KUVEMPU
UNIVERSITY
DEPARTMENT OF CHEMISTRY
SAHYDRI SCIENCE COLLEGE (Autonomous)
SHIMOGA - 577 203
APPROVED SYLLABUS FOR
INTEGRATED M.Sc.(HONS.) COURSE IN CHEMISTRY
X – SEMESTER
ANALYTICAL CHEMISTRY : 64 hours
UNIT–I
16 hours
SEPERATION TECHNIQUES
Solvent extraction: Definition, types, principle and efficiency of extraction, sequence of
extraction process, factors affecting extraction-pH, oxidation state, modifiers, synergistic,
masking and salting out agents, techniques-batch and continuous extraction, applications.
Supercritical fluid chromatography: Theory, properties of super critical fluids,
instrumentation, effect of pressure in elution column, mobile phases, detectors, applications.
Electrophoresis: Introduction, types and techniques of electrophoresis, factor affecting
migration of ions, continuous electrophoresis, thin layer electrophoresis, moving boundary
electrophoresis, zone electrophoresis, and Curtain electrophoresis, reverse osmosis electro
dialysis, capillary electrophoresis and applications.
Ultracentrifugation: Centrifugation, centrifugal force, sedimentation, centrifugal decantation,
centrifuges, selection of centrifuge tubes, preparative, density gradient and isopycinic
centrifugation, analytical sedimentation, sedimentation coefficient, sedimentation velocityApplication of the technique in biological separation; membrane separation - principle and
applications.
UNIT–II
16 hours
CHROMATOGRAPHIC TECHNIQUES
Gel permeation/filtration chromatography: Introduction, theory and principles of size
exclusion process-materials for size exclusion process- calibration techniques-weight average
and number average concept-application in polymer chemistry.
Affinity Chromatography:
Introduction, Classification, Selection of matrix, ligands
applications of affinity chromatography, immobilized bio chemicals.
Kinetic methods of analysis: Kinetics- the basics, Enzyme Catalysis properties of enzymes,
enzyme inhibitors and activators, some examples of enzyme analysis.
UNIT–III
16 hours
ELECTROANALYTICAL TECHNIQUES
Introduction, electrochemical cells, faradic and non-faradic current, mass transfer in cells,
galvanic and electrolytic cells, anodes and cathodes, liquid junction potential, schematic
representation of cells.
Polarography: Theory, principle and applications classical polarography, dropping mercury
electrode, polarogram, polarographic measurements, polarographic current, Ilkovic equation,
current and concentration relationship, half wave potential, oxygen interference- advantages and
limitations. Qualitative and quantitative analysis. Derivative polarography.
Amperometry, Coulometry at controlled potential and at constant current.
Cyclic voltametry - basic principles, instrumentation and applications.
Electrogravimetry - theory, electrode reactions, over-voltage, characteristics of a good deposit,
completeness of deposition, separation of metals at controlled cathode potential. Determination
of copper and nickel in Cu-Ni alloy.
UNIT–IV
16 hours
GREEN CHEMISTRY
Concept of green chemistry, Need for green chemistry, Goals, limitations
Principles – Introduction, Twelve principles,
Synthetic methods – Concept of atom economy, concept of selectivity, use of auxillary
substances, designing of synthetic methodologies, designing of products, use of green solvents,
catalytic reagents, designing of products, analytical methodologies, Energy requirements and
mode of supply of energy to reactions- use of microwaves, use of sonification with examples
Designing of green synthesis – Choice of starting materials, reagents, catalysts-biocatalysts,
polymer supported catalysts, choice of solvents
Green synthesis of adipic acid, catechol, paracetamol, acetaldehyde
KUVEMPU
UNIVERSITY
DEPARTMENT OF CHEMISTRY
SAHYDRI SCIENCE COLLEGE (Autonomous)
SHIMOGA - 577 203
APPROVED SYLLABUS FOR
INTEGRATED M.SC.(HONS.) COURSE IN CHEMISTRY
X – SEMESTER
INORGANIC CHEMISTRY : 64 hours
UNIT–I
16 hours
INDUSTRIAL APPLICATION OF ORGANOMETALIC CATALYSTS
Homogeneous and heterogeneous catalytic reaction-hydrogenation of olefins(Wilkinson’s
catalyst)-hydro formylation of olefins using cobalt or rhodium catalysts (oxoprocess)isomerization of olefins (Wacker process)-cycloologomerisation of acetylenes using Reppe’s
catalyst’ polymerization of olefins(Zeigler-Nata catalysts) Fischer-Tropsch process, polymer
supported catalyst. Graphite interchelation compounds, smectic clays pillard clays, Zeolites,
acrylonitrile-synthesis, alcohol dehydration gamma-alumina, reaction of olefins on zinc oxide,
carbon monoxide oxidation on palladium, anchord catalyst and catalytic converters.
