Database: Ovid MEDLINE(R) <1996 to March Week 3 2010> Search Strategy: -------------------------------------------------------------------------------1 *abortion, induced/ (3791) 2 South Africa/ (12265) 3 1 and 2 (36) 4 limit 3 to english language (36) 5 from 4 keep 1-36 (36) *************************** <1> Unique Identifier 19689791 Status MEDLINE Authors Harries J. Stinson K. Orner P. Authors Full Name Harries, Jane. Stinson, Kathryn. Orner, Phyllis. Institution Women's Health Research Unit, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa. Jane.Harries@uct.ac.za Title Health care providers' attitudes towards termination of pregnancy: a qualitative study in South Africa. Source BMC Public Health. 9:296, 2009. Other ID Source: NLM. PMC2734857 Abstract BACKGROUND: Despite changes to the abortion legislation in South Africa in 1996, barriers to women accessing abortion services still exist including provider opposition to abortions and a shortage of trained and willing abortion care providers. The dearth of abortion providers undermines the availability of safe, legal abortion, and has serious implications for women's access to abortion services and health service planning.In South Africa, little is known about the personal and professional attitudes of individuals who are currently working in abortion service provision. Exploring the factors which determine health care providers' involvement or disengagement in abortion services may facilitate improvement in the planning and provision of future services. METHODS: Qualitative research methods were used to collect data. Thirty four in-depth interviews and one focus group discussion were conducted during 2006 and 2007 with health care providers who were involved in a range of abortion provision in the Western Cape Province, South Africa. Data were analysed using a thematic analysis approach. RESULTS: Complex patterns of service delivery were prevalent throughout many of the health care facilities, and fragmented levels of service provision operated in order to accommodate health care providers' willingness to be involved in different aspects of abortion provision. Related to this was the need expressed by many providers for dedicated, stand-alone abortion clinics thereby creating a more supportive environment for both clients and providers. Almost all providers were concerned about the numerous difficulties women faced in seeking an abortion and their general quality of care. An overriding concern was poor pre and post abortion counselling including contraceptive counselling and provision. CONCLUSION: This is the first known qualitative study undertaken in South Africa exploring providers' attitudes towards abortion and adds to the body of information addressing the barriers to safe abortion services. In order to sustain a pool of abortion providers, programmes which both attract prospective abortion providers, and retain existing providers, needs to be developed and financial compensation for abortion care providers needs to be considered. Publication Type Journal Article. Research Support, Non-U.S. Gov't. <2> Unique Identifier 19418325 Status MEDLINE Authors Patel CJ. Kooverjee T. Authors Full Name Patel, Cynthia J. Kooverjee, Trisha. Institution School of Psychology, University of KwaZulu-Natal, Durban, South Africa. patelc@ukzn.ac.za Title Abortion and contraception: attitudes of South african university students. Source Health Care for Women International. 30(6):550-68, 2009 Jun. Abstract Despite the availability of contraception, the rates of abortion among young women in South Africa continue to increase. We designed a study to examine young people's attitudes about abortion and contraception. One hundred and eighty-eight South African university students (97 females and 91 males) completed the survey. While we found moral objections to abortion for the sample as a whole, females showed stronger support for availability of abortion and women's autonomy compared with males. The respondents acknowledged the importance of contraception at a personal and general level, but more than 40% of them believed that women who use contraception are promiscuous. Females expressed difficulty with usage more frequently than males and indicated that they would not consider sexual intercourse if contraception were not available. For health care workers involved in counseling young people about their sexual and reproductive choices, the challenge lies in promoting a culture of equal rights and respect for women's reproductive freedom. Publication Type Journal Article. <3> Unique Identifier 18772094 Status MEDLINE Authors Hyman AG. Baird TL. Basnett I. Authors Full Name Hyman, Alyson G. Baird, Traci L. Basnett, Indira. Institution Ipas, Chapel Hill, NC, USA. hymana@ipas.org Title Establishing second trimester abortion services: experiences in Nepal, Viet Nam and South Africa. Source Reproductive Health Matters. 16(31 Suppl):135-44, 2008 May. Abstract This paper describes experiences and lessons learned about how to establish safe second trimester abortion services in low-resource settings in the public health sector in three countries: Nepal, Viet Nam and South Africa. The key steps involved include securing the necessary approvals, selecting abortion methods, organising facilities, obtaining necessary equipment and supplies, training staff, setting up and managing services, and ensuring quality. It may take a number of months to gain the necessary approvals to introduce or expand second trimester services. Advocacy efforts are often required to raise awareness among key governmental and health system stakeholders. Providers and their teams require thorough training, including values clarification; monitoring and support following training prevents burn-out and ensures quality of care. This paper shows that good quality second trimester abortion services are achievable in even the most low-resource settings. Ultimately, improvements in second trimester abortion services will help to reduce abortion-related morbidity and mortality. Publication Type Journal Article. <4> Unique Identifier 18772091 Status MEDLINE Authors Turner KL. Hyman AG. Gabriel MC. Authors Full Name Turner, Katherine L. Hyman, Alyson G. Gabriel, Mosotho C. Institution Ipas, Chapel Hill, NC, USA. turnerk@ipas.org Title Clarifying values and transforming attitudes to improve access to second trimester abortion. Source Reproductive Health Matters. 