1
CURRICULUM VITAE: ING KANG HO
ADDRESS:
Office: National Health Research Institutes
35 Keyan Road, Zhunan Town
Miaoli County 350, Taiwan, R.O.C.
Tel: (037) 246-166 ext. 31010
Fax: (037) 582-946
e-mail: iho@nhri.org.tw
DATE OF BIRTH:
May 7, 1939
PLACE OF BIRTH:
Taiwan
CITIZENSHIP:
U. S. A.
MARITAL STATUS:
Married (Wife: Patricia, 3 children)
EDUCATION:
B.S., Chemistry, National Taiwan University
Taipei, Taiwan, 1962
Ph.D., Biochemistry, University of California
San Francisco, 1968
EMPLOYMENT::
Vice President
National Health Research Institutes – Present
Dean, School of Graduate Studies in the Health Sciences – 2001 - 2006
University of Mississippi Medical Center
Jackson, Mississippi 39216
Interim Associate Vice Chancellor for Research
and Graduate Studies, 1997- 2001
University of Mississippi Medical Center
Jackson, Mississippi 39216
Professor and Chairman, 1982 - 2006
Department of Pharmacology and Toxicology
University of Mississippi Medical Center
Jackson, Mississippi 39216
Billy S. Guyton Distinguished Professor, 1996 - 2004
formerly, Frederick A. P. Barnard Distinguished Professor, 1993 - 1996
University of Mississippi Medical Center
Jackson, Mississippi 39216
Director, Graduate Program in Pharmacology and Toxicology, 1982 - 2002
University of Mississippi Medical Center
Jackson, Mississippi 39216
Professor (Research), 1983 - 2006
Department of Anesthesiology
School of Medicine
University of Mississippi Medical Center
Jackson, Mississippi 39216
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Professor, 1978 - 1982
Department of Pharmacology and Toxicology
University of Mississippi Medical Center
Jackson, Mississippi
Associate Professor, 1975-1978
Department of Pharmacology and Toxicology
University of Mississippi Medical Center
Jackson, Mississippi
Assistant Professor in Residence, 1974-1975
Departments of Psychiatry and Pharmacology
University of California
San Francisco, California
Adjunct Assistant Professor, 1973-1974
Departments of Psychiatry and Pharmacology
University of California
San Francisco, California
Research Specialist, 1972-1973
Langley Porter Neuropsychiatric Institute
San Francisco, California
Assistant Research Pharmacologist, 1971-1972
Department of Pharmacology
University of California
San Francisco, California
Postgraduate Research Pharmacologist, 1970-1971
Department of Pharmacology
University of California
San Francisco, California
Instructor, 1969-1970
Department of Anesthesiology
Baylor College of Medicine
Houston, Texas
Research Associate, 1968-1969
Department of Anesthesiology
Baylor College of Medicine
Houston, Texas
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HONORS AND AWARDS:
Pharmaceutical Manufacturers Association Foundation,
Faculty Development Award in Basic Pharmacology, 1974-1976
President of Chinese Biologist Association, 1975-1977
Basic Science Teacher of the Year Award, School of Dentistry
University of Mississippi Medical Center, 1984, 1987
Fellowship Award from the Japan Society for the Promotion of Science, 1988
Professional Development Award in Geriatric Education,
Mississippi Geriatric Education Center, 1988
Fellow, American College of Clinical Pharmacology, 1988
Vice President, South Eastern Society of Pharmacology, 1987-1989
President, South Eastern Society of Pharmacology, 1989-1990
Visiting Professor, Chinese Academy of Preventive Medicine, Beijing, China, 1990
Honorary Professor, Institute of Industrial Health, China North Industries Group, Xian, China, 19901993
Visiting Professor, Nihon University, Tokyo, Japan, 1991
Secretary - Treasurer, Society of Chinese Bioscientists in America, 1990-1991
Vice President, American Chinese Toxicology Society, 1991-1993
Councilor, Association for Medical School Pharmacology, 1991-1993
Councilor, Society of Chinese Bioscientists in America, 1992-1996
President, American Chinese Toxicology Society, 1993-1995
Outstanding Scientific Achievement Award in Toxicology, Environmental Health and Sciences, Cheng
Hsing Medical Foundation and Society of Chinese Bioscientists in America, 1992
Billy S. Guyton Distinguished Professor, 1996-2003
(formerly Frederick A. P. Barnard Distinguished Professor, 1993-1996)
University of Mississippi Medical Center
Member, Academia Sinica, 1996
Councilor and Auditor, Asian Society of Toxicology, 1997-2000
President-Elect, Society of Chinese Bioscientists in America, 1998-1999
Award in Excellence for Basic Pharmacology
The Pharmaceutical Research and Manufacturers Association Foundation, 1998
Received the highest honor awarded in the health sciences from the Department of Health in Taiwan,
the Republic of China, 1999
Fellow, The Academy of Toxicological Sciences, 1999
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Member of Merit of the Pharmaceutical Society of Japan, 2000
President, Society of Chinese Bioscientists in America, 2000-2001
Editing Councilor, The Kaohsiung Jurounal of Medical Science, Taiwan, 2008-Present
SOCIETY MEMBERSHIPS:
American Society for Pharmacology and Experimental Therapeutics (1975)
Society for Neurosciences (1974)
Society of Toxicology (1977)
Western Pharmacology Society (1971)
Section of Toxicology, International Union of Pharmacology (1981)
Association of Medical School Pharmacology (1982)
Society of Chinese Bioscientists in America (1985)
American College of Clinical Pharmacology (1988)
South Eastern Society of Pharmacology (1987)
Asian Society of Toxicology (1997)
The Academy of Toxicological Sciences (1999)
The Pharmaceutical Society of Japan (2000)
RESEARCH SUPPORT:
June 1, 1973 - May 31, 1975, "Narcotic addiction: Morphine GABA interaction", $75,550, National
Institute on Drug Abuse - DA-00563
June 1, 1974 - May 31, 1975, "Mechanisms of barbiturate tolerance and dependence", $36,253,
National Institute on Drug Abuse - DA-00948.
July 1, 1974 - June 30, 1976, "Faculty Development Award in Basic Pharmacology", $48,346 (salary),
Pharmaceutical Manufacturers Association Foundation.
June 1, 1975 - May 31, 1977, "Mechanisms of barbiturate tolerance and dependence", $80,546,
National Institute on Drug Abuse, DA-01403.
May 1, 1977 - April 30, 1978, BRSG 5 S07 RR05386, "Effects of morphine administration on hepatic
ATPase activities", $2,100, University of Mississippi Medical Center.
June 27, 1975 - May 31, 1978, "Morphine-GABA interaction in tolerant-dependent subjects",
$130,498, National Institute on Drug Abuse, DA-01310.
June 1, 1977 - May 31 1980, "Mechanisms of barbiturate tolerance and dependence", $184,081,
National Institute on Drug Abuse. DA-01403.
September 15, 1978 - August 31, 1981, "Mechanisms of neurotoxicity induced by Kepone and mirex",
$132,754, National Institutes of Environmental Health Sciences, ES-01899.
August 1, 1979 - July 31, 1982, "Morphine GABA interactions in addicted subjects", $123,772,
National Institute on Drug Abuse. DA-01310.
August 1, 1981 - July 31, 1982, "Possible involvement of dopamine and gamma-aminobutyric acid in
DFP induced neurotoxicity", University of Mississippi Medical Center BRSG 5 S07 RR05386,
$2,500.
November 1, 1981 - October 31, 1984, "Basal ganglia dopamine--aminobutyric acid-acetylcholine
interaction in organophosphate-induced neurotoxicity, $405,642. U.S. Army Medical Research
and Development Command DAMD17-81-C-1238.
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November 15, 1984 - January 31, 1990, "Basal ganglia dopamine--aminobutyric acid-acetylcholine
interaction in organophosphate-induced neurotoxicity, $789,753. U.S. Army Medical Research
and Development Command DAMD17-85-C-5036.
January 1, 1987 - December 31, 1991, "Cocaine: Pharmaco-dynamic and -kinetic study in WKY and
SHR", $566,382. National Institute on Drug Abuse, 1 R01 DA04264.
May 1, 1989 - April 30, 1991, "Mechanism of action of butorphanol", $123,445. National Institute on
Drug Abuse, 1 R01 DA05828.
June 1, 1990-May 31, 1991, "Effects of DM-9384 on NMDA, GABAA and GABAB receptors", $56,640.
Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
September 1, 1987 - August 31, 1992, "Barbiturate tolerance-dependence and GABA system",
$546,292. National Institute on Drug Abuse, 1 R01 DA04480.
September 20, 1991-August 31, 1992, "ASIP-University of Mississippi Medical Center", $20,240.
National Institute on Drug Abuse, S15 DA07818.
May 1, 1991 - April 30, 1997, "Mechanism of action of butorphanol", $545,194. National Institute on
Drug Abuse, 1 R01 DA05828.
August 1, 1992 - July 31, 1997, "Barbiturate tolerance - dependence and GABA system", $723,992.
National Institute on Drug Abuse, 2 R01 DA04480.
July 15, 1997 - June 30, 2002, "Mechanism of action of butorphanol", $638,023. National Institute on
Drug Abuse, 1 RO1 DA05828.
September 1, 1998-March 31, 2000, “Dermal toxicokinetics of methyl parathion”, $249,940. Agency
for Toxic Substances and Disease Registry, Department of Health and Human Services.
September 30, 2000 – September 29, 2003, “Environmental signals and sensors: A virtual center for
disease prevention in human and ecosystems”, $4,330,403. Centers for Disease Control and
Prevention, Department of Health and Human Services, R06/CCR419466.
February 13, 2002-March 31, 2003, “Molecular and cell biological plasticity in the brain limbic system”,
$41,980. Japanese Human Science Grant Foundation.
November 1, 2003 – June 30, 2007, “Role of mu-opioid system in methamphetamine sensitization”,
$523,926, the Center of Psychiatric Neuroscience at the University of Mississippi Medical Center
which is supported by NIH Grant Number RR-P20 RR17701 from the National Center for
Research Resources.
November 10, 2004-November 9, 2009, “Alliance for Graduate Education in Mississippi”, $427,700,
National Science Foundation Training Grant
Journals for which refereeing or reviewing services have been performed:
Life Sciences
Science
Journal of Pharmacology and Experimental Therapeutics
Biochemical Pharmacology
Pharmacology, Biochemistry and Behavior
Neurotoxicology
Toxicology and Applied Pharmacology
Substance and Alcohol Actions/Misuse
Canadian Journal of Biochemistry
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Journal of Applied Behavior Analysis
Federation Proceeding
European Journal of Pharmacology
Physiology and Behavior
Proceeding of National Academy of Sciences, USA
Alcoholism: Clinical and Experimental Research
Fundamental and Applied Toxicology
Journal of Biochemical Toxicology
Journal of Neurochemistry
Medicinal Chemistry Research
Psychopharmacology
Brain Research
Annual Review of Pharmacology and Toxicology
University Committees:
Neurosurgery Chairperson Search Committee, 1978-1979
Laboratory Animal Care Committee, 1979-1987
Graduate Council, University of Mississippi, Medical Center, 1980-1997, Chairman, 1997-present
Executive Faculty Committee, School of Medicine, 1982 - present
Executive Faculty Committee, School of Dentistry, 1982 - present
Cancer Research Center Advisory Committee, 1982-1986
Consultant for Pharmacy and Therapeutics Committee, University of Mississippi Medical Center,
1982-1997
Student Promotions Committee (Basic Sciences), School of Medicine, 1982-present
Geriatrics Committee, 1985-present
Faculty Appointments, Promotions and Tenure Committee, School of Dentistry, 1984-1987; 19982002
Clinical Research Center Advisory Committee, University of Mississippi Medical Center, 1985-present.
Geriatric Education Center Advisory Committee, University of Mississippi Medical Center, 1985present
Library Director Search Committee, University of Mississippi Medical Center, 1986
Search Advisory Committee for Department of Pathology Chair, 1986-1988
Accreditation Self-Study Committee on Research, School of Dentistry, 1986-1988
Accreditation Self-Study Committee on Basic Science, School of Dentistry, 1986-1988
Faculty Promotion and Tenure, School of Medicine, 1986-1987; 1989-1992, (Chairman, 1991-1992)
Search Advisory Committee for Department of Physiology and Biophysics Chair, Chairman, 19881989
Outcomes Evaluation Committee, School of Dentistry, 1988
National Board Review Ad Hoc Committee, school of Dentistry, 1988
Search Advisory Committee for Department of Medicine Chair, 1989-1990
Agromedicine Advisory Committee, 1992-present
Search Advisory Committee for Vice Chancellor for Health Affairs and Dean of the School of
Medicine, 1993-1994
Search Advisory Committee for Chairman of Obstetrics and Gynecology, 1994-1995
Biomedical Research Grant Committee, 1996-1997, Chairman, 1997-present
Ad hoc Advisory Committee for Research and Development, Chairman, 1996-present
Bulletin Committee, 1997-present
Student Research Committee, School of Medicine, 1997-present
Compliance Committee, 1997-2001
Search Advisory Committee for Dean of School of Pharmacy, University of Mississippi, 2000-2001
Search Advisory Committee for Dean of School of Dentistry, 2001-2002
Information Systems Strategic Planning Committee, 2001-present
Faculty Development Committee, 2001-present
Student Development Services Committee, 2001-present
Search Advisory Committee for Dean, School of Nursing, 2001-2003
Search Advisory Committee for Chairman, Department of Microbiology, 2003-2005
Scientific, National and International Committees:
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Committee on Environmental Pharmacology, American Society for Pharmacology and Experimental
Therapeutics, 1980 - 1982
Organizing Committee of Section on Toxicology, American Society for Pharmacology and
Experimental Therapeutics, 1981
Consultant for the Mississippi Epidemiologic Studies Program sponsored by EPA, 1979 - 1980
Member of Editorial Board of NeuroToxicology 1980-1986
Special Alcohol Biomedical Research Review Committee, Alcohol, Drug Abuse and Mental Health
Administration, HHS. 1981
Award Committee, American Society for Pharmacology and Experimental Therapeutic, 1983; 19871989
Ad Hoc Member, General Research Support Review Committee, Division of Research Resources,
NIH, Sept., 1983-1988
Member, Task Force, American Heart Association, Mississippi Affiliate, 1984-1987.
Ad Hoc site visit member, Program of Research Center in Minority Institution, General Research
Review
Editorial Board, Alcohol and Drug Research, 1985-1987
Member, Drug Abuse Biomedical Research Review Committee (Pharmacology Research
Subcommittee), National Institute on Drug Abuse. Department of Health and Human Services,
1985-1989
Member, Expert Advisory Panel on Neurological and Psychiatric Disease, The United States
Pharmacopeial Convention, 1985-1990
Member of Editorial Board of Fundamental and Applied Toxicology 1988-1992
Member of Editorial Committee of Annual Review of Pharmacology and Toxicology, 1990-1994
Member, Drug Abuse AIDS Research Review Committee (Biobehavioral/ Clinical Subcommittee),
National Institute on Drug Abuse. Department of Health and Human Services, 1989-1993
Ad Hoc Consultant, National Heart, Lung, and Blood Institute, National Institutes of Health, 1990
Ad Hoc Consultant, Office of Review Activities, National Institute of General Medical Sciences,
National Institutes of Health, 1990
Scientific Advisor, National Laboratories of Foods and Drugs, Department of Health, Republic of
China, 1990-1996
Member, Scientific Advisory Committee for Planning of the National Health Research Institutes,
Department of Health, Republic of China, 1991-present
Member, Medical Biotechnology and Pharmaceutical Development Subcommittee, National Health
Research Institute, Republic of China, 1992-present
Member, Nominating Committee of American Society for Pharmacology and Experimental
Therapeutics, 1993
Member, Review Committee on Specialized Centers of Research in Ischemic Heart Disease, Sudden
Cardiac Death, and Heart Failure, National Heart, Lung and Blood Institute, National Institutes of
Health, 1994
Member, Board of Scientific Counselors of the Agency for Toxic Substances and Disease Registry,
Department of Health and Human Services, U.S.A. 1992-1997.
Chairman, Drug Abuse AIDS Research Review Committee (Biobehavioral/Clinical Subcommittee),
National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human
Services, 1993-1994
Member of Editorial Board of Journal of Biomedical Sciences, 1993-present
Member of Editorial Board of Journal of Food and Drug Analysis, 1994-present
Member of Editorial Board of Research Communications in Alcohol and Substances of Abuse,
1996-present
Science and Technology Consultant, Food and Drug Bureau, Republic of China, 1987-2000
Scientific Advisor, Narcotic Bureau, Department of Health, Republic of China, 1995-1996
Associate Editor, Annual Review of Pharmacology and Toxicology, 1995-2000
Member, Membership Committee of International Union of Toxicology, 1995-2001
Member, Scientific Council, National Health Research Institutes, Republic of China, 1996
Chairman, Low Dose Radiation Research Scientific Advisory Committee, National Health Research
Institutes, Republic of China, 1996-2000
Chairman, Recruitment and Evaluation Committee on Occupational and Environmental Health,
National Health Research Institute, Republic of China, 1996-1999
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Member, Neurophysiology and Neuroanatomy Research Subcommittee, National Institute on Drug
Abuse Initial Review Group, 1997-2001
Chairman, Advisory Committee to the Division of Environmental Health and Occupational Medicine,
National Health Research Institutes, Republic of China, 1999-2002
Member, Editorial Board, The Chinese Journal of Physiology, 1999-present
Member, ASIATOX Executive and International Advisory Committee, 2000
Reviewer, Scientific Review Committee II, National Health Research Institutes, Taiwan, Republic of
China, 2000-present
Member, National Health Research Institutes Scientific Council, Taiwan, Republic of China, 1999present
Member, Advisory Board, Institute of Biological Chemistry, Academia Sinica, Republic of China, 2001present
Member, Advisory Board, Institute of Zoology, Academia Sinica, Republic of China, 2001-present
Member, Advisory Board, National Research Program for Genomic Medicine, National Science
Council, Republic of China, 2002-present
Scientific Review Committee, National Science Council, Republic of China, 2002-present
Associate Editor, The Journal of Toxicological Sciences, 2002-2004
Member, Advisory Board, Journal of Pharmacological Sciences (JPS), 2003-2007
Member, Scientific Council for the National Research Program for Biotechnology and Drug
Development, National Science Council, Taiwan, 2002Chairman of the Scientific Advisory Committee, Division of Environmental health and Occuplational
Medicine, National Health Research Institutes, Taiwan 2002Delegate, Council Meeting of the National Health Research Institutes, Taiwan, September 5-7, 2002.
Member, Center for Disease Control Advisory Committee on Childhood Lead Poisoning Prevention,
2003-2007.
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PUBLICATIONS
1.
Ho, I. K. and Ellman, G. L. Triton solubilized acetylcholinesterase of brain. J. Neurochem. 16:
1505-1513, 1969.
2.
Ho, I. K. and Keats, A. S. Effect of anesthetics on sulfhydryl content of rat brain. Pharmacology 2:
257-264, 1969.
3.
Ungar, G., Ho, I. K., Galvan, L. and Desiderio, D. M. Isolation and identification of a specific
behavior-inducing peptide extracted from brain. Proc. West. Pharmacol. Soc. 13: 149-151,
1970.
4.
Ho, I. K., Loh, H. H. and Way, E. L. Mini thin layer chromatography in the detection of narcotics in
the urine. Proc. West. Pharmacol. Soc. 14: 183-186, 1971.
5.
Ho, I. K., Loh, H. H., Lu, S. E. and Way, E. L. Influence of p-chlorophenylalanine on morphine
tolerance and physical dependence. Proc. West. Pharmacol. Soc. 15: 16-20, 1972.
6.
Ho, I. K., Loh, H. H. and Way, E. L. Mini thin layer chromatography in the detection of narcotics in
urine from subjects on a methadone maintenance program. J. Chromat. 65: 577-579, 1972.
7.
Loh, H. H., Shen, F. H., Ho, I. K. and Way, E. L. Reserpine effects on morphine tolerance and
physical dependence. Proc. West. Pharmacol. Soc. 15: 1-3, 1972.
8.
Ho, I. K., Lu, S. E., Stolman, S., Loh, H. H. and Way, E. L. Influence of p-chlorophenylalanine on
morphine tolerance and physical dependence and regional brain serotonin turnover studies in
morphine tolerant-dependent mice. J. Pharmacol. Exp. Ther. 182: 155-165, 1972.
9.
Ho, I. K., Loh, H. H. and Way, E. L. Effect of L-tryptophan on morphine analgesia, tolerance and
physical dependence. The 34th Annual Scientific Meeting of the NAS-NRC Committee on
Problems of Drug Dependence, Ann Arbor, Michigan, p. 617-623, 1972.
10.
Loh, H. H., Ho, I. K., Cho, T. M. and Selenvinsku, C. Mini thin layer chromatogrpahy for the
estimation of amphetamine and methamphetamine. J. Chromat. 68: 289-293, 1972.
11.
Ho, I. K., Loh, H. H. and Way, E. L. Effect of cyclic AMP on morphine analgesia, tolerance and
physical dependence. Nature 238: 397-398, 1972.
12.
Hitzemann, R. J., Ho, I. K. and Loh, H. H. Narcotic tolerance dependence and serotonin turnover.
Science 178: 645-647, 1972.
13.
Ho, I. K., Loh, H. H. and Way, E. L. Cyclic AMP antagonism of morphine analgesia. J.
Pharmacol. Exp. Ther. 185: 366-376, 1973.
14.
Ho, I. K., Loh, H. H. and Way, E. Leong. Effects of cyclic AMP on morphine tolerance and
physical dependence. J. Pharmacol. Exp. Ther. 185: 347-357, 1973.
15.
Ho, I. K., Loh, H. H. and Way, E. Leong. Influence of 5,6-dihydroxytryptamine on morphine
tolerance and physical dependence. Eur. J. Pharmacol. 21: 331-336, 1973.
16.
Loh, H. H., Ho, I. K., Cho, T. M. and Lipscomb, W. Estimation of morphine by polyamide mini thin
layer chromatography. J. Chromat. 76: 505-508, 1973.
17.
Iwamoto, E. T., Ho, I. K. and Way, E. L. Elevation of brain dopamine during naloxone precipitated
withdrawal in morphine dependent mice and rats. Proc. West. Pharmacol. Soc. 16: 4-7, 1973.
10
18.
Ho, I. K., Loh, H. H. and Way, E. L. Influence of GABA on morphine analgesia, tolerance and
physical dependence. Proc. West. Pharmacol. Soc. 16: 14-16, 1973.
19.
Iwamoto, E. T., Ho, I. K. and Way, E. L. Elevation of brain dopamine during naloxone precipitated
withdrawal in morphine dependent mice and rats. J. Pharmacol. Exp. Ther. 187: 558-567,
1973.
20.
Ho, I. K., Sutherland, V. C. and Loh, H. H. A model for the rapid development of tolerance to
barbiturates. Res. Commun. Chem. Pathol. Pharmacol. 6: 33-46, 1973.
21.
Yamamoto, I., Ho, I. K. and Loh, H. H. Acceleration of tolerance development to barbiturates by
pellet implantation. Proc. West. Pharmacol. Soc. 17: 25, 1974.
22.
Tseng, L. F., Loh, H. H., Ho, I. K. and Way, E. L. The role of brain catecholamines in naloxoneinduced abstinence in morphine-dependent rats. Proc. West. Pharmacol. Soc. 17: 178-183,
1974.
23.
Ho, I. K., Loh, H. H. and Way, E. L. The GABA system in morphine analgesia, tolerance and
physical dependence. 36th Annual Scientific Meeting, Comm. Prob. Drug Dependence, NASNRC, p. 474-484, Mexico City, 1974.
24.
Lee, N. M., Ho, I. K. and Loh, H. H. Possible implications of gene expression with relation to
morphine tolerance. 36th Annual Scientific Meeting, Comm. Probl. Drug Dependence, NASNRC, p. 485-497, Mexico City, 1974.
25.
Ho, I. K., Yamamoto, I. and Loh, H. H. The rapid development of dispositional and adaptive
tolerance to barbiturates by pentobarbital pellet implantation. Eur. J. Pharmacol. 30: 164-171,
1975.
26.
Ho, I. K., Brase, D. A., Loh, H. H. and Way, E. L. Effect of L-tryptophan on morphine analgesia,
tolerance and physical dependence. J. Pharmacol. Exp. Ther. 193: 35-43, 1975.
27.
Ho, I. K. Effect of pharmacological manipulation of pentobarbital response. Proc. West.
Pharmacol. Soc. 18: 260-264, 1975.
28.
Ho, I. K., Loh, H. H., Bhargava, H. N. and Way, E. L. Effect of cyclic nucleotides and
phosphodiesterase inhibition on morphine tolerance and physical dependence. Life Sci. 16:
1895-1900, 1975.
29.
Ho, I. K., Yamamoto, I., Loh, H. H. and Way, E. L. Effects of the development of morphine
tolerance-dependence on pentobarbital responses. 37th Annual Scientific Meeting, Comm.
Prob. Drug Dependence, NAS-NRC, p. 586-594, 1975.
30.
Lee, N. M., Ho, I. K. and Loh, H. H. The effect of chronic morphine treatment on brain chromatin
template activities in mice. Biochem. Pharmacol. 24: 1983-1987, 1975.
31.
Ho, I. K., Yamamoto, I., Loh, H. H. and Way, E. L. Chronic administration of morphine on
pentobarbital responses in the mouse. Biochem. Pharmacol. 25: 357-358, 1976.
32.
Ho, I. K. Systematic assessment of tolerance to pentobarbital by pellet implantation. J. Pharmacol.
Exp. Ther. 197: 479-487, 1976.
33.
Ho, I. K. and Berndt, W. O. Chronic administration of pentobarbital on methadone analgesia and
toxicity. Life Sci. 18: 1305-1314, 1976.
11
34.
Ho, I. K., Yamamoto, I., Becker, K. E., Loh, H. H. and Way, E. L. Enhancement of pentobarbital
effect by chronic administration of morphine in the mouse. Life Sci. 19: 357-366, 1976.
35.
Iwamoto, E. T., Ho, I. K. and Way, E. L. Effect of pargyline on morphine tolerance and physical
dependence development in mice. Eur. J. Pharmacol. 38: 261-268, 1976.
36.
Desaiah, D. and Ho, I. K. Effect of biogenic amines and GABA on the ATPase system in mouse
tissues. Eur. J. Pharmacol. 40: 255-261, 1976.
37.
Ho, I. K., Loh, H. H. and Way, E. L. Pharmacological manipulation of gamma-aminobutyric acid
(GABA) in morphine analgesia, tolerance and physical dependence. Life Sci. 18: 1111-1124,
1976.