UNIT–II
16 hours
ORGANOMETALLIC COMPOUND IN ORGANIC SYNTHESIS:
General introduction, green rules, use of iron and chromium carbonyls in the synthesis of
aromatic compounds, Heck reaction, Wacker process, Carbonylation reaction) Specific
applications in the synthesis of some natural products)
Use of zinc dialkyl, Grignard reagents, lithium alkyls, Gilman reagents (lithium dialkyl
cuprates), oragnoselenium, organoalluminium, oragnosilicon, organo germanium and organo
mercurials in organic synthesis.
UNIT–III
16 hours
Group 16 elements- The chalcogens (Oxygen, Sulphur. Selenium, Tellurium, Polonium)
General properties, oxidation states, extraction and uses of the elements-uses of di-oxygen,
extraction of sulphur, uses of sulphur, extraction and uses of selenium and tellurium.
Structure and allotropy of the elements-oxygen, sulphur, selenium, tellurium and poloinium,
oxidation states (+2, +4 and +6).
Difference between oxygen and other elements, general properties of oxides-normal oxides,
peroxides, sulphoxides, basic oxide and neutral oxides. Reaction between oxides-oxides of
sulphur, selenium, tellurium and polonium, dioxides (MO2), trioxides (MO3).
Oxo acids of sulphur- sulphurous acid series, sulphuric acid series, thionic acid series, peroxo
acid series. Oxo acids of selenium and tellurium, thionyl compounds, sulphonyl compounds.
UNIT–IV
16 hours
SOLID STATE AND MATERIAL CHEMISTRY:
General principles, defects, non-stoichimetric compounds and solid solutions. Atom and ion
diffusion, electrolytes, synthesis of materials-The formation of extended structures, chemical
decomposition; metal oxides, nitrides and fluorides, monoxides of the 3d metals, higher oxides
and complex oxides(spinals), oxides of glasses, chalcogenides, intercalation chemistry and metal
rich phases. Layered Ms2 compounds and intercalation. Cherrel phases.
Framework structures; structures based on Td-oxonium, stress based oxoniums.
Inorganic pigments:- coloured pigments, white and black allergic materials, molecular materials
and fullerides, material chemistry. fast-ion conducting solids, NASICON and alumina, fire
retardants, High-Tc, oxides. borides, halides, nano materials.
X SEM Inorganic practicals
1. Estimation of sulphate by EDTA method.
2. Estimation of sulphate using benzidinehydrochloride.
3. Micro volumetric estimation of chlorides.
4. Analysis of wood’s alloy.
5. Preparation and analysis of potassium tri(oxalate) ferrate (III) trihydrate.
6. Preparation and analysis of Hexamine cobalt (III) Chloride.
7. Preparation and IR spectral studies of pentaminenitrocobalt (III) chloride and the
corresponding nitrite complex.
