Research at the Front Lines Finding New Solutions in HIV Prevention, Treatment and Support HILTON TORONTO November 16, 17, 2009 1 Cover Art: HIV, Luke Jerram, Glass Microbiology www.lukejerram.com November 2009 Welcome Delegates, Welcome to the 11th Annual Ontario HIV Treatment Network Research Conference: Research at the Front Lines: Finding New Solutions in HIV Prevention, Treatment and Care. The 2009 conference will showcase research that examines the factors that increase vulnerability and risk for individuals and communities disproportionately affected by HIV, and the interventions that may lead to more resiliency and improve quality of life for individuals and communities. Using an interdisciplinary approach and working at the intersections of social science, population health and health services, the research presented at the conference will focus on: Strengthening Community by understanding the problems and factors driving the epidemic Promoting Research that finds innovative and practical solutions by developing evidence and science-based HIV interventions Driving Change by moving research evidence into action with a measurable impact on policy and practice The Conference Planning Committee has assembled a dynamic group of international speakers including: Jonathan Anderson, an HIV clinician from Australia who has a special interest in public health, particularly health economics; Ron Stall, whose research focuses on HIV prevention and behavioural epidemiology of gay men; Charles Collins, an expert in the Diffusion of Effective Behavioural Intervention Program in the United States; Bonita Stanton and Lynette Deveaux, who worked together to bring a US-based prevention intervention for youth to the Caribbean; and Robert Carr, who works with International Council of AIDS Service Organizations to mobilize community organizations to build an effective response to HIV prevention, treatment, care and support for those living with and affected by HIV/AIDS. Physicians, scientists and researchers conducting innovative studies in Canada and speaking at the conference include: Mario Ostrowski and Juan Carlos Zúñiga-Pflücker, scientists who are making breakthroughs in understanding HIV at the cellular level; Alan Li, an HIV primary care physician and co-chair of the Committee for Accessible AIDS Treatment; Marina Klein, a physician at McGill University Health Centre specializing in HIV/HCV co-infection; and Thomas Kerr, a research scientist with the BC Centre for Excellence in HIV/AIDS with a focus on injection drug users, HIV positive individuals and street-involved youth. We hope that the diverse group of speakers will ignite discussion and help us develop innovative, evidence-based interventions in Ontario and across Canada. The OHTN gratefully acknowledges the members of the abstract review committee who helped develop the conference program and reviewed over 200 abstracts submitted to the conference this year. We are also very appreciative of the generous contributions made by our industry sponsors. Yours Sincerely, SEAN B. ROURKE, PH.D. Scientific and Executive Director, OHTN Associate Professor, University of Toronto Scientist, CRICH, St. Michael’s Hospital DARIEN TAYLOR Conference Co-Chair Director, Program Delivery Canadian AIDS Treatment Information Exchange EVAN COLLINS President Ontario HIV Treatment Network Board of Directors OHTN Board of Directors Officers Evan Collins, President Lynne Leonard, Vice-President Ken Logue, Secretary Neil McGregor, Treasurer Community Members Lisungu Chieza Evan Collins Michael Hamilton Peter Hayes Neil McGregor LaVerne Monette Darryl Perry Outpatient Clinic Directors and Coordinators Leonard Moore Primary Care Physicians Ken Logue Linda Robinson Meaghan McLaren Researchers Rupert Kaul Lynne Leonard 2 Ontario Drug Distribution Monitoring Program (Ex-Officio) Anita Rachlis Ontario Ministry of Health and Long-Term Care (Ex-Officio) Leio J. Coloquio Ontario AIDS Network (Ex-Officio) Rick Kennedy Honorary Director Jay Browne Frank McGee RESEARCH AT THE FRONT LINES Conference Sponsors PLATINUM GOLD BRONZE CONTRIBUTOR Finding New Solutions in HIV Prevention, Treatment and Support 3 Collaborating Partners CACVO Le conseil des africains et caraïbeens sur le VIH/SIDA en Ontario ACCHO African and Caribbean Council on HIV/AIDS in Ontario Ontario AIDS Network 4 RESEARCH AT THE FRONT LINES Conference Map HILTON TORONTO CONVENTION LEVEL CARMICHAEL JACKSON washrooms SPEAKER READY ROOM TORONTO l REGISTRATION coat check foyer TOM THOMSON guest elevators HARRIS CASSON MACDONALD TORONTO ll LISMER JOHNSON Finding New Solutions in HIV Prevention, Treatment and Support 5 Program at a Glance Monday, November 16, 2009 8:00 8:30 am Registration / Breakfast 8:30 9:45 am Toronto I & II Welcome Panel: Shaping the Research that Affects Us: Experience of People with HIV in Research 9:45 10:45 am Toronto I & II PLENARY: Building the Case for Effective Interventions Speakers: Jonathan Anderson and Ron Stall 10:45 11:30 am Foyer 11:30 12:30 pm Harris MacDonald Special Session Trans PULSE Oral Abstracts Special Session No Health Without The MaBwana Mental Health Study 12:30 1:30 pm Break / Poster Viewing Lismer Carm/Jackson Tom Thomson Oral Abstracts When the Law Steps In Oral Abstracts Complex Treatment Challenges Lunch CIHR Centre for REACH in HIV/AIDS Focus on Intervention Research, Sean B. Rourke CIHR Centre in HIV Prevention Social Research, Liviana Calzavara 1:30 2:30 pm Toronto I & II PLENARY: Prevention Interventions Beyond Our Borders Speakers: Robert Carr and Charles Collins 2:45 3:45 pm Harris MacDonald Lismer Carm/Jackson Tom Thomson Toronto I & II Oral Abstracts What Makes T-Cells Tick? Special Session HIV & Youth ArtsBased Approaches Film Screening Co-infection Documentary Oral Abstracts Front Line Care Oral Abstracts Reducing Risk in Gay Men and Other MSM Special Session DEBIs in Depth 4:00 4:45 pm Toronto I & II Dr. Susan King Lecture — Focus on Youth: Taking a DEBI from Baltimore to the Bahamas Speakers: Bonita Stanton and Lynette Deveaux 4:45 5:45 pm Toronto I & II 6:00 7:00 pm Tom Thomson Lismer Innovations for PHAs HIV Epidemic in Ukraine 6:00 8:00 pm Reception 6 Panel: Prevention Interventions Within Our Borders RESEARCH AT THE FRONT LINES Program at a Glance Tuesday, November 17, 2009 8:00 8:30 am Registration / Breakfast 8:30 10:15 am Toronto I & II PLENARY: Cellular Interventions and Clinical Care Speakers: Mario Ostrowski, Juan Carlos Zúñiga-Pflücker and Marina Klein 10:30 11:30 am Toronto I & II MacDonald Foyer Carm/Jackson Tom Thomson Special Session Focus on Youth: Caribbean Partnership Web Tours Poster Viewing Special Session HIV, Housing and Health Special Session HIV Stigma Campaign 11:30 - am 12:30 pm Harris Oral Abstracts Reaching High Risk Youth in Smaller Urban Centres MacDonald Lismer Carm/Jackson Tom Thomson Oral Abstracts Outsmarting the Virus Film Screening FIX: The Story of an Addicted City STARTS at 11:00 am Oral Abstracts One Size Does Not Fit All: Women & HIV Oral Abstracts Trials and Tribulations of HAART 12:30 1:30 pm Lunch 1:30 2:30 pm Toronto I & II Jay Browne Living Legacy Award Presentation PLENARY: How Research Can Drive Change Researcher as Advocate Speaker: Thomas Kerr Dr. Charles Roy Lecture: Involved, Invested and Inspired: Shared Leadership and Collective Empowerment in the Third Space of Research-Policy-Practice Speaker: Alan Li 2:45 3:45 pm Harris MacDonald Lismer Carm/Jackson Tom Thomson Oral Abstracts For Mature Audiences Only Oral Abstracts The Fight for Immunity Special Session Intervening in Theory, Methods and Practice Oral Abstracts Where There’s Smoke… Oral Abstracts Cultural Insights 4:00 5:00 pm Harris MacDonald Lismer Carm/Jackson Tom Thomson Oral Abstracts On the International Front Oral Abstracts What a Teen Wants, What a Teen Needs Special Session Innovative PHA Skill Building Strategies Oral Abstracts Knowing What Works Oral Abstracts A Dose of Reality Finding New Solutions in HIV Prevention, Treatment and Support 7 Full Program Monday, November 16, 2009 8:00 am Foyer Registration and Breakfast 8:45 am Toronto I & II Welcome and Opening Remarks 9:00 am Toronto I & II Shaping the Research that Affects Us: Experience of People with HIV in Research Sean B. Rourke and Darien Taylor, Conference Co-Chairs Ontario researchers working in academia realize the value of engaging the community in their work and have benefited from the partnership but what have community members gained from being involved in research? People with HIV who are actively involved in research describe the impact their involvement has on their work and their lives. Speakers Marisol Desbiens, Latino Positivo Randy Jackson, Canadian Aboriginal AIDS Network, McMaster University James Watson, Positive Spaces Healthy Places Lisungu Chieza, Women’s Health in Women’s Hands, U of T HIV Research Ethics Board Moderator Darien Taylor, Canadian AIDS Treatment Information Exchange, U of T HIV Research Ethics Board 9:45 am Toronto I & II PLENARY: Building the Case for Effective Interventions Is it Worth It? Evaluating the Cost-effectiveness of HIV Interventions Jonathan Anderson, University of Sydney Medical School Rising rates of HIV in Australia have prompted calls for the introduction of new prevention technologies; however, competing demands on limited resources have prompted vigorous debate on their widespread introduction. The Assessing Cost-Effectiveness in HIV project (ACE-HIV), a group of national stakeholders from government, community, clinicians and academics selected prevention and healthcare interventions for a series of economic evaluation focused on evidence of effectiveness, benefits and cost and non-economic factors such as equity, ethics, culture, feasibility and acceptability. The economic evaluation results showed that some of the newer prevention technologies such as circumcision and pre-exposure prophylaxis have the potential to be cost-effective or even cost-saving. Needle syringe programs are cost-saving and could be doubled in scale and still save money. On the other hand, established programs such as non-occupational post-exposure prophylaxis are not good value for money in their current form. The ACE-HIV project helped inform policy and decision making on priorities for research and implementation of new prevention technologies. Early antiretrovirals for prevention, adult male circumcision and pre-exposure prophylaxis could be valuable as part of a combination prevention program for HIV, but require careful consideration of all the issues before widespread adoption. 