Huang, George
3/20/11
CURRICULUM VITAE
George T.-J. Huang, D.D.S., M.S.D., D.Sc.
TITLE:
Associate Professor
INSTITUTION:
Boston University
Henry Goldman School of Dental Medicine
Department of Endodontics
100 E. Newton St., G-705
Boston University, MA 02118
E-mail: gtjhuang@bu.edu
HOME ADDRESS:
89 Needham St, #2412
Newton, MA 02461
E-mail: gtjhuang@gmail.com
This is to state that the CV document prepared and presented herein is truthful
George T.-J. Huang__________________________
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Huang, George
EDUCATION:
1992 Doctor of Science (D.Sc.) in Oral Biology, Dept. of Oral Biology, Boston University
1989 Master of Science in Dentistry (M.S.D.), Dept. of Endodontics, Boston University
1988 Certificate in Endodontics, Dept. of Endodontics, Boston University
1983 Doctor of Dental Surgery (D.D.S.), School of Dentistry, Taipei Medical College
PROFESSIONAL EXPERIENCE:
2009Associate Professor, Chair and Herbert Schilder Professor in Endodontics
Director, Postgraduate Program in Endodontics
Boston University Henry M. Goldman School of Dental Medicine
2009-2009
Director (Head), Associate Professor, Columbia University, College of Dental
Medicine, Division of Endodontics
2009Visiting Professor, Taipei Medical University, Taiwan, ROC
2007-2008
Visiting Professor, Kaohsiung Medical University, Taiwan, ROC
2005-2008
Associate Professor, University of Maryland, College of Dental Surgery, Dental
School, Division of Endodontics
2006Researcher at NIH/NIAMS Intramural Cartilage Biology and Orthopaedics Branch,
Tissue Engineering Section (Dr. Rocky Tuan’s group), working on mesenhymal stem
cells and tissue engineering.
2005-2006
Researcher at NIH/NIDCR Intramural Oral Infection and Immunity Branch (Dr.
Sharon Wahl’s group), working on Laser Capture Microscopy and Affymetrix
GeneChip.
1999-2004
Director, Postgraduate Program, Section of Endodontics
University of California, Los Angeles
1999-2000
Acting Chair, Section of Endodontics
University of California, Los Angeles
1997Diplomate, American Board of Endodontics
1996-2003
Research Director, Section of Endodontics
University of California, Los Angeles
1995-2004
Assistant Professor, Section of Endodontics
University of California, Los Angeles
1994-1995
Lecturer in Endodontics, Section of Endodontics
University of California, Los Angeles
1993-1995
Postgraduate Research Immunologist, School of Medicine
University of California, San Diego
1992-1993
Postdoctoral Fellow, School of Medicine
University of California, San Diego
1990-1992
Clinical Instructor, Dept. of Endodontics (Part-time), Boston University
1985-1986
Private Practice in General Dentistry, Taipei, Taiwan, Republic of China (ROC)
1983-1985
Military Service, Taiwan, Republic of China
PROFESSIONAL LICENSURE
2009-2009
Restricted Dental License (New York)
2005-2008
Teacher’s License (Maryland State)
1990-Present California State Dental License (active)
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Huang, George
1989-Present
1987-Present
1985-1986
Florida State Dental License (active)
Taiwan, Republic of China, Dental License (inactive)
Taiwan, Republic of China, Dental License (active)
HONORS AND AWARDS
2004
Won first award of research proposals submitted by faculty researchers
Funding agent: American Association of Endodontists Foundation (peer-reviewed)
1998
Faculty Career Development Award, University of California, Los Angeles
1997Diplomate, American Board of Endodontics
1992-1994
National Research Service Award (NIH/NIDDK)
1989-1992
Training Grant Recipient for D.Sc. Degree (NIH/NIDR)
MEMBERSHIPS:
American/International Association of Dental Research (1990-present)
American Association of Endodontists (1986-present)
UCLA Dental Research Institute (1996-2004)
ADMINISTRATIVE SERVICE
A. COMMITTEE SERVICE AT UCLA, Columbia U and Boston U
2009Executive committee (CU, BU)
2009Clinical Finance Committee (BU)
Postdoctoral Curriculum Committee (BU)
Merit increase task force ad hoc committee (BU)
2000-2004
School-Wide Space Planning Committee (UCLA)
1999-2004
Postgraduate Certificate and Residency Program Committee (UCLA)
2000-2001
Appointments, Promotions, and Appraisals Committee (observer) (UCLA)
1999-2000
Search Committee for Endodontic Chair (UCLA)
1997-1999
Research Advisory Committee (UCLA)
1997-2000
Oral Biology Fellowships Committee (UCLA)
1996-1997
Health and Safety Committee (UCLA)
1999-2003
Admission Committee interviewer (UCLA)
B. ADMINISTRATIVE RESPONSIBILITIES AT UCLA, CU and BU
2009-present Chair/Director, Department of Endodontic, Boston University
2009
Director, Division of Endodontics, Columbia University
2003-2004
Accreditation preparation as Director (Postgraduate Program),
Section of Endodontics,
University of California, Los Angeles
1999-2004
Director, Postgraduate Program, Section of Endodontics
University of California, Los Angeles
1999-2000
Acting Chair, Section of Endodontics
University of California, Los Angeles
1996-2003
Research Director, Section of Endodontics
University of California, Los Angeles
C. INTERVIEWER FOR UCLA DDS CANDIDATES
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Huang, George
1999-2001
2003-2004
RESEARCH
A. RESEARCH FUNDING
Extramural
NIH
1. a. Project title: Regeneration of clinically relevant orofacial tissues in pre-clinical models
b. Principal Investigator: Jeremy Mao
c. Collaborators: George Huang et al
d. Funding agent: PHS/NIDCR (National Institute of Dental Craniofacial Research)
e. Type: GO grant 5RC2DE020767
f. Proposed period: 8-1-09 to 6-30-11
g. Total cost: $1,037,466
2. a. Project title: Regeneration of Pulp-Dentin Development in Immature Permanent Teeth
with Pulp Necrosis
b. Principal Investigator: Ken Hargreaves
c. Consultants: George Huang et al
d. Funding agent: PHS/NIDCR (National Institute of Dental Craniofacial Research)
e. Type: R34
f. Proposed period: 8-1-10 to 6-30-13
g. Direct cost: $150,000
3. a. Project title: Stem cell based therapy for regenerative endodontics
b. Principal Investigator: George T.-J. Huang
c. Collaborators : Songtao Shi et al
d. Funding agent: PHS/NIDCR (National Institute of Dental Craniofacial Research)
e. Type: RO1 3R01DE019156-02S1
f. Proposed period: 8-1-09 to 6-30-11
g. Direct cost: $31,427
4. a. Project title: Stem cell based therapy for regenerative endodontics
b. Principal Investigator: George T.-J. Huang
c. Collaborators : Songtao Shi et al
d. Funding agent: PHS/NIDCR (National Institute of Dental Craniofacial Research)
e. Type: RO1 1R01DE019156-01
f. Proposed period: 8-1-08 to 6-30-13
g. Direct cost: $1,150,000
h. Indirect cost:$700,000
5. a. Project title: Antimicrobial Gene Therapy
b. Principal Investigator: George T.-J. Huang
c. Funding agent: PHS/NIDCR (National Institute of Dental Craniofacial Research)
d. Type: R21 1R21DE014585-01
e. Proposed period: 5-1-02 to 4-31-04 (no cost extension to 4-31-05)
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Huang, George
f. Direct cost: $200,000
g. Indirect cost: $ 87,497
h. Total cost: $ 287,497
6. a. Project title: Molecular control of ICAM-1 expression in oral cancer
b. Principal Investigator: George T.-J. Huang
c. Funding agent: PHS/NIDR (National Institute of Dental Research)
d. Award #: RO3 (5R03DE012141-02)
e Period: 1-1-97 to 12-30-98 (no cost extension to 12-30-99)
f. Direct cost: $50,000
g. Indirect cost: $24,500
h. Total cost: $ 74,500
7. a. Project title: A novel herpesviral vector for oral gene delivery
b. Principal Investigator: Hongyu Deng
c. Collaborators: George T.-J. Huang et al
d. Funding agent: PHS/NIDCR (National Institute of Dental Craniofacial Research)
e. Type: K22
f. Proposed period: 7-1-04 to 6-30-09
g. Direct cost: $600,000
Foundations (peer reviewed)
1. a. Project title: Candida Species as an Endodontic Pathogen in HIV+/AIDS
Population
b. Principal Investigator: Nadia Chugal
c. Co-Investigators: George T.-J. Huang et al
d. Funding agent: The Campbell Foundation (peer-reviewed)
e. Award type: Research Grant
f. Period: 7-1-00 to 6-30-03
g. Direct cost: $65,000
2. a. Project title: Antimicrobial Gene Therapy
b. Principal Investigator: George T.-J. Huang
c. Co-Investigator: Dr. Tomas Ganz
d. Funding agent: The Stein Oppenheimer Endowment Award (peer-reviewed)
e. Type: Research Seed Grant
f. Period: 2-1-01 to 1-30-03
g. Direct cost: $20,000
AAE Foundation (peer reviewed)
Faculty Research grant
1. a. Project title: Stem cell based periodontal ligament regeneration for avulsed teeth
b. Principal Investigator: George T.-J. Huang
d. Funding agent: American Association of Endodontists Foundation
e. Type: Research grant
f. Direct cost: $20,000
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Huang, George
g. Proposed period: 1-1-09 to 12-30-09 extended to 6/30/11
2. a. Project title: Pulp tissue engineering
b. Principal Investigator: George T.-J. Huang
c. Funding agent: American Association of Endodontists Foundation (peer-reviewed, won
first award of proposals submitted by researchers)
d. Type: Research Grant
e. Direct cost: $43,000
f. Proposed period: 1-1-06 to 6-30-09
3. a. Project title: Regulation of proinflammatory cytokines by substance P in dental pulps
b. Principal Investigator: George T.-J. Huang
c. Funding agent: American Association of Endodontists Foundation (peer-reviewed)
d. Type: Research Grant
e. Direct cost: $16,000
f. Proposed period: 7-1-02 to 6-30-03 (no cost extension to 6-30-04)
4. a. Project title: Kinetics of Interleukin-8 Expression in Diseased Dental Pulps
b. Principal Investigator: George T.-J. Huang
c. Funding agent: American Association of Endodontists Foundation (peer-reviewed)
d. Award type: Research Grant
e. Period: 7-1-98 to 6-30-99 (no cost extension to 6-30-00)
f. Direct cost: $12,000
Resident research grants mentored
1. a. Project title: De novo regeneration of periodontal ligament using stem cell sheet
technique
b. Principal Investigator: Philippe Gauthier
c. Co-Investigator/Mentor: George T.-J. Huang
d. Funding agent: American Association of Endodontists Foundation
d. Type: Research Grant
e. Direct cost: $16,470 (PI won best proposal as resident)
f. Proposed period: 6-1-11 to 6-30-13
2. a. Project title: Characterization of subpopulations of dental pulp stem cells
b. Principal Investigator: Mey Alhabib
c. Co-Investigator/Mentor: George T.-J. Huang
d. Funding agent: American Association of Endodontists Foundation
d. Type: Research Grant
e. Direct cost: $32,500 (highest amount as resident grant as of 2010)
f. Proposed period: 6-1-10 to 6-30-12
3. a. Project title: Identification and isolation of stem cells in periapical granulation
tissue
b. Principal Investigator: Toshinori Tanaka
c. Co-Investigator/Mentor: George T.-J. Huang
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Huang, George
d. Funding agent: American Association of Endodontists Foundation
d. Type: Research Grant
e. Direct cost: $12,500
f. Proposed period: 6-1-09 to 6-30-10
4. a. Project title: In vitro maintenance of human dental pulp stem cell self-renewal
capability
b. Principal Investigator: Thai Pham
c. Co-Investigator/Mentor: George T.-J. Huang
d. Funding agent: American Association of Endodontists Foundation
d. Type: Research Grant
e. Direct cost: $15,000
f. Proposed period: 6-1-09 to 6-30-10
5. a. Project title: Age Influence on human Dental Pulp Stem Cell (hDPSC) properties
b. Principal Investigator: Jae Oh
c. Co-Investigator/Mentor: George T.-J. Huang
d. Funding agent: American Association of Endodontists Foundation
d. Type: Research Grant
e. Direct cost: $20,000
f. Proposed period: 6-1-09 to 6-30-10
6. a. Project title: Tissue regeneration potential of dental pulp stem cells from inflamed
a. Project title: Effect of inflammation on pulp stem cell potency
b. Principal Investigator: Dominick Alongi
c. Co-Investigator/Mentor: George T.-J. Huang
d. Funding agent: American Association of Endodontists Foundation
d. Type: Research Grant
e. Direct cost: $24,000 (highest resident grant as of 2007)
f. Proposed period: 6-1-07 to 6-30-08
5.
