from
Prof. F. SCHMIDT (Institute for Preventive Oncology of the University HeidelbergMannheim) she started new series in rats suffering from chemically induced subcutaneous
tumors. When the tumors were detected early enough and the diameter of the tumor was not
larger than 8 to 10 mm, the treatments with interferential current (carrier frequencies around
4000 Hz) leaded to a shrinking and finally to a disappearance of the tumors. Larger tumors
did not disappear. They sustained to grow, partially up to the size of apples, and the tumors
seemed to cause intensive itch sensations. The rats injured the skin around the subcutaneous
tumor and finally the tumor itself. The initially solid tumor had changed to a cyst filled with a
fluid. The cyst opened by the teeth of the rat collapsed, was infected, and the rat died within
hours or few days.
These kinds of animal experiments could not be continued because of a new law concerning
the use of animals for scientific research.
Therefore, with financial support by the German Ministry for Research and Technology in the
laboratories of Nemectron and 4 institutes of the medical faculties of various universities and
scientific centers (Freiburg, Aachen, German Cancer Research Center Heidelberg, German
Nuclear Research Center Karlsruhe) investigations concerning the influences of middle
frequency currents were carried out with normal and various tumor cells. In 2 doctor
dissertations (M. NOSZVAI-NAGY, Karlsruhe, 1993/94, W. PETROW, Aachen, 1988), in
lectures and papers on a symposium in Karlsruhe, 1990, and a German Cancer Congress in
Hamburg 1994 the results were presented.
The most important results were:
1. Some kinds of tumor cells in vitro can be killed during the application of middle
frequency currents (with frequencies in the lower MF range, mainly 4000 Hz); they
suddenly disappear by destruction of their cell membrane. Abnormal large cells
3
appear to be more sensitive. However, not all types of the tumor cells had the same
sensitivity.
2. MF currents can facilitate the growth of normal fibroblasts in dependence on the
strength of the electric field.
3. MF currents can influence the adenylcyclase resulting in changes of the intracellular
cAMP formation, that means MF currents can have hormone-like effects. This
corresponds with the results of other authors.
4. MF currents can cause an increase of the number and the size of mitochondria.
5. Alternating electric fields within the MF range facilitate and consequently accelerate
the diffusion along the lines of the electric fields – in the two opposite directions.
This result was predictable due to physical, electrochemical and statistical
considerations.
The cell culture research program supported by the German government unfortunately could
not be continued because of monetary restrictions. Additional psychological problems
between the supervisory board and the leading management caused repetitive changes within
the top management team. Finally the owner of Nemectron, the margrave of Baden, had to
sale his company. After few years the ownership changed again.
My own experiences with interferential current (MF between 4000 and 4100 Hz) as a
neurologist – not an oncologist – in tumor patients were different. Some examples:
Tumor
Result
Astrocytoma
Glioblastoma
No success
No success.
Chordoma
Stop of the growth of the tumor for many years, but not
destruction
Patient was found dead in his bed in the morning after a
long evening of a festival during his vacation in Spain.
Melanoma with metastases
in the central nervous system,
earlier and larger in the spinal
cord resulting in paraplegia,
later and smaller in the medulla
oblongata causing dizziness
and circulatory disturbances
The same patient suffered since
his early childhood from multiple
benignant tumors of the fatty
Slowing of growth
Not treatable
In general: Significant pain relief, reduction of the
analgesic drugs, enhancement of the quality of life,
6 months prolongation of the survival time, life at home
with his family instead of an immediate death under
high dosages of narcotics at the intensive care station of
the Dermatological department of the University of Köln.
4
tissue, lipomas, disseminated to
the whole body, rump and limbs.
All the lipomas disappeared within few weeks after
the begin of the daily electrical treatments.
1981 THIESS & DIETRICH in Heilbronn and 1994 KUKLINSKI in Rostock also reported
conspicuous beneficial however finally not healing effects in tumor patients treated with
interferential currents.
