The Urinary System Chapter 23 • Consists of: 2 kidneys, 2 ureters, 1 urinary bladder, 1 urethra • Major function: kidneys filter blood and restore water and solutes to bloodstream. Remaining water and solutes are voided of body. Function • Regulates blood volume and composition – Removes wastes such as protein wastes (ammonia, urea), nucleic acid waste (uric acid), excess water, and other ions to form urine. • Regulation of blood pressure – Kidney secretes renin, an enzyme that increases blood pressure and volume. Other Functions • Produces erythropoietin – a hormone that stimulates red blood cell production in bone marrow. • Metabolizes vitamin D to its active form. Kidney enclosed in 3 layers Renal capsule – tough fibrous tissue that adheres directly to kidney surface and is continuous with outer coat of ureter. Kidney enclosed in 3 layers Adipose capsule – provides protection from trauma and keeps kidney in place Kidney enclosed in 3 layers Renal fascia – thin outer layer of dense, irregular C.T. that anchors kidney to abdominal wall, peritoneum, and other structures. 2 distinct regions of the kidney are: cortex and renal medulla Cortex – outer edge of kidney, delineated by renal pyramid Medulla – deep inner portion of kidney Renal pyramid – cone-shaped structures, the apex of each points toward the renal sinus, where its papilla communicate with minor calyx. Renal pelvis – ureter expands and widens into kidney to form funnel shaped sac. Subdivided into minor and major calyx. These structures collect urine from the renal papilla located in the renal pyramids. renal artery segmental artery lobar artery interlobar artery arcuate artery interlobular artery afferent arteriole glomerulus (capillaries) renal vein interlobar vein arcuate vein interlobular vein peritubular capillaries and vasa recta efferent arteriole 1. Arterial flow – renal artery, segmental artery, lobar artery, interlobar artery, arcuate artery, interlobular artery, afferent arteriole. 2. Glomerular tubular flow – glomerular capillaries, efferent arteriole, peritubular capillaries/vasa recta 3. Venous flow – interlobular veins, arcuate veins, interlobar veins, renal vein Nephrons • Urine producing units of the kidney • 2 components: – renal corpuscle • glomerulus surrounded by thin-walled sac called the glomerular (Bowman’s) capsule. – renal tubule Nephrons Perform 3 Functions Overall net effect is to allow wastes to be excreted in concentrated urine and needed materials returned to blood. Juxtaglomerular Apparatus • • The collection of cells near the glomerulus. These cells secrete renin as decreased delivery of water, sodium, and chlorine are detected. This triggers a hormonal response to raise blood pressure, increase blood volume, and blood solute concentration. Summary of Filtration • • • • • Renal corpuscles – filter fluid into tubule containing all solutes in blood • e.g. water, ions, glucose, amino acids, etc. PCT – reabsorption of water, glucose and amino acids, ions – secretion of H+, ammonium ion, urea Loop of Henle – reabsorption of water, ions – secretion of urea DCT – reabsorption of water and ions Late DCT and Collecting Duct – reabsorption of water – secretion of ions Elimination of Urine Ureters & Urinary Bladder • Urine drains into ureters from the renal pelvis and connects to urinary bladder. • Urinary bladder - A hollow, distendable, muscular organ located behind the symphysis pubis in the pelvic cavity. Urethra – small tube leading from the internal urethra orifice in the floor of the bladder to the exterior of the body. Females – urethera about 4cm long and passes posteriorly to the pubic symphysis and opens to the exterior between the clitoris and the vagina. Males – urethra functions as the urinary canal and reproductive canal for sperm and associated secretions. Prostatic urethra – about 2.5 cm long and passes through the prostate gland. Ducts from reproductive structures also pass through the prostate and join urethra. Membranous urethra – about 2cm long and passes through the urogenital diaphragm and is surrounded by external urethral sphincter. Penile (spongy) urethra – about 15 cm long and passes through the corpus spongiosum of the penis, surrounded by erectile tissue. External urethral orifice – where the urethra opens to the outside. Urine Flow • The order of structures urine passes through on its way to the outside world: • Glomerular capsule, PCT, descending limb of loop of Henle, ascending limb of loop of Henle, DCT, collecting tubule, papillary duct of renal papillae, minor calyx, major calyx, renal pelvis, ureter, bladder, urethra.