8 RESEARCH AT THE FRONT LINES Full Program Monday, November 16, 2009 10:15 am Toronto I & II PLENARY: Building the Case for Effective Interventions The Implications of Syndemics and Strengths on Increasing HIV Intervention Efficacy among Gay Men Ron Stall, Graduate School of Public Health, University of Pittsburgh The bulk of the research that has been done on gay men focuses on the health implications of sexual risk behaviors, even though it is now well known that there are multiple epidemics for which gay men have higher prevalence rates than their heterosexual male counterparts. This presentation will present evidence to document some of these health disparities as well as a theory to explain why these disparities exist. Data that have now been collected to test the theory will be presented. The presentation will end with a discussion of the importance of resilience or strengths in explaining health profiles among gay men, and why a focus on strengths, rather than vulnerabilities, may be a more productive research agenda in addressing health disparities among gay men. Moderator Frank McGee, AIDS Bureau, Ministry of Health and Long-Term Care 10:45 am Foyer Break and Poster Viewing 11:30 am CONCURRENT SESSIONS Harris Trans PULSE Trans PULSE is an innovative community-based research (CBR) project that responds to problems identified by Ontario’s trans communities regarding access to health and social services. The project represents a working partnership with many groups including community organizations and academic partners. Trans PULSE strives to understand the ways in which social exclusion, cisnormativity (the belief that trans identities or bodies are less authentic or “normal”), and transphobia shape the provision of services for trans people and how these, in turn, affect health. Some of the things that we are studying include income stability, housing discrimination, relationships and family, sexual health, HIV vulnerability, mental health, community connectedness, access to social services, access to health care services, and hormone use. This special session presents preliminary results from the project; lessons learned using respondentdriven sampling in Ontario’s trans communities; and challenges emerging in a CBR project where ‘community control’ is favoured over ‘community engagement’. Speakers Greta Bauer, The University of Western Ontario Michelle Boyce, Diversity Training Live Todd Coleman, The University of Western Ontario Rebecca Hammond, Dalhousie University Jake Pyne, Community Development Consultant Kyle Scanlon, The 519 Church Street Community Centre Robb Travers, Wilfrid Laurier University, University of Toronto Finding New Solutions in HIV Prevention, Treatment and Support 9 Full Program Monday, November 16, 2009 11:30 am CONCURRENT SESSIONS MacDonald No Health Without Mental Health: Improving Access to Mental Health Services for People with HIV People with HIV often face complex medical and social challenges that affect their mental health and can result in depression, trauma and substance use. The strategies presented in this session focus on increasing access to mental health care and support. 101 Adriana Carvalhal The wHEALTH Project: Access to Care and Mental Health Issues of HIV-Positive Women 103 Carlos Rivas Action as a Key Stage of the Theory / Practice Circle: Developing a New Intervention to Treat HIV Diagnosis Related Trauma 104 James Weaver Enhancing Access to Harm Reduction Mental Health Care and Treatment: An HIV Prevention Strategy for High Risk Substance Users Moderator Rick Kennedy, Ontario AIDS Network Lismer The MaBwana Black Men’s Study: Listening to African, Caribbean and Black Gay Men and other Men Who Have Sex With Men The MaBwana Black Men’s Study was the first Canadian study to examine vulnerability to HIV among African, Caribbean and Black gay and bisexual men. The purpose of this special session is to discuss the research and its implications, highlight current epidemiologic trends and HIV prevention efforts with Black gay and bisexual men, and release the MaBwana report— MaBwana: Health, Community and Vulnerability to HIV among African, Caribbean and Black Gay and Bisexual Men in Toronto—to OHTN conference attendees. The MaBwana study was developed as an initiative of the African and Caribbean Council on HIV/AIDS in Ontario (ACCHO), within the framework of the strategy on HIV/AIDS for African and Caribbean communities in Ontario. MaBwana was implemented in 2006-2009 through the AIDS Committee of Toronto. Current Trends in HIV and AIDS among Black MSM in Ontario Robert Remis, University of Toronto Engaging Black Gay Men in HIV Prevention Efforts Trevor Gray, Prisoners HIV/AIDS Support and Action Network MaBwana Background, Highlights and Implications Winston Husbands, AIDS Committee of Toronto Current HIV Prevention Efforts with Black MSM in Toronto Shannon Ryan, Black Coalition for AIDS Prevention Moderator Lydia Makoroka, AIDS Committee of Toronto 10 RESEARCH AT THE FRONT LINES Full Program Monday, November 16, 2009 11:30 am CONCURRENT SESSIONS Carmichael / Jackson When the Law Steps In: Criminalization, Immigration and HIV New research examines the impact of current immigration policies and the criminal code on people with HIV when they enter the country and/or make personal decisions about disclosure. 105 Laura Bisaillon Implications of Mandatory HIV Screening as a Pre-Condition for Immigration to Canada 108 Tamar Rubin Immigrant Women’s Experiences with Immigration Medical Examination HIV Testing 106 Richard Elliot Criminalization Creep: Legal Developments and Community Responses to Criminal Prosecutions for HIV Exposure 107 Glenn Betteridge, Eric Mykhalovskiy The Criminalization of HIV Non-Disclosure in Canada: A Preliminary Analysis of Trends and Patterns Moderator Anne Marie DiCenso, Prisoners HIV/AIDS Action Support Network Tom Thomson Complex Treatment Challenges People with HIV often face a variety of complex health challenges. This session explores treatment challenges and options for a number of concurrent conditions that can compromise their health. 109 Sandra Gardener Viral Hepatitis Testing is Deficient in HIV Seropositive Patients: An OHTN Cohort Study Analysis 110 Geoffrey So Incidence of Hypertension in an Ontario HIV-positive Cohort 111 Darrell Tan Asymptomatic Shedding of Herpes Simplex Viruses (HSV) Despite Successful Antiretroviral Therapy in HIV-1, HSV Co-infection 112 Jill Tinmouth Perianal Bowen’s Disease in HIV-Infected Men Who Have Sex with Men Moderator Meaghan McLaren, University of Ottawa 12:30 pm Toronto I & II Lunch 1:00 pm Toronto I & II Focus on Intervention Research: CIHR Centre for REACH in HIV/AIDS Speaker: Sean B. Rourke, Ontario HIV Treatment Network, University of Toronto, St. Michael’s Hospital CIHR Centre in HIV Prevention Social Research Speaker: Liviana Calzavara, University of Toronto Finding New Solutions in HIV Prevention, Treatment and Support 11 Full Program Monday, November 16, 2009 1:30 pm Toronto I & II PLENARY: Prevention Interventions Beyond Our Borders What can we learn from prevention interventions used in other jurisdictions? Reducing Risk in Marginalized Populations: What can the North Learn from the South? Robert Carr, Associate Director of Policy and Advocacy, International Council of AIDS Service Organizations (ICASO) The issue of HIV prevention is a complex one that once seemed so straightforward but has proven to raise a number of challenges. The presentation will look at some of the key lessons learned in effective prevention work at the individual, group and community levels. Inter-relationships between these areas of intervention will be explored as well as some of the challenges that still need innovative solutions. Of particular interest will be the challenges of prevention in the context of concentrated and mixed epidemics and the role of stigma and human rights approaches in creating an environment in which progress on prevention becomes possible, including legal and political barriers, seen as symptoms of deeper, underlying issues that affect our responses to HIV. Lessons Learned from Dissemination of Evidence-Based Interventions for HIV Prevention in the United States Charles Collins, Team Leader, Science Application Team, Centers for Disease Control The US Centers for Disease Control and Prevention – Division of HIV/AIDS Prevention began disseminating evidence-based behavioral interventions to both community-based and clinic-based HIV prevention providers in 2002. Prior to this dissemination, it was estimated that 70% of all HIV prevention practice was street-outreach condom distribution. Over the last 7 years, 23 unique evidence-based interventions have been disseminated to over 3,388 HIV prevention agencies. The degree to which the field of prevention practice is willing to adopt evidence-based interventions is dependent on a range of factors including the complexity of the interventions selected for dissemination, the establishment of a customer centered philosophy that honors the prevention agency stakeholder’s ability to select, adopt, adapt, and implement the interventions; the costs of implementation; and the agency capacity to successfully implement the interventions. The lessons learned in the USA may be of benefit when considering strategies to increase the scientific basis for HIV prevention practice in Canada. Moderator Llana James, Incwell Consulting 12 RESEARCH AT THE FRONT LINES Full Program Monday, November 16, 2009 2:45 pm CONCURRENT SESSIONS Harris What Makes T-Cells Tick? Understanding Interleukin Regulation, Signaling and Stimulation Understanding how T-cells interact with the HIV virus is necessary to advance treatment options. This session will provide an overview of the most recent developments in interleukin research. 121 Angela Crawley Interleukin-4 Downregulates CD127 Expression on Human Thymocytes and Mature CD8+ T-cells 122 Elliott Faller JAK/STAT Signaling Mediates Regulation of IL-7R Expression on CD8 T Cells by Both Transcriptional and Non-Transcriptional Mechanisms 123 Alison O’Connor The Role of IL-7 in the Survival and Function of Memory CD8+ T Cells in Health and HIV Disease 124 Scott Sugden Mutational Analysis of the HIV Tat Protein and Its Ability to Down Regulate CD127 on CD8 T cells Moderator Paul MacPherson, Ottawa Hospital MacDonald HIV and Youth Arts-Based Approaches This session will explore how youth and researchers are using arts-based methods—theatre, collage, photovoice and hip hop—to make the links between structural inequalities and individual risk for HIV. It presents the world as a transformable place where youth can play active roles as change agents. Using this approach, youth are encouraged to critically research their worlds and supported in developing active strategies for change. Each presentation will describe the opportunities and challenges of using a particular arts-based method in the context of HIV prevention research and highlight what new results these novel approaches uncovered. Speakers Katie Cook, Wilfrid Laurier University Sarah Flicker, York University Alix Holtby, Wilfrid Laurier University Christine Smillie-Adjarkwa, Ontario Institute for Studies in Education Sarah Switzer, Educator and Consultant A creative arts-based project will be on display. It was created in partnership with youth and service providers from Evergreen Centre for Street Youth and Youthlink Inner City and academics from St. Michael’s Hospital and the University of Calgary to express experiences of street-involved young women with sexual health and pregnancy. Finding New Solutions in HIV Prevention, Treatment and Support 13 Full Program Monday, November 16, 2009 2:45 pm CONCURRENT SESSIONS Lismer Film Screening and Panel Discussion From Courage to Care: Living with HIV/HCV Co-Infection The premiere of the short film, From Courage to Care: Living with HIV/HCV Co-Infection documents the experience of three people with HIV and hepatitis C (HCV) co-infection. The film is one component of a larger web-based project that includes detailed modules on HIV/HCV treatment issues, stigma, harm reduction and rural access to care. A short Q&A session with the filmmaker and documentary subjects follows the screening. Speakers Michelle Latimer, Director, From Courage to Care: Living with HIV/HCV Co-Infection Colleen Price, Canadian Treatment Action Council Danny Williams, Prisoners HIV/AIDS Support Action Network Brenda LeSage, AIDS Thunder Bay Carmichael / Jackson Front Line Care: Improving Services for People With and At Risk for HIV This session examines aspects of the continuum of care for people with and at risk for HIV and includes surveys of personal patient and physician experiences, an assessment of provincial HIV/ HCV Co-Infection services and recommendations for national pregnancy guidelines. 