In KUKLINSKI’s study a group of 37 patients received interferential current (IFC) treatment
twice per day. Modulation frequency was scanned between 0.5 and 150 Hz.
Results:
Partial remissions were observed in patients with superficial cutaneous metastases or
ulcerative mammary carcinomas (n=3).
Tumor progression was lowered in 2 patients with pancreatic carcinomas.
Responses of tumors of the pulmonary and bowel tracts were generally poor.
In many cases, a considerable reduction of inconveniencies associated with the disease was
noted (e.g. reduction of pain, rapid improvement of physical condition, etc.)
Conclusion: In order to improve the response of malignant tumors, particularly of deep-lying
tumors, hitherto existing parameters and strategies of IFC-treatment seem to require revision.
Taking into account the fact that in cell culture experiments and in patients the desired effects
of MF currents seemed to be dependent on the type of the tumor, the question arose:
Is the sensitivity of the special type of tumor cells dependent on the frequency of the MF
current? This was the origin of my idea to use the modulation of the frequency in a
mathematically continual way over a wide range in accordance with the technical and
legitimate possibilities, avoiding arbitrary irregular and to large steps and to minimize the
differences between the theoretically optimum frequency and the really generated frequency.
Additionally the electrical, neurophysiologic and psychophysical possibilities concerning the
intensities of the applied frequency-dependent currents should be optimized. The distance to
local and systemic tolerance limits should be as large as possible to maximize the therapeutic
width.
Since 2000 my idea of simultaneous modulation of frequency and amplitude (SimulFAM®)
adaptable to the individual and local frequency-dependent threshold of sensation is realized
and available until now in Europe and Asia as HiToP®, High Tone Power Therapy. (MAY,
2002 and 2004).
The manufacturer is the company gbo, “Gerätebau Odenwald”, manufacturing and distributing too
still traditional low-frequency and interferential electrotherapy units of Siemens.
The frequency is modulated in quarter tone steps between 212 and 215 Hz (4096 and
32768 Hz).
With 73 frequencies (“tones” in the high tone and low ultrasound ranges) 3 octaves are
covered. The maximum distance to a theoretically optimum frequency or to a frequency in an
harmonic relation to this optimum frequency is 1/8 tone step corresponding 2-48.
Facts and hypotheses concerning the causal or symptomatic therapeutic use of
currents in oncology - direct and indirect effects upon cells, tissues and the
whole organism.
Causal therapeutic use
Facts:
5
Some facts as results of experimental studies are already itemized in the introduction under
number 1 – 5.
Hypotheses
regarding inhibitory effects of unmodulated, amplitude-modulated and simultaneously
frequency- and amplitude-modulated middle frequency currents
upon tumor growth
Direct effects of currents upon transformed cells
Changes and renormalizations of pathological processes in tumor cells, caused
by stimulatory and multi-facilitatory (electro-biochemical, non-stimulatory)
effects
induced by electrically triggered molecular conformation changes within the
cell membrane, that means a kind of simulation of hormone effects, resulting in
the (normalization of) formation of intracellular second messengers, for
example cyclic AMP
induced by capacitively coupled effects
through the cell membrane into the intracellular space (cytosol),
through the outer mitochondrial membrane into the intermembrane space and
through the inner mitochondrial membrane into the mitochondrial matrix,
for instance
multi-facilitatory effects upon the metabolism:
facilitation of diffusion processes
facilitation of enzymatically mediated processes of the intracellular
metabolism, basing on
the increase of the kinetic energy of molecules involved in metabolic
processes, lowering the differences to the required activation energy,
the increase of the probability of the events of the important accidental
meetings between enzyme and substrate,
the increase of the probability of the events of the important accidental
meetings between enzyme and substrate in the correct position
(according to DAFFORN & KOSHLAND: A. DAFFORN & D. E. KOSHLAND jr.,
Biochem. Biophys. Res. Commun. 52, 780, (1973) )
direct influences upon the transport mechanisms of protons and electrons
within the inner membrane of the mitochondria
6
preference of the aerobic metabolic pathways instead of the anaerobic
glycolysis
induced by direct influence upon the intercellular communication ("cleaning
effect" concerning ion channels including gap junctions), resulting in
partial or total recovery of the disturbed electrical and chemical
communication between tumor cells mutually and between tumor cells and