38.
Way, E. L., Iwamoto, E. T., Khanna, S., Ho, I. K., Shen, F. and Loh, H. H. Precipitation of
abstinence-like syndrome in morphine dependence mice by pargyline. J. Pharmacol. Exp.
Ther. 199: 400-407, 1976.
39.
Tzeng, S. F. and Ho, I. K. GABA system in pentobarbital induced narcosis and tolerance.
Biochem. Pharmacol. 26: 699-704, 1977.
40.
Desaiah, D. and Ho, I. K. Effect of morphine on mouse brain ATPase activities. Biochem.
Pharmacol. 26: 89-92, 1977.
41.
Desaiah, D., Hayes, A. W. and Ho, I. K. Effect of rubratoxin B on ATPase activities in mouse
tissue. Toxicol. Appl. Pharmacol. 39: 71-79, 1977.
42.
Desaiah, D., Ho, I. K. and Mehendale, H. M. Effects of kepone and mirex on mitochondrial Mg++
ATPase activity in rat liver. Toxicol. Appl. Pharmacol. 39: 219-228, 1977.
43.
Mehendale, H. M., Takanaka, T., Desaiah, D. and Ho, I. K. Kepone induction of hepatic mixed
function oxidases in the male rat. Life Sci. 20: 991-998, 1977.
44.
Yamamoto, I., Ho, I. K. and Loh, H. H. Acceleration of pentobarbital metabolism in tolerant mice
induced by pentobarbital pellet implantation. Life Sci. 20: 1353-1362, 1977.
45.
Desaiah D., Ho, I. K. and Mehendale, H. M. Inhibition of mitochondrial Mg++ ATPase activity in
isolated perfused rat liver by kepone. Biochem. Pharmacol. 26: 1155-1159, 1977.
46.
Desaiah, D. and Ho, I.K. Kinetics of catecholamine sensitive Na+-K+ ATPase activity in mouse
brain synaptosomes. Biochem. Pharmacol. 26: 2029-2034, 1977.
47.
Ho, I. K., Loh, H. H. and Way, E. Leong. Morphine analgesia, tolerance and dependence in mice
from different strains and venders. J. Pharm. Pharmacol. 39: 583-584, 1977.
48.
Becker, K. E., Jr. and Ho, I. K. Pentobarbital distribution in discrete brain areas of tolerant and
non-tolerant mice. Res. Commun. Chem. Pathol. Pharmacol. 18: 123-128, 1977.
49.
Tzeng, S. F. and Ho, I. K. Acute and continuous morphine administration on the -aminobutyric
acid system in the mouse. Prog. Neuro-Psychopharm. 2: 55-64, 1978.
50.
Yamamoto I. and Ho, I. K. Sensitivity to continuous administration of pentobarbital in different
strains of mice. Res. Comm. Chem. Pathol. Pharmacol. 19: 381-388, 1978.
51.
Yamamoto, I., Ho, I. K. and Loh, H. H. The antagonistic effects of pentobarbital alcohol on
pentobarbital narcosis in both naive and tolerant mice. Life Sci. 22: 1103-1112, 1978.
12
52.
Phillips, T. D., Hayes, A. W., Ho, I. K. and Desaiah, D. Effects of rubratoxin B on the kinetics of
cationic and substrate activation of Na+-K+ ATPase and para-nitrophenyl phosphatase. J.
Biol. Chem. 253: 3487-3493, 1978.
53.
Mehendale, H. M., Takanaka, A., Desaiah, D. and Ho, I. K. Effects of preexpose to kepone on
hepatic mixed function oxidases in the female rat. Toxicol. Appl. Pharmacol. 44: 171-180,
1978.
54.
Thureson-Klein, A., Wang-Yang, J. R. and Ho I. K. Lipid accumulation in mouse hepatocytes
after morphine exposure. Experientia 34: 773-774, 1978.
55.
Mehendale, H. M. and Ho, I. K. Effects of preexposure to morphine and pentobarbital on hepatic
disposition of methadone. Toxicol. Appl. Pharmacol. 45: 871-882, 1978.
56.
Hayes, A. W. and Ho, I. K. Interaction of rubratoxin B and pentobarbital in mice. J. Environ.
Pathol. Toxicol. 1: 491-500, 1978.
57.
Sun, G. Y., Hallett, D. W. and Ho, I. K. Effect of morphine on hepatic lipid metabolism. Biochem.
Pharmacol. 27: 1779-1782, 1978.
58.
Desaiah, D. and Ho, I. K. Effects of acute and continuous morphine administration on
catecholamine-sensitive ATPase in mouse brain. J. Pharmacol. Exp. Ther. 208: 80-85, 1979.
59.
Berndt, W. O. and Ho, I. K. Effects of morphine and pentobarbital on mouse and rat renal
transport mechanisms. Toxicol. Appl. Pharmacol. 48: 263-272, 1979.
60.
Ho, I. K. and Gilliland, T. The effects of acute and continuous morphine administration on the
affinity of glutamic acid decarboxylase for pyridoxal 5'-phosphate. Biochem. Pharmacol. 28:
355-360, 1979.
61.
Desaiah, D., Phillips, T. D., Hayes, A. W. and Ho, I. K. Effects of the aflatoxins on ATPase
activities in mouse and rat liver. J. Environ. Sci. Health, Part B 14: 265-278, 1979.
62.
Flint, B. A. and Ho, I. K. Evaluation of Dopram  and its effects on hexobarbital narcosis. Res.
Comm. Chem. Pathol. Pharmacol. 21: 271-279, 1979.
63.
Mehendale, H. M., Ho, I. K. and Desaiah, D. Possible molecular mechanism of mirex-induced
hepatobiliary dysfunction. Drug Metab. Disp. 7: 28-33, 1979.
64.
Chang, Y-Y. H. and Ho, I. K. Effects of acute and continuous morphine administration on serum
glutamate oxalacetate transaminase and glutamate pyruvate transaminase activity in the
mouse. Biochem. Pharmacol. 28: 1373-1377, 1979.
65.
Sun, G. Y. and Ho, I. K. Morphine-induced changes in prostaglandin precursor fatty acids in
phospholipids of mouse liver and serum. Life Sci. 24: 751-757, 1979.
66.
Chang, Y.-Y. H. and Ho, I. K. Effects of acute and chronic administration of pentobarbital on
catecholamine uptake in mouse brain synaptosomes. Res. Comm. Chem. Pathol.
Pharmacol. 23: 465-474, 1979.
67.
Flint, B. A., Ho, I. K., Mo, B. P. N. and Rigor, B. M. Enhancement of pharmacologic responses of
pentobarbital by dopram. Clinical Toxicol. 15: 169-179, 1979.
68.
Ho, I. K., Loh, H. H. and Way, E. L. Toxic interaction between choline and morphine. Toxicol.
Appl. Pharmacol. 51: 203-208, 1979.
13
69.
Chang-Tsui, Y.-Y. H. and Ho, I. K. Effects of Kepone (chlordecone) on synaptosomal aminobutyric acid binding activity in the mouse. Neurotoxicology 1: 357-367, 1979.
70.
Mehendale, H. M., Onoda, K., Curtis, L. R. and Ho, I. K. Induction of hepatic mixed function
oxidases by photomirex. J. Agr. Chem. 27: 1416-1418, 1979.
71.
Ho, I. K., Chang, Y.-Y. H., Fontenot, J. and Mehendale, H. M. Potentiation of mortality by carbon
tetrachloride during morphine pellet implantation in the mouse. J. Environ. Pathol. Toxicol. 3:
387-397, 1979.
72.
Desaiah, D., Ho, I. K. and Mehendale, H. M. Possible molecular mechanisms of mirex- and
Kepone-induced hepatobiliary dysfunction. Proc. Symp. Environ. Biol. 113-131, 1979.
73.
Chang-Tsui, Y.-Y. H. and Ho, I. K. Enhancement of carbon tetrachloride elevated glutamate
oxalacetate transaminase and glutamate pyruvate transaminase by acute and continuous
pentobarbital administration. Clinical Toxicol. 16: 41-50, 1980.
74.
Chang-Tsui, Y.-Y. H. and Ho, I. K. Effect of Kepone (chlordecone) on synaptosomal
catecholamine uptake in the mouse. Neurotoxicology 1: 643-652, 1980.
75.
Flint, B. A. and Ho, I. K. Rapid development of tolerance to and physical dependence on barbital
by pellet implantation. J. Pharmacological Methods 4: 127-139 1980.
76.
Ho, I. K. Effects of acute and chronic administration of pentobarbital on GABA system. Brain
Res. Bulletin 5: Suppl. 2, 913-917, 1980.
77.
Huang, D. T.-P., Ho, I. K. and Mehendale, H. M. Neurotoxicity induced by oral administration of
chlordecone (Kepone) in the mouse. Neurotoxicology 2: 113-124, 1981.
78.
Desaiah, D., Gilliland, T., Ho, I. K. and Mehendale, H. M. Inhibition of mouse brain synaptosomal
ATPase and 3H-ouabain binding by chlordecone. Toxicology Letters 6: 275-285, 1980.
79.
Onoda, K. and Ho, I. K. The inhibition and potentiation of procarbazine on hepatic mixed-function
oxidases in naive and pentobarbital tolerant mice. Drug Chem. Toxicol. 3: 185-200, 1980.
80.
Flint, B. A. and Ho, I. K. The assessment of tolerance to and physical dependence on
pentobarbital by multiple pellet implantation. Eur. J. Pharmacol. 65: 355-363, 1980.
81.
Flint, B. A. and Ho, I. K. Tolerance development to phencyclidine by chronic administration.
Progress in Neuro-Psychopharmacology 4: 233-239, 1980.
82.
Fujimori, K., Ho, I. K. and Mehendale, H. M. Assessment of photomirex toxicity in the mouse. J.
Toxicol. Environ. Health 6: 869-876, 1980.
83.
Flint, B. A. and Ho, I. K. Development of cross-tolerance between barbiturates and phencyclidine.
Substance and Alcohol Actions/Misuse 1: 287-293, 1980.
84.
Siraj, M. Y., Hayes, A. W., Takanaka, A. and Ho, I. K. Effects of patulin on hepatic
monooxygenase in male mice. J. Environ. Pathol. Toxicol. 4: 545-553, 1980.
85.
Ho, I. K., Fujimori, K., Huang, T. P. and Chang-Tusi, H. Neurochemical evaluation of chlordecone
toxicity in the mouse. J. Toxicol. Environ. Health 8: 701-706, 1981.
86.
Wang, T. P. H., Ho, I. K. and Mehendale, H. M. Correlation between neurotoxicity and
chlordecone levels in brain and plasma in the mouse. Neurotoxicology, 2: 373-381, 1981.
14
87.
Ho, I. K., Onoda, K. I. and Flint, B. A. Effects of chronic administration of phencyclidine on hepatic
mixed-function oxidases in the mouse. Biochem. Pharmacol. 30: 545-547, 1981.
88.
Nabeshima, T. and Ho, I. K. Pharmacologic response of pentobarbital in different strains of mice.
J. Pharmacol. Exp. Ther. 216: 198-204, 1981.
89.
Angevine, L. S., Nabeshima, T., Ho, I. K. and Mehendale, H. M. Effect of chlorphentermine on
the pulmonary disposition of norepinephrine in the isolated perfused rabbit lung. Exp. Lung
Res. 2: 71-84, 1981.
90.
Tai, C. Y., Nabeshima, T., Sivam, S. P. and Ho, I. K. Effects of acute and continuous
administrations of pentobarbital on phencyclidine response. Res. Comm. Subs. Abuse 2:
239-252, 1981.
91.
Nabeshima, T., Fontenot, J. and Ho, I. K. Effects of chronic administration of pentobarbital or
morphine on the cerebral cytochrome P-450 systems. Biochem. Pharmacol. 30: 1142-1145,
1981.
92.
Nabeshima, T. and Ho, I. K. Acute and chronic effect of pentobarbital on 5-hydroxytryptamine in
mouse brain. Progress in Neuropsychopharmacology 5: 373-381, 1981.
93.
Nabeshima, T., Fujimori, K. and Ho, I. K. Effects of acute or chronic pentobarbital administration
on the steady state level and the turnover rates of catecholamines in discrete brain areas of
mice. Progress in Neuropsychopharmacology 5: 121-128, 1981.
94.
Nabeshima, T., Sivam, S. P., Norris, J. C. and Ho, I. K. Calcium-dependent GABA release from
mouse brain slices following acute and chronic phencyclidine administration. Res. Comm. in
Substances of Abuse. 2: 343-354, 1981.
95.
Fontenot, J., Ho, I. K. and Nabeshima, T. Effect of pentobarbital administration on protein
synthesis in the brain. Substance and Alcohol Actions/Misuse 2: 249-258, 1981.
96.
Sivam, S. P., Nabeshima, T. and Ho, I. K. Alterations of regional GABA receptors in morphine
tolerant mice. Biochem. Pharmacol. 30: 2187-2190, 1981.
97.
Nabeshima, T., Ho, I. K. and Reese, C. M. Calcium-dependent GABA release from brain slices of
morphinized mice. Res. Comm. Subs. Abuse 3: 11-20, 1982.
98.
Hoskins, B. and Ho, I. K. Chlordecone-induced alterations in content and subcellular distribution of
calcium in mouse brain. J. Toxicol. Environ. Health 9: 535-544, 1982.
99.
Sivam, S. P., Nabeshima, T. and Ho, I. K. Acute and chronic effects of pentobarbital in relation to
postsynaptic GABA receptors: a study with muscimol. J. Neuroscience Res. 7: 37-47, 1982.
100.
Sivam, S. P. and Ho, I. K. Influence of morphine dependence on GABA stimulated
benzodiazepine binding to mouse brain synaptic membranes. Eur. J. Pharmacol. 79: 335336, 1982.
101.
Ritchie, G. P., Hume, A. S. and Ho, I. K. Evaluation of the possible development of crosstolerance between ethanol and pentobarbital in the mouse. Res. Comm. Subs. Abuse 3: 195209, 1982.
102.
Nabeshima T., Kameyama, T., Fontenot, J. and Ho, I. K. Effect of acute or chronic pentobartial
administration on incorporation of [3H]-leucine into protein fraction in mouse brain.
Neurosciences (Kobe, 1975) 8: 130-131, 1982.
15
103.
Sivam, S. P., Nabeshima, T. and Ho, I. K. Alterations of synaptic high and low affinity opiate
binding sites after acute and chronic morphine administration in mice. Prog.
Neuropsychopharmacol. 6: 119-127, 1982.
104.
Nabeshima, T., Sivam, S. P., Tai, C. Y. and Ho, I. K. Development of dispositional tolerance to
phencyclidine by osmotic minipump in the mouse. J. Pharmacol. Methods 7: 239-253, 1982.
105.
Fujimori, K., Nabeshima, T., Ho, I. K. and Mehendale, H. M. Effects of oral administration of
chlordecone and mirex on brain biogenic amines in mice. Neurotoxicology 3: 143-148, 1982.
106.
Sivam, S. P., Nabeshima, T. and Ho, I. K. An analysis of GABA receptor changes in the discrete
regions of mouse brain after acute and chronic treatments of morphine. J. Neurochem. 39:
933-939, 1982.
107.
Fujimori, K., Benet, H., Mehendale, H. M. and Ho, I. K. Comparison of brain discrete area
distributions of chlordecone and mirex in the mouse. Neurotoxicology 3: 125-130, 1982.
108.
Nabeshima, T. and Ho, I. K. Calcium-dependent GABA release from mouse brain slices following
acute and chronic pentobarbital administration and during withdrawal. Res. Comm. Subs.
Abuse 3: 483-497, 1982.
109.
Ritchie, G. P. and Ho, I. K. Effects of chlordecone and mirex on protein synthesis in mouse brain
and liver. Neurotoxicology 3: 243-248, 1982.
110.
Norris, J. C., Nabeshima, T. and Ho, I. K. Effects of phencyclidine on -aminobutyric acid
receptors in the mouse. Res. Comm. Subs. Abuse 3: 409-420, 1982.
111.
Sivam, S. P., Norris, J. C., Lim, D. K., Hoskins, B. and Ho, I. K. Influence of acute and chronic
cholinesterase inhibition with diisopropylfluorophosphate on muscarinic, dopamine and GABA
receptors of the rat striatum. J. Neurochem. 40: 1414-1422, 1983.
112.
Nabeshima, T., Sivam, S. P. and Ho, I. K. Effect of morphine on the responses to and disposition
of phencyclidine in mice. I. Enhancement of phencyclidine effects by acute morphine
administration. J. Pharmacol. Exp. Ther. 225: 325-331, 1983.
113.
Fujimori, K., Ho, I. K., Mehendale, H. M. and Villeneuve, D. C. Comparative toxicity of mirex,
photomirex and chlordecone after oral administration to the mouse. Environ. Tox. Chem. 2:
49-60, 1983.
114.
Lim, D. K., Hoskins, B. and Ho, I. K. Assessment of diisopropylfluorophosphate (DFP) toxicity and
tolerance in rats. Res. Comm. Chem. Pathol. Pharmacol. 39: 399-418, 1983.
115.
Ho, I. K. and Hoskins, B. Variation of commercial diisopropylfluorophosphate preparations in
neurotoxicological studies. Drug Chemical Toxicology 6: 421-427, 1983.
116.
Sivam, S. P. and Ho, I. K. GABAergic drugs, morphine and morphine tolerance: a study in
relation to nociception and gastrointestinal transit in mice. Neuropharmacology 22: 767-774,
1983.
117.
Fontenot, H. J., Wilson, R. D., Nabeshima, T., Yamamoto, I., Loh, H. H. and Ho, I. K. Dose
response of DNA and RNA synthesis to pentobarbital. Res. Comm. Subs. Abuse 4: 164-176,
1983.
118.
Sivam, S. P., Nabeshima, T., Lim, D. K., Hoskins, B. and Ho, I. K. Diisopropylfluorophosphate and
GABA synaptic function: effect on levels, enzymes, release and uptake in the rat striatum.
Res. Comm. Chem. Pathol. Pharm. 42: 51-60, 1983.
16
119.
Sivam, S. P., Hoskins, B. and Ho, I. K. An assessment of comparative acute toxicity of
diisopropyl- fluorophosphate, Tabun, Sarin and Soman in relation to cholinergic and
GABAergic enzyme activities in rats. Fundam. Appl. Toxicol. 4: 531-538, 1984.
120.
Sivam, S. P. and Ho, I. K. Antinociceptive and gastrointestinal effects of opiates: an analysis of
the nature of the involvement of mu and delta receptors of the central nervous system.
Neuropharmacology 23: 105-108, 1984
121.
Fernando, J. C. R., Hoskins, B. and Ho, I. K. A striatal serotonergic involvement in the behavioral
effects of anticholinesterase organophosphates. Eur. J. Pharmacol. 98: 129-132, 1984.
122.
Nabeshima, T., Sivam, S. P. and Ho, I.K. Attenuation of pharmacological effects and increased
metabolism of phencyclidine in morphine tolerant mice. Eur. J. Pharmacol. 104: 211-221,
1984.
123.
Berndt, W. O., Baggett, J., Hoskins, B., Lim, D. K. and Ho, I. K. Effects of
diisopropylfluorophosphate (DFP) on renal function in the rat. Toxicology 31: 223-235, 1984.
124.
Sivam, S. P. and Ho, I. K. Analgesic cross-tolerance between morphine and opioid peptides.
Psychopharmacology 84: 64-65, 1984.
125.
Fernando, J. C. R., Hoskins, B. and Ho, I. K. Effect on striatal dopamine metabolism and
differential motor behavioral tolerance following chronic cholinesterase inhibition with
diisopropylfluorophosphate. Pharmacol. Biochem. Behav. 20: 951-957, 1984.
126.
Nabeshima, T., Amano, M., Furukawa, H., Ho, I. K. and Kameyama, T. Design of a phencyclidine
implantation pellet: suitable for tolerance development. J. Pharmacol. Dyn. 7: 51-58, 1984.
127.
Ho, I. K., Fernando, J. C. R., Sivam, S. P. and Hoskins, B. Roles of dopamine and GABA in
neurotoxicity of organophosphorus cholinesterase inhibitors. Proc. Western Pharmacol. Soc.
27: 177-180, 1984.
128.
Purser, C., Baltar, A., Ho, I. K. and Hume, A. S. New rapid method of analysis of cefoxitin in
serum and bone, by high-performance liquid chromatography. J. Chromatography 311: 135140, 1984.
129.
Hoskins, B. and Ho, I. K. Effects of acute administration of and tolerance development to
morphine on the striatal calmodulin systems in mice of different ages. Neuropeptides 5: 6154, 1984.
130.
Benet, H., Fujimori, K. and Ho, I. K. The basal ganglia in chlordecone-induced neurotoxicity in the
mouse. Neurotoxicology 6: 151-158, 1985.
131.
Fernando, J. C. R., Lim, D. K., Hoskins, B. and Ho, I. K. Studies of behavioral tolerance to the
toxicity of the anticholinesterase organophosphates, Soman and Sarin. Res. Comm. Chem.
Path. Pharmacol. 48: 415-430, 1985.
132.
Sivam, S. P. and Ho, I. K. GABA in morphine analgesia and tolerance. Life Sci. 37: 199-208,
1985.
133.
Hoskins, B., Ho, I. K. and Meydrech, E. F. Effects of morphine and aging on running behavior and
brain calmodulin levels in mice. Experimental Aging Research. 11: 143-145, 1985.
134.
Hoskins, B., Ho, I. K. and Meydrech, E. F. Effects of aging and morphine administration on
calmodulin and calmodulin-regulated enzymes in striata of mice. J. Neurochem. 44: 10691073, 1985.
17
135.
Dulaney, M. D., Hoskins, B. and Ho, I. K. Studies on low dose sub-acute administration of soman,
sarin and tabun in the rat. Acta Pharmacol. et Toxicol. 57: 234-241, 1985.
136.
Fernando, J. C. R, Hoskins, B. and Ho, I. K. Rapid induction of supersensitivity to muscarinic
antagonists-induced motor excitation by continuous stimulation of cholinergic receptors. Life
Sci. 37: 883-892, 1985.
137.
Yamamoto, I., Kimura, T., Takeoka, Y., Watanabe, K., and Ho, I. K. N3-Benzyluridine exerts
hypnotic activity in mice. Chem. Pharm. Bull. 33: 4088-4090, 1985.
138.
Yamamoto, I., Tateoka, Y., Watanabe, K., Nabeshima, T., Fontenot, H. J. and Ho, I. K. The
prolonging effects of N,N'-diallylpentobarbital on drug induced sleep and motor incoordination.
Res. Comm. Chem. Pathol. Pharmacol. 50: 209-220, 1985.
139.
Hoskins, B., Burton, C. K., Lieu, D. D., Porter, A. B. and Ho, I.K. Regional and subcellular
calmodulin content of rat brain. J. Neurochem. 46: 303-304, 1986.
140.
Hoskins, B., Liu, D. D. and Ho, I. K. Acute effects of Soman, Sarin and Tabun on microsomal and
cytosolic components of the calmodulin system in rat striatum. J. Neurochem. 46: 265-269,
1986.
141.
Moore, S. J., Norris, J. C., Ho, I. K. and Hume, A. S. The efficacy of -ketoglutaric acid in the
antagonism of cyanide intoxication. Toxicol. Appl. Pharmacol. 82: 40-44, 1986.
142.
Hoskins, B., Fernando, J. C. R., Dulaney, M. D., Lim, D. K., Liu, D. D., Watanabe, H. K. and Ho, I.
K. Relationship between the neurotoxicities of soman, sarin and tabun, and
acetylcholinesterase inhibition. Toxicology Letters 30: 121-129, 1986.
143.
Lim, D. D., Hoskins, B. and Ho, I. K. Correlation of muscarinic receptor density and
acetylcholinesterase activity in repeated DFP treated rats after the termination of DFP
administration. Eur. J. Pharmacol. 123: 223-228, 1986.
144.
Watanabe, H. K., Hoskins, B. and Ho, I. K. Selective inhibitory effect of organophosphates on
UDP-glucuronyltransferase activities in rat liver microsomes. Biochem. Pharmacol. 35: 455460, 1986.
145.
Fernando, J. C. R., Hoskins, B. and Ho, I. K. Hypersensitivity to antimuscarinic agents following
brief exposure to the cholinesterase inhibitors Soman and Sarin. J. Toxicol. Environ. Health
18: 103-109, 1986.
146.
Hoskins, B. and Ho, I. K. Lack of effect of dynorphin on consummatory behaviors in obese and
normal rats. Life Sci. 39: 589-593, 1986.
147.
Tateoka, Y., Yamamoto, I., Watanabe, K. and Ho, I. K. N,N'-Diallylbarbital potentiation of druginduced sleep and motor incoordination. Res. Comm. Chem. Pathol. Pharmacol. 52: 17-28,
1986.
148.
Rao, K.S.P., Fernando, J.C.R., Ho, I. K. and Mehendale, H. M. Neurotoxicity in rats following
subchronic amiodarone treatment. Res. Comm. Chem. Pathol. Pharmacol. 52: 217-224,
1986.
149.
Liu, D. D., Ho, I. K. and Hoskins, B. Acute effects of Soman, Sarin and Tabun on cyclic
nucleotide metabolism in rat striatum. J. Toxicol. Env. Health. 19: 23-32, 1986.
150.
Hoskins, B., Burton, C. K. and Ho, I. K. Morphine-induced analgesia and motor activity in mature
adult and aged mice. Pharmacol. Biochem. Behav. 25: 599-605, 1986.
18
151.
Fernando, J. C. R., Hoskins, B. and Ho, I. K. The role of dopamine in behavioral supersensitivity
to muscarinic antagonists following cholinesterase inhibition. Life Sci. 39: 2169-2176, 1986.
152.
Yamamoto, I., Kimura, T., Tateoka, Y., Watanabe, K. and Ho, I. K. Central depressant activities of
N3-allyluridine and N3-allylthymidine. Res. Comm. Chem. Pathol. Pharmacol. 52: 321-332,
1986.
153.
Hoskins, B. and Ho, I. K. Effects of maturation and aging on calmodulin and calmodulin-regulated
enzymes in various regions of mouse brain. Mechanisms of Ageing and Development 36:
173-186, 1986.
154.
Yamamoto, I., Tateoka, Y., Kimura, T., Yamazaki, F., Hamajima, K., Watanabe, K., and Ho, I. K.
Central effects of N-allyl,N'-methylbarbital and N-allylmethyprylon in mice. Res. Comm.
Chem. Pathol. Pharmacol. 54: 191-199, 1986.
155.
