Biotechnology Lesson Plans for Advanced Placement Biology
Prior Learning:
 DNA structure and replication
 Central Dogma
 Control of Gene Expression
 Mutation and Disease/ Mutation and Cancer
Day
Student Activities
1
Biotechnology PPT
And Microarray Show
Homework:
SNP Analysis and Pharmacogenics
Paper Activity
Resources
A PPT is available on Wise’s website:
http://pages.cms.k12.nc.us/andreawise/apbiology.html
“Biotechnology for AP”
SNP Analysis Paper Activity
http://gslx.genetics.utah.edu
Click Teach Genetics (Top right)
Search SNP Analysis and Pharmocogenics
Also View
http://learn.genetics.utah.edu/content/labs/microarray/in
dex.html
2
3
EPIGENICS
Nova Video “Ghost in Your
Genes”
Begin Paper Lab from “DNA
CHIPS”
Due: SNP Analysis
CUSTOMIZED MEDICINEPHARMACOGENICS
Complete Carolina Kit “DNA Chips:
Genes to Disease Lab Kit”
Paper Lab and Simulation
Alternatively: Ghost in Your Genes
Microarray Simulation
Video: “Ghost in Your Genes” Nova, 56 minutes
There is a teacher’s guide for this:
www.pbs.org/nova/genes
For ordering kits: http://www.carolina.com
#211520 DNA CHIPS: Genes to Disease Lab Kit
For Dr. Sharon Bullock’s Customized Medicine Power
Point go to
http://pages.cms.k12.nc.us/andreawise/apbiology.html
And click “Customized Medicine Link”
Ghost in Your Genes Simulation
http://www.pbs.org/wgbh/nova/teachers/programs/3413
_genes.html
4
RELATED ISSUES
Complete and Debrief Previous
Information
Discussion: Genetic Screening
Here are some articles and a curriculum to guide a
discussion about genetic screening:
http://www.affymetrix.com/about_affymetrix/outreach/ed
ucator/microarray_curricula.affx
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NEXT
UNIT
TRANSFORMATION
Lab 6 PreLab
Paper Plasmid Lab
(Break out groups: Practice using
micropipette and loading wells)
TRANSFORMATION
Lab 6 Plasmid Lab
GEL ELECTROPHORESIS
APPLICATION
Forensic Lab (Outbreak) in
addition to AP Lab 6
Lab Questions Completed in
Class
Review all Biotech
AP Lab Manual: Lab 6
Ward’s Natural Science Has a straightforward Plasmid
Lab AP Lab 6 #88 V 8231
Any transformation will work.
Connie Wood (East Meck) suggests using Carolina
Biological’s “Outbreak” activity. She gets free DNA for
this.
TEST—GENE EXPRESSION,
CANCER, BIOTECHNOLOGY
In the Evolution Unit Molecular
Scientific American “Founder Mutations” October 2005
Genetics will be used in teaching
Includes
molecular evidence of evolution,
Haplotypes, Mutations, Genetic Recombination,
making molecular clocks, and in
Customized Medicine, Decent from Africa
Founder Mutations
Other Helpful Links: BioRad has Lessons and Power Points www.explorer.bio-rad.com