CURRICULUM VITAE
SATYA P. KALRA, Ph.D.
MARCH, 2012
VITAE ORGANIZATION
Section
Description
Page Number
Biographical Data ........................................................................................... 1
I
Academic Appointments ................................................................................. 1
II
Honors ...................................................................................................... 2-22
1. Awards
2
2. Bench to Bedside Translation
3
3. Chaired National and International meetings
4
4. Editor, Journals; Editorial Boards
6
5. Invited Editor-Books
7
6. Plenary Lectures
8
7. Invited Participant
A. International Meetings
9
B. National Meetings
14
C. Departmental Seminar Series
17
8. Recognition of Published Articles: Citation Classic
21
9. Society Memberships
22
10. Organizer of Scientific Meetings
23
III
Administration and Services ................................................................... 24-27
Reviewer
1. Research Committees
24
2. Journals
25
3. Committees (National and International)
26
IV
Teaching - Research Training ................................................................ 28-29
1. Teaching activity
28
2. Research Training
A. Post-Graduate Fellows and Associates
28
B. Co-Supervisor for Graduate Degree
28
C. Supervisor for Committees for Graduate Degree
28-29
D. Supervisory Committee for MS Degree
29
V
Research ................................................................................................ 30-72
1. Research Interests
31
2. Research Grants
31
3. Publications
A. Reviews and Book Chapters
32
B. Refereed Publications
39
C. Abstracts of Papers Published
57
CURRICULUM VITAE
NAME:
Satya Paul Kalra
TITLE:
Distinguished Professor
Department of Neuroscience
University of Florida College of Medicine
Gainesville, FL 32610-0244
MARRIED:
1969, Pushpa S. Kalra
CHILDREN:
Son, Anjay
EDUCATION:
1966
Ph.D., University of Delhi, India
1968-1969 Post-doc. Res. Fellow in Neuroendocrinology of Reproduction, Department of Anatomy,
School of Medicine, University of California, Los Angeles, CA
1969-1971 Post-doc. Res. Fellow in Neuroendocrinology of Pituitary Functions, Department of
Physiology, S.W. Medical School, University of Texas, Dallas, TX
I.
ACADEMIC APPOINTMENTS:
1966-1968 Research Associate, University of Delhi, India
1971-1976 Assistant Professor, Department of Obstetrics and Gynecology, University of Florida
College of Medicine.
1976-2005 Member, Graduate School Faculty, University of Florida
1976-1981 Associate Professor, Department of Obstetrics and Gynecology, University of Florida
College of Medicine.
1982-2000 Adjunct Professor, College of Pharmacy, University of Florida
1982-1993 Professor, Department of Obstetrics and Gynecology, University of Florida College of
Medicine.
1990-2005 Professor, Department of Physiology (joint appointment), University of Florida College of
Medicine, Gainesville, FL
1993-2005 Professor, Department of Neuroscience, University of Florida College of Medicine,
Gainesville, FL
2005-Present
Distinguished Professor, Department of Neuroscience, University of Florida
College of Medicine, Gainesville, FL
2006-present
Distinguished Professor Emeritus, Department of Neuroscience, University of
Florida College of Medicine, Gainesville, FL
1
HONORS:
II.
1.
Awards:
1963-1966
Junior Research Fellowship, Council of Scientific and Industrial Research,
India.
1968-1971
Ford Foundation Postdoctoral Fellowship
1981
Visiting Professor, Department of Physiology, University of California
School of Medicine, San Francisco (collaborative research with Dr. R.V.
Gallo).
1982
Visiting Professor, Department of Anatomy and Obstetrics & Gynecology,
Duke University, Durham, NC (collaborative research with Drs. J.W.
Everett and L. Tyrey)
1971-1974
Population Council Grant Awards
1975-2005
PI on two Concurrent National Institutes of Health Research Grant Awards.
1979-2005
Co-PI on two Concurrent National Institute of Health Grant Awards.
1984
First Edition Marquis Who=s Who
1987
U.S. Patent #4,701,441 "Methods and Composition of Stimulation of
Appetite"
1990
U.S. Patent #4,891,357 "Methods and Composition of Stimulation of
Appetite with Neuropeptide Y".
1996
Faculty Research Prize in Basic Science for Outstanding Achievements and
Productivity in Research, College of Medicine University of Florida
1996
Professional Excellence Program Award for outstanding achievements in
research, teaching and service, University of Florida
1999-2001
University of Florida Research Foundation Award, University of Florida
2001
Merit Award, University of Florida
2001
College of Medicine nominee for 3rd Annual Bristol - Myers Squibb Award
for distinguished Research in Metabolic Research.
2005
Distinguished Professor Award, University of Florida
2006
Senior Faculty Research Award, Florida Chapter of Sigma Xi.
2
HONORS (Cont.)
2.
BENCH - TO - BEDSIDE TRANSLATION:
1. Discovery for the first time of:
1) Appetite Stimulating effects of Neuropeptide Y (Endocrinology
115:427, 1984),
2) Mediation by NPY Y1 receptor (Regulatory Peptides, 17:31-39,
Physiol. Behav., 50:51994),
3) NPY is a physiological appetite transducer (Peptides: 9:83, 1988,
PNAS, 88:1093, 1991).
These discoveries have triggered development of NPY Receptor
antagonists as "Appetite Suppressant" drugs by several
pharmaceutical companies.
2. Demonstration for the first time that central administration of ciliary
neurotrophic factor (CNTF) inhibits appetite by suppressing orexigenic
NPYergic synthesis and release, with little side effects (Xu et al
Endocrinology 139:466, 1998, Pu et al J. Neuroendocrinology 12:827,
2000, PNAS, 98:4279, 2001)
This discovery has led to REGENERON, INC. to employ Axokine (an
analog of CNTF) as a long-term weight-reducing drug. Undergoing Phase
III clinical trials.
3. Demonstration for the first time that leptin gene therapy in the
hypothalamus alone can ameliorate diabetes type 1 and 2and increases
lifespan (Gene Therapy, 18:319, 2011).
This discovery has led to ongoing clinical trials with leptin therapy to
replace currently in-vogue insulin therapy.
3
HONORS (Cont.)
3.
CHAIRED NATIONAL AND INTERNATIONAL CONFERENCES:
1.
CO-CHAIRMAN, Session entitled "Neurotransmitters in the Control of Pituitary Hormone
Secretion", VIth International Congress of Endocrinology, Melbourne, Australia, 1980.
2.
CO-CHAIRMAN, Session entitled "Neuroendocrine Regulation of LH", 1st International
Congress of Neuroendocrinology, San Francisco, CA., July 9-11, 1986.
3.
CO-CHAIRMAN, Session entitled "The Opiates", 19th Annual Meeting of the Society for the
Study of Reproduction, Ithaca, NY, July 14-17, 1986.
4.
CHAIRMAN, Session entitled "Neuroendocrinology I" at the 23rd Annual Meeting of the
Society for the Study of Reproduction, Knoxville, TN, 1990.
5.
CHAIRMAN, Session on "Ingestive Behavior: Peptide II", 20th Annual Meeting Society for
Neuroscience, Atlanta, GA, Oct. 28 - Nov. 2, 1990.
6.
CHAIRMAN, Session: "Hypothalamus-Pituitary-Gonadal Regulation I", 21st Annual Meeting
Society for Neuroscience, New Orleans, Nov. 11-5,, 1991.
7.
CHAIRMAN, Session on "Neural Control of Menstrual Headaches". 3rd World Congress of
Gynecological Endocrinology, Madonna di Campiglio (ITALY), February 9-16, 1992.
8.
CHAIRMAN, Session on "Hypothalamic Neurotransmitters". 1st International Symposium on
Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria, July 17-24, 1992.
