2555 Linner Way Regina SK S4V 1K3 Canada Phone (306) 789-1728 Fax (306) 586-3511 E-mail hkamencic@gmail.com Curriculum Vitae of HUSE KAMENCIC, M.D. Obstetrics/Gynecology Current Position Obstetrician/Gynecologist at RQHR (Regina Qu'Appelle Health Region) since 2008 Fellowship Fellow in Minimally Invasive Gynecology, University of Saskatchewan, Regina General Hospital Associate member of Department of Obstetrics and Gynecology, Regina General Hospital 2007/2008 Residency Department of Obstetrics, Gynecology and Reproductive Sciences at the College of Medicine, University of Saskatchewan 2002 to 2007 Previous Positions Postdoctoral Fellow, Department of Anatomy and Cell Biology College of Medicine, University of Saskatchewan 1998 to 2002 Nationality Canadian Citizen Personal Data Languages Summary of Qualifications Place of Birth: Sanski Most, B&H Married to Edita Burazerovic (M.D.) 17-year-old daughter Belma 7-year-old daughter Edina English, German, Bosnian Passed the Royal College Examination for Obstetrics and Gynecology May 2007 (FRCSC) Passed the Medical Council of Canada Evaluating Examination (MCCEE), Part I and Part II (MCCQE I and MCCQE II) 2 Huse Kamencic, M.D. Passed United States Medical Licensing Examination 2 (USMLE 2) Passed the Test of English as a Foreign Language (TOFEL) Full registration with the Medical Council of Bosnia and Herzegovina (B&H) in 1992. Passed the Bosnia and Herzegovina Licensing Examination in February 1992. M.D. University of Sarajevo, Sarajevo, B&H in 1990. Medical College Admission Test (Physics, Chemistry, Biology) University of Sarajevo, Sarajevo, B&H. Registered Nurse (RN) Nursing School Prijedor, B&H in 1984. Appointments 2002-2007 Residency in Obstetrics and Gynecology, Department of Obstetrics, Gynecology and Reproductive Sciences, College of Medicine, University of Saskatchewan, Saskatoon, Canada. 1998-2002 1995-1998 Postdoctoral Fellow, Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Canada. Postdoctoral Fellow, Department of Anatomy and Cell Biology, College of Medicine, University of Heidelberg, Heidelberg, Germany. 1993-1995 Physician, University Hospital, Sarajevo, B&H, Part time Teaching Fellow. 1992 Teaching Fellow, Department of Anatomy, College of Medicine University of Sarajevo, B&H. Education & training 1980-1984 Nursing School Prijedor, B&H. 1984-1985 Military Service, Nurse in the Military Clinical Center Zagreb, Croatia. 1985-1990 2002- M.D. at the College of Medicine, University of Sarajevo, Sarajevo, B&H. Postgraduate training PGY-1, College of Medicine, University of Saskatchewan, Saskatoon, Canada 3 Huse Kamencic, M.D. Professional Experience 1992 Teaching Fellow, Department of Anatomy, College of Medicine, University of Sarajevo, Sarajevo, B&H. I taught and demonstrated gross anatomy and neuroanatomy to first and second year medical and dental students. 1993-1995 Physician, University Hospital, Sarajevo, B&H. 1995-1998 Postdoctoral Fellow, Department of Anatomy and Cell Biology, College of Medicine, University of Heidelberg, Heidelberg, Germany. Research areas: Endometriosis, Laparoscopic hysterectomy, Effect of Essure microinserts for sterilization on menstrual cycle, Postmenopausal cysts, Role of macrophages in hypercholesterolemia, Oxidative stress in cells of immune system, Antigen presenting cells in the heart during high blood cholesterol level, Role of complement system in atherosclerosis, Apoptosis and proliferation, Gene therapy in hepatoma, Radioactive stent implantation and restenosis. Research techniques: Digital image analysis, Immuno/cyto - chemistry, Morphological microscopy, Electron microscopy (ultrastructural), Stent implantation surgical placement of stent in femoral artery), RT-PCR. I participated in teaching gross anatomy, neuroanatomy and histology to first year dental and medical students. 1998-2002 Postdoctoral Fellow, Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Canada. Research areas: Oxidative stress following spinal cord injury, Procysteine compounds administration after spinal trauma, Inflammatory response after spinal injury, Role of glutathione dependent system in stroke, novel techniques for glutathione detection Research techniques: Advanced neurosurgery; clip compression model of spinal cord injury in rat, immuno/cyto - chemistry, protein chemistry (Western blot, measurement of enzymes activity; glutathione reductase, glutathione peroxidase), morphological microscopy, HPLC (high performance liquid chromatography). 4 Huse Kamencic, M.D. AWARDS / MEDALS FIRST PLACE: Jerome J. Hoffman Award, AAGL AWARD Postgraduate Prize Paper on Minimally Invasive Gynecology; Presented at the Global Congress of Minimally Invasive Gynecology at the AAGL 35th Annual Meeting, November 06, 2006, Las Vegas Nevada, Title: Pentoxifylline (Trental) after Conservative Surgery for Endometriosis – A Randomized Controlled Trial. Kamencic H, Brydon L. Differential diagnosis of cystic adnexal masses in periand postmenopausal women. Volume 25, June 2003, Supplement to JOGC. 1st Runner-up Gynecology poster (presented at SOGC 59th Annual Clinical Meeting June 2003, Charlottetown, PEI The Brain Star Award for November 1st, 2001 by the Canadian Institute of Neurosciences, Mental Health and Addiction . Web page: http://www.cihr.ca/institutes/inmha/whatsnew/brainstar_e.shtml) First Poster Prize in Postdoctoral Fellow competition the 7th Student Research Day, University of Saskatchewan, Saskatoon, January 21, 2000 Fellowship from HSURC Saskatchewan Fellowship from College of Medicine, University of Saskatchewan Fellowship from German Academic Foreign Service 1995/1996 The Golden Badge of the University of Sarajevo, Sarajevo, B&H (with Great Distinction, graduated with an average grade 9.70 [out of possible 10.00]) Studentship for 1998/1999 from the University of Sarajevo, Sarajevo, B&H Internal Medicine Award “Dr. Bogdan Zimonjic”, from the College of Medicine, University of Sarajevo, Sarajevo, B&H PROFESSIONAL AFFILIATIONS ▪ Saskatchewan College of Physicians and Surgeons (2002-present) ▪ American Association of Gynecologic Laparoscopists (2005-present) ▪ Society of Obstetricians and Gynecologists of Canada (2002-present) ▪ Saskatchewan Association of Gynecologic Endoscopists (2003-present) ▪ Canadian Medical Association (2002-present) ▪ Canadian Medical Protective Agency (2002-present) 5 Huse Kamencic, M.D. ▪ Saskatchewan Medical Association (2002-present) Re: AWARDS, PUBLICATIONS and PRESENTATIONS during residency AWARDS: 1. FIRST PLACE: Jerome J. Hoffman Award, Postgraduate Prize Paper on Minimally Invasive Gynecology; Presented at the Global Congress of Minimally Invasive Gynecology at the AAGL 35th Annual Meeting, November 06, 2006, Las Vegas Nevada, Title: Pentoxifylline (Trental) after Conservative Surgery for Endometriosis – A Randomized Controlled Trial. 2. SECOND PLACE: Best Gynecology Poster Junior Member – Runner –Up, presented at the SOGC 59th Annual Clinical Meeting, June 25-30, Charlottetown, PEI, Kamencic H, Brydon L. Title: Differential diagnosis of cystic adnexal masses in peri- and postmenopausal women. Volume 25, June 2003, Supplement to JOGC. 3. FIRST PLACE: Best Research Proposal for Resident Research Day, February 2004, Title: Title: Pentoxifylline (Trental) after Conservative Surgery for Endometriosis – A Randomized Controlled Trial. 4 The Brain Star Award for November 1st, 2001 by the Canadian Institute of Neurosciences, Mental Health and Addiction . Web page: http://www.cihr.ca/institutes/inmha/whatsnew/brainstar_e.shtml) PUBLICATIONS: - Mohthashami F, Kamencic H, 2012 "Enigmatic Pregnancy" accepted for publication in the Journal of Obstetrics and Gynecology Canada (in press). 1. Thiel JA, Lukwinski A, Kamencic H, Lim H. Oral analgesia vs intravenous conscious sedation during Essure Micro-Insert sterilization procedure: randomized, double-blind, controlled trial. J Minim Invasive Gynecol. 2011 JanFeb;18(1):108-11. 6 Huse Kamencic, M.D. 2. Thiel JA, Kamencic H. Assessment of costs associated with outpatient total laparoscopic hysterectom. J Obstet Gynaecol Can. 2006 Sep;28(9):794-8. 3. Thiel JA, Kamencic H. Pentoxifylline (Trental) after Conservative Surgery for Endometriosis – A Randomized Controlled Trial. J. Minim Inv Gynecol 2008 Jan-Feb, 15(1) 6266. [3] Kamencic H, Griebel RW, Lyon AW, Paterson PG, BHJ Juurlink (2001), Promoting glutathione synthesis following spinal cord trauma decreases secondary damage and promotes retention of function. FASEB J 15:243-250. [4] Kamencic H, Lyon AW, Paterson PG, BHJ Juurlink (2000), Monochlorobimane fluorometric method to measure tissue glutathione. Anal Biochem 286, 35-37. [5] Kotrusiak A.E, Paterson P.G, Kamencic H, Shoker A, Lyon A.W. Pre-column derivatization high-performance loquid chromatography method for determination of cysteine, cystinylglycine, homocystine and glutathione in plasma and cells extracts. J Chromatogr B Biomed Sci Appl. 2001 758(2):207-12. [6] Haberkorn U, Bellemann ME, Brix G, Kamencic H, Morr I, Traut U, Altmann A, Doll J, Blatter J, Kinscherf R. Apoptosis and changes in glucose metabolosm after treatment of Morris hepatoma with Gemcitabine. Europ J Nucl Med 2001 28(4):418-25. [7] Paterson PG, Juurlink BHJ, Lyon AW, Kamencic H, Andersen LB. Sulfur amino acid deficiency depresses brain glutathione concentration. Nutr Neurosci 2001 4:213-222. [8] Haberkorn U, Altmann A, Kamencic H, Morr I, Traut U, Henze M, Metz J, Kinscherf R. Glucose transport and apoptosis after gene therapy with HSV thymidine kinase. Europ J Nucl Med (in press). [9] Kinscherf R, Wagner M, Kamencic H, Bonaterra GA, Hou D, Schiele RA, Deigner HP, Metz J (1999), Characterization of apoptotic macrophages in atheromatous tissue of human and heritable hyperlipidemic rabbits. Atherosclerosis 144: 33-9. [10] Kinscherf R, Claus R, Wagner M, Gehrke C, Kamencic H, Hou D, Chen M, Nauen O, Schmiedt W, Kovacs G, Pill J, Metz J, Deigner HP (1998), Apoptosis caysed by Oxidized-LDL is manganese superoxide dismutase and p53-dependent. FASEB J 12: 461468. [11] Schmiedt W, Kinscherf R, Deigner HP, Kamencic H, Nauen O, Kilo J, Oelert H, Metz J, Bhakdi S (1998), Complement C6-deficiency protects against diet-induced atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol 18: 1790-5. 7 Huse Kamencic, M.D. [12] Kinscherf R, Deigner HP, Usinger C, Pill J, Wagner M, Kamencic H, Dongming H, Chen M, Schmiedt W, Schrader M, Kovacs G. Kato K, Metz J (1997), Induction of manganese superoxide dismutase by oxidized-LDL - its relevance in Atherosclerosis of humans and heritable hyperlipidemic rabbits. FASEB J 11: 1317-1328. [13] Kinscherf R, Kamencic H, Deigner HP, Pill J, Schmiedt W, Schrader M, Metz J (1997), Effect of alterations of blood cholesterol levels on macrophages in the myocardium of the New Zealand White rabbits. J Leukocyte Biol 62: 719-725. [14] Hehrlein C, Kollum M, Arab A, Kamencic H, Metz J (1999), Increased apoptotic cell death in the neointima after stent-based vascular irradiation: Role of radiation-induced apoptosis for restenosis reduction. J Intervent Cardiol 12(4):299-304. [15] Schultke E, Kamencic H, Zhao M, Tian GF, Baker AJ, Griebel RW, Juurlink BH. Neuroprotection following fluid percussion brain trauma: a pilot study using quercetin. J Neurotrauma. 2005 Dec;22(12):1475-84. [16] Schultke E, Kendall E, Kamencic H, Ghong Z, Griebel RW, Juurlink BH. Quercetin promotes functional recovery following acute spinal cord injury. J Neurotrauma. 2003 Jun;20(6):583-91. [17] Kinscherf R, Kamencic H, Deigner HP, Metz J. Hypercholesterolemia-induced longterm increase of macrophages in the myocardium of New Zealand White rabbits. Cells Tissues Organs. 2003;174(4):184-93. [18] Zhang W, Chen Z, Li F, Kamencic H, Juurlink B, Gordon JR, Xiang J. Tumour necrosis factor-alpha (TNF-alpha) transgene-expressing dendritic cells (DCs) undergo augmented cellular maturation and induce more robust T-cell activation and anti-tumour immunity than DCs generated in recombinant TNF-alpha. Immunology. 2003 Feb;108(2):177-88. [19] Mohamed AA, Avila JG, Schultke E, Kamencic H, Skihar V, Obayan A, Juurlink BH. Amelioration of experimental allergic encephalitis (EAE) through phase 2 enzyme induction. Biomed Sci Instrum. 2002;38:9-13. Abstracts and Poster Presentations (* Indicates poster award winner) 8 Huse Kamencic, M.D. First Poster Prize* in Postdoctoral Fellow competition the 7th Student Research Day, University of Saskatchewan, Saskatoon, January 21, 2000. [1] *Kamencic H, Matshes EW, Lyon AW, Paterson PG, Griebel RW, and BHJ Juurlink, (2000) Oxidative stress following spinal trauma can be ameliorated by procysteine compounds. The 7th Annual Life Science Research Day, 2000, p.46. [2] Gehrke C, Kinscherf R, Wagner M, Kamencic H, Schmiedt W, Pill J, Metz J, Deigner HP (1997), Oxidised-LDL induces manganese superoxide dismutase and p53 expression and apoptosis. International Atherosclerosis Society: XIth International Symposium on Atherosclerosis. October 5-9, Paris, France, Atherosclerosis 134: 212. Poster Award. [3] Kamencic H, Matshes EW, Kelly M, Griebel RW, Paterson PG and BHJ Juurlink, (2001) Procysteine compound decreases inflammation following spinal cord injury. 19th Annual National Neurotrauma Society Symposium. November 9-10, San Diego, CA. J Neurotrauma, 18(10) p. 1168. [4] Kelly M, Kamencic H, Schultke E, Griebel RW, and BHJ Juurlink, (2001) Comparison of procysteine and methylprednisolone following spinal cord injury. 19th Annual National Neurotrauma Society Symposium. November 9-10, San Diego, CA. J Neurotrauma, 18(10) p. 1168. [5] Schultke E, Kamencic H, Skihar VM, Noyan Ashraf MH, Griebel RW, and BHJ Juurlink, (2001). Does the flavonoid quercetin have potential for therapy in acute spinal cord injury? 19th Annual National Neurotrauma Society Symposium. November 9-10, San Diego, CA. J Neurotrauma, 18(10) p. 1167. [6] McKnight R, Kamencic H, and BHJ Juurlink, (2001). The therapeutic potential of OTC and sulforaphane after spinal cord injury. 19th Annual National Neurotrauma Society Symposium. November 9-10, San Diego, CA. J Neurotrauma, 18(10) p. 1135. [7] Noyan Ashraf MH, Schultke E, Kamencic H, Facci M, and BHJ Juurlink, (2001). Time dependant up-regulation of NADPH-D activity in the brain following spinal cord injury. 19th Annual National Neurotrauma Society Symposium. November 9-10, San Diego, CA. J Neurotrauma, 18(10) p. 1148. [8] Kamencic H, Lyon AW, Griebel, RW Matshes, EW, Kelly M, Paterson PG, BHJ Juurlink (2000), The pro-cysteine compound L-2-oxothiazolidine-4-carboxylate promotes retention of function following spinal cord trauma. Restorative Neurology and Neuroscience 16 (3,4) p287. [9] Kamencic H, Griebel RW, Lyon AW, Paterson PG, Kelly M, Matsches EW, BHJ Juurlink 9 Huse Kamencic, M.D. (2000), Oxidative stress following spinal cord trauma can be ameliorated by pro-cysteine compounds. First Oxidative Stress Consortium, Hamilton, ON. [10] Kamencic H, A.W. Lyon, P.G. Paterson, R.W. Griebel and B.H.J. Juurlink (1999), There is rapid onset of oxidative stress following compression-induced spinal cord injury, Soc. Neurosci. Abstr., 25, 1329. [11] Kamencic H, Lyon AW, Griebel RW, Paterson PG, and BHJ Juurlink (1999), Spinal cord injury results in rapid onset of oxidative stress, The 45th Annual Conference of the American Paraplegia Society, p.76. [12] Kamencic H, Lyon AW, Paterson PG, Griebel RW, BHJ Juurlink (1999), Oxidative stress following spinal trauma can be ameliorated by procysteine compounds, J Neurotrauma, 1999 16(10) p.975 [13] Kamencic H, A.W. Lyon, P.G. Paterson, R.W. Griebel and B.H.J. Juurlink (1999), Traumatic spinal cord injury results in rapid onset of oxidative stress, 6th Annual Life Sciences Research Day, Saskatoon, p.51 [14] Kamencic H, Lyon AW, Juurlink BHJ (1998), Comparison of two methods to determine reduced-glutathione (GSH) content in rat liver. Fifth Internet World Congress; http://www.mcmasterca/inabis98/oxidative/kamencic0562/index.html [15] Kamencic H, Kinscherf R, Deigner HP, Hou D, Bonaterra GA, Metz J (1998), Hypercholesterinämie führt zu einer langhaltenden Erhöhung von aktivierten Makrophagen im Myocard von Kaninchen. Perfusion, Jahrgang 11, Heft 2:112 (in German). [16] Kinscherf R, Deigner HP, Wagner M, Claus R, Kamencic H, Gehrke C, Hou D, Metz J (1998), Über die Pathophysiologie des oxidativen Stresses in Makrophagen in der arteriosclerotischen Gefässwand. In H. Heinle, H. Schulte, G Siegel (Hrsg) (in German). [17] Kinscherf R, Deigner HP, Kamencic H, Hou D, Metz J (1997), Early consequences of oxidative stress on macrophages in atherosclerotic plaques. 6th International Symposium “Lipoprotein metabolism: From genetics to clinical practice”. Invited presentations: [1] "Basic to Advanced, How to Move Ahead in Endoscopic Surgery" 19th West/Central CME, March 26-28, 2009, Banff, Alberta 10 Huse Kamencic, M.D. [2] “Spinal cord injury results in rapid onset of oxidative stress”, The 45th Annual Conference of the American Paraplegia Society, 7-9th September, 1999. Las Vegas, Nevada. [3] “Procysteine compouns (OTC) promotes recovery following experimental spinal cord injury”. 09/2000 University of Heidelberg, Heidelberg, Germany. [4] “Oxidative stress following spinal cord injury”. 1999 College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada. Research Project Ongoing or Completed During the Last 5 Years: “Pentoxifylline (Trental) after conservative surgery for endometriosis – A randomized control trial” Investigators: Drs. J. Thiel and H. Kamencic “Cost effectiveness of outpatient total laparoscopic hysterectomy” Investigators: Drs. J. Thiel and H. Kamencic “Outpatient total laparoscopic hysterectomy for large uteri” Investigators: Drs. J. Thiel, H. Kamencic and A. Gamelin “Relationship between ovarian cyst and early stages of ovarian cancer in postmenopausal women in Southern Saskatchewan” Investigators: Drs. L. Brydon and Huse Kamencic “Reduction of damage following neurotrauma by maintaining CNS glutathione” (We are examining the effects of procysteine compound OTC in experimental spinal cord injury model after short-term administration of the drug) Principal Investigator: Dr. Bernhard Juurlin. Agency: Neurotrauma Initiative Saskatchewan, currently Christopher reeve Paralysis Foundation “Different techniques for measurement of tissue glutathione” ( In this project I compared different methods for GSH determination (we used HPLC technique as well as a new developed method in our laboratory; monochlorobimane method). Principal investigator: Dr. Bernhard Juurlink Agency: Neurotrauma Initiative Saskatchewan “Can oral or local administration of OTC or Quercetin prevent peridural scarring after spinal surgery” (Here we would like to examine the effect of two compounds (OTC and quercetin) and their effects on the process of scarring following laminectomy in the rat) Principal Investigator: Dr. Yong Hing 11 Huse Kamencic, M.D. Agency: Clinical Research Funds of the College of Medicine, University of Saskatchewan “IL-2 and S-100 levels in serum and urine of patients after head trauma: Correlation to Glasgow Coma Score and possible outcome prediction” Agency: Clinical Research Funds of the College of Medicine, University of Saskatchewan “Dietary protein as a determinant of brain glutathione in stroke” (In this project we examine the effect of maintenance of tissue glutathione in experimental brain ischemia). Principal Investigator: Dr. P. Paterson Agency: Heart and Stroke Foundation of Saskatchewan