the cells in the adjacent tissue (one step to a redifferentiation)
partial or total recovery of the disturbed metabolic cooperation between
tumor cells mutually and between tumor cells and the cells in the adjacent
tissue (a second step to a redifferentiation)
partial or total recovery of the disturbed functional coordination between
tumor cells mutually and between tumor cells and the cells in the adjacent
tissue (a third step to a redifferentiation)
partial or total recovery of the disturbed probably electrically mediated
control of the target of the normal topographic-anatomical and
histological structure of the referred body region (last step and desired
main goal of redifferentiation)
Over-stress of the pathologically changed metabolism of the tumor cell,
caused by frequently generated depolarization and the required
repolarization (stimulatory effect, possible with supra-threshold intensities
only)
Indirect effects
Primary effects:
Activation of cells of the immune system
by means of sustained depolarization (non-stimulatory effect) of the
involved cells of the immune system, causing an increase of cell division
rates of normal cells which are able to increase their mitotic activity if such
increase is required,
by means of cyclic AMP formation (non-stimulatory multi-facilitatory and
stimulatory effect) within the involved cells of the immune system,
by facilitation of intercellular communication (non-stimulatory multifacilitatory effect)
by an
increase
of
generation
of
natural
killer
cells
(NKC),
observed by KUKLINSKI as a result of stimulatory effects, probably possible with
non-stimulating currents too.
Enhancement of the efficacy of the activity of the cells of the immune system
in the neighborhood of the tumor by means of the equilibratory effect upon
7
concentration differences normalizing the pH values.
Due to the preference of the anaerobic metabolism in tumor cells with an increase of
lactic acid production the pH is lowered in the extracellular space within the tumor and
in it’s neighborhood; the lowered pH is impairing the function of the cells of the immune
system.
Partial or total recovery of the disturbed communication between the “asocial”
cells of the tumor takes place by means of the electrochemical shaking effect.
Stimulation of the sympathetic nervous system (stimulatory effects)  release of
transmitters (mainly nor-epinephrine) from the varicosities of the sympathetic
nerve endings  reduction of inflammatory tissue changes in the neighborhood
of the tumor  activation of receptors within the cell membranes involved in the
tumor growth inhibiting processes.

Secondary effects:
The activation of cells of the immune system could result in the following
secondary effects:
Increase of phagocytosis
Increase of the release of mediators acting as inhibitors of tumor growth or even
as tumor cell destroying agents (for instance tumor necrosis factor)
Symptomatic therapeutic use
The symptomatic therapeutic use concerns mainly
1. pain relief,
2. edema reduction
3. prevention of venous thromboses
4. reduction of the required dosage of pain relieving and other drugs with
reduction of their side effects
5. inhibition of cachexia by -mimetic effects
6. general enhancement of the quality of life
The possibilities to optimize the efficacy of currents by variation or fixation of their
parameters in dependence on the intended therapeutic purpose
1. Pain relief
Five pain relieving effects are available:
a. Distribution and thinning of mediators of pain and inflammation
b. “Real nerve block” by reversible sustained partial depolarization, “plateau effect”
c. ”Pseudo block” associated with “tea”, transient excitatory activity
d. Counter-irritation (GAMMON & STARR, 1941) and  -endorphin release
e. In cases of painful swellings indirect causal pain relief by edema reduction
The following parameters should be preferred:
8
a. High intensities during blocks with higher fixed frequencies (max. 215 Hz)
or SimulFAM along the threshold curve, SimulFAMi
b. Maximum tolerable intensity with higher fixed frequencies (max. 215 Hz)
c. High intensity with higher fixed frequencies (max. 215 Hz)
d. SimulFAMX with crossing of the threshold curve, frequency of modulation 100 Hz
e. SimulFAMX with crossing of the threshold curve, frequency of modulation 10 Hz
2. Edema reduction (in general) and prevention of venous thromboses
a. caused by stimulation of sympathetic fibers
b. (in lower legs an feet) caused by activation of the “muscle pump”
c. caused by reversible sustained partial depolarization of the smooth muscles of
the lymphatic vessels and the blood vessels, “plateau effect”
The following parameters should be preferred:
a. SimulFAMX with crossing of the threshold curve, frequency of modulation 10 Hz
b. SimulFAMX with crossing of the threshold curve, frequency of modulation 0.3 Hz
c. High intensity with higher fixed frequencies (max. 215 Hz)
3. - 5.