117 Curtis Cooper HIV-HCV Co-Infection Service in Ontario: An Evaluation of Resources and Deficiencies 118 Shari Margolese A Multidisciplinary Approach to the Development of Canadian Evidence-based Guidelines on Safe Pregnancy Planning for HIV-Positive Individuals 119 Kevin Saya-Moore, Daryle Roberts The Engaging Physicians Project Assists General Practitioners in Creating a Non-judgmental and Welcoming Clinical Environment to Allow for the Safe Disclosure of Sexual Practices and Health Concerns of Men who have Sex with Men 120 Sandy Tecimer The Experiences of Ontario HIV-discordant Couples (Male Positive, Female Negative) in Seeking Sperm Washing Fertility Services Moderator Ken English, AIDS Bureau, Ministry of Health and Long-Term Care 14 RESEARCH AT THE FRONT LINES Full Program Monday, November 16, 2009 2:45 pm CONCURRENT SESSIONS Tom Thomson Reducing Risk in Gay Men and Other MSM Despite rising rates of HIV among other populations, gay men and other men who have sex with men continue to bear a disproportionate share of the epidemic. This session explores the risk factors for and the resilience of men who have sex with men. 113 David Brennan, Rory Crath Disordered Eating, Body Image and Sexual Risk among Gay and Bisexual Men 114 Jessica Cattaneo, Marco Posadas Towel Talk: A Brief Counselling Program For Men Using Bathhouses 115 Todd Coleman, Daniel Pugh Qualitative Findings from the Health in Middlesex Men Matters (HiMMM) Project 116 Devan Nambiar, Andre Ceranto Developing a Coordinated Research Agenda for Ethnoracial Men who have Sex with Men in Ontario Moderator James Murray, AIDS Bureau, Ministry of Health and Long-Term Care Toronto I & II DEBIs In-Depth Charles B. Collins Jr., PhD, National Center for HIV, STD and TB Prevention, the Centers for Disease Control and Prevention Charles B. Collins provides an in-depth look at the Diffusion of Effective Behavioural Interventions (DEBI) program in the United States and the core principles to consider when adapting DEBIs to a local context. The DEBIs are designed to bring science-based, community, group, and individuallevel HIV prevention interventions to community-based service providers. Their goal is to implement effective interventions, reduce the spread of HIV, and to promote healthy behaviors. Finding New Solutions in HIV Prevention, Treatment and Support 15 Full Program Monday, November 16, 2009 4:00 pm Toronto I & II Dr. Susan King Lecture Focus on Youth: Taking a DEBI from Baltimore to the Bahamas Bonita Stanton, Children’s Hospital of Michigan Lynette Deveaux, Focus on Youth, Bahamas Ministries of Health and Education Focus on Youth in the Caribbean, a 10-session HIV prevention program targeting grade sixth youth, was developed, implemented and evaluated by a team of investigators from the United States and the Bahamas. Two programs were also developed for their parents: Caribbean Informed Parents and Children Together is a 22-minute video emphasizing the importance of parent-child communication about sexuality followed by structured role-play and condom practice; and, Goal for It is a 22 minute video emphasizing the importance of planning ahead and is followed by supervised discussion and answers. The US-Bahamian team evaluated these interventions through a randomized, controlled three-celled longitudinal trial (36 months follow-up) involving 15 elementary schools in The Bahamas. Significant program effect was detected including increases in coping appraisal; enhancement of HIV/AIDS knowledge, condom-use skills, intention to use condom; and increases in condom-use. Moderator Stanley Read, Hospital for Sick Children 4:45 pm Toronto I & II Prevention Interventions Within Our Borders There is an urgent need for innovative prevention programs to reduce the number of people newly diagnosed with HIV each year in Ontario from 1,000 to nil. This session features innovative examples of prevention intervention programs in Ontario. Having Sex while Drunk or High: Do Men who have Sex with Men Want to Change? Timothy Guimond, Rainbow Services, Centre for Addiction and Mental Health Re-envisioning the Wheel: Adapting Many Men, Many Voices to Ontario David Lewis-Peart, Black Coalition for AIDS Prevention Operation Hairspray 2: Spray The Word About Health – An African and Caribbean Community Partnership Zhaida Uddin, Ottawa Public Health & Suzanne O’Byrne, Somerset West Community Health Centre Mano en Mano Gerardo Betancourt, Centre for Spanish Speaking People Evaluation of the HIV Stigma Campaign James Murray, AIDS Bureau Moderator Barry Adam, University of Windsor, Ontario HIV Treatment Network 16 RESEARCH AT THE FRONT LINES Full Program Monday, November 16, 2009 6:00 pm Lismer HIV Epidemic in Ukraine – Challenges and Opportunities Ukraine has the most severe HIV epidemic in Europe with an estimated 400,000 people living with HIV, but only 20% are diagnosed. A new National AIDS Program was developed to scale up accessible prevention, care, treatment and support. Members of the team leading the Ukrainian initiative will discuss the scale-up’s challenges and opportunities. HIV in Ukraine – The Current Situation and National AIDS Strategy Olena Ieshchenko, Deputy Head, National AIDS Committee, Ukraine Ministry of Health The Role of Community-based Field and Outreach Services in HIV Prevention and Support Viktor Isakov, Program Director, Outreach and Field Services, International HIV/AIDS Alliance Ukraine HIV in Ukraine – Capacity Development Challenges and Opportunities Yuri Kobyshcha, HIV/AIDS Officer, World Health Organization, Ukraine Moderators Carol Major, Ontario HIV Treatment Network Frank McGee, Ontario Ministry of Health and Long-Term Care 6:00 pm Tom Thomson Innovations for People with HIV/AIDS 6:00 - 8:00 pm Foyer Reception Introducing initiatives specifically designed for PHAs: including the launch of the PHA Learning Partnership, the announcement of the Legacy Mentorship Project, how to locate an HIV Related Service using ASO411, CATIE initiatives in e-learning and online ordering of resources, and a variety of initiatives from the Ontario AIDS Network. Finding New Solutions in HIV Prevention, Treatment and Support 17 Full Program Tuesday, November 17, 2009 8:00 am Foyer Registration and Breakfast 8:30 am Toronto I & II PLENARY: Cellular Interventions and Clinical Care HIV Vaccine Discovery: Lessons from Steven Spielberg Mario Ostrowski, University of Toronto HIV has devised multiple strategies to evade and disarm the human immune response that is trying to control the virus, behaving like a trojan horse in tricking the immune system. Thus, there is no clearly effective vaccine to prevent HIV infection; nor can the infection be completely eradicated. These conditions have discouraged scientists, but have also allowed some to take drastic if not unusual approaches that do not fit current paradigms of vaccine development. With the help of Steven Spielberg, this presentation will describe one strange approach that our laboratory has embarked upon. Rebuilding Health: One T-Cell at a Time Juan Carlos Zúñiga-Pflücker, University of Toronto T cells develop within the thymus, and their differentiation involves a series of commitment events and developmental checkpoints including T-lineage commitment, T cell receptor (TCR) gene recombination and positive/negative selection to yield functionally mature T cells. These events occur in a sequential, temporal and spatial fashion, as developing thymocytes migrate through the thymus. His laboratory has developed a simple approach that makes use of a bone marrow stromal cell line (OP9) expressing the Notch receptor ligand Delta-like 1 (OP9-DL1) that effectively replicates the key functions of the thymus, by inducing and supporting the generation of large numbers of human progenitor T cells from hematopoietic stem cells in vitro. This cell culture system has several important advantages for the generation and study of human T cell development. In particular, emphasis on how in vitro-generated progenitor T cells can be used to regenerate T cell function in animal models. Their potential implications for the treatment of immune-related diseases such as HIV-induced immunodeficiency will be discussed. 18 RESEARCH AT THE FRONT LINES Full Program Tuesday, November 17, 2009 8:30 am Toronto I & II PLENARY: Cellular Interventions and Clinical Care Co-infections and Co-morbidities: Meeting the Challenges of a Maturing Epidemic Marina B. Klein, McGill University Health Centre Since the advent of effective combination antiretroviral therapy, there have been dramatic reductions of morbidity and mortality among people with HIV. Non-AIDS related illnesses, co-infections and co-morbidities that were once rare, such as chronic viral hepatitis, human papilloma virus, cardiovascular disease and neurocognitive dysfunction, have emerged as important causes of illness and death among HIV infected persons. Furthermore, the HIV-infected population is aging and living with long-term exposure to antiretrovirals, both of which may modify the risk for disease and complicate its management. This presentation will review the current understanding of non-AIDS related conditions and co-morbidities and highlight the challenges that HIV-infected persons and their caregivers face in understanding and managing these conditions with a focus on future directions for research and intervention work. Moderator Maggie Atkinson, AIDS ACTION NOW! CONCURRENT SESSIONS 10:30 am Foyer Poster Viewing 10:30 am Carmichael / Jackson HIV, Housing and Health: The Positive Spaces Healthy Places Study This session will present findings from the first longitudinal community-based research initiative in Canada to examine the relationship between HIV/AIDS, housing instability and homelessness, and quality of life. The intersecting and compounding factors which place people with HIV from specific sub-populations at increased risk will be examined. This study provides compelling evidence of the need for targeted policy and programming strategies that recognize the unique housing-related needs of people with HIV from specific sub-populations in order to maximize community-level impact. Worsening of Social Determinants of Health Among Aboriginal People Living with HIV/AIDS The Need for Stable and Affordable Housing Among Women Living with HIV in Ontario Disadvantages of Social Determinants of Health Among African or Caribbean Persons Living with HIV in Ontario Persisting Disparities of Social Determinants of Health Between Aboriginal and Caucasian Persons Living with HIV Speakers Positive Spaces Healthy Places Study Team Finding New Solutions in HIV Prevention, Treatment and Support 19 Full Program Tuesday, November 17, 2009 CONCURRENT SESSIONS 10:30 am Toronto I & II Enduring Partnerships: Focus on Youth in the Caribbean Bonita Stanton, Children’s Hospital of Michigan Lynette Deveaux, Focus on Youth, Bahamas, Ministries of Health and Education Beginning in the early 1990’s, an interdisciplinary group, including pediatricians, anthropologists, health educators, psychologists and statisticians, developed and evaluated an HIV prevention intervention targeting early adolescents living in public housing developments in Baltimore, Maryland. The intervention, Focus on Kids, was effective in reducing risk behaviors and was included in the CDC’s portfolio of effective adolescent programs. Learning about Focus on Kids and concerned about their own growing problem with HIV, the Ministries of Health and of Education of the Bahamas approached the researchers about collaborating to develop a similar program. A partnership developed which has spanned over a decade and ultimately led to the development of an intervention program targeting Bahamian children in grade six, a 10-session adolescent HIV prevention program, and two programs targeting parents. This talk will describe the context in which the epidemic occurred, events leading up to the collaboration and the factors that have allowed it to succeed. 