16(31 Suppl):108-16, 2008 May. Abstract Access to safe second trimester abortion services is poor in many countries, sometimes despite liberal laws and policies. Addressing the myriad factors hindering access to safe abortion care requires a multi-pronged strategy. Workshops aimed at clarifying values are useful for addressing barriers to access stemming from misinformation, stigmatization of women and providers, and negative attitudes and obstructionist behaviours. They engage health care providers and administrators, policymakers, community members and others in a process of selfexamination with the goal of transforming abortion-related attitudes and behaviours in a direction supportive of women seeking abortion. This is especially important for women seeking second trimester abortion, which tends to be even more stigmatized than first trimester abortion. This paper reports on some promising experiences and results from workshops in Viet Nam, Nepal and South Africa. Some recommendations that emerge are that values clarification should be included in abortion training, service delivery and advocacy programmes. Evaluations of such interventions are also needed. Publication Type Journal Article. <5> Unique Identifier 18772086 Status MEDLINE Authors Alblas M. Authors Full Name Alblas, Marijke. Institution Medical Consultant, Cape Town, South Africa. malblas@iafrica.com Title A week in the life of an abortion doctor, Western Cape Province, South Africa. Source Reproductive Health Matters. 16(31 Suppl):69-73, 2008 May. Abstract South Africa legalized abortion in 1996. I am originally from the Netherlands and came to South Africa in 2000, to assist in the Termination of Pregnancy programme. In March 2007, at an international conference on second trimester abortion, I described my life as an abortion doctor living in Cape Town, South Africa. I was urged to write down what my working life in the Western Cape is like, and this paper is the result. It is a diary of a typical work week, recorded in early 2008. Publication Type Journal Article. <6> Unique Identifier 17888919 Status MEDLINE Authors van Bogaert LJ. Authors Full Name van Bogaert, L J. Institution Department of Obstetrics and Gynecology, Saint Rita's Hospital, Limpopo, South Africa. ljfvanbo@lantic.net Title Termination of pregnancy with misoprostol in the scarred uterus. Source International Journal of Gynaecology & Obstetrics. 100(1):80-1, 2008 Jan. Publication Type Journal Article. <7> Unique Identifier 18264602 Status MEDLINE Authors Bateman C. Authors Full Name Bateman, Chris. Title Maternal mortalities 90% down as legal TOPs more than triple. [Review] [0 refs] Source South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde. 97(12):1238-42, 2007 Dec. Publication Type Journal Article. Review. <8> Unique Identifier 17701803 Status MEDLINE Authors van Bogaert LJ. Sedibe TM. Authors Full Name van Bogaert, L-J. Sedibe, T M. Institution Department of Obstetrics and Gynaecology, St Rita's Hospital, Glen Cowie, South Africa. ljfvanbo@lantic.net Title Efficacy of a single misoprostol regimen in the first and second trimester termination of pregnancy. Source Journal of Obstetrics & Gynaecology. 27(5):510-2, 2007 Jul. Abstract A total of 273 women underwent termination of pregnancy (TOP) with a single regimen of misoprostol (400 microg orally and 800 microg vaginally), without mifepristone. A total of 98 (35.9%) were first trimester and 175 (64.1%) second trimester gestations. Of these women, 189 (69.2%) responded to a single administration of misoprostol and 84 (30.8%) required between two and six administrations of misoprostol. The medical TOP was complete in 90.8% of all cases. A surgical intervention was needed in 23 (27.4%) of those requiring repeated administrations of misoprostol vs only two (1.1%) of those responding to a single administration. Age, parity and gestational age did not affect the response rate to the misoprostol regimen. The need for a D&C was related to the response to misoprostol: most D&Cs were needed in cases of repeat administrations of misoprostol. This study shows the feasibility of medical TOP in the developing world. It has the great advantage of significantly reducing the need for surgical termination where the required skills are scarce. Publication Type Journal Article. <9> Unique Identifier 17439565 Status MEDLINE Authors Blanchard K. Cooper D. Dickson K. Cullingworth L. Mavimbela N. von Mollendorf C. van Bogaert LJ. Winikoff B. Authors Full Name Blanchard, K. Cooper, D. Dickson, K. Cullingworth, L. Mavimbela, N. von Mollendorf, C. van Bogaert, L J. Winikoff, B. Institution Ibis Reproductive Health, Cambridge, MA 02138, USA. kblanchard@ibisreproductivehealth.org Title A comparison of women's, providers' and ultrasound assessments of pregnancy duration among termination of pregnancy clients in South Africa. Source BJOG: An International Journal of Obstetrics & Gynaecology. 114(5):569-75, 2007 May. Abstract OBJECTIVE: To compare providers' and women's estimates of duration of pregnancy with ultrasound estimates for determining medical abortion eligibility. DESIGN: Cross-sectional study. SETTING: Public termination of pregnancy (TOP) services in three provinces. SAMPLE: A total of 673 women attending the above services for TOP. METHODS: Women participating in a medical abortion feasibility study in South Africa provided estimates of pregnancy duration and date of last menstrual period (LMP). Each woman also had clinical and ultrasound exams. We compared estimates using the four methods, calculating the proportion of women in the 'caution zone' (< or = 8 weeks gestation by woman or provider estimate and > 8 weeks by ultrasound). MAIN OUTCOME MEASURES: Mean gestational age by each method; difference between provider and LMP estimates and ultrasound estimates; and percentage of women in the 'caution zone'. RESULTS: Women's estimates of pregnancy duration were 19 days fewer than ultrasound estimates (95% CI = -27 to 63). Mean provider- and LMP-based estimates were two (95% CI = -30 to 35) and less than one day(s) (95% CI = -46 to 51) fewer than ultrasound estimates. Comparing provider and ultrasound estimates, 15% of women were in the 'caution zone'; this fell to 12% if estimates of 9 weeks or fewer were considered acceptable. CONCLUSIONS: Provider estimates of gestational age were sufficiently accurate for determining eligibility for