The therapeutically desired effects mentioned above concerning reduction of drugs
and their side effects, inhibition of cachexia and general enhancement of the quality of
life are present in all cases of parameter selection. They do not require special
parameters.
Selected Literature:
d‘ARSONVAL, A.:
Action physiologique des courants alternatitifs.
C. R. Soc. Biol. Paris 43, 453 (1891)
d‘ARSONVAL, A.:
Recherches d‘ électrothérapie. La voltaisation sinusoidale.
Arch. Physiol. norm. pathol. 24, 69 (1892)
d‘ARSONVAL, A.:
Effects physiologiques de la voltaisation sinusoidale.
Arch. Physiol. norm. pathol. 25, 387 – 391 (1893)
d‘ARSONVAL, A.:
Action physiologique des courants alternatitifs à grande fréquence.
Arch. Physiol. norm. pathol. 25, 401 – 408 (1893)
9
d‘ARSONVAL, A.:
Production des courants de haute fréquence et de grande intensité: leurs effects
physiologiques.
Comptes Rendus de séances et memoires
de la. Société de Biologie et de ses filiales. Paris 45, 122 - 124 (1893)
d‘ARSONVAL, A.:
Influence de la fréquence sur les effect physiologiques des courants alternatifs.
L’industrie électrique 2, 168 - 169 (1893)
d‘ARSONVAL, A.:
Action physiologique et thérapeutique des courants à haute fréquence.
Ann. Electrobiol. 1, 1 (1898)
BOWMAN, B. R.:
Electrical block of peripheral motor activity.
A dissertation submitted to the Faculty of Electrical Engineering
Edvard Kardelj University of Ljubljana, Yugoslavia
In partial fulfilment of the requirements for the degree
Doctor of Science (Electrical Engineering)
May 1981
Conducted at Rancho Los Amigos Rehabilitation Engineering Center,
Rancho Los Amigos Hospital, Downey, California
BRIGHTON, C. T., & P. F. TOWNSEND:
Increased cAMP production after short term capacitively coupled stimulation of bovine
growth plate chondrocytes.
Transactions of the 6th annual meeting of the Bioelectrical Repair and Growth Society
(BRAGS), vol.VI, p. 43, Oct. 19th – 22nd 1986
BROMM, B., & H. LULLIES:
Über den Mechanismus der Reizwirkung mittelfrequenter Wechselströme auf die
Nervenmembran.
Pflügers Arch. 289, 215 – 226 (1966)
CLARK, H. R.:
The cure of all cancers
San Diego, CA, USA: New Century Press 1993
CLARK, H. R.:
The cure for all diseases
San Diego, CA, USA: New Century Press 1995
CONE, C. D, Jr.:
Control of cell division by the electrical voltage of the surface membrane
Molecular Biophysics Laboratory, Langley Research Center, National Aeronautics and Space Administration,
Hampton, Virginia 23365
Presentation to
The 12th Annual Science Writers Seminar, San Antonio, Texas, March 20-25 1970 ,
American Cancer Society
10
CONE, C. D, Jr.:
Unified theory on the basic mechanism of normal mitotic control and oncogenesis.
J. theor. Biol. 30, 151 – 181 (1971)
CONE, C. D., Jr.:
The role of the surface electrical transmembrane potential in normal and malignant
mitogenesis.