9.
CHAIRMAN, Symposium on "Novel Steroid Actions on the Brain", Ninth International
Congress of Endocrinology, Nice, France, August 30-September 5, 1992.
10.
CHAIRMAN, Session on "Neural Mechanisms Controlling Gonadotropin Secretion", July 6,
1995, Nagoya Symposium on Brain Control of the Reproductive System, Nagoya, Japan,
July 5-7, 1995.
11.
CHAIRMAN, Session on "Neurosteroids: Clinical Implication." May 13, 1996. 1st Tuscania
Conference on Reproductive Medicine: The Brain: Source and Target for Sex Steroid
Hormones. Pisa, Italy, May 13-14, 1996
12.
CHAIRMAN, Sessions on "NPY and the Neuroendocrine System." 5th International NPY
Meeting, Grand Cayman, BWI, April 17-22, 1999
13. CHAIRMAN, Session on "Contraceptive effects of antigestogens". 9 th World Congress
of Gynecological Endocrinology, Hong Kong, Dec. 2-5, 2001.
14. CHAIRMAN, Session on "Oral Communication". Symposium "Digestive hormonal,
appetite and energy balance." London, England, June 30 - July 1, 2003.
4
15.
Chairman, Session on "Obesity and Metabolic Diseases". 9th NPY Meeting, Okinawa,
Japan, March 16-20, 2008.
16.
Chairman, Session on “Diabetes scourge: hypothalamic NPY signaling as a therapeutic
target,” The10thconference on NPY-PYY-PP meeting. Montreal, Canada, June 30-July 4,
2012
5
HONORS (Cont.)
4.
EDITOR
Editor for North America: Journal of Neuroendocrinology, 1989 - 2002
EDITORIAL BOARDS:
NEUROENDOCRINOLOGY, 1986-1989
ENDOCRINOLOGY, 1987-1988
ENDOCRINE REVIEWS, 1993-1996
REGULATORY PEPTIDES, 2000 - present
PEPTIDES, 2000 - Present
SPECIAL ADVISORY COMMITTEE OF EDITORIAL BOARD OF ENDOCRINE JOURNAL, Japan,
2000-Present
CURRENT MEDICINAL CHEMISTRY 2004- 2006
6
HONORS (Cont.)
5.
INVITED EDITOR
BOOKS:
1.
Co-Editor: "Regulation of Ovarian and Testicular Function, Advances in Experimental
Biology and Aging. Mahesh, V.B., Dhindsa, D.S., Anderson, E. and Kalra, S.P. (Eds.),
Plenum Publishing Co., NY, Vol. 219, pp 1-761,1987.
2.
Editor: NeuroProtocols, "Steroid Feedback Mechanisms", Academic Press, San
Diego. Series Editor: P.M. Conn, pp 1-97, 1992.
3.
Editor: ANeuropeptide Y", Special Issue, Regulatory Peptides, (54articles), 75-76:1458, 1998
4.
Co-Editor: "Novel Peptides in Obesity-Leptin", Special Issue, Regulatory Peptides, (18
articles), 92:1-119, 2000.
5.
Editor: "Neuropeptide Y, Evolution and Pleiotropic functions of NPY and related
Peptides," Special Issue, Peptides, (34 articles), 22:293-556, 2001.
6.
Co-Editor. “Update on Ghrelin” A. Inui, S. Fetissov, A. Laviano and S. Kalra(Eds)
Hindawi Publishing incorporation, 2010 .
.
BOOK REVIEW:
1.
"The Brain as an Endocrine Organ", Cohobern, M.P. and Foa, P.P. (eds) Quarterly
Review of Biology, 65:251, 1990.
7
HONORS (Cont.)
6.
Plenary Lectures:
1.
Opening Plenary Lecture at the 4th International NPY conference, October 13-14,
1997, London, England. Title of Presentation: "NPYBA Novel Pleiotropic Peptide
Signal in the CNS".
2.
Plenary Session at the 6th International NPY Conference, April 22-26, 2001, Sydney,
Australia. Title of Presentation: "The NPY road, a fascinating, pleiotropic journey".
3.
Plenary Session at the 9th World Congress of Gynecological Endocrinology,
December 2-5, 2001, Hong Kong. Title of Presentation: "Leptin, Hypothalamus,
Obesity and Reproduction".
4.
Plenary Session at the 4th International Symposium on GH Secretagogues, November
7-10, 2002, Clearwater, FL. Title of Presentation: "NPY as an orexigen".
5.
Opening Plenary Lecture at the International Symposium: New Frontiers in
Neuroendocrinology, March 16-18, 2003, Milan, Italy. Title of Presentation:
"Neuroendocrine Mechanisms: New Facts on Old Concepts".
6.
Opening Plenary Lecture at the 8th NPY Meeting on "NPY and Cohorts in Human
Disease", April 22-26, 2006, St. Petersburg, Florida. Title of Presentation: "To
Subjugate NPY is to improve the quality of life and live longer".
8
HONORS (Cont.)
7.
INVITED PARTICIPATION
A. INTERNATIONAL MEETINGS:
1.
Vth International Congress of Endocrinology. Hamburg, W. Germany, July 18-24,
1976. Title of presentation: "Neuroamines in Gonadotropin Secretion".
Symposium on Neurotransmitters and Pituitary Functions.
2.
XXVII International Congress of Physiological Sciences, Paris France, July 18-23,
1977. Title of presentation: "Hypothalamic catecholamine system and luteinizing
hormone releasing hormone secretion." Symposium on Neurotransmitters and
Endocrine Functions.
3.
Satellite Symposium, Montpelier, Fence, July 11-15, 1977. Title of presentation:
"Central neural control of endocrine rhythms in the rat." Symposium on
Environmental Endocrinology.
4.
International Society for Biochemical Endocrinology, Dubrovnick, Yugoslavia,
September 21-27, 1980. Title of presentation: "Mode of opioid and Catecholamine
Involvement in Regulation of LH and Prolactin Secretion." Symposium on
Hormonally Active Brain Peptides.
5.
II Pan American Congress of Andrology, Mexico City, January 26-30, 1981. Title of
presentation: "Modulation of LHRH secretion by gonadal steroids in the male
rat." Symposium on Male Neuroendocrinology.
6.
International Symposium on Pituitary Hormones and Related Peptides: From Cell
Biology to Clinical Application. San Marino, Italy, May 24-26, 1981. Title of
presentation: "Stimulatory role of gonadal steroids on LHRH secretion."
7.
International Society for Biochemical Endocrinology, Geilo, Norway, September 19-23,
1982. Title of presentation: "Hypothalamic microenvironment controlling LHRH
secretion." Symposium on Regulation of Target Cell Responsiveness.
8.
III Pan American Congress on Andrology, Columbia, South America. January 30February 4, 1983, Session Chairman.
9.
1st International Meeting of the Italian Society for Endocrinology: Recent Progress in
Opioid Research. October 3-6, 1983, Florence, Italy. Title of presentation: "Control
of LH secretion by endogenous opioid peptides."
10. International Symposium on Gonadotropin Releasing Hormones in Control of Fertility
and Malignancy, Hyderabad, India, August 17-20, 1984. Title of presentation: "Neural
circuits in the control of gonadotropin secretion."
11. XII meeting of the International Study Group for Steroid Hormones. Title of
Symposium: "Peptide Steroid Interaction", December 2-4, 1985, Rome, Italy. Title of
9
presentation: "Interactions between brain peptides and sex steroids in the
control of pituitary function."
12. 7th International Congress on Hormonal Steroids. Title of Symposium: "Integration of
Steroids and Neurotransmitter Systems in the Brain." September 21-26, 1986,
Madrid, Spain. Title of presentation: "Modulation of Aminergic-peptidergic
Interactions by Gonadal Steroids."