Fujimori, K., Benet, H., Mehendale, H. M. and Ho, I. K. In vivo and in vitro synthesis, release and
uptake of 3H-dopamine in mouse striatal slices after in vivo exposure of chlordecone. J.
Biochem. Toxicol. 1: 1-12, 1986.
156.
Lim, D. K., Fernando, J. C. R., Hoskins, B. and Ho, I. K. Quantitative assessment of tolerance
development to diisopropylfluorophosphate. Pharmacol. Biochem. Behav. 26: 281-286, 1987.
157.
Yamamoto, I., Tateoka, Y., Watanabe, K. and Ho, I. K. N,N'-Diallylpentobarbital: antagonism of
barbital in mice and rats. Life Sci. 40: 1439-1442, 1987.
158.
Takeoka, Y., Kimura, T., Watanabe, K., Yamamoto, I. and Ho, I. K. Potentiation of barbiturateinduced narcosis by N,N'-(or N,S-)-diallyl-substituted derivatives of phenobarbital, amobarbital
and thiopental in mice. Chem. Pharm. Bull. 35: 778-784, 1987.
159.
Watanabe, H.K., Hoskins, B. and Ho, I. K. Sensitivity difference to hepatotoxicity of cocaine in
SHR and WKY rats. Alcohol Drug Research 7: 363-370, 1987.
160.
Lim, D. K., Hoskins, B. and Ho, I. K. Evidence for the involvement of presynaptic cholinergic
functions in tolerance to DFP. Toxicol. Appl. Pharmacol. 90: 465-476, 1987.
161.
Lim, D. K., Porter, A. C., Hoskins, B. and Ho, I. K. Changes in ACh levels in the rat brain during
subacute administration of diisopropylfluorophosphate (DFP). Toxicol. Appl. Pharmacol. 90:
477-489, 1987.
162.
Watanabe, H. K., Hoskins, B. and Ho, I. K. Effects of cold stress on brain regional calcium
content in rats and mice. Brain Res. Bulletin. 19: 407-409, 1987.
163.
Nabeshima, T., Sivam, S. P. and Ho, I. K. Influence of morphine addiction on hepatic microsomal
functions of mouse. Res. Comm. Subs. Abuse. 8: 77-84, 1987.
164.
Hoskins, B. and Ho, I. K. Age-induced differentiation of morphine's effect on cyclic nucleotide
metabolism. Neurobiology of Aging 8: 473-476, 1987.
165.
Yamamoto, I., Kimura, T., Tateoka, Y., Watanabe, K. and Ho, I. K. Hypnotic activity of N3benzylthymidine on mice. Life Sci. 41: 2791-2797, 1987.
166.
Tateoka, Y., Kimura, T., Watanabe, K., Yamamoto, I. and Ho, I. K. Mechanism of N, N'diallylpentobarbital potentiation of pentobarbital-induced sleep in mice. Res. Comm. Chem.
Pathol. Pharmacol. 57: 173-185, 1987.
19
167.
Yamamoto, I., Kimura, T., Takeoka, Y., Watanabe, K. and Ho, I. K. N-Substituted oxopyrimidines
and nucleosides: structure-activity relationship for hypnotic activity as central nervous system
depressent. J. Med. Chem. 30: 2227-2231, 1987.
168.
Liu, D. D., Ueno, E., Ho, I. K. and Hoskins, B. Evidence that changes in levels of cyclic nucleotides in the CNS are not related to soman-induced convulsions. Neurotoxicology 9: 23-38,
1988.
169.
Watanabe, H. K., Hoskins, B. and Ho, I. K. Effects of subacute treatment with cocaine on activity
of N-demethylase, UDP-glucuronyltransferase and sulfotransferase in WKY and SHR rat
liver-sex and strain differences. Life. Sci. 42: 79-86, 1988.
170.
Ito, Y., Lim, D. K., Hoskins, B. and Ho, I. K. Bicuculline up-regulation of GABAA receptors in rat
brain. J. Neurochem. 51: 145-152, 1988.
171.
Ueno, E., Liu, D. D., Ho, I. K. and Hoskins, B. Opiate receptor characteristics in brains from
young, mature and aged mice. Neurobiology of Aging 9: 279-283, 1988.
172.
Liu, D. D., Ueno, E., Ho, I. K. and Hoskins, B. Evidence that alterations in GABA and ACh in rat
striata and cerebella are not related to soman-induced convulsions. J. Neurochem. 51: 181187, 1988.
173.
Hoskins, B., Burton, C. K. and Ho, I. K. Diabetes potentiation of cocaine toxicity. Res. Comm.
Sub. Abuse 9: 117-123, 1988.
174.
Lim, D. K., Ito, Y., Hoskins, B. and Ho, I. K. Effects of acute and subacute administration of bicuculline on dopamine and muscarinic receptors in rat brain. Brain Res. Bull. 21: 21-24, 1988.
175.
Ito, Y., Hoskins, B. and Ho, I. K. Cerebellar GABAA and benzodiazepine receptor characteristics
in young and aged mice. Brain Res. Bull. 21: 251-255, 1988.
176.
Takeoka, Y., Kimura, T., Kamiyama, H., Watanabe, K., Yamamoto, I. and Ho, I. K. Central
effects of N-substituted derivatives of 2,6-dioxopiperidine in mice. Res. Comm. Chem.
Pathol. Pharmacol. 61: 315-326, 1988.
177.
Ishizuka, Y., Rockhold, R. W., Hoskins, B. and Ho, I. K. Cocaine-induced changes in 3H-naloxone
binding in brain membranes isolated from spontaneously hypertensive and Wister-Kyoto rats.
Life Sci. 43: 2275-2282, 1988.
178.
Lim, D. K., Ito, Y., Stewart, T., Hoskins, B. and Ho, I. K. Toxicity study of continuous
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179.
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291.
Oh, S., Wellman, S. E. and Ho, I. K. Changes in [3H]forskolin binding to adenylate cyclase and
[3H]phorbol dibutyrate binding to protein kinase C in pentobarbital tolerant/dependent rats.
Neurochem. Res. 23: 463-467, 1998.
292.
Wongchanapai, W., Tsang, B. K., He, Z. and Ho, I. K. Relative involvement of spinal opioid
receptors in physical dependence on intrathecal butorphanol and morphine. Pharmacol.
Biochem Behav. 60: 899-907, 1998.
27
293. Zhu, H. and Ho, I. K. NMDA-R1 Antisense oligonucleotide attenuates withdrawal signs from
morphine. Europ. J. Pharmacol. 352: 151-156, 1998.
294. Draminski, M. Turski, K., Tateoka, Y, Kimura, T., Watanabe, K., Kondo, S., Ho, I. K. and
Yamamoto, I. Synthesis and sedative-hypnotic effects of N3-allyl- and N1-allyl-5,6-substituted
2-thiouracil derivatives in mice. Chem. Pharm. Bull. 46: 1370-1373, 1998.
295. Yamamoto, I., Kimura, T., Kamei, A. Yoshida, H., Watanabe, K., Ho, I. K. and Yoshimura, H.
Competitive inhibition of 8-tetrahydrocannabinol and its active metabolites for cannabinoid
receptor binding. Biol. Pharm. Bull. 21: 408-410, 1998.
296. Suzuki, T., Ito, T., Wellman, S. and Ho, I. K. Autoradiographic study of [3H]flunitrazepam binding
sites in the subnuclei of the thalamus of rats rendered tolerant to and dependent on
pentobarbital. Europ. J. Pharmacol., 354: 145-151, 1998.
297. Jang, C.-G., Oh, S. and Ho, I. K. Changes in NMDAR2 subunit mRNA levels during pentobarbital
tolerance/withdrawal in the rat brain: an in situ hybridization study. Neurochem. Res. 23:
1371-1377, 1998.
298. Wongchanapai, W., Tsang, B. K., He, Z., Ma, T. and Ho, I. K. Supersensitivity of spinal opioid
receptors to antagonists in intrathecal butorphanol and morphine dependence. Life Sci. 63:
2175-2180, 1998.
299. Oh, S., Jang, C.-G. and Ho, I. K. Activation of protein kinase C by phorbol dibutyrate potentiates
[3H]MK-801 binding in rat brain slices. Brain Res. 793: 337-340, 1998.
300. Chen, H.-H., Ma, T. G. and Ho, I. K. Protein kinase C in rat brain is altered by developmental lead
exposure. Neurochem. Res. 24: 415-421, 1999.
301. Zhu, H., Jang, C.-G., Ma, T., Oh, S., Rockhold, R. W. and Ho, I. K. Region specific expression of
NMDA receptor NR1 subunit mRNA in hypothalamus and pons following chronic morphine
treatment. Europ. J. Pharmacol. 365: 47-54, 1999.
302. Jang, C.-G., Rockhold, R. W. and Ho, I. K. Withdrawal from butorphanol dependence alters binding
of [3H]phorbol dibutyrate to protein kinase C, but not of [3H]forskolin to adenylate cyclase.
Brain Res. 821: 520-525, 1999.
303. Ma, T., Chen, H.-H. and Ho, I. K. Effects of chronic lead (Pb) exposure on neurobehavioral function
and dopaminergic neurotransmitter receptors in rats. Toxicol. Lett. 105: 111-121, 1999.
304. Jang, C.-G., Oh, S., Zhu, H. and Ho, I. K. Autoradiography of [3H]glutamate binding during
pentobarbital tolerance and withdrawal in the rats. Brain Res. Bull. 48: 99-102, 1999.
305. Wongchanapai, W., Tsang, B.K. & Ho, I.K. The -opioid receptor in opioid dependence. J Food
Drug Anal. 7: 1-12, 1999.
306. Liu, N., Rockhold, R. W. and Ho, I. K. Electrical stimulation of nucleus paragigantocellularis induces
opioid withdrawal-like behaviors in the rat. Pharmacol. Biochem. Behav. 62: 263-271, 1999.
307. Liu, N., Ho, I. K. and Rockhold, R. W. Contribution of glutamatergic systems in locus coeruleus to
nucleus paragigantocellularis stimulation-evoked behavior. Pharmacol. Biochem. Behav. 63:
555-567, 1999.
308. Yao, C. S., Kimura, T., Watanabe, K., Kondo, S., Ho, I. K. and Yamamoto, I. Synthesis and central
nervous system depressant effects of N3-substituted 2’,3’-O-isopropylideneuridines. Chem.
Pharm. Bull. 47: 1802-1804, 1999.
28
309. Oh, S. and Ho, I. K. Changes of [3H]muscimol binding and GABA 2-subunit mRNA in rats
rendered tolerant to and dependent on pentobarbital. Neurochem. Res. 24: 1603-1609, 1999.
310. Oh, S., Jang, C.-G., Ma, T. and Ho, I. K. Activation of protein kinase C by phorbol dibutyrate
modulates GABAA receptor binding in rat brain slices. Brain Res. 850: 158-165, 1999.
311. Jang, C.-G., Park, Y., Rockhold, R. W. and Ho, I. K. Autoradiographic study of NMDA-displaceable
[3H]-glutamate and [3H]-MK-801 binding during butorphanol withdrawal in the rat brain. Brain
Res. 845: 236-241, 1999.
312. Tokuyama, S., Ma, T., Ho, I. K. and Yamamoto, T. Autoradiographic analysis of [3H]MK-801 binding
in brains of morphine- or butorphanol-withdrawn rats. Res. Commun. Alcohol Subs. Abuse 20:
81-89, 1999.
313. Rockhold, R. W., Zhu, H., Liu, N. and Ho, I. K. The nucleus paragigantocellularis and opioid
withdrawal-like behavior. J. Biomed. Sci. 7:270-276, 2000.
314. Tokuyama, S., Ho, I. K. and Yamamoto, T. A protein kinase inhibitor, H-7, blocks naloxoneprecipitated changes in dopamine and its metabolites in the brains of opioid-dependent rats.
Brain Res. Bull. 52: 363-369, 2000.
315. Jang, C.-G. and Ho, I. K. N-methyl D-aspartate receptor NR1 subunit mRNA level was decreased
in rat brain during pentobarbital withdrawal. Neurosci. Lett. 282: 129-132, 2000.
316. Park, Y., Jang, C.-G., Ho, I. K. and Ko, K. H. Kappa-opioid agonist stimulated regional distribution
of [35S]GTPS binding in butorphanol continuously infused rat. Brain Res. Bull. 52: 17-20, 2000.
317. Jang, C.-G., Rockhold, R. W. and Ho, I. K. An autoradiographic study of [3H]AMPA receptor binding
and in situ hybridization of AMPA sensitive glutamate receptor A (GluR-A) subunits following
morphine withdrawal in the rat brain. Brain Res. Bull. 52: 217-221, 2000.
318. Park, Y., Ma, T., Tanaka, S., Jang, C.-G., Loh, H. H., Ko, K. H. and Ho, I. K. Comparison of Gprotein activation in the brain by -, -, and -opioid receptor agonists in -opioid receptor
knockout mice. Brain Res. Bull. 52: 297-302, 2000.
319. Jang, C.-G., Park, Y., Tanaka, S., Ma, T., Loh, H. H. and Ho, I. K. Involvement of -opioid receptors
in potentiation of apomorphine-induced climbing behavior by morphine: studies using -opioid
receptor gene knockout mice. Mol. Brain Res. 78: 204-206, 2000.
320. Kimura, T., Miki, M., Watanabe, K., Kondo, S., Ho, I. K. and Yamamoto, I. Metabolism of a novel
hypnotic, N3-phenacyluridine, and hypnotic and sedative activities of its enantiomer metabolites
in mice. Xenobiotica, 30: 643-653, 2000.
321. Kimura, T., Yao, S., Watanabe, K., Kondo, S., Ho, I. K., and Yamamoto, I. Hypnotic action of N3substituted abrabinofuranosyluracils on mice. Chem. Pharm. Bull. 49: 111-113, 2001.
322. Kimura, T. Miki, M., Ikeda, M., Ynemoto, S., Watanabe, K., Kondo, S., Ho, I. K. and Yamamoto, I.
Possible existence of a novel receptor for uridine analogues in the central nervous system using
two isomers, N3-(S)-(+) and N3-(R)-(-)--hydroxy--phenethyluridines. Biol. Pharm. Bull. 24(6):
727-731, 2001.
323. Park, Y., Jang, C.-G., Tanaka, S., Ma, T., Loh, H. H., Ho, I. K. and Ko, K. H. Effects of morphine on
pentobarbital-induced responses in -opioid receptor knockout mice. Brain Res. Bull. 54: 527531, 2001.
29
324. Park, Y., Ho, I. K., Fan, L.-W., Loh, H. H, and Ko, K. H.. Region specific increase of dopamine
receptor D1/D2 mRNA expression in the brain of -opioid receptor knockout mice. Brain Res.
894: 311-315, 2001.
325. Kimura, T., Ho, I. K. and Yamamoto, T. Uridine receptor: Discovery and its involvement in the sleep
mechanism. Sleep 24: 251-260, 2001.
326. Jang, C.-G., Lee, S.-Y., Loh, H. H. and Ho, I. K.. Lack of -opioid receptor gene leads to an
increase in the NMDA receptor subunit mRNA expression and NMDA-induced convulsion.
Molec. Brain Res. 94: 105-111, 2001.
327. Jang, C.-G., Lee, S.-Y., Park, Y., Ma, T., Loh, H. H. and Ho, I. K. Differential effects of morphine,
DPDPE, and U-50488 on apomorphine-induced climbing behavior in -opioid receptor knockout
mice. Molec. Brain Res. 94: 197-199, 2001.
328. Ma, T., Cai, Z., Wellman, S. and Ho, I. K.. A quantitative histochemistry technique for measuring
regional distribution of acetylcholinesterase in the brain using digital scanning densitometry.
Analyt. Biochem. 296: 18-28, 2001.
329. Tokuyama, S., Zhu, H., Oh, S. Ho, I. K. and Yamamoto, T. Further evidence for a role of NMDA
receptors in the locus coeruleus in the expression of withdrawal syndrome from opioids.
Neurochem. 39: 103-109, 2001.
330. Chen, H., Ma, T. and Ho, I. K. Effects of developmental lead exposure on inhibitory avoidance
learning and glutamate receptors in rats. Environ. Toxicol. Pharmacol. 9: 185-191, 2001.
331. Oh, S., Kim, Y. H., Hann, H. J., Lee, H. L., Choi, H. S., Kim, H. S. and Ho, I. K. Modulation of the
levels of NMDA receptor subunit mRNA and the bindings of [3H’MK801 in rat brain by chronic
infusion of subtoxic dose of MK-801. Neurochem. Res. 26: 559-565, 2001.
332. Zhu, H., Rockhold, R. W., Baker, R. C., Kramer, R. E. and Ho, I. K. Effects of single or repeated
dermal exposure to methyl parathion on behavior and blood cholinesterase activity in rats. J.
Biomed. Sci. 8: 467-474, 2001.
333. Sasaki, K., Fan, L.-W., Tien, L.-T., Ma, T., Loh, H. H. and Ho, I. K. The interaction of morphine and
GABAergic systems in anxiolytic behavior: using mu-opioid receptor knockout mice. Brain Res.
Bull. 57: 689-694, 2002.
334. Fan, L.-W., Tanaka, S., Tein, L.-T., Ma, T., Rockhold, R.W. and Ho, I. K. Withdrawal from
dependence upon butorphanol uniquely increases 1-opioid receptor binding in the rat brain.
Brain Res. Bull. 58: 149-160, 2002.
335. Kramer, R. E. and Ho, I. K. Pharmacokinetics and pharmacodynamics of methyl parathion. Chin.
Med. J. 65: 187-199, 2002.
336. Fan, L.-W., Tanaka, S., Park, Y., Sasaki, K., Ma, T., Tien, L.-T., Rockhold, R.W. and Ho, I.K.
Butorphanol dependence and withdrawal decrease hippocampal 2-opioid receptor binding.
Brain Res. 958: 277-290, 2002.
337. Sinchaisuk, S., Ho, I. K. and Rockhold, R. W. Focal -opioid receptor-mediated dependence and
withdrawal in the nucleus paragigantocellularis. Pharmacol. Biochem. Behav. 74: 241-252,
2002.
338. Zhu, H., Ho, I.K., Kramer, R.K., Baker, R.C. and Rockhold, R.W. Methyl parathion masks
withdrawal from physical dependence on morphine. Intl. J. Molecular Sci. 3: 1073-1081, 2002.
30
339. Fan, L.-W., Rockhold. R.W. and Ho, I.K. -Opioid receptors in physical dependence upon
butorphanol. J. Med. Sci. 23: 1-18, 2003.
340. Ma, T., Kramer, R.E., Baker, R.C., Fan, L.-W. and Ho, I.K. Effects of chronic dermal exposure to
nonlethal doses of methyl parathion on brain regional acetylcholinesterase and muscarinic
cholinergic receptors in female rats. J. Neurosci. Res. 71: 138-145, 2003.
341. Fan, L.-W., Tien, L.-T., Tanaka, S., Sasaki, K., Park, Y., Ma, T., Rockhold, R.W. and Ho, I.K.
Enhanced binding of nor-binaltorphimine to -opioid receptors in rats dependent upon
butorphanol. J. Neurosci. Res. 72: 781-789, 2003.
342. Park, Y., Jang, C.-G., Yang, K.-H., Loh, H. H., Ma. T. and Ho, I. K. Regional specific increases of
[3H]AMPA binding and mRNA expression of AMPA receptors in the brain of -opioid receptor
knockout mice. Mol. Brain Res. 113: 116-123, 2003
343. Tien, L.-T., Park, Y., Fan, L.-W., Ma, T. Loh, H.H. and Ho, I.K. Increased dopamine D2 receptor
binding and enhanced apomorphine-induced locomotor activity in -opioid receptor knockout
mice. Brain Res. Bull. 61: 109-115, 2003.
344. Fan, L.-W., Tien, L.-T., Tanaka, S., Ma, T., Chudapongse, N., Sinchaisuk, S., Rockhold, R.W. and
Ho, I.K. Changes in the brain -opioid receptor levels of rats in withdrawal from physical
dependence upon butorphanol. Neurosci. 121: 1063-1074, 2003.
345. Chudapongse, N., Kim, S., Sasaki, K.,. Kramer, R.E and Ho, I. K.. Nonopioid receptor-mediated
effects of U-50,488H on [Ca2+]i and extracellular dopamine in PC12 cells. J Neurosci. Res. 74:
598-604, 2003.
346. Chudapongse, N., Kim, S., Kramer, R.E. and Ho, I.K. Nonspecific effects of U-50,488H, a -opioid
agonist, on dopamine uptake and release in PC12 cells. J. Pharmacol. Sci. 93: 372-375, 2003.
347. Sun, T., Ma, T. and Ho, I.K. Differential modulation of muscarinic receptors in the rat brain by
repeated exposure to methyl parathion. J. Toxicol. Sci. 28: 427-438, 2003.
348. Tien, L.T., Fan, L.W., Sogawa, C., Ma, T., Loh, H.H. and Ho, I.K. Changes in acetylcholinesterase
activity and muscarinic receptor bindings in -opioid receptor knockout mice. Mol. Brain Res.
126: 38-44, 2004
349. Yoo, J.-H., Lee, S.-Y., Loh, H.H., Ho, I.K. and Jang, C-G. Loss of nicotine-induced behavioral
sensitization in -opioid receptor knockout mice. Synapse 51: 219-223, 2004.
350. Tien, L.T., Fan, L.W., Ma, T., Loh, H.H. and Ho, I.K. Increased diisopropylfluorophosphate (DFP)induced toxicity in -opioid receptor knockout mice. J. Neurosci. Res. 78: 259-267, 2004.
351. Kim, S.-Y., Chudapongse, N., Lee, S.-M., Levin, M.C., Oh, J.-T., Park, H.-J. and Ho, I.K. Proteomic
analysis of phosphotyrosyl proteins in the rat brain: Effect of butorphanol dependence. J.
Neurosci. Res. 77: 867-877, 2004.
352. Yoo, J.-H., Lee, S.-Y., Loh, H.H., Ho, I.K. and Jang, C.-G. Altered emotional behaviors and the
expression of 5-HT1A and M1 muscarinic receptors in -opioid receptor knockout mice. Synapse
54: 72-82, 2004.
353. Zhu, H., Zhou, W., Li, X.R., Ma, T., Ho, I.K. and Rockhold, R.W. Methyl parathion increases
neuronal activities in the rat locus coeruleus. J. Biomed. Sci. 11: 732-738, 2004.
354. Ho, I.K., Fan, L.-W., Kim, S.-Y., Ma, T. and Rockhold, R.W. Neurochemical alterations in physical
dependence on butorphanol. J. Appl. Pharmacol. 12: 198-201, 2004.
31
355. Commiskey, S., Fan, L.-W., Ho, I.K. and Rockhold, R.W. Butorphanol: Effects of a prototypical
agonist-antagonist analgesic on -opioid receptors. J. Pharmacol. Sci. 98: 109-116, 2005.
356. Tien, L.-T., Fan, L.-W., Ma, T., Loh, H.H. and Ho, I.K. Roles of -opioid receptors in development of
tolerance to diisopropylfluorophosphate (DFP). J. Toxicol. Sci. 30: 43-59, 2005.
357. Chiu, C.-T., Ma, T. and Ho, I.K. Attenuation of methamphetamine-induced behavioral sensitization
in mice by systemic administration of nalrexone. Brain Res. Bull. 67: 100-109, 2005
358. Tanaka, S., Fan, L.-W., Tien, L.-T., Park, Y., Liu-Chen, L.-Y., Rockhold, R.W. and Ho, I.K.
Butorphanol dependence increases hippocampal -opioid receptor gene expression. J.
Neurosci. Res. 82: 255-263, 2005.
359. Oh, S., Chang, C.-Y., Baker, R.C. and Ho, I.K. Phorbol ester differentiates the levels of [3H]MK-801
binding in rat lines selected for differential sensitivity to the hypnotic effects of ethanol.
Neurochem. Res. 30: 161-169, 2005.
360. Kim, S.-Y., Chudapongse, N., Lee, S.M., Levin, M.C., Oh, J.T., Park H.J. and Ho, I.K. Proteomic
analysis of phosphotyrosyl proteins in morphine-dependent rat brains. Molec. Brain Res. 133:
58-70, 2005.
361. Sun, T.-T., Paul, I.A. and Ho, I.K. Motor functions but not learning and memory are impaired upon
repeated exposure to sub-lethal doses of methyl parathion. J. Biomed. Sci. 13: 515-523, 2006.
362. Chiu, C.-T., Ma, T. and Ho, I.K. Methamphetamine-induced behavioral sensitization in mice:
alterations in -opioid receptors. J. Biomed. Sci. 13:797-811, 2006.
363. Tien, L.T., Ma, T., Fan, L.W., Loh, H.H., Ho, I.K. Autoradiographic analysis of GABAA receptors in
-opioid receptor knockout mice. J. Neurosci. Res. 32:1891-1897, 2007.
363. Tien, L.T., Ho, I.K., Loh, H.H., Ma, T. Role of -opioid receptor in modulation of preproenkephalin
mRNA expression and ppioid and dopamine receptor binding in methamphetamine-sensitized
mice. J. Neurosci. Res. 85:673-680, 2007
364.
Lan, K.C., Ma, T., Lin-Shiau, S.Y., Liu, S.H. and Ho, I.K. Methamphetamine-elicited alterations of
dopamine- and serotonin-metabolite levels within -opioid receptor knockout mice: a
microdialysis study. J. Biomed. Sci. 15:391-403, 2008.
365.
Dai X., Brunson C.D., Rockhold R.W., Loh H.H., Ho I.K., Ma T. Gender differences in the
antinociceptive effect of tramadol, alone or in combination with gabapentin, in mice. J. Biomed.
Sci. Published online: 3 May 2008.
366.
Lan K.C., Chang A.C., Liu S.H., Ho I.K., Lin-Shiau S.Y. Enhancing effects of morphine on
methamphetamine-induced reinforcing behavior in association with dopamine metabolism in
mice. J. Neurochem. 109:382-392, 2009.
367.
Hwang L.L., Wan C.H., Li T.L., Chang S.D., Lin L.C., Chen C.P., Chen C.T., Liang K.C., Ho I.K.,
Yang W.S., Chiou L.C. Sex differences in high-fat diet-induced obesity, metabolic disorders,
and deficits of learning and hippocampal synaptic plasticity in mice. Obesity. 18:463-469, 2010.
368.
Wang S.C., Ho I.K., Wu S.L., Liu S.C., Kuo H.W., Lin K.N., Liu Y.L. Development of a method to
measure methadone enantiomers and its metabolites without enantiomer standard compounds
for the plasma of methadone maintenance patients. Biomedical Chromatography. In press.
