Naomi Alvarez
December 2, 2006
R5 - EBM Assignment
EBM QUESTION
In the patient with a cutaneous basal cell carcinoma, would treatment with
imiquimod 5% cream (Aldara) alone as compared to conventional surgical
interventions lead to the same outcome of treatment in terms of recurrence rates,
completion of treatment, and cosmetic outcome?
BIBLIOGRAPHY
(Dr. F. – My plan is to have the annotation part done over Christmas break. For
now, here are the articles that I am using.)
Barnestone, R. St. C., Satchell, A. , Zhuang, L., Slade, H.B., Halliday, G.M. (2004)
Imiquimod induced regression of clinically diagnosed superficial basal cell
carcinoma is associated with early infiltration by CD4 T cells and dendritic cells.
Clinical and Experimental Dermatology, 29, 639-643.
Bianchi, L., Costanzo, A., Campione, E., Nistico, S., and Chimenti, S. (2003)
Superficial and nodular basal cell carcinomas treated with an immune response
modifier: a report of seven patients. Clinical and Experimental Dermatology
28(Suppl. 1), 24-26.
Cowen, Edward, Mercurio, Mary Gail, and Gaspari, Anthony A. (2002) An open case
series of patients with basal cell carcinoma treated with topical 5% imiquimod
cream. Journal of the American Academy of Dermatology, 47(Suppl. 4), S240S248.
Dahl, Mark V. (2002) Imiquimod: A cytokine inducer. Journal of the American
Academy of Dermatology, 47(Suppl. 4), S205-S208.
Geisse, John K., Rich, Phoebe, Pandya, Amit, Gross, Kenneth, Andres, Kara, Ginkel,
Angie, Owens, Mary. (2002) Imiquimod 5% cream for the treatment of
superficial basal cell carcinoma: A double-blind, randomized, vehicle controlled
study. Journal of the American Academy of Dermatology, 47 (3), 390-398.
McCutcheon, Brion, White, Kenneth, Kotwall, Cyrus, Germolic, Dori, Rebollosos,
Yvette, Hamann, Mary Sue, Stiles, Anquonette. (2005) A Preliminary Study of
Imiquimod Treatment in Variants of Basal Cell Carcinoma. The American
Surgeon, 71(8), 662-665.
Mirza, B. and De’Ambrosis, B. (2003) Treatment of facial superficial basal cell
carcinoma with imiquimod 5% cream. Clinical and Experimental Dermatology,
28(Suppl. 1), 16-18.
Oldfield, Vicki, Keating, Gillian M., and Perry, Caroline M. (2005) Imiquimod in
superficial basal cell carcinoma. American Journal of Clinical Dermatology,
6(3), 195-200.
Peris, Ketty, Campione, Elena, Micantonio, Tamara, Marulli, Georgiana Clare, Fargnoli,
Maria Concetta, and Chimenti, Sergio. (2005) Imiquimod Treatment of
Superficial and Nodular Basal Cell Carcinoma: 12-Week Open-Label Trial.
Dermatologic Surgery, 31(3), 318-323.
Persaud, Andrea and Lebwohl, Mark. (2002) Imiquimod cream in the treatment of
actinic keratoses. Journal of the American Academy of Dermatology, 47(Suppl.
4), S236-S239.
Quirk, Chris, Gebauer, Kurt, Owens, Mary, and Stampone, Paul. (2006) Two-year
interim results from a 5-year study evaluating clinical recurrence of superficial
basal cell carcinoma after treatment with imiquimod 5% cream daily for 6 weeks.
Australasian Journal of Dermatology, 47, 258-265.
Salasche, Stuart. (2002) Imiquimod 5% cream: a new treatment option for basal cell
carcinoma. International Journal of Dermatology, 41 (Suppl. 1), 16-20.
Shumack, Stephen, Gebauer, Kurt, Quirk, Chirs, Macdonald, Ken, Walters, Shelley-Ann,
and Owens, Mary. (2004) 5% Imiquimod Cream for the Treatment of Large
Superficial Basal Cell Carcinoma. Archives of Dermatology, 140, 1286-1287.
Shumack, Stephen, Robinson, June, Kossard, Steven, Golitz, Loren, Greenway, Hubert,
Schroeter, Arnold, Andres, Kara, Amies, Mark, Owens, Mary. (2002) Efficacy
of Topical 5% Imiquimod Cream for the Treatment of Nodular Basal Cell
Carcinoma. Archives of Dermatology, 138, 1165-1171.
Schulze, H.J., Cribier, B., Requena, L., Reifenberger, J., Ferrandiz, C., Diez, A. Garcia,
Tebbs, V., and McRae, S. (2005) Imiquimod 5% cream for the treatment of
superficial basal cell carcinoma: results from a randomized vehicle-controlled
phase III study in Europe. British Journal of Dermatology, 152, 939-947.
Spencer, James M. (2006) Pilot Study of Imiquimod 5% Cream as Adjunctive Therapy
to Curettage and Electrodesiccation for Nodular Basal Cell Carcinoma.
Dermatologic Surgery, 32(1), 63-69.
Stulberg, Daniel L., Crandell, Blain, Fawcett, Robert S. (2004) Diagnosis and Treatment
of Basal Cell and Squamous Cell Carcinomas. American Family Physician, 70,
1481-1488.
Vidal, D., Matias-Guiu, X., and Alomar, A. (2004) Open study of the efficacy and
mechanism of action of topical imiquimod in basal cell carcinoma. Clinical and
Experimental Dermatology, 29, 518-525.
Vun, Yin and Siller, Greg. (2006) Use of 5% imiquimod cream in the treatment of facial
basal cell carcinoma: A 3-year retrospective follow up study. Australasian
Journal of Dermatology, 47, 169-171.