10:30 am Tom Thomson If You Were Rejected Every Time You Disclosed, Would You? Lessons Learned from the HIV Stigma Campaign Barry Adam, University of Windsor, James Murray, AIDS Bureau This session assesses the lessons learned from the largest HIV-related work campaign directed towards gay and bisexual men in Ontario. The campaign sought improve sexual health by addressing stigma in the environment where gay and bisexual men have sex. 10:30 am MacDonald Web Tours 11:00 am Lismer Film Screening Get an inside look at the resources available on the Canadian Institutes of Health Research, Canadian AIDS Treatment Information Exchange, Healthy Housing, and Ontario HIV Treatment Network websites. FIX: The Story of an Addicted City This documentary captures the pulse of one of Canada’s most controversial issues. It is the story of Vancouver’s struggle to open Canada’s first safe injection site for drug users. It is the story of a man and of a city fighting drugs and addiction. Dean Wilson used to be an IBM salesman. Now he is possibly the most outspoken drug addict in Canada. He is a loud and articulate advocate for street addicts from Vancouver’s Downtown Eastside, one of Canada’s poorest neighbourhoods, and the site of the highest HIV rate in North America. Ann Livingston is the charismatic organizer of VANDU, the Vancouver Area Network of Drug Users. She is a nonuser, driven by an impatient spirituality. Together Ann and Dean lead an unpredictable crew of street addicts in their fight to open North America’s first safe injection site in Vancouver. 20 RESEARCH AT THE FRONT LINES Full Program Tuesday, November 17, 2009 11:30 am CONCURRENT SESSIONS Harris Reaching High Risk Youth in Smaller Urban Centres This session features innovative youth outreach programs in Ottawa, Hamilton and Kingston. 137 Matthew Allen, Maiya Forrest Jazmyn Hallman How Can Youth have Meaningful Engagement in Community-based Research? The Safe n’ Sexy Project Experience 138 Sandra Bullock Predictors of HIV Testing Among Street-involved and Homeless Youth in Hamilton, Ontario: The Safe n’ Sexy Project Results 139 Ron Shore High-risk Youth, Drug Use and Hepatitis C in Kingston, Ontario 140 Zhaida Uddin Did You Spot the Banana? An Evaluation of a Sexually Transmitted Infection Campaign for Ottawa Youth Moderator Cathy Worthington, University of Calgary MacDonald Outsmarting the Virus: Factors that Inhibit and Stimulate Viral Replication This session explores a variety of factors that activate or inhibit replication of HIV-infected cells in search of strategies to intercept this process. 133 Alan Cochrane Composition of HIV-1 RNP Confers Differential Regulation of Viral Gene Expression 134 Wendy Dobson-Belaire HIV-1 and Gonorrhea Co-infection: A Disconnect Between Responses in Cell Lines and Primary Cells 135 Rebecca Malott Effect of a Novel, Neisseria-specific Immune-Stimulatory Factor on HIV-1 Expression and Lymphocyte Activation 136 Raymond Wong Clk SR Protein Kinases and Drugs Modulating Alternative Splicing Demonstrate Potent Inhibition of HIV-1 Viral Replication Moderator Rupert Kaul, University of Toronto, University Health Network Finding New Solutions in HIV Prevention, Treatment and Support 21 Full Program Tuesday, November 17, 2009 CONCURRENT SESSIONS 11:30 am Carmichael / Jackson One Size Does Not Fit All: Tailoring Programs to Meet the Needs of Women and HIV Gender has a dramatic impact on the factors that put women at risk for HIV and the services available to HIV-positive women. This session explores women’s diverse experiences and needs. 125 Edna Aryee Providing Affordable Housing and Improving the Quality of Life of AfricanCanadian Women Living with HIV/AIDS in Ontario 126 Alexandra Borwein You’re Breaking My HAART: HIV and Violence Among a Cohort of Women on Antiretroviral Therapy in British Columbia, Canada 127 Lori Chambers, Khatundi-Irene Masinde A House is Not a Home: The Impact of Gender, Race and Stigma on the Housing Experiences of African and Caribbean Mothers Living with HIV 128 Tracey Prentice HIV Prevention and Women in Canada: A Meta-Ethnographic Synthesis of Current Knowledge 173 Uitsile Ndlovu Mandatory Prenatal HIV Testing and the Opt-in vs Opt-out Debate: African/Caribbean Women Diagnosed with HIV During Pregnancy Weigh In Moderator Lisungu Chieza, Women’s Health in Women’s Hands 11:30 am Tom Thomson Trials and Tribulations of HAART Highly active antiretroviral therapy has resulted in dramatic improvements in health, but is also associated with many adverse events. This session examines the effects of adherence, lipodystrophy, gastrointestinal problems, and potential genetic ramifications of HAART. 129 Nisha Andany Gender and Ethnicity Differences in Body Change and Distress of HIVPositive Individuals Taking Antiretroviral Therapy in Ontario 130 Prameet Sheth Impact of Long-Term Highly Active Antiretroviral Therapy (ART) on CD4+ T Regulatory and TH17 Cells in the Blood and Sigmoid Colon 131 Charles la Porte The Effect of Multiple Dose Lopinavir/Ritonavir on Intestinal mRNA Expression of ABCB1, ABCC1, ABCC2, CYP2B6, CYP3A4, SLCO1B1, CAR, FXR, PXR and RXR in Healthy Volunteers 132 Janet Raboud Predictors of Adherence among HIV-Positive Individuals on HAART Therapy Moderator Jonathan Angel, Ottawa Health Research Institute, Ottawa Hospital 12:30 pm Toronto I & II 22 Lunch RESEARCH AT THE FRONT LINES Full Program Tuesday, November 17, 2009 1:00 pm Toronto I & II Poster Awards, Jay Browne Living Legacy Award 1:30 pm Toronto I & II PLENARY: How Research Can Drive Change Researcher as Advocate Thomas Kerr, BC Centre for Excellence in HIV/AIDS, University of British Columbia A growing frustration with the irrelevance of conventional research has prompted a renewed focus on scientists becoming more engaged with the broader community and the policy development process. Traditional models of knowledge translation and transfer of research often have little relevance or influence in the HIV/AIDS realm – especially those instances where ideology and dominant cultural norms trump scientific evidence. Drawing on personal experiences researching and advocating for harm reduction and HIV prevention programs in Canada and Thailand, Dr. Kerr will explore the tensions that can arise when researchers seek to promote change by advocating with their research and shed light on the various actors and activities that are central to ensuring that research leads to action and evidence-based decision-making. Dr. Kerr will also explore the role researchers can play in instances where traditional forms of knowledge translation and transfer are likely to have little impact. 2:00 pm Dr. Charles Roy Lecture Involved, Invested and Inspired: Shared Leadership and Collective Empowerment in the Third Space of Research-Policy-Practice Alan Li, Regent Park Community Health Centre and OHTN CBR Fellow GIPA (Greater Involvement of People Living with HIV/AIDS), a grassroots movement that began in the early 1980s and was formalized at the 1994 Paris AIDS Summit, has created a “third” space whereby PHAs, service providers, policy-makers and researchers gather to find solutions to the physical, social, political, economic and spiritual impact of HIV on individuals and communities affected. Advances in HIV treatment, globalization and societal changes have given rise to the changing contexts of HIV/AIDS and GIPA. The third space, rooted in critical postcolonial and race theories, refers to the dynamic space between the centre and the margins where the historically oppressed or socially excluded communities dialogue, interact and develop new thinking, hybrid cultures and innovative practices that challenge the status quo and the dominant discourse. This lecture addresses the needs to re-conceptualize GIPA and challenge the conventional research and knowledge translation and exchange (KTE) paradigms. It highlights the potential in the third space for research and KTE cross-fertilization, PHA capacity building, and collective empowerment to achieve health equity. Moderator Evan Collins Finding New Solutions in HIV Prevention, Treatment and Support 23 Full Program Tuesday, November 17, 2009 2:45 pm CONCURRENT SESSIONS Harris For Mature Audiences Only: Sexual Risk Taking in Adults 45+ Little is known about HIV risk behaviour among older adults and the impact of aging with the virus. This session surveys the landscape of people aging with HIV and examines the treatment and prevention needs for a diverse group of older adults. 153 Shelley Craig The Importance of Provider Endorsement to Voluntary HIV Counseling and Testing for Older Minority Women 154 Charles Furlotte Health and Social Service Experiences of Older Adults Living with HIV/ AIDS in the National Capital Region 155 Judy Gould HIV and Aging – An Emerging Landscape for Consideration and Care 156 Katie Mairs Sexual Risk Behaviour Among Canadian Snowbirds who Winter in Florida: Who is HIV Testing? Moderator Yvette Perrault, AIDS Bereavement Project MacDonald The Fight for Immunity: Advances in Vaccine and Immune Responses Recent media attention has renewed public interest in the development of an HIV vaccine. Researchers will present findings from local vaccine and immunity initiatives that are contributing to the global effort. 149 Ali Azizi Maturation of Dendritic cells by Liposomal-delivery of Multivalent HIV Antigens 150 Anna Drannik Trappin-2/Elafin is Associated with Antiviral Activity and Reduced Production of Pro-Inflammatory Factors in Human Genital Epithelial Cells 151 Sumiti Jain Targeting gp41 as a Strategy to Induce Mucosal Humoral Immunity Against HIV-1 152 Brad Jones Comprehensive Elimination of Globally Diverse HIV Primary Isolate Infections by HERV-K-Specific CD8+ T Cells Moderator Dan Allman, The University of Edinburgh Centre of Canadian Studies 24 RESEARCH AT THE FRONT LINES Full Program Tuesday, November 17, 2009 2:45 pm CONCURRENT SESSIONS Lismer Critical Social Science and Humanities Research at the Front Lines: Intervening in Theory, Methods and Practice This year’s OHTN Conference theme focuses on research conducted at the “front lines” with a particular interest in research that can contribute to new interventions in HIV treatment, care and support. What role do the critical social sciences and humanities play in front line intervention research? In what ways can the theories, methods and research perspectives of the critical social sciences and humanities contribute to improvements in HIV treatment, care and support? In what ways might they challenge or unsettle assumptions about the form that “intervention research takes”? The papers in this session will address these and related questions through a range of approaches. Disclosure Work: Trans Youth Negotiating Relationships, Sexuality and Safety in a Cisnormative Social World Rebecca Hammond, Dalhousie University, Hassle Free Clinic Uncensoring Stigma: Research and Response-ability Rosemary Jolly, Queens University Reading Decolonizing Methodologies: Towards an Aboriginal HIV/AIDS Research Approach Randy Jackson, Canadian Aboriginal AIDS Network, McMaster University Moderators Eric Myhkalovskiy, York University Barry Adam, Ontario HIV Treatment Network, University of Windsor Carmichael / Jackson Where There’s Smoke: Results from Recent Safe Inhalation Studies Research has shown that safe injection sites provide a valuable harm reduction service. Can a similar approach work for reducing risk for people who smoke crack? 145 Jennifer Jairam Toronto Drug Users Willingness to Use a Supervised Consumption Site and Their Preferred Service Models 146 Pamela Leece The Effectiveness of Harm Reduction Programs to Prevent HIV and HCV Transmission Among People who Smoke Crack: A Systematic Review of the Evidence 1990-2008 147 Peggy Millson Where Do Injection Drug Use and Crack Smoking Occur in Toronto? 