medical abortion. LMP-based estimates were also accurate on average, but included more extreme differences from ultrasound estimates. Medical abortion could be provided in TOP facilities without ultrasound or with ultrasound on referral. Publication Type Comparative Study. Journal Article. Multicenter Study. Research Support, Non-U.S. Gov't. <10> Unique Identifier 17484194 Status MEDLINE Authors Blanchard K. Schaffer K. McLeod S. Winikoff B. Authors Full Name Blanchard, Kelly. Schaffer, Kate. McLeod, Shamiema. Winikoff, Beverly. Institution Ibis Reproductive Health, Cambridge, MA 02138, USA. kblanchard@ibisreproductivehealth.org Title Medication abortion in the private sector in South Africa. Source European Journal of Contraception & Reproductive Health Care. 11(4):285-90, 2006 Dec. Abstract OBJECTIVES: To collect information about how private physicians in South Africa provide medication abortion services to their patients. METHODS: In April 2003 we asked physicians in private practice in South Africa who had purchased mifepristone (Mifegyne) from the South African distributor about the medication abortion regimen they offered, satisfaction with the method, and how services have been incorporated into their practices. RESULTS: Forty-four providers participated in the survey. They report using a range of doses and regimens. Most respondents offer mifepristone-misoprostol to their patients, although a significant minority also offer misoprostol-alone for pregnancy termination. While the majority of medication abortion providers also offer surgical abortions, a significant number of non-surgical providers were only offering medication abortion. CONCLUSION: South African medication abortion providers find the method acceptable, indicate that their staff are largely supportive of offering it to their patients, and report that clients like the method. Those surveyed believe that most of their patients are eligible for the regimen, although uptake has been limited. Publication Type Journal Article. Research Support, Non-U.S. Gov't. <11> Unique Identifier 17167706 Status MEDLINE Authors Pattinson RC. Snyman LC. Macdonald AP. Authors Full Name Pattinson, R C. Snyman, L C. Macdonald, A P. Institution MRC Maternal and Infant Health Care Strategies Research Unit and Department of Obstetrics and Gynaecology, University of Pretoria, South Africa. Title Evaluation of a strict protocol approach in managing women with severe disease due to abortion. Source South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde. 96(11):1191-4, 2006 Nov. Abstract AIM: To evaluate whether the introduction of a strict protocol approach based on the systemic evaluation of critically ill pregnant women with complications of abortion affected outcome. SETTING: Indigent South Africans managed in the regional and tertiary hospitals of the Pretoria Academic Complex. METHOD: Since 1997 a standard definition of severe acute maternal morbidity (SAMM) has been used in the Pretoria Academic Complex. All cases of SAMM and maternal deaths were entered on the Maternal Morbidity and Mortality Audit System programme. A comparison of outcome of severely ill women who had complications of abortion was made between 1997-1998 (original protocol) and 2002-2004 (strict protocol). OUTCOME MEASURES: The mortality index and prevalence of organ system failure or dysfunction. RESULTS: In 1997-1998 there were 43 women with SAMM who survived and a further 10 maternal deaths due to complications of abortion, compared with 107 women with SAMM and 7 maternal deaths during 2002-2004. The mortality index declined from 18.9% in 1997-1998 to 6.1% in 2002-2004 (p = 0.02, odds ratio 0.28, 95% confidence limits 0.10 - 0.79). Significantly more women had hypovolaemic shock in 2002-2004 compared with 1997-1998 (54.4% v. 35.8%, p = 0.04), but fewer women had immune system failure including septic shock (18.4% v. 47.2%, p = 0.0002) and metabolic dysfunction (0 v. 5.7%, p = 0.03) and there was a trend to less renal failure (10.5% v. 22.6%, p = 0.06) and cardiac failure (4.4% v. 13.2%, p = 0.08). CONCLUSION: The strict protocol approach based on systemic evaluation in managing critically ill pregnant women with complications of abortion, coupled with an intensive, regular feedback mechanism, has been associated with a reduction in the mortality index. Publication Type Evaluation Studies. Journal Article. Multicenter Study. <12> Unique Identifier 17141703 Status MEDLINE Authors Warriner IK. Meirik O. Hoffman M. Morroni C. Harries J. My Huong NT. Vy ND. Seuc AH. Authors Full Name Warriner, I K. Meirik, O. Hoffman, M. Morroni, C. Harries, J. My Huong, N T. Vy, N D. Seuc, A H. Institution UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, WHO, Geneva 1211, Switzerland. warrineri@who.int Title Rates of complication in first-trimester manual vacuum aspiration abortion done by doctors and mid-level providers in South Africa and Vietnam: a randomised controlled equivalence trial. Comments Comment in: Lancet. 2006 Dec 2;368(9551):1939-40; PMID: 17141683] Source Lancet. 368(9551):1965-72, 2006 Dec 2. Abstract BACKGROUND: We assessed whether the safety of first-trimester manual vacuum aspiration abortion done by health-care providers who are not doctors (mid-level providers) is equivalent to that of procedures done by doctors in South Africa and Vietnam, where mid-level providers are government trained and accredited to do first-trimester abortions. METHODS: We did a randomised, two-sided controlled equivalence trial to compare rates of complication in abortions done by the two groups of providers. An a-priori margin of equivalence of 4.5% with 80% power and 95% CI (alpha=0.05) was used. 1160 women participated in South Africa and 1734 in Vietnam. Women presenting for an induced abortion at up to 12 weeks' gestation were randomly assigned to a doctor or a mid-level provider for manual vacuum aspiration and followed-up 1014 days later. The primary outcome was complication of abortion. Complications were recorded during the abortion procedure, before discharge from the clinic, and at follow-up. Per-protocol and intention-to-treat analyses were done. This trial is registered at with the identifier . FINDINGS: In both countries, rates of complication satisfied the predetermined statistical criteria for equivalence: rates per 100 patients in South Africa were 1.4 (eight of 576) for midlevel providers and 0 for doctors (difference 1.4, 95% CI 0.4 to 2.7); in Vietnam, rates were 1.2 (ten of 824) for mid-level providers and 1.2 (ten of 812) for doctors (difference 0.0, 95% CI -1.2 to 1.1). There was one immediate complication related to analgesics. Delayed complications were caused by retained products and infection. INTERPRETATION: With appropriate government training, mid-level health-care providers can provide first trimester manual vacuum aspiration abortions as safely as doctors can. Publication Type Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, NonU.S. Gov't. <13> Unique Identifier 16909172 Status MEDLINE Authors Morroni C. Moodley J. Authors Full Name Morroni, Chelsea. Moodley, Jennifer. Title Characteristics of clients seeking first- and second-trimester terminations of pregnancy in public health facilities in Cape Town. Source South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde. 96(7):574, 2006 Jul. Publication Type Letter. <14> Unique Identifier 16366017 Status MEDLINE Authors International Consortium for Medical Abortion. Authors Full Name International Consortium for Medical Abortion. Title Medical abortion: expanding access to safe abortion and saving women's lives. [0 refs] Source Reproductive Health Matters. 13(26):11-2, 2005 Nov. Publication Type Consensus Development Conference. Editorial. <15> Unique Identifier 16291484 Status MEDLINE Authors Cooper D. Dickson K. Blanchard K. Cullingworth L. Mavimbela N. von Mollendorf C. van Bogaert L. Winikoff B. Authors Full Name Cooper, Diane. Dickson, Kim. Blanchard, Kelly. Cullingworth, Lee. Mavimbela, Nqobile. von Mollendorf, Clare. van Bogaert, Louis. Winikoff, Beverly. Institution Women's Health Research Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. Title Medical abortion: the possibilities for introduction in the public sector in South Africa. Source Reproductive Health Matters. 13(26):35-43, 2005 Nov. Abstract Medical abortion is safe and effective and has been approved for use in early termination of pregnancy in South Africa since 2001. The Department of Health is currently considering its introduction in the public health sector. The attitudes of women seeking abortion and of health care providers towards medical abortion have not previously been described. Data were derived from a quantitative survey of 673 women attending abortion services in the provinces of Gauteng, Mpumalanga and the Western Cape. In-depth interviews in Soweto and Cape Town were conducted with 20 public health doctors, nurses, a social worker and facility managers, and in Cape Town with four provincial policymakers. Although medical abortion was not yet being offered, 21% of women interviewed were early enough in pregnancy (eight weeks or less) to be eligible for medical abortion. Access to health facilities, including those for abortion, was reasonable for urban women but more limited for rural women. Rural women also incurred greater travel costs to reach a facility. Most women thought medical abortion would be acceptable and would have been willing to try it, had it been available. Policymakers and providers were supportive, as they felt medical abortion could relieve the burden on current services. How to increase access to abortion services in rural areas needs to be addressed. Publication Type Journal Article. Research Support, Non-U.S. Gov't. <16> Unique Identifier 16105333 Status MEDLINE Authors Owolabi OT. Moodley J. Authors Full Name Owolabi, O T. Moodley, J. Institution Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine, Durban, South Africa. Title A randomized trial of pain relief in termination of pregnancy in South Africa. Source Tropical Doctor. 35(3):136-9, 2005 Jul. Abstract The aim of this prospective trial was to evaluate and compare paracervical block with diclofenac for pain relief during manual vacuum aspiration (MVA) for surgical termination of pregnancy. Participants were randomized into three groups, viz. group (i) diclofenac 75 mg intramuscularly (i.m.) 30 min before the procedure; (ii) diclofenac 75 mg i.m. 30 min before the procedure, together with local infiltration of the cervix with lignocaine 1% (10 mL); (iii) diclofenac 75 mg i.m. 30 min before the procedure together with local infiltration of the cervix with lignocaine 1% (10 mL) and paracervical block with lignocaine 1% (5 mL). There was a significant difference in pain scores during the procedure between groups (i) and (ii) (P < 0.001), and between groups (i) and (iii) (P < 0.001) in pain scores during the procedure. There was no difference in pain score between groups (ii) and (iii) (P = 0.144). Post procedure analysis of pain score also showed significant difference between group (i) on one hand, and groups (ii) and (iii) (P < 0.001), but no significant difference between groups (ii) and (iii)(P = 0.029). The local anaesthetic infiltration of the cervix in combination with diclofenac or together with diclofenac and paracervical block provides better pain relief during and after the MVA. Publication Type Clinical Trial. Journal Article. Randomized Controlled Trial. <17> Unique Identifier 16101602 Status MEDLINE Authors Jewkes RK. Gumede T. Westaway MS. Dickson K. Brown H. Rees H. Authors Full Name Jewkes, Rachel K. Gumede, Tebogo. Westaway, Margaret S. Dickson, Kim. Brown, Heather. Rees, Helen. Institution Gender and Health Research Unit, Medical Research Council, Pretoria, South Africa. Title Why are women still aborting outside designated facilities in metropolitan South Africa?. Source BJOG: An International Journal of Obstetrics & Gynaecology. 