Annals of the New York Academy of Sciences 238, 420 – 435 (1974)
CONE, C. D. Jr., & C. M. CONE:
Induction of mitosis in mature neurons in central nervous system by sustained depolarization.
Science 192, 155 - 157 (1976)
CONE, C. D. Jr. & M. TONGIER:
Contact inhibition of division: Involvement of the electrical transmembrane potential.
Cell Pysiology 82, 373 – 386 (1973)
DAFFORN, A. & D. E. KOSHLAND jr.:
Biochem. Biophys. Res. Commun. 52, 780, (1973)
DALZIEL, C. F.:
Electric shock.
Advances in Biomed. Engineering 3, 223 –248 (1973)
DALZIEL, C. F.:
Dangerous electric currents
AIEE Transactions 65, 579 – 584 (1946)
DALZIEL, C. F.:
The threshold of perception currents.
AIEE Transactions 73, 990 – 995 (1954)
DALZIEL, C. F., J. B. LAGEN & J. L. THURSTON:
Electric shock
AIEE Transactions 60, 1073 – 1078 (1941)
DALZIEL, C. F., E. OGDEN & C. E. ABBOTT:
Effect of frequency on let-go currents.
AIEE Transactions 62, 745 – 749 (1943)
DUDEK, J.:
Terapia energotonowa.
Ogólnopolski Przeglad Medyczny (OPM) 11/2002, 22
Katowice: Elamed® Wydawnictwo 2002
EHMEN,G.:
Diffusionsbeeinflussung im Knochengewebe durch Interferenzstromverfahren.
Diplomarbeit, Fachhochschule Wilhelmshaven, 1990
FRESENIUS, Hanna:
Krebsfürsorge (Letter to th editors)
11
Selecta 22, 329 – 331 (1980)
(Heft 4, 28. Jan. 1980)
FRESENIUS, Hanna:
Niederfrequenter Interferenzstrom gegen maligne Entartung
Ärztliche Praxis 37, 2529 (1985)
FRESENIUS, Hanna:
Was das Leben lebendig macht.
Erzählungen aus Steinau an der Straße
pp. 266 – 269: Experiences with interferential therapy in cancer patients.
Marquartstein, Bavaria, Germany: Th. Breit 1986
GAMMON, G. D., & I. STARR:
Studies on the relief of pain by counter-irritation.
J. clin. Invest. 20, 13 – 21 (1941)
GEDDES, L. A., L. E. BAKER, A. G. MOORE & T. W. COULTER:
Hazards in the use of low frequencies for the measurement of physiological events by
impedance.
Med. & biol. Engineering 7, 289 – 296 (1969)
GILDEMEISTER, M.:
Untersuchungen über die Wirkung von Mittelfrequenzströmen auf den Menschen.
Pflügers Arch. 247, 366 –404 (1944)
GREEN, R. T.:
The absolute threshold of electric shock.
Brit. J. Psychol. 53, 107 – 115 (1962)
HANSJÜRGENS, A., & H. U. MAY:
Elektrische Differentialtherapie1
Karlsruhe: Nemectron 1990
HAUSER-TILLMANN, Hildegard
Dr. med., M. D., Frauenärztin, Gynaecologist, in D -88677 Markdorf, Gutenbergstr. 1a):
Personal communication:
Arzt-Bericht vom 21. Oktober 1997 über eine von März bis September 1997 durchgeführte
erfolgreiche Hochton-Behandlung einer Patientin mit Gallensteinen und häufigen Koliken.
Clinical report, dated from October 21st 1997 concerning a successful high tone therapy
treatment of a female patient with gall-stones and frequent bilious colics over a period of
seven months (March – September 1997)
HÖNES, R. D.:
Der Einfluß von Interferenzstrom auf das Wachstumsverhalten von Zellkulturen.