32
369.
Tien, L.T., Ho, I.K., Ma, T. Methamphetamine-induced expression of zif268 mRNA is prevented
by haloperid in mice lacking -opioid receptor. NeuroToxicology. In press.
370.
Shen X., Purser C., Tien L.T., Chiu C.T., Paul I.A., Baker R., Loh H.H., Ho I.K., Ma T. -opioid
receptor knockout mice are insensitive to methamphetamine-induced behavioral sensitization. .
J. Neurosci. Res. In press.
371.
Tien, L.T., Ho, I.K. Involment of -opioid receptor in methamphetamine-indeuced behavioral
sensityztion. Current Neuropharmacolgy (submitted).
33
REVIEW ARTICLES, BOOK CHAPTERS, ETC.
1.
Way, E.L., Loh, H. H., Ho, I. K., Iwamoto, E. T. and Wei, E. Neuroanatomical and chemical
correlates of naloxone precipitated withdrawal. In: Advances in Biochemistry and
Psychopharmacology, Vol. 8, pp. 455-469, 1973.
2.
Way, E. Leong, Ho, I. K. and Loh, H. H. Relation of brain serotonin to the inhibition and
enhancement of morphine tolerance and physical dependence. In: Newer Concepts in
Neurotransmitter Regulation, ed. A. J. Mandell (Plenum Press, N. Y. -London) pp. 279-295,
1973.
3.
Ho, I. K. Assessment of biochemical mechanisms of drug tolerance and dependence.
Neurobiology Seminar, p. 27-28, sponsored by National Science Council, Republic of China with
the support of National Science Foundation, U.S.A. and the Asian Foundation in Taipei, Taiwan,
Sept. 4-6, 1973.
4.
Way, E. L., Ho, I.K. and Loh, H. H. Brain 5-hydroxytryptamine and cyclic AMP in morphine
tolerance and dependence. In: Adv. Biochem. Psychopharmacol., Vol. 40, ed. E. Costa, G. L.
Gessa and M. Sandler, Raven Press, N.Y., pp. 219-231, 1974.
5.
Ho, I. K., Loh, H. H. Bhargava, H. and Way, E. L. Effect of cyclic nucleotides and
phosphodiesterase inhibition on morphine tolerance and physical dependence. In: Opiate
Narcotics, Neurochemical Mechanisms in Analgesia and Dependence, ed. A. Goldstein,
Pergamon Press, pp. 143-148, 1975.
6.
Yamamoto, I., Ho, I. K. and Loh, H. H. Dispositional and Functional Tolerance to Barbiturates By Using the Pellet Implantation Method. Fourth Symposium on Drug Action, Nagasaki, Japan,
Oct. 30-31, 1975.
7.
Ho, I. K. Comment on Narcotics and Narcotic Antagonists, In Interactions of Drugs of Abuse, eds.
E. S. Vesell and M. C. Brande, Ann. N.Y. Acad. Sci. 281: 371, 1976.
8.
Ho, I. K. and Desaiah, D. Catecholamine sensitive ATPase in the central nervous system. In:
Catecholamines: Basic and Clinical Frontiers, ed. E. Usdin, I. J. Kopin and J. Barchas,
Pergamon Press, N.Y., pp. 532-534, 1979.
9.
Ho, I. K. Effects of acute and chronic administration of pentobarbital on GABA system. In:
Proceeding of International Symposium on GABA and other Inhibitory Neurotransmitters. Brain
Res. Bulletin 5: Suppl. 2 pp. 913-917, 1980.
10.
Ho, I. K. and R. A. Harris. Mechanisms of action of barbiturates. Ann. Rev. Pharmacol. Toxicol.,
Vol. 21, pp. 83-111, 1981.
11.
Nabeshima, T., Sivam, S. P., Kameyama, T. and Ho, I. K. Interaction between morphine and
phencyclidine: Intoxication and cross tolerance. In: Advances in Endogenous and Narcotic
Research Conference, pp. 338-340, Kodansha Ltd, Tokyo, 1981.
12.
Sivam, S. P., Nabeshima, T. and Ho, I. K. Involvement of GABA in the acute and chronic effects
of morphine: nociceptive, GABA release and receptor binding studies. In: Advances in
Endogenous and Exogenous Opioids. Proceedings of the International Narcotic Research
Conference, pp. 449-451. Kodansha Ltd, Tokyo, 1981.
34
13.
Ho, I. K., Nabeshima, T., Sivam, S. P., Flint, B. A. and Hoskins, B. Effects of pentobarbital on
GABA system. In: Advances in Neuropharmacology: Proceedings of the International Workshop
on Neuropharmacology, ed. C. Y. Lee. Academia Sinica, Taipei, Republic of China, pp. 133-140,
1981.
14.
Ho, I. K. and Hoskins, B. Biochemical methods for neurotoxicological analysis of neuroregulators
and cyclic nucleotides. In: Principles and Methods of Toxicology, ed. A. W. Hayes, Raven Press,
New York pp. 375-406, 1982.
15.
Nabeshima, T., Kameyama, T. and Ho, I.K. Mechanism of tolerance development to
phencyclidine in relation to GABAergic neuronal and dispositional functions in mice. In:
Proceedings of the 10th Symposium of Pharmacological Activity in Mechanism, Maebashi J.
Pharm. Dyn. 5, S-46, 1982.
16.
Ho, I. K. and Hoskins, B. Biochemical Methods for Neurotoxicological Analyses of
Neuroregulators and Cyclic Nucleotides. In: Principles and Methods of Toxicology, ed. A. W.
Hayes, Raven Press, New York, pp. 375-405, 1982.
17.
Nabeshima, T., Kameyama, T., Sivam, S. P. and Ho, I. K. Mechanism of tolerance development
to pentobarbital in relation to GABAergic neuronal and dispositional functions in mice. J.
Pharmacobio-Dynamics 6, S-61, 1983.
18.
Nabeshima, T., Hiramatsu, M., Amano, M., Furukawa, H., Ho, I. K. and Kameyama, T. Effects of
acute and chronic administration of phencyclidine on methionine-enkephalin content in mouse
brain. In: Phencyclidine and Related Arylcyclohexylamines: Present and Future Applications,
eds. J. M. Kamenka, E. F. Domino and P. Genest. NPP Books, Ann Arbor, MI, pp. 617-625,
1983.
19.
Baggett, J., Hoskins, B., Ho, I. K. and Berndt, W. O. Effect of diisopropylphosphofluoridate (DFP)
on renal/transport. In: Development in the Science and Practice of Toxicology, eds., A. W.
Hayes, R. C. Schnell and T. S. Miya, Elsivier, pp. 447-450, 1983.
20.
Norris, J. C., Nabeshima, T., Fontenot, H. J., Wilson, R. D. and Ho, I. K. Phencyclidine and
GABA system. In: Cellular and Molecular Neurotoxicity of Environmental Agents, ed. T.
Narahashi, Raven Press, New York, pp. 191-205, 1984.
21.
Lim, D. K., Hoskins, B. and Ho, I. K. Environmental toxicology: Aspects of tolerance development
to organophosphorus cholinesterase inhibitor. In: Seminar on Environmental Toxicology,
sponsored by Coordination Council for North American Affairs and American Institute in Taiwan,
pp. 272-293, 1985.
22.
Ho, I. K., Sivam, S. P., Fernando, J. C. R., Lim, D. K. and Hoskins, B. Striatal dopamine-aminobutyric acid-acetylcholine interaction in organophosphate-induced neurotoxicity. In:
Advances in Behavioral Biology, Vol. 30. Dynamics of Cholinergic Function. Ed. I. Hanin,
Plenum Press, N. Y., pp. 719-746, 1986.
23.
Ho, I. K. and Hoskins, B. Barbiturates. In: Mechanisms of Drug Action, ed. G. N. Woodruff. The
Macmillan Press Ltd., London, pp. 177-201, 1986.
24.
Ho, I. K. and Hoskins, B. Biochemical and pharmacological aspects of neurotoxicology from and
tolerance to organophosphorus cholinesterase inhibitors. In: Handbook of Toxicology, eds. T. J.
Haley and W. O. Berndt. Hemisphere Publishing Corporation. Washington, D.C., pp. 44-73,
1987.
25.
Ho, I. K. Barbiturate Sedative-Hypnotics. In: Toxicity of Central Nervous System Depressants,
ed. I. K. Ho, CRC Press, Inc. Boca Raton, FL., pp. 33-55, 1987.
35
26.
Ho, I. K. and Hoskins, B. Pharmacologic and toxicologic approach to the detection of toxic
substances in foods and drugs. Proceedings of Workshop on the Science and Technology of
Food and Drug Safety. Bureau of Food and Drug Safety, Department of Health, Republic of
China pp. 27-49, 1987.
27.
Ho, I. K. Interactions in neurotoxicology. Neurotoxicology 9: 151-152, 1988.
28.
Ho, I. K. and Hoskins, B. Biochemical methods for neurotoxicological analyses of neuroregulators
and cyclic nucleotides. In: Principles and Methods of Toxicology, ed. A. W. Hayes, Raven Press,
New York, pp. 573-598, 1989.
29.
Fujimori, K., Miyaoka, T., Mizokami, K., Sunouchi, M., Inoue, K., Takanaka, A., Omori, Y. and Ho,
I. K. A new method for the assay of acetylcholine and the effects of neurotoxic insecticides on
CNS acetylcholine, catecholamine and GABA systems in the mouse. In: Microwave Irradiation
for Histological and Neurochemical Investigations, eds. C.L. Blank, S. Howard and Y.
Maruyama, Soft Science Publications. Tokyo, pp. 83-97, 1989.
30.
Saunders, P.A. and Ho, I. Barbiturates and the GABAA receptor complex. Progress in Drug
Research, 34: 261-286, 1990.
31.
Yamamoto, I., Kimura, T., Watanabe, K., Tateoka, Y. and Ho, I. K. Action mechanism for
hypnotic activity of N3-benzyluridine and related compounds. In: Endogenous sleep factors, ed.
S Inoue` and J. M. Krueger, SPB Academic Publishing, The Hague, The Netherlands, 1990.
32.
Ho, I. K. and Hoskins, B. Neurotoxicants and gamma-aminobutyric acid receptors. J. Toxicol.
Sci. 15 (Supplement IV): 3-13, 1990.
33.
Ho, I. K. and Hoskins, B. Dopamine in organophosphate-induced neurotoxicity. J. Toxicol. Sci.
15 (Supplement IV): 159-161, 1990.
34.
Ho, I. K. Gamma-aminobutyric acid and neurotoxicity. Proceedings of the Sino-US Bi-National
Conference on Toxicology. pp. 19-32, 1990.
35.
Ho, I. K., Kimura, T., Saunders, P. A., Kim, H. S. and Rheu, H. M. Effects of ginsenosides on
GABAA and GABAB receptors. Proceedings of the International Symposium on Korean Ginseng,
pp. 48-53, 1990.
36.
Ho, I. K. and Yu, S. Effects of barbiturates on GABA system: Comparisons to alcohol and
benzodiazepines. Keio J. Med. 40: 183-186, 1991.
37.
Hoskins, B. and Ho, I. K. Tolerance to organophosphorus cholinesterase inhibitors. In:
Organophosphates: Chemistry, Fate, and Affects, eds. J. E. Chambers and P. E. Levi.
Academic Press, San Diego, p.p. 285-297, 1992.
38.
Hume, A. S. and Ho, I. K. Toxicity of solvents. In: Basic Environmental Toxicology, eds., L. G.
Cockerham and B. S. Shane, CRC Press, Boca Raton, FL, pp. 157-184, 1993.
39.
Tseng, Y. T., Wellman, S. E. and Ho, I. K. Sedative-hypnotics: Addiction and current research
status. J. Food and Drug Analysis 1: 311-325, 1993.
40.
Farley, J. M. and Ho, I. K. Receptors and neurotransmitters in neurotoxicology. In: Handbook of
Neurotoxicology. ed. L. W. Chang, Marcel Dekker, New York, pp. 69-92, 1994.
41.
McCaslin, P. P. and Ho, I. K. Cell Culture in Neurotoxicology. In: Principles and Methods of
Toxicology, ed. A. W. Hayes, Raven Press, New York, pp. 1315-1334, 1994.
36
42.
Ho, I. K. and Fan, A. M. General Toxicology. In: Toxicology and Risk Assessment . ed. Anna M.
Fan and Louis W. Chang, Marcel Dekker, Inc. New York. pp. 1-2, 1996.
43.
Ho, I. K. and Fan, A. M. Principles of Neurotoxicology. In: Toxicology and Risk Assessment . ed.
Anna M. Fan and Louis W. Chang, Marcel Dekker, Inc. New York. pp. 57-70, 1996.
44.
Ho, I. K. and Fan, A. M. Neurotoxicity Testing. In: Toxicology and Risk Assessment. ed. Anna M.
Fan and Louis W. Chang, Marcel Dekker, Inc. New York. pp. 187-202, 1996.
45.
Kimura, T., Chun, Y. S., Ikeda, M., Kobana, K., Watanabe, K., Kondo, S., Ho, I. K. and
Yamamoto, I. Hypnotic activities of N3-benzyl and xylyl substituted arabinofuranosyluracil.
Nucleic Acids Symp. Series No. 37: 229-230, 1997.
46.
Kimura, T., Ohno, M., Ikeda, M., Watanabe, K., Kondo, S., Ho, I. K. and Yamamoto, I. Antianxiety
effects of phenacyluridine in mice. Nucleic Acid Sympo. Series 39: 195-196, 1998.
47.
Wongchanapai, W., Tsang, B. K. and Ho, I. K. The -opioid receptor in opioid dependence. J.
Food Drug Anal. 7: 1-12, 1999.
48.
Rockhold, R.W., Zhu, H., Liu, N. and Ho, I.K. N-methyl-D-aspartate receptors in opioid
dependence and withdrawal. In: Catecholamine Research, ed. Nagatsu et al. Kluwer
Academic/Plenum Publishers, pp. 389-392, 2002.
BOOK EDITED:
Ho, I. K. Toxicology of CNS Depressants. CRC Press, Boca Raton, FL, 267 pages, 1987.
37
ABSTRACTS
1.
Ho, I. K. and Ellman, G. L. Preparation of soluble acetylcholinesterase from rat brain. Pacific
Slope Biochemical Conference, p. 26, 1967.
2.
Ungar, G., Ho, I. K. and Galvan, L. Isolation of a dark avoidance inducing brain peptide. Fed.
Proc. 29: 658, 1970.
3.
Ho, I. K. Studies of solubilized rat brain acetylcholinesterase. Dissertation Abst. (B)32 (2): 508,
1970.
4.
Ungar, G., Ho, I. K. and Galvan, L. Isolation of a behavior-inducing peptide from brain.
Transactions of the Amer. Soc. of Neurochem. 1: 73, 1970.
5.
Ho, I.K. and Keats, A. S. Effect of anesthetics on sulfhydryl content of rat brain. Yearbook of
Anesthesia, p. 23, 1970.
6.
Loh, H. H., Ho, I.K., Lu, S. E. and Way, E. L. Effect of c-AMP on morphine analgesia.
Pharmacologist 13: 313, 1971.
7.
Ho, I K., Lu, S. E., Loh, H. H. and Way, E. L. Effects of c-AMP on morphine tolerant and physically
dependent mice. Pharmacologist 13: 314, 1971.
8.
Ho, I. K., Loh, H. H. and Way, E. L. Influence of cyclic AMP on morphine tolerance and physical
dependence. 5th Int. Cong. Pharmacol. p. 103, 1972.
9.
Ho, I. K., Loh, H. H. and Way, E. L. Effect of c-AMP on morphine analgesia, tolerance and
physical dependence. Presented at 5th Annual Winter Conference on Brain Research, Vail,
Colorado, Jan 15-21, 1972.
10.
Iwamoto, E. T. and Ho, I. K. The effects of MAO inhibition on morphine analgesia in mice. Fed.
Proc. 31: 504, 1972.
11.
Bhargava, H. N., Ho, I. K. and Way, E. L. Effect of dopamine B-hydroxylase (DBH) inhibitor on
morphine analgesia, tolerance and physical dependence in mice. 5th Int. Cong. Pharmacol. p.
21, 1972.
12.
Iwamoto, E. T., Ho, I. K., Way, E. L. and Leake, C. D. Brain dopamine elevation after naloxone
precipitated withdrawal in morphine dependent mice and rats. Fed. Proc. 32: 758, 1973.
13.
Ho, I. K., Loh, H. H. and Way, E. L. Effect of gamma-aminobutyric acid (GABA) on morphine
analgesia, tolerance and physical dependence. Fed. Proc. 32: 758, 1973.
14.
Ho, I. K., Brase, D. A., Loh, H. H. and Way, E. Leong. Serotonergic destruction and blockage on
morphine tolerance and physical dependence. 4th Int. Soc. Neurochem., Aug. 26-31, Tokyo,
1973.
15.
Ho, I. K., Sutherland, V. C. and Loh, H. H. The rapid development of tolerance to barbiturates by
pellet implantation. Soc. Neurochem., Nov. 7-10, San Diego, Calif., 1973.
16.
Ho, I. K. and Loh, H. H. Effect of L-2,4-diaminobutyric acid and B-alanine on tolerance and
physical dependence. Fed. Proc. 33: 501, 1974.
17.
Ho, I. K., Yamamoto, I., Loh, H. H. and Way, E. L. Enhancement of pentobarbital responses after
morphine addiction. Pharmacologist 16: 193, 1974.
38
18.
Yamamoto, I., Ho, I. K. and Loh, H. H. Acceleration of pentobarbital metabolism in tolerant mice
induced by pentobarbital pellet implantation. Pharmacologist 16: 217, 1974.
19.
Ho, I. K., Loh, H. H. and Way, E. L. Potentiation of narcotic lethality by choline. Fed. Proc. 34:
714, 1975.
20.
Sampath-Khanna, S., Iwamoto, E. T., Ho, I. K. and Ellman, G. L. Possible modes of pargyline
action in morphine abstinence. Fed. Proc. 34: 736, 1975.
21.
Hu, J. and Ho, I. K. Susceptibility to electro-shock convulsion after barbiturate pellet implantation
in the mouse. Pharmacologist 17: 190, 1975.
22.
Tzeng, S. F. and Ho, I. K. Effect of acute and chronic morphine administration on brain glutamate
(GLU) and q-aminobutyrate (GABA) levels in the mouse. Pharmacologist 17: 238, 1975.
23.
Ho, I.K. and Tzeng, S. F. Acute and chronic morphine administration on brain -aminobutyric acid
(GABA) levels in the mouse. Neuroscience 5th Annual Meeting, 290 abs., 1975.
24.
Tzeng, S. F. and Ho, I. K. Effects of acute and chronic pentobarbital administration on brain qaminobutyric (GABA) and glutamate (GLU) levels in the mouse. Fed. Proc. 35: 564, 1976.
25.
Tzeng, S. F. and Ho, I. K. Acute and chronic effect of pentobarbital on glutamic acid
decarboxylase (GAD) activity in discrete areas of mouse brain. Pharmacologist 18: 235, 1976.
26.
Yang, J. R., Thureson-Klein, A. and Ho, I. K. Effect of morphine and pentobarbital on mouse
cerebellum: an ultrastructural and biochemical study. Pharmacologist 18: 235, 1976.
27.
Takanaka, A. and Ho, I. K. Effects of SKF-525A on pentobarbital tolerant and non-tolerant mice.
Pharmacologist 18: 235, 1976.
28.
Branning, P. K., Takanaka, A., Tzeng, S. F. and Ho, I. K. Continuous administration of barbital by
pellet implantation procedure. Pharmacologist 18: 235, 1976.
29.
Desaiah, D. and Ho, I. K. Effects of acute and chronic morphine administration on mouse brain
adenosine triphosphatase activities. Pharmacologist 18: 212, 1976.
30.
Hayes, A. W., Desaiah, D. and Ho, I. K. Effects of rubratoxin B and aflatoxin B1 on ATPase
activities in the mouse. Pharmacologist 18: 170, 1976.
31.
Takanaka, A., Tzeng, S. F. and Ho, I. K. Effect of acute and chronic morphine administration on
glutamic acid decarboxylase (GAD) activity in discrete areas of mouse brain. Neuroscience 6th
Annual Meeting, Toronto, Canada, Nov. 7-11, 1976.
32.
Becker, K. E., Jr. and Ho, I. K. Pentobarbital distribution in discrete brain areas of tolerant and
non-tolerant mice. American Society of Anesthesiologists, San Francisco, Calif., Sept. 8-14,
1976.
33.
Yang, J. R., Thureson-Klein, A. and Ho, I. K. Acute and chronic effects of pentobarbital on mouse
hepatocytes, Fall Meeting, Louisiana Society for Electron Microscopy, Biloxi, Mississippi, Oct.
22, 1976.
34.
Desaiah, D., Hume, A. S. and Ho, I. K. Activation of ATPase activities in mouse brain
synaptosomes by catecholamines. Fed. Proc. 36: 989, 1977.
35.
Desaiah, D., Ho, I. K. and Mehendale, H. M. Effect of kepone and mirex on hepatic mitochondrial
Mg++ ATPase activity. 173rd ACS National Meetings, New Orleans, LA, March 20-25, 1977.
39
36.
Mehendale, H. M. and Ho, I. K. Morphine and pentobarbital-induced modification of hepatobiliary
disposition of methadone. Fed. Proc. 36: 1000, 1977.
37.
Thureson-Klein, A., Wang-Yang, J. R., Ho, I. K. and Martenssen, E. Implantation. Newsletter,
Texas Society for Electron Microscopy 8: 23, 1977.
38.
Desaiah, D. and Ho, I. K. Activation of ATPase activities in mouse brain synaptosomes by
catecholamines. J. Miss. Acad. Sci. 22: 43, 1977.
39.
Wang-Yang, J. R., Thureson-Klein, A. and Ho, I. K. Effects of continuous administration of
morphine (M) on mouse hepatocyte ultrastructure. Fed. Proc. 36: 1001, 1977.
40.
Hayes, A. W., Ho, I. K., Takanaka, A. and Watson, S. A. Acute toxicity of rubratoxin B in mice.
First International Congress on Toxicology. Toronto, Canada. March 29 - April 2, 1977.
41.
Ho, I. K. and Takanaka, A. Effects of morphine pellet (MP) implantation on liver in the mouse.
Pharmacologist 19: 157, 1977.
42.
Berndt, W. O. and Ho, I. K. Effects of morphine sulfate on renal transport processes.
Pharmacologist 19: 156, 1977.
43.
Desaiah, D. and Ho, I. K. Catecholamine-sensitive ATPase activities in brain synaptosomes of
morphinized mice. Pharmacologist 19: 144, 1977.
44.
Desaiah, D., Mehendale, H. M. and Ho, I. K. Kepone inhibition of mouse brain synaptosomal
ATPase activities. Society of Toxicology Meeting, San Francisco, CA. March 12-16, 1978.
45.
Phillips, T. D., Hayes, A. W., Ho, I.K. and Desaiah, D. Effects of rubratoxin B on the kinetics of
cationic and substrate activation of Na+-K+ ATPase and para-nitrophenyl phosphatase. Fed.
Proc. 37: 501, 1978.
46.
Mehendale, H. M., Ho, I. K. and Desaiah, D. Mirex-induced interference of energy metabolism
and hepatobiliary dysfunction. Fed. Proc. 37: 299, 1978.
47.
Desaiah, D., Philliips, T. D., Hayes, A. W. and Ho, I. K. Effects of aflatoxins on ATPase activities
in rat and mouse. Fed. Proc. 37: 502, 1978.
48.
Ho, I. K. and Gilliland, T. Acute and chronic morphine administration on pyridoxal phosphate (PP)
dependent glutamic acid decarboxylase (GAD) activities. Fed. Proc. 37: 770, 1978.
49.
Flint, B. A., Jr., Ho, I. K. and Berndt, W. O. A method for producting tolerance to and physical
dependence on barbital in male ICR mice. J. Miss. Acad. Sci. 23: 46, 1978.
50.
Gilliland, T., Chang, H. Y-Y. and Ho, I. K. The effect of morphine administration on the affinity of
glutamic acid decarboxylase (GAD) for pyridoxal phosphate. J. Miss. Acad. Sci. 23: 47, 1978.
51.
Ho, I. K. and Flint, B. A. A rodent model for inducing barbiturate tolerance and dependence. 7th
International Congress of Pharmacology, Paris, France. July 16-21, 1978.
52.
Desaiah, D., Ho, I. K. and Chang, Y-Y. H. Effects of acute and chronic morphine administration
on hepatic function. 7th International Congress of Pharmacology, Paris, France, July 16-21,
1978,
53.
Sun, G. Y., Hallett, D. and Ho, I. K. Effect of morphine on oleoyl CoA: 1-Acyl-phosphoglyceride
acyltransferase and hepatic triacylglycerol (TG) accumulation. Pharmacologist, 20: 242, 1978.
40
54.
Flint, B. A., Onoda, K. and Ho, I. K. Pentobarbital tolerance-dependence induced by long term
pellet implant. Pharmacologist 20: 165, 1978.
55.
Fontenot, J., Chang, Y. H., Mehendale, H. M. and Ho, I. K. Potentiation of mortality by carbon
tetrachloride (CCl4) during morphine pellet (MP) implantation in the mouse. Pharmacologist 20:
270, 1978.
56.
Chang, Y. H. and Ho, I. K. Effect of morphine on mouse serum glutamic oxalacetate
transaminase (SGOT) and serum glutamic pyruvate transaminase (SGPT) activity.
Pharmacologist 20: 242, 1978.
57.
Ho, I. K., Flint, B. A. Onoda, K. and Berndt, W. O. Development of cross tolerance to barbiturate
by phencyclidine chronic administration. Pharmacologist 20: 165, 1978.
58.
Desaiah, D., Gilliland, T., Mehendale, H. M. and Ho, I. K. Inhibition of 3H-ouabain binding to
mouse brain synaptosomes by Kepone. Pharmacologist 20: 195, 1978.
59.
Trottman, C. H., Desaiah, D. and Ho, I. K. Effect of preexposure to toxaphene on rat hepatic drug
metabolizing enzymes. Pharmacologist 20: 199, 1978.
60.
Mo, B. P. N., Flint, B. A., Rigor, B. M. and Ho, I. K. Enhancement of pharmacologic responses of
pentobarbital by Dopram®. 1978 Annual Meeting of American Society of Anesthesiology,
Baltimore, MD, Oct. 1978.
61.
Ho, I. K., Flint, B. A. and Onoda, K. Potentiation of pharmacologic responses to barbiturates by
Dopram® and its preservative. 18th Annual Meeting of Society of Toxicology, New Orleans, LA,
March 11-15, 1979.