a. Project title: Cytokines and HLA class II expression in epithelial cell of periapical
granulomas and cysts
b. Principal Investigator: David C. Han
c. Co-Investigator/Mentor: George T.-J. Huang
d. Funding agent: American Association of Endodontists Foundation (peer-reviewed)
e. Award type: Research Grant
f. Period: 7-1-01 to 6-30-02
g. Direct cost: $8,256
6. a. Project title: Expression of Interleukin-8 in Normal and Diseased Dental Pulps
b. Principal Investigator: Anthony P. Potente
c. Mentor/Co-Investigator: George T.-J. Huang
d. Funding agent: G5188/American Association of Endodontists Foundation (peer-reviewed)
e. Award #: 013437; Resident Grant (Anthony P. Potente)
f. Period: 7-1-97 to 6-30-98 (no cost extension to 6-30-99)
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Huang, George
g. Direct cost: $2,008
7. a. Project title: Effect of interleukin-6 deficiency on the formation of periapical
lesions in mice
b. Principal Investigator: Margaret Wingard
c. Mentor/Co-Investigator: George T.-J. Huang
d. Funding agent: G5188/American Association of Endodontists Foundation (peer-reviewed)
e. Award #/type: 013432; Resident Grant (Margaret Wingard)
f. Period: 7-1-97 to 6-30-98 (no cost extension to 6-30-99)
g. Direct cost: $3,620
Industry
1. a. Project title: periodontal ligament regeneration with stem cells
b. Principal Investigator: George T.-J. Huang
c. Funding agent: Dentsply
d. Type: Research Grant
e. Direct cost: pending
f. Indirect cost:
g. Proposed period:
Intramural (UCLA)
1. a. Project title: Down-modulation of local immunity by P. gingivalis
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA
d. Type: Academic Senate Grant
e. Period: 7-1-02 to 6-30-03
f. Direct cost: $4,200
2. a. Project title: A Model for Anti-microbial Gene Therapy
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA
d. Type: Academic Senate Grant
e. Period: 7-1-01 to 6-30-02
f. Direct cost: $4,500
3. a. Project title: Molecular Basis of Epithelial Cells in Immune System
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA
d. Type: Academic Senate Grant
e. Period: 7-1-00 to 6-30-01
f. Direct cost: $1,900
4. a. Project title: Mechanism of ICAM-1 down-regulation by P. gingivalis
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA
d. Type: Academic Senate Grant
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Huang, George
e. Period: 7-1-99 to 6-30-00
f. Direct cost: $ 8,000
5. a. Project title: Host immune responses to oral neoplastic and infectious diseases
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA Academic Development (Account# 441930-19900Huang)
d. Type: Faculty Career Development Award (UCLA)
e. Period: 6-1-98 to 5-30-99
f. Direct cost: $3,000
6. a. Project title: Mechanism of IL-8 down-regulation by P. gingivalis
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA (Account# 4-591960-19914-07)
d. Type: Academic Senate Grant
e. Period: 7-1-98 to 6-30-99
f. Direct cost: $ 5,200
7. a. Project title: Regulation of ICAM-1 and IL-8 by human gingival keratinocytes
following bacteria invasion
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA (Account# 4-591960-19914-07)
d. Type: Academic Senate Grant
e. Period: 7-1-97 to 6-30-98
f. Direct cost: $ 3,000
8. a. Project title: Molecular control of ICAM-1 expression in oral cancer
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA (Account# 4-591960-19900-07)
d. Type: Academic Senate Grant
e. Period: 7-1-96 to 6-30-97
f. Direct cost: $ 3,900
9. a. Project title: Anti-microbial Gene Therapy
b. Principal Investigator: George T.-J. Huang
c. Co-investigators: Tomas Ganz, Ichiro Nishimura
d. Funding agent: UCLA/Dentistry
e. Type: opportunity research award
f. Period: 7-1-01 to 6-30-02
g. Direct cost: $5,000
10. a. Project title: Anti-microbial Gene Therapy
b. Principal Investigator: George T.-J. Huang
c. Co-investigators: Tomas Ganz,
d. Funding agent: UCLA Dental Research Institute
e. Type: Research seed grant
f. Period: 7-1-00 to 6-30-02
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Huang, George
g. Direct cost: $10,000
11. a. Project title: Molecular Basis of Epithelial Cells in Immune System
b. Principal Investigator: George T.-J. Huang
c. Co-investigators: Tomas Ganz, Susan Haake
d. Funding agent: UCLA/Dentistry
e. Type: Overhead/opportunity research award
f. Period: 7-1-00 to 6-30-01
g. Direct cost: $10,000
12. a. Project title: Mechanism of IL-8 downregulation by P. gingivalis
b. Principal Investigator: George T.-J. Huang
c. Co-investigators: Susan Haake, Howard Kuramitsu
d. Funding agent: UCLA/Dentistry
e. Type: Overhead/opportunity research award
f. Period: 7-1-99 to 6-30-00
g. Direct cost: $10,000
13. a. Project title: IL-8 regulation in infected gingival epithelial cells
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA/Dentistry
d. Type: Overhead/opportunity research award
e. Period: 9-1-97 to 6-30-98
f. Direct cost: $7,000
14. a. Project title: Expression of cytokines and adhesion molecules by oral
keratinocytes following bacteria invasion
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA/Dentistry
d. Type: Overhead/opportunity research award
e. Period: 7-1-96 to 6-30-97
f. Direct cost: $9,000
15. a. Project title: Expression of cytokines and adhesion molecules by oral
keratinocytes in response to infection
b. Principal Investigator: George T.-J. Huang
c. Funding agent: UCLA/Dentistry
d. Type: Start-up fund (Overhead/opportunity research award)
e. Period: 10-1-95 to 6-30-96
f. Direct cost: $15,000
B. PUBLICATIONS:
Thesis
1. Molecular Cloning and Characterization of Hamster Multiple ALG7 Transcripts. Doctor
of Science (D.Sc.) in Oral Biology, Boston University, 1992
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Huang, George
2. The Effects of Moisture Content and Endodontics Treatment on Some Mechanical
Properties of Human Dentin. Master of Science in Dentistry (M.Sc.D.) in Endodontics,
Boston University, 1989.
Peer Reviewed Articles
*Corresponding author
1. V. T-K Yamagishi*, C. D. Torneck, S. Friedman, G. T-J Huang, M. Glogauer. Blockade
of tlr2 inhibits p. Gingivalis suppression of mineralized matrix formation by human dental
pulp stem cells. J. Endodont, in press
2. G T-J Huang, Apical cyst theory: a missing link. Dental Hypothesis, 1(2):76-84, 2010 Oct
5.
3. X. Wang, B Thibodeau, M Trope, LM. Lin, and G. T.-J. Huang* Histological
Characterization of Regenerated Tissues in Canal Space after Revitalization/
Revascularization Procedure of Immature Dog Teeth with Apical Periodontitis. J Endodont
Epub 2009. PMID: 20003936 (Journal cover page).
4. Dominick J. Alongi, Takayoshi Yamaza, Yingjie Song, Elaine Romberg, Rocky S. Tuan,
Songtao Shi and George T.-J. Huang*, Clonogenic Stem/Progenitor Cells from
Inflamed Human Dental Pulp Remtain Tissue Regenerative Potential. Regen Med, onlineEpub, May 2010. Nih PMID:20465527
5. X. Yan, H. Qin, C. Qu, RS Tuan, S. Shi, and G. T.-J. Huang* iPS cells reprogrammed from
mesenchymal-like stem/progenitor cells of dental tissue origin. Stem Cells Devel, On-line
EPub Oct 1, 2009. PMID: 19795982.(Quoted by Mesenchymal Stem Cells News 2009) nih
(#2 most read article of Stem Cells Devel as of Dec, 2010) (invited to compete for 12th
Royan international research award.)
6. F. Djouad, W. M. Jackson, B.E. Bobick, S. Janjanin3, Y. Song, G. T.-J Huang, R.S. Tuan*
Activin A expression regulates multipotency of mesenchymal progenitor cells. Stem Cell Res
Ther. On-line May, 2010 , nih
7. G.T.-J. Huang*, T. Yamaza, L.D. Shea, F. Djouad, N. Kuhn, R.S. Tuan and S. Shi.
Stem/progenitor Cell-Mediated De Novo Regeneration of Dental Pulp with Newly Deposited
Continuous Layer of Dentin in an In Vivo Model. Tissue Engineering, Sept, 2009 Epub.
PMID: 19737072 nih (#1 most read article of Tissue Eng as of Dec, 2010)
8. Feng F, Akiyama K, Liu Y, Yamaza T, Wang TM, Chen JH, Wang BB, Huang GT, Wang S,
Shi S. Utility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases. Oral
Dis. 2010 Jan;16(1):20-8. PMID: 20355278 (Best paper of Oral Dis in 2010)
9. Wataru Sonoyama,; Yi Liu,; Takayoshi Yamaza, Rocky S. Tuan, Songlin Wang, Songtao
Shi, and George T.-J. Huang*, Characterization of Apical Papilla and its Residing Stem
Cells from Human Immature Permanent Teeth –A Pilot Study. J Endodont. 34(20, 166-71,
2008. (Cover page) PMID: 18215674
10. Huang GTJ, Lee HW, Lee HS, Lee GH, Huh SY, Choi GW, Park SH*. Localization of
substance P-induced upregulated interleukin-8 expression in human dental pulp explants. Int
Endod J. 2007 Nov 12; [Epub ahead of print] PMID: 18005045
11. L.-H. Chueh and G. T.-J. Huang* Immature teeth with periradicular periodontitis or abscess
undergoing apexogenesis – a paradigm shift. J Endodont. 2006 Dec;32(12):1205-13. Epub
2006 Oct 13Dec, 2006 (Cover page) PMID: 17174685. (Selected by the editor for media
outreach; interviewed by Alan Mozes at HEALTHDAY, NY Times syndicate, news article
published in various health news internationally; interviewed by LA Times Today and
Scientific American)
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Huang, George
http://yourtotalhealth.ivillage.com/stem-cell-technique-could-help-kids-avoid-root-canal.html
http://www.ndri.com/article/root_canal_therapy__endodontic_treatment_an_alternative_techniqu
e_for_restoring_your_children_strong_tooth_-178.html
http://www.washingtonpost.com/wp-dyn/content/article/2006/12/21/AR2006122101043.html
http://www.dentaltribune.com/dt/common/includes/pdf_view_public.php?query=usendo/0107/et
_us_0107_0203.pdf
12. C. Yin, H.N. Dang, F. Gazor, and G. T.-J. Huang*. Mouse salivary gland and human defensin as a study model for antimicrobial gene therapy--technical considerations. Int. J.
Antimicrob. Agent,. 2006. Oct;28(4):352-60. Epub 2006 Sep 11. PMID: 16963233
13. G. T.-J. Huang*, K. Shagramanova and S. W. Chan, Formation of Odontoblast-Like Cells
from Cultured Pulp Cells on Dentin In Vitro. J Endodont 2006, Nov. 32(11): 1066-73.
PMID: 17055908
14. Huang, G. T.-J.*, Sonoyama, W., Chen, J. and Park, S. H, In vitro characterization of
human dental pulp cells –different isolation methods and culturing environments. Cell Tissue
Res 324:225-36, 2006; Epub Jan. 2006. PMID: 16440193
15. C. Yin, Hoa N. Dang, H-B Zhang, F. Gazor, D. Kim, O. E. Sorensen, and G.T.-J. Huang*.
Capacity of Human β-Defensin Expression in Gene-Transduced and Cytokine-Induced Cells.
Biochem. Biophys. Res. Comm. 2006 Jan 6;339(1):344-54. Epub 2005 Nov 15. PMID:
16298338
16. G. T.-J Huang* H.N. Dang, H.-B. Zhang, and S. K. Haake. Differential Regulation of
Cytokine Genes in Gingival Epithelial Cells Challenged by F. nucleatum and/or P.
gingivalis. Microb. Pathog. 37(6):303-312, 2004. (Selected as the top 25 hottest articles
(12th place) on ScienceDirect.com within the journal) PMID: 15619426
17. G.T.-J. Huang*, H.-B. Zhang, Chunyi Yin and S.H. Park. Human -defensin-2 gene
transduction of dental pulp cells: A model for pulp antimicrobial gene therapy. Int. J. Oral
Biol. Mar, 29(1) 7-12, 2004.
18. Park, S.H., Hsiao, G. and Huang, G.T.-J.* Role of Neuropeptides in the Regulation of
Interleukin-8 and Monocyte Chemoattractant Protein-1 Expression in Human Dental Pulp.
Int. Endodontic J. 37(3):185-192, 2004. PMID: 15009408
19. Han, D.C., G.T.-J. Huang, L.M. Lin, N. Warner, Gim, J.S. and A. Jewett.* Expression of
MHC Class II, CD70, CD80, CD86 and pro-inflammatory cytokines is differentially
regulated in oral epithelial cells following bacterial challenge. Oral Microbiol. Immunol.,
18:350-358, 2003. PMID: 14622340
20. Patel, T., Park, S.H., Lin, L., Chiappelli, F. and Huang, G.T.-J.* Substance P Induces
Interleukin-8 Production from Human Dental Pulp Cells. Oral Surg. Oral Med. Oral Path.
Oral Radiol. Endod. 96(4): 478-485, 2003.
21. Huang, G. T.-J.*, Zhang, H.-B., Liu, L., Kim, D., and Ganz, T. A model for antimicrobial
gene therapy--Demonstration of human -defensin-2 antimicrobial activities in vivo. Human
Gene Therapy, 13:2017-2025, Nov 20, 2002. PMID: 12489997
22. Huang, G. T.-J.,* Do, M., Wingard, M., Park, J. S., and Chugal, N., Effect of interleukin-6
deficiency on the formation of periapical lesion after pulp exposure in mice. Oral Surg. Oral
Med. Oral Path. Oral Radiol. Endod., 92(1):83-8, 2001. PMID: 11458250
23. Huang, G.T.-J.,* Kim, D., Lee, J. K.-H., Kuramitsu, H. K. and Kinder Haake, S.
Interleukin-8 and Intercellular Adhesion Molecule-1 Regulation in Oral Epithelial Cells by
Selected Periodontal Bacteria: Multiple Effects of Porphyromonas gingivalis via
Antagonistic Mechanisms. Infect Immun. 69(3):1364-1372, 2001. PMID: 11179300
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Huang, George
24. Huang, G.T.-J.* Zhang, X. and Park, N.-H., Increased ICAM-1 expression in transformed
human oral epithelial cells: Molecular mechanism and functional role in peripheral blood
mononuclear cell adhesion and lymphokine-activated-killer cell cytotoxicity. Int. J.