112(9):1236-42, 2005 Sep. Abstract OBJECTIVE: To explore why South African women still abort outside designated services where there is substantial legal service provision. DESIGN: Descriptive study. SETTING: Three hospitals in Gauteng Province in South Africa. Sample Forty-six women attending hospital with incomplete abortion who had abortions induced outside of designated facilities. METHODS: An interviewer-administered questionnaire with open and closed questions was completed. Induction status was determined from answers to a set of closed questions. Open-ended questions explored the circumstances of induction. Main focus of interviews Methods of induction used, barriers to legal service use. RESULTS: Nearly two-thirds of women (n= 38) had self-induced or had consulted a traditional healer. A minority of these women (n= 11) indicated that they did this because they experienced barriers to legal service use. For others it was presented as a 'natural' response to a health problem (unwanted pregnancy). Several women (n= 10) were given misoprostol by a doctor, nurse, or pharmacist. Fifty-four percent of the women had not used legal services because they did not know about the law, while 15% knew of their legal rights, but did not know of a legal facility. Others did know where to access legal services but feared rude staff (17%) or breaches of confidentiality (6.5%). Others (6.5%) had been unable to get a legal abortion early enough in pregnancy to comply with the law. CONCLUSIONS: Lack of information on abortion rights under the Act and perceived poor quality of designated facilities were the most important barriers to access and should be addressed by policymakers and health service management. The willingness of women to self-medicate and visit traditional healers in these circumstances may influence the overall ability of the new legislation to reduce abortion morbidity. Publication Type Journal Article. Multicenter Study. <18> Unique Identifier 15889846 Status MEDLINE Authors Jewkes R. Rees H. Authors Full Name Jewkes, Rachel. Rees, Helen. Title Dramatic decline in abortion mortality due to the Choice on Termination of Pregnancy Act. Source South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde. 95(4):250, 2005 Apr. Publication Type Letter. <19> Unique Identifier 15854634 Status MEDLINE Authors le Roux PA. van der Spuy ZM. Authors Full Name le Roux, Paul A. van der Spuy, Zephne M. Institution Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of Cape Town/Groote Schuur Hospital, P.O. Box 34584, Groote Schuur, 7937, Cape Town, South Africa. pleroux@absamail.co.za Title Labor induction abortion utilizing trilostane, a 3beta-hydroxysteroid dehydrogenase inhibitor. Source Contraception. 71(5):343-7, 2005 May. Abstract Labor induction abortion in the second trimester is a difficult problem in developing countries because antiprogestins are either not available or unaffordable. When prostaglandins are used alone for labor induction abortion without antiprogestin pretreatment, the induction to delivery interval and the treatment failure rate increase. Trilostane, an inhibitor of 3beta-hydroxysteroid dehydrogenase enzyme system, was given to 93 women between 13 and 19 weeks gestation. The trilostane dosage used was 120 mg twice daily for the first 24 h, and then 240 mg twice daily for the next 24 h. The women returned after 48 h for hospital admission. The women were randomized to three different misoprostol regimens: low-dose vaginal group (200 microg every 4 h), high-dose vaginal group (initial dose of 400 microg followed by 200 microg every 4 h) and vaginal-oral group (400 microg vaginally followed by 200 microg orally every 4 h). The median induction to abortion times were 17, 8.3 and 9.4 h, respectively. The latter two groups had significantly shorter induction to delivery times (p<.05). The most common side effects were a burning feeling in the face (47.7%) and nausea (13.3%). Overall, trilostane side effects were mild and self-limiting and did not interfere with therapy. In conclusion, trilostane can be given as outpatient therapy prior to admission for prostaglandin administration in labor induction abortion. Publication Type Clinical Trial. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't. <20> Unique Identifier 15532749 Status MEDLINE Authors Bateman C. Authors Full Name Bateman, Chris. Title Kopanong in a spin over TOP. Source South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde. 94(10):808-9, 2004 Oct. Publication Type News. <21> Unique Identifier 12638811 Status MEDLINE Authors Buga GA. Authors Full Name Buga, G A B. Institution University of Transkei, Private Bag X01, Unitra, Umtata, South Africa. Title Attitudes of medical students to induced abortion. Source East African Medical Journal. 79(5):259-62, 2002 May. Abstract BACKGROUND: Unsafe abortion causes 13% of maternal deaths worldwide. Safe abortion can only be offered under conditions where legislation has been passed for legal termination of unwanted pregnancy. Where such legislation exists, accessibility of safe abortion depends on the attitudes of doctors and other healthcare workers to induced abortion. Medical students as future doctors may have attitudes to abortion that will affect the provision of safe abortion. Little is known about the attitudes of South African medical students to abortion. OBJECTIVES: To assess sexual practices and attitudes of medical students to induced abortion and to determine some of the factors that may influence these attitudes. DESIGN: A cross-sectional analytic study involving the self-administration of an anonymous questionnaire. SETTING: The questionnaire was administered to medical students at a small, but growing, medical school situated in rural South Africa. MAIN OUTCOME MEASURES: Demographic data, sexual practices and attitudes to induced abortion. RESULTS: Two hundred and forty seven out of 300 (82.3%) medical students responded. Their mean age was 21.81 +/- 3.36 (SD) years, and 78.8% were Christians, 17.1% Hindus and 2.6% Muslims. Although 95% of the respondents were single, 68.6% were already sexually experienced, and their mean age at coitarche was 17.24+/-3.14 (SD) years. Although overall 61.2% of the respondents felt abortion is murder either at conception or later, the majority (87.2%) would perform or refer a woman for abortion under certain circumstances. These circumstances, in descending order of frequency, include: threat to mother's life (74.1%), in case of rape (62.3%), the baby is severely malformed (59.5%), threat to mother's mental health (53.8%) and parental incompetence (21.0%). Only 12.5% of respondents would perform or refer for abortion on demand, 12.8% would neither perform nor refer for abortion under any circumstances. Religious affiliation and service attendance significantly influenced some of these attitudes and beliefs. CONCLUSION: Although many of the medical students personally felt abortion is murder, the majority are likely to perform or refer patients for abortion under certain circumstances; only about a tenth are likely to perform or refer patients for abortion on demand. Publication Type Journal Article. <22> Unique Identifier 12553186 Status MEDLINE Authors Varga CA. Authors Full Name Varga, Christine A. Institution Child, Youth, and Family Development, Human Sciences Research Council, Durban, South Africa. cvarga@hsrc.ac.za Title Pregnancy termination among South African adolescents. Source Studies in Family Planning. 33(4):283-98, 2002 Dec. Abstract Although African adolescents' risk of undergoing abortion and of related health complications is well-documented, little is known about the procedure's prominence in their lives and the pathways that lead to their reliance upon it. This study investigates abortion dynamics among male and female Zulu adolescents in KwaZulu/Natal, South Africa. It explores the role of abortion in young people's sexual and reproductive experience, its acceptability, the reasons and likelihood of young people's choosing abortion, and the commonly used methods of pregnancy termination. The study, a rural-urban comparison using focus-group discussions, narrative workshops, and role playing, involved surveys and in-depth interviews. Factors contributing to the commonplace nature of backstreet procedures among adolescents include: social stigma, inadequate knowledge of the legal status of abortion, and a complex group decisionmaking process. Young people invoke "relative moralities" concerning adolescent abortion, recognizing and condoning it on a context-specific basis. Age, gender, and geographic differences are examined. The methodological triangulation used offers the opportunity for alternative theoretical and methodological approaches to research on abortion-related issues. Publication Type Comparative Study. Journal Article. <23> Unique Identifier 12146118 Status MEDLINE Authors Bateman C. Authors Full Name Bateman, Chris. Title Department to take up GP abortion offer. Source South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde. 92(6):406-7, 2002 Jun. Publication Type News. <24> Unique Identifier 11993259 Status MEDLINE Authors Jali MN. Authors Full Name Jali, M N. Institution Department of Nursing Science, University of the North. Title Abortion--a philosophical perspective. [Review] [8 refs] Source Curationis. 24(4):25-31, 2001 Nov. Abstract The central issue in the abortion debate is the moral status of the conceptus. There are two positions that argue this issue. At one extreme are the views of the pro-life group which argues that human life begins at the moment of conception whilst at the other are views of the pro-choice group that argues in favour of a woman's right to self-determination. Two basic principles come into conflict in this debate, namely the Value of Life and that of Self-determination. In this paper the arguments forwarded by each group in justification of its position are presented. Also discussed is the moderate developmental viewpoint which accepts that the genetic basis of an individual is established at conception. Some development, however, has to occur before the conceptus can be called a person. The fact that an entity is a potential person is a prima facie reason for not destroying it. On the other hand, we need not conclude that a person has a right to life by virtue of that potentiality. Simultaneously we should recognise that the right a potential entity has, may be nullified by the woman's right to self-determination. [References: 8] Publication Type Journal Article. Review. <25> Unique Identifier 11140033 Status MEDLINE Authors Gmeiner AC. Van Wyk S. Poggenpoel M. Myburgh CP. Authors Full Name Gmeiner, A C. Van Wyk, S. Poggenpoel, M. Myburgh, C P. Title Support for nurses directly involved with women who chose to terminate a pregnancy. Source Curationis. 23(1):70-8, 2000 Mar. Abstract Research conducted by Poggenpoel, Myburgh and Gmeiner (1998:2-8) on "One voice regarding the legalization of abortion: Nurses who experience discomfort" indicated that the nurses were in favour of the fact that nurses should volunteer to participate in terminating a pregnancy of a woman. From our observations in clinics where nurses voluntarily participate in providing reproductive health services, including termination of pregnancy, it became clear that supporting these nurses may be essential. To be able to provide support, it is necessary to identify, explore and describe nurses' experience of being directly involved with women who terminate their pregnancy. To enable us to address the identified problems, a qualitative research strategy was implemented in which respondents were included in the sample through purposive sampling. Phenomenological interviews were conducted individually. Data was analyzed by means of Tesch's descriptive approach. Thereafter, guidelines for operationalization were inferred from the results and a literature control completed to verify and enrich guidelines. Measures to ensure trustworthiness have been applied in the research and ethical measures have been strictly adhered to regarding this sensitive issue. Publication Type Journal Article. <26> Unique Identifier 12425313 Status MEDLINE Authors Slabbert MN. Authors Full Name Slabbert, M N. Institution Department of Jurisprudence, University of South Africa. Title The position of the human embryo and foetus in international law and its relevance for the South African context. Source Comparative & International Law Journal of Southern Africa. 32(3):336-53, 1999 Nov. Other ID Source: KIE. 105234 Source: NRCBL. VF 9.5.8 Publication Type Journal Article. <27> Unique Identifier 12294838 Status MEDLINE Authors Becker B. Authors Full Name Becker, B. Title 78,000 women die each year from unsafe abortions worldwide. It is estimated that there are 20 million unsafe abortions per year on a global basis. Source Reproductive Freedom News. 8(3):1, 5, 1999 Mar. Other ID Source: PIP. 140297 Source: POP. 00283822 Other Abstract At February's Cairo+5 proceedings at the Hague, the Center for Reproductive Law and Policy (CRLP) called a press conference to discuss changes in abortion laws around the world since the International Conference on Population and Development in Cairo in 1994. According to the director of CRLP's International Program, 9 countries have modified their abortion laws since Cairo. Of those, 7 liberalized their laws, while Poland and El Salvador further restricted legislation. The CRLP supports the liberalization of abortion laws for all women in all countries. Abortion law has been liberalized in South Africa since Cairo, with the enactment in 1997 of the Termination of Pregnancy Act. In contrast, however, anti-choice groups in Poland successfully challenged the legality of abortion in 1996 by declaring it against the Polish Constitution. Abortion is prohibited in Chile in all circumstances, even to save the life of the woman. However, despite the illegality of abortion in that country, half of all pregnancies in Chile end in abortion. Unsafe abortion contributes to the 50% maternal mortality rate in Nepal. Abortion in the country is punishable by a 20-year prison sentence, regardless of the age of the woman. Publication Type Journal Article. <28> Unique Identifier 10734504 Status MEDLINE Authors Okanlomo KA. Ngotho D. Moodley J. Authors Full Name Okanlomo, K A. Ngotho, D. Moodley, J. Institution Department of Obstetrics and Gynaecology, University of Natal Medical School, Durban, South Africa. Title Effect of misoprostol for cervical ripening prior to pregnancy interruption before twelve weeks of gestation. Source East African Medical Journal. 76(10):552-5, 1999 Oct. Abstract BACKGROUND: Liberalization of the law in respect of legal abortions has led to a search for an appropriate technique for termination of pregnancy. The technique should be cheap, easy to perform and have minimal or no complications. AIM: To evaluate the effectiveness of performing manual vacuum aspiration (MVA) with and without the use of misoprostol to the procedure. DESIGN: Randomised control study. SETTING: Obstetrics and Gynaecology Department, University of Natal Medical School, South Africa. RESULTS: One hundred and thirty six women were recruited; 70 women were assigned to the misoprostol group. Of these, 11 (15%) did not show any change in cervical score. Their mean cervical dilatation was similar to the control group (3.3 versus 31; p > 0.06). In the group whose gestational age was less than eight weeks, the time taken to complete the procedure, quantity of products of conception and cervical dilatation, were different from that of the control group, and this reached statistical significance except quantity of products of conception in primigravidae. In pregnancies greater than eight weeks gestation, all parameters assessed, such as cervical dilatation, quantity of products of conception was significantly different from the control group, in both multi- and primigravidae. Pain score was similar for all gestations. CONCLUSION: Misoprostol is of specific value during MVA for voluntary interruption of pregnancy. Publication Type Clinical Trial. Journal Article. Randomized Controlled Trial. <29> Unique Identifier 11645069 Status MEDLINE Authors Sidley P. Authors Full Name Sidley, Pat. Title South Africa's liberal abortion laws challenged. Source BMJ. 316(7146):1696, 1998 Jun 6. Other ID Source: KIE. 58244 Source: NLM. PMC1174780 Publication Type Journal Article. News. <30> Unique Identifier 9418421 Status MEDLINE Authors Maforah F. Wood K. Jewkes R. Authors Full Name Maforah, F. Wood, K. Jewkes, R. Institution National Urbanisation and Health Programme, Medical Research Council, Parow. Title Backstreet abortion: women's experiences. Source Curationis. 20(2):79-82, 1997 Jul. Other ID Source: PIP. 131497 Source: POP. 00276871 Abstract AIM: This was a descriptive study aimed at exploring the personal experiences of women who induce abortion and the circumstances surrounding induced abortion. METHODS: The study was conducted in six public hospitals in four different provinces: Baragwanath (Gauteng), Groote Schuur and Tygerberg (Western Cape), King Edward and R.K. Khan (Kwa-Zulu/Natal) and Livingstone (Eastern Cape). In-depth interviews were conducted with 25 African, Indian and Coloured women admitted to the hospitals following backstreet abortions. The study gave women the opportunity to "speak for themselves" about "why" and "how" and the context in which the unsafe induced abortions occurred. RESULTS: The findings show that a host of factors were important in the circumstances leading to unwanted pregnancy and induced abortion: socioeconomic, cultural, psychological and societal. Disempowerment in relationships combined with financial pressures constituted the background as to why women felt forced to terminate their pregnancies. The perceived need for termination was found to over-ride all other considerations, including religious ones. The ways in which women attempted to procure abortion, both through legal and illegal routes, are presented. Wider social and legal discourses an abortion were found to be an important factor in how women experienced their situation. Other Abstract In order to determine why and how women in South Africa obtain illegal abortions, a descriptive study was conducted in six public hospitals in four provinces. Data were gathered via semi-structured, in-depth interviews with 25 women hospitalized with complications of selfconfessed induced abortion (64% Africa, 20% Indian, and 16% Colored). 3 of the 5 married women were separated from their husbands. Almost half of the subjects were adolescents, and the mean age was 25 years. All of the women were aware of contraceptives but failed to use them or used them improperly. In some cases, the male partners disapproved of contraception or initiated intercourse in such a way that disempowered the women, making them unable to negotiate contraceptive usage. Most of the women felt they had no choice but to seek abortion because their sexual relationships or financial circumstances were unstable. The compulsion to seek abortion overrode all legal and religious considerations. The women, who had to self-induce or seek illegal abortion, felt that the current law placed a tremendous burden on them at a time of extreme trauma. The women also complained about their treatment at the hands of the abortionists and, later, by the hospital staff. Thus, the 1975 abortion and Sterilization Act has failed to limit the number of abortions. The law should be amended to make abortion accessible, safe, and less expensive to obtain. In addition, men should be targeted recipients of family planning and contraception information. Publication Type Journal Article. <31> Unique Identifier 9322338 Status MEDLINE Authors Jewkes RK. Fawcus S. Rees H. Lombard CJ. Katzenellenbogen J. Authors Full Name Jewkes, R K. Fawcus, S. Rees, H. Lombard, C J. Katzenellenbogen, J. Institution CERSA-Women's Health, Centre for Epidemiological Research in Southern Africa, Medical Research Council, Pretoria, South Africa. Title Methodological issues in the South African incomplete abortion study. Source Studies in Family Planning. 28(3):228-34, 1997 Sep. Other ID Source: PIP. 127970 Source: POP. 00269148 Abstract In 1994, a national hospital-based study was undertaken of cases of incomplete abortion presenting to public hospitals in South Africa. Data were collected for all women admitted to a random sample of hospitals with incomplete abortion during a two-week period. The WHO protocol for such studies was used as a basis for developing the methods to describe the epidemiology of incomplete abortion and hospital management of cases. Attempts were made to estimate the proportion of cases that might have been induced. This report focuses on methodological issues arising from the study that have implications for future research. The findings demonstrate that only a small proportion of the women acknowledged having had an induced abortion and that only a few of those who did showed evidence of interference with pregnancy. Clinical opinion of sepsis and the likelihood of induction were found to be highly unreliable. These findings considerably reduce the usefulness of the WHO-protocol method of estimating the likely origin of incomplete abortions. Results presented in terms of three partially overlapping descriptive categories are judged to better reflect the limitations of the data collected. Publication Type Journal Article. Research Support, Non-U.S. Gov't. <32> Unique Identifier 9254779 Status MEDLINE Authors Jewkes RK. Wood K. Maforah NF. Authors Full Name Jewkes, R K. Wood, K. Maforah, N F. Title Backstreet abortion in South Africa. Comments Comment on: S Afr Med J. 1997 Apr;87(4):432-7; PMID: 9254785] Source South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde. 87(4):417-8, 1997 Apr. Other ID Source: KIE. 64771 Source: NRCBL. 12.1 Publication Type Comment. Editorial. Historical Article. <33> Unique Identifier 12321538 Status MEDLINE Authors Suffla S. Authors Full Name Suffla, S. Title Experiences of induced abortion among a group of South African women. Source South African Journal of Psychology. 27(4):214-22, 1997 Dec. Other ID Source: PIP. 132529 Source: POP. 00276345 Other Abstract In-depth interviews were conducted with five single South African women 20-31 years of age of varying socioeconomic backgrounds who underwent illegal induced abortion before implementation in 1996 of the Choice on Termination of Pregnancy Act. The group included two students, a clerk, a factory worker, and a social worker. Of particular interest were the social context of the abortion decision, the abortion procedure itself, the psychological impact of the abortion, and perceptions of coping. Overall, the interviews indicated that the abortion decision is multidimensional and characterized by some degree of ambivalence. The decision to abort was based on lack of readiness to be a parent, financial hardships, pressure from the father, and fear of disapproval on the part of family members. The manner in which women responded to the abortion was a joint function of their psychological state and the social environment in which the procedure occurred. Although relief was the most common postabortion psychological response, feelings of guilt, shame, and loss also were present. Postabortion adjustment was positively influenced by the perception of support from one's partner. Further studies of this type are urged to help South African health providers to develop a framework for abortion counseling aimed at minimizing postabortion psychological distress. Publication Type Journal Article. <34> Unique Identifier 12292776 Status MEDLINE Authors Gerhardt AJ. Authors Full Name Gerhardt, A J. Title Abortion laws into action: implementing legal reform. Source Initiatives in Reproductive Health Policy. 2(1):1-3, 1997 Jan. Other ID Source: PIP. 128242 Source: POP. 00269768 Other Abstract The worldwide trend towards liberalizing abortion laws has resulted in reduced abortionrelated mortality in areas where legal abortion is accessible. In countries considering abortion reform, policy-makers and health care providers have a responsibility to ensure that provisions of any new law can be met. Preparations underway to prepare for South Africa's new abortion law can serve as a guideline for such action. A new abortion law calls for policy changes that may include 1) developing new standards, protocols, and guidelines for abortion care services; 2) ensuring provision of adequate trained staff willing to provide abortions; 3) streamlining administrative regulations to avoid delays; 4) establishing regulations and mechanisms for drug and equipment supply and distribution; 5) restructuring the health system to accommodate provision of abortion services; 6) allocating funds for new abortion services; and 7) reviewing and revising security measures. In addition, health professionals will require training in abortion provision, staff will need information updates about aspects of the legislation, and administrators and providers in a position to impede provision of services must be made aware of the affect of unsafe abortion on maternal health. Researchers should document the effect of the new law on women's health, the provision of reproductive health services, and the community. IEC (information, education, communication) activities will be required to inform the public about the new law and services, establish sex education programs in schools and health facilities, and mobilize family planning organizations and programs to help reduce the incidence of repeat abortions. Publication Type Journal Article. <35> Unique Identifier 11656779 Status MEDLINE Authors South Africa. Authors Full Name South Africa. Title An act (No. 92 of 1996) to determine the circumstances in which and conditions under which the pregnancy of a woman may be terminated; and to provide for matters connected therewith. Date of assent: 12 Nov 1996. (The Choice on Termination of Pregnancy Act, 1996). (Government Gazette, 22 Nov 1996, Vol 377, No. 17602, pp. 1-10). Source International Digest of Health Legislation. 48(2):178-81, 1997. Other ID Source: KIE. 59593 Publication Type Legislation. <36> Unique Identifier 11654533 Status MEDLINE Authors Lee NC. Authors Full Name Lee, N C. Title Sweeping changes made to South Africa's abortion law. Source Lancet. 348(9037):1304, 1996 Nov 9. Other ID Source: KIE. 52993 Publication Type Journal Article. News.