148 Tara Marie Watson A Place to Smoke Too: Identifying Challenges for the Design of Supervised Consumption Sites (SCSs) for Crack Smokers Moderator Paul Lavigne, Ottawa Public Health Finding New Solutions in HIV Prevention, Treatment and Support 25 Full Program Tuesday, November 17, 2009 2:45 pm CONCURRENT SESSIONS Tom Thomson Cultural Insights: Closing Gaps in Research, Prevention and Care Cultural communities have distinct needs for HIV prevention, treatment and support services. This session examines the gaps in research, policy and practice for culturally diverse communities in Ontario. 141 Firdaus Ali Stigma and Discrimination among Canadians of South Asian Descent in Toronto 142 LLana James, Mrya Romyen, Wangari Tharao The Way Forward: African, Caribbean and Black Canadian HIV/AIDS Research Think Tank 143 Noulmook Sutdhibhasilp Migrant Farm Workers in Ontario: Health and HIV 144 Y. Rachel Zhou Living in “Transnational Spaces”: An Exploration of the Influence of the Home Country on the HIV Risk Facing Recent Chinese Immigrants in Canada Moderator Josephine Wong, Ryerson University 4:00 pm CONCURRENT SESSIONS Harris On the International Front: Local Researchers, Global Impact Ontario researchers are studying prevention efforts in China, intervention programs in Cambodia, MSM epidemiology in Nigeria and the integration of the HIV and disability sectors worldwide to better understand risk factors and responses to the global pandemic. 165 Liviana Calzavara Understanding the Epidemic and Strengthening Prevention Efforts in China: Condoms Use and Knowledge among Migrants in Shanghai 166 Ian Lubek, Michelle Green, Kate O’Brien Canadian Students Following Up on an HIV/AIDS “Primary Intervention” Program in Cambodia (2006-2009) 167 Ted Myers HIV, Sexually Transmitted Infections and Men who have Sex with Men (MSM) in Sub-Saharan Africa - The Case of Nigeria 168 Stephanie Nixon HIV and Disability in a Global Context: Into the Spotlight At Last Moderator Darryl Perry, Ontario HIV Treatment Network Board Member 26 RESEARCH AT THE FRONT LINES Full Program Tuesday, November 17, 2009 4:00 pm CONCURRENT SESSIONS MacDonald What a Teen Wants, What a Teen Needs – Improved Sex Ed and Health Services for Youth Teens want to know more about sex. They need to know how to protect themselves and their partners. This session explores what teens know, how they behave, and what services they need. 169 Helena Shimeles Unpack the Black: Exploring Black Youth Sexual Behaviours in the TDOT 170 Helena Shimeles Unpack the Black: Exploring Access to Clinical Sexual Health Services for Black Youth in the TDOT 171 Susan Flynn, Robb Travers Why do Toronto Youth Learn So Much and Yet Not Know So Much About HIV/AIDS? Results and Recommendations from the Toronto Teen Survey 172 Denise Jaworsky Involving Youth in Determining Evaluation Needs for Youth Sexual Health Peer Education Programs Moderator Angel Parks, AIDS Committee of Toronto Lismer Innovative PHA Skill Building Strategies This session will showcases several innovative strategies and tools that support and facilitate PHA capacity building in various areas including research and community engagement. PHAlearning.org: A Tool to Coordinate and Accredit Community Capacity Building Joan Anderson, Toronto HIV/AIDS Network Mark Fisher, Ontario HIV Treatment Network Emmanuel Ndyanabo, Committee for Accessible AIDS Treatment “Can We Talk”: a Multi-Sectoral Collaborative Innovative Training Program to Facilitate Empowered PHA / Health Provider Communication Maureen Owino, Committee for Accessible AIDS Treatment Judy Daniels, Tibotec, a division of Janssen-Ortho Coming Out in Research: Training to Address Stigma and Disclosure Challenges of PHA Researchers Working Within their Own Ethno-Racial Communities Henry Luyombya, Committee for Accessible AIDS Treatment Andrew Miao, Committee for Accessible AIDS Treatment Marisol Desbiens, Committee for Accessible AIDS Treatment Community Engagement Strategy to Involve Ethno-Racial, Faith-Based, Media and Social Justice Leaders to Address HIV Stigma and Discrimination Josephine Wong, Ryerson University Henry Luyombya, Committee for Accessible AIDS Treatment Omer Abdulghani, Committee for Accessible AIDS Treatment Finding New Solutions in HIV Prevention, Treatment and Support 27 Full Program Tuesday, November 17, 2009 4:00 pm CONCURRENT SESSIONS Carmichael/ Jackson Knowing What Works: Using Data to Drive Services in HIV Prevention and Care This session provides examples of innovative program monitoring and evaluation systems that use data to drive developments in service and policy. 157 Rob Boyd, Catherine Vandelinde Implementing an Anonymous Code in a Needle Exchange/Safer Inhalation Program: What We Have Learned 158 Nicole Greenspan Public Health, Condoms and Bathhouses: A Cost-effectiveness Analysis of Providing Condoms to Reduce the Spread of Syphilis at Bathhouses in Toronto 159 Duncan MacLachlan Capturing Conversations: Implementing a Comprehensive Service Reporting System for MSM Bathhouse Outreach 160 Nadia O’Brien Predictors of Emergency Department use by Individuals on HAART Moderator Murray Jose, Toronto PWA Foundation Tom Thomson A Dose of Reality: Innovative IDU Strategies More than 10% of people with HIV in Ontario may have been exposed to the virus through injection drug use. These innovative studies investigate the roles initiation, supervised injection facilities and prisons play in reducing the potential harms associated with IDU. 161 Sandra Ka Hon Chu Injecting Realities: Effective Advocacy for HIV Prevention in Canadian Prisons 162 Gillian Kolla Exploring the Context of Injecting for the First Time – A Qualitative Study 163 Kate Smith If We Build It, Would They Come? The Feasibility of a Supervised Injection Facility in Ottawa 164 Carol Strike Giving Someone Their First Hit – Implications for HIV Prevention Programming Moderator Richard Elliott, Canadian HIV/AIDS Legal Network 28 RESEARCH AT THE FRONT LINES Exhibition and Cover Art Cover Art This year’s cover art is a transparent glass sculptural replica of the HIV virus created by Luke Jerram. Part of a series of glass microbiology sculptures, Jerram’s work strives to contemplate the global impact of diseases and the ways that artificial colouring in scientific imagery affects understanding of the phenomena. Removing this colouring changes the ways we perceive the representations of the disease. He is exploring the tension between the artworks’ beauty and what they represent, their impact on humanity. Virologists at the University of Bristol provided consultation on the creation of this work using a combination of different scientific photographs and models. Editions of the HIV sculpture are on display in the Wellcome Collection, London and the Bristol City Museum. The following is an anonymous letter sent to Jerram about his work: Dear Luke, I just saw a photo of your glass sculpture of HIV. I can’t stop looking at it, knowing that millions of those guys are in me, and will be a part of me for the rest of my life. Your sculpture, even as a photo, has made HIV much more real for me than any photo or illustration I’ve ever seen. It’s a very odd feeling seeing my enemy, and the eventual cause of my death and finding it so beautiful. Thank you www.lukejerram.com Casson The Power of One- Visualizing HIV Epidemiology Understanding epidemiology can give even the most experienced statistician some trouble, but with this exhibit, CATIE is hoping that a simple grain of rice will help. Based on ideas used by Stan’s Café, a UK theatre company, the Power of One exhibit uses grains of rice to give a graphic presence to numbers which illustrate the HIV epidemic in Canada. Each grain of rice represents one person – when you enter the space, you are given a single grain to represent yourself. The statistics, presented as labeled, differently-sized piles of rice, will invite viewers to draw conclusions that can be moving, shocking, and thought-provoking. Juxtaposing Canadian HIV epidemiological numbers with other facts and statistics that may be surprising and even funny, reminds viewers of the humanity and humour required to understand the landscape of HIV. We aim to assist viewers and participants to better understand basic epidemiological information about HIV in Canada and in their region by creating representations of various HIV-related statistics. In needs assessments and consultations throughout Canada, 79% of front line organizations working in HIV indicated the need for tools to assist them to use and interpret epidemiological information. This innovative, thought-provoking and interactive exhibit translates and simplifies this information using plain language and accessible examples to assist people to understand the epidemiology of HIV in Canada. Finding New Solutions in HIV Prevention, Treatment and Support 29 Biographies Barry D Adam, PhD Barry D Adam is University Professor of Sociology at the University of Windsor, and Senior Scientist and Director of Prevention Research at the OHTN with a mandate to draw together researchers, policy-makers, and community-based organizations in building province-wide capacity in effective interventions for HIV prevention. Barry comes to HIV work with an extensive research record on the dynamics of domination and empowerment, LGBT studies, HIV prevention, and issues of living with HIV. He is currently investigating (a) how social discourses of masculinity, autonomy, adventurism, and romance influence safer-sex decision-making; (b) the development of an attractive and effective HIV prevention and sexual health program for HIV-positive men; (c) creation of an intervention for Latino newcomers to Canada to help address their elevated rate of HIV sero-conversion; and (d) impacts of criminal prosecutions for HIV exposure and transmission on people living with HIV. Jonathan Anderson, PhD Jonathan Anderson studied medicine at Bristol University, UK and trained as a general practitioner. After moving to Melbourne Australia in 1990, he worked in a busy primary care clinic with a special focus on gay and lesbian health, HIV, and sexual health. He has extensive experience in clinical and public health research: his current research portfolio includes studies of the cost-effectiveness of interventions for the prevention and management of HIV and their role in informing decision-making, as well as studies measuring the quality of life and cost of care in HIV. He is currently Senior Research Fellow with Deakin University Health Economics, a research fellow with the Australian National Centre in HIV Epidemiology and Clinical Research and in 2008 was awarded the title of Adjunct Associate Professor by Sydney Medical School. For the past two years, he has been the President of the Australasian Society for HIV Medicine, the peak body for people working in HIV. He is a former member of the Australian National Ministerial Advisory Committees on HIV and a current member of Victorian Ministerial Advisory Committee on Hepatitis. He has also been the chair of the Biomedical Prevention working group of the Australian National Centre in HIV Epidemiology and Clinical Research. Gerardo Betancourt Gerardo Betancourt was born in Mexico, where he worked as a high school teacher for five years. Holding degrees in Law and Education, he immigrated to Canada in 2000 and started the process of assimilation and integration. In 2006, he started working as a Men’s Outreach Worker at the HIV Prevention Program at the Centre for Spanish-Speaking Peoples (CSSP). In 2007, he began the Masters in Adult Education and Community Development program at the Ontario Institute for Studies in Education at the University of Toronto. He has