Oncology, 17:479-486, 2000. PMID: 10938387
25. Han, Y.*, Shi, W., Huang, G.T.-J, Haake, S.K., Park, N.-H., Kuramitsu, H., Genco, R.J.,
Interactions between periodontal bacteria and human oral epithelial cells: Fusobacterium
nucleatum adheres to and invades epithelial cells. Infect. Immun., 68(6):3140-3146, 2000.
PMID: 10816455
26. Huang, G. T.-J.*, Chugal, N., Potente, A. P., and Zhang, X., Constitutive Expression of
Interleukin-8 and Intercellular Adhesion Molecule-1 in Human Dental Pulps. Int. J. Oral
Biol. 24(4):163-168, 1999.
27. Huang, G. T.-J.*, Potente, A. P., Kim, J.-W., Chugal, N., and Zhang, X., Increased
interleukin-8 expression in inflamed human dental pulps. Oral Surg. Oral Med. Oral Path.
Oral Radiol. Endod., 88:214-20, 1999. PMID: 10468466
28. Huang, G. T.-J.*, and Zhang, X., Immunohistochemical Analysis of Interleukin-8 and
Intercellular Adhesion Molecule-1 in Human Gingival Epithelium. Int. J. Oral Biol., 24:716, 1999.
29. Huang, G.T.-J.*, Kinder-Haake, S., Kim, J.-W and Park, N.-H., Differential expression of
interleukin-8 and intercellular adhesion molecule-1 by human gingival epithelial cells in
response to Actinobacillus actinomycetemcomitans or Porphyromonas gingivalis infection.
Oral Micro. Immun., 13:301-309, 1998. PMID: 9807122
30. Huang, G.T.-J.*, Kinder-Haake, S. and Park, N.-H., Gingival epithelial cells increase
interleukin-8 secretion in response to Actinobacillus actinomycetemcomitans challenge. J.
Periodont., 69:1105-1110, 1998. PMID: 9802708
31. Huang, G.T.-J., Lenon, K. and Kukuruzinska, M.A.*, Characterization of multiple
transcripts of the hamster dolichol-P-dependent N-acetylglucosamine-1-P transferase
suggests functionally complex expression. Mol. Cell. Biochem., 181:97-106, 1998. PMID:
9562246
32. Huang, G.T.-J., Eckmann, L., Savidge, T.C. and Kagnoff, M.F.*, Infection of human
intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion
molecule-1 (ICAM-1) expression and neutrophil adhesion. J. Clinical Investigation,
98(2):572-583, 1996. PMID: 8755670
33. Eckmann, L., Huang, G.T.-J., Smith, J.R., Morzycka-Wroblewska E. and Kagnoff, M.F.*,
Increased transcription and coordinate stabilization of mRNAs for secreted immunoglobulin
alpha heavy chain and kappa light chain following stimulation of immunoglobulin A
expressing B cells. J. Biological Chemistry, 269(52):33102-9, 1994 (The first two authors
contributed equally to this work) PMID: 7806538
34. Mota, O.M., Huang, G.T.-J., Kukuruzinska, M.A.*, Developmental regulation and tissuespecific expression of hamster dolichol-P-dependent N-acetylglucosamine-1-P transferase
(GPT). Biochem. Biophys. Res. Comm., 204(1)284-91, 1994. PMID: 7945372
35. Huang, G.T.-J., Schilder, H.* and Nathanson, D., Effects of moisture content and
endodontic treatment on some mechanical properties of human dentin. J. Endodont.,
18(5):209-15, 1992. PMID: 1402574
Review Articles (peer reviewed)
13
Huang, George
36. Huang GT. Dental pulp and dentin tissue engineering and regeneration: advancement and
challenge. (invited), Front Biosci (Elite Ed). 2011 Jan 1;3:788-800. PMID:21196351
37. G. T.-J. Huang* Induced pluripotent stem (iPS) cells – a new foundation in medicine. J Exp
Clini Med (invited), 2(5), 202-217, 2010.
38. G. T.-J. Huang*. Pulp and Dentin Tissue Engineering and Regeneration -- Current
Progress. Regenerative Med (invited), 4(5) 697-707, 2009. PMID: 19761395. Nih
39. G. T.-J. Huang*. Apexification: the beginning of its end. Int Endo J, June 2009. PMID:
19549154
40. G. T.-J. Huang*, S. Gronthos and S. Shi. Mesenchymal stem cells derived from dental
tissues vs. those from other sources: their biology and role in regenerative medicine
(invited). J Dent Res CROBM, Sep 2009. (cover page) PMID: 19767575. Nih (top 50 mostfrequently read article of JDR, top #4 as of Jan 2011)
41. G. T.-J. Huang*. A Paradigm Shift in Endodontic Management of Immature Teeth:
Conservation of Stem Cells for Regeneration. J Dent. 2008 Apr 15 [Epub ahead of print].
PMID: 18420332.
42. Huang G.T-J*, Sonoyama W, Liu Y, Liu H, Wang S, Shi S. The hidden treasure – stem
cells in apical papilla and their potential role in pulp/dentin regeneration and bio-root
engineering. J. Endodont, Available online 17 April 2008. PMID: 18436023
doi:10.1016/j.joen.2008.03.001
43. L. M. Lin*, G. T.-J. Huang, P. A. Rosenberg, Proliferation of Epithelial Cell Rests,
Formation of Apical Cysts, and Regression of Apical Cysts after Periapical Wound Healing.
J. Endodont, 33(8), 908-916, 2007. PMID: 17878074.
Book Chapters (invited)
44. G. T.-J. Huang*. Chapter: Pulp and Dentin Tissue Engineering and Regeneration.
(invited), "Endodontic topic” in prep.
45. L.M. Lin, and G. T.-J. Huang, Chapter: Pathobiology of the periapex, Pathways of the
Pulp, 2009/2010.
46. Huang, G.T.-J., Chapter on The Management of Endodontic Infections in Incompletely
Developed Teeth, Endodontic Microbiology, 2009.
47. W.-J. Li, K. Gollapudi, D. P. Patterson, G. T.-J. Huang, R. S. Tuan* Chapter: Cell-based
therapies for musculoskeletal repair. In Principles of Regenerative Medicine, eds, A. Atala,
R. Lanza, J.A. Thomson, R.M. Nerem. 2008.
48. Fouad A.F. and Huang, G.T.-J. Chapter 9: Inflammation and Immunological Response.
Ingle’s Endodontics – 6th Ed. 2008.
49. J. M. Taboas, C. K. Kuo, G. T.-J. Huang, and Rocky S. Tuan*. Chapter 5, Growth Factors
in Adult Stem Cell Based Tissue Engineering. In Translational Approaches in Tissue
Engineering and Regenerative Medicine; Artech House, Co-Editors: Jeremy Mao,
Gordana Vunjak-Novakovic, Antonios Mikos, Anthony Atala. 2007.
50. Kagnoff, M.F., Eckmann, L., Yang, S.-K., Huang, G.T.-J., Jung, H.C., Reed, S.L., Fierer, J.,
Intestinal Epithelial Cells: An Integral Component of the Mucosal Immune System (Chap. 6,
p63-71). Essentials of Mucosal Immunology, ed. by Kagnoff and Kiyono, Academic press,
San Diego, 1996.
51. Haake S.K. and Huang, G.T.-J., Molecular Biology of the Host-Microbe Interaction in
Periodontal Diseases: Selected Topics. (Chapter) Clinical Periodontology, 9th Edition.
Editors: Carranza FA, Newman MG, and Takei HH. W. B. Saunders Co., Philadelphia PA.
2002.
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Huang, George
Editorials
52. G T-J Huang and LM. Lin, Comments on the use of the term “revascularization” to describe
an endodontic procedure. J. Endodont, May 2008.
Editor
53. G T-J Huang et al “Stem cells and craniofacial development” in prep
Media coverage of research work
Boston Globe, Nov, 2010.
http://www.boston.com/business/healthcare/articles/2010/11/22/boston_scientists_see_big_p
otential_in_stem_cells_found_in_teeth/
BU today, Jan, Nov 2010
http://www.bu.edu/today/node/11853
http://www.bu.edu/today/node/10243
http://us.bioeden.com/broke-a-tooth-grow-it-back-bu-today/
http://stemsave.wordpress.com/
The Scientist, Feb, 2009
http://www.the-scientist.com/blog/display/57148/
Health Day News, 2006
http://news.healingwell.com/index.php?p=news1&id=536529
Abstracts
*Presenter
1. I. Yoon*, M. Al-Habib, G.T.-J. Huang. 3D model of dental stem cell attachment to MTA. J.
Dent. Res., 2011 (AADR/IADR).
2. V. TOM-KUN YAMAGISHI, C.D. TORNECK, S. FRIEDMAN, G.T.-J. HUANG, and M.
GLOGAUER. TLR2-Blockade Inhibits P.gingivalis Suppression of Mineralized Matrix
Formation by hDPSCs. J. Dent. Res., 2011 (AADR/IADR) (withdrawn)
3. K. Chan*, J. Liao, X. Yan, H. Qin, S. Shi and G. T.-J. Huang. Characterization of iPS cells
reprogrammed from stem cells with BCOR mutation. J. Dent. Res., 2011 (AADR/IADR)
4. J. Liao, M. Al Shahrani*, M. Al-Habib, T. Tanaka, G. T.-J. Huang. Characterization of
Human Mesenchymal Cells in Inflamed Periapical Tissue. J. Dent. Res., 2011
(AADR/IADR)
5. M. Al-Habib* & G. T.-J. Huang. Enhancement of Dental Pulp Stem Cell Stemness using small
molecules J. Dent. Res., 2011 (AADR/IADR) (won Pulp Biology & Regeneration Group
travel award) (session co-chair)
6. X. Yan, H. Qin, Q Qu, S. Shi, and G. T.-J. Huang. Human iPS cells reprogrammed from stem
cells with BCOR mutation. J. Dent. Res., 2010 (IADR). (session co-chair)
7. X. Yan1, H. Qin2, R.S. TUAN3, S. SHI2 G. T.-J. Huang1* . Teratoma formation by iPS cells
reprogrammed from dental stem cells. J. Dent. Res., 2010 (AADR).
8. H. Qin, X. Yan, S. Shi, and G. T.-J. Huang. iPS cells generated from OFCD patient as a
study model for developmental disorder. Int Soci Stem Cell Res., 2010.
9. D.J. Alongi, T. YAMAZA, Y. Song, R.S. TUAN, S. SHI. And G.T.-J. HUANG* Clonogenic
stem/progenitor cells from inflamed dental pulps remain capable of tissue regeneration. Int
Soci Stem Cell Res., 2009
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Huang, George
10. G.T.-J. HUANG*, TAKAYOSHI YAMAZA, L.D. SHEA, F. DJOUAD, and R.S. TUAN, S.
SHI. Regeneration of human pulp-/dentin-like tissues in emptied root canal space. J. Dent.
Res., 2009. (session co-chair)
11. D.J. Alongi*, A.F. Fouad, G.T.-J. Huang. Effect of inflammation on pulp stem cell potency.
J Endodont. 2009. (Won resident award – D. J. Alongi)
12. G.T.-J. HUANG*, L.D. SHEA, F. DJOUAD, S. SHI, and R.S. TUAN. Stem cell-mediated de
novo regeneration of human dental pulp. TERMIS (Tissue Engineering Regenerative
Medicine International Society), San Diego, CA, 2008. (Session co-chair).
13. G.T.-J. HUANG*, S. SHI, F. Djouad and R.S. TUAN. Lentiviral Vector-Mediated
Transduction of Human Mesenchymal Stem Cells. J. Dent. Res., 2008.
14. G.T.-J. HUANG*, S. SHI and R.S. TUAN. Characterization of Dental Stem Cells from Pulp
and Apical Papilla in vitro. J. Endodont., AAE, 2008.
15. G.T.-J. HUANG* Pulp Stem Cells for Pulp Regeneration. J. Endodont., 07-E-38-AAE,
2007.
16. G.T.-J. HUANG*, D. EGO-OSUALA, S.-H. PARK, L.D. SHEA, and R.S. TUAN. Pulp Stem
Cells Grown in Scaffolds and on Dentin. J. Dent. Res., #1447, 2007.(session chair)
17. C. Yin*, H.N. Dang, F. Gazor, and G.T.-J. Huang. Mouse salivary gland model for
antimicrobial gene therapy--technical considerations. J. Dent. Res., 2006
18. K. Shagramanova*, S. W. Chen, P. Aurasteh, I. Tam, G.T.-J. Huang. In vitro formation of
odontoblast-like cells on dentin. J. Dent. Res., 2006.
19. C. Yin* and G.T.-J. Huang. HBD-2 expression levels between naturally induced vs
genetically transduced cells. J. Dent. Res., 2005.
20. S.-H. Park, E.-J. Jung, E.-M. Rhim*, G.-W. Choi, G.-H. Lee, and G.T.-J. Huang, TNF-α
induces MMPs in pulp, gingival, and periodontal ligament cells. J. Dent. Res., 2005
21. S.-H. Park*, K.-J. Kim, S.-J. Park, S.-Y. Huh, H.-W. Lee, and G.T.-J. Huang. Substance P
and CGRP Induce Interleukin-8 by Human Gingival Cells. J. Dent. Res., 2005
22. D. Kim*, S.H. Park, and G.T.-J. Huang. Human pulp tissue engineering: an in vivo study
model. J. Dent. Res., 2005
23. James C. Chen* and G.T.-J. Huang. Characterizations of primary human pulpal stem cell
cultures -- A comparison of different methodologies and passages of cells. J. Endodont.