Inauguraldissertation. Freiburg i. Br. 1983
HUMPERT, P. M., G. RUDOFSKY, M. MORCOS, A. BIERHAUS & P. P. NAWROTH:
Hochtontherapie zu Behandlung schmerzhafter Neuropathie bei Typ 2 Diabetikern verbessert
die mikrovaskuläre Endothelzellfunktion
1
EDiT®
12
High tone therapy for the treatment of painful neuropathy in type 2 diabetic patients improves
the microvascular endothelial function.
Poster and Abstract.
41. Jahrestagung der Deutschen Diabetes-Gesellschaft, Leipzig, 24. – 27. Mai 2006,
Diabetologie und Stoffwechsel 2006, DOI: 10.1055/s-2006-94
JAMAKOSMANOVIC, A., & W. LOEWENSTEIN:.
Intercellular communication and tissue growth III. Thyreoid cancer.
J. Cell Biology 38, 556 - 561 (1968)
JOOS, U., H. U. MAY & C. MITTERMAYER:
Stimulation of fibroblast proliferation by means of electrical current.
8th Int. Conf. Oral Surg., Berlin, June 25 – 30, 1983
KEILHOLZ, L., U. RANDOLL, R. SAUER & E. STEINHÄUSER:
Supportive interferential current therapy in the treatment of advanced head and neck tumors.
21. Deutscher Krebskongreß, Hamburg, 7.-11. März 1994
21th National Cancer Congress of the German Cancer Society
Supplement to Journal of Cancer Research and Clinical Oncology Vol. 120, 05.09.03 (1994)
KNEDLITSCHEK, G., K. F. WEIBEZAHN & H. DERTINGER:
Zelluläre Wirkungen des Interferenzstromes
21. Deutscher Krebskongreß, Hamburg, 7.-11. März 1994
21th National Cancer Congress of the German Cancer Society
Supplement to Journal of Cancer Research and Clinical Oncology Vol. 120, 05.09.02 (1994)
KOEPPEN, S.:
Über die Anwendung von Tonfrequenzströmen in der Medizin.
Verhandlungen der Deutschen Gesellschaft für innere Medizin, München, 47, 458 – 460
(1935)
KOMITOWSKI, D., & V. EHEMANN:
Der Einfluß von elektrischen Mittelfequenz-Wechselfeldern auf normale Fibroblasten,
normale und transformierte Hepatocyten sowie normale Nierenepithelzellen des
Rattenkänguruhs.
The influence of alternating middle-frequency electric fields upon fibroblasts, normal and
transformed hepatocytes and normal epithelial kidney cells of the rat kangaroo
Vorträge, gehalten über am Deutschen Krebsforschungszentrum in Heidelberg durchgeführte
Untersuchungen auf einem Symposion zum Thema „Tumoren und Ströme“ am 16. Mai 1990
in Karlsruhe
Lectures about the results of a study carried out in the German Cancer Research Center
Heidelberg, presented during a Symposion “Tumors and Currents” in Karlsruhe, Germany,
May 16th 1990
KORENSTEIN, R., D. SOMJEN, H. FISCHLER & I. BINDERMAN:
Capacitively pulsed electric stimulation of bone cells. Induction of cyclic-AMP changes and
DNA synthesis.
Biochimica et Biophysica Acta 803, 302 – 307 (1984), Elsevier Science Publishers
LAABS, W. A., E. MAY,
13
K. D. RICHTER, H. J. HÖHLING, J. ALTHOFF, P. QUINT & A. HANSJÜRGENS:
Knochenheilung und dynamischer Interferenzstrom (DIC) –
Erste vergleichende tierexperimentelle Studie an Schafen.
Teil I: Experimentelles Vorgehen und histologische Ergebnisse.
Teil II: Physikalische und chemische Ergebnisse.
Langenbecks Arch. Chir. 356, 219 – 229 u. 231 – 241 (1982)
LANGMAN, L., & H. S. BURR:
A technique to aid in the detection of malignancy of the female genitale tract.
Am. J. Obst. & Gynec 57, 274 – 281 (1949)
LOEWENSTEIN, W.:
Permeability of membrane junctions
In: Conferenc on biological membranes: recent Progress.