participated for two years in the Summer Learning Institute program at the OHTN. He has presented posters and oral presentations at conferences, both domestic and international, and in 2008 he presented the first national Latino HIV/HEP C campaign in Canada: ‘Guys Like You’ (www.guyslikeyou.ca). He has also worked with Barry Adam on community based research projects and is co-principal investigator for ‘Mano en Mano’. He is currently preparing a CBR study of Latino and Portuguese Vulnerabilities ‘Cuentame’, also with Barry Adam. He is currently AIDS Community Educator at CSSP. 30 RESEARCH AT THE FRONT LINES Biographies Jay Browne, PhD Jay Browne received his Masters in Social Work from Ohio State University and a PhD in interdisciplinary studies (sociology, community health, applied psychology and adult education) from the University of Toronto (OISE). Jay was Director of Social Work at Chedoke-McMaster Hospitals and held a faculty appointment in the Department of Psychiatry at McMaster University as an Associate Professor. As the Chair of the Ontario Public Education Panel on AIDS, Jay was instrumental in helping the Ontario government launch a very successful prevention/education campaign. Jay was a member of the Ontario AIDS Advisory Committee and Coordinator of AIDS programs for Ontario. An inspirational force in the creation of the OHTN, Jay briefly served as the OHTN’s interim Executive Director. He is well known for his kindness and compassion and has a great deal of respect for people with HIV and encourages them to speak out on their own behalf. Liviana Calzavara, PhD Liviana Calzavara a Professor at the University of Toronto and Deputy-Director of the Social, Behavioural and Epidemiological Studies Unit, which specializes in education and research related to the social and behavioural aspects of HIV/AIDS among marginalized populations. She is also the Director of the CIHR Centre in HIV Prevention Social Research located at the Dalla Lana School of Public Health. Liviana’s research integrates epidemiological and social science disciplines to provide a better understanding of HIV transmission and prevention. Robert Carr, PhD Dr Robert Carr is Associate Director of Policy and Advocacy at the International Coalition of AIDS Services Organisations (ICASO). He has been active in the field of HIV since 2000, when he began research and advocacy on stigma and discrimination against people living with HIV in Jamaica, and then in 2002, became Executive Director of Jamaica AIDS Support for Life, a national NGO serving the most disenfranchised in Jamaican society, including prisoners, the hearing impaired, sex workers, gay men and other men who have sex with men. Dr Carr went on to co-found the Caribbean Vulnerable Communities Coalition, a coalition of indigenous frontline service providers working on rights based programming with marginalised groups across the Caribbean. He has also published several books, including, Sexuality, Social Exclusion and Human Rights: Vulnerability in the Caribbean Context of HIV (Ian Randle Press, 2009), co-edited with Christine Barrow and Marjan de Bruin, both of the University of the West Indies. Lisungu Chieza They say that you are someone through someone. I am who I am today because someone shared their story. A micro-biologist and counselor by profession, Lisungu has lived openly with HIV for more than a decade. During this time she has worked passionately to ensure the rights of women and girls living with HIV/AIDS in Zimbabwe, Africa and more recently for African and Caribbean women living in Toronto. She currently works for Women’s Health in Women’s Hands (WHIWH) as the Clinical Research Coordinator for the CIHR Emerging team in HIV and Co-Infections study. Through her involvement and personal achievements she works to empower others to live positively with HIV/AIDS and also ensures that the capacity of PLWHA is enhanced so that PLWHA are not just consumers of services but become providers of service as well. She is a proud mother of two teenagers Taku and Tapi. Finding New Solutions in HIV Prevention, Treatment and Support 31 Biographies Charles Collins, PhD Charles B Collins, Jr. Ph.D. is the Section Chief for Science Application in the Division of HIV/AIDS Prevention at the CDC. His team of scientists are responsible for the dissemination of evidence based behavioral interventions into HIV prevention practice. They are working with 25 evidence-based interventions designated as having the highest evidence of efficacy. He has designed, implemented, and evaluated an HIV intervention for African American drug users and a multi-site community-level intervention for young MSM of color. He has conducted evaluability assessments and evaluations in community-based organizations. Dr. Collins has published in many journals including AIDS Education and Prevention, AIDS Care, and The Journal of Public Health Management and Practice,. Dr. Collins received his Ph.D. from the University of Alabama at Birmingham School of Public Health. He received the National Center for HIV, Hepatitis, STD, and Tuberculosis Prevention Award for Operational Research in 2002 and the Director’s Recognition Award in 2008 for his work on the Tiers of Evidence. Marisol Desbien Marisol Desbiens is a volunteer, public speaker and a peer research assistant. Her involvement with HIV/AIDS started two years ago when she joined Voices of Positive Women. She is a volunteer for the Speakers Bureau at PWA. She currently is the President for Latinos Positivos Ontario. Marisol is actively involved in the HIV community. She works with Positive Spaces Healthy Places (PSHP) and Committee for Accessible AIDS Treatment (CAAT) doing community-based research projects. Lynette Deveaux Lynette Deveaux is the Project Coordinator/Investigator for the Focus on Youth Research Programme, an HIV and Teen Pregnancy Prevention Initiative. This research is in collaboration with Ministries of Health and Education in The Bahamas as well as Wayne State University, Detroit, Michigan. A School Psychologist, Mrs. Deveaux is presently on secondment from the Ministry of Education where she functioned as the clinic and administrative Supervisor for the School Psychological Services Unit in the Special Services Section. Her responsibilities included working with marginalized and at-risk youths and their families. Mrs. Deveaux assisted in the adaptation of ‘Focus on Kids’ curriculum to the more culturally appropriate ‘Focus on Youth’ curriculum. A specialist in training of trainers, she places much emphasis on a practical interactive approach to training, allowing people to participate in formal ‘Teach-Backs,’ which are essential for effective implementation of new programs. She presently co-chairs the HIV and AIDS Education Sector Policy Committee. Tim Guimond Dr. Tim Guimond is a Clinician-Researcher in Rainbow Services of the Addictions Program of the Centre for Addiction and Mental Health. In addition to providing clinical services to Rainbow Services, he also teaches students in the Addictions Program and conducts research with the LGBTT community. Tim has substantial community based expertise, having founded the Ontario wide Lesbian Gay Bi Youth Line as well as the Baltimore-Washington Dancesafe project, and consultation to the Gay Men’s Crystal Meth Task Force. Tim’s educational background includes medical school at the Johns Hopkins University, a psychiatric residency at the University of Toronto, where he also completed a Masters of Science in Statistics. Tim completed the last two years of his residency at CAMH where he was involved in the concurrent disorder service, provided statistical analysis to Dr. McMain’s HOPE study on DBT versus general psychiatric management. 32 RESEARCH AT THE FRONT LINES Biographies Randy Jackson, PhD cand. Randy Jackson is currently completing his PhD at McMaster University in the faculty of Social Work. Randy is also the Director of Research and Programs with the Canadian Aboriginal AIDS Network (CAAN) and a recent OHTN Community Scholar. Originally from the Chippewas of Kettle and Stoney Point First Nation (southwestern Ontario), Randy has been involved in a number of research projects that engage the community and incorporate Aboriginal values and perspectives. Reflecting his beliefs about the significance of Aboriginal self-determination, Randy helped develop CAAN’s position statement on Principles of Research Collaboration. His research interests include cultural competence in service provision, homophobia from the perspective of two-spirit women, cultural resiliency, Aboriginal participation in clinical trials, and mental health and depression. Thomas Kerr, PhD Thomas Kerr is the Director of the Urban Health Research Initiative at the BC Centre for Excellence in HIV/AIDS, Assistant Professor in the Department of Medicine at the University of British Columbia, as well as a Michael Smith Foundation for Health Research Scholar. At the BC Centre for Excellence in HIV/AIDS, Thomas is a principal investigator of several large cohort studies involving people who inject drugs and individuals living with HIV/AIDS, including the Vancouver Injection Drug Users Study. Thomas’s primary research interests are HIV/AIDS, injection drug use, health policy and service evaluation, and community-based research methods. A key focus of Thomas’s work has been the scientific evaluation of Insite, North America’s first safer injecting facility, and his research in this area has contributed significantly to academic, public, and government discussion, both nationally and internationally. Thomas has published over 200 scientific papers in international peer-reviewed journals and has received local and national awards for his contribution to public health, including the National Knowledge Translation Award from the Canadian Institutes of Health Research for his efforts to promote scientific discussion on illicit drug policy. Susan King, MD The OHTN is pleased to honour the life of Dr. Susan King, Professor of Paediatrics at the University of Toronto and a specialist in Paediatric Infectious Diseases at The Hospital for Sick Children, by establishing a permanent lecture series in her name. As the co-director of the HIV/AIDS Comprehensive Care Program at the Hospital for Sick Children, Susan always had a special focus on the care of families with HIV. Her passion was the care and treatment of children with HIV and pediatric-related HIV research. A tireless advocate for children and families affected by HIV, Susan was a founding member of the Canadian Paediatric AIDS Research Group and the coordinator of the Canadian Perinatal HIV Surveillance Program. Susan King died on February 15, 2009. Finding New Solutions in HIV Prevention, Treatment and Support 33 Biographies Marina Klein, MD Dr. Marina Klein graduated from McGill Medical School (1991) and received her training in Internal Medicine at the Royal Victoria Hospital (1991-94). She completed a research fellowship in Infectious Diseases at the University of Minnesota in 1998 and then returned to McGill University to join the Division of Infectious Diseases/ Immunodeficiency Service at the Royal Victoria Hospital. While on faculty she received a Master’s degree in Epidemiology and Biostatistics from McGill and was an Associate of the Canadian HIV Trials Network. She is a previous recipient of an MRC/CIHR New Investigator award and is currently supported by a Chercheur-boursier J2 award from the FRSQ. She focuses her research on clinical and epidemiologic aspects of HIV and Hepatitis C co-infection. With support from the FRSQ, she has established a prospective cohort of co-infected patients to study the interaction of these chronic viral infections which has recently been funded by the CIHR to