13. IV Pan American Congress of Andrology and Serono Symposium on Human
Reproduction, Sao Paulo, Brazil, May 3-6, 1987. Title of presentation: "Brain Signals
in the Regulation of Male Sex Behavior."
14. 8th International Symposium of the Journal of Steroid Biochemistry: Recent Avenues
in Steroid Biochemistry", Paris, France, May 24-27, 1987. Title of presentation:
"Gonadal Steroids and Opioid-Neuropeptide Y-LHRH axis: Interactions and
diversities."
15. 6th International Catecholamine Symposium. Jerusalem, Israel, June 14-19, 1987.
Title of presentation: "NPY Catecholamine-Steroid Link in the Control of LH
Release."
16. Symposium on: "Brain Opioid Systems in Reproduction", Babraham Conference
Center, Cambridge, England, September 6-9, 1987. Title of presentation: "Opioids in
the Steroid-Adrenergic Circuit Regulating LH Secretion: Dynamics and
Diversities."
17. Nobel Conference on "NPY and Other Related Peptides", Stockholm, Sweden, August
11-13, 1988. Title of presentation: "Hypothalamic NPY: A Local Circuit in the
Control of Reproduction and Behavior."
18. Symposium on Neuroendocrine Factors in Testicular Control, IV International
Congress of Andrology, Florence, Italy, May 14-18, 1989. Title of presentation:
"Neuropeptidergic Control of Gonadotropin Secretion: Facilitation by
Androgens."
19. International Conference on Frontiers in Reproductive Physiology, New Delhi, India,
November 8-10, 1990. Title of Presentation: "Neural and Immune Network in the
Control of Ovulation."
20. 3rd World Congress of Gynecological Endocrinology, Madonna di Campiglio (Trentino,
Italy), February 9-16, 1992. Titles of 2 presentations:
1. "Opioid Control of LH Secretion"
2. "Immune-Endocrine Interactions in Pituitary Function."
21. 1st International Symposium on Neurobiology and Neuroendocrinology of Aging.
Bregenz, Austria, July 19-14, 1992. Title of presentation: "Aging of the
Neuropeptidergic Signals".
10
22. 11th International Conference on the Physiology of Food and Fluid Intake. University
of Oxford, England. July 28-30, 1993. Title of presentation: "Is NPY a Physiological
Appetite Transducer?"
23. The Benjamin Franklin/Lafayette Seminar, La Napoule, France, May 29 - June 4,
1994. Title of presentation: "An Orexigenic Neuropeptide Y-galanin-opioid
network in the hypothalamus."
24. IIIrd International Congress of Neuroendocrinology, "Vasoactive Mechanism in
Neuroendocrinology" Symposium, Budapest, Hungary, July 3-8, 1994. Title of
presentation: "Nitric Oxide, Neuropeptides and Pituitary Hormone Secretion."
25. 14th Joint Meeting of the British Endocrine Societies, "Neuroendocrine Control by
Excitatory Amino Acids and Nitric Oxide Symposium" University of Warwick, UK,
March 27-30, 1995. Title of presentation: "Control of the LH surge."
26. Nagoya Symposium on Brain Control of the Reproductive System, Nagoya University,
Japan, July 5-7, 1995. Title of presentation: "Novel Neuroendocrine Signals in the
Control of Gonadotropin Secretion."
27. International Workshop on Brain: Source and Target for Sex Steroid Hormones, May
13-15, 1996, Pisa, Italy. Title of presentation: "Gonadal Steroids promote
interactive communication."
28. Symposium on the Study of Reproduction in Domestic Animals, "Oestrus Behavior:
Psychological and Physiological Backgrounds and Detection Methods." June 14,
1996, Institute for Animal Science, Lelystad, The Netherlands. Title of presentation:
"Neural Control of Reproduction and Estrous Behavior: Impact of Energy
Imbalance."
29. Workshop on "NPY antagonists - A new class of appetite suppressants", January 19,
1998, Basel, Switzerland. Title of Presentation: "Which receptor subtypes are
involved in NPY-induced feeding--A review of the evidence".
30. A. Wenner-Gren Center International Symposium on galanin: Basic Research
Discoveries and therapeutic Implications, May 3-5, 1998, Stockholm, Sweden. Title of
Presentation: "Neuroendocrine interactions between galanin, opioids, and NPY".
31. 4th Annual Meeting of the International Society of Neuroendocrinology: Symposium on
"Nutrition Signals, Feeding, and Reproduction", October 10-16, 1998, Kitakyushi,
Japan. Title of Presentation: "Interactive Pathways in the Hypothalamic Control of
Appetite and Reproduction".
11
32. Satellite Symposium on "Gonadotropins, GnRH Analogues", October 12-16, 1998,
Seoul, Korea. Title of Presentation: "Interactive Language of the Hypothalamus
for GnRH Secretion".
33. 5th International NPY Meeting Symposium on "NPY and Receptors in Neuroendocrine
Control", April 17-22, 1999, Cayman Islands, BWI. Title of Presentation: "Putting It
All Together".
34. 5th International NPY Meeting Symposium on "Feeding Receptor Debate", April 17-22,
1999, Cayman Islands, BWI. Title of Presentation: "NPY is Essential to Natural
Feeding".
35. 5th International Conference on the Control of the Onset of Puberty, September 26-29,
1999, Liège, Belgium. Title of Presentation: "Leptin and NPY Regulation of GnRH
Secretion".
36. Second International Symposium on Gonadotropin releasing hormone (Molecules and
Receptors), June 2-4, 2001, Shangri-La Roasa Sayong Resort, Penang, Malaysia.
Title of Presentation: "Afferents to GNRH neurons".
37. Symposium on New Treatments of Obesity at the 10 th World Congress on the
Menopause, June 10-14, 2002, Berlin, Germany. Title of Presentation: "Gene
therapy for appetite and body weight regulation: all in the brain".
38. Digestive Hormones, Appetite, and Energy Balance Symposium, 30 June-1 July,
2003, Wolfson Conference Centre Hammersmith Hospital London, UK. Title of
Presentation: "Central leptin gene therapy - A new modality to reinstate energy
homeostasis".
39. International Multidisciplinary Symposium "Peptide Receptors-Montreal 2004, from
Genes to Therapy" July 31- August 4, 2004, Montreal, Canada. Title of Presentation:
"Keeping obesity and metabolic syndrome at bay with hypothalamic gene
therapy".
40. Plenary Session at the Joint Meeting of the Society for Light Treatment and Biological
Rhythms and American Academy of Medical Chronobiology and Chronotherapeutics,
May 28 - May 30, 2004, Toronto, Canada. Title of Presentation: "Eating disorders
and obesity, are they a consequence of environmentally-imposed deranged
communication between peripheral and hypothalamic, pathways"?
41. First International Congress on Applied Chronobiology and Chronomedicine June 1-5,
2005, Antalya, Turkey. Symposium III. Chronobiology of Nutrition, Appetite Control and
Obesity. Title of Presentation: "Chronobiology of Appetite and Weight
Homeostasis."
42. Special Lecture at the Conference of International Psychosomatic Medicine, August
21-26, 2005, Kobe, Japan, Presentation title: Gene Therapy to Control
Hypothalamic Mediated Hyperphagia, Obesity and Metabolic Disorders.
12
43. Professor ML Bhatia Memorial Lecture, November 14, 2006, Department of Zoology,
University of Delhi, New Delhi, India. Presentation title: Gene therapy to combat
metabolic disorders - obesity, diabetes and cardiovascular diseases.