Annales New York Academy of Sciences 137, 441 – 472 (1966)
LOEWENSTEIN, W., & Y. KANNO:
Intercellular communication and the control of tissue growth:
Lack of communication between cancer cells
Nature 209, 1248 – 1249 (1966)
LOEWENSTEIN, W., & Y. KANNO:
Intercellular communication and tissue growth I. Cancerous growth.
J. Cell Biology 33, 225 – 234 (1967)
LOEWENSTEIN, W., & R. D. PENN:
Intercellular communication and tissue growth II. Tissue regeneration.
J. Cell Biology 33, 235 - 242 (1967)
JAMAKOSMANOVIC, A., & W. LOEWENSTEIN:.
Intercellular communication and tissue growth III. Thyreoid cancer.
J. Cell Biology 38, 556 - 561 (1968)
JOOS, U., H. U. MAY & Ch. MITTERMAYER:
Stimulation of Fibroblast proliferation by mean of electrical current
Presentation (Poster) to the 8th International Conference on Oral Surgery,
Berlin, 25-30 June 1983
KUKLINSKI, B.:
Interferential current therapy of tumors: Preliminary results
21. Deutscher Krebskongreß, Hamburg, 7.-11. März 1994
21th National Cancer Congress of the German Cancer Society
Supplement to Journal of Cancer Research and Clinical Oncology Vol. 120, 05.09.05 (1994)
LAKHOVSKY, Georges:
The secret of life.
London, 152, Landor road, Stockwell, S.W.9.: 1951 (First published in France 1935)
LYNES, B.:
The cancer cure that worked! Fifty years of suppression. The RIFE report.
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MAY, H. U.:
Simultaneous modulation of frequency and amplitude of middle frequency currents between
high tone and low ultrasound range – applied physiology for differentiated electrotherapy
concerning the distinction and specific proportional mixture of stimulatory and nonstimulatory (metabolic and/or blocking) effects.
In: Abstracts of the Joint Meeting of
The Physiological Society, Scandinavian Physiological Society and
Deutsche Physiologische Gesellschaft (81st Annual Meeting)
15-19 March 2002, Tübingen, Germany
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MAY, H. U.:
Extremely comfortable trancutaneous electrical stimulation of nerves – including motor and
sympathetic fibres – by simultaneous modulation of frequency and amplitude of middle
frequency currents.
In: Abstracts of the 83rd Annual Meeting
Deutsche Physiologische Gesellschaft
14-17 March 2004, Leipzig, Germany
Europ. J. Physiol. 447, Suppl.1, (P 35-11) S156 (2004)
MAY, H. U.:
High Tone Frequency Power Therapy with HiToP® in general and particularly in cases of
painful conditions of the musculo-skeletal system in special consideration of low back pain,
including a part of the results of a clinical study carried out and evaluated by E. RHADES & B. SCHNEIDER
Paper presented at the
4th Annual International Congress of Egyptian Society of Back Pain, Cairo, Egypt,
16 - 17 April 2004
MAY, H. U.:
High Tone Power Therapy
Scientific development to optimise the physical, physiological and therapeutic effects of
middle frequency currents
Paper presented at the
6th Annual International Congress of Egyptian Society of Back Pain, Cairo, Egypt,
19 – 20 April 2006
MAY, H. U., & A. HANSJÜRGENS:
Elektrische Differentialtherapie1
Electric Differential Therapy1
3 Posters (56 cm x 43 cm - in four languages), prepared for the
Medical center of the Olympic Village during the Olympic Games in Seoul 1988:
1) Electric Differential Therapy (in general),
2) Pain Management with EDiT
3) Treatment of edema usin EDiT
Karlsruhe, Nemectron 1988
MAY, H. U., F. NIPPEL & G. KONIECZNY:
Schmerzbehandlung als Voraussetzung für die Rehabilitation und die therapeutischen
Möglichkeiten der Interferenzstromtherapie. Erfolgsraten und Anwendungsquoten bei
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Zeitschrift für Physikalische Medizin 11, 63 - 67, 1982
15
MAY, H. U., F. J. NIPPEL, A. HANSJÜRGENS & K. MEYER-WAARDEN:
Acceleration of ossification by means of interferential current.