30(4):274 (abs#PR5), 2004.
24. M. Jung, S. Park*, and G.T.-J. Huang. Immunohistochemical Detection of Interleukin-8 in
Substance P-Stimulated Dental Pulp. J. Dent. Res. 83 (spec issue A) #1670, 2004.
25. D. Kim*, O. Sorensen, H.-B. Zhang, T. Ganz and G.T.-J. Huang. HBD-3 Transduction of
Cultured Human Cells using Retroviral Vectors. J. Dent. Res. 83 (spec issue A) #2722, 2004.
26. Audrey Lin,* Cortino Sukotjo, Kevin Song, Takahiro Ogawa, Ben Wu, George T.-J. Huang,
Ichiro Nishimura. Transfection of wit-3.0 accelerates wound contraction. J. Dent. Res. 83
(spec issue A) #1160, 2004.
27. H.N. Dang*, A. Toca, H.-B. Zhang S. K. Haake and G. T.-J Huang. Differential Regulation
of Cytokine Genes in Gingival Epithelial Cells Challenged by F. nucleatum and/or P.
gingivalis Analyzed with cDNA Array. J. Dent. Res. 82 (special issue B):B-226 (#1715),
2003.
28. S.H. Park, G. Y.W Hsiao* and G.T.-J. Huang. Role of Neuropeptides in Regulating the
Expression of IL-8 and MCP-1 in Human Dental Pulp. J. Dent. Res., 82 (special issue B):B185 (#1387), 2003.
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Huang, George
29. Park, S. H*, and Huang, G. T.-J. Characterization of Pulp Cell Behaviors Cultured in
Collagen Matrix. J. Dent. Res., 82 (special issue B):B-252 (#1927), 2003.
30. G.T.-J. Huang*, S.H. Park, and H.-B. Zhang. Transduction of human dental pulp cells with
retroviral vectors carrying HBD-2 cDNA. J. Dent. Res.., 82 (special issue B):B-46 (#0272),
2003. [Oral presentation]
31. S.A. Kinder Haake, S. Hunt Gerardo and G.T.-J. Huang. Fusobacterium nucleatum: A
Beneficial Pathogen? Anaerobe (2002) 8, 115–174.
32. Huang, G. T.-J*., Zhang H.-B., Kim, D., Park, S. H., Liu, L., and Ganz, T. Antimicrobial
gene therapy: in vivo demonstration of human -defensin-2 antimicrobial activities. Mol
Ther--Amer Soci Gene Therapy, 5(5):S258 (abs #788), 2002.
33. Han, D.C.*, G.T.-J. Huang, L.M. Lin, N. Warner, Gim, J. and A. Jewett. The role of
epithelium in periapical pathosis: A model system. J. Endodont., (abs#OR30), 28(3):242,
2002.
34. Patel, T.*, Park, S.H., Lin, L, and Huang, G.T.-J. Substance P Induces IL-8 and MCP-1
Production by Human Pulpal Cells. J. Endodont., (abs#PR43), 28(3):264, 2002.
35. Huang, G. T.-J *, and Haake, S. K. Differential Regulation of IL-8 mRNA in Gingival
Epithelial Cells by F. nucleatum or P. gingivalis. J. Dent. Res., 81 (special issue A):A-231
(#1758), 2002. [*Presenter was the program chair for the oral session]
36. Patel, T.*, Park, S.H., Lin, L, Chiappelli, F. and Huang, G.T.-J. Substance P, not Calcitonin
Gene-Related Peptide, Induces Interleukin-8 Production by Human Pulpal Cells. J. Dent.
Res., 81 (special issue A):A-44 (#0130), 2002. (Oral presentation)
37. Han, D.C.*, G.T.-J. Huang, L.M. Lin, N. Warner, and A. Jewett. Induced HLA Class
II/CD54 cell surface expression and cytokine production in oral epithelial cells challenged by
selected oral bacteria in vitro. J. Dent. Res., 81 (special issue A):A-490 (#4009), 2002. (Oral
presentation)
38. G.T.-J. Huang, A. Toca*, H.N. Dang, S.H. Park, H.-B. Zhang, and S.K. Haake. HBD-2
secreted by gingival epithelial cells is resistant to degradation by P. gingivalis, J. Dent. Res.
81 (special issue A) :A-283 (#2213), 2002.
39. Lin, L.*, Chugal, N, and Huang, G.T.-J., Endodontic failure: contributing factors. J. Dent.
Res. 80 (special issue IADR):654 (#1018), 2001.
40. Huang, G.T.-J.,* Kim, D., Kuramitsu, H. K. and Kinder Haake, S. Antagonistic Regulation
of IL-8 mRNA in Gingival Epithelial Cells by Porphyromonas gingivalis.. J. Dent. Res. 80
(special issue IADR):537 (#0084), 2001. (Oral Presentation)
41. Huang, G. T.-J., Kim, D.*, Liu, L., and Ganz, T. Functional Human -Defensin-2 Secreted
from NIH/3T3 Cells Transduced with Retrovirus Carrying HBD-2 Gene. J. Dent. Res. 80
(special issue IADR):679(#1224), 2001. (D. Kim received IADR student travel award to
present at IADR in Japan)
42. Huang, G. T.-J., Do, M., Park, J. S., Wingard, M. and Chugal, N.* Depletion of Interleukin6 Accelerates the Formation of Periapical Lesions after Pulp Exposure. J. Dent. Res. 80
(special issue IADR):680 (#1225), 2001.
43. Dryden, M., Kim, D., and Huang, G. T.-J.*. Anti-microbial effects of gutta-percha on oral
plaque. J. Endodont., (abs#PR10), March, 27(3):234, 2001.
44. Huang, G. T.-J.*, Kim, D., Liu, L. and Ganz, T. A model for antimicrobial gene therapy.
2001 Keystone Symposia, Gene Therapy 2001: A Gene Odyssey, Snowbird, Utah. (Poster
presentation).
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Huang, George
45. Huang, G. T.-J.,* Lee, J. K.-H., Kim, D., Kuramitsu, H. K. and Haake, S. K. Mechanism of
IL-8 regulation in gingival epithelial cells challenged with P. gingivalis. J. Dent. Res. 79
(special issue):176 (#261), 2000.
46. Huang, G. T.-J., Chugal, N.,* Potente, A. P., and Zhang, X. Constitutive expression of
interleukin-8 and intercellular adhesion molecule-1 in normal and inflamed human dental
pulps. J. Dent. Res. 79 (special issue):392 (#1987), 2000.
47. Huang, G. T.-J.*, Lee, J. K.-H., Kuramitsu, H. K. and Haake S. K. Reduced IL-8 protein
expression with increased IL-8 mRNA level in porphyromonas gingivalis infected epithelial
cells. Cold Spring Harbor Laboratory Meeting: Microbial Pathogenesis and Host Response.
Cold Spring Harbor, NY, 1999. (Poster presentation)
48. Huang, G. T.-J.*, and Zhang, X. Immunohistochemical Localization of IL-8 and ICAM-1 in
Normal and Inflamed Human Gingival Epithelium. J. Dent. Res., 78 (special issue B):188
(Abst # 664), 1999.
49. Potente, A. P.*, Kim, J.-W., Zhang, X. and Huang, G. T.-J., Expression of interleukin-8 in
normal and diseased dental pulps. J. Endodont., (abs#OR39), April, 24(4):281, 1998.
(Selected as top twelve abstracts submitted by resident (Potente) to American Association of
Endodontists 55th annual session for oral presentation)
50. Potente, A. P., Chugal, N.*, Kim, J.-W., Zhang, X. and Huang, G. T.-J., Detection of
interleukin-8 in normal and inflamed human dental pulps. J. Dent. Res., 77 (special issue
B):799 (Abst # 1340), 1998.
51. Han, Y.W.*, Huang, G. T.-J., Ngok, F.K., Kinder Haake S., Camargo, P., Park, N.H. and
Shi, W., Interactions between periodontal bacteria and human gingival epithelial cells. J.
Dent. Res., 77 (special issue B):1031 (Abst # 3197), 1998
52. Huang, G.T.-J.*, Hsu, W.L. and Park, N.-H., Increased ICAM-1 expression on transformed
human oral epithelial cells mediates lymphocyte adhesion and cytotoxcity. J. Dent. Res., 77
(special issue B):767 (Abst # 1084), 1998 [Oral Presentation].
53. Kagnoff, M.F., Eckmann, L., Huang, G., Yang, S.K., Kim, J.M. Intestinal epithelial
responses to enteroinvasive bacteria: The proinflammatory gene program and apoptosis
FASEB Journal Vol 12 (4,) Pages A362,1998.
54. Nguyen, J.*, Serene, T. and Huang, G.T.-J., In vitro biocompatiblity analysis of boronimplanted nickel-titanium. J. Endodont. (abs #OR8) April, 1997 [Oral Presentation].
55. Huang, G.T.-J.*, Chung, D.H., Kinder-Haake, S. and Park, N.-H., Coordinate regulation of
ICAM-1 and IL-8 by human gingival keratinocytes following periodontal bacteria invasion.
J. Dent. Res., 76:53 (abs#315) special issue, 1997 [Oral Presentation].
56. Huang, G.T.-J.* and Park, N.-H., Altered ICAM-1 expression in transformed human oral
epithelial cells. J. Dent. Res., , 76:53 (abs#2144) special issue, 1997 [Oral Presentation].
57. Nguyen, J.*, Huang, G.T.-J. and Serene, T., Cytotoxicity evaluation of boron-implanted
nickel-titanium. J. Dent. Res., 76:53, special issue (abs#2513), 1997.
58. Huang, G.T.-J.*, Eckmann, L., Fierer, J. and Kagnoff, M.F., Increased ICAM-1 expression
on human colon epithelial cells in response to bacterial invasion. Gastroenterology, 108:A404 (abstract#1616), 1995 [Oral Presentation].
59. Huang, G.T.-J.*, Eckmann, L., Fierer, J. and Kagnoff, M.F., Human colon epithelial cells
upregulate ICAM-1 expression following bacterial invasion. Clin. Immunol.
Immunopathol., 76(1):S86 (abstract #504), 1995 [Oral Presentation].
60. Kagnoff, M.F.*, Eckmann, L., Huang, G.T.-J., Kim, P.H., Jung, H., Fierer, J. and
Morzycka-Wroblewska, E., Cytokines regulate IgA production and provide early signals for
18
Huang, George
61.
62.
63.
64.
65.
66.
67.
68.
the activation of immune and inflammatory response in the mucosal environment. J. Cell.
Biochemistry, Suppl. 19A:234 (#J1-007), 1995.
Lennon, K., Huang, G.T.-J, Kukuruzinska, M.A. Molecular basis of hamster ALG7
transcript heterogeneity. J. Dent. Res 74: 196-196, sp. iss. si 1995.
Huang, G.T.-J.*, Eckmann, L. and Kagnoff, M.F., Differential use of polyadenylation sites
of secreted immunoglobulin alpha heavy chain from a single AAUAAA poly(A) signal.
Faseb J. 8(4):A255 (abstract #1477), 1994.
Mota, O.M.*, Huang, G.T.-J., Kukuruzinska, M.A., The ALG7 gene expression during
postnatal development of submandibular gland. J. Dent. Res., (abstract #1537), 1993.
Huang, G.T.-J.* and Kukuruzinska, M.A., Multiple polyadenylation signals in the 3’untranslated sequences of hamster salivary ALG7 gene. J. Dent. Res., 72:648 (abs #1061),
1992.
Huang, G.T.-J.* and Kukuruzinska, M.A., Molecular cloning and characterization of the
hamster salivary ALG7 gene. J. Dent. Res., 71:264 (abs# 1264), 1992 [Oral Presentation].
Huang, G.T.-J.* and Kukuruzinska, M.A., Expression of the first N-glycosylation gene in
salivary glands. J. Dent.Res., 70:312 (abstract # 374), 1991.
Huang, G.T.-J.*, Schilder, H. and Nathanson, D., Effects of moisture content and
endodontic treatment on some mechanical properties of human dentin. J. Dent. Res., 70:439
(abs # 1389), 1991.
Huang, G.T.-J.*, Schilder, H. and Nathanson, D., Effects of endodontic treatment on the
mechanical properties of human dentin. J. Endodont., 17 (4):194 (abs # 30), 1991. [Oral
Presentation]
Symposium presentations
1. G.T.-J. HUANG (speaker), Dental pulp regeneration and stem cells of the apical papilla,
sponsored by Pulp Biology and Regeneration group, Thursday, April 2, 2009: 8:00 AM-9:30 AM,
Location: C123 (Miami Beach Convention Center) IADR/AADR 2009.
Symposium organization (Program chair)
1. Stem cells, reprogramming, immunomodulation and cancer, AADR/IADR, 2011
G.T.-J. HUANG (speaker), Induced pluripotent stem cells – new foundation for medicine.
2. Translation of Stem Cell Biology To Craniofacial Regeneration: Challenges and
Opportunities. AADR/IADR, 2011.
G.T.-J. HUANG (speaker), Stem cell based therapy for regenerative endodontics (replaced
original speaker who withdrew)
SCHOLARLY ACTIVITIES
A. EXTRAMURAL SCHOLARLY COMMITMENT
 American Association of Endodontists Standing Committees:
Research and Scientific Affairs Committee – Member (2004-2006)
Responsibilities: Provides advice and expertise for those activities related to
research and scientific advances and affairs.
The committee meets two times per year to review research grant requests and to
review submissions for grad and faculty presentations at the annual session.