62.
Chang, Y.-Y. H. and Ho, I. K. Effect of Kepone on GABA uptake in mouse brain synaptosomes.
J. Miss. Acad. Sci. 24 (suppl.): 69, 1979.
63.
Flint, B. A., Ho, I. K. and Onoda, K. The enhancement of pharmacologic responses of
barbiturates by Dopram®. J. Miss. Acad. Sci. 24 (suppl.): 65, 1979.
64.
Ho, I. K., Flint, B. A. and Gilliland, T. Comparative effects of diazepam and valproate on
pentytenetetrazol (PTZ) induced convulsions in pentobarbital dependent mice. Fed. Proc. 38:
438, 1979.
65.
Huang, D. T.-P., Ho, I. K., Mehendale, H. M. and Hume, A. S. Neurotoxicity induced by oral
administration of Kepone® (chlordecone) in the mouse. Fed. Proc. 38: 845, 1979.
66.
Sun, G. Y. and Ho, I. K. Morphine induced changes in acyl groups of glycerolipids in mouse liver.
XIth International Congress of Biochemistry, Toronto, Canada, March, 1979.
67.
Curtis, L. R., Onoda, K., Ho, I. K. and Mehendale, H. M. Induction of hepatic mixed function
oxidases in the male rat by photomirex. J. Miss. Acad. Sci. 24 (suppl.): 67, 1979.
68.
Trottman, C. H., Desaiah, D. and Ho, I. K. Induction of rat hepatic microsomal enzymes by
toxaphene pretreatment. J. Miss. Acad. Sci. 24 (suppl.): 73, 1979.
69.
Onoda, K., Flint, B. A., Nabeshima, T. and Ho, I. K. Effect of chronic pencyclidine (PCP)
administration on hepatic microsomal drug metabolizing enzyme (DME) activity.
Pharmacologist 21: 152, 1979.
41
70.
Flint, B. A. and Ho, I. K Effect of procarbazine on pentylenetetrazol (PTZ) induced convulsions in
pentobarbital dependent mice. Pharmacologist 21: 153, 1979.
71.
Flint, B. A. and Ho, I. K. Assessment of anticonvulsive effect of diazepam in pentobarbital
dependent mice. Society of Neuroscience 9th Annual Meeting, 5: 556, 1979.
72.
Ho, I. K., Fujimori, K., Chang-Tsui, Y.-Y. H., Nabeshima, T. and Mehendale, H. M. Effects of
Kepone and mirex on biogenic amine in the mouse. 18th Annual Meeting of Society of
Toxicology, 1980.
73.
Fujmori, K., Haung, T. P., Ho, I. K. and Mehendale, H. M. Comparison of toxicity induced by oral
administration of mirex and Kepone in the male mouse. 18th Annual Meeting of Society of
Toxicology, 1980.
74.
Ho, I. K. Effects of acute and chronic administration of pentobarbital on GABA system.
International Symposium on GABA and other Inhibitory Neurotransmitters. Nov. 6-10, Myrtle
Beach, SC, 1980.
75.
Fontenot, J., Nabeshima, T., Ho, I. K. and Hume, A. S. Pentobarbital (P) administration on DNA
and RNA synthesis. Fed. Proc. 39: 598, 1980.
76.
Nabeshima, T., Smith, J. and Ho, I. K. Pentobarbital (P) tolerance and dependence in different
strains of mice. Fed. Proc. 39: 518, 1980.
77.
Angevine, L. S., Nabeshima, T., Ho, I. K. and Mehendale, H. M. Effects of xenobiotics on 5-HT
and NE uptake and metabolism in the isolated perfused rabbit lung. 18th Annual Meeting of
Society of Toxicology, 1980.
78.
Nabeshima, T. and Ho, I. K. Effects of acute and chronic morphine (M) administration on GABA
binding of synaptic membrane in mice. Pharmacologist 22: 234, 1980.
79.
Fontenot, J. and Ho, I. K. Effect of pentobarbital administration on protein synthesis in the brain.
Pharmacologist 22: 170, 1980.
80.
Nabeshima, T., Fujmori, K. and Ho, I. K. Effects of acute and continuous administration of
pentobarbital (P) on biogenic amines in the mouse. Pharmacologist 22: 170, 1980.
81.
Fujimori, K. and Ho, I. K. Effects of chlordecone and mirex on dopaminergic system. 19th Annual
Meeting of Society of Toxicology, San Diego, CA, March 1-6, 1981.
82.
Fujimori, K., Ho, I. K. and Mehendale, H. M. Comparative toxicity of mirix, photomirex and
chlordecone after oral administration to the mouse. 19th Annual Meeting of Society of
Toxicology, San Diego, CA, March 1-6, 1981.
83.
Ho, I. K., Fujimori, K., Huang, T. P. and Mehendale, H.M. Brain and plasma distribution of
chlordecone and mirex in the mouse. 19th Annual Meeting of Society of Toxicology, San Diego,
CA, March 1-6, 1981.
84.
Nabeshima, T., Reese, C. and Ho, I. K. Enhancement of phencyclidine (PCP) effects by acute
and chronic morphine administration in mice. Fed. Proc. 40: 319, 1981.
85.
Norris, J. C., Nabeshima, T., Hume, A. S. and Ho, I. K. Effect of phencyclidine (PCP)
administration on GABA system. Fed. Proc. 40: 298, 1981.
86.
Sivam, S. P., Nabeshima, T. and Ho, I. K. Effects of morphine administration on opiate receptor
binding in mice. Fed. Proc. 40: 289, 1981.
42
87.
Hoskins, B. and Ho, I. K. Effects of chlordecone administration on brain calcium contents in the
mouse. Fed. Proc. 40: 629, 1981.
88.
Ho, I. K., Nabeshima, T., Sivam, S. P. and Tai, C. Y. Biochemical studies on cross-tolerance
development to phencyclidine (PCP) in pentobarbital or morphine tolerant mice. Eighth
International Congress of Pharmacology. Tokyo, Japan, July 19-24, 1981.
89.
Nabeshima, T., Kameyama, T. and Ho, I. K. Development of cross-tolerance between
phencyclidine (PCP) and morphine in mice. Eighth International Congress of Pharmacology.
Tokyo, Japan, July 19-24, 1981.
90.
Sivam, S. P., Nabeshima, T., Kameyama, T. and Ho, I. K. Involvement of GABA in morphine
tolerance and withdrawal: nociceptive, GABA release and receptor-binding studies.
International Narcotic Research Conference. Kyoto, Japan, July 26-30, 1981.
91.
Nabeshima, T., Sivam, S. P., Kameyama, T. and Ho, I. K. Interaction between morphine and
phencyclidine: Intoxication and cross-tolerance. International Narcotic Research Conference.
Kyoto, Japan, July 26-30, 1981.
92.
Fujimori, K. and Ho, I. K. Dopaminergic activity in chlordecone (Kepone\) induced neurotoxicity.
Eighth International Congress on Pharmacology. Tokyo, Japan, July 19-24, 1981.
93.
Berndt, W. O., Hoskins, B., Lim, D. K. and Ho, I. K. The effects of diisopropylfluorophosphate
(DFP) in renal function in the rat. Fed. Proc. 41 (5): 1546, 1982.
94.
Ho, I. K., Sivam, S. P., Hoskins, B. and Norris, J. C. Effect of acute and chronic administration of
diisopropylfluorophosphate on cholinesterase activity, muscarinic, dopamine and GABA
receptors of the rat striatum. Pharmacologist 24 (3): 103, 1982.
95.
Benet, H., Ho, I. K. and Hoskins, B. Effect of chlordecone on discrete brain area calcium
distribution in mice. Pharmacologist 24 (3): 110, 1982.
96.
Hoskins, B., Lim, D. K. and Ho, I. K. Toxicity studies of single and continuous exposure to
diisopropylfluorophosphate (DFP) in rats. Pharmacologist 24 (3): 150, 1982.
97.
Norris, J. C., Nabeshima, T., Sivam, S. P. and Ho, I. K. Alteration of calcium-dependent GABA
release and the enzyme activities of glutamic acid decarboxylase (GAD) and GABA-ketoglutarate transaminase (GABA-T) in response to the acute and chronic administration of
phencyclidine. Toxicologist 2: 1, 1982.
98.
Nabeshima, T., Kameyama, T. and Ho, I. K. Effect of acute and chronic administration of
pentobarbital on calcium-dependent GABA release from mouse brain slices. Fed. Proc. 41:
1640, 1982.
99.
Sivam, S. P. and Ho, I. K. Tolerance development to the antinociceptive and gastrointestinal
effects of morphine: involvement of multiple opiate receptors. Fed. Proc. 41: 1045, 1982.
100.
Sivam, S. P. and Ho, I. K. Influence of GABAeric drugs on morphine response. Pharmacologist
24: 229, 1982.
101.
Nabeshima, T., Sivam, S. P. and Ho, I. K. Influence of morphine tolerance on 3Hdihydromorphine binding in the medulla, diencephalon and cortex of mouse. Pharmacologist
24: 229, 1982.
43
102.
Dulaney, M. D., Jr., Lim, D. K., Hoskins, B. and Ho, I. K. Tolerance to subacute administration of
organophosphate acetylcholinesterase (AChE) inhibitors, Soman, Sarin and Tabun. Fed. Proc.
42: 656, 1983.
103.
Fernando, J. C. R., Hoskins, B. and Ho, I. K. Dopamine and 5-hydroxytryptamine metabolism and
behavioral changes following organophosphate treatment. Fed. Proc. 42: 655, 1983.
104.
Ho, I. K., Sivam, S. P. and Hoskins, B. Acute toxicity of diisopropylfluorophosphate, Tabun, Sarin
and Soman in rats: lethality in relation to cholinergic and GABAergic enzyme activities. Fed.
Proc. 42: 656, 1983.
105.
Hoskins, B., Robertson, M. and Ho, I. K. Effects of acute exposure to sublethal threshold doses
of organophosphates. Fed. Proc. 42: 656, 1983.
106.
Lieu, D. D., Ho, I. K. and Hoskins, B. Striatal cyclic nucleotide levels after single organophosphate
injections to rats. Fed. Proc. 42: 656, 1983.
107.
Sivam, S. P., Nabeshima, T., Lim, D. K., Hoskins, B. and Ho, I. K. Diisopropylfluorophosphate
and GABA synaptic function: effect on levels, enzymes, release and uptake in the rat striatum.
Fed. Proc. 42: 656, 1983.
108.
Ho, I. K., Sivam, S. P., Nabeshima, T., Lim, D. K. and Hoskins, B. Effects of
diisopropylfluorophosphate (DFP) on GABAergic function. Toxicology Letters 18: 130, 1983.
109.
Baggett, J., Hoskins, B., Ho, I. K. and Berndt, W. O. Effect of diisopropylphosphorofluoridate
(DFP) on renal slice transport. Toxicology Letters 18: 124, 1983.
110.
Norris, J. C., Fontenot, H. J., Hume, A. S., Ho, I. K. and Wilson, R. D. Interaction of GABAergic
system and phencyclidine (PCP). Fed. Proc. 42: 1166, 1983.
111.
Lim, D. K., Sivam, S.P., Hoskins, B. and Ho, I. K. Inhibition and recovery of acetylcholinesterase
(AChe) activity in the discrete regions of rat brain following single-dose administration of Soman,
Sarin and Tabun. Pharmacologist 25: 222, 1983.
112.
Yamamoto, I., Tateoka, Y., Watanabe, K., Fontenot, J. and Ho, I. K. Different effects of N-allyl(NAl)- and N,N'-diallyl (N,N'-DAL)-barbiturate on various barbiturate-induced narcosis in the
mouse. Pharmacologist 25: 271, 1983.
113.
Benet, H. C., Norris, J. C., Fontenot, J., Wilson, R. D., Ho, I. K. and Hume, A. S. Effect of
ascorbic acid, fructose-1,6-diphosphate, and L-cystine on cyanide toxicity in rodents.
Pharmacologist 25: 274, 1983.
114.
Norris, J. C., Benet, H. C., Fontenot, H. J., Wilson, R. D., Ho, I. K. and Hume, A. S. Relationship
of toxicities of cyanide (KCN) and carbon monoxide (CO) in mice. Pharmacologist, 25: 273,
1983.
115.
Nabeshima, T., Kameyama, T., Sivam, S. P. and Ho, I. K. GABA receptor changes in the discrete
regions of mouse brain after acute and chronic treatments with morphine. Symposium on
"Neurotransmitter Receptor Regulation, Interactions and Coupling to the Effectors". Hiroshima,
Japan, Oct. 6-8, 1983.
116.
Ho, I. K., Fernando, J. C. R., Lim, D. K. and Hoskins, B. Behavioral tolerance to the toxicity of
Soman and Sarin. Fed. Proc. 43: 565, 1984.
117.
Fernando, J. C. R., Hoskins, B. and Ho, I. K. Behavioral super-sensitivity to atropine following
treatment with organophosphate cholinesterase inhibitors. Fed. Proc. 43: 565, 1984.
44
118.
Sivam, S. P., Lim, D. K., Hoskins, B. and Ho, I. K. Acute toxicity of Soman, Sarin and Tabun:
Neurochemical evaluations related to cholinergic, GABAergic and dopamine systems. Fed.
Proc. 43: 565, 1984.
119.
Lieu, D. D., Hoskins, B. and Ho, I. K. Early biochemical effects of Soman, Sarin and Tabun on
cyclic nucleotides, calmodulin and calmodulin-regulated enzymes in rat brain striata. Fed. Proc.
43: 565, 1984.
120.
Hoskins, B., Ho, I. K. and Meydrech, E. F. Acute and tolerant responses of the striatal calmodulin
system to morphine in mice of different ages. Fed. Proc. 43: 936, 1984.
121.
Yamamoto, I., Nabeshima, T., Tateoka, Y., Watanabe, K., Fontenot, H. J. and Ho, I. K. Effects of
N,N'-diallyl pentobarbital and N,N'-diallyl uracil on pentobarbital metabolism. Fed. Proc. 43:
939, 1984.
122.
Ho, I. K. and Hoskins, B. Effect of acute administration of and tolerance development to
morphine on the striatal calmodulin systems in mice of different ages. Internat. Narcotics
Research Conf., Cambridge, England, July 23-26, 1984.
123.
Yamamoto, I., Tateoka, Y. Watanabe, K., Nebeshima, T. Fontenot, H. J. and Ho, I. K. Effects of
N,N'-diallyl uracil and N.N'-diallyl thymine on mouse hepatic drug metabolizing enzymes. Ninth
International Congress of Pharmacology. London, England, July 29-Aug. 3, 1984.
124.
Ho, I. K., Fernando, J. C. R., Sivam, S. P. and Hoskins, B. Dopaminergic system in
organophosphate-induced side effects. Ninth International Congress of Pharmacology. London,
England. July 29-Aug. 3, 1984.
125.
Dulaney, M., Rockhold, R., Hoskins, B. and Ho, I. K. Effects of DFP on drinking behavior and
urinary excretions. Pharmacologist 26: 227, 1984.
126.
Aldous, C., Norris, J., Balter, A., Fontenot, J., Wilson, R., Ho, I. K. and Hume, A. Formation of
cyanohydrins and antagonism of cyanide toxicity by some carbonyl compounds.
Pharmacologist 26: 230, 1984.
127.
Lieu, D. D., I. K. Ho and B. Hoskins. Acute effects of Soman, Sarin and Tabun on cyclic
nucleotide metabolism in rat striatum. Toxicologist 5: 144, 1985.
128.
Stokes, K. B., Ho I. K. and Lee N. M. Organophosphate treatment alters brain opioid peptide
levels. Fed. Proc. 44: 425, 1985.
129.
Burton, C. K., Ho I. K. and Hoskins B. Effects of naloxone, acute and chronic morphine
administration on striatal cyclic nucleotide metabolism. Fed. Proc. 44: 610, 1985.
130.
Moore, S. J., Norris J. C., Wilson R. D., Ho I. K. and Hume A. S. The efficacy of a-ketogulutaric
acid in the antagonism of cyanide intoxiciation. Fed. Proc. 44: 719, 1985.
131.
Watanabe, H. K., Hoskins B. and Ho I. K. Specific inhibitory effect of organophosphorus
cholinesterase inhibitors on UDP-glucuronyltransferase activities in rat liver microsomes. Fed.
Proc. 44: 1629, 1985.
132.
Lim, D. K., Hoskins B. and Ho I. K. Correlation of recoveries of muscarinic receptor density and
acetylcholinesterase activity after repeated diisopropylfluorophosphate (DFP) treatment. Fed.
Proc. 44: 1629, 1985.
45
133.
Fernando, J. C. R., Hoskins B. and Ho I. K.. Influence of acetylcholinesterase inhibition on the
dopaminergic system. Fed. Proc. 44: 1629, 1985.
134.
Hoskins, B., Fernando J. C. R., Dulaney M. D., Lim D. K., Lieu D. D., Watanabe H. K. and Ho I.
K., Relationship between the neurotoxicities of Soman, Sarin and Tabun, and
acetylcholinesterase inhibition. Fed. Proc. 44: 1630, 1985.
135.
Watanabe, H. K., Liu, D. D., Hoskins, B. and Ho, I. K. Acute effects of organophosphates on
Ca++ and Mg++ contents in rat brain. Toxicologist 6: 21, 1986.
136.
Fernando, J. C. R., Hoskins, B. and Ho, I. K. Subacute effects of Soman (SM), Sarin (SR) and
Tabun (TB) on muscarinic receptors of rat brain. Toxicologist 6: 18, 1986.
137.
Lim, D. K., Fernando, J. C., Hoskins, B. and Ho, I. K. Quantitative assessment of tolerance
development to diisopropylfluorophosphate (DFP). Fed. Proc. 45: 791, 1986.
138.
Dulaney, M., Porter, A., Rockhold, R., Hoskins, B. and Ho, I. K. Dipsogenic and diuretic effects
following hypothalamic acetylcholnesterase (AChE) inhibition by diisopropylfluorophosphate
(DFP). Fed. Proc. 45: 192, 1986.
139.
Hoskins, B., Fernando, J. C. and Ho, I. K. Subacute toxicity of Soman, Sarin and Tabun in rats.
Fed. Proc. 45: 791, 1986.
140.
Burton, C. K., Ho, I. K. and Hoskins, B. Behavioral responses to and brain distribution of
morphine in mature adult and aged mice. Fed. Proc. 45: 666, 1986.
141.
Fernando, J. C., Hoskins, B. and Ho, I. K. Effect of paraoxon on muscarinic, dopamine and qaminobutyric acid receptors of brain and sensitivity to muscarinic antagonists. Fed. Proc. 45:
791, 1986.
142.
Prasada Rao, K. S., Fernando, J. C., Ho, I. K. and Mehendale, H. M. Neurotoxicity in rats
following subchronic amiodarone treatment. Fed. Proc. 45: 804, 1986.
143.
Ho, I. K., Lim, D. K. and Hoskins, B. Tolerance development to diisopropylfluorophosphate (DFP)
and its effect on the central cholinergic synapse in rats. IV International Congress of
Toxicology. Tokyo, Japan, July 21-25, 1986.
144.
Watanabe, H. K., Hoskins, B. and Ho, I. K. Effect of diisopropylfluorophosphate on UDPglucuronyl transferase activities in rat liver microsomes. IV International Congress of
Toxicology. Tokyo, Japan, July 21-25, 1986.
145.
Moore, S. J., Ho, I. K. and Hume, A. S. Lethalities produced by concomitant exposure to
sublethal doses of cyanide (CN) and carbon monoxide (CO). Joint meeting of American Society
for Pharmacology and Experimental Therapeutics and Society of Toxicology. Baltimore, MD.
August 17-21, 1986.
146.
Hoskins, B., Fernando, J. C. R., Dulaney, M. D., Lim, D. K., Liu, D. D., Watanabe, H. K. and Ho, I.
K. Tolerance to soman, sarin, and tabun. Fed. Proc. 46: 859, 1987.
147.
Lim, D. K., Porter, A. C., Hoskins, B. and Ho, I. K. Changes in acetylcholine (ACh) levels in the rat
brain during subacute administration of diisopropylfluorophosphate (DFP). Fed. Proc. 46: 860,
1987.
150.
Horan, P. J. and Ho, I. K. Differential interactions between narcotic analgesics and diazepam.
Fed. Proc. 46: 383, 1987.
46
151.
Burton, C. K., Ho, I. K. and Hoskins, B. Evidence that cyclic GMP-phosphodiesterase is involved
in morphine tolerance. Fed. Proc. 46: 383, 1987.
152.
Dulaney, M. D., Porter, A., Rockhold, R. W., Kirby, A. W., Hoskins, B. and Ho, I.K.
Characterization of the dipsogenic, diuretic and urinary electrolyte excretion responses following
hypothalamic acetylcholinesterase inhibition by diisopropylfluorophosphate (DFP). Fed. Proc.
46: 860, 1987.
153.
Rockhold, R. W., Hoskins, B. and Ho, I. K. Spontaneously hypertensive rats are resistant to
convulsive and lethal actions of cocaine. Fed. Proc. 46: 402, 1987.
154.
Liu, D. D., Ueno-Ito, E., Ho, I. K. and Hoskins, B. Effects of soman convulsion on cyclic
nucleotide levels in rat striatum, cerebellum, and spinal cord. Fed. Proc. 46: 859, 1987.
155.
Watanabe, H. K., Hoskins, B. and Ho, I. K. Sensitivity difference to hepatotoxicity of cocaine in
spontaneously hypertensive and Wistar-Kyoto rats. Pharmacologist 29: 160, 1987.
156.
Yamamoto, I., Tateoka, Y., Kimura, T., Watanabe, K., Hume, A. S. and Ho, I. K. (l-1)-HydroxyN,N'-diallylpentobarbital: An active metabolite of N,N'-diallylpentobarbital possessing a potent
prolonging effect on the pentobarbital-induced sleep. Xth International Congress of
Pharmacology, Sydney, Australia, August 23-28, 1987.
157.
Lim, D. K., Ito, Y., Porter, A. B., Hoskins, B., Ho, I. K. and Rockhold, R. W. Comparison of
cholinesterase activities and muscarinic and dopaminergic receptors among three different rat
strains: S. D., WKY and SHR. Abstracts of 17th Annual Meeting of the Society for
Neuroscience, , New Orleans, LA, p. 936, November 16-21, 1987
158.
Ito, Y., Lim, D. K., Hoskins, B. and Ho, I. K. Subacute administration of bicuculline on GABA
receptor characteristics in rat brain. Abstracts of 17th Annual Meeting of the Society for
Neuroscience, New Orleans, LA, p. 963, November 16-21, 1987,
159.
Horan, P. and Ho, I. K. Acute and subacute studies with butorphanol and morphine. FASEB J. 2:
A367, 1988.
160.
Lim, D. K., Ito,Y., Yu, Z. J., Hoskins, B. and Ho, I. K. Protection of soman-induced toxicity by the
continuous administration of physostigmine in guinea pigs. FASEB J. 2: A597, 1988.
161.
Ueno, E., Liu, D., D., Rockhold, R. W., Ho, I. K. and Hoskins, B. The effect of cocaine
administration on calmodulin content and on the activities of cyclic AMP-phosphodiesterase and
cyclic GMP-phosphodiesterase. FASEB J. 2: A1065, 1988.
162.
Ito, Y., Lim, D. K., Hoskins, B. and Ho, I. K. Effects of picrotoxin administration on GABAAreceptor complex in rat brain. FASEB J. 2: A1400, 1988.
163.
Ho, I. K., Ishizuka, Y., Rockhold, R. W. and Hoskins, B. Subacute cocaine treatment differentially
alters regional brain opiate receptor binding in SHR and WKY. FASEB J. 2: A1803, 1988.
164.
Ishizuka, Y., Rockhold, R. W., Hoskins, B. and Ho, I. K. Restrain alters circulatory, convulsant
and body temperature responses to cocaine differentially in SHR and WKY. FASEB J. 2:
A1803, 1988.
165.
Saunders, P.A., Ito, Y. and Ho, I. K. Effects of acute pentobarbital and pentobarbital tolerance on
3H-muscimol binding in the rat frontal cortex. FASEB J. 2: A1807, 1988.
166.
Ishizuka, Y., Rockhold, R. W., Hoskins, B. and Ho, I. K. Stress-induced changes in some
responses to cocaine in SHR. J. Clin. Pharmacol. 28: 957 abs., 1988.
47
167.
Horan, P. J. and Ho, I. K. Comparative pharmacological and biochemical studies with
butorphanol and morphine. J. Clin. Pharmacol. 28: 957 abs., 1988.
168.
Lim, D. K., Ito, Y., Yu, Z. J., Hoskins, B. and Ho, I. K. Protection of soman-induced toxicity by the
continuous administration of physostigmine in guinea pigs. J. Clin. Pharmacol. 28: 957 abs.,
1988.
169.
Saunders, P. A., Ito, Y. and Ho, I. K. Effects of acute pentobarbital administration, tolerance, and
dependence on GABAA receptor binding in discrete areas of the rat brain. J. Clin. Pharmacol.
28: 958 abs., 1988.
170.
Horan, P. J. and Ho, I. K. Butorphanol exhibits multiple actions on the opioid receptor system.
Pharmacologist 30: 154., 1988.
171.
Lim, D. K., Ito, Y., Hoskins, B. and Ho, I. K. Osmotic mini-pump infusion on physostigmine and
muscarinic receptor blockers as protection against soman in guinea pigs. Toxicologist 9: 220.,
1989.
172.
Lim, D. K., Ito, Y., Yu, Z. J., Hoskins, B., Rockhold, R. W. and Ho, I. K. Effects of cocaine on
striatal dopamine receptors in WKY and SHR. FASEB J. 3: A418, 1989.
173.
Carver, S., Rockhold, R. W., Ishizuka, Y., Hoskins, B. and Ho. I. K. Dopaminergic receptor
blockade differentially alters cocaine toxicity in SHR and WKY. FASEB J. 3: A419, 1989.
174.
Ishizuka, Y., Rockhold, R. W., Hoskins, B. and Ho, I. K. Importance of route of administration in
body temperature responses to cocaine in restrained and freely moving SHR and WKY.
FASEB J. 3: A419, 1989.
175.
Horan, P. J. and Ho, I. K. Butorphanol precipitates abstinence in morphine dependent rats.
FASEB J. 3: A422, 1989.
176.
Burton, C. K., Ho, I.K. and Hoskins, B. More evidence for the involvement of cyclic GMPphosphodiesterase in morphine tolerance. FASEB J. 3: A422, 1989.
177.