In: DIXON, A. D., & B. G. SARNAT (editors):
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Über die Wirkung von Wechselströmen verschiedener Frequenz auf die Hautsensibilität.
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Reizstromtherapie mit Interferenzströmen.
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Sofia: Medizina i Fiskultura 1971
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Clinical experimental and theoretical evidence for an additional circulatory system.
Stockholm, Sweden: Nordic Medical Publications 1983
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Wirkung mittelfrequenter Ströme auf Zellen in Suspension.
Diplomarbeit, Universität Karlsruhe, Fakultät für Bio- und Geowissenschaften, März 1988
NOSZVAI-NAGY, M.:
Wirkung des Mittelfrequenzstromes auf nicht-erregbare Zellen.
Dissertation. Universität und Kernforschungszentrum Karlsruhe, 1993/94
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Hooked? NET: The new approach to drug cure.
London: Faber & Faber 1986
PEKAR, R.:
16
Die perkutane Galvano-Therapie bei Tumoren.
Schwachstrombehandlung von zugänglichen Neoplasmen und ihre vitale Hybridisation in
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Wien, München, Bern: Wilhelm Maudrich 1988
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Eine Dokumentation zu Grundlage und Praxis der perkutanen Galvanotherapie
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Inauguraldissertation.
Institut für Anatomie und Zellbiologie der Universität Marburg 1988
PETROW, W., & H. W. KREYSEL:
Adjuvant therapy of malignant melanoma by interferen tial currents
21. Deutscher Krebskongreß, Hamburg, 7.-11. März 1994
21th National Cancer Congress of the German Cancer Society
Supplement to Journal of Cancer Research and Clinical Oncology Vol. 120, 05.09.04 (1994)
RACHMILEVIC, L. S., & I. A. JURASOVA
Primenenije peremennovo toka castotoi 6 kHz dlja elektrostimulazii myschz w
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REICHSTEIN, L., S. LABRENZ, D. ZIEGLER & S. MARTIN:
Effective treatment of symptomatic diabetic polyneuropathy by high-tone-frequency external
muscle stimulation.
Diabetologia 48, 824 – 828 (2005)
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History of the development of a successful treatment for cancer and other virus, bacteria and
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Rife Virus Microscope Institute, San Diego, Ca., 1953
SAVERY, F., A. A. ORTIZ & H. U. MAY:
Clinical application and effects of EDiT® and Endosan® treatment on diabetic neuropathy and
gangrene of toe
Advances in Therapy 7, 283 – 288 (1990)
SAVERY, F., A. A. ORTIZ, O. HAIKAL, K. FATHIE, G. S. CHOUDHURY, H. U. MAY &
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Electric differential treatment (EDiT®) and Endosan® treatment for ischemic diseases.
Advances in Therapy 8, 11 – 21 (1991)
SAVERY, F., F. SILVER, R. EDWARD, A. FANN, R. MANN, C. ROGERS, H. U. MAY &
R. SORGNARD:
Assessment of electric differential treatment (EDiT®) and Endosan® treatment for ovarian
cysts and concomitant symptoms
17
Advances in Therapy 8, 243 – 249 (1991)
SCHWARZ, F.:
(Physiolog. Inst. Universität Leipzig)
Über die Reizung sensibler Nerven des Menschen durch mittelfrequente Wechselströme.
Pflügers Arch. 247, 405 – 440 (1944)
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Lecture No. 6.
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WILK, M., W. W. FIBIGER & B. FRANZUK:
Zastowanie terapii energotonowej w rehabilitacji pacjentów po uszkodzeniach tkanek miekkich stawu kolanowego.
The application of high-tone power therapy in rehabilitation of patients with soft-tissue
damage to the knee joint.
Fizjoterapia Polska (Polish Journal of Physiotherapy) 2, 118 – 121 (2002)