Regenerative Endodontics Committee – Member (2009- )
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Huang, George
Responsibilities: Provides advice and expertise for promoting and regulation of
the research and clinical work regarding regenerative endodontics.
The committee meets via conference calls several times a year and whenever
there is a need to meet.

External examiner
Temple University and Albert Einstein Med. Center Residency Programs
Oral mock board – 2006, 2008

AADR/IADR Pulp Biology and Regeneration Group
President (2011)
Vice President (2010) Program chair
Vice President-elect (2009)
Responsibilities: review abstracts
President-elect (2010)
Responsibilities : Program Chair for the AADR/IADR 2010
B. GRANT REVIEW
Extramural






Grant reviewer, NIH/MTE study section, Oct, 2009
Grant reviewer, NIH/ODCS supplement (revision) grant, July, 2009
Grant reviewer, NIH Challenge Grant (RC1), June, 2009
AAE grant reviewer, October, 2004; March & October 2005; March 2006.
Grant reviewer, special emphasis panel, NIDCR/NIH initiative (request for applications
– RFA for Development of in vitro models of human oral mucosa relevant to AIDS
and mucosal infections), November, 2004
Intramural
Student grant application, UCLA School of Dentistry, 2002, 2003, 2004
C. PEER REVIEWER FOR JOURNALS





As member of Scientific Advisory/Editorial Board
Journal of Experimental and Clinical Medicine (2008-)
Dental Hypothesis (2010-)
Journal of Endodontics (2003-)
The Open Dentistry Journal (2006-2010)
As regular reviewer for:
Stem Cells and Development
Tissue Engineering
Oral Diseases
Journal of Endodontics
Int Endodontic Journal
Oral Surg. Oral Med. Oral Path. Oral Radiol. Endod. (2006-2009)
Stem cell reviews and reports, 10
Med Micro Immun, Nov, 09
BMC Cell Biology, Nov, 09
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Cytotherapy, Nov, 09
J Exp & Clinical Med, 09
Stem Cells and Development, September, 08; Sept, Nov, 09
Tissue engineering, June, 09
Journal of Endodontics, regular reviewer, May 10
Journal of Endodontics, regular reviewer, January, Feb, March, April, May, Sept, 08
Journal of Endodontics, regular reviewer, January, April, June, Aug, Nov 07
Int. Endo J, Sept, 08
Clinical Medicine: Ear, Nose and Throat. June, 08
Archives of Oral Biology, June 08
Annals of Anatomy, Feb, 08
Archives of Oral Biology, Oct 07
Oral Surg. Oral Med. Oral Path. Oral Radiol. Endod., September, 07; April, Sept, 08
Oral Micro Immunol, ad hoc reviewer, June, 07
J. Dental Research, ad hoc reviewer, March, 07; Sept, 08
Ad hoc review for the impact of an scientific article regarding dental stem cells and
bio-root engineering, Scientific American, December, 06
Cell Death and Differentiation, ad hoc reviewer, December, 06
Matrix Biology, ad hoc reviewer, November, 06
Journal of Endodontics, reviewer, February, April, July, September, 2006
Oral Diseases, regular reviewer, May, August, Oct., Nov., 2006
Journal of Endodontics, reviewer, January, February, May, July, December (3
manuscripts), 2005
Archives Oral Biology, ad hoc reviewer, October, 2004
Journal of Endodontics, reviewer, Jan, March, June, July, August, September, 2004
CDA Journal, reviewer, March, 2004
Journal of Gene Medicine, ad hoc reviewer, January, 2004
Cytokine, ad hoc reviewer, January, 2004
Journal of Endodontics, reviewer, April, May, October, 2003
Journal of Endodontics
Serve on Scientific Advisory Board, as regular reviewer, April 2003
Journal of Endodontics, nominated as a reviewer, January 2003
Journal of the California Dental Association – March, June, 2002
Journal of Infectious Diseases, ad hoc -- December, 2001
Journal of the California Dental Association -- January, September 2001
Journal of the California Dental Association – March, August, 2000
D. SCIENTIFIC COMMITTEES
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Pulp Biology and Regeneration Group, IADR/AADR, 2009, Vice President elect

Pulp Biology and Regeneration Group, IADR/AADR, 2010, Vice President

Regenerative Endodontics Committee, AAE, 2010.
E. LECTURES AND PRESENTATIONS
(BASIC SCIENCE)
1. “Current advancement of experimental and clinical regenerative endodontics” ( 30 min)
15TH BIENNIAL CONGRESS ESE (Europ Soci Endodont) ROME 2011, Rome, Italy, Sep
14, 2011.
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Huang, George
2. “Dental stem cell markers” (30 min) The first International Conference on Dental and
Craniofacil Stem cells. Columbia University, NY, April 27, 2011.
3. “Dental pulp regeneration” (1 h) CDA (Canadian Dental Association Annual Conference),
Nova Scotia, Cananda, Aug 4, 2011
4. “Stem cells and regenerative dentistry” (1 h), Boston University, General Dentistry, Feb 15,
22, 2011.
5. “Current progress on dental stem cells” (1 h), Association for Dental Sciences, Taipei,
Taiwan, R.O.C., 2010.
6. “Cells, stem cells & reprogramming” (2.5 h) Taipei Medical University, Taipei, R.O.C.
Nov 25, 2010.
7. “Regeneration endodontics: from present to future of dental medicine.“ Schilder Symposium,
Organizer and speaker, Boston, MA, Oct 29, 2010.
8. “Immunoregulation and pathogenesis of Bone Resorption” (1.5 h), Bender, Seltzer &
Grossman Academic Review of Endodontology (3-day review lecture series), U Penn,
Philadelphia, PA, 9//10.
9. “Stem cells and regenerative endodontics” (4 h), Boston University Endodontic Alumni Fall
meeting, Scottsdale, AZ, Oct 16, 2010.
10. “Stem cells and regenerative endodontics” (4 h), Connecticut Academy of Endodontology,
Connecticut, Oct 6, 2010.
11. “iPS cells – a new foundation in medicine.” (1.5 h) Taipei Medical University, 2nd Annual
Conference on Tooth Banking, Stem Cell Research, and Development and their Clinical
Applications. May 30, 2010.
12. “Recent development of pulp tissue regeneration.” (2 h) Hong Kong University Faculty of
Dentistry. May 28, 2010.
13. “iPS cells and their clinical potential” (2 h) Peking University School of Stomatology, May
25, 2010.
14. “Stem cells and regenerative endodontics” (half-day), University of Alberta, 10th
Endodontic Day, Department of Dentistry, Edmonton, Alberta, Canada, May 1, 2010.
15. “It was stem cell all along.” Keynote Speaker, Science Day, Boston University, School of
Dentistry, Boston, MA, March 25, 2010.
16. “Inflammation and Immunoregulation” (1.5 h)
” Stem cells and regenerative endodontics” (1 h)
College of Diplomates and Columbia U Board Review Course. New York, NY, March 1214, 2010.
17. “iPS cells reprogrammed from mesenchymal-like stem cells of dental tissue origin” (1 h)
Dept of Molecular and Cell Biology seminar series, Boston U Dental Medicine, Oct, 09
18. “Immunoregulation and pathogenesis of Bone Resorption” (1.5 h), Bender, Seltzer &
Grossman Academic Review of Endodontology (3-day review lecture series), Albert
Einstein Medical Center, Philadelphia, PA, 9//09.
19. “Mesenchymal stem cells in dental and medical applications” (1 h) Fu Jen University,
Shinjhuan, Taiwan, ROC, 7/4/09.
20. “Mesenchymal stem cells in dental and medical applications” (1 h) Taipei Medical
University, School of Oral Medicine, Taipei, Taiwan, ROC, 7/3/09.
21. “Dental tissue-derived stem cells—biology and role in regenerative medicine” (1 h) Taipei
Medical University, School of Oral Medicine, Taipei, Taiwan, ROC, 7/2/09.
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22. “Dental tissue-derived stem cells—biology and role in regenerative medicine” (1 h) Fourth
Military University, School of Stomatology, Xi’an, China, 6/29/09.
23. “Dental tissue-derived stem cells—biology and role in regenerative medicine” (1.0 h),
University of Medicine and Dentistry of New Jersey, NJ, May 15, 09.
24. “Dental tissue-derived stem cells—biology and role in regenerative endodontics” (1.5 h),
Annual Convention for American Association of Endodontists, Florida, April, 09.
25. “Stem cells and their clinical applications” (1 h) Research Day Guest Speaker, Southern
Illinois University, IL, April 14, 09.
26. “Stem cell-based therapy for dental tissue regeneration” (1 h) Research Day Guest Speaker,
Southern Illinois University, IL, April 14, 09.
27. “Dental pulp regeneration and stem cells of the apical papilla” Speaker for Symposium:
Dental Pulp Degeneration and Regeneration, IADR/AADR, FL, 09
28. “The applications of stem cells in apical papilla in pulp/dentin regeneration and bioroot
regeneration” Regenerative Dentistry meeting, Nova Southeastern University, FL, Feb 13,
09.
29. “Stem cell based therapy for dental and craniofacial tissues” Taipei Medical University,
Taipei, Taiwan, Nov 7, 08.
30. “Stem cell banking for regenerative medicine” Taipei Cathay Hospital, Taipei, Taiwan,
Nov 6, 08
31. “Immunoregulation and pathogenesis of Bone Resorption” (1.5 h), Bender, Seltzer &
Grossman Academic Review of Endodontology (3-day review lecture series), Temple
University, Philadelphia, PA, 9/28/08.
32. “Dental tissue-derived stem cells for regenerative endodontics” University of Pennsylvania,
Philadelphia, PA, 9/10/08.
33. “Dental stem cell reprogramming” NIH/NIAMS, 7/08
34. “The Coming Era Of Regenerative Endodontics" Columbia University, New York,
12/7/07
35. "From Pink Pulp to Pink Gutta Percha to Pink Pulp Tissue -The Era Of Regenerative
Endodontics" Boston University Endodontic Alumni Annual Meeting, Boca Raton,
Florida, 10/20/07.
36. “Immunoregulation and pathogenesis of Bone Resorption” (1.5 h), Bender, Seltzer &
Grossman Academic Review of Endodontology (3-day review lecture series), University of
Pennsylvania, Philadelphia, PA, 9/28/07.
37. “Stem cell based orofacial tissue regeneration” (1 h), National Taiwan University Dental
School, Taipei, Taiwan, ROC, 7/05/2007.
38. “Stem cell based orofacial tissue regeneration--research staff and fellow panel discussion” (3
h), Kaohsiung Medical University Dental Research Institute, Kaohsiung, Taiwan, ROC,
7/03/2007.
39. “Stem cell based orofacial tissue regeneration” (1 h), Kaohsiung Medical University
Dental Research Institute, Kaohsiung, Taiwan, ROC, 7/03/2007.
40. “Stem cells, tissue engineering and Endodontics“ (45 min), Annual Convention for
American Association of Endodontists, Philadelphia, PA, 4/28/2007.
41. “Pathogenesis of Bone Resorption” (1.5 h), Bender, Seltzer & Grossman Academic Review
of Endodontology (3-day review lecture series), Albert Einstein Medical Center,
Philadelphia, PA, 9/8/06 -9/10/06.
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42. “Pulp Tissue Engineering” (1-hour), NIH/NIAMS, Intramural Research – Cartilage Biology
and Orthopedics Branch, Bethesda, MD, 8/16/06.
43. “Pulp Tissue Regeneration” (2-hour), Harvard University School of Dental Medicine,
Boston, MA, 4/21/06
44. “Pulp Tissue Engineering” (1-hour), Boston University School of Dental Medicine, Boston,
MA, 4/21/06
45. “Pulp Tissue Engineering” (1-hour), Johns Hopkins University Dept. Biomedical
Engineering, Baltimore, MD, 4/4/06
46. “Pulp Tissue Engineering” (2-hour), Department of Dentistry, Cathay Hospital, Morning
Meeting, Taipei, Taiwan, ROC, 3/2/06
47. “Clinical manifestations and the underlying mechanisms of endodontic diseases” (2-hour),
National Defense Medical University, Taipei, Taiwan, ROC, 3/1/06
48. “Pulp Tissue Engineering” (2-hour), Taipei Medical University, Taipei, Taiwan, ROC,
2/27/06
49. “Endodontology: an integral part of biomedical science” (whole-day), Academy of
Endodontology Republic of China, National Taiwan University, Taipei, Taiwan, ROC,
2/26/06
50. “Regenerative medicine for clinical endodontics” (1-hour), Department of Dentistry, ChiMei Hospital, Morning Meeting, Tainan, Taiwan, ROC, 2/22/06
51. “Mechanisms of Pulpal Pain” (2-hour), Department of Dentistry, Tainan Municipal
Hospital, Tainan, Taiwan, ROC, 2/21/06
52. “Pulp Tissue Engineering” (1 h), SUNY Stonybrook, School of Dental Medicine,
Stonybrook, New York, Sep. 29, 2005
53. “Pulp Tissue Engineering” (1 h), Boston University Endodontic Alumni Annual Meeting,
Washington DC , 9/22/05.
54. "Prospect of regenerative medicine for clinical endodontics" (1 h), Pulp Biology and
Endodontics Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
April 6, 2005.
55. “Tissue Engineering Technology for Pulp Tissue Regeneration and Beyond” (1 h),
University of Maryland, Department of Endodontics, Baltimore, MD, Mar. 4, 2005.
56. “Tissue Engineered Models for Infection Studies” (1 h), NIH/NIDCR, Intramural Research - Oral Infection and Immunity Branch, Bethesda, MD, Mar. 3, 2005.
57. Prospective Cutting Edge Biotechnologies for Endodontics—tissue engineering and gene
therapy” (1 h), Uni Toronto, School of Dentistry, Toronto, Canada, Jan. 10, 2005.