expand across Canada. She also is also a principal investigator for clinical trials in the treatment of co-infection. Additional research interests include pharmacoepidemiology of antiretrovirals and HIV infection in women. David Lewis-Peart David Lewis-Peart is the Prevention Program Coordinator with the Black Coalition for AIDS Prevention (Black CAP) in Toronto. David is a graduate student at York University, where his focus of study is in Research, Program Evaluation, BMSM youth, and community interventions. David has worked as a social services counsellor and consultant over the past five years with organizations such as the Metro Action Committee on Violence Against Women, Central Toronto Youth Services, the Center for Addictions and Mental Health (SAPACCY), LOFT community services, and Fife House, and was the recipient of the TD Canada LGBT Youthline Award for Achievement in Social Services and Anti-oppression in 2008. David is the author of, Visibly Hidden: Rethinking BMSM and HIV Prevention, which has been used in the creation of programming and resources for young Black gay and bisexual men. It includes the THINK print media campaign, www.getthelowdown.ca; a sexual health website for young Black gay and bisexual men, the Dealing with Being Different: A Coming Out Resource Booklet for Black LGBT Youth and their Families. He also spearheaded the development of the Black Families and Friend (BFF) chapter of PFLAG Canada. Most recently, David launched Black CAP’s Toronto pilot of the group HIV/STI intervention, Many Men, Many Voices (3MV) for BMSM youth, which he is currently in the process of evaluating with Black CAP’s academic partners. Alan Li, MD Alan Li has been a primary care physician at Regent Park Community Health Centre since 1987. Between 1992 and 2000 he also worked at Casey House Hospice and was the medical director from 1997 to 2000. Alan is the founding president of the Asian Community AIDS Services, a former national president of the Chinese Canadian National Council, and a founding member of the Committee for Accessible AIDS Treatment (CAAT). Alan has also worked with the five ethnoracial AIDS service organizations in Toronto to form the Ethnoracial Treatment Support Network. Since 2005, Alan has been a community based research fellow at the Ontario HIV Treatment Network and is a leader in action research on immigrant, refugee and non-status PHA and culturally diverse communities in Canada. In recognition of his work, Alan was recently awarded the Humanitarian Award by the African Caribbean Council on HIV/AIDS in Ontario and the Council Award from the College of Physicians and Surgeons of Ontario. 34 RESEARCH AT THE FRONT LINES Biographies James Murray James Murray is a Senior Program Consultant at the AIDS Bureau, Ontario Ministry of Health and LongTerm Care. In this capacity, James has assisted with the development of the Gay Men’s Sexual Health Alliance, the strategy that developed and delivered the HIV Stigma Campaign. Prior to working at the AIDS Bureau, James worked at the AIDS Committee of Toronto coordinating community-based HIV prevention programming targeted to gay men. James holds an M. Ed from the University of Toronto. Suzanne O’Byrne Suzanne is presently employed at Somerset West CHC in Ottawa as Director, Community and Social Services, a large department providing services such as individual and group counseling, practical assistance, children and youth programs, mental health and harm reduction services. She was instrumental in bringing Success By 6 to Ottawa and held the position of Executive Director for 3 years prior to leaving for the position at Somerset West. Before this she had been the Director of Social Work for three municipal Homes for the Aged for 13 years, and for 12 years, the Director, Community Services for United Way/Centraide Ottawa, responsible for allocation of funds and community building initiatives. She holds a Master of Social Work from Carleton University, is fluently bilingual, and among other volunteer commitments, has been a member of the Board of Directors of St. Patrick’s Home and Carlington Community Health Centre in Ottawa. Mario Ostrowski, MD Dr. Mario Ostrowski awakens every morning with two nagging questions: 1) Why can’t our immune systems get rid of the virus if we get infected? and 2) Can we design an effective vaccine against HIV? Dr. Ostrowski’s research investigates how HIV can escape the body’s immune defenses, and how the virus cripples the immune system. In addition, his team is developing new ways of designing vaccines against this lethal virus. Graduating from the University of Western Ontario medical school, he went on to complete residencies in pathology, internal medicine and infectious diseases. He held a position of visiting scientist at the NIH prior to coming to the University of Toronto. He is part of a team of primary investigators whose work is defined as translational research, where patients are directly involved with trying to solve the puzzle of HIV. Because of the scope of the problem, his laboratory collaborates extensively with clinicians caring for HIV, and investigators at many centers including UCSF and the NIH. Sean B. Rourke Sean B. Rourke, Ph.D., completed his doctorate in 1995 in Clinical Psychology with a specialization in Clinical Neuropsychology at the University of California, San Diego. Sean is the Scientific and Executive Director of the Ontario HIV Treatment Network, a Scientist with the Centre for Research on Inner City Health, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital and an Associate Professor in the Department of Psychiatry at the University of Toronto. He is also the Director of the CIHR Centre for REACH (Research Evidence into Action For Community Health) in HIV/AIDS. In his role at the OHTN, Sean has carved out a key role as a leader and facilitator: identifying and exploring current and emerging issues in HIV prevention, care and treatment; building partnerships between researchers and the HIV community; actively promoting community-based research and mentoring community-based researchers; helping secure research funding; and assisting the community and academics in developing participatory research that will lead to improvements in the care, support, treatment and prevention of HIV in Ontario and Canada. In 2005, he received a New Researcher Award from the Ontario Ministry of Research and Innovation. Finding New Solutions in HIV Prevention, Treatment and Support 35 Biographies Charles Roy, PhD Active in the AIDS Movement from the early years of the epidemic, Charles Roy organized the first support group at the Montreal AIDS Resource Centre and was the social worker at the Hemophilia Clinic of the Montreal Children’s Hospital. Upon moving to Ontario, he was involved with numerous HIV organizations as a social worker, researcher, volunteer, board member and, eventually, the Executive Director of the AIDS Committee of Toronto. Diagnosed with HIV in 1987, Charles played an important leadership role in the Canadian PWA movement tirelessly advocating for the meaningful involvement of people with HIV in research and service organizations. Charles died of complications related to HIV/ AIDS in August 2002 after a professional and personal life dedicated to the AIDS movement, community based research, and social justice issues. Ron Stall, PhD, MPH Ron Stall is currently Professor and Chair of the Department of Behavioral and Community Health Sciences in the Graduate School of Public Health at the University of Pittsburgh. Dr. Stall’s central research interest is the study of how social and cultural forces shape the behaviors that place individuals at higher risk for disease outcomes. Stall began work in 1984 on the AIDS Behavioral Research Project, one of the first longitudinal studies of AIDS risk-taking behaviors in the world. Since that time he has published over 120 peer reviewed scientific papers on many different aspects of the AIDS epidemic. Stall is the 1999 recipient of the Chuck Frutchey Board of Directors Award from STOP AIDS/San Francisco. He is listed as one of the most highly cited behavioral science researchers in the world in the ISI Most Highly Cited website, received the 2005 CDC/ATSDR Honor Award for Public Health Epidemiology and Laboratory Research and was inducted into Delta Omega (a public health honor society) in 2006. His current research and teaching portfolio includes co-Directorship of a Certificate Program in LGBT Health, and PI or Co-PI status on a series of NIH grants on issues important to gay men’s health. Bonita Stanton, PhD Bonita Stanton is Schotanus Professor and Chair of the Department of Pediatrics at Wayne State University and Pediatrician-in-Chief at Children’s Hospital of Michigan. Dr. Stanton graduated from Wellesley College and Yale University School of Medicine. She received her pediatric residency training at Rainbow Babies and Children’s Hospital and completed an infectious disease fellowship at Yale University. She served as the Medical Director of Yale’s Hill Health Center and then went to Dhaka, Bangladesh for five years where she served as Director, Urban Volunteer Program, a program directed towards the health of Bangladeshi’s living in the slums of Dhaka Bangladesh, and as the World Bank Maternal Child Health Specialist for Bangladesh. She was then on faculty at the University of Maryland until she became Chair, Department of Pediatrics, West Virginia University. In 2002, she moved to her current position. Dr. Stanton has consulted with numerous national and international groups including the World Bank, WHO, UNICEF, and USAID on issues related to urban health, HIV/AIDS transmission in youth, maternal child health, vaccines and health services research. She has been an author of over 200 articles as well as other chapters, reports and books. She is an editor of the 18th and 19th editions of Nelson Textbook of Pediatrics. She is a member of the Advisory Board to The Fogarty International Center at the National Institutes of Health. 