44. Plenary Lecture at the IBRO sponsored International Neuroscience conference on
Peptides, February 2-3, 2008, Nagpur, India. Presentation title: Gene therapy for
brain diseases.
45. Plenary Lecture at the 9th NPY Meeting, March 16-20, 2008, Okinawa, Japan.
Presentation title: Disruptions in the NPY-leptin link underlie the pandemic of
diabetes and metabolic syndrome.
46. International Symposium on Biologically Active Peptides: Peptide Diversity,
August 31-September 1, 2008, Sendai, Japan. Presentation title: Leptin-ghrelinhypothalamic crosstalk in the control of diabetes and cardiovascular diseases.
47. Showa University International Symposium for Life Science 5th Annual Meeting,
"New Frontiers in Neuroscience" September 2, 2008, Tokyo, Japan. Presentation
title: Global health benefits of central leptin gene therapy.
48. Ross University School of Medicine Symposium: "Obesity-Visible and Invisible
Spectrum of Metabolic Syndrome" May 23, 2009, Dominica. Presentation title:
Leptin insufficiency syndrome and worldwide epidemic of obesity and metabolic
diseases.
49. 14th International Congress of Endocrinology, speaker Symposium “Peptide networks
in energy metabolism”, Kyoto, Japan ,March 26-30, 2010 Presentation title: Leptin
insufficiency in the hypothalamus confers disease cluster of metabolic
syndrome: A new insight.
50. The 10th International conference on NPY-PYY-PP, Montreal, Canada, 2012 title:
Leptin-NPY link in the etiology of diabetes type 1 and 2, independent of weight
and appetite regulation.
13
HONORS (Cont.)
B. NATIONAL MEETINGS:
1.
International Society for Biochemical Endocrinology, Bar Harbor, Maine, USA, September 915, 1979. Title of presentation: "Gonadal steroids and hypothalamic monoamine
interaction in regulation of LHRH activity." Symposium on Reproductive Processes and
Contraception.
2.
Hormone Receptor Workshop, October 13-15, 1980, August, GA. Title of presentation: "The
opioid-catecholamine modulation of gonadotropin and prolactin secretion." Workshop
on Functional Correlates of Hormone Receptors in Reproduction.
3.
Workshop: "Pulsatile Sex Hormone Secretion", University of Washington, Seattle, August 1314, 1981.
4.
NIH Workshop: The Role of Proteins and Peptides in Control of Reproduction. February 1516, 1982, Washington, DC. Title of presentation: "Role of opioid peptides in control of
gonadotropin secretion."
5.
Symposium on CNS Neurotransmission and Gonadal Steroid Interactions, 33rd Ann. Mtg.
Soc. Gynec. Invest., March 20-23, 1985. Title of presentation: "Neurochemical circuits in
the control of gonadotropin secretion."
6.
NIH Workshop: "Regulation of Ovarian and Testicular Function", February 7-9, 1987,
Augusta, GA. Title of presentation: "The Neuropeptide-steroid Connection in the Control
of LHRH Secretion."
7.
Satellite Symposium of the 71st Annual Endocrine Society Meeting, "Brain-Gut Peptides and
Reproductive Hormone Secretion", Pullman, WAS, June 18-19, 1989. Title of presentation:
"Brain Endogenous Opioids and Reproduction."
8.
Society for Neuroscience Symposium on "Neuropeptide Regulation of Reproduction",
Phoenix, AZ 10/30 - 11/3/89. Title of presentation: "Neuropeptide Y-Opioid Transmission
Line to LHRH Neurons: Regulation by Gonadal Steroids."
9.
New York Academy of Sciences Conference "Central and Peripheral Significance of
Neuropeptide Y and Its Related Peptides", Baltimore, MD, April 2-4, 1990. Title of 2
Presentations:
1. "Hypothalamic NPY: A Circuit in Regulation of Neuroendocrine and Behavior
Response."
2. "Future Perspectives"
10. New York Academy of Sciences Conference "Substance P and Related Peptides: Cellular
and Molecular Physiology", Worcester, MA, July 18-21, 1991. Title of Presentation: "Effects
of Various Tachykinins on Pituitary LH Secretion, Feeding and Sexual Behavior in the
Rat."
14
11. 1st Independent Conference of the Society for the Study of Ingestive Behavior, Princeton, NJ,
June 24-28, 1992. Title of presentation: "Neuropeptide Y: Is it a physiological appetite
transducer?"
12. Symposium on Molecular and Genetic Aspects of Obesity. Pennington Biomedical Research
Center, Baton Rouge, LA, February 20-22, 1994. Title of presentation: "NPY in the Etiology
of Obesity."
13. 42nd Annual Meeting of the Society for Gynecologic Investigation, March 15-18, 1995,
Chicago, IL. Title of symposium: "Biology of Gonadotropin-positive Feedback - Role of
Peptidergic Signaling."
14. Annual meeting of the North American Association for the Study of Obesity: Baton
Rouge, LA, October 14-17, 1995. Title of presentation: "NPY and Food Intake."
15. American Physiological Society Conference: New Discoveries within the Pancreatic
Polypeptide Family: From Molecules to Medicine, November 8-11, 1995. Title of
presentation: "NPY, a Pleiotropic Neuroendocrine Signal: New Molecular and
Anatomical Considerations."
16. International Symposium on Nutrition and Reproduction, Pennington Biomedical Research
Center, October 20-22, 1996, Baton Rouge, LA. Title of Presentation "Nutritional Infertility:
Mismanagement in Central Neuropeptidergic and Peripheral Insulin-Leptin Signaling."
17. American Association for Clinical chemistry 1998 Annual Meeting and Clinical Laboratory
Exposition "Understanding Obesity and Weight Control: It's More than Just Counting
Calories", August 2-6, 1998, Chicago, IL. Title of Presentation: "Hormones, the Brain, and
the Adipocytes - Piecing It All Together".
18. Workshop "The CSF as a communication pathway in the brain." November 7, 1998, Los
Angeles, CA. Title of Presentation: "CSF as a mediator of neuroendocrine function".
19. NIH-NIDDK Symposium on "Current perspectives on hypothalamic neuropeptides in feeding
and energy regulation." June 9, 1999, Clearwater, FL. Title of Presentation: "An interacting
appetite regulating network, body weight regulation, and gene therapy".
20. The Obesity Epidemic; the Practical Approaches and Scientific Insight for Prevention and
Treatment of Obesity in Children and Adults, April 8-9, 2000, Clearwater, FL. Title of
Presentation: "Maintenance of Body Composition: The Biochemistry of Appetite Control
and Energy Expenditure".
21. Symposium on "Hypothalamus and Metabolic regulation" at the 7 th International Pituitary
Congress, Phoenix, Arizona, June 23-25, 2001. Title of Presentation: "Neuropeptides and
Appetite Control".
22. Symposium on "Genetic Approaches to an Understanding of Obesity and Eating Disorders",
The 2001 Annual Meeting of Society for Study of Ingestive Behavior, June 26-29,2001,
Philadelphia, PA. Title of Presentation: "Leptin and neurocytokine gene transfer to probe
the etiology of hypothalamus based obesity and energy expenditure".
15
23. Symposium on "Eating disorders and obesity: Are they addictive disorders?" at the American
Society of Addiction Medicine, April 25-28, 2002, Atlanta, GA. Title of Presentation: "Eating
disorders and obesity: Are they addictive disorders"?
24. Colloquium on "Control of Lifespan by Insulin/BDNF Signaling in the Nervous System", 33 rd
Annual Meeting of American Society for Neurochemistry, June 22-26, 2002, Palm Beach, FL.
Title of Presentation: "Central leptin gene therapy: a model for the study of caloric
restriction induced longevity".