58. “Prospective Cutting Edge Biotechnologies for Endodontics—Tissue Engineering and Gene
Therapy” (1 h), Baylor College of Dentistry, TAMUSHSC, Departments of Endodontics,
Dallas, TX, Dec. 17, 2004.
59. “Cutting Edge Biotechnologies for Endodontics--From Diagnosis to Treatment” (2 h),
University of Maryland, Department of Endodontics, Baltimore, MD, Nov. 30, 2004.
60. “Cutting Edge Biotechnologies for Endodontics--From Diagnosis to Treatment” (2.5 h),
Albert Einstein Medical Center, to Departments of Endodontics of both Albert Einstein
Medical Center and University of Pennsylvania, Philadelphia, PA, Oct. 20, 2004.
61. “Cutting Edge Biotechnologies for Endodontics--From Diagnosis to Treatment” (2.5 h),
NYU Department of Endodontics, New York, Oct. 18, 2004.
62. “Cutting Edge Biotechnologies for Endodontics--From Diagnosis to Treatment” (2 h), Uni
Toronto, School of Dentistry, Toronto, Oct. 14, 2004.
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63. “Prospective cutting Edge Biotechnologies for Endodontics—tissue engineering and gene
therapy” (1 h), SUNY Stonybrook, School of Dental Medicine, New York, Sep. 16, 2004.
64. “Cutting Edge Biotechnologies for Endodontics--From Diagnosis to Treatment” (1.5 h),
Annual Convention for American Association of Endodontists, Anaheim, CA, May 7,
2004.
65. “Molecular Basis of Endodontic Infection--Foundation for Diagnosis and Treatment” (halfday), University of Alberta, Department of Dentistry, Edmonton, Alberta, Canada, April
7, 2003.
66. “Enhanced of Innate Immunity and Tissue Repair—Naturally Programmed or Man-Made” (1
hour), University of Southern California, Los Angeles, CA, 7/17/02.
67. “Enhanced Innate Immunity—Naturally Programmed and Man-Made” (1 hour), Center for
Craniofacial and Molecular Biology, University of Southern California, Los Angeles, CA,
10/25/01.
68. “Molecular Control of Endodontic Infection” (30 min), UCLA School of Dentistry, Board of
Counselors, Los Angeles, CA (4/25/01).
69. “Pulpal Inflammation—The kinetics” (1-hour), Cathay Hospital Dental Department,
Morning Meeting, Taipei, Taiwan, ROC, 1/10/99.
70. “Pulpal Inflammation—Little is Known” (1-hour) Boston University Endodontic Alumni
Annual Meeting, Greenbrier, West Virginia, 10/22/99.
71. “Studies of ICAM-1 and IL-8 Expression in Oral Diseases” (1-hour) UCLA Dental Research
Institute Seminar Series, Los Angeles, CA, 10-27-1998
72. “Upregulation of IgA Expression by Cytokines through Gene Activation and mRNA
Stabilization” (1-hour) UCLA Dental Research Institute Seminar Series, Los Angeles, CA,
2-14-1995.
1.
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7.
8.
CLINICAL SCIENCE
“Apexification: the end is now” (1.5 h), Hong Kong Endodontic Society, May 28, 2010.
“Apexification: the end is now” and “Current updates on clinical endodontics” (half-day),
University of Alberta, 10th Endodontic Day, Department of Dentistry, Edmonton, Alberta,
Canada, May 1, 2010.
“Regenerative endodontics and tooth regeneration” (1 h), Boston University, General
Dentistry Conference – update in general dentistry, April 9, 2010.
“Apexification: the beginning of its end”. BU Endo alumni Fall meeting, Oct, 09.
“Apexification: the beginning of its end”. Annual Convention for American Association of
Endodontists, FL, April, 09.
“Apexification: the beginning of its end”. National Taiwan University, Taipei, Taiwan,
Nov 6, 08
“A Paradigm Shift in Endodontic Management of Immature Teeth -Conservation of Stem Cells for Regeneration" (45min) Annual Convention for American
Association of Endodontists, Vancouver, British Columbia, Canada, 4/12/2008.
“A Paradigm Shift in Endodontic Management of Immature Teeth -Conservation of Stem Cells for Regeneration" (4 hr) Albert Einstein Medical Center,
Philadelphia, PA, 3/6/08.
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9. “A Paradigm Shift in Endodontic Management of Immature Teeth -Conservation of Stem Cells for Regeneration" (1 hr) National Taiwan University, Taipei,
Taiwan, ROC, 2/21/08.
10. “A Paradigm Shift in Endodontic Management of Immature Teeth -Conservation of Stem Cells for Regeneration" (4 hr) Kaoshiung Medical University,
Kaoshiung, Taiwan, ROC, 2/19/08.
11. “A Paradigm Shift in Endodontic Management of Immature Teeth -Conservation of Stem Cells for Regeneration" (1 hr) Endodontic Opinion Leaders Forum,
La Jolla, CA, 7/28/07.
12. “Immature teeth with periradicular periodontitis or abscess undergo apexogenesis – a
paradigm shift” Chinese American Dental Association in Southern California
Continuing Education Course, Los Angeles, CA, 6/07.
13. “Recent Advances in Clinical Endodontics” (2 h), UCLA Restorative and Endodontics
interdivisional/sectional seminar/conference. Los Angeles, CA, Feb. 24, 2004.
14. “Current concept in cleaning and shaping” (1-hour), Dept. of Dentistry, Wan-Fang
Hospital, Morning Meeting, Taipei, Taiwan, ROC, 11/11/99
15. “Current concept in cleaning and shaping and use of microscope” (1-hour), , Taipei Medical
College Hospital, Morning Meeting, Taipei, Taiwan, ROC, 11/9/99
16. “Current new advances in Endodontics and its future prospects” (whole-day), Chinese
American Dental Association in Southern California Continuing Education Course, Los
Angeles, CA, 10/11/98
17. “Vertical condensation in root canal obturation” (1.5 hour) Dental Student Endodontic Study
Club (UCLA), Los Angeles, CA, 10/5/98
18. “Advanced concepts in cleaning and shaping with NiTi instruments” (1.5-hour), Cercle
Parisien Endodontologie Appliquee (private study club), Paris, France, 6/30/98
19. “Current new advances in Endodontics” (1-hour), Dept. of Dentistry, National Taiwan
University Hospital, Morning Meeting, Taipei, Taiwan, ROC, 1/8/98
20. “Special cases presentation in Endodontics” (1-hour), Department of Dentistry, Cathay
Hospital, Morning Meeting, Taipei, Taiwan, ROC, 1/7/98
21. “Current new advances in Endodontics” (1-hour), Department of Dentistry at Veterans
Administration General Hospital, Morning Meeting, Taipei, Taiwan, ROC, 1/6/98
22. “Current new advances in Endodontics” (2-hour), Special Lecture to dental students, Taipei
Medical College, Taipei, Taiwan, ROC, 1/6/98
23. “Current new advances in Endodontics” (1-hour), Department of Dentistry, Ma-Jei
Hospital, Morning Meeting, Taipei, Taiwan, ROC, 1/5/98
24. “Current new advances in Endodontics” (1-hour), Der-Wei Dental Clinic (Private study
club), Taipei, Taiwan, ROC, 1/5/98
25. “Current new advances in Endodontics and its future prospects” (whole-day), Academy of
Endodontology Republic of China and Taipei Medical College Alumni Association,
Continuing Education course, Taipei, Taiwan, ROC, 1/4/98
26. “The current new advances in Endodontics” (2-hour), Kaohsiung Dental Association,
Kaohsiung, Taiwan, ROC, 12/30/97
27. “The current new advances in Endodontics” (4-hour), National Cheng-Kung University
Hospital and Tainan Dental Association, Tainan, Taiwan, ROC, 12/27/97
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28. “Introduction to warm gutta-percha technique” (2-hour) Chinese American Dental
Association in Southern California Continuing Education Course, Los Angeles, CA, 8/24/97
29. “Special cases presentation” (15 min) Ed Nutting San Diego Endodontic Seminar, San
Diego, CA, May, 1995
30. “Warm gutta-percha technique in Endodontics” (2-hour), Private study club, Kaohsiung,
Taiwan, ROC, Dec. 1994.
31. “The advantages of warm gutta-percha technique in Endodontics” (1-hour), National
Cheng-Kung University Hospital, Tainan, Taiwan, ROC, Dec. 1994
32. “The Esthetics of Endodontics” (2-hour), Taipei Dental Association and Taipei Medical
College Alumni Association, Taipei, Taiwan, ROC, Dec. 1994.
33. “Introduction of cleaning and shaping concepts for warm gutta-percha technique in
Endodontics” (2-hour) Private study club, Taipei, Taiwan, ROC, Sept. 1989.
F. RESEARCH COLLABORATION (extramural)
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2007-2009
National Taiwan University, Dr. Min-Huey Chen laboratory. Study of dental stem
cells and dental pulp regeneration using a minipig model.
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2007-2009
Kaoshiung Medical University, Dr. Chern Lai laboratory. Study of dental stem cells
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2006-2009
NIH/NIAMS Intramural Cartilage Biology and Orthopaedics Branch (Dr. Rocky
Tuan’s group), working on mesenchymal stem cells and tissue engineering.
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2005, NIH/NIDCR Intramural Oral Infection and Immunity Branch (Dr. Sharon Wahl’s
group), working on Laser Capture Microscopy and Affymetrix GeneChip.
4/18/06—4/19/06, Harvard University Dr. David Moooney’s lab of Cell and Tissue
Engineering, observing manufacture of PLG scaffolds.
G. CONTINUING EDUCATION AT UCLA, Columbia U, Boston U
1. “Endodontic management of immature teeth – conservation of stem cells for regeneration”
Boston University, March 12 (3 hrs), 2010.
2. “Endodontic management of immature teeth – conservation of stem cells for regeneration”
Continuing Education Course, Columbia U, Feb 27, 09 (1 h) .
3. “Introduction to warm gutta-percha technique in Endodontics” (1-hour lecture and 5-h
bench-top instruction) Endodontic Continuing Education Course, UCLA School of Dentistry,
Los Angeles, CA, 11-21-1998 (Presenter: self).
4. “Introduction to warm gutta-percha technique in Endodontics” (1-hour lecture and 4-h
bench-top instruction) Endodontic Continuing Education Course, UCLA School of Dentistry,
Los Angeles, CA, 8-15-1998 (Presenter: self).
5. “Introduction to warm gutta-percha technique in Endodontics” (1.5-hour lecture and 4-h
bench-top instruction) Endodontic Continuing Education Course, UCLA School of Dentistry,
Los Angeles, CA, 10-4-1997 (Presenter: self).
6. “Introduction to warm gutta-percha technique in Endodontics” (1.5-hour lecture and 4-h
bench-top instruction) Endodontic Continuing Education Course, UCLA School of Dentistry,
Los Angeles, CA, 8-2-1997 (Presenter: self).
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7. “Introduction to warm gutta-percha technique in Endodontics” (1.5-hour lecture and 4-h
bench-top instruction) Endodontic Continuing Education Course, UCLA School of Dentistry,
Los Angeles, CA, 3-8-1997 (Presenter: self).
8. “Introduction to warm gutta-percha technique in Endodontics” (0.5-hour lecture and 4-h
bench-top instruction) Endodontic Continuing Education Course, UCLA School of Dentistry,
Los Angeles, CA, 9-21-1996 (Presenter: self).
H. OTHER LECTURES ORGANIZED AT UCLA, Columbia U, Boston U
1. Co-organizer, Schilder/Gianelly Symposium, Boston University, (1 day) Oct 29, 2010.
2. Initiator and organizer of the lecture “Endodontic access cavity—the critical step for
success” (8-12 am), March 17, 1998 (Presenter: Dr. Yves Yana, Paris, France).
3. Initiator and organizer of the lecture “Use of NiTi rotary instruments for endodontic
treatment” (5:30-8:30 pm), March 22, 2000 (Presenter: Dr. Robert Augsburger, Tulsa, OK).
4. Initiator and organizer of a Dental Research Seminar. “Epithelial cells: an integral
component of the mucosal immune system.” (1-hour) 10-14-1997 (Presenter: Dr. Martin
Kagnoff, UCSD, La Jolla, CA)
5. College of Diplomates and Columbia U Board Review Course. New York, NY, March 1214, 2010.
6. Initiator and organizer of the Endodontic Microsurgery Continuing Education Course (to be
held in Nov, 09, whole day lecture and live demonstration) (Presenter: Dr. Syngcuk Kim, U
Penn, PA).
7. Initiator and organizer of the Endodontic Microsurgery Continuing Education Course held on
Feb. 5, 2000 (whole day lecture and live demonstration) (Presenter: Dr. John Stropko,
Scottsdale, AZ).
8. Co-organizer, Schilder/Gianelly Symposium, Boston U. Oct 29, 2010. One-day symposium.
INVENTIONS AND PATENTS
1. Dental stem cell derived iPS cells (Invention report, Columbia U, 2009)
2. Antimicrobial assay: In vivo simulation system (Invention Report filed-UCLA, 2002)
3. Pulpal tissue regeneration (Invention Report filed-UCLA, 2002).
4. Anti-tumor agents-- in preparation (not active)
5. Endodontic files—in preparation (not active)
PATIENT CARE--FACULTY GROUP PRACTICE
Limited to Endodontics (1995-2004, UCLA)
Time commitment: Year round, 2-3 half days/week
Responsibility: Treat private patients mostly referred from other UCLA faculty.
This is a required duty as a clinical faculty.