Saunders, P. A., Ito, Y. and Ho. I. K. Effects of pentobarbital tolerance and withdrawal on the
GABAA receptor. FASEB J. 3: A723, 1989.
178.
Lim, D. K., Yu, Z. J., Hoskins, B., Rockhold, R. W. and Ho, I. K. Effects of cocaine on striatal
dopamine uptake in WKY and SHR. Pharmacologist 31: 159, 1989.
179.
Yu, Z. J., Lim, D. K., Hoskins, B. Rockhold, R. W. and Ho, I. K. Effects of cocaine on striatal
dopamine (DA) and its metabolites in WKY and SHR. Pharmacologist 31: 159, 1989.
180.
Rockhold, R. W. Ishizuka, Y. Carver, S., Hoskins, B. and Ho, I. K. Cocaine-induced toxicity and
body temperature responses to cocaine in spontaneously hypertensive rats. Society for
Neuroscience Abstracts: 15: 801, 1989.
181.
McCaslin, P. P., Huang, M-F., Smith, T. G. and Ho, I. K. Amitriptyline protects against NMDAinduced toxicity in cultures of cerebellar granules cells. FASEB J. 4(3): A618, 1990.
182.
Yu, Z. J., Lim, D. K., Hoskins, B., Rockhold, R. W. and Ho, I. K. Effects of cocaine on dopamine
and its metabolites in nucleus accumbens between WKY and SHR. FASEB J. 4(3): A745,
1990.
48
183.
Hoskins, B., Rockhold, R. W. and Ho, I. K. Differential effects of cocaine administration on
tyrosine hydroxylase activity in brain areas from Wistar Kyoto and spontaneously hypertensive
rats. FASEB J. 4(3): A745, 1990.
184.
Yu, Sue and Ho, I. K. Effects of GABA antagonists, SR 95531 and Bicuculline, on GABA
receptor-regulated 36Cl- flux in rat cortical synaptoneurosomes. FASEB J. 4(4): A1131, 1990.
185.
Kimura, Toshiyuki, Saunders, Paul A., Yamamoto, Ikuo and Ho, I. K. Studies on the effects of
pentobarbital tolerance and withdrawal on GABAB receptor. FASEB J. 4(4): A1131, 1990.
186.
Saunders, Paul A., Kimura, Toshiyuki and Ho, I. K. Effects of pentobarbital tolerance and
withdrawal on GABAA receptor antagonist binding. FASEB J. 4(4): A1131, 1990.
187.
Ho, I. K., Ito, Y. and Lim, D. K. Effects of picrotoxin and pentobarbital on GABAa receptor
complex. IUPHAR abstracts, 1990.
188.
Kimura, Toshiyuki, Saunders, Paul A., Yamamoto, Ikuo and Ho, I. K. Effects of pentobarbital
tolerance and withdrawal on GABAB receptor, IUPHAR abstracts, 1990
189.
Inada, T., Rockhold, R. W., Polk, K., Jin, C., Hoskins, B. and Ho, I. K. Effects of cocaine on
dopamine and its metabolites in the striatum between WKY and SHR: a microdialysis study.
Society for Neuroscience Abstracts: 16: 251, 1990.
190.
Makimura, M., Horan, P. J., Hoskins, B. and Ho, I. K. Alterations in opioid receptor binding
following continuous ICV administration of butorphanol and morphine. Society for Neuroscience
Abstracts: 16: 369, 1990.
191.
Yu, Z. J., Huang, M. F., Tharp, K. L., Hoskins, B. Rockhold, R. W. and Ho, I. K. Differential
behavioral responses of Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) after
continuous cocaine infusion. The Toxicologist 11: 116 abs, 1991.
192.
Oh, K. W., Makimura, M., Jaw, S. P., Hoskins, B., and Ho, I. K. Concurrent administration of bfunaltrexamine on butorphanol dependence. FASEB J. 5: A496, 1991.
193.
Jaw, S. P., Makimura, M., Oh, K. W., Hoskins, B. and Ho, I.K. Precipitated withdrawal from
butorphanol by opioid receptor antagonist. FASEB J. 5: A497, 1991.
194.
Miyaoka, T., Kimura, T., Saunders, P. A. and Ho, I. K. Effects of pentobarbital withdrawal on the
benzodiazepine receptor. FASEB J. 5: A499, 1991.
195.
Yu, S., and Ho, I. K. Effects of acute pentobarbital administration on GABAA receptor-regulated
chloride flux in rat brain synaptoneurosomes. FASEB J. 5: A499, 1991.
196.
Saunders, P. A., Miyaoka, T. and Ho, I. K. Ratios as a method of analyzing GABAA receptor
properties. FASEB J. 5: A701, 1991.
197.
Surrett, R. S., Acuff, C. G., Zhang, T. Hoskins, B., Ho, I. K. and Rockhold, R. W. MK-801: an
antagonist of cocaine toxicity in SHR but not WKY. FASEB J: 5: A1034, 1991.
198.
Oden, G., Rockhold, R. W., Ho, I. K. and Farley, J. M. Antagonism of cocaine seizures and death
in mice by excitatory amino acid (EAA) receptor blockers. FASEB 5: A1562, 1991.
199.
Tseng, Y. T., Kimura, T., Hoskins, B., Rockhold, R. W. and Ho, I. K. Chronic nandrolone induces
heart changes and affects brain GABA receptor binding in spontaneously hypertensive (SHR)
and Wistar-Kyoto rats (WKY). Pharmacologist 33: 149, 1991.
49
200.
Jin, C. B., Yu, Z. J., Rockhold, R. W., Hoskins, B. and Ho, I. K. Differential effects of cocaine
receptors between Wistar-Kyoto (WKY) and spontaneously hypertesnive rats (SHR).
Pharmacologist 33: 161, 1991.
201.
Inada, T., Polk, K., Purser, C., Hume, A., Hoskins, B., Ho, I. K. and Rockhold, R. W. Behavioral
and neurochemical responses to continuous infusion of cocaine in rats. Pharmacologist 33:
191, 1991.
202.
Miyaoka, T., Kimura, T., Saunders, P. A. and Ho, I. K. Binding characteristics of [3H]flunitrazepam
in pentobarbital-withdrawal rats. Pharmacologist 33: 192, 1991.
203.
Makimura, M., Oh, K. W., Jaw, S. P., Hoskins, B. and Ho. I. K. Butorphanol dependence and
opioid receptors. Pharmacologist 33: 193, 1991.
204.
Jin, C., Rockhold, R. W., Hoskins, B., and Ho, I. K. Effects of acute cocaine administration on
brain cocaine receptors in Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR).
Toxicologist 12: 320, 1992.
205.
Jaw, S. P., Oh, K. W., Makimura, M., Hoskins, B. and Ho, I. K. Effects of b-funaltrexamine on
naloxone-precipated butorphanol-withdrawal. FASEB J. 6(4): A1574, 1992.
206.
Jaw, S. P., Hoskins, B. and Ho, I. K. The involvement of m and w opioid receptors in butorphanol
dependence. Pharmacologist 34: 210, 1992.
207.
Tseng, Y. T., Miyaoka, T., Yu, S. and Ho, I. K. Region-specific alteractions in [35S] TBPS binding
sites of brain GABAA receptor after tolearance to and dependence upon pentobarbital.
Pharmacologist 34: 210, 1992.
208.
Lim, D. K., Hoskins, B. and Ho, I. K. Changes in the central dopaminergic systems in the
streptozotein-induced diabetic rats. Society for Neuroscience Abstracts 18: 665, 1992.
209.
Jaw, S. P., Hoskins, B. and Ho, I. K. Effects of continuous intracerebroventricular infusion of
butorphanol on kappa opioid receptors. The Toxicologist 13: 217, 1993.
210.
Jaw, S. P., Makimura, M., Hoskins, B. and Ho. I. K. Effects of continuous ICV infusion of
butorphanol on m-, w-, and k- opioid receptors. FASEB J. 7: A705, 1993.
211.
Tseng, Y. T., Miyaoka, T. and Ho, I. K. Region-specific alterations of GABAA receptor bindings by
continuous intracerebroventricular (ICV) infusion of pentobarbital (PB). FASEB J. 7: A31, 1993.
212.
Feng, Y. Z., Tseng, Y. T., Jaw, S. P., Hoskins, B. and Ho, I. K. Tolerance development to
butorphanol: comparison with morphine. FASEB J. 7: A706, 1993.
213.
Tseng, Y. T., Wellman, S. E. and Ho, I. K. Evidence of differential modulation of GABAA receptor
subunit gene expression in pentobarbital-dependent rats by in situ hybridization.
Pharmacologist 35: 137, 1993.
214.
Mamoon, A. M., Ho, I. K. and Hoskins, B. Studies comparing reinforcing properties of
butorphanol (STADOL) and morphine. Pharmacologist 35: 189, 1993.
215.
Feng, Y. Z., Tseng, Y. T., Hoskins, B. and Ho, I. K. Studies of tolerance and cross tolerance to
butorphanol and morphine in rats by continuous ICV infusion. Pharmacologist 35: 189, 1993.
50
216.
Jaw, S. P., Hoskins, B. and Ho, I. K. Comparison of butorphanol withdrawal syndromes
precipitated by opioid receptor antagonists: nor-binaltorphimine (nor-BNI), naltrindole (NTI) and
naloxone (NLX). Soc. Neuroscience Absts. 19: 1246, 1993.
217.
Couch, D. B., Ho, I. K., and Farley, J. M. Changes in intracellular calcium in mouse splenic Tlymphocytes attached to coverslips. FASEB J. 8; 681, 1994.
218.
Feng, Y. Z., Zhang, T., Rockhold, R. W., and Ho, I. K. Naloxone-precipitated morphine
withdrawal increases pontine glutamate levels in the rat. FASEB J. 8: 380, 1994.
219.
Ito, T., Bennett, J. G., Lawson, K., Wellman, S. E. and Ho, I. K. An autoradiography study on t[35S]butylbicyclophosphorothionate (TBPS) binding in the brain of rats made tolerant to and
dependent on pentobarbital (PB): a rapid screening method using phosphor imager . FASEB
J. 8: 381, 1994.
220.
Mamoon, A. M., Barnes, A. M., Ho, I. K., and Hoskins, B. Involvement of M opioid receptors in
butorphanol (Stadol)-induced conditioned place preference. FASEB J. 8: 380, 1994.
221.
Narita, M., Makimura, M., Feng, Y. Z., Hoskins, B., and Ho, I. K. Influence of chronic opioid
treatment on protein kinase C activity in rat brain. FASEB J. 8: 379, 1994.
222.
Zhang, T., Feng, Y. Z., Rockhold, R. W., and Ho, I. K. Naloxone-precipitated morphine
withdrawal and glutamate release in butorphanol dependent rat. FASEB J. 8: 380, 1994.
223.
Ho, I. K., Feng, Y. Z., Zhang, T., and Rockhold, R. W. Naloxone-precipitated opioid withdrawal
and glutamate (Glu): A microdialysis study. Can. J. Physiol. Pharmacol. 72: 347, 1994.
224.
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Choi, J., Couch, D. B., Ho, I. K. and Farley, J. M. Measurement of changes in intracellular
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Lim, D. K., Ito, T., and Ho, I. K. Different responses to N-methyl-D-asparate and kainic acid in
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Suzuki, T., Yamamoto, T., Abe, S., Hori, T., Moroji, T., Shiraishi, H., Ito, T., and Ho, I. K.
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Ito, T., Suzuki, T., Lim, D. K., and Ho, I. K. An in situ hybridization study on 6 subunit mRNA of
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Suzuki, T., Ito, T., Lim, D. K., Wellman, S. E., and Ho, I. K. An autoradiographic study on
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Ito, T., Suzuki, T., Wellman, S. E. and Ho, I. K. Role of -aminobutyric acidA (GABAA) receptors in
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Tokuyama, S., Wakabayashi, H. and Ho, I. K. A protein kinase inhibitor, H-7, blocks naloxone
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Ito, T., Suzuki, T., Wellman, S. E. and Ho, I. K. Possible alterations in [35S]t-butylbicyclophosphorothionate (TBPS) binding after in vitro phosphorylation of GABAA receptor: An
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Lim, D. K., Ma, T. and Ho, I. K. Changes in -aminobutyric acid (GABA) and N-methyl-Daspartate (NMDA) receptors in rats after chronic lead-exposure. The International Congress of
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Kimura, T., Miki, M., Watanabe, K., Kondo, S., Ho, I. K. and Yamamoto, I. Localization of uridine
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Ma, T., Chen, H. S. and Ho, I. K. Effects of lead on [3H]MK-801 binding to NMDA receptor in the
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Wongchanapai, W., Tsang, B. K., He, Z., Eichhorn, J. H. and Ho, I. K. The spinal antinociceptive
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Ma, T., Chen, H.-H., Cheng, H. L., Hume, A. S. and Ho, I. K. Effects of chronic lead exposure on
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254.
Liu, N., Rockhold, R. W. and Ho, I. K. Induced stereotyped behaviors in rats by electric
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Ho, I. K. Excitatory amino acids in butorphanol dependence. 7th SCBA International Symposium,
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Jang, C.-G., Oh, S. and Ho, I. K. Continuous intracerebroventricular (i.c.v.) infusion of
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262.
Ma, T., Jang, C.-G., Chen, H.-H. and Ho, I. K. Effects of lead on [3H]MK-801 binding and NMDA
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He, Z., Tsang, B. K., Wongchanapai, W., Jang, C.-G., Ma, T., Ho, I. K. and Eichhorn, J. H.
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Ho, I. K., Feng, Y. Z., Tokuyama, S., Wakabayashi, H., Zhu, H. and Rockhold, R. W. Glutamate
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Watanabe, K., Kimura, T., Kondo, S., Tsuji, A., Ho, I. K. and Yamamoto, I. Distribution of uridine
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Jang, C.-G., Rockhold, R. W. and Ho, I. K. Time course of [3H]forskolin to adenylate cyclase and
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Tanaka, S., Yoshida, T. and Ho, I. K. Changes in expression of heat shock proteins and AP-1
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Jang, C.-G. Park, Y., Rockhold, R. W. and Ho, I. K. Withdrawal from butorphanol dependence
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Oh, S., Jang. C.-G., Ma, T. and Ho, I. K. Activation of protein kinase C by phorbol dibutyrate
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Nakai, T., Polk, K., Ho, I. K. and Rockhold, R. W. Circulatory and body temperature responses
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Farley, J. M., Zhu, H., Rockhold, R. W., Baker, R. C., Kramer, R. E. and Ho, I. K. In vivo and in
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284.
Smith, J. K., Baker, R. C., Berry, C. S., Ho, I. K., Kramer, R. E., Lister, A. E., Muntaz, M. M.,
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Baker, R. C., Couch, D. B., Farley, J. M., Hume, A. S., Kramer, R. E., Rockhold, R. W., Wellman,
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Zhu, H., Rockhold, R. W., Baker, R. C., Farley, J. M., Kramer, R. E. and Ho, I. K. Effects of single
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Ma, T. and Ho, I. K. Effects of divalent cations on [3H]MK-801 binding to the N-methyl-Daspartate (NMDA) receptor of rat brain. Toxicologist 54: 82, 2000.
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Ma, T., Chen, H.-H. and Ho, I. K. Effects of chronic lead (Pb) exposure on [35S]TBPS binding in
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Chen, H.-H., Ma, T. and Ho, I. K. Effects of developmental lead exposure on inhibitorty avoidance
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Jang, C.-G., Park, Y., Tanaka, S., Ma, T., Loh, H. H. and Ho, I. K. Loss of -opioid receptor gene
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Fan, L.-W., Tanaka, S., Rockhold, R. W. and Ho, I. K. Changes in [3H]bremazocine binding to
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299.
Ma, T., Chen, H.-H. and Ho, I. K. Effects of chronic lead (Pb) exposure on [35S]TBPS binding in
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300.
Ma, T., Sun, T., Baker, R. C., Kramer, R. E., Rockhold, R. W., Farley, J. M. and Ho, I. K. Effects
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Ma, T., Cai, Z., Wellman, S.E. and Ho, I.K. A quick and quantitative histochemistry. The 9th
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Fan, L.W., Tanaka, S., Sasaki, K., Tien, L.-T., Ma, T., Rockhold, R.W. and Ho, I.K.
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Tanaka, S., Fan, L.-W., Sasaki, K., Tien, L.-T., Ma, T., Rockhold, R.W., Yoshida, T. and Ho, I.K.
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Ma, T., Sun, T., Baker, R.C., Kramer, R.E., Rockhold, R.W., Farley, J.M. and Ho, I.K. Effects of
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Ma, T., Sun, T., Baker, R.C., Kramer, R.E., Rockhold, R.W., Farley, J.M. and Ho, I.K. Effects of
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Sogawa, C.A., Sasaki, K., L.-W Fan, Chudaponse, N., Sogawa, N., Ma, T., Rockhold, R.W. and
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Chudapongse, N., Sogawa, C.A., Sasaki, K., Fan, L.-W., Ma, T. and Ho, I.K. Changes in
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Oh, S., Kim, Y.H., Lee, S.Y. and Ho, I.K. Modulation of NMDA receptor and subunit mRNA
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Tien, L.-T., Fan, L.-R., Sogawa, C., Ma, T., Loh, H.H. and Ho, I.K. Changes in M1 and M2
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Jang, C.-G., Yoo, J.-H., Yang, E.-M., Lee, S.Y., Loh, H.H. and Ho, I.K. Differential effects of
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Fan, L.-R., Sasaki, K., Tien, L.-T., Tanaka, S., Sogawa, C., Ma, T., Rockhold, R.W. and Ho, I.K.
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Ma, T., Baker, R.C., Kramer, R.E., Fan, L.W. and Ho, I.K. Effects of chronic dermal exposure to
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Sun, T., Ma., T. and Ho, I.K. Modulation of muscarinic receptors in the rat brain during
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Ochiai, A., Ma, T. and Ho, I.K. Methamphtamine (MAP)-inducedanxiolytic activity in mu-opioid
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Tien, L., Park, Y., Fan, L., Ma, T., Loh, H. and Ho, I.K. Increased dopamine D2 receptor binding
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Kim, S., Chudapongse, N., Lee, S., Levin, M. and Ho, I.K. Protemomic analysis of the frontal
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Jang, C., Yoo, J., Kim, K., Lee, S., Loh, H.H. and Ho, I.K. Attenuation of nicotine-induced
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Ma., T., Sun, T., Baker, R.C., Kramer, R.E. and Ho, I.K. Effects of chronic dermal exposure to
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Sun, T., Paul, I.A. and Ho, I.K. Motor functions but not acquisition and retention of active
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Tien, L.-T., Ochiai, A., Rockhold, R.W., Loh, H.H., Ho, I.K. and Ma, T. Effects of acute
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Chiu, C.-T., Ma, T. and Ho, I.K. Attenuation of methamphetamine-induced behavioral
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Ma, T., Tien, L.-T., Loh, H.H., Rockhold, R.W. and Ho, I.K. Effects of repeated
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Tien, L.-T., Ho, I.K., Loh, H.H. and Ma, T. Dopamine- and muscarinic-stimulated [35S]GTP S
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Chiu, C.-T., Ma, T. and Ho, I.K. Methamphetamine-induced behavioral sensitization in mice:
alterations in -opioid receptors. FASEB J. 20: 430.7, 2006.
332.
Dai x., Brunson C.D., Tafor S., Loh H.H., Ho I.K., Ma T. Gabapentin enhances antinociceptive
activity of and attenuates antinociceptive tolerance to tramadol. American Society of
Anesthesiologists, Annual Meeting, San Francisco, CA, October 13-17, 2007.
333.
Lin L.C., Hwang L.L., Lee H.J., Chen C.T., Lee T. L., Ho I.K., Chiou L.C. Proteomic study of the
hippocampus in high-fat diet induces obese mice. Soc. Neurosci. Abstr. 30: 155.1, 2007.
334.
Tien L.T., Ho I.K., Loh H.H., Ma T. Role of μ-opioid receptor in modulation of immediate-early
gene zif268 mRNA expression in methamphetamine-sensitized mice. Soc. Neurosci. Abstr. 30:
911.3, 2007.
335.
Ma T., Shen X., Tien L.T., Paul I.A., Loh H.H., Ho I.K. Comparison of methamphetamine,
cocaine, and apomorphine-induced behavioral sensitizationl in mu-opioid receptor knockout
mice. Society of Toxicology, 47th Annual Meeting,Seattle, WA, March 16-20, 2008.
58
Patent:
"Use of -ketoglutaric acid to antagonize cyanide poisoning" in the USA with A. S. Hume, J. C. Norris and
S. J. Moore.
Patent Applied:
"N3-Benzyluridine as hypnotic agent" in Japan with I. Yamamoto, T. Kimura, Y. Tateoka and K. Watanabe.
INVITED PARTICIPANT IN SYMPOSIA AND CONFERENCES
I. K. Ho, H. H. Loh, S. Stoleman and E. L. Way. Role of biogenic amines in morphine tolerance and
dependence. Symposium on Agonist and Antagonist Actions of Narcotic Analgesic Drugs,
Aberdeen, Scotland, July 12-13, 1971.
E. L. Way, I. K. Ho and H. H. Loh. Some biochemical aspects of morphine tolerance and physical
dependence, Fourth International Meeting of the International Society for Neurochemistry, Tokyo,
Japan, August 26-31, 1973.
I. K. Ho. Assessment of biochemical mechanisms of drug tolerance and dependence, Neurobiology
seminar, Taipei, Taiwan, China, Sept. 5, 1973. Sponsored by National Science Council, Republic of
China with the support of National Science Foundation, USA and the Asian Foundation.
I. K. Ho, H. H. Loh, H. Bhargava and E. L. Way. Cyclic AMP effects on morphine tolerance and physical
dependence development. The International Narcotic Research Conference, Airlie House, Virginia,
May 21-24, 1975.
I. K. Ho, Annual Meeting of Pharmaceutical Manufacturers' Association Foundation, New York City, New
York, Dec. 1-2, 1974.
I. K. Ho, Annual Meeting of Pharmaceutical Manufacturers' Association Foundation, New York, New York,
Dec. 1-2, 1975.
I. K. Ho, Catecholamine sensitive ATPase in central nervous system. Annual Meeting of Pharmaceutical
Manufacturers' Association Foundation, New York, New York, Dec. 5-6, 1976.
I. K. Ho, Effects of continuous morphine administration on liver functions. Annual Meeting of
Pharmaceutical Manufacturers' Association Foundation, New York, New York, Dec. 4-5, 1977.
I. K. Ho, Fourth International Catecholamine Symposium, Pacific Grove, California, Sept. 17-22, 1978.
I. K. Ho and D. Desaiah. Catecholamine sensitive ATPases in the brain. 4th International Catecholamine
Symposium, Pacific Grove, CA, Sept. 17-22, 1978.
D. Desaiah, I. K. Ho and H. M. Mehendale. Possible molecular mechanism of Kepone- and mirex-induced
hepatobiliary dysfunction. Symposium in Environmental Biology, Muzaffarnagar, India, October 5-11,
1978.
I. K. Ho. Development of tolerance to barbiturate. 12th Annual Winter Conference on Brain Research,
Sun Valley, Idaho, Jan. 20-27, 1979.
I. K. Ho. Co-organizer of a symposium on barbiturate tolerance and dependence for 1979 Fall Meeting of
American Society for Pharmacology and Experimental Therapeutics, Portland Oregon, August, 1979.
I. K. Ho. Effects of acute and chronic administration of pentobarbital on GABA system. International
Symposium on GABA and other Inhibitory Neurotransmitters, Myrtle Beach, SC, Nov. 6-10, 1979.
59
I. K. Ho. Neurochemical evaluation of chlordecone toxicity. Symposium on Molecular Mechanism(s) of
Toxicity of Chlordecone (Kepone) at 1980 Fall Meeting of American Society of Pharmacology and
Therapeutics, Rochester, MN. August 17-21, 1980.
I. K. Ho. Cross-tolerance between narcotics and barbiturate, Workshop on Morphine Tolerance, Midwest
Pharmacology Society, Chicago, IL, June 3-5, 1981.
I. K. Ho. Effects of pentobarbital on GABA system. International workshop on Neuropharmacology,
Taiwan, Republic of China, July 15-17, 1981.
I. K. Ho. Effects of marihuana use. Millsaps College Friday Forum Series, Jackson, Ms. Sept. 18, 1981.
T. Nabeshima, T. Kameyama and I. K. Ho. Tolerance development to chronic administration of
phencyclidine. Tenth Symposium on Pharmacological Activity and Mechanism. Maebashi, Japan,
Oct. 29-30, 1981.
I. K. Ho. Dopaminergic system in cholordecone induced neurotoxicity in mice. International Conference
on Neurotoxicity of Selected Chemicals: Lead. Tin Manganese Kepone. Chicago, Illinois, Sept. 2024, 1982.
T. Nabeshima, T. Kameyama, S. P. Sivam and I. K. Ho. Mechanism of tolerance development to
pentobarbital in relation to GABAergic neuronal and dispositional functions in mice. The 11th
Symposium on Pharmacological Activity and Mechanism, Sendai, Japan, Oct. 26-27, 1982.
I. K. Ho. Phencyclidine and GABA system. Satellite Symposium on "Cellular and Molecular Basis of
Neurotoxicity of Environmental Agents", Third International Congress on Toxicology, San Diego, CA,
Aug. 26-27, 1983.
I. K. Ho. Striatal dopamine--aminobutyric acid-acetylcholine interaction in organophosphate-induced
neurotoxicity. International Conference on Dynamics of Cholinergic Function. Oglebay Park, West
Virginia, Oct. 30 - Nov. 4, 1983.
I. K. Ho. Dopamine-GABA-acetylcholine interaction in organophosphate induced toxicity. Symposium on:
Mechanism of Drug Toxicity and Its Antagonism. Twenty-seventh Annual Meeting of Western
Pharmacology Society. Reno, Nevada, Jan. 30 - Feb. 3, 1984.
I. K. Ho. Aspects of tolerance development to organophosphorus cholinesterase inhibitors. Seminars on
Environmental Toxicology. Taipei, Republic of China, March 26 - April 2, 1985.
I. K. Ho. Mechanism of tolerance development to organophosphorus cholinesterase inhibitors. Third
Annual Symposium on Environmental Toxicology and Pathology: Mechanisms of Neurotoxicity.
Northwestern University Medical School in Chicago. Chicago, Ill., May 2, 1985.
I. K. Ho. Basal ganglia dopamine-gamma-aminobutyric acid-acetylcholine interaction in organophosphateinduced neurotoxicity. Review and Analysis of the Medical Chemical Defense Program. United
States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD., March
4, 1986.
