CURRICULUM VITAE
Name:
Gregory E. Lakin, M.D.
Position/Title: University of Pennsylvania Division of Plastic Surgery Post-Doctoral Research Fellow
Year
Field
Education:
Institution & Location
Degree Conferred
of Study
Duke University, Durham, NC
B.S.
Duke-in-Spain Program, Madrid, Spain
Duke-in-the-Andes Program, La Paz, Bolivia
Universidad Autónoma de Guadalajara, Mexico
Ponce School of Medicine, Ponce, Puerto Rico M.D.
University of Rochester, Rochester, NY
University of Pennsylvania, Philadelphia, PA
University of Rochester, Rochester, NY
1998
5/-7/96
8-12/96
1998-2001
2004
2004-2011
2007-2009
2009-2011
Biology, Spanish
Spanish
Spanish
Medicine
Medicine
General-Plastic Surgery Residency
Plastic Surgery Research
General-Plastic Surgery Residency
Postgraduate Training and Fellowship Appointments
July 2004—June 2005
Intern, Combined General-Plastic Surgery Residency, Strong Memorial Hospital,
University of Rochester School of Medicine, Rochester, NY
July 2005—June 2011
Resident, Combined General-Plastic Surgery Residency, Strong Memorial
Hospital, University of Rochester School of Medicine, Rochester, NY
July 2007—Present
Research Fellow, Division of Plastic Surgery, University of Pennsylvania School
of Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA
July 2009—June 2011
Resident, Combined General-Plastic Surgery Residency, Strong Memorial
(Expected)
Hospital, University of Rochester School of Medicine, Rochester, NY
Previous Research Experience
1993
University of Florida’s Florida Foundation for Future Scientists (FFFS) High School Summer
Student Science Training Program (SSTP), Gainesville, FL
Studied alligator infertility
PI: Paul Cardeilhac, Ph.D.
1995, 1997
University of Miami School of Medicine Division of Surgical Oncology, Miami, FL
Studied stereotactic breast cancer therapy and breast cancer in pregnancy
PI: David Robinson, M.D.
1997-1998
Duke University Biological Laboratories Independent Study Program, Durham, NC
Studied evolutionary phylogenetic reconstruction
Supported by Duke University Undergraduate Research Support Grant
PI: John Mercer, Ph.D.
2002
University of Texas MD Anderson Cancer Center Surgical Oncology, Medical Student Summer
Research Program, Houston, TX
Studied gene therapy for breast cancer and angiosarcoma of the breast
PI’s: Kelly Hunt, M.D. and Janice Cormier, M.D., M.P.H.
2007-present University of Pennsylvania Plastic Surgery Research Fellowship, Philadelphia, PA
Studying the role of mechanical stress on craniosynostosis, cleft palate gene therapy, molecular
regulation of palatogenesis, influence of maggot secretions on impaired wound healing, and
tissue engineering for craniofacial defects
Supported by the University of Pennsylvania Center for Human Appearance and The Children’s
Hospital of Philadelphia Children’s Surgical Associates
PI’s: Richard Kirschner, M.D. and Hyun-Duck Nah, D.M.D., Ph.D.
Publications
Peer-Reviewed Journal Articles
1. Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW, Pisters PWT, Ballo MT, Chen L,
Trent J, Burgess M, Patel S, Pollock RE, Cormier JN. Angiosarcoma of the breast. Cancer. 2005; 104:
2682-2688.
2. Lakin GE, Zoltick PW, Salhab I, Zajac A, Dienno JJ, Davis P, Bergelson JM, Kirschner RE, Nah HD.
Overexpression of IRF6 in the Medial Edge Epithelium of Embryonic Palatal Shelves Rescues the
Fusion Defect of a Tfgb3-/- Mouse Palate in Organ Culture. Manuscript in preparation to be submitted to
Developmental Biology.
Abstracts
1. Robinson DS, Lentz J, Moffat F, Franceschi D, Beber B, Korensky T, Lakin GE. The Role of
Stereotactic Mammographically Directed Core Biopsy for Non-Palpable Breast Lesions: A Single
Institutional Analysis of 196 Procedures. University of Miami School of Medicine Surgical Oncology
and Radiology, Miami, Florida 1995.
2. Spivak RM, Endo M, Zajac A, Zoltick PW, Lakin GE, Flake AW, Kirschner RE, Nah HD. In Utero
Delivery of Virally Encoded TGF-beta3 Rescues Cleft Palate in the TGF-beta3 Knockout Mouse.
Presented at the 87th Annual Meeting of the American Association of Plastic Surgeons in Boston, MA,
April 5-8, 2008.
3. Lakin GE, Spivak RM, Zajac A, Dienno JJ, Davis PF, Zoltick PW, Kirschner RE, Nah HD. Adenovirus
Encoding the IRF6 Gene Partially Rescues the Fusion Defect in a TGF-beta3-/- Mouse Embryonic
Palatal Organ Culture. Presented at the 65th Annual Meeting of the American Cleft Palate-Craniofacial
Association in Philadelphia, PA, April 14-18th, 2008.
4. Lakin GE, Zoltick PW, Zajac A, Kirschner RE, Nah HD. The Molecular Regulation of Palatogenesis:
Adenovirus-Mediated IRF6 Transduction of the Medial Edge Epithelium Rescues the Fusion Defect of
the TGF-beta3-/- Mouse Palate in Organ Culture. Presented at the 25th Annual Meeting of the
Northeastern Society of Plastic Surgeons in Philadelphia, PA, October 2-5, 2008.
5. Lakin GE, Zoltick PW, Zajac A, Kirschner RE, Nah HD. Discovery of a New Molecular Pathway in
Palatogenesis: IRF6 is an Important Downstream Effector of TGF-beta3 Signaling in Palatal Fusion.
Presented at the 88th Annual Meeting of the American Association of Plastic Surgeons in Rancho
Mirage, CA, March 21-25, 2009.
6. Wu C, Radecki A, Lakin GE, Salhab I, Flake AW, Kirschner RE, Nah HD. Intra-amniotic delivery of
an adenoviral vector expressing TGFβ3 rescues palatal fusion defect in TGFβ3 null mice. Presented at
the Annual Meeting of the Philadelphia Academy of Surgery in Philadelphia, PA, February 2, 2009.
7. Lakin GE, Zoltick PW, Salhab I, Kallewaard NL, Bergelson JM, Kirschner RE, Nah HD.
Overexpression of IRF6 in the Medial Edge Epithelium of Embryonic Palatal Shelves Rescues the
Fusion Defect in a TGF-b3-/- Mouse Palate in Organ Culture. Presented at the 19th Annual Children’s
Hospital of Philadelphia Research Poster Day in Philadelphia, PA, February 25th, 2009.
8. Lakin GE, Dienno JJ, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE, Nah HD.
Coxsackievirus and Adenovirus Receptor Expression Correlates with Adenoviral Tropism Towards the
Embryonic Mouse Palate. Presented at the 55th Annual Meeting of the Robert H. Ivy Society of Plastic
Surgeons in Pittsburgh, PA, April 17-18, 2009.
9. Lakin GE, Dienno JJ, Yang BH, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE, Nah HD.
Adenoviral Tropism Towards the Medial Edge Epithelium of the Embryonic Mouse Palatal Shelf
Correlates with Coxsackievirus and Adenovirus Receptor (CAR) Expression. Presented at the 66th
Annual Meeting of the American Cleft Palate-Craniofacial Association in Scottsdale, AZ, April 20-25,
2009.
10. Wu C, Lakin GE, Radecki A, Endo M, Kirschner RE, Nah HD. In Utero Somatic Transfer of TGFB3
and IRF6 Genes Rescues TGFb3−/− Induced Palatal Fusion Defects in Mice. Submitted to the 11th
International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies in Fortaleza, Brazil,
September 10-13, 2009.
11. Wu C, Lakin GE, Yang BH, Salhab I, Kirschner RE, Nah HD. IRF6 as a Downstream Effector of
TGFB3 Signaling in Palatogenesis: In Utero Somatic Delivery of Ad-IRF6 Rescues the Palatal Fusion
Defect in TGFβ−/− Mice. Submitted to the 13th Biennial International Congress of the International
Society of Craniofacial Surgery in Oxford, UK, September 26-30, 2009.
12. Lakin GE, Salhab I, Dienno JJ, Yang BH, Zoltick PW, Kallwaard NL, Bergelson JM, Kirschner RE,
Nah HD. Identification of a Target Receptor for Adenoviral Mediated Gene Delivery to the Palate: The
Coxsackievirus and Adenovirus Receptor (CAR). Submitted to the 26th Annual Meeting of the
Northeastern Society of Plastic Surgeons in Charleston, SC, Sept 23-27, 2009.
13. Lakin GE. Abstract in preparation for submission to the 89th Annual Meeting of the American
Association of Plastic Surgeons in San Antonio, TX, March 20-23, 2010.
Book Chapters
1. Robinson DS, Sundaram M, Lakin GE. “Carcinoma of the breast in pregnancy and lactation.” In
Bland KI, Copeland EM (eds): The Breast: A Comprehensive Textbook for the Management of Benign
and Malignant Diseases. Second Edition, Philadelphia, WB Saunders, 1998, pp 1433-1445.
2. Robinson DS, Sundaram M, Lakin GE. “Carcinoma of the breast in pregnancy and lactation.” In
Bland KI, Copeland EM (eds): The Breast: Comprehensive Management of Benign and Malignant
Diseases. Third Edition, Philadelphia, WB Saunders, 2004, pp 1475-1490.
Grants
1. Lakin GE, Nah HD, Kirschner RE. “Influence of Mechanical Stress on Muenke Syndrome
Craniosynostosis.” 2008 Plastic Surgery Educational Foundation Basic Research Grant Award Recipient
2. Lakin GE, Bartlett S, Nah HD, Kirschner RE. “Influence of Mechanical Stress on the Phenotypic
Variability of Muenke Syndrome Craniosynostosis.” 2008 American Society of Maxillofacial
Surgeons/Maxillofacial Surgeons Foundation & Synthes CMF Research Grant Award Recipient
3. Lakin GE, Nah HD, Kirschner RE. “Muenke Syndrome Craniosynostosis: Influence of Biomechanical
Stress on Phenotypic Variability” Submitted to the 2008 Cleft Palate Foundation, Children’s
Craniofacial Association Research Grant, Not awarded, Finished second place.
4. Lakin GE, Wu C, Liechty KW, Nah HD, Kirschner RE. “The Influence of Maggot Secretions on the
Healing of Impaired Wounds.” Submitted to 2009 Plastic Surgery Educational Foundation Wound Care
Fellowship. Not awarded.
Animal Protocol
2008-Present Lakin GE. The Children’s Hospital of Philadelphia, The Joseph Stokes, Jr. Research Institute.
“Microsurgical Skills Lab using Euthanized Rats” Principle Investigator, Hyun-Duck Nah.
Honors and Awards
2009
American Cleft Palate-Craniofacial Association Paul W. Black Junior Investigator Award
2008
American Society of Maxillofacial Surgeons/Maxillofacial Surgeons Foundation Research Grant
Award
2008
Plastic Surgery Educational Foundation Basic Research Grant Award
2008
Second Place Best Paper Presented at the Junior Investigator Competition, 65th Annual Meeting
of the American Cleft Palate-Craniofacial Association in Philadelphia, PA
2004
Ponce School of Medicine, M.D. with clinical distinction
2004
Who’s Who Among Students in American Universities and Colleges, Ponce School of Medicine
Professional Memberships
1999-Present American Medical Students Association (National Positions: Board of Trustees International
Trustee, Liaison to Educational Commission for Foreign Medical Graduates, Membership
Benefits Committee, House of Delegates Reference Committee, Membership Recruitment and
Fall Conference Committee 2001-2002; Resident Member 2004-Present)
2004-Present American College of Surgeons, Candidate Group Member
2007-Present American Society of Plastic Surgeons, Resident Member (Resident Coordinator 2008)
2008-Present American Cleft Palate and Craniofacial Association, Resident Member
2008-Present American Society for Reconstructive Transplantation, Trainee Member
2008-Present Northeastern Society of Plastic Surgeons, Resident Member
2008-Present Robert H. Ivy Society of Plastic Surgeons, Resident Member
2008-Present American Society of Maxillofacial Surgeons, Resident Affiliate Member
Presentations
2008
Grant Rounds, University of Pennsylvania Division of Plastic Surgery Lab Fellows Talk
2008
Invited Speaker, The Children’s Hospital of Philadelphia Pathology Core Laboratories
The Molecular Regulation of Palatogenesis: IRF6 is an Important Downstream Effector of
TGFβ3 Signaling in Palatal Development
2007-2008
University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia,
Division of Plastic Surgery Research Meeting
Adenovirus Transduction Kinetics Towards the Medial Edge Epithelium of the Developing
Mouse Palate
The Effects of Tensile Strain on Syndromic Craniosynostosis
A unique point mutation in the Fibroblast Growth Factor Receptor 3 gene (FGFR3) defines a
new craniosynostosis syndrome
Effects of compressive force on craniosynostosis
2006-2007
University of Rochester School of Medicine Plastic Surgery Journal Club
Component separation with Alloderm for large ventral hernias
Delayed hard palate repair in patients with cleft palate
Boomerang flap reconstruction for the breast
Structure and format of peer-reviewed scientific manuscripts and the history of hand surgery;
William Darrach, MD: his life and his contribution to hand surgery
Management of patients on anticoagulants prior to cutaneous surgery
2005-2006
University of Rochester School of Medicine Department of Surgery
Morbidity and Mortality presentation on perioperative management of diabetes
Morbidity and Mortality presentation on heparin induced thrombocytopenia
Blue Gold Conference on open ventral hernia repairs and comparison of meshes
Blue Gold Conference on incidental adrenal masses
Case Presentation Conference on oral maxillofacial surgery
Case Presentation Conference on cervical spine clearance in the ICU
Case Presentation Conference on obturator hernias
Case Presentation Conference on combined small intestine and liver transplantation
Case Presentation Conference on Lemierre’s Syndrome
Division of Pediatric Surgery Case Presentation Conference on pilonidal cyst
2002
Ponce School of Medicine, Ponce, Puerto Rico
Oncologic Hospital Tumor Board Case Presentation on lobular carcinoma in situ
Hospital Appointments
2008-Present Chestnut Hill Hospital General Surgery Moonlighter, Philadelphia, PA
2007-Present Children’s Hospital of Philadelphia Trauma Surgery Moonlighter, Philadelphia, PA
2007-Present Main Line Health Lankenau Hospital General Surgery Moonlighter, Wynnewood, PA
2007-2008
Penn Presbyterian Medical Center Urology & Gynecology Moonlighter, Philadelphia, PA
Other Experiences
1995-1996
Duke University Varsity Cross Country/Track Team
1997 – 1998 Spanish Interpreter, Duke University Medical Center, Durham, NC
1998-2004
Medical School Class Notes Service http://greglakin.tripod.com
1999-2000
Clinical Trustee for North America, North American Students Association, Universidad
Autonoma de Guadalajara
1999-2000
Founder and Chair, Fifth Pathway Committee, Universidad Autonoma de Guadalajara
2000 – 2001
2000-2001
2001-2002
2001-2002
2003-2004
2006-2007
Medschool.com International Medical Education Discussion Forum Moderator
Class Vice-President, Universidad Autonoma de Guadalajara
Senator, Academic Senate, Ponce School of Medicine
Student Representative, Liaison Committee on Medical Education, Ponce School of Medicine
President, Surgery Interest Group, Ponce School of Medicine
Member, Patient Safety Committee, University of Rochester