8. Paper chromatography of Co+2, Ni+2, Cu+2 ions.
9. Preparation and analysis of dioxalatocopper (II)
10. Determination of composition of complex.
11. Determination of stability constant of a complex.
12. Spectroscopic ( Colorimetric) determination of Ti by peroxide method.
KUVEMPU
UNIVERSITY
DEPARTMENT OF CHEMISTRY
SAHYDRI SCIENCE COLLEGE (Autonomous)
SHIMOGA - 577 203
APPROVED SYLLABUS FOR
INTEGRATED M.SC.(HONS.) COURSE IN CHEMISTRY
X – SEMESTER
ORGANIC CHEMISTRY : 64 hours
UNIT-I
16 hours
Medicinal Chemistry
Chemotherapy, pharmacokinetics, pharmacodynamics, metabolites and anti metabolites prodrug
and soft drugs agonists and anti-agonists, concept of drug receptor, elementary treatment of drug
receptor interactions. Quantitative structure activity relationship (QSAR). Theories of drug
activity - accupency theory, rate theory, induced fit theory.
Mechanism of drug action and the synthesis of the following classes of drugs(Interconversion as
applicable).
Sulphonamides: Introduction, classification- sulphathiazole, sulphanilamide, sulphadiazine
Antimalarials: Introduction, classification, chloraquin and pamaquin
Analgesics: Introduction, classification, paraacetomol, aspirin, salol, cinophen, phenyl butazone,
antipyrine
Anti-inflammatory agents: Introduction, classification, indomethacin and ibuprofen
Antibiotics: Classification, penicillin-G, ampicillin, amoxycillin, chloramphenicol,
cephalosporins, tetracyclins-aureomycin, terramycin, streptomycine, new antibiotics.
UNIT-II
16 hours
POLYMERS
Polymers: Importance of polymers, basic concept, monomers repeat unit, degree of
polymerization, linear, branched, and network polymers, classification and nomenclature of
polymers, properties of polymers, brief explanation of molecular weight, glass transition
temperature-Tg, solubility and viscoelasticity. Methods of polymerization - addition and
condensation polymerization, ionic and free radical polymerization, polymerization with
complex catalysis (Ziegler-Natta catalyst), Co-polymerization and their mechanisms. Technique
of polymerization-bulk, emulsion etc.
Polymer degradative reactions - Thermal, oxidative and radiative process, synthesis of Buna-S,
butyl rubbers and poly anilines.
UNIT-III
16 hours
SYNTHETIC DYES and PETROCHEMICALS
Synthesis and methods of applications of following dyes (explanation of the principles
involved), Dyes with polar groups(Congo red), disperse dyes(1-Amino-4-hydroxy anthrquinone,
2-amino-5-nitrothiozole, 3-aminobenzisothiazole), fiber reactive dyes(triazine dyes), developed
dyes(indigo, tyrian purple, thiaozole dyes), photographic sensitizers(cyanines), fluorescent
brightening agents, color photography(additive and subtractive process), chemistry of colour
developers, instant colour processes.
Petrochemicals: Petroleum refining constituents of petroleum and their separation. Conversion
processes (cracking, reforming, alkylation) for precursors of petrochemicals. A brief discussion
of chemistry of manufacture of ethylene, propylene, butylene, acetylene, benzene and some of its
derivative and their conversions to some useful products, Fischer- Tropsch synthesis.
UNIT-IV
16 hours
PECTICIDES AND INSECTICIDES
Introduction, classification, naturally occurring insecticides - rotanones, pyrethrins, reocenes,
synthetic insecticides - properties and synthesis of DDT, BHC, chlordane, aldrine, dieldrin,
parathion, malathion.
Introduction to the use of following in the control of pests and insects - fumigants, nematicides,
acaricides, hormones(juvenile hormones), insect repellents molluscicides, rodenticides.
X SEMESTER PRACTICALS
MULTISTEP SYNTHESIS
01. Preparation of 2-phenyl indole by Fischer method
02. Preparation of indigo
03. Preparation of thiocol rubbber
04. Preparation of cinnamic acid
05. Preparation of salicylaldehyde by Reimer-Tiemann reaction
06. Preparation of phenylazo-β-naphthol
07. Preparation of 1-phenyl-3-methyl-pyrazolone
08. Preparation of styrene
09. Structural elucidation of organic compounds using different spectra
KUVEMPU
UNIVERSITY
DEPARTMENT OF CHEMISTRY
SAHYDRI SCIENCE COLLEGE (Autonomous)
SHIMOGA - 577 203
APPROVED SYLLABUS FOR
INTEGRATED M.SC.(HONS.) COURSE IN CHEMISTRY
X – SEMESTER
PHYSICAL CHEMISTRY : 64 hours
UNIT–I
16 hours
APPLICATIONS OF INFRARED AND RAMAN SPECTROSCOPHY
Vibration in simple molecules and their symmetry notation –group vibration and the limitationapplication of Raman spectroscopy-combined uses of IR and Raman spectroscopy in the
structural elucidation of simple molecules-effect of coordination on ligand vibration –uses of
group vibrations in structural elucidation of metal complexes of urea, thiourea, cyanide,
thiocyanate, nitrate, sulphate and dimethyl sulfoxide - vibrational spectra of metal carbonyls with
reference to the nature of bonding, geometry and number of C-O stretching vibrationsapplications of Raman spectroscopy.