I. K. Ho. Organizer. Conference on pharmacokinetics and toxicology with regard to drug use among the
elderly. First Annual Research and Education Conference of the Mississippi Geriatric Education
Center. Biloxi, MS., March 24, 1986.
I. K. Ho. Organizer. Symposium on Organophosphates and Non-Cholinergic Systems. 1986 American
Society of Pharmacology and Experimental Therapeutic - Society of Toxicology Meeting, Baltimore,
MD. August 17-21, 1986.
60
I. K. Ho. Neuropharmacological aspects of cocaine ingestion. Symposium on Cocaine: Contemporary
Issues in Research, Testing and Abuse. Annual Meeting of the Mississippi Academy of Sciences.
Feb. 26-27, 1987.
I. K. Ho. Toxicology, pharmacokinetics in the geriatric patient. American College of Physicians LouisianaMississippi Chapters 1987 Scientific Meeting. New Orleans, LA. Jan. 23, 1987.
I. K. Ho. Pharmacologic and toxicologic approach to the detection of toxic substances in food and drugs.
Workshop on the Science and Technology of Food and Drug Safety. Sponsored by Food and Drug
Bureau, Republic of China. Taipei, Republic of China, June 2-6, 1987.
I. K. Ho. Involvement of the central dopaminergic and GABAergic systems in organophosphateneurotoxicity. Symposium on Toxicology Research. Sponsored by Academia Sinica, Republic of
China. Taipei, Republic of China, December 17-19, 1987.
I. K. Ho. Aspects in neurotoxicology testing. Toxicology Conference, sponsored by National Institute for
Environmental Studies of Japan, Tsukuba, Japan, June 12-13, 1990.
I. K. Ho. Gamma-aminobutyric acid and neurotoxicity. Conference on Toxicology, sponsored by the
National Science Council of the Republic of China and National Taiwan University, Taipei, Taiwan,
Republic of China, June 18-19, 1990.
I. K. Ho. Pre-synaptic and post-synaptic cholinergic receptors in organophosphate neurotoxicity.
Workshop on Toxicology, sponsored by Chang-Gung Medical College, Taiwan, Republic of China,
June 20, 1990.
I. K. Ho. Gamma-aminobutyric acid and neurotoxicity, Third SCBA International Symposium and
Workshop, Hong-Kong, June 24-30, 1990.
I. K. Ho. Effects of ginsenosides on GABAA and GABAB receptors. The International Symposium on
Korean Ginseng, sponsored by the Society for Korean Ginseng, Seoul, Korea, July 20-21, 1990.
I. K. Ho. Organizer and Speaker. Toxicology: Mechanism, detoxification and risk management. Fourth
International Symposium and Workshop of Society of Chinese Bioscientists in America, Singapore,
June 14 -19, 1992.
I. K. Ho. Sedative-Hypnotics: Addiction and current research status. Symposium on Drug and Food
Analysis in Public Health Services, sponsored by National Laboratories of Foods and Drugs,
Department of Health, Republic of China, Taipei, Republic of China, September 20-21, 1993.
I. K. Ho and S. E. Wellman. Barbiturates and GABAA receptors. XIV Congreso Latinoamericano de
Farmacologia, Santiago, Chile, November 1994.
I. K. Ho, P. Horan, S. P. Jaw, M. Makimura, K. W. Oh, Y. Z. Feng, T. Zhan, R. W. Rockhold and B.
Hoskins. Opioid receptors and glutamate in butorphanol dependence. Symposium on Basic and
Clinical Research on Opioids. National Defense Medical Center, Taipei, Republic of China,
December 17-18, 1994.
I. K. Ho. Organizer and Speaker. Neurotoxicology: Past, present, and future. International Environmental
Toxicology Conference, Academia Sinica, Taipei, Republic of China, May 29-31, 1995.
I. K. Ho. GABA receptor and barbiturates. Sixth SCBA International Symposium, Vancouver, Canada,
June 24-29, 1995.
61
I. K. Ho. Glutamate and opioid dependence. Symposium on Basic Research on Opioids. National
Defense Medical Center, Taipei, Taiwan, Republic of China, January 13, 1996.
I. K. Ho. Barbiturates: From chemistry to biological functions. Professor Tung-Bin Lo’s Retirement
Symposium. The Institute of Biological Chemistry, Academic Sinica, Taipei, Taiwan, Republic of
China, February 18, 1997.
I. K. Ho. Glutamate in dependence upon kappa-opioid agonists. Symposium on Clinical and Basic
Research on Opioids. National Defense Medical Center, Taipei, Taiwan, Republic of China, April 2627, 1997.
I. K. Ho. Glutamate in opioid dependence. Symposium on Brain Plasticity and Drug Dependence, 23rd
Conference on Medicine and Biology of the Brain, Nagoya, Japan, June 28, 1997.
I. K. Ho. Excitatory amino acids and lead-induced neurotoxicity. Symposium on Neurotoxicology: from
Molecules to Whole Animals. The 1st International Conference of Asian Society of Toxicology,
Yokohama, Japan, June 29-July 2, 1997.
I. K. Ho, Excitatory amino acids in butorphanol dependence. Symposium on Neurotransmitters: from
Gene to Behavior. 7th SCBA International Symposium, Toronto, Canada, July 6-11, 1997.
I. K. Ho, Opioid- and NMDA-receptors in opioid dependence. Symposium of the 1996 Elected Members
of Academia Sinica, Taipei, Taiwan, July 4, 1998.
I. K. Ho, The nucleus paragigantocellaris and opioid withdrawal-like behaviors. 2nd US-Taiwan
Neuroscience Symposium on Opioid and Opioid Receptors. Miami Beach, FL, October 23, 1999.
I. K. Ho, The N-methyl-D-aspartate receptor in opioid dependence. Symposium on Drug Tolerance,
Dependence and Abuse II. 8th Southeast Asian-Western Pacific Regional Meeting of
Pharmacologists, Taipei, Taiwan, November 1-5, 1999.
I. K. Ho, Glutamate in Opioid Dependence. Symposium on Receptors and Ion Channels as Targets for
Drug Addiction. The 1st Annual Symposium of The Basic Research Center on the Molecular & Cell
Biology of Drug Addiction, Minneapolis, MN, May 12-13, 2000.
I. K. Ho, N-Methyl-D-aspartate receptors in opioid dependence and withdrawal. Symposium on
Catecholamine and Addictions, 9th International Catecholamine Symposium, Kyoto, Japan, April 2,
2001.
I. K. Ho, Kappa-opioid agonists and physical dependence. 23rd Annual Southeastern Pharmacology
Society Meeting, “Drugs in the Mountains”, The East Tennessee State University James H. Quillen
College of Medicine, Department of Pharmacology and the Office of Continuing Medical Education,
October 18, 2002.
I. K. Ho, Kappa-opioid receptors in butorphanol dependence. National Defense Medical Center
Symposium, National Health Research Institute, Taipei, Taiwan, November 5, 2002.
I. K. Ho, Kappa-opioid receptor in physical dependence on opioids, Special Lecture, First International
Symposium of Neurobehavioral Pharmacology, Okayama, Japan, September 14, 2003 .
I. K. Ho, Alterations of neurotransmitter systems in -opioid receptor knockout mice, Plenary Lecture,
Annual Meeting of Taiwan Society of Neuroscience, Taipei, Taiwan, October 4, 2003.
I. K. Ho, Grant writing and review processes in the U.S., Tenth International Symposium of Chinese
Bioscientists in America, Beijing, China, July 19, 2004.
62
I. K. Ho, Neurochemical alterations in physical dependence on opioids, Symposium on Neuroprotection
and Neuroprotective Drugs, The Korean Society of Applied Pharmacology, Seoul, Korea.
November 11, 2004.
I. K. Ho, Depndence on butorphanol, a kappa-opioid agonist. The 80th Annual Scientific Meeting of the
Japanese Pharmacological Society, Nagoya, Japan. March 17, 2007
I. K. Ho, Mu-opioid Receptor in Methamphetamine-induced Behavioral Sensitization. The 26th Annual
Meeting of Japanese Association of Forensic Toxicology, Kyushu University, Kyushu, Japan. June 7,
2007.
I. K. Ho, Drug misue, abuse,and addiction, the Wu-Ta-You Science Camp, Shin-Tou, Taiwan. August 13,
2007
I.K. Ho, A genetic enginnered animal model may not be as simple as one believes, The 50th Auunal
Symposium of National Research Institute of Chinese Medicine, Taiwan, November 24, 2007.
I.K. Ho, Drug misuse, abuse, and addiction, The 2nd National Chengchi University Taipei Model United
Nations, Taiwan, May 31, 2008.
I.K. Ho, The importance of toxicology in drug development, 2008 Forum for Cooperation and Technique
exchanging on Chinese Medicine, Taiwan, December 17, 2008.
63
SEMINARS GIVEN
Pharmacology Department, University of California, San Francisco, April 25, 1973. Topic:
Pharmacological manipulations of morphine tolerance and physical dependence.
Pharmacology Department, University of California, San Francisco, May 21, 1974. Topic: Barbiturate
tolerance: An animal model.
Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, Sept. 31,
1974. Topic: Pellet implantation as a model for studying the biochemical mechanisms of tolerance
and physical dependence on morphine and barbiturates.
Taipei Medical College, Taipei, China, July 8, 1976. Topic: Amino acid neurotransmitters and their CNS
function.
Taipei Jen-Ai Hospital, Taipei, China, July 19, 1976. Topic: Drug interactions: Narcotic and sedativehypnotics.
Institute of Pharmacology, School of Medicine, National Taiwan University, July 17, 1976. Topic: An
animal model for studying barbiturate tolerance and physical dependence.
Institute of Biological Chemistry, Academia Sinica, July 31, 1976. Topic: Amino acid neurotransmitters
and their CNS functions.
Department of Pharmacology, University of California, San Francisco, CA, August 1976. Topic:
Catecholamine sensitive ATPase in central nervous system.
Department of Pharmacology and Department of Medicinal Chemistry, School of Pharmacy, The
University of Mississippi, Sept. 21, 1976. Topic: Drug interactions: Narcotic and sedative-hypnotic
agents.
Department of Pharmacology, Cornell University Medical College, New York, New York, Dec. 1976.
Topic: An animal model for assessing barbiturate tolerance.
Department of Cell Biology, Baylor College of Medicine, Houston, Texas, May 1977. Topic: An animal
model for assessing barbiturate tolerance.
Department of Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, May
1977. Topic: Effects of continuous morphine administration on mouse liver.
Department of Anesthesiology, The University of Texas Health Science Center at Houston, Houston, TX,
March 29, 1978. Topic: Drug interactions: barbiturates-narcotics.
Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, April 25, 1978.
Topic: Effects of continuous administration of morphine on hepatic functions.
McNeil Laboratories, Fort Washington, PA, May 25, 1978. Topic: Catecholamine sensitive ATPase
system and its possible involvement in neuronal function.
Sinclair Comparative Medicine Research Farm and Department of Pharmacology, University of Missouri,
Columbia, MO, May 26, 1978. Topic: Catecholamine sensitive ATPase system and its possible
involvement in neuronal function.
C. H. Boehringer Sohn, Ingelheim am Rhein, Germany, July 10, 1978. Topic: Effects of morphine on
hepatic functions.
64
Department of Pharmacology, Howard University School of Medicine, Washington, D. C., November 15,
1978. Topic: An animal model for studying barbiturate tolerance and physical dependence.
Department of Pharmacology, Medical College of Ohio, Toledo, OH, October 4, 1979. Topic:
Biochemical aspects of barbiturate tolerance and dependence.
Department of Public Health, Veterinary School, Texas A & M University, October 15, 1980. Topic:
Comparative toxicity of chlordecone, mirex and photomirex.
Research Institute for Socio-Technical Problems, Jackson State University, Jackson, MS, March 17, 1981.
Topic: Interactions of drugs of abuse.
Minority Biomedical Support Program, Jackson State University, Jackson, MS, March 26, 1981. Topic:
Comparative toxicity of mirex and Kepone.
Department of Medical Pharmacology, School of Medicine, Texas A & M University, May 11, 1981. Topic:
Effects of barbiturate on GABA system.
Department of Pharmacology. Medical College of Wisconsin, June 3, 1981. Topic: Comparative toxicity
of chlordecone, mirex and photomirex.
Chung-Shan Institute of Science and Technology, Republic of China,July 16, 1981. Topic: Mechanisms
of chlordecone induced neurotoxicity.
Japanese National Institute of Hygienic Sciences, Tokyo, Japan, July 20, 1981. Topic: Biochemical basis
of barbiturate tolerance and dependence.
Department of Hygienic Sciences, School of Pharmacy, Hokuriku University, Kanazawa, Japan, July 31,
1981. Topic: Comparative toxicology of mirex, photomirex and chlordecone.
Department of Pharmacology, Toyama Medical and Pharmaceutical University, Toyama, Japan, August 1,
1981. Topic: Biochemical basis of barbiturate tolerance and dependence.
Department of Chemical Pharmacology, School of Pharmacy, Meijo University Nagoya, Japan, August 3,
1981. Topic: GABA system in barbiturate action.
Department of Pharmacology, School of Medicine, University of Nebraska, Omaha, Nebraska, Jan. 10,
1983. Topic: Aspects of barbiturate tolerance and dependence.
MARC Program, Jackson State University, Jackson, MS, April 21, 1983. Topic: Organophosphate
induced neurotoxicity.
Department of Pharmacology, University of California, San Francisco, San Francisco, Calif. Aug. 31,
1983. Topic: Diisopropylfluorophosphate induced neurotoxicity.
Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical
Sciences, Little Rock, AK, March 14, 1984. Topic: Neurotransmitter interactions in organophosphate
induced tolerance.
Department of Medicine, Veterans General Hospital, Republic of China, Taipei, Taiwan, April 2, 1985.
Topic: Acetylcholine and dopamine interaction in organophosphate induced neurotoxicity.
Department of Pharmacodynamics, College of Pharmacy, University of Illinois, Chicago, Ill., May 3, 1985.
Topic: Mechanisms of tolerance development to organophosphates.
65
Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth, Texas, August 26,
1985. Topic: Tolerance development to organophosphates.
R. J. Reynolds Industries, Winston-Salem, NC, September 4, 1985. Topic: Aspects of nicotine
dependence.
Department of Biological Sciences, Mississippi State University, Starkville, MS, October 4, 1985. Topic:
Mechanisms of tolerance development to organophosphates.
Neuroscience Program, University of Alabama, School of Medicine, Birmingham, Al, June 24, 1986.
Topic: Mechanisms of tolerance development to organophosphates.
Department of Chemical Pharmacology, College of Pharmacy, Meijo University, Nagoya, Japan, July 26,
1986. Topic: Neurotransmitter interactions in organophosphate induced tolerance.
Department of Pharmacology, School of Medicine, Okayama University, Okayama, Japan, July 29, 1986.
Topic: Mechanisms of tolerance development to organophosphates.
School of Pharmacy, Hokuriku University, Kanazawa, Japan, July 30, 1986. Topic: Tolerance to
organophosphate cholinesterase inhibitors.
Workshop on Minority Biomedical Research, Jackson State University, August, 13, 1986. Topic:
Neurotransmitter interactions in organophosphate induced tolerance.
Department of Pharmacology, School of Medicine, University of Missouri, Columbia, MO, April 27, 1987.
Topic: Non-cholinergic aspects of organophosphate tolerance.
Department of Medicine, Veterans General Hospital, Republic of China, Taipai, Taiwan, June 3, 1987.
Topic: Pharmacokinetics in geriatric patients.
Department of Pharmacology, School of Medicine, University of South Alabama, Mobile, Alabama,
October 26, 1987. Topic: Neurotransmitter interaction in organophosphate induced toxicity.
Pharmacology Division, U. S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving
Ground, MD, November 9, 1987. Topic: Prevention of organophosphate toxicity after continuous
administration of physostigmine.
Chung Shan Institute of Science and Technology, Lung-Tan, Taiwan, Republic of China, December 15,
1987. Topic: Mechanism of action of organophosphates.
U. S. Army Aeromedical Research Laboratory, Department of the Army, Fort Rucker, AL, April 22, 1988.
Topic: Symptomatic signs of OP intoxication and protection with carbamate pretreatment.
Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL,
May 19, 1988. Topic: Regulation of GABAA receptors by pharmacological agents.
School of Pharmaceutical Sciences, Showa University, Tokyo, Japan, November 26, 1988. Topic:
Regulation of GABAA receptors by pharmacological agents.
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, November 30, 1988. Topic:
Pharmacologic and toxicologic approach to the detection of toxic substances in food and drugs.
The Graduate Division, Fukuoka University, Fukuoka, Japan, December 1, 1988. Topic: Barbiturate and
GABA system.
66
Medical and Development Division, Nippon Boehringer Ingelheim Co., Kawanishi, Hyogo, Japan,
December 6, 1988. Topic: Pharmacology of sedative-hypnotics.
Department of Hygienic Chemistry, School of Pharmacy, Hokuriku University, Kanazawa, Japan,
December 13, 1988. Topic: Cocaine and neurochemical changes in SHR and WKY rats.
School of Pharmacy, Hokuriku University, Kanazawa, Japan, December 15, 1988. Topic: Regulation of
GABAA receptors by pharmacological agents.
Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan, December 19, 1988. Topic:
Pharmacokinetics in geriatric patients.
Department of Pharmacy, College of Science and Technology, Nihon University, Tokyo, Japan.
December 23, 1988. Topic: Biochemical basis of neuropharmacology.
Division of Sciences, Tougaloo College, Jackson, MS. April 10, 1989. Topic: Contemporary drug abuse.
Department of Pharmacology, School of Medicine, University of Minnesota, Minneapolis, MN. November
27, 1989. Topic: Aspects of GABA system.
Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A&M University,
College Station, TX. February 6, 1990. Topic: Regulation of GABAA receptors by pharmacological
agents.
National Institute of Safety Research, Ministry of Health and Social Affairs. Seoul, Korea, July 24, 1990.
Topic: Barbiturate and GABA system.
College of Pharmacy, Chonnam National University, Cheoung-Ju, Korea, July 26, 1990. Topic:
Regulation of GABAA receptors by pharmacological agents.
Institute of Industrial Health, China North Industries Group, Xian, China. October 20, 1990. Topic:
Biochemical basis for neurotoxicity.
National Center for Toxicology Research, Pine Bluff, AR.. November 30, 1990. Topic: Neurotransmitter
interactions in organophosphate tolerance.
Department of Pharmacology, School of Medicine, National Taiwan University, Taipei, Republic of China,
March 18, 1991. Topic: Spontaneously hypertensive and Wistar-Kyoto rats: A model system for
analysis for cocaine pharmacodynamics.
Chang Gung Memorial Hospital, Taipei, Republic of China, March 21, 1991. Topic: Contemporary drug
abuse.
Airforce General Hospital, Taipei, Republic of China. March 25, 1991. Topic: Biochemical basis of
neuropharmacology.
Tokyo Medical University, Tokyo, Japan, June 5, 1991. Topic: Barbiturates and GABA receptors.
College of Pharmacy. Nihon University, Chiba, Japan, June 6, 1991. Topic: Contemporary drug abuse.
College of Dentistry, Nihon University, Tokyo, Japan, June 10, 1991. Topic: Use of opioid analgesics in
dentistry.
College of Pharmacy, Chiba University, Chiba, Japan, June 12, 1991. Topic: Neurotransmitter
interactions in organophosphate-induced tolerance.
67
Daiichi Seiyaku Company, Tokyo, Japan, June 13, 1991. Topic: Regulation of GABAA receptors by
pharmacological agents.
Department of Medical Microbiology and Immunology, School of Medicine, University of South Florida,
Tampa, FL. December 6, 1991. Topic: Spontaneously hypertensive and Wistar-Kyoto rats: a model
system for analysis of cocaine pharmacodynamics.
Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, Ill. March 23,
1992. Topic: Spontaneously hypertensive and Wistar-Kyoto rats: a model system for analysis of
cocaine pharmacodynamices.
Pesticide and Environmental Toxicology Section, California Environmental Protection Agency Berkeley,
CA., April 24, 1992. Topics: Neurotoxicity testing of chemicals.
Department of Pharmacology, National Defense Medical College, Taipei, Taiwan, Republic of China.
June 9, 1992. Topic: Barbiturates on GABA system: comparison to alcohol and benzodiazepines.
Center for Occupational Health, Kaohsuing Medical College, Kaohsuing, Taiwan, Republic of China.
August 13, 1992. Topic: Mechanism of organophosphate tolerance.
Department of Industrial and Environmental Health, National Cheng Kung University Medical College,
Taiwan, Taiwan, Republic of China. August 14, 1992. Topic: Neurotransmitter interactions in
organophosphate-induced tolerance.
Departments of Anesthesia and Critical Care and Pharmacological and Physiological Sciences. The
University of Chicago. Chicago, Ill. February 10, 1993. Topic: The effects of barbiturates on the
GABA system.
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan. July 26, 1993.
Topic: Barbiturates and GABAA receptors.
Pharmaceutical Research Center, Meiji Seika Kaisha, Yokohama, Japan. July 27, 1993. Topic:
Pharmacology of antipsychotics and antidepressants.
Department of Pharmacology, Naitonal Cheng Kong University Medical School, Tainan, Taiwan.
September 23, 1993. Topic: Barbiturates and GABAA receptors.
Chang Gung Memorial Hospital at Kaohsuing, Kaohsuing, Taiwan, Sepember 24, 1993. Topic:
Neurotoxicity of drugs and chemicals.
Departments of Neurology and Occupational Health, Kaohsuing Medical College, Kaohsuing, Taiwan.
September 24, 1993. Topic: Barbiturates and GABA system.
Department of Medical Pharmacology and Toxicology, School of Medicine, Texas A&M University, College
Station, Texas. March 1, 1994. Topic: GABAA receptors and barbiturate dependence.
National Laboratories of Foods and Drugs, Department of Health, Republic of China, Taipei, Taiwan,
September 16, 1994. Topic: Addiction to opioid analgesics.
Chang Gung College of Medicine and Technology, Tao-Yuan, Taiwan, November 7, 1994. Topic:
Barbiturates and GABAA receptors.
Taipei Medical College, Taipei, Taiwan, December 16. 1994.Taipei: Topic GABA system in barbiturate
dependence.
68
Niigata College of Pharmacy, Niigata, Japan. March 22, 1995. Topic: Mechanisms of butorphanol
dependence.
National Center of Neurology and Psychiatry, Tokyo, Japan. March 24, 1995. Topic: Opioid receptors
and excitatory amino acids in opioid dependence.
Narcotic Bureau, Department of Health, Republic of China, Taipei, Taiwan. January 11, 1996. Topic:
Contemporary drug abuse.
Narcotic Bureau, Department of Health, Republic of China, Taipei, Taiwan. January 11, 1996. Topic:
Mechanism of action - CNS depressants.
Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan. April 1, 1996. Topic: Mechanism
of action - CNS depressants.
College of Pharmacy, Chonnam National University, Kwangju, Korea. April 22, 1996. Topic: Mechanism
of action - CNS depressants.
College of Pharmacy, Chungbuk National University, Cheongju, Korea. April 23, 1996. Topic: Glutamic
acid in opioid dependence.
Pharmaceutical Screening Research Team, Korea Research Institute of Chemical Technology, Taejeon,
Korea, April 25, 1996. Topic: Opioid receptors and excitatory amino acids in opioid dependence.
Department of Pharmacology, Hokkaido Institute of Pharmaceutical Sciences, Otaru, Japan. June 10,
1996. Topic: Glutamate and butorphanol dependence.
Division of Drug Metabolism Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
June 11, 1996. Topic: Barbiturates and GABAA receptors.
Department of Environmental Health, Colorado State University, Fort Collins, CO. September 16, 1996.
Topic: Non-cholinergic aspects of tolerance to organophosphorus cholinesterase inhibitors.
National Laboratories of Foods and Drugs, Department of Health, Taipei, Taiwan. April 18, 1997. Topic:
Glutamate and opioid dependence.
Department of Chemistry, National Taiwan University, Taipei, Taiwan. April 21, 1997. Topic:
Barbiturates: from chemistry to biological function.
Veterans General Hospital-Taichung, Taichung, Taiwan. April 24, 1997. Topic: Non-cholinergic aspects
of tolerance to organophosphorous cholinesterase inhibitors.
Institute of Toxicology, Chung-Shan Medical College, Taichung, Taiwan. April 24, 1997. Topic:
Toxicology in biomedical sciences.
College of Life Sciences, Yang-Ming University, Taipei, Taiwan. April 25, 1997. Topic: GABAA receptors
in barbiturate dependence.
National Narcotics Bureau, Department of Health, Republic of Health, Taipei, Taiwan. November 13,
1997. Topic: Butorphanol tolerance and dependence.
Mississippi Chapter of the Society for Neuroscience, Jackson, Mississippi. December 2, 1997. Topic:
Glutamate and opioid dependence.
Taipei Medical College, Taipei, Taiwan. May 24, 1999. Topic: Spinal opioid receptors in the development
of tolerance to and dependence on intrathecal butorphanol.
69
Department of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, LA.
October 5, 1999. Topic: Glutamate and opioid dependence.
Safety Evaluation Institute, Eisai Company, Gifu, Japan. March 27, 2000. Topic: Toxicokinetics of methyl
parathion after oral and dermal exposure.
Department of Pharmacology, National Defense Medical Center, May 23, 2000. Topic: NMDA receptors
in morphine dependence.
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, June 26,
2000. Topic: Glutamate in opioid dependence.
Department of Neuropsychopharmacology, National Nagoya University, School of Medicine, April 6, 2001.
Topic: Dependence on -opioid receptor agonists.
Dahan Technology College, Hualein, Taiwan, December 17, 2001. Topic: Aspects of drugs of abuse.
Hokuriku University, Kanazawa, Japan, February 9, 2002. Topic: Action mechanism of barbiturates and
their tolerance development.
Kyushu University of Health and Welfare, School of Pharmaceutical Sciences, Miyazaki, Japan,
September 12, 2003. Topic: Alterations of neurotransmitter system in -opioid receptor knockout
mice.
National Cheng Kung University School of Medicine, Tainan, Taiwan, October 6, 2003. Topic: Kappaopioid receptors in physical dependence on opioid analgesics.
Department of Pharmacology, China Medical University, Taichung, Taiwan, March 1, 2004. Topic: Kappa
opioid receptor in opioid dependence.
University Hospital, China Medical University, Taichung, Taiwan, March 3, 2004. Topic: Drugs of abuse.
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Japan,
September 12, 2003, Topic: Alterations of neurotransmitter systems in -opioid receptor knockout
mice.
National Cheng-kung University College of Medicine, Taipei, Taiwan, October 6, 2003. Topic: Kappaopioid receptors in physical dependence on opioid analgesics.