25. Symposium on "Ghrelin" at the Ann. Mtg. of Experimental Biology, April 17-22, 2004
Washington, DC. Title of Presentation: "Keeping Obesity and Metabolic syndrome at bay
with central leptin and cytokine gene therapy".
26. Workshop at Annual Meeting of American Society for Reproductive Medicine. Review Control
of Gonadotropin", October 16-20, 2004, Philadelphia, PA, Title of Presentation:
"Hypothalamic interactive language controlling reproduction and energy balance".
27. Food and Addiction Meeting. Organized by Yale University's Rudd Center for Food Policy and
Obesity. July 9-10, 2007.
16
HONORS (Cont.)
C. DEPARTMENT SEMINAR SERIES:
1.
Department of Endocrinology, School of Medicine, Medical College of Georgia, Augusta, GA, October
11-12, 1976. Title of presentation: "Neuroendocrine Factors Regulating LHRH Secretion."
2.
Department of Physiology, University of California School of Medicine, San Francisco, CA, March 1113, 1980. Title of presentation: "Gonadal Steroids and LHRH."
3.
Department of Pharmacology, University of Tennessee College of medicine, Memphis, TN, October
28-29, 1980. Title of presentation: "Opioid Peptides, Catecholamines and Gonadotropin Release."
4.
Disney World 1981 Update in Obstetrics and Gynecology, Orlando, FL, February 9-11, 1981. Title of
presentation: "Neuroendocrinology of Reproduction for the Clinician."
5.
Institute of Animal Behavior, Rutgers University, Newark, NJ, April 21-22, 1981. Title of presentation:
"Gonadal Steroids, Catecholamines and Reproduction."
6.
Institute für Fierzucht und Tierverhalten, FAL, Mariensee, West Germany, May 21-22, 1981. Title of
presentation: "Opiate Regulation of LH Secretion."
7.
Instituto di Endocrinologia, Universita di Milano, Milano, Italy, May 28-29, 1981. Title of presentation:
"Mediation of Opioid Effects by Monoamines."
8.
Department of Physiology, University of Texas Southwestern Medical School, Dallas, TX, March 25,
1982. Title of presentation: "The Role of Opioid Peptides in Regulation of LH Secretion."
9.
Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, July 26,
1982. Title of presentation: "Opiate-catecholamine Interaction in Timing of Ovulation."
10.
Department of Obstetrics and Gynecology, McGill University, Montreal, Canada, July 26, 1982. Title
of presentation: "Opiate-neurotransmitter Interaction in Timing of Ovulation."
11.
Department of Obstetrics and Gynecology, Columbia University College of Physicians and
Surgeons, New York, NY, December 13, 1983. Title of presentation: "Opioid-adrenergic Steroid
Connection in the Regulation of LH Secretion in the Rat."
12.
Department of Physiology, Stanford University, CA, March 23, 1984. Title of presentation:
"Neurotransmitters in Reproduction: Facts and Fancies."
13.
Department of Physiology, Oregon Health Science University, Portland, OR, May 2-4, 1985. Title of
presentation: "Neuropeptidergic Control of LHRH Secretion."
14.
Department of Anatomy, University of Minnesota, March 4-6, 1986. Title of presentation: "Neural
Circuitry Involved in LHRH Release."
15.
Department of Biobehavioral Sciences, University of Connecticut, Storrs, October 21-23, 1986. Title
of presentation: "Neuropeptides as Signals in the Hypothalamic Control of Reproduction - New
Considerations."
16.
Laboratory of Reproductive and Development Toxicology, N.I.E.H.S., Research Triangle Park, NC,
March 10, 1987. Title of presentation: "Gonadal Steroid Feedback - A New Interpretation."
17
17.
Department of Anatomy, University of North Carolina, Chapel Hill, NC, March 11, 1987. Title of
presentation: "Steroidal Modulation of Neurosecretion."
18.
Disney World OB-Gyn Update, Orlando, FL, March 25, 1987. Title of Presentation: "Growth Hormone
and Growth Factors."
19.
Department of Biological Science, Florida State University, Tallahassee, FL, April 15-16, 1987. Title
of presentation: "Gonadal Steroid-Neuropeptide Connection in the Regulation of Reproduction."
20.
Centro de Estudios Farmacologicos y de Principios Naturales, Buenos Aires, Argentina, April 30,
1987. Title of presentation: "Gonadal Steroids and Neuropeptides in Reproduction: A Positive
Relationship."
21.
Division of Clinical Endocrinology and Metabolism, Department of Obstetrics and Gynecology,
University of Gottingen, Gottingen, Germany, May 22, 1987. Title of presentation: "Neuropeptide Y An Integrator of Reproduction and Behavior."
22.
Laboratory of Human Reproduction and Reproductive Biology, Harvard Medical School, Boston, MA,
October 9, 1987. Title of presentation: "Opiates, Neuropeptide Y and Gonadal Steroids in
Reproduction: Interactions and Diversities."
23.
Consortium for Research in Developmental and Reproductive Biology, University of Michigan, Ann
Arbor, MI, March 6, 1989. Title of presentation: "Peptidergic Wiring Between the Neural Clock and
GnRH Neurons."
24.
University of South Florida Reproductive Biology Seminar series, Tampa, FL, June 27, 1990. Title of
presentation: "Neuropeptide Y: A Novel Peptide Signal in the Control of Reproduction and
Behavior."
25.
Department of Physiology, Southern Illinois Medical School, Urbana-Champaign, IL, March 22, 1991.
Title of presentation: "The role of the neural-immune network in the control of gonadotropin
secretion and behavior."
26.
Department of Endocrinology and Physiology, University of Georgia Medical School, Augusta, GA,
April 13, 1992. Title of presentation: "Reproduction and Nutrition: Are they neurochemically
linked?"
27.
Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest
University, Winston-Salem, NC, August 21, 1992. Title of presentation: "Neuropeptide Y Reproduction, Feeding and Diabetes."
28.
Eli Lilly Research Laboratories, Indianapolis, IN, September 24, 1992. Title of presentation:
"Neuropeptide Y: A pleiotropic hypothalamic signal molecule."
29.
Bourne Laboratory, Cornell University School of Medicine, White Plains, NY. April 12, 1993. Title of
presentation: "Neuropeptide Y and other peptides in regulation of feeding."
30.
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, April
13, 1993. Title of presentation: "Reproduction and nutrition. Are they neurochemically linked?"
31.
University of Georgia Chapter of the Society for Neuroscience, Athens, GA, Grass Traveling
Scientist, October 31-November 1, 1994. Title of presentation: "Neuropeptide Y, a Pleiotropic
Neuroendocrine Signal."
18
32.
Florida State University, Tallahassee, FL, November 8-9, 1994. Department of Biology: Title of
presentation: "Neuropeptide Y and Ovulation". Department of Psychology: Title of presentation:
"Reproduction and Ingestive Behavior: Are they neurochemically linked?"
33.
Department of Biology, Boston University, Boston, MA, November 29, 1994. Title of presentation:
"Neuropeptides, Nitric Oxide and Ovulation."
34.
Department of Neuroscience, University of Florida, Gainesville, FL, January 26, 1996. Title of
presentation: "Ob and NPY genes in brain control of obesity."
35.
Eli Lilly Research Laboratories, Indianapolis, IN, April 11-12, 1996: Title of presentation: "Is NPY a
naturally-occurring appetite transducer? Implications in obesity and reproductive failure."
36.
Amgen, Inc., Denver, CO, June 26-27, 1996: Title of presentation: "NPY and Obesity."
37.
Center for Human Nutrition, University of Texas, Southwestern Medical Center, Dallas, TX, December
3-4, 1996. Title of presentation: "Appetite and Body Weight Regulation: Is It All in the Brain?"
38.
Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL, March 7,
1997. Title of presentation: "Language of the Brain: Lessons from the Hypothalamus."
39.
College of Medicine, University of Florida, MD/Ph.D. Program, Gainesville, FL, March 17, 1997. Title
of presentation: "Physiology of Appetite: Is it all in the Brain."
40.
Special Lecture, 1996 Research Award College of Medicine, University of Florida, Gainesville, FL,
April 30, 1997. Title of presentation: "Appetite (obesity): A modern or ancient scourge?"
41.
Department of Metabolic Diseases, Glaxo Wellcome, Research Triangle Park, NC. May 30, 1997.
Title of presentation: "NPY within the hypothalamic orexigenic network."
42.
Center for Drug Discovery: College of Pharmacy, University of Florida, Gainesville, FL, October 27,
1998. Title of Presentation: "Search for Appetite Regulating Drugs: Why?"
43.
Banyu Research Institute, Tsukuba, Japan, May 4, 1999. Title of presentation: "Interacting appetite
regulating signals: Role in obesity."
44.
Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, June 14, 1999.
Title of presentation: "Appetite Regulating Network: Obesity and Leptin: Where Are We?"
45.
Minority Program, Department of Physiology, University of Florida, Gainesville, FL, July 19, 1999.
Title of presentation: "Obesity."
46.
Cardiac Grand Rounds: Division of Cardiovascular Medicine, Department of Medicine, University of
Florida, Gainesville, FL, Nov. 19, 1999. Title of presentation: "Leptin: A Hormone for All Systems."
47.
Nephrology Grand Rounds: Division of Nephrology, University of Florida, Gainesville, FL, December
9, 1999. Title of presentation: "Leptin: An Obesity Hormone for All Systems."
48.
42nd Annual University of Florida - Student Science Training Program (UF-SSTP) and the NSF-Teacher
Research Update Experience (TRUE), University of Florida, College of Medicine, Gainesville, FL, July
26, 2000. Title of presentation: "Obesity, Genes, Environment and the Brain."
49.
Department of Medicine, Grand Rounds, University of Florida, College of Medicine, Gainesville, FL,
August 3, 2000. Title of presentation: "Obesity, Genes, Environment and the Brain."
19
50.
Center for Mammalian Genetics Seminars and UF Genetics Institute, University of Florida, November
13, 2000. Title of presentation: "Gene Therapy to Improve The Quality of Daily Life."
51.
32nd Symposium, Topics in Internal Medicine, Gainesville, FL, March 22, 2001. Title of presentation:
"Obesity, Genes, Environment and the Brain."
52.
National Institute of Aging, Baltimore, MD, September 13, 2002, Title of presentation "Long-term
voluntary reduction in caloric intake, adiposity and metabolic markers with central leptin gene
therapy: implication for longevity."
53.
Department of Medicine, Division of Nephrology, University of Florida, College of Medicine, Gainesville,
FL, December 31, 2002. Title of presentation, "Leptin load, obesity and longevity."
54.
Department of Animal Sciences, University of Georgia, Athens, January 23, 2004. Title of presentation
"Keeping obesity and metabolic syndrome at bay with central leptin gene therapy."
55.
College of Veterinary Medicine, University of Florida, Gainesville, March 16, 2004. Title of presentation
"Leptin, a hormone from fat cells for everybody."
56.
Department of OB/GYN, College of Medicine, University of Florida, Gainesville, Dec. 2005. Title of
presentation "Gene therapy for Obesity, Diabetes, and Fertility."
57.
Division of Nephrology, Department of Medicine, College of Medicine, University of Florida, Gainesville,
March 1, 2006. Title of presentation "Central leptin gene therapy , diabetes, and obesity: New
Insight."
58.
Division of Endocrinology, Department of Medicine, College of Medicine, University of Florida,
Gainesville, October 5,2006, "Increased leptin action in the brain can control diabetes: New
therapeutic approach."
59.
Meeting of Distinguished Professors, University of Florida, University of Florida Campus, Gainesville,
February 19, 2009. Title of presentation "Conversation between genes and environment: global
health benefits of single gene transfer into the brain."
60.
Division of Endocrinology and Metabolism, Department of Medicine, College of Medicine, University of
Florida, Gainesville, April 16, 2009. Title of presentation "Just one therapy for diabetes 1 and 2 via
two independent hypothalamic relays."
61.
Institute for Learning in Retirement (ILR), University of Florida, Gainesville, January 19, 2010. Title of
presentation "Epidemic of metabolic diseases; what's brain got to do with it."
20
HONORS (Cont.)
8. RECOGNITION FOR PUBLISHED ARTICLES: CITATION CLASSICS
1. The classic article selected for publication of the entire article for publication in the special
issue of Obesity Res 5:275-283, 1997;
Clark, J.T, Kalra, P.S, Crowley, W.R., and Kalra, P.S.
Endocrinology 117:2435, 1997.
2. Selected among the most cited papers published in 25 years of publication of "Peptides":
The abstract of the original highly cited, paper together with a review published as the 25 th
Anniversary issue, Peptides 25:465-471, 2004.
Sahu, A., Kalra, P.S. and Kalra S.P.
Peptides 121: 1953-1959, 1987.
3. As of 2/2/2004, 15th, as of 05/02/2004, 18th, and as of 08/01/2006, 16th on the list of the 50
most-frequently-cited articles in Endocrinology:
Clark, J. T., Kalra, P.S., Crowley, W.R., and Kalra S.P.
Endocrinology 115: 427-429, 1984
4. 1st among the 50 most frequently-read contents in Endocrinology during November 2002.
Bagnasco, M., Dube, M.G., Kalra, P.S. and Kalra, S.P.
Endocrinology 143: 4409-4421, 2002.
5. 11th among the 50 most frequently-read-article in "Endocrine Reviews" in August 2002, 15 th
in January 2004, 27th in March 2004, and 27th in May, 2004, 20th among the 50 mostnd
nd
st
frequently-cited articles in March 2, 2004, 22 in April 22 , 2004 and 21 in May 2004.
th
rd
and varying from 14 to 33 among the 50 most frequently-read-article, and most
frequently-cited-article as of 08/01/2006 , April 2006.
Figure 7 of this article selected for the cover of the Endocrine Reviews Issue.
Kalra, S.P., Dube, M.G., Pu, S., Xu, B., Horvath, T.L., Kalra, P.S.
Endocrine Reviews 20:68-100, 1999.
6. Highest number of "HITS" of all articles published in this issue. 2003
Kalra, S.P., and Kalra, P.S.
Regulatory Peptides 111:1-11, 2003.
7. Review article in Trends in Pharmacological Sciences 26:486-495, 2005. Selected for the
cover of this issue.
8. One of the 10 most downloaded articles in Neuropeptides for 2007.
Kalra, S.P. and Kalra, P.S.
Neuropeptides 38:201-211, 2004.
9. The 3rd most downloaded Peptides article for 2008.
Kalra, S.P.
Peptides 29:127-138, 2008.
21
10. The Top cited article 2008-1010
Kalra, S.P.
Peptides 29:127-138, 2008
22
HONORS (Cont.)
9.
SOCIETIES MEMBERSHIP:
MEMBER of the Endocrine Society, 1971 - 2005
CHARTER MEMBER of the International Society of Neuroendocrinology, 1972 - 1992
MEMBER of the American Physiological Society, 1977 - present
MEMBER of the American Association for the Advancement of Science, 1977 - present
MEMBER of the Society for Gynecologic Investigation, 1978 - 1994
MEMBER of the Society for the Study of Reproduction, 1981 - 1992
MEMBER of the American Andrology Society, 1984 - 1990
MEMBER of the Society for Neuroscience, 1984 - present
MEMBER of Society for the Study of Ingestive Behavior, 1989 - 2005
MEMBER, New York Academy of Science, 1990 - 2005
CHARTER MEMBER, American Neuroendocrine Society, 1996
MEMBER, American Society of Gene Therapy, 1999 - 2005
23
HONORS (Cont.)