36 RESEARCH AT THE FRONT LINES Biographies James Watson James Watson is a project coordinator at the OHTN, currently overseeing the Positive Spaces Healthy Places (PSHP) study, Phase III, and contributing to the Impacts of Criminal Prosecutions for HIV Exposure and Transmission on People Living with HIV study. He comes to this work following experiences as a Peer Research Assistant with PSHP Phase I & II and Research Assistant for the Sustaining Health Sustaining Housing study conducted at Fife House. He has presented at the OHTN Research Conference, AIDS 2008 and CAHR. After 18 years of living with HIV, James is motivated to share his experience moving off of disability, returning to school and engaging in Community Based Research. A paper he co-authored, Between Skepticism and Empowerment: The experiences of Peer Research Assistants in HIV/AIDS, Housing and Homelessness Community-Based Research was recently published in the International Journal of Social Research Methodology and his paper HIV Capacity Building: Reclaiming Our Confidence was published in HIV Australia. He holds a BFA from the University of Windsor and is currently completing a diploma in Community Development. Zhaida Uddin, BSc. (Hons), M.A Zhaida Uddin has worked in HIV/AIDS since 1995, developing awareness campaigns, educational materials, training guidelines, position statements, policy papers, reports for community-based organizations and the City of Ottawa. Zhaida currently works with Ottawa Public Health, as a Project Officer with the Special Initiatives Team, and over the last 5 years her focus has been around raising awareness of the specific vulnerabilities the African and Caribbean communities face around HIV/AIDS as well as youth, and providing prevention information and programming to the community through partnership with other organizations in Ottawa. In 2004, she initiated the design and implementation of ‘Operation Hairspray: an innovative community approach to HIV/AIDS prevention education with African and Caribbean communities’, which has been an extremely successful initiative. Zhaida is also a member of a number of provincial and local committees that focus on policy, advocacy and programme development to raise awareness of and respond to the HIV prevention needs of the African and Caribbean communities in Ottawa and Ontario. Juan Carlos Zúñiga-Pflücker, PhD Dr. Juan Carlos Zúñiga-Pflücker is a Senior Scientist at the Sunnybrook Research Institute and a Professor in the Department of Immunology at the University of Toronto. He holds a Tier-1 Canada Research Chair in Developmental Immunology, and is the Director of the Advance Regenerative Tissue Engineering Centre. Dr. Zúñiga-Pflücker’s work, which focuses on the development of the immune system, led to the discovery of how to generate T lymphocytes from stem cells in a tissue culture without a thymus. Dr. Zúñiga-Pflücker received his PhD in genetics and immunology from the George Washington University, Washington, D.C. As a graduate student, Dr. Zúñiga-Pflücker studied the cellular interactions of thymus function at the National Institutes of Health in Bethesda, Maryland. He went on to complete his postdoctoral studies also at the NIH, looking into transcriptional regulation in early T cell development. Since his faculty appointment, his laboratory has pursued a research program to uncover the molecular control of lymphopoiesis and thymus biology, which have led to the publication of several groundbreaking papers demonstrating a role for Notch ligands in T cell development and in embryonic stem cell differentiation. Finding New Solutions in HIV Prevention, Treatment and Support 37 Posters Alhetheel, Abdulkarim. Regulation of Programmed Cell Death in Monocytes from HIV+ Patients by Interferon-γ and Interleukin-10, 343 Ambagala, Aruna. A Self-boosting Cytomegalovirus (CMV) Vector in the Development of a Protective Human Immunodeficiency Virus (HIV) Vaccine, 364 Andany, Nisha. Implementation of a Student-Initiated Preclerkship HIV Elective, 337 Arendt, Bianca. HIV-Associated Non-Alcoholic Fatty Liver in the Era of Highly Active Antiretroviral Therapy: A Review, 312 Ashraf, Tamima. Regulation of P-Glycoprotein Expression by the Viral Envelope Protein gp120 and Pro-Inflammatory Cytokines in Human Glial Cells, 357 Au-Yeung, Christopher. Tuberculosis Mortality in HIV-Infected Individuals: an Analytical Assessment, 313 Baidoobonso, Shamara. The Black, African and Caribbean Canadian Health (BLACCH) Study: Phase I, 320 Balfour, Louise. High Rates of Smoking and Depression Co-Occur Among People Living with HIV in Canada, 314 Blahoianu, Maria. Regulation of IL-23 in Human Monocytes Following HIV Infection, 345 Buhler, Shayna. The Impact of AIDS Vaccine Research on Health Systems Strengthening, 365 Busca, Aurelia. Monocytes to Macrophages Differentiation Confers Resistance to HIV-VPR Induced Apoptosis: Role of AntiApoptotic BCL2 and Inhibitors of Apoptosis (IAP) Proteins, 358 Calla, Domenico. Condoms and Community: Enhancing Community Engagement to Inform Public Health Practice and Condom Distribution, 338 Challacombe, Laurel. Increasing Community Knowledge of HIV and Legal Disclosure in an Era of Criminalization, 339 Che Mat, Nor Fazila. Regulation of IL-23 Induced Signaling and Receptor Expression in Human CD4 T Cells Isolated from HIV Positive Patients, 346 Cochrane, Alan. Different Roles of hnRNP D Isoforms in Modulating HIV-1 Gene Expression, 362 Corace, Kim. From Stigma to Disability: The Role of Depression Among PHAs, 334 De Rosa, Maria Fabiana. Role of Membrane Drug Transporters in the Permeability of Microbicides, 377 Duffy, Simon. Detecting Novel Sam68∆C-Associated Proteins Involved in Disrupting HIV-1 Replication, 360 Fairman, Peter. Effects of HIV-1 on the Maturation and Antigen Presentation of Monocyte Derived Dendritic Cells, 347 Faucher, Sylvie. Development of a Quantitative Bead Capture Assay for Soluble IL-7 Receptor Alpha in Human Plasma, 348 Ferreira, Victor. The Effect of HSV-2 Infection on HIV Replication in the Female Genital Tract, 315 Forbes, Rosemary. The Broader Determinants of Health in an Aboriginal Context, 322 Furlotte, Charles. “Got a Room for Me?” Housing Experiences of Eleven Older Adults Living with HIV/AIDS in Canada’s Capital City, 327 Ghazawi, Feras. Effects of Interleukin-7 on Notch-1 Expression in CD8 T-Cells, 349 Gray, Kimberly. Risk Behavior Among EAST (East African Health Study in Toronto) Participants with Multiple and Concurrent Sexual Partners, 329 Guzzo, Christina. The Effect of HIV Infection on Expression Levels of the Interleukin-27 Heterodimeric Cytokine and Receptor, 350 Hard, Julie. Interprofessional Mentorship as a Means to Build Capacity Among Rehabilitation Professionals and People Living with HIV in Ontario, 335 Hart, Trevor. Gay Poz Sex: A Community Based Counseling Intervention for HIV-Positive Men, 331 Henrick, Bethany. Understanding the Role of Innate Factors in Mother-to-Child HIV-Transmission through Breast Milk, 308 Johnston, Christine. Building a Collection of “Evidence”-Based HIV Front-Line Practices: The Programming Connection – Shared Experience. Stronger programs, 341 Jones, Angeline. HIV Prevention and the African and Caribbean Diaspora, 369 Julien, Jean-Philippe. Probing the Promiscuity Displayed by the Broadly Neutralizing anti-HIV-1 Antibody 2F5 in Recognizing a Variety of gp41 MPER-Related Peptides: a Basis for the Design of Small Molecule Vaccines, 366 Kafka, Jessica. Effect of Seminal Plasma from HIV-Infected Men on Female Genital Epithelial Cell Responses, 378 Kakal, Juzer. Regulation of the IL-7 Receptor Alpha Chain in Primary Human Cytotoxic T-Cells, 304 Kis, Olena. Uptake of Atazanavir (ATZ) is Susceptible to Inhibition by Antiretroviral Drugs in Caco-2 Cells, a Model of Human Intestinal Epithelium, 374 Krahn, Thomas. The Diagnostic Utility of Serum RPR Titer and Peripheral CD4 Cell Count for Neurosyphilis Among Patients with HIV: A Systematic Review, 316 38 RESEARCH AT THE FRONT LINES Posters Liu, Jun. The Adjuvancy of OX40 Ligand (CD252) on an HIV-1 Canarypox Vaccine, 367 Lo, Calvin. HIV Induces a Unique Cytokine Profile with Delayed Interferon Alpha Production in Plasmacytoid Dendritic Cells, 351 Lombardo, Anthony. Online Sex Seeking Among MSM: Subculture and Socialization, 375 Marsh, Angie. Endogenous Retroviral Element (ERV) Antigens: Immunological Targeting of HIV-Infected Cells, 368 McDiarmid, Marney. PhotoPositive: Exploring HIV-Related Stigma Within Communities of Gay and Bisexual Men in Toronto, 302 McLaughlin, Denny. Expression of the Interleukin-7 Receptor is Down Regulated on CD4 T-Cells by the HIV Tat Protein, 353 Mujib, Shariq. Induction of Tim-3 Expression by the Common Gamma-Chain Cytokines IL-2, IL-7, IL-15 and IL-21, 352 Mwalwanda, Mary. 50+ Years as Women Living With HIV-Case Managers Provide a ‘wHEALTH’ of Experience, 307 Ndlovu, Uitsile. “Nobody tell me and I don’t ask” –The Experiences of African/Caribbean Black Muslim Women with Prenatal HIV Testing in Ontario, 317 Nixon, Stephanie. Taking Seriously Our Obligations to Share Research Results: One Approach to Knowledge Transfer and Exchange with Adolescents, 370 O’Brien, Kelly. Developing a New HIV Disability Questionnaire: A Community-Integrated Approach, 333 O’Brien, Kelly. Enhancing Labour Force Participation for People Living with HIV in Canada: Scoping Review Results, 326 O’Brien, Kelly. Exploring Relationships Between Dimensions and Contextual Factors of Disability: Development of a Measurement Model, 336 O’Brien, Nadia. Moving from Paradigm to Practice: The Ashodaya Sex Worker Empowerment Project in Mysore India and its Promise for HIV/AIDS Prevention, 371 O’Brien, Nadia. Overcoming Employment Barriers: Health and Financial Worries Among a Cohort of HIV-Positive Individuals on HAART, 321 O’Loghlen, Sean. A Comparison of Antiretroviral Treatment Uptake in HIV Patients that are Canadian-Born and those Born Outside Canada, 376 Parashar, Surita. The Effect of Medication Support Services on the Association Between Housing and Adherence Among a Cohort of Unstably Housed People Living with HIV/AIDS Accessing HAART, 323 Petrovic, Bojana. HIV Risk Behavior Among Undergraduate Students During Reading Week Vacation, 330 Popiel, Melissa. HIV and Employment Activity in Canada: A 2009 Survey, 324 Rebbapragada, Anu. Detection of Human Papilloma Virus in Self Collected Vaginal and Anal Samples from Afro-Caribbean Women Residing in Toronto, 318 Robillard, Kevin. Expression of ABC Drug Efflux Transporters in a HIV-1 Transgenic Rat Model, 361 Rueda, Sergio. Job Security is Associated with Quality of Life in Men Living with HIV: The OHTN Cohort Study, 379 Salit, Irv. Cost-Effectiveness of Anal Cancer Screening in HIV-Positive Men, 332 Sandre, Daniella. The Ottawa HIV Quit Smoking Program, 340 Saxena, Mansi. TLR-9 Agonist Protects Human Monocytic Cells against HIV-Vpr-induced Apoptosis: A Critical Role for Calmodulin-dependent Protein Kinase-II and an Anti-apoptotic cIAP-2 Gene, 354 Scott, Allison. Peer Investigator Experiences in a Community Based Research Study: Expression Through Creative Projects, 303 Sharpe, Simon. Identification of the Oligomerization Interface in the Transmembrane Domain of HIV-1 Vpu, 359 Singhal, Neera. The Effect of Mixed Carotenoids Supplementation on CD4 T Lymphocyte Count in HIV/AIDS, 355 Sok, Phan. Clinical Outcomes Prior to the Era of Antiretroviral Therapy in Cambodia, 372 Song, Haihan. HIV-1 Increases Non-LTR Associated long Interspersed Element 1 Expression by Retrotransposition, 363 Taggart, Linda. Changes in the Incidence and Outcomes of Hematologic Malignancies in Individuals with HIV in the cART Era, 319 Tebeje, Meskerem. Harm Reduction Theatre Troupe Project, 301 Tebeje, Meskerem. Reaching Vulnerable Women in Priority Areas in the Greater Toronto Area: Voices of Positive Women’s Community Connections Project, 306 Tebeje, Meskerem . Using Art to Educate the Youth and Open-up a Dialogue re: HIV/AIDS in the Ethiopian-Canadian Community, 305 Tenywa, Paul. Access to HIV/AIDS Resources by Mothers and Children: Lessons from Rural Communities in Uganda, 373 Wagner, Anne. Correlates of Psychological Distress in HIV Positive (HIV+) Women, 310 Wilson, Michael. Mobilizing Evidence at the Front Lines: Improving HIV/AIDS Policy and Care in Canada, 342 Wolfert, Stephanie. Optimizing Prenatal HIV Testing in Ontario, 311 Young, Charlene. In Vitro HIV Infection Results in Impaired IL-7 Signaling in Primary Human Thymocytes, 356 Finding New Solutions in HIV Prevention, Treatment and Support 39 Acknowledgements The OHTN Gratefully Acknowledges the Following People for their Contributions to the Conference: Barry Adam Charles Collins David Lewis-Peart Stanley Read Jonathan Anderson Marisol Desbiens Alan Li Allison Scott Jonathan Angel Lynette Deveaux Mona Loutfy Ron Stall Maggie Atkinson Nicole Greenspan Frank McGee Bonita Stanton Greta Bauer Tim Guimmond James Murray Darien Taylor Gerardo Betancourt Adrian Guta Kelly O’Brien Robb Travers David Brennan Randy Jackson Treena Orchard Zhaida Uddin Roy Cain Llana James Mario Ostrowski James Watson Liviana Calzavara Ashok Kumar Suzanne O’Byrne David Wille Robert Carr Thomas Kerr Angel Parks Juan Carlos Zuniga-Pflucker Lisungu Chieza Marina Klein Anita Rachlis Moderators of Concurrent Sessions Oral Abstract Presenters Special Thanks Conference Planning Committee 40 RESEARCH AT THE FRONT LINES Poster Presenters The Ontario HIV Treatment Network is funded by the AIDS Bureau, Ministry of Health and Long-Term Care