Limited to Endodontics (2005-, U Maryland)
Time commitment: Year round, one half day/week
CLINICAL & DIDACTIC TEACHING (U Maryland)
A. Courses chaired
1. Postgraduate
a. Biological basis of endodontics (2007-2008)
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B. Course Participated
1. Postgraduate
a. Classic and Current Endodontic Literature (2005-present)
b. Biological basis of endodontics (2005-present)
c. Resident case presentation (2006-present)
d. Clinical endodontics (2005-present)
e. Fundamentals of Endodontics (05-present)
f. DBMS 642 course review (07-present)
1. Predoctoral (Dental students):
a. Senior Endodontic Course (Endo 548) (2005-present)
Topic on:
“Management of Dental Trauma”
“Endodontic Surgery”
“Newer Endodontic Technology”
“Pulp Physiology and Pathology”
“Periapical Pathosis”
b. Junior Endodontic Course (Endo 538) (05-present
Topics on:
“Trauma to Teeth”
“Endodontic Emergencies I & II”
“Procedural errors”
“Pulp Physiology, Pathology and stem cells”
c. Endodontic Preclinical lab and lectures (Endo 522) (05-present)
d. Predoc Endodontic Clinic teaching (05-present)
e. BSCI 521A Pain and Analgesia (07)
Topic on “Dental pulp pain”
f. Fundamental Microbiology (06)
Topics on
“Host Response to Microbial Infection”
“Stem Cells”
g. Found. 511: Dental Anatomy and Occlusion
Topics on:
“Histology of the Pulp”
“The morphology of root canal system”
CLINICAL AND DIDACTIC TEACHING (UCLA)
A. Courses chaired or co-chaired:
1. Postgraduate
a. Advanced Endodontic Diagnosis and Treatment -DS 413c (chaired/lectured, 1999, 2000, 2002)
Time commitment: Spring quarters (course runs 1 h/week)
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Responsibility: Organize and select course contents and lecturers
Students: Third year dental students
b. Clinical Endodontics-DS 462c (chaired, lectured, 1999, 2003; co-chaired, 2000)
Time commitment: Spring quarters (course runs 1 h/week)
Responsibility: Organize and select course contents and lecturers
Students: Second year dental students
c. Endodontic Clinic –CL 403.01 a,b,c,s (chaired, clinic, 1999, 2000)
Time commitment: Year round (clinics run everyday)
Responsibility: Review and grade clinical cases completed by students
Students: Third year dental students
d. Endodontic Clinic –CL 404.01 a,b,c,s (chaired, clinic, 1999, 2000)
Time commitment: Year round (clinics run everyday)
Responsibility: Review and grade clinical cases completed by students
Students: Fourth year dental students
e. Endodontic Technique Seminar (chaired, 1999-2004)
Time commitment: Summer quarter (3 h/session, 3-5 sessions/quarter)
Responsibility: Teach hands-on advance Endodontic procedures on extracted teeth to
Endodontic Residents and Preceptors
Teacher/Student Ratio (each session): average 1/6
B. Clinical teaching (participated):
Endodontic clinical teaching (1995-2004)
Time commitment: Year round, 2-4 half days/week
Responsibility: Teach in the Endodontic Clinic to both predoctoral dental students and
postgraduate endodontic students (residents).
Teacher (faculty)/Student Ratio (each session): average 1/10
C. Didactic (course participated): (UCLA, U Maryland, BU)
I) Clinical Science:
Predoctoral Courses
a. Preclinical Endodontic Lab Course I (DS 462b, 1995-2004)
Time commitment: Winter quarters (4 h/week)
Responsibility: Teach second year dental students hands-on to perform endodontic
procedures on extracted teeth.
Teacher (Faculty)/Student Ratio (each session): average 1/15
a. Preclinical Endodontic Lab Course I (DS 462b, 1995-2004)
Time commitment: Winter quarters (4 h/week)
Responsibility: Teach second year dental students hands-on to perform endodontic
procedures on extracted teeth.
Teacher (Faculty)/Student Ratio (each session): average 1/15
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Huang, George
b. Preclinical Endodontic Lab Course II (DS 463s, 1998-2000)
Time commitment: Summer quarters (1-2 h/week)
Responsibility: Teach second year dental students hands-on to perform endodontic
procedures on extracted teeth.
Teacher (faculty)/Student Ratio (each session): average 1/15
c. Advanced Endodontic Diagnosis and Treatment -DS 413c (lecture, 1996-2003)
Time commitment: Spring quarters (1 h) (whole course runs 1 h/week)
Responsibility: Lecture to third year dental students, topics on
“Restoration of endodontically treated teeth” (1996-1998)
“Preparation for endodontic treatment” (1999-2002)
“Endodontic instruments” (2000, 2003)
Teacher/Student Ratio (each session): average 1/85
d. Introduction to Pre-Clinical Endodontics-DS 462a (lecture, 2001-2004)
Time commitment: Summer quarters (1 h/session) (whole course runs 1 h/week)
Responsibility: Lecture to second year dental students, topics on:
“Endodontic microbiology”
Teacher/Student Ratio (each session): average 1/85
e. Clinical Endodontics-DS 462c (lecture, 1999-2004)
Time commitment: Spring quarters (1 h/session) (whole course runs 1 h/week)
Responsibility: Lecture to second year dental students, topics on:
“Pulpal and periapical pathoses”
“Endodontic microbiology”
“Vital pulp therapy: direct and indirect pulp capping”
“Antibiotics for Endodontics”
Teacher/Student Ratio (each session): average 1/85
f. Clinical Endodontics-DS 463c (lecture, 2002)
Time commitment: Spring quarters (1 h/session) (whole course runs 1 h/week)
Responsibility: Lecture to second year dental students, topic on:
“Endodontic pain control”
Teacher/Student Ratio (each session): average 1/85
g. Treatment Planning II (1996)
Time commitment: Summer quarters (1 h) (whole course runs 1 h/week)
Responsibility: Lecture to second year dental students, topic on “Advanced Diagnostic
Methods”
Teacher/Student Ratio (each session): average 1/90
Postdoctoral Courses:
a. Basic and Current Literature Review in Endodontics (1995-)
Time commitment: Year round (3 h/session/week, 2-5 sessions/quarter)
Responsibility: Review, critique and discuss literature that covers various aspects in
the field of Endodontic with the Endodontic residents
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Huang, George
Teacher/Student Ratio (each session): average 1/6
b. Clinical Case Review (1996-)
Time commitment: Year round (2-3 h/session, 1-4 sessions/quarter)
Responsibility: Review, critique and discuss clinical cases completed by the
Endodontic residents. This is a one-on-one teaching process.
Teacher/Student Ratio (each session): average 1/1
c. Introduction to Endodontic Research (1996-2003)
Time commitment: (1-3 h/session, 2-3 sessions/year)
Responsibility: Introduce the concepts and methodologies of how to conduct an
original, scientific research to Endodontic residents.
Teacher/Student Ratio (each session): average 1/6
d. Endodontic Research (1996-)
Time commitment: Year round (no regular schedule)
Responsibility: Mentor and/or provide guidance to Endodontic residents to conduct
their research projects which are part of the requirements for the
certificate training.
Teacher/Student Ratio (each session): average 1/6
e. Endodontic Technique Seminar (1996-2004)
Time commitment: Summer quarter (3 h/session, 2-5 sessions/quarter)
Responsibility: Teach hands-on advance Endodontic procedures on extracted teeth to
Endodontic Residents and Preceptors
Teacher/Student Ratio (each session): average 1/6
d. Endodontic Oral Mock Board exam for second year residents (1997-2004 UCLA, 2005-U
Maryland)
Time commitment: Once a year (half-day)
Responsibility: Prepare exam materials and evaluate graduating residents’ overall
accomplishment in didactic and clinical training.
The format simulates the Board Certification process conducted by
the American Board of Endodontists
Teacher/Student Ratio (each session): 3/1
II) Basic Science:
Predoctoral Courses:
a. Oral Immunology (OB 472b, 2000-2001, 2004)
Time commitment: Winter quarters (1 h)
Responsibility: Lecture to second year dental students, topic on “Endodontic
Immunology”
Teacher/Student Ratio (each session): 1/80-90
Postdoctoral Courses:
a. Oral Biology Course OB 275 (Molecular Biology) (1997)
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Huang, George
Time commitment: Fall quarter (1 h)
Responsibility: Lecture to Graduate Oral Biology master and PhD students, topic on
“Post-Transcriptional Control of Gene Expression”
Teacher/Student Ratio (each session): average 1/15
b. Molecular Biology of Oral Diseases (1999, 2002)
Time commitment: Winter quarters (1 h)
Responsibility: Lecture to residents in Periodontics, topic on “Host Parasite
Interactions:Induction of Host Cytokines”
Teacher/Student Ratio (each session): average 1/10
c. Basic Processes in Oral Biology (2010-) (BU)
Time commitment: Spring quarters (1 h)
Responsibility: Lecture to residents in on “Stem cells” and “Tissue engineering”
Teacher/Student Ratio (each session): average 1/20
OTHER FUNDING HISTORY
1. Recipient of Electric Motor Grant Program from Dentsply (Tulsa Dental). Total of 19 motors and
contra angles (worth of $40,000) for both Resident Program and Undergraduate Program at UCLA.
April, 2000
GIFTS
1. Global Surgical Corp., $2,000 to sponsor CE course presented by Dr. John Stropko, Feb. 5, 2000
at UCLA.
INDUSTRY CONSULTANT
2003-2004
Discus Dental
2009-Present StemSave
VISITING SCHOLARS
1. Xinli Zhang, MD, PhD (7/97-6/98)
a) Country: P. R. China
b) Institute: Dept of Pathology, Third Military Medical University, Chongqing
c) Title at the Institute: Associate Professor
d) Publications (Projects done in my lab):
i) Huang, G.T.-J.* Zhang, X and Park, N.-H., Increased ICAM-1 expression in transformed
human oral epithelial cells: Molecular mechanism and functional role in peripheral blood
mononuclear cell adhesion and lymphokine-activated-killer cell cytotoxicity. Int. J.
Oncology, 17:479-486, 2000.
ii) Huang, G. T.-J.*, Chugal, N., Potente, A. P., and Zhang, X., Constitutive Expression of
Interleukin-8 and Intercellular Adhesion Molecule-1 in Human Dental Pulps. Int. J. Oral
Biol. 24(4):163-168, 1999.
iii) Huang, G. T.-J.*, Potente, A. P., Kim, J.-W., Chugal, N., and Zhang, X., Increased
interleukin-8 expression in inflamed human dental pulps. Oral Surg. Oral Med. Oral Path.
Oral Radiol. Endod., 88:214-20, 1999.
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Huang, George
iv) Huang, G. T.-J.*, and Zhang, X., Immunohistochemical Analysis of Interleukin-8 and
Intercellular Adhesion Molecule-1 in Human Gingival Epithelium. Int. J. Oral Biol., 24:716, 1999.
2. Sang Hyuk Park, DMD, MSD (4/01-12/02)
a) Country: South Korea
b) Institute: Dept of Conservative Dentistry (Endodontics), SungKyunKwan University, School of
Medicine, Seol Korea
c) Title at the Institute: Clinical Instructor
d) Projects being conducted in my lab:
(i) Pulp tissue engineering
(ii) IL-8 and MCP-1 regulation by SP in human dental pulps
e) Publications (Projects done in my lab):
(i) Patel, T., Park, S.H., Lin, L., Chiappelli, F. and Huang, G.T.-J.* Substance P Induces
Interleukin-8 Production from Human Dental Pulp Cells. Oral Surg. Oral Med. Oral Path.
Oral Radiol. Endod. Oral Surg. Oral Med. Oral Path. Oral Radiol. Endod. 96(4): 478485, 2003.
(ii) Park, S.H., Hsiao, G. and Huang, G.T.-J.* Role of Neuropeptides in the Regulation of
Interleukin-8 and Monocyte Chemoattractant Protein-1 Expression in Human Dental Pulp.
Int. Endodontic J. 37(3):185-192, 2004.
(iii) Patel, T.*, Park, S.H., Lin, L, and Huang, G.T.-J. Substance P Induces IL-8 and MCP-1
Production by Human Pulpal Cells. J. Endodont., (abs#PR43), 28(3):264, 2002.
(iv) Patel, T.*, Park, S.H., Lin, L, Chiappelli, F. and Huang, G.T.-J. Substance P, not Calcitonin
Gene-Related Peptide, Induces Interleukin-8 Production by Human Pulpal Cells. J. Dent.
Res., 81 (special issue A):A-44 (#0130), 2002. (Oral presentation)
(v) G.T.-J. Huang, A. Toca*, H.N. Dang, S.H. Park, H.-B. Zhang, and S.K. Haake. HBD-2
secreted by gingival epithelial cells is resistant to degradation by P. gingivalis, J. Dent. Res.
81 (special issue A) :A-283 (#2213), 2002.
f) Project conducted served as a partial requirement for the PhD degree given by the scholar’s
home country University in Korea.
3. Haibo Zhang, MD (4/01- 7/02)
a) Country: P. R. China
b) Institute: Cardiovascular Surgical Dept, 2nd Clinical Medical College of Harbin Medical
University, Harbin
c) Title at the Institute: Resident
d) Projects being conducted in my lab:
(i) Antimicrobial gene therapy
(ii) Antitumor gene therapy
e) Publications (Projects done in my lab):
(i) G.T.-J. Huang, A. Toca*, H.N. Dang, S.H. Park, H.-B. Zhang, and S.K. Haake. HBD2 secreted by gingival epithelial cells is resistant to degradation by P. gingivalis, J. Dent.
Res. 81 (special issue A) :A-283 (#2213), 2002.