10.
ORGANIZER: SCIENTIFIC MEETINGS:
Florida Neuroendocrine Society meeting, February 18, 1982
Southwest Neuroendocrine Society meeting, March 16, 1984
NIH Workshop on "Regulation of ovarian and testicular function,"
Augusta, GA, February 7-9, 1987
4th International NPY Conference, London, England, October 13-14, 1997
Symposium "Genetic approaches to an understanding of obesity and eating
Disorders" at the 2001 Annual Meeting of the Society for Study of Ingestive
Behavior, Philadelphia, June 26-30, 2001.
Member of the International Organizing Committee, Digestive Hormones,
Appetite and Energy Balance. Imperial College, London, June 30 - July 1, 2003.
Organizer, 8th International NPY Meeting, "Neuropeptide Y and Cohorts in Human
Disease", St. Petersburg, FL USA, April 22-26, 2006.
24
ADMINISTRATION AND SERVICES
III.
REVIEWER
1.
Research Committees:
National Science Foundation, 1977
March of Dimes, 1981
Sponsored Research Grant Awards, 1982
NIH Reproductive Biology Study Section (Ad Hoc), 1983-1984
NIH Reproductive Biology Study Section, 1985-1989
NIDA Drug Abuse Review Committee (Ad Hoc), 1987
Member of the National Institutes of Health Reviewers Reserve, 1989-1993
Ad hoc Reviewer for USDA and NSF awards, 1990
Division of Sponsored Research, Biomedical Research Grants, 1993-1995
Medical Research Council of Canada, 1993
International Science Foundation, Washington, 1993
Michigan Diabetes Research and Training Center, 1994
Department of Veterans Affairs Research & Development Program, CA, 1995-2002
International Human Frontier Science Program, France, 1995-present
The Welcome Trust Senior Research Fellowship in Clinical Science, UK, 1995-present
Italian Ministry Program for Funding of University Research, 1998, 1999, 2003,2004
Howard Hughes, Biomedical Research Support Advisory Committee, UF 1998-2002
NIH Reproductive Biology Study Section (ad hoc), 1996
NIMH Grant Study Section (ad hoc), 1996
NIH Site Visit, Portland, OR, 1998
NIH Reproductive Biology Study Section (ad hoc) June, 1999
NIMH Special Emphasis Study Section July, 1999
NIH Reproductive Biology Study Section (ad hoc), February, 2000
College Incentive Fund Review Committee (CIF) 2000-2003
International Scientific Advisory Committee For Joint Infrastructure Funds, The Welcome Trust,
London, England, July 2000.
National Institute on Alcohol abuse and Alcoholism special emphasis study. Panel, August 31,
2000.
NIH Biochemical Endocrinology Study Section (ad hoc) October, 2000.
Center for Scientific Review Special Emphasis Panel, February 21, 2001.
College of Medicine, UFRF Award Committee Feb. 5, 2001
Center for Scientific Review Special Emphasis Panel, on "Molecular and Neural Mechanisms
underlying the effects of Caloric restriction on Health and Longevity", April 11-13, 2001
Consultant, Council of Healthcare Advisors Gerson Lehman Group, New York, 2003- 2005
25
ADMINISTRATION AND SERVICES (cont.)
2.
JOURNALS:
Endocrinology
Neuroendocrinology
J. Neuroendocrinology
Biology of Reproduction
Life Sciences
Science
Nature
Journal for Endocrinologic Investigation
Journal of Endocrinology
Proceedings for the Society of Biology and Medicine
American Journal of Physiology, Endocrinology and Metabolism
Journal of Pharmacology and Pharmaceutics
Proceedings of the National Academy of Sciences
Journal of Gastroenterology
Physiology and Behavior
Diabetes
Clinical Endocrinology
Neuroscience
Journal of Neuroscience
Brain Research
Journal of Clinical Endocrinology and Metabolism
FEBS
Lancet
Journal of Clinical Investigation
26
ADMINISTRATION AND SERVICES (cont.)
3. COMMITTEES (NATIONAL AND INTERNATIONAL):
Member, University of Florida Senate, 1982-1984.
Award Committee, Society for the Study of Reproduction, 1985-1987; 1988-1989
Member of the Associate Professor Tenure and Promotion Committee, University of Florida
College of Medicine, 1984-1986
Chairman, Department Committee on the New Academic Wing, 1985-1986
Member, College of Medicine Grant Review Board, University of Florida, 1987 - 1988
Program Committee, Society for the Study of Reproduction, 1989-1990
Member, Program Organizing Committee, International Society of Endocrinology, Nice, 1992
Member, Bioengineering Advisory Committee, College of Medicine, University of Florida, 1994present
Member, Research Development Award Review Committee, "Biological and Life Sciences",
Division of Sponsored Research, 1994-1996
Treasurer, Faculty Council, University of Florida College of Medicine, 1994-1997
Department of Neuroscience Representative of the Faculty Council, University of Florida College of
Medicine, 1995-2000
Member, Task Force on "Diversity", University of Florida College of Medicine, 1995-1996
Member, Howard Hughes Research Resources Advisory Committee, Department of Physiology,
University of Florida College of Medicine, 1996-2002
Member, Graduate Studies Advisory Committee for the Interdisciplinary Program, 1996-present
Member, Faculty Compensation Criteria Committee, 1996
Member, Faculty Research Advisory Board, College of Medicine, 1997-2000
Member, Faculty Research Award Selection Committee for the Basic Science Faculty Research
Award, 1997
Member, Special Emphasis Panel, NIMH: Program Project, 1999
Treasurer, UF College of Medicine Faculty Council 1995 - 1998
Vice-President, UF College of Medicine Faculty Council, 1999 - 2000
College of Medicine Research Incentive Fund Study Section, 2000-2003
President-Elect - UF College of Medicine Faculty Council 2000-2001
President UF College of Medicine Faculty Council 2001-2002
Past-President UF College of Medicine Faculty Council 2002-2003
Member, University of Florida Senate 2002-2003
27
IV
TEACHING - RESEARCH TRAINING
1. TEACHING ACTIVITIES:
BMS 5020 Medical Neuroscience (medical students)
BMS 4025 Introduction to Neuroscience
DEN 6122C
Dental Neuroscience
GMS 6072 Neuroendocrinology/Neuroimmunology (Course Director)
GMS 6051 Signal Transduction
GMS 7794 Neuroscience Seminars (1997-2001)
GMS 7795 Special Topics in Neuroscience (graduate students)
2. RESEARCH TRAINING:
A.
B.
C.
