EU Funded Research Project
Partner Search Form
Date: 7-6-2007
Deadline: 18 september 2007
Contact
Organization
Al-Azhar university
Department
Contact
person
Dr. Mohamed Abdelghaffar Ashour
Email
M_aashor@yahoo.com
Address
Pharmacognosy Dept.
Faculty Of Pharmacy
Alazhar university (Boys)
Nasr city
Cairo
Egypt
Postcode
Country
Telephone
Pharmacognosy and medicinal plants
City
Cairo
Egypt
002-022-4401142
002-011-1381474
Fax
Website
Familiar with the European Framework Programme?  YES
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PROJECT
Title: Bioprospecting for drug leads
Project
type
Status
Call
Reference.
Priorities
’ Main
Research
Areas
Topic
from the
work
program
Acronym: HEALTH-2007-2.3.4-3:
Large-scale integrating
collaborative project
Small or medium-scale focused research
collaborative project
SICA collaborative project
Network of Excellence
Coordination and Support Action
Research for the benefit of SMEs
Other (Marie Curie Actions, ERANET…)
Targeted to SMEs
Planned for submission
FP7-HEALTH-2007-B
HEALTH-2007-2.3.4-3: Bioprospecting for drug leads.
Abstract
Keywords
The project includes Extraction, bioactivity guided fractionation, isolation and
purification of natural products from Egyptian natural sources (terrestrial and
marine). Followed by unambiguously structure elucidation. Finally retesting of
the pure active compounds in order to confirm the biological activity of the
isolated natural products. The biological Activity tests includes cytotoxic
activity, antimicrobial activity, anti HIV.
Natural product chemistry, medicinal natural products, cytotoxic,
antimicrobial agents, terrestrial and marine natural sources
1- El-Dondity S.E., Khalifa T.I., Ammar H.A. and Ashour M. (1999)
chemical and biological study of sophora japonica L. growing in Egypt.
Az J. Pharm. Sci., 24: 230-243.
2- Ashour M, Edrada RA, Ebel R, Wray V, Wätjen W, Padmakumar K,
Müller WEG, Lin WH, Proksch P (2006) Kahalalide derivatives from
the indian sacoglossan mollusk Elysia grandifolia. J. Nat. Prod. 69:
1547-1553
3- Hosny M, Johnson HA, Ueltschy AK, Rosazza JP.Oxidation, reduction,
and methylation
of carnosic acid by Nocardia. J Nat Prod. 2002 Sep;65(9):1266-9.
4- Hosny M, Rosazza JP.Novel oxidations of (+)-catechin by horseradish
peroxidase and laccase. J Agric Food Chem. 2002 Sep 25;50(20):553945
5- Hosny M, Rosazza JP.New isoflavone and triterpene glycosides from
soybeans.
J Nat Prod. 2002 Jun;65(6):805-13.
S & T Publications
6- Hosny M, Dhar K, Rosazza JP. Hydroxylations and methylations of
quercetin, fisetin,
and catechin by Streptomyces griseus. J Nat Prod. 2001 Apr;64(4):462-5.
7- Hosny M, Rosazza JP.Novel isoflavone, cinnamic acid, and triterpenoid
glycosides in soybean molasses. J Nat Prod. 1999 Jun;62(6):853-8.
8- Hosny M, Rosazza JP.Gmelinosides A-L, twelve acylated iridoid
glycosides from Gmelina arborea. J Nat Prod. 1998 Jun 26;61(6):73442.
9- Calis I, Hosny M, Khalifa T, Ruedi P.Phenylpropanoid glycosides from
Marrubium
alysson.
Phytochemistry. 1992 Oct;31(10):3624-6.
10- Calis I, Hosny M, Yuruker A, Wright AD, Sticher O.Inerminosides A and
B, two novel complex iridoid glycosides from Clerodendrum inerme. J
Nat Prod. 1994 Apr;57(4):494-500.
11- Hosny M, Khalifa T, Calis I, Wright AD, Sticher O.Balanitoside, a
furostanol glycoside, and 6-methyldiosgenin from Balanites aegyptiaca.
Phytochemistry. 1992 Oct;31(10):3565-9.
Commitment/Work
to be offered
Extraction, bioactivity guided isolation of natural product from Egyptian
natural sources. Structure elucidation for the isolated bioactive natural
products and retesting of the bioactive compounds.
Our team can offer: - rotatory evaporators and associated vacuum pumps.
adsorbents (silica gel, sephadex )
solvents (methanol , DCM, Hexane )
UV Lamps
We can proceed all steps regarding extraction isolation
and structure elucidation of the active constituents in
our lab at the pharmacognosy dept. faculty of pharmacy
Alazhar university.
Egyptian working
Team
-
Dr Mohamed Ashour (Pharmacognosy Dept, Faculty Of
Pharmacy, Alazhar university.)
Prof Dr Mohamed Hosny Hussein (Pharmacognosy Dept,
Faculty of Pharmacy, Alazhar University.)
Partner Sought
Role
technology development
research
training
dissemination
demonstration
other
If another role expected, please specify it here
Country /region
Start of
partnership
Expertise
required
All Countries
start-up phase
mid-term
end-phase
We need other partners to have facilities for measurements regarding NMR
spectroscopy, Mass spectrometry, and Biological evaluation of natural products (e.g.
catatonic activity and antimicrobial activity studies).
I agree with the publication of my data
Please fill-in and return it to:
Egyptian National Scientific & Technical Information Network (ENSTINET)
Health National Contact Point
By email to: fp7@sti.sci.eg
or
By fax. To: (+202) 7947807