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Huang, George
(ii) Huang, G. T.-J.*, Zhang, H.-B., Liu, L., Kim, D., and Ganz, T. A model for antimicrobial
gene therapy--Demonstration of human -defensin-2 antimicrobial activities in vivo using a
novel approach. Human Gene Therapy, 2002 Nov.
(iii) Huang, G. T.-J*., Zhang H.-B., Kim, D., Park, S. H., Liu, L., and Ganz, T.
Antimicrobial gene therapy: in vivo demonstration of human -defensin-2 antimicrobial
activities. Mol Ther--Amer Soci Gene Therapy, 5(5):S258 (abs #788), 2002.
(iv) G. T.-J Huang* H.N. Dang, H.-B. Zhang, and S. K. Haake. Differential Regulation of
Cytokine Genes in Gingival Epithelial Cells Challenged by F. nucleatum and/or P.
gingivalis. Microb. Pathog. 37(6):303-312, 2004.
f) Project conducted served as a partial requirement for the PhD degree given by the scholar’s
home country University in China.
POSTDOC and STUDENTS SUPERVISED/MENTORED IN MY LABORATORY AT UCLA,
Columbia U, Boston U.
Posdotc
1. Xiaoying Zou (Oct 10-)
a) Title of Project: iPS cells reprogrammed from dental mesenchymal cells.
b) Endodontics (Boston U)
c) Role: mentor
2. Xing Yang (Feb 09- March 10)
a) Title of Project: iPS cells reprogrammed from dental mesenchymal cells.
b) Endodontics (Columbia U)
c) Role: mentor
d) work published in Stem Cells Devel, 2009
PhD/DScD student
1. Audrey Lin, (6/02-05)
a) Title of Project: Wound healing and antimicrobial gene therapy
b) Biomedical engineering (UCLA)
c) co-mentored with Dr. Ichiro Nishimura (project mainly conducted in Dr. Nishimura’s lab)
2. Mey Alhabib (9/09-present)
a) Title of Project: Stem cell mediated dental tissue regeneration
b) DScD in Endodontics (BU)
c) Role: mentor
3. Candice Yang (7/10-present)
a) Title of Project: Neurogenic potential of dental stem cells
b) DScD in Endodontics (BU)
c) Role: mentor
Master’s students
1. Chunyi Yin (8/03-12/04, MS completed)
a) Title of Project: Study models for antimicrobial gene therapy
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Huang, George
b) Oral Biology MS student.
c) Role: mentor
2. Cathy Vu (MS, 10/02-12/04, completed)
a) Title of Project: Parathyroid hormone regulation of PTH-induced fragment 12 expression in
murine osteoblasts
b) Endodontic resident/Oral Biology MS program (UCLA)
c) Role: thesis committee member
3. David Han (certificate/MS research project, 10/00-6/02, MS completed)
a) Title of Project: Cytokines and MHC class II expression in epithelial cell of periapical granulomas
and cysts
b) Endodontic resident/MS (UCLA).
c) Role: co-mentored with Dr. Anna Jewett
d) Publication: Han, D.C., G.T.-J. Huang, L.M. Lin, N. Warner, Gim, J.S. and A. Jewett.*
Expression of MHC Class II, CD70, CD80, CD86 and pro-inflammatory cytokines is differentially
regulated in oral epithelial cells following bacterial challenge. Oral Microbiol. Immunol., 18:350358, 2003.
4. Tushar Patel, (DDS/MS student, 8/00-6/01, MS, not completed-student withdrawn from MS
program)
a) Title of Project: IL-8 regulation by SP in human dental pulps
b) Dental/MS Student (UCLA)
c) Role: Mentor
d) Research results published Oral Surg. Oral Med. Oral Path. Oral Radiol. Endod
5. Derek Ego-osuala (Endo certificate/MS, 9/07-5/08, not completed)
a) Title of Project: Periodontal ligament regeneration for avulsed teeth
b) Endodontic resident, U Maryland.
c) Role: Mentor
6. Dominick Alongi (Endo certificate/MS, 9/06-5/09, completed)
a) Title of Project: Effect of inflammation on pulp stem cell potency
b) Endodontic resident, U Maryland.
c) Role: Mentor
7. Philippe Gauthier (7/10-present)
a) Title of Project: Stem-cell based periodontal ligament regeneration
b) MScD in Endodontics (BU)
c) Role: mentor
Residents
1. Jan Nguyen, D.D.S. (certificate research project, 10/95-8/96)
a) Title of Project: A cytotoxic evaluation of boron-implanted nickel-titanium endodontic files
b) Endodontic resident (UCLA).
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Huang, George
c) Study project published in Journal of Endodontics (abstract) and presented in the annual
convention. J. Endodont., (abs #OR8) April, 1997 [Oral Presentation].
2. Anthony Potente (certificate research project, 10/96-8/98)
a) Title of Project: Expression of IL-8 and ICAM-1 in human dental pulps
b) Endodontic resident (UCLA).
c) Study project published in Journal of Endodontics (abstract) and presented in the annual
convention. Results also published in Int. J. Oral Biol. 24(4):163-168, 1999 and in Oral Surg. Oral
Med. Oral Path. Oral Radiol. Endod., 88:214-20, 1999.
3. Margaret Wingard (certificate research project, 10/96-8/98)
a) Title of Project: role of IL-6 in the formation of periapical lesions
b) Endodontic resident (UCLA).
c) Research results published in Oral Surg. Oral Med. Oral Path. Oral Radiol. Endod
4. Michael Dryden (certificate research project, 10/98-6/00)
a) Title of Project: Antimicrobial effect of gutta-percha on oral bacteria
b) Endodontic resident (UCLA).
5. Cathy Vu (certificate research project, 10/99-8/00)
a) Title of Project: Role of IL-8 on oral epithelial cell growth
b) AEGD resident (UCLA)
6. James Chen (certificate research project, 10/02-6/04)
a) Title of Project: Effect of culture systems on gene expression profile in dental pulp cells
b) Endodontic resident (UCLA)
7. Daniel Kim (certificate research project, 07/04-03/05)
a) Title of Project: Pulp tissue engineering
b) Endodontic resident (UCLA)
Dental Students
1. Patrick Lee (dental student research, 11/95-11/96)
a) Title of Project: Response of oral epithelial cells to Actinobacillus actinomycecometans invasion
b) DDS student (UCLA).
2. Lee Arca (dental student research, 11/95-2/97)
a) Title of Project: Response of oral epithelial cells to Porphyromonas gingivalis invasion
b) DDS student (UCLA).
c) Poster presentation at Annual Dental Student Research Presentation (1997, UCLA)
3. Dan Benjamin (student research, 8/97-2/98)
a) Title of Project: Detection of IL-8 in human dental pulps
b) DDS student (UCLA).
c) Abstract of the research results selected as top 5 in the Dental Student Research Competition
(1998, UCLA)
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Huang, George
4. Cindy Wang (dental student research, 3/98-7/99)
a) Title of Project: Detection of IL-8 in human dental pulps
b) DDS student (UCLA).
c) Abstract published in Dental Student Research Report (1999)
5. Michael Dote (dental student research, 6/98-7/99)
a) Title of Project: Detection of IL-8 in human dental pulps
b) DDS student (UCLA).
c) Abstract published in Dental Student Research Report (1999)
6. William Chen (dental student research, 9/98-1/99)
a) Title of Project: role of IL-6 in the formation of periapical lesions
b) DDS student, UCLA
7. Jin Park (dental student research, 1/99-5/00)
a) Title of Project: role of IL-6 in the formation of periapical lesions
b) DDS student, UCLA
c) Research results published: Oral Surg. Oral Med. Oral Path. Oral Radiol. Endod
8. Justin Hong (dental student research, 1/99-1/00)
a) Title of Project: role of IL-6 in the formation of periapical lesions
b) DDS student, UCLA
c) Research results published: Oral Surg. Oral Med. Oral Path. Oral Radiol. Endod
9. Michael Do (dental student research, 1/00-6/00)
a) Title of Project: role of IL-6 in the formation of periapical lesions
b) DDS student, UCLA
c) Research results published: Oral Surg. Oral Med. Oral Path. Oral Radiol. Endod
10. Tusha Patel (dental student research, 6/99-12/01)
a) Title of Project: Regulation of IL-8 by SP in human dental pulps
b) DDS student, UCLA
c) Research results published Oral Surg. Oral Med. Oral Path. Oral Radiol. Endod
11. Daniel Kim (dental student research, 7/00-8/04)
a) Title of Project: Expression of IL-8 and ICAM-1 by oral epithelial cells in response to
Actinobacillus actinomycecometans and Porphyromonas gingivalis invasion
b) UCLA graduate
c) Research results published in:
(i) Huang, G. T.-J.*, Zhang, H.-B., Liu, L., Kim, D., and Ganz, T. A model for
antimicrobial gene therapy--Demonstration of human -defensin-2 antimicrobial activities in
vivo using a novel approach. Human Gene Therapy, 2002
(ii) Huang, G. T.-J*., Zhang H.-B., Kim, D., Park, S. H., Liu, L., and Ganz, T.
Antimicrobial gene therapy: in vivo demonstration of human -defensin-2 antimicrobial
activities. Mol Ther--Amer Soci Gene Therapy, 5(5):S258 (abs #788), 2002.
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Huang, George
12. Grace Hsiao (Dental student research, 7/02-6/04)
a) Title of Project: Regulation of IL-8 by SP in human dental pulps
b) DDS student, UCLA.
c) Research results published in Int. Endodon. J.
13. Jason Cho (Dental student research, 11/03-present)
a) Title of Project: Pulp cells gene expression
b) DDS student, UCLA.
14. Selina Chan (Dental student research, 7/03-12/04)
a) Title of Project: Pulp stem cells isolation
b) DDS student, UCLA.
c) Publication: J Endodon, 2006
15. Irene Tam (Dental student research, 7/03-12/04)
a) Title of Project: Pulp stem cells isolation
b) DDS student, UCLA.
16. Kristina Shagramanova (Dental student research, 7/03-12/04)
a) Title of Project: Pulp stem cells isolation
b) DDS student, UCLA.
c) Publication: J Endodon, 2006
17. Panaz Auribach (Dental student research, 7/03-12/04)
a) Title of Project: Pulp stem cells isolation
b) DDS student, UCLA.
18. Derek Egoosuala (Dental student research, 9/05-present)
a) Title of Project: Pulp stem cells characterization
b) DDS student, U Maryland.
19. Kimberley Chan (Dental student research, Apex Program, 1/10-present)
a) Title of Project: ES gene expression by OFCD iPS cells
b) DMD student, Boston University
c) Award: Research won ADA/Dentsply award, BU Science Day, 2009.
OTHER SCHOLASTIC ACTIVITIES AND COMMUNITY SERVICES
Dec 2010
Invited to write recommendation letter to Dr. Qiang Zhu for his
promotion to Professor at University of Connecticut Health
Center School of Dental Medicine
8/21-22/10
Oct, 2009/2010
Endodontic Chair workshop, AAE, Chicago, IL
BU Endodontic Alumni Fall meetings.
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Huang, George
8/2/02
2001, 2004
10-16-00
8/19-8/20/00
5/5/00-5/11/00
5/4/00
2000, 2003
11/9/99
9/30/99-10/2/99
6/30/98
6/10/98
1/8/98
1/6/98
12/31/97
Meet with the program directors from University of Loma Linda,
University of Southern California, and Veteran’s Administration
Hospital at Long Beach to discuss program curricula and activities.
ADA (AAE) Program Directors Workshop. Chicago, IL.
Served as the study subject for the graduate student Megan AbbottMoore (University of Oregon Dept. of Anthropology) in her master’s
degree project.
ADA (AAE) Program Directors meeting on accreditation. Chicago, IL.
Accompanying Dr. No-Hee Park, Dean of UCLA School of Dentistry, to
visit Taipei Medical Collage for exchange of dental education experience.
Interviewed by TV station KCBS (California local CBS) for demonstrating
the use of a newly developed endodontic equipment “microfiberoptic
endoscope” manufactured by Fiberdent with Dr. James Buhcall at UCLA.
Attending Dr. Garry Carr’s seminar on Endodontic Microscope in
retreatment. Pacific Endodontic Research Foundation, San Diego, CA
Visiting and exchanging education experience with Dr. Lin-Hong Lin, Head
of Endodontics, Dental Department, Taipei Medical College Hospital,
Taipei, Taiwan, ROC
Dentsply/Tulsa Endodontic Educator Symposium. Dallas, Texas.
Visiting Paris University Dental School. Exchanged education experience
with Dr. Machtou, Paris, France
Received certificate of appreciation presented by Dr. Thomas Serene for
“Outstanding Contribution to Endodontic Research and Teaching” (UCLA).
Visiting and exchanging education experience with Dr. Chun-Pin Lin
(DDS, MS, PhD), Chairman of Endodontics, National Taiwan University,
School of Dentistry, Taipei, Taiwan, ROC
Visiting and exchanging education experience with Dr. Ching-Liang Meng
(DDS, DMSc), Executive Dean, National Defense Medical Center, Taipei,
Taiwan, ROC
Visiting and exchanging education experience with Dr. Chi-Cheng Tsai
(DMD, PhD), Director of Graduate Institute of Dental Sciences and Dean
of Kaushung Medical College, Kaohsiung, Taiwan, ROC
FUNDRAISE
1. Initiate fundraising to establish Fund of Endodontic for the Division of Endodontics at Columbia
University (2009)
2. Constant fundraising to BU endo alumni to maintain Endodontic Alumni Funds.
HOBBIES
1. Painting and short films.
2. Classical guitar and music composition (for classical guitar, piano).
3. Reading and Writing.
This is to state that the document prepared and presented in this CV is truthful
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George T.-J. Huang __
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