Post-Graduate Fellows and Associates:
Jill Jordan, Ph.D., 1980 - 1981
Christopher Leadem, Ph.D., 1981-1983
John T. Clark, Ph.D., 1983-1986
Nicole Fournet, M.D., 1984-1985
L.Gregory Allen, Ph.D., 1984-1986
William Jacobson, Ph.D., 1986-1988
Claudio Masotto, Ph.D., 1987-1988
Abhiram Sahu, Ph.D., 1985-1989
Miguel Fuentes, M.D., 1989-1990
Klaus-Dieter Dieterich, Ph.D., 1991
Juan Bonavera, D.V.M., 1990-1994
Bin Xu, Ph.D., 1992-1998
Shuye Pu, M.D., 1994-1999
Makoto Yokosuka, Ph.D., 1996-1997
Mukul Jain, Ph.D., 1996-1999
Yuri Y. Sautin, Ph.D., 1999 -2000
Yin-Lin Ge, Ph.D., 1999-2000
Elena E. Beretta, Ph.D., 1999-2001
Michaela Bagnasco, Ph.D. 2000 - 2002
E. Edet Otukonyong, Ph.D., 2001- 2003
Anne Lecklin, Ph.D., 2001 - 2003
Naohiko Ueno, Ph.D. 2000 - 2004
Stephane Boghossian, Ph.D., 2003 - 2006
Rita Torto, Ph.D., 2004-2007
Co-Supervisor for Graduate Degree:
K.E. Estes, College of Pharmacy, 1979-1981
Steven Gabriel, College of Pharmacy, 1980-1982
Supervisory Committee for Graduate Degree:
N.R. Hall, Department of Neuroscience, 1971-1975
Dennis Kelleher, Department of Physiology, 1976-1979
MSA Kumar, Department of Reproduction, Col. of Veterinary Medicine, 1976-1979
K. Seamans, Animal Science Department, 1976-1979
R. Pardo, Department of Anatomy, 1979-1981
M. Reutter, Department of Physiology, 1994-1997
28
Brandon W. Boyd, Department of Chemistry, 1995-1999
Jonathon David Roth, Department of Psychology, 1997-1999
Rachel Marie Gentry, Department of Psychology, 1997-2000
Harveen Dhillon, Department of Physiology, 1998-2000
William E. Haskins, Department of Chemistry, 1999 - 2002
Erin K. Rhinehart, Department of Physiology, 2000 - 2003
D.
Supervisory Committee for M.S. Degree:
Dorothy M. Bradley, College of Nursing, 1980-1981
Emily Piercefield, Department of Neuroscience, 2001 - 2002
Tanya K. Murphy, Department of Psychiatry, 2001 - 2002
29
V.
1.
RESEARCH
RESEARCH INTERESTS:
NEUROENDOCRINOLOGY
NEUROIMMUNOLOGY
REPRODUCTIVE BIOLOGY
NEUROPHARMACOLOGY
OBESITY AND DIABETES
SEX BEHAVIOR
INGESTIVE BEHAVIOR
GENE THERAPY
2.
RESEARCH GRANTS:
Grant Support:
Population Council - 1971-1974.
National Institutes of Health - 1975 - 2008 (P.I. on two concurrent, independent grants,
HD08634, HD14006 or DK37273)
National Institutes of Health - 1979 - 2004 (Co.P.I. on two concurrent grants HD 11362
and NS37272).
Since 1996:
1. "Gene Therapy, Obesity and Hypothalamic Signaling", Principal Investigator (25%),
NIH DK 37273, $1,271,425, 6/01/01 - 5/31/08. (no Cost Extension)
2. "Neurotoxins, Neural Injury and Obesity", Co-investigator (20%). NIH NS37272,
Principle Investigator: Pushpa S. Kalra. $708,184, 12/1/99-11/30/04. (no cost
extension).
3. "Molecular Biology and Gene Therapy in Burns and Trauma", Co. PI and
Participating Faculty. NIH-NIGMS Training Grant. T32, GM-08721-04, Principle
Investigator: Lyle L. Moldawer. $306,233, 7/1/99-6/30/09.
4. "Brain Monomines and Luteinizing Hormone Secretion", Co-investigator (10%),
Principal Investigator: W. R. Crowley. Subcontract University of Utah, $131,860,
05/22/00 - 04/21/05. (no cost extension)
5. "Nitric Oxide, Neuropeptides and Ovulation", Principal Investigator (25%),
NIH HD 08634, $963,164, 6/1/96-8/31/04.
6. "Central Leptin Gene Therapy to Reduce Breast Cancer Risk Factors", Consultant:
Principal Investigator: Urszula Iwaniec, Department of Defense, $100,000, 2004-2005.
30
RESEARCH
3.
PUBLICATIONS
A.
REVIEWS and BOOK CHAPTERS:
1.
McCann, S.M., Kalra, P.S., Kalra, S.P., Donoso, A.O., Bishop, W., Schneider, H.P.G., Fawcett,
C.P. and Krulich, L.: The role of monoamines in the control of gonadotropin and prolactin
secretion. In: Gonadotropins. Saxena, B.E., Beling, C.G. and Gandy, H.M. (Eds.), John Wiley
and Sons, NY, pp. 49-63, 1972.
2.
McCann, S.M., Kalra, P.S., Kalra, S.P., Donoso, A.O., Bishop. W., Schneider, H.P.G., Fawcett,
C.P. and Krulich, L.: The role of monoamines in the control of gonadotropin and prolactin
secretion. In: Brain Endocrine Interactions, Median Eminence Structure and Function.
Knigge, K.M., Scott, D.E. and Weindle, A. (Eds.), S. Karger, Basel, pp. 224-235, 1972.
3.
McCann, S.M., Krulich, L., Cooper, K.J., Kalra, P.S., Kalra, S.P., Libertun, C., Negro-Vilar, A.,
Orias, R., Ronnekleiv, O. and Fawcett, C.P.: Hypothalamic control of gonadotropin and prolactin
secretion, implications for fertility control. J. Reprod. Fert., Suppl., 20:43, 1973.
4.
Kalra, S.P.: Neuroamines in gonadotropin secretion. In: Endocrinology, Vol. I, James, V.H.T.
(Ed.), Proc. 5th Internatl. Congr. Endocr., Hamburg, (Excerpta Medica, Amsterdam), pp. 152157, 1976.
5.
Kalra, S.P. and Kalra, P.S.: Central neural control of endocrine rhythms in the rat. In:
Environmental Endocrinology. Assenmacher, I. and Farner, D.S. (Eds.), Springer-Verlag, NY,
pp. 153-162, 1978.
6.
Kalra, P.S. and Kalra, S.P.: Regulation of gonadal steroid rhythms in rats. J. Ster. Biochem.,
11:981-987, 1979.
7.
Kalra, S.P., Kalra, P.S. and Simpkins, J.W.: Regulation of LHRH secretion by gonadal steroids
and catecholamines. In: Reproductive Processes and Contraception. McKerns, K.W. (Ed.),
Plenum Press, NY and London, pp. 27-45, 1981.
8.
Kalra, S.P., Simpkins, J.W. and Chen, C.L.: The opioid-catecholamine modulation of gonadotropin
and prolactin secretion. In: Functional Correlates of Hormone Receptors in Reproduction.
Mahesh, V.B., Muldoon, T., Saxena, B. and Saddler, W. (Eds.), Elsevier/North-Holland, pp. 135149, 1981.
9.
Kalra, S.P. and Kalra, P.S.: Stimulatory role of gonadal steroids on LHRH secretions. Serono
Symposium No. 49 on "Pituitary Hormones and Related Peptides". San Marino, Italy. Motta,
M., Zanisi, M. and Piva, F. (Eds.), Academic Press, NY, pp. 157-170, 1982.
10.
Kalra, S.P.: Mode of opioid and catecholamine involvement in regulating LH secretion. In:
Hormonally Active Peptides. McKerns, K.W. and Pantic, P. (Eds.), Raven Press, NY, pp. 141155, 1982.
11.
Kalra, S.P. and Kalra, P.S.: Modulation of LHRH secretion by gonadal steroids in the male rat. In:
Male Reproduction and Fertility. Negro-Vilar, A. (Ed.), Raven Press, NY, pp. 35-44, 1983.
12.
Simpkins, J.W., Estes, K.S., Kalra, P.S. and Kalra, S.P.: Alterations in hypothalamic
neurotransmitters contribute to the age-related decline in reproductive function in the male rat. In:
Male Reproduction and Fertility. Negro-Vilar, A. (Ed.), Raven Press, NY, pