1 Depending on the nature of substance interaction with electromagnetic radiation optical methods of the analysis divide on: A. chromatographic B. kinetic C. emission and absorption D. conductometric E. voltammetric ANSWER: C 2 A. B. C. D. E. Decrease of intensity of light which has passed through a solution is connected: With absorption, dispersion, light reflexion Only with light absorption by investigated substance Only with light dispersion Only with light reflexion Intensity of light does not vary ANSWER: A 3 Transmission factor it is: A. Optical density of solution B. The relation of intensity of falling light to intensity of light which has passed through a solution C. The relation of intensity of light which has passed through a solution to intensity of falling light D. The relation of intensity of absorbed light to intensity of falling light E. The relation of intensity of reflected light to intensity of absorbed light ANSWER: C 4 With what decrease of intensity of light which has passed through a solution is connected: A. With absorption, dispersion, light reflexion B. Only with light absorption by investigated substance C. Only with light dispersion D. Only with light reflexion E. Intensity of light does not vary ANSWER: A 5 Absorption optical methods of the analysis are used for the analysis of some pharmaceutical preparations. What law use in absorption optical methods of the analysis? A. Laws of polarised light passage through a optical active substance solution. B. The law of light dispersion by environment. C. Characteristic law for carbon asymmetric atoms. D. Bouguer-Lambert-Beer law. E. Law of light refraction. ANSWER: D 6 The maintenance of some substance define by spectrophotometric method, knowing optical density of an investigated solution of substance and a standard solution of defined substance and concentration of a standard solution. For calculation of the quantitative maintenance it is necessary to use: A. Method of additives B. Method of calibration chart C. Comparison method D. Method of molar and specific absorptivity E. Method of limiting solutions ANSWER: C 7 The maintenance of some substance defines by spectrophotometric method, knowing the equation of linear dependence of optical density from concentration. For calculation of the quantitative maintenance it is necessary to use: A. Method of additives B. Method of calibration chart C. Comparison method D. Method of molar and specific absorptivity E. Method of limiting solutions ANSWER: B 8 A. B. C. D. E. To obtaining of monochromatic radiation apply: Optical filters; Photocells; Diffraction grating; System of lenses; Light source. ANSWER: C 9 Optical density of an investigated solution measure in relation to one solution which is called: A. The control B. The compensatory C. The blank D. The second investigated E. Control or blank ANSWER: B 10 The size of refraction index in refractometric method of the analysis depends: A. With all factors B. The substance nature C. Solution density D. Lengths of falling light E. Temperatures and pressure ANSWER: A 11 In a basis of refractometric measurements of solutions bases the dependence between concentration of substance solution and its refraction index, expressed by the formula: n = n0 + F • C, where F is: A. The factor equal to the relation of refraction index of solution to refraction index of solvent B. The factor equal to a gain of an index at increase of concentration on 0,10 % C. The factor equal to a gain of an refraction index at increase of concentration on 1 % D. The factor equal to an refraction index of a solution under normal conditions E. The factor equal to a rotation angle of a light plane ANSWER: C 12 The refractometric method is used in drugstores for: A. Qualitative definition of cations B. Quantitative definition of medicinal substances C. Qualitative definition of anions D. Definitions of impurity in substances E. Definition of very small concentration of substances ANSWER: B 13 In refractometric method of the analysis the size of refraction index depends from: A. Lengths of falling light B. The substance nature C. Solution density D. From all factors E. Temperatures and pressure ANSWER: D 14 The angle of rotation, wich is defined at temperature 20 C and wave length of a D-line of sodium spectrum (= 589.3 nanometers), name: A. Angle of light falling B. Refraction index C. Angle of rotation of a polarisation plane D. Specific angle of rotation E. Angle of light refraction ANSWER: D 15 The substances, capable to rotate a polarisation plane of light ray, name optical active substances. Optical activity of substance can be connected with: A. Electrolitic dissosiation of investigated substance B. In temperature a solution C. Concentration of substance D. Solvent in which the investigated substance is dissolved E. Features of crystal lattice of substances, features of molecules structure ANSWER: E 16 The polarisation plane is: A. The plane is perpendicular to a fluctuation plane of the polarised light ray B. The plane of fluctuation of the polarised light ray C. Planes which are perpendicular to a direction of distribution of light D. Parallel to fluctuation plane of the polarised light ray E. Planes which are parallel to a direction of distribution of light ANSWER: A 17 Polarimetric method of the analysis is one of instrumental methods of the analysis, used for the analysis of some pharmaceutical preparations. Definition of substances by this method is based on... A. Measurement of polarisation of electrodes in a cell filled by investigated solution B. Potential difference measurement between electrodes poles in the course of titration C. Power failure measurement in a cell filled by investigated solution D. Ionic exchange between an analyzed solution and cationite E. Measurement of a angle rotation of polarisation plane of the polarised light which has passed through the optical active environment ANSWER: E 18 What substances can be defined by two methods: polarimerty and refractometry? A. Ascorbic acid B. Sodium benzoate C. Potassium bromide D. Sodium thiosulfate E. Magnesium sulphate ANSWER: A 19 At definition of the substances maintenance by polarimetric method define: A. Molar concentration B. Titre C. Volume concentration D. Mass-volume fraction in solution E. Mass fraction in solution ANSWER: D 20 Physical methods of the medicinal substances analysis it... A. polarimetric and refractometric B. nitritometry and mercurometry C. chelatometry, complexymetry D. argentometry, mercurometry E. fluoridometry, acidimetric ANSWER: A 21 The calcium chloride quantity in 5 % calcium chloride solution defines by physical method... A. alcalimetry B. refractometry C. nitritometry D. cerimetry E. polarimetry ANSWER: B 22 The refractometric method in the drugstore conditions can be applied to the quantitative analysis: A. Chemist's preparations, powders, liquid medicinal forms with the maintenance of components not below 3-5 % B. Liquid medicinal forms with the maintenance of components not above 1 % C. Firm medicinal forms with the maintenance not above 0,1 % D. Liquid medicinal forms with the maintenance not above 1 % E. Exclusively soft medicinal forms ANSWER: A 23 The magnesium sulphate maintenance in the medicinal form: the 25 % magnesium sulphate solution can be defined by physical method... A. refractometry B. acidimetry C. bromatometry D. titanometry E. polarimetry ANSWER: A 24 The sodium bromide maintenance in the medicinal form: the 20 % sodium bromide solution can be defined by physical method... A. chelatometry B. refractometry, argentometry C. nitritometry D. bromatometry E. permanganatometry ANSWER: B 25 The calcium chloride maintenance in the medicinal form: the 5 % calcium chloride solution can be defined by physical method... A. refractometry B. iodometry C. nitritometry D. electrogravimetry E. polarimetry ANSWER: A 26 The physical method of glucose quantitative definition in the medicinal form: a 25 %glucose solution is... A. refractometry B. chelatometry C. nitritometry D. electrogravimetry E. iodometry ANSWER: A 27 The aminocaproic acid quantitative definition in 5 % solution spends by refractometric method, using settlement reception of the quantitative analysis. In it n0 it is a refraction index of... A. Ethanol B. Water C. Any liquid D. Any organic solvent E. Aminocaproic acid ANSWER: B 28 The aminocaproic acid quantitative definition in 5 % solution spends by refractometric method, using settlement reception of the quantitative analysis. In it n it is a refraction index of... A. Ethanol B. Water C. Any liquid D. Any organic solvent E. Investigated aminocaproic acid solution ANSWER: E 29 What physical method is based on measurement of optical properties of investigated system? A. IR-spectroscopy B. Coulometry C. Iono-exchange chromatography D. The mass spectrometer analysis E. Activation the analysis ANSWER: A 30 In infra-red spectroscopy active molecules: A. In the vibration process which changes the electric dipole moment B. Nonpolar molecules C. Molecules with odd mass number D. Molecules with even mass number E. Molecules with heavy nucleus ANSWER: A 31 In infra-red spectroscopy substance molecules are inactive: A. Methylamine B. Water C. Oxygen D. Dimethylamine E. Phenylamine ANSWER: C 32 In infra-red spectroscopy substance molecules are inactive: A. CH3NH2; B. H2O; C. N2; D. (CH3)2NH; E. C6H5NH2. ANSWER: C 33 What fluctuations are not shown in an infra-red spectrum? A. The deformation B. The symmetric stretching C. The asymmetric stretching D. The rocking E. The nuclear ANSWER: E 34 The region of "prints of fingers" is applied in infra-red spectroscopy to identification of substances as in this region the absorption connected with fluctuation is shown: A. Hydroxy-groups B. Amino groups C. Skeleton of the molecule D. All functional groups E. Benzene rings ANSWER: C 35 The absorption band in the infrared spectrum is characterized by: A. Frequency of vibration, intensity of absorption B. Wavelength of a maximum, intensity of absorption C. Energy of vibration, intensity of a luminescence D. Wavelength of a minimum of absorption, in optical density E. The frequency of fluctuation turned by fluctuation frequency ANSWER: A 36 The qualitative analysis in IR-spectroscopy carry out: A. Wavelength of a maximum of a separate band B. Comparison of investigated substance spectrum and standard sample of the same substance spectrum C. Wavelength of minimum transmission of separate band D. Over a range of wavelengths of the shoulder in the spectrum of test solution E. On wave numbers of absorption bands in a region of 4000-1500 sm-1 ANSWER: B 37 Quantitative analysis within IR spectroscopy carried out on the parameter of the absorption band: A. Specific density in maximum band B. Optical density in minimum band C. Wavelength of maximum band D. Wave number of maximum band E. Intensity of absorption in maximum band ANSWER: E 38 Theoretical base of the quantitative analysis in IR-spectroscopy is the law: A. Lomonosov B. Mendeleyev C. Ohms D. Nernst E. Bouguer-Beer-Lambert law ANSWER: E 39 What techniques of quantitative analysis used in infrared spectroscopy? A. Method performance (estimated) B. Calibration chart C. Comparison method D. Method of comparison and performence method E. Additive method ANSWER: B 40 Identification of substances by the spectra in the UV and visible spectral region based on a comparison of the wavelengths of the maxima, and inflection points of intersection. In addition, further definition is sometimes necessary ... at these wavelengths. A. Refraction indexes B. Refraction factor C. Specific rotation D. Specific absorption index E. Angle of rotation of a polarisation plane ANSWER: D 41 When passing through a layer of optically active material undergoes optical rotation only: A. UV – light B. IR – radiation C. Polarised light D. Radiation of a visible region of spectrum E. Radioactive radiation ANSWER: C 42 Specific rotation name rotation of a plane of polarisation in the right or left side which occurs at passage of polarised light through a layer of a solution in the thickness ... with concentration 1g/sm3 A. 1 sm B. 2 dm C. 1 dm D. 10 mm E. 2 sm ANSWER: C 43 Specific rotation name rotation of a plane of polarisation in the right or left side which occurs at passage of polarised light through a layer of a solution in the thickness of 1 dm to concentration..... A. 1 g/sm3 B. 10 g/sm3 C. 10 g/dm3 D. 10g/ml. E. 1 g/dm3 ANSWER: A 44 Measurement of the angle of rotation passes through the layer of the optically active substance solution is carried out using an instrument: A. Refractometer B. Potentiometer C. Polarograph D. Polarimeter E. Coulometer ANSWER: D 45 Specific rotation is a constant which apply for: A. The analysis B. Identification C. The quantitative analysis D. Definition of cleanliness from impurity which can be optical active E. In all listed cases ANSWER: E 46 Specific rotation of glucose +53,1, therefore glucose solution with concentration of 0,1 g/ml, placed in polarimetric tube in the thickness of 1 dm, will have a rotation angle: A. +5,3 B. -5,3 C. +10,6 D. -10,6 E. +53,1 ANSWER: A 47 Specific rotation of sucrose +66,4, therefore sucrose solution with concentration of 0,2 g/ml, placed in polarimetric tube in the thickness of 1 dm, will have a rotation angle: A. +6,64 B. -6,64 C. +13,28 D. -13,28 E. +33,2 ANSWER: C 48 Specific rotation of fructose -93,0, therefore fructose solution with concentration of 0,2 g/ml, placed in polarimetric tube in the thickness of 1 dm, will have a rotation angle: A. -9,3 B. -18,6 C. +18,6 D. -46,5 E. +9,3 ANSWER: B 49 Specific rotation of fructose -93,0, therefore fructose solution of with concentration of 0,1 g/ml, placed in polarimetric tube in the thickness of 1 dm, will have a rotation angle: A. -9,3 B. -18,6 C. +18,6 D. -46,5 E. +9,3 ANSWER: A 50 Specific rotation of ascorbic acid +23,0, therefore solution with 10,0 г ascorbic acid in 100 ml of the solution, placed in polarimetric tube in the thickness of 1 dm, will have a rotation angle: A. -23,0 B. +23,0 C. +230 D. -230 E. +2,3 ANSWER: E 51 Specific rotation of lactose +53,5. Have prepared a solution containing 10 г of lactose in 100 ml of solution, and have measured a rotation angle at a thickness of a layer of 1 dm. The angle of rotation of the given solution should be: A. -5,3 B. +5,35 C. -5,35 D. -10,7 E. +10,7 ANSWER: B 52 For what substance at tests for cleanliness there can be a test – definition of specific rotation? A. Glycine B. Glycerol C. Glucose waterless D. Sodium phosphate E. Glycerol trinitrate solution ANSWER: C 53 For what substance in tests for cleanliness there can be a definition of specific rotation? A. Glycine B. Glycerol C. Alanine D. Vanillin E. Boric acid ANSWER: C 54 For what substance in tests for cleanliness there can be a definition of specific rotation? A. Vanillin B. Glycine C. Glycerol D. Glutamic acid E. Boric acid ANSWER: D 55 What identification of substance can be spent on specific rotation? A. Vanillin B. Glycine C. Glycerol D. Glutamic acid E. Boric acid ANSWER: D 56 What identification of substance can be spent on specific rotation? A. Boric acid B. Glycine C. Ascorbic acid D. Vanillin E. Glycerol ANSWER: C 57 What identification of substance cannot be spent on specific rotation? A. Valine B. Glycine C. Glutamic acid D. Ascorbic acid E. Isoleucine ANSWER: B 58 Refractometry is based on measurement: A. Absolute index of refraction B. Relative index of refraction C. Optical density D. Transmission factor E. Specific rotation ANSWER: B 59 In refractometry measure: A. N B. n 20D C. 20D D. A E. T ANSWER: B 60 The relative index of refraction is the relation: A. B. C. D. E. n=Cair/C H O N=Cvacuum/Сmedium n=Cair/Сmedium A=-lgT T=10-A 2 ANSWER: C 61 The absolute index of refraction is the relation: A. B. C. D. E. N=Cvacuum/C H O N=Cvacuum/Сmedium n=Cair/Сmedium n = Ссреды/Cair N=Cvacuum/Сair 2 ANSWER: B 62 Absolute and relative index of refraction are connected by the relation: A. A=-lgT B. T=10-A C. n=1.00027N D. N=1.00027n E. 20 D *1000 C *l ANSWER: D 63 Construction of calibration curve for refractometric determination is carried out in the coordinates: A. T = f (C) B. A = f (C) C. N = f (C) D. E = f (C) E. n = f (C) ANSWER: E 64 When the calculated method of the substance concentration determining by refractometric method used the formula C== A. B. C. D. E. n n0 . Designation of "F": F Stoichiometric factor Faraday's constant Gravimetric factor Refractometric factor Refractometric an absorption index ANSWER: D 65 Correct record of the formula for refractometric concentration definitions in method with application of the refractometric factor: n n0 A. С % = F n0 n B. C % = C. C % = F nF n n0 F D. C = n n0 n E. СN = F ANSWER: A 66 The refractometric factor determine, having made two standard solutions and having measured their indexes of refraction, under the formula: A. F = С1 С2 n1 n2 n2 n1 B. F = C2 C1 n2 n1 C. F = C1 C2 n1 n2 D. F = C2 C1 n2 n2 n1 C E. F = ANSWER: B 67 Lack of refractometry is: A. Simplicity of the applied device B. Speed of performance of the analysis C. Low sensitivity and nonselectivity D. Simplicity of service and analysis performance E. Definition possibility in one-, two- and three-componental systems after association with the chemical analysis ANSWER: C 68 The analysis of a two-componental mix is not possible in a case, when: A. Spectra of both substances are not blocked B. Spectra of both substances are blocked, but is absorption maxima are divided C. Spectra of both substances are blocked, but there is a spectrum site where absorbs only one substance D. Spectra of both substances are blocked also absorption maxima completely imposed E. Absorbs only one substance, and the second in an investigated range is transparent ANSWER: D 69 To reduce systematic errors in photometric measurements to be collected solution concentration and the thickness of the layer so that the measured optical densities were in the range: A. 0,4-0,6 B. 0,02-0,06 C. 2-6 D. 0,6-0,8 E. 0,2-0,3 ANSWER: A 70 Validation of analytical methods - is experimental evidence that the technique .....: A. Very good and easy B. Suited for the task C. It is characterised by necessary metrological characteristics D. Theoretically scientifically proved E. Practical and rational ANSWER: B 71 Validation an analytical technique or process is: A. Theoretical justification of methods or processes B. C. D. E. Verification methodology or process logically The experimental proof of their suitability Scientifically based evidence of their ability to provide acceptable quality Feasibility study of their suitability ANSWER: C 72 Validation characteristic “accuracy” is typical for tests: A. Only quantitative definition B. Quantitative definition and quantitative test for the maintenance of impurity C. Identifications D. Identification and quantitative definition E. Identifications and tests for the limiting maintenance of impurity ANSWER: B 73 Validation characteristic “accuracy” means that received results are: A. Are close to true value B. Are close to average arithmetic value C. Are close to true or average arithmetic value D. Highly selective and very specific E. Are close among themselves - not so differ ANSWER: C 74 Studying of “accuracy” of an analytical technique spend a method: A. It is entered – it is found B. The least square method C. Fisher D. Student's method E. Dispersion and an excess ANSWER: A 75 Method it is entered-is found, with use of standard samples of components defined by a given technique, it is applied to studying validation characteristic: A. Accuracy B. Convergence C. Linearity D. Application range E. Accuracy and precision ANSWER: E 76 The validation characteristic "accuracy" specifies that received results are: A. Are close to true value B. Are close to average arithmetic value C. Close to true or average arithmetic value D. Highly selective and very specific E. Close to each other are slightly different ANSWER: E 77 Accuracy and precision are metrological characteristics which are investigated at test validation: A. Identifications by chemical methods B. Identifications by physical and physical and chemical methods C. Quantitative definition of an active pharmaceutical component and impurity D. Limiting tests for the maintenance of impurity E. Definitions quantitative only biological methods ANSWER: C 78 As result of testing of a technique on validation characteristic “linearity” , provide data: A. The equation of a straight line with all its factors B. Factors of the equation of a straight line and correlation factor C. Correlation factor D. Tangent of a angle of an inclination of a straight line and all standard deviations for equation factors E. All listed ANSWER: E 79 Full uncertainty of the analysis is designated by a symbol: A. B. C. D. E. As SP FAO ANSWER: A 80 Predicted uncertainty of sample preparation is designated by a symbol: A. B. C. D. E. As SP FAO ANSWER: B 81 Uncertainty of final analytical operation is designated by a symbol: A. B. C. D. E. As SP FAO ANSWER: C 82 At the uncertainty forecast of sample preparation which spend for spectrophotometric definition, consider uncertainty of everything, except: A. Chemical utensils B. Pipettes C. Weight D. Spectrophotometer E. Measured flask ANSWER: D 83 Full uncertainty of the analysis of a substance of medicinal substance in percentage pays off under the formula: BH BL 0,32 2 A. B BL As H 0,12 2 B. C. As BH 100% D. SP 0,32 As E. SP 0,32 As ANSWER: C As 84 To designation there corresponds SP the name: A. Predicted uncertainty of the analysis B. Predicted uncertainty of simple preparation C. Predicted uncertainty of final analytical operation D. Predicted uncertainty of the analysis of a ready medical product E. Predicted uncertainty of the analysis of a substance of medicinal substance ANSWER: B 85 To designation there corresponds As the name: A. Predicted uncertainty of the analysis B. Predicted uncertainty of simple preparation C. Predicted uncertainty of final analytical operation D. Predicted uncertainty of the analysis of a ready medical product E. Predicted uncertainty of the analysis of a substance of medicinal substance ANSWER: A 86 To designation there corresponds FAO the name: A. Predicted uncertainty of the analysis B. Predicted uncertainty of sample preparation C. Predicted uncertainty of final analytical operation D. Predicted uncertainty of the analysis of a ready medical product E. Predicted uncertainty of the analysis of a substance of medicinal substance ANSWER: C 87 The normalized coordinates of concentration and the analytical response (physical size) at validation the techniques of the analysis which are carried out by various methods are represented in units: A. Percent B. mg/ml C. mmol/l D. mol/l E. g/ml ANSWER: A 88 The normalized coordinates of concentration and the analytical response (physical size) at validation the techniques of the analysis which are carried out by various methods have arisen because it was necessary: A. To unify a way of expression of concentration B. C. D. E. To unify a way of measurement (direct or relative) To unify a sort of measured physical sizes To unify the size of measured physical sizes To unify criteria requirements for all methods ANSWER: E 89 To designation there corresponds X i the name: A. The normalized coordinate of the measured physical size B. The normalized coordinate of concentration C. Unknown size D. Argument of function of linear dependence E. Argument of function which is direct proportionality ANSWER: B 90 To designation there corresponds Yi the name: A. The normalized coordinate of the measured physical size B. The concentration coordinate is normalized C. The size is unknown D. Argument of function of linear dependence E. Argument of function which is direct proportionality ANSWER: A 91 The normalized coordinates count X i under the formula in C i is A. The normalized value of the measured physical size B. Concentration is normalized C. The unknown (not measured) size D. Concentration of substance in one of analyzed solutions E. Argument of function which is direct proportionality Xi Ci 100% C st which ANSWER: D 92 The normalized coordinates count Yi under the formula in Yi Ai 100% which Ai Ast is A. The normalized value of the measured physical size B. The normalized concentration C. Analytical signal of substance in one of solutions D. Concentration of one of the solutions, expressed in terms of concentration E. Argument of function which is direct proportionality ANSWER: C 93 At studying of the metrological characteristic "linearity", count the equation of calibration chart which will look like: A. B. C. D. Yi b X i3 a Yi b X i a Yi b X i2 a Yi b X i a E. Yi b X 2 a i ANSWER: B 94 At studying of the metrological characteristic "linearity", count the correlation factor which value should be: A. From-2 to +2 B. From -1 to +1 C. From -3 to +3 D. Less than 1 E. More than 2 ANSWER: B 95 By working out of techniques it is recommended to choose so shot weight and measured flask that uncertainty of simple preparation was insignificant - that the requirement was fulfilled: A. B. C. D. E. SP 0,32 As SP 0,32 As SP 0,32 As SP 0,32 As SP 0,32 As ANSWER: A 96 The technique will be correct if in it the requirement is put in pawn, about predicted uncertainty of simple preparation which satisfies to a condition: A. B. C. D. E. SP 0,32 As SP 0,32 As SP 0,32 As SP 0,32 As SP 0,32 As ANSWER: B 97 Full uncertainty of the analysis of a ready medical product in percentage pays off under the formula: BH BL 0,32 2 A. B BL As H 0,12 2 B. C. As BH 100% D. SP 0,32 As E. SP 0,32 As ANSWER: A As 98 Full uncertainty of the analysis is designated by a symbol: A. B. C. D. E. As SP FAO ANSWER: A 99 Predicted uncertainty of sample preparation is designated by a symbol: A. B. C. D. E. As SP FAO ANSWER: B 100 Uncertainty of final analytical operation is designated by a symbol: A. B. C. D. E. As SP FAO ANSWER: C