Sampling techniques, factors influencing group frequencies-both internal and external
quantitative studies, hydrogen bonding conformational aspects in cyclic 1,2 diols and 1,3 diols,
APPLICATIONS OF NMR SPECTROSCOPY
H NMR spectroscopy-coupling constant- first order and second order splitting spin-spin
splitting- dependence of J on dihedral angle- vicinal and germinal coupling constants- karplus
equation- long range , coupling constants, influence of stereo chemical factor on chemical
shift of protons, an elementary treatment or NOE phenomenon -2D technique(COSY, NOESY.
And rosy), 13C NMR spectroscopy. Basic theory of FT-NMR- relaxation – broad band
decoupling off resonance and chemical shift correlations (CH, CH2. CH3, =CH2= and aromatic)
UNIT–II
16 hours
DIFFRACTION TECHNIQUES
Crystal symmetry- combination of symmetry elements – crystal classes- screw axis and glide
planes – space group - crystal axes, crystal system , unit cell , Bravais lattices, asymmetric
and crystallographic symmetry- basic concept and examples. The concept of reciprocal
lattice and its applications. X-ray diffraction, Bragg’s condition, Miller indices, Laue method
Debye –Scherrer, X-ray diffraction by single crystal- structure factor – determination of
space group by symmetric phase problem in structure analysis heavy atom method-Fourier
synthesis refinement of structure.
Neutron diffraction –magnetic scattering-applications and comparison with X-ray diffraction .
Electron Diffraction; Scattering intensity vs scattering angle , Wierl equation, measurement
technique, equation elucidation of structure of simple gas molecules, low energy electron
diffraction and structure of surfaces. basic principles and applications to simple molecules –
XeF6.
UNIT–III
16 hours
MOLECULAR QUANTUM CHEMISTRY
M.O.T, Types of molecular orbitals, linear combination of atomic orbitals (LCAO), bonding and
anti bonding orbitals, necessary conditions for atomic orbitals to combine to form molecular
orbitals, overlapping of S-S, S-P, P-P, atomic orbitals. p-d overlapping, non-bonding
combination of atomic orbitals.Molecular orbital energy diagram, bond order, illustration taking
example as H2 N2, O2, molecular orbital energy diagrams for Hetero-nuclear diatomic
molecules like NO, HF, HCl CO molecules, V.B. Theory postulates of quantum mechanics.
quantum mechanics. of Hydrogen molecule Ion(H2 +), and hydrogen molecule (H2),hybrid
atomic orbitals,Sp3 ,Sp2 ,Sp taking as an example CH4,NH3,BF3,BeF2.Huckel pi –electron
theory and its applications to ethylene, butadiene and benzene. Idea of self consistence fields.
UNIT–IV
16 hours
ELECTROCHEMISTRY
Theories of electrode potentials sedimentation potential, Dorn effect, streaming potential,
kinetics of electrode process, electrical double layer, Butler Volmer equation, Tafel equation,
generation of hydrogen.
CORROSION AND ELECTROPLATING
Theories of corrosion, thermodynamics of corrosion, measurement of corrosion rate by weight
loss,Tafel plots ,linear polarization impedance methods of study corrosion, type and prevention
of corrosion, metal finishing, electroplating of single metals like Zn, Cd, Cu, Au, Pt- alloy
plating, industrial application.
.