China Medical University, Taichung, Taiwan, March 1, 2004. Topic: Kappa opioid receptor in opioid
dependence.
China Medical University Hospital, Taichung, Taiwan, March 3, 2004. Topic: Drugs of abuse.
College of Medicine, National Taiwan University, Taipei, Taiwan, November 8, 2004. Topic: Glutamate
and opioid receptors in opioid dependence.
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan, March 9, 2005. Topic: Neurochemical
alterations in physical dependence on opioids.
Biomedical Engineering Center, Industrial and Technology Research Institute, Shin-Tzu, Taiwan, April 28,
2005. Topic: Neurochemical alterations in physical dependence on opioids.
College of Medicine, Tzu-Chi Medical University, Hualien, Taiwan, April 29, 2005. Topic: Drugs of abuse.
70
National Bureau of Controlled Drugs, Department of Health, Taipei, Taiwan, June 2, 2005.
Butorphanol abuse.
Topic:
Chung Shan Medical University, Taichung, Taiwan, Nov. 11, 2006. Topic: Chemistry,biomistry,
biochemistry, and pharmacology in study of opioid.
National Bureau of Controlled Drugs, Department of Health, Taipei, Taiwan, April 18, 2007. Topic:
Chemistry, biomistry, biochemistry, and pharmacology in study of opioid
Institute of Occupational Medicine and Industrial Hygene, National Taiwan University, Taipei, Taiwan, May
7, 2007. Topic: A career Path in Toxicology.
Division of Medicinal Chemistry, National Research Institute of Chinese Medicine, Taipei, Taiwan, May 9,
2007. Topic: Chemistry, biomistry, biochemistry, and pharmacology in study of opioid.
Taipei Medical University, Taipei, Taiwan, June 5, 2007. Topic: Dependence on Butorphanol, a kapaopioid agonist.
School of Medicine, Fu Jen Catholic University, Taipei, Taiwan, June 6, 2007. Topic: Dependence on
butorphanol, a kapa-opioid agonist.
Chang Gung University, Tao Yuan, Taiwan, October 5, 2007. Topic: Chemistry, biomistry, biochemistry,
and pharmacology in study of opioid.
Bali Psychiatric Center, Department of Health, Taiwan, November 22, 2007. Topic: Mu-opioid Receptor in
Methamphetamine-induced Behavioral Sensitization.
Department of Health, Taiwan, August 14, 2008. Topic: Methadone and Morphine.
E-DA Hospital, Kauhsiung, Taiwan, September 13, 2008. Topic: Drug Misuse, Abuse and Addition.
School of Medicine, Fu Jen Catholic University, October 22, 2008. Topic: Drug Misuse, Abuse and
Addition.
China Medical University, Taiwan, January 17, 2009. Topic: Methadone and Morphine.
71
MAJOR INVITED ADDRESSES
July 16, 1976, Annual Meeting of Chinese Association of Pharmacy, Taipei. Topic: Drug interactions:
Narcotics and sedative-hypnotics.
July 30, 1976, Chinese Biochemical Society, Taipei. Topic: Catecholamine sensitive ATPase in central
nervous system.
September 17, 1977, Mississippi Society for Neuroscience, Jackson, MS. Topic: Catecholaminesensitive ATPases in the CNS and possible roles in morphine action.
May 10, 1985, South Central Regional Meeting of Society of Toxicology. Jackson, MS. Topic: Aspects of
organophosphate tolerance.
December 4, 1988, Annual Meeting of Kyushu Branch of the Pharmaceutical Society of Japan, Fukuoka,
Japan. Topic: Regulation of GABA receptors by pharmacologic agents.
June 13, 1990, Seventeenth Annual Meeting of Japanese Society of Toxicological Sciences, Nagoya,
Japan. Topic: Gamma-aminobutyric acid and neurotoxicology.
June 3, 1991, the 84th Kanto Regional Meeting of the Japanese Society of Pharmacology, Tokyo, Japan.
Topic: Spontaneously hypertensive and Wistar-Kyoto rats: a model system for analysis of cocaine
pharmacodynamics.
June 7, 1991, the 731th Meeting of the Keio Medical Society, Tokyo, Japan. Topic: Effects of barbiturates
on GABA system: Comparison to alcohol and benzodiazepines.
July 30, 1993. 20th Annual Meeting of Japanese Society of Toxicological Sciences, Chiba, Japan. Topic:
Neurotoxicity of drugs and chemicals: Present and future perspectives.
March 20, 1995. 68th Annual Meeting of the Japanese Pharmacological Society, Nagoya, Japan. Topic:
Role of -aminobutyric acidA (GABAA) receptors in drugs of abuse.
January 5, 1996. Inauguration of National Health Research Institutes, Republic of China, Taipei, Taiwan.
Topic: Future perspectives in environmental and occupational health.
March 29, 1996. 116th Annual Meeting of the Pharmaceutical Society of Japan, Kanazawa, Japan.
Topic: Opioid receptors and excitatory amino acids in opioid dependence.
April 19, 1996. Annual Meeting of the Korean Society of Applied Pharmacology, Seoul, Korea. Topic:
Opioid receptors and excitatory amino acids in opioid dependence.
June 8, 1996. The 89th Kanto Regional Meeting of the Japanese Society of Pharmacology. Tokyo,
Japan. Topic: Non-cholinergic aspects of tolerance to organophosphorus cholinesterase inhibitors.
November 18, 1996. American Chinese Society of Neuroscience. Washington, D.C. Topic:
Neurotoxicology in neuroscience.
March 10, 1997. American Chinese Toxicology Society. Cincinnati, OH. Topic: Biomedical sciences in
toxicology.
April 19-20, 1997. Plenary Lecturer. Taiwan Society of Toxicology Annual Meeting, Taipei, Taiwan,
Republic of China. Topic: Neurotoxicology: from the whole animal to molecules.
November 29, 1997. 1997 MCA/AACP Winter Conference, Vicksburg, Mississippi. Topic: Opiates:
Therapeutics and abuse.
72
March 25, 2000. Hokuriku Branch of Japanese Biochemical Society and Hokuriku Branch of
Pharmaceutical Society of Japan joint lecture. Topic: Glutamate in opioid dependence.
June 2, 2001, Annual Meeting of the Chinese Medical Association, Taipei, Taiwan, Republic of China.
Topic: Pharmacokinetics and pharmacodynamics of methyl parathion.
February 9, 2002. Upon the retirement of Professor Ikuo Yamamoto, Kanazawa, Japan. Topic: Action
mechanisms of barbiturates and their tolerance development.
September 15, 2003, International Symposium of Neurobehavioral Pharmacology, Okayama University
Graduate School of Medicine and Dentistry, Okayama, Japan. Topic: Kappa-opioid receptors in
physical dependence on opioids.
October 4, 2003, 2003 Annual Meeting of Neuroscience Society, ROC (Taiwan). Topic: Alteration of
neurotransmitter systems in -opioid receptor (MOR) knockout mice.
December 16, 2006, Auunal Meeting of the Toxicology Society of Taiwan. Topic: A Career Path in
Toxicology.
Mach 17, 2007, International Symposium: Basic and Clinical Research for Appropriate Use of Medicine,
Nogoya, Japan. Topic: Dependence on Burotphanol, A KAPA-Opioid Agonist.
June 7-9, 2007, The 26th Annual Meeting of Japanese Association of Forensic Toxicology, Miyazaki,
Japan. Topic: Mu-opioid Receptor in Methamphetamine-induced Behavioral Sensitization.
73
CHAIRMANSHIPS
Chairperson, Drug Abuse II, 60th Annual Meeting of Federation of American Societies for Experimental
Biology, Anaheim, CA, April 11-16, 1976.
Chairperson, Drug Abuse II. 1976 Fall Meeting of American Society for Pharmacology and Experimental
Therapeutics, Aug. 1976, New Orleans, LA.
Chairperson, Analgesics, 1978 Fall Meeting of American Society for Pharmacology and Experimental
Therapeutics and Society of Toxicology, August 13-17, 1978, Houston, Texas.
Chairperson, Symposium on Barbiturate Tolerance and Physical Dependence. 1979 Fall meeting of
American Society for Pharmacology and Experimental Therapeutics, Aug. 19-23, 1979, Portland,
Oregon.
Chairperson, Depressants. 64th Annual Meeting of Federation of American Societies for Experimental
Biology, Anaheim, California, April 14-18, 1980.
Chairperson, Neurobiology and Behavior, 65th Annual Meeting of Federation of American Societies for
Experimental Biology, Atlanta, GA, April 12-17, 1981.
Co-Chairman, International Workshop on Neuropharmacology, Taipei, Taiwan, Republic of China, July
15-17, 1981.
Co-Chairman, Biochemical Toxicology I. 1982 Annual meeting of Society of Toxicology, February 20-23,
1982.
Co-Chairman, Cholinergic Pharmacology II. 69th Annual Meeting of Federation of American Societies for
Experimental Biology, Anaheim, CA, April 22-26, 1985.
Co-Chairman, Pharmacy and Biology Session. Workshop on the Science and Technology of Food and
Drug Safety. Organized by Food and Drug Bureau, Republic of China, Taipei, Taiwan, Republic of
China, June 2-6, 1987.
Co-Chairman, Satellite Symposium in honor and recognition of the accomplishments of Dr. E. Leong Way
on Advances in Opioid Mechanisms, 1987. Annual Meeting of American Society for Pharmacology
and Experimental Therapeutics, Honolulu, Hawaii, Aug. 15-19, 1987.
Co-Chairman, Symposium on Neuroscience Research. Symposium on Recent Advances in Biological
and Medical Sciences, sponsored by Academia Sinica, Republic of China. Taipei, Taiwan, Republic of
China, December 17-19, 1987.
Co-Chairman, Drug Abuse II, 73rd Annual Meeting of the Federation of American Societies for
Experimental Biology, New Orleans, Louisiana, March 19-23, 1989.
Co-Chairman, Toxicology: Mechanism, Detoxification and Risk Management, Fourth International
Symposium and Workshop of Society of Chinese Bioscientists in America. Singapore, June 14-19,
1992.
Co-Chairman, Symposium on Neurotoxicology: from Molecules to the Whole Animal. The 1st
International Conference of Asian Society of Toxicology, Yokohama, Japan, June 29-July 2, 1997.
Co-Chairman, Symposium on Drug Tolerance, Dependence and Abuse I. 8th Southeast Asian-Western
Pacific Regional Meeting of Pharmacologists, Taipei, Taiwan, November 1-5, 1999.
74
Co-Chairman, Symposium on Catecholamines and Addiction. 9th International Catecholamine
Symposium, Kyoto, Japan, April 1-5, 2001.
Organizer, The 9th SCBA International Symposium, Frontiers of Biotechnology and Biomedical Science in
the New Millennium, August 6-10, 2001.
Chairman, Professor E. Leong Way Birthday Symposium, Peripherally Acting Opioid Receptor
Antagonists. San Francisco, California, July 10, 2005
75
Past Training Experience
1.
Post graduate trainees
I. Yamamoto, Ph.D., Professor and Vice President
Department of Hygienic Chemistry
School of Pharmaceutical Sciences
Kyushu University of Health and Welfare
Miyazaki, 882-8508 Japan
A. Takanaka, Ph.D., Professor Emeritas
Showa University School of Pharmacy
Tokyo, Japan
Diane C. Lin, Ph.D., Professor
Department of Biochemistry
University of California, Irvine
Irvine, California
S. F. Tzeng, Ph.D., Assistant Research Biochemist
Department of Dermatology
University of California, San Francisco
San Francisco, California 84143
Jean Fu, M.D., Post Graduate Research Pharmacologist
Department of Pharmacology
University of California, San Francisco
San Francisco, California 84143
K. Onoda, Ph.D., Section Chief
Department Pharmacology
National Institute of Hygienic Sciences
Tokyo, Japan
(now deceased)
D. Desaiah, Ph.D., Professor
Department of Neurology
University of Mississippi Medical Center
Jackson, MS
K. Fujimori, Ph.D., Section Chief
Department of Pharmacology
National Institute of Hygienic Sciences
Tokyo, Japan (retired)
T. Nabeshima, Ph.D., Professor and Director
Department of Neuropsychopharmacology and Hospital Pharmacy
Nagoya University Graduate School of Medicine
Nagoya 466, Japan
B. A. Flint, Ph.D., D.D.S., M.D.
Medical/Dental Practice
Sparta, Tennessee
76
S. P. Sivam, Ph.D.,
Professor and Course Director of Pharmacology and Toxicology
Indiana University School of Medicine - Northwest Campus
3400 Broadway
Gary, IN 46408
John Fernando, Ph.D., Research Associate
Department of Pharmacology and Experimental Therapeutics
University of Maryland School of Medicine
655 W. Baltimore Street
Baltimore, MD 21201
Hiroshi Watanabe, Ph.D., Manager
Tokkyo-bu
Meiji Seika Kaisha, Ltd.
4-16, Kyobashi 2-Chome
Chuo-Ku, Tokyo 104, Japan
Y. Ito, Ph.D., Professor
Research Unit of Pharmacology
Department of Clinical Pharmacy
College of Pharmacy, Nihon University
7-7-1 Narashinodai
Funabashi 274-8555, Japan
Eiko Ueno, Ph.D., Research Associate
School of Pharmacy
University of Connecticut
U. Box 92
372 Fairfield Road
Storrs, Connecticut 06268
D. K. Lim, Ph.D., Professor
College of Pharmacy
Chonnam National University
300 Yong-Bong Dong, Book Gu
Kwang-Ju, Korea 500-757
Y. Ishizuka, Ph.D., Manager
Pharmaceutical Research and Development
NISSHO Corp.
2-32-4, Shinzaike Settsu-City
Osaka 566, Japan
T. Kimura, Ph.D.
Department of Hygienic Chemistry
Faculty of Pharmaceutical Sciences
Hokuriku University
Kanazawa, Japan
M. F. Huang, M.D. Associate Professor
Institute of Occupational Medicine
Chinese Acad. of Preventive Medicine
29 Nan Wei Road
Beijing, PR China
77
Mizue Makimura, Ph.D., Associate Professor and
Director of Hospital Pharmacy
Nihon University School of Medicine
Department of Pharmacology and Hospital Pharmacy
30-1 Kamimachi, Oyaguchi
Igabashi-Ku, Tokyo 173, Japan
Ki-Wan Oh, Ph.D.
Professor of Pharmacology
Department of Pharmacy
College of Pharmacy
Chungbuk National University
12, Gaeshin-Dong, Cheongju 361-763, Korea
Toshiya Inada, M.D.
National Institute of Mental Health
1-7-3, Konodai, Ichikawa-Shi
Chiba 272, Japan
Boqin Lu, M.D., Professor
Institute of Occupational Medicine
Chinese Academy of Preventive Medicine
29 Nan Wei Road
Beijing, Peoples Republic of China
Teiji Miyaoka, Ph.D.
Daiichi Pure Chemicals Co. Ltd.
2117 Muramatsu Tokai-mura
Naka-gun, Ibaraki 319-11, Japan
Changbae Jin, Ph.D.
Principal Research Scientist
Bioanalysis & Biotransformation Research Center
Korean Institute of Science and Technology
P.O. Box 131
Cheongryang, Seoul 130-650, Korea
Minoru Narita, Ph.D., Assistant Professor
Hoshi University
Tokyo, Japan
Yang-Zheng Feng, M.D., Research Associate
Department of Pediatrics
University of Mississippi Medical Center
Jackson, Mississippi 39216
Toshihito Suzuki, M.D., Associate Professor
Department of Psychiatry
Juntendo Koshigaya Hospital
Juntendo University School of Medicine
560 Fukuroyama, Koshigaya
Saitama 343-0032, Japan
78
Hiroyuki Wakabayashi, Ph.D., Professor
Department of Clinical Pharmacotherpy
Niigata School of Pharmacy and Applied Life Sciences
5-13-2 Kamishinei-cho
Niigata 950-21, Japan
Takehiko Ito, M.D., Ph.D.
Department of Nursing
Faculty of Education
Okayama University
3-1-1 Tushimo-naka
Okayama City 700, Japan
Shogo Tokuyama, Ph.D., Professor
Dept. Clinical Pharmacy
School of Pharmaceutical Science
Showa University
1-5-8 Hatanodai, Shinagawa-ku
Tokyo 142-8555, Japan
Katsuji Hoshi, Ph.D., Professor
Hikkaido Institute of Pharmaceutical Sciences
7-1 Katsuraoka-cho
Otaru 047-02
Hokkaido, Japan
Seikwan Oh, Ph.D., Associate Professor
College of Medicine
Ewha Womans University
Mok-6-dong, Yangeheon-ku
Seoul, 158-056, Korea
Toru Nakai, Ph.D.
Private Pharmacy Practice
Otaru, Hokkaido, Japan
Kenroh Sasaki, Ph.D.
Tohoku Pharmaceutical University
4-1 Komatsushima 4-chome, Aobaku
Sendai 981-8558, Japan
Choon-Gon Jang, Ph.D., Assistant Professor
Department of Pharmacology, School of Medicine
Hallym University
OK-Cheon Dong
Chunchon, Kang-Wan-Do, Korea
Sachiko Tanaka, Ph.D. Assistant Professor
Showa University
School of Pharmaceutical Sciences
Department of Biochemical Toxicology
1-5-8 Hatanodai, Shinagawa-ku
Tokyo 142 Japan
79
Chiharu Sogawa, Ph.D., Instructor
Department of Dental Pharmacology
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
2-5-1 Shikata-cho, 2-chome
Okayama 700-8525, Japan
Akira Ochiai, Ph.D.
Biomedical Engineering Center
Toin University of Yokohama
1614 Kurogone-cyo Aoba-ku
Yokohama, Kanagawa 225-8502, Japan
Yuh-Fung Chen, Ph.D. Associate Professor
China Medical University
91, Hsueh-Shih Rd.
Taichung 404, Taiwan
Lu-Tai Tien, Ph.D.
Department of Medicine
School of Medicine
Fu Jen Catholic University
510 Chung Cheng Road, Hsinchuang
Taipei Hsien 24205, Taiwan
Kuo-Cheng Lan, M.D.
Department of Emergency Medicine
Tri-Service General Hospital
No. 325, Sec. 2, Cheng-Kung Road
Neihu 114, Taipei, Taiwan
2.
Major thesis advisor for Ph.D. candiates
Bryan A. Flint, Ph.D., D.D.S., M.D. (Degree awarded in June 1979)
Private Medical/Dental Practice
Sparta, Tennessee
Jerrel Fontenot, Ph.D., M.D. (Degree awarded October 1981)
Private Medical Practice
Monroe, Louisiana 71201
Helen V. C. Benet, Ph.D. (Degree awarded May, 1983)
Intelligence Officer
DIA/TWP-4
Building 1607
Ft. Detrick, Maryland 21701
James C. Norris, Ph.D. (Degree awarded May, 1983)
Plant Manager, Toxicology Assessment
Charles River Company
Redfield, AR
D. K. Lim, Ph.D. (Degree awarded July, 1986)
Professor
College of Pharmacy
Chonnam National University
300 Yong-Bong Dong, Book Gu
Kwang-Ju, Korea 500-757
80
Marland D. Dulaney, Ph.D. (Degree awarded July, 1987)
Dulaney Toxicology, Inc.
7133 Heritage Ridge Road
Tallahassee, Florida 32312
Peter Horan, Ph.D. (Degree awarded May 1990)
Pharmacist
46 Golf Cottage Dr.
Naples, FL 34105
Paul Saunders, Ph. D. (Degree awarded December, 1990)
Investigator
R&D Systems
614 McKinley Place
Minneapolis, MN 55413
Zhu-Jian Yu, M.D., Ph.D. (Degree awarded July, 1991)
Private Medical Practice
Jacksonville, FL
Sue Yu, Ph.D. (Degree awarded May, 1992)
Research Associate
Department of Biochemistry
University of Missouri Medical Center
Columbia, MO
Shyhwen Peter Jaw, Ph.D. (Degree awarded May, 1993)
20 Northern Pine Loop
Aliso Viego, CA 92656
Yi-Tang Tseng, Ph.D. (Degree awarded May 1994)
Associate Professor (Research)
Department of Pediatrics
Women and Infant Hospital of Rhode Island
Brown University
Providence, RI 02905-2401
Seikwan Oh, Ph.D. (Degree awarded May 1995)
Associate Professor
College of Medicine, Ewha Womans University
Mok-6-dong, Yangeheon-ku
Seoul, 158-056, Korea
Hwei-Hsien Chen, Ph.D. (Degree awarded May 1998)
Professor
Department of Life Science
Tzu-Chi College of Medicine
701, Section 3, Chung Yang Road
Hualien 970, Taiwan
Wichai Wongchanapai, M.D., L.L.B., Ph.D. (Degree awarded May 1998)
Assistant Professor
Faculty of Medicine Siriraj Hospital
Mahidol University
2 Prannok Rd., Bangkoknoi
Bangkok 10700, Thailand
81
Hong Zhu, M.D., Ph.D. (Degree awarded February 1999)
Assistant Professor
Department of Otolarynology and Communicative Science
University of Mississippi Medical Center
Jackson, MS 39216
Lir-Wan Fan, Ph.D. (Degree awarded August 2002)
Postdoctoral Fellow
Department of Pediatrics
University of Mississippi Medical Center
Jackson, MS 39216
Nuannoi Chudapongse, Ph.D. (Degree awarded May 2003)
Instructor
Institute of Science
Suranaree University of Technology
111 University Avenue
Nakhon Ratchasima 30000
Thailand
Tingting Sun, Ph.D. (Degree awarded May 2004)
Postdoctoral Fellow
Neurology Research/114-2001
Massachusetts General Hospital
114 16th St.
Charlestown, MA 02129-4404
Lu-Tai Tien, Ph.D. (Degree awarded May 2004)
Department of Medicine
School of Medicine
Fu Jen Catholic University
510 Chung Cheng Road, Hsinchuang
Taipei Hsien 24205, Taiwan
Seong Youl Kim, Ph.D. (Degree awarded August 2004)
Research Fellow
Department of Pharmacology
Mayo Clinic Foundation
200 First St. SW
Rochester, MN 55905
Chi-Tso Chiu (current student)
Department of Pharmacology and Toxicology
3.
Major thesis advisor for M.S. candidates
Ms. Diana Huang, M.S. (Degree awarded December 1980)
Toxicologist, Institute of Food and Drug Inspection
Taipei, Taiwan
Republic of China
Mr. Greg Ritchie, M.S. (Degree awarded May, 1982)
Naval Intelligence Support Center
4301 Suitland Road
Washington, D. C. 20390-5140
82
Ms. Savitha M. Rao, M.S. (Degree awarded May, 1994)
Senior Biologist
Microbiological Associate
(Home: No. 4 Swan Stream Court)
Gaithersburg, Maryland 20877
4.
Thesis Advisory Committee member for:
R. Parker, Ph.D. (Degree awarded June 1979)
Department of Physiology
Sharon A. Watson, Ph.D. (Degree awarded June 1980)
Department of Pharmacology and Toxicology
Linda S. Angevine, Ph.D. (Degree awarded August 1981)
Department of Pharmacology and Toxicology
Scott Klingensmith (Degree awarded May 1982)
Department of Pharmacology and Toxicology
Yahya Nasir Khawaji, M.D., Ph.D. (Degree awarded August 1982)
Department of Anatomy
Steven J. Moore, Ph.D. (Degree awarded July 1986)
Department of Pharmacology and Toxicology
Andrea N. Bell, Ph.D. (Degree awarded July 1986)
Department of Pharmacology and Toxicology.
Chuen-Mao Yang, Ph.D. (Degree awarded May 1987)
Department of Pharmacology and Toxicology.
D. D. Liu, Ph.D. (Degree awarded May 1988)
Department of Pharmacology and Toxicology.
Caroline K. Burton, Ph.D. (Degree awarded May 1990)
Department of Pharmacology and Toxicology
Changbae Jin, Ph.D. (Degree awarded May 1990)
Department of Pharmacology and Toxicology
Jaeyang Kong, Ph.D. (Degree awarded May 1990)
Department of Pharmacology and Toxicology
William S. Utley, Ph.D. (Degree awarded May 1990)
Department of Pharmacology and Toxicology
Hsiu-Ming Huang Saunders, Ph.D. (Degree awarded December 1990)
Department of Pharmacology and Toxicology
Char-Chang Shieh, Ph.D. (Degree awarded January 1992)
Department of Pharmacology and Toxicology
Cory G. Acuff, Ph.D. (Degree awarded November 1995)
Department of Pharmacology and Toxicology
83
Satin G. Sawant, Ph.D. (Degree awarded November 1995)
Department of Pharmacology and Toxicology
Cathy Winter, Ph.D. (Degree awarded November 1995)
Department of Pharmacology and Toxicology
A. M. Mamoon, Ph.D. (Degree awarded May 1996)
Department of Pharmacology and Toxicology
Shoumin Zhu, M.D., Ph.D. (Degree awarded May 1996)
Department of Pharmacology and Toxicology
Xibao Liu, M.D., Ph.D. (Degree awarded May 1996)
Department of Pharmacology and Toxicology
Ming Huan Chan, Ph.D. (Degree awarded August 1997)
Department of Pharmacology and Toxicology
Lingen Lu, M.D., Ph.D. (Degree awarded August 1997)
Department of Pharmacology and Toxicology
Duan Su, M.Sc. (Degree awarded September 1997)
Department of Pharmacology and Toxicology
Jae-Hwa Choi, Ph.D. (Degree awarded May 1998)
Department of Pharmacology and Toxicology
Niansen Liu, M.D., Ph.D. (Degree awarded August 1998)
Department of Pharmacology and Toxicology
Kristin Sonntag Wilcox, Ph.D. (Degree awarded May 1999)
Department of Pharmacology and Toxicology
Chia-Yu Chang, Ph.D. (Degree awarded February 2000)
Department of Pharmacology and Toxicology
Weilie Zhang, M.D., Ph.D. (Degree awarded May 2000)
Department of Pharmacology and Toxicology
Buyean Lee, Ph.D. (Degree awarded August 2000)
Department of Pharmacology and Toxicology
Younjoo Park, Ph.D. (Degree awarded June 2001)
Department of Pharmacology
National Seoul University
Jen-Tsung Hsieh, Ph.D. (Degree awarded February 2002)
Department of Pharmacology and Toxicology
Robert Preston Jones, Ph.D. (Degree awarded December 2002)
Department of Pharmacology and Toxicology
Kiranam Chatti, Ph.D. (Degree awarded December 2004)
Department of Pharmacology and Toxicology
84
Sunmee Wee (Degree awarded May 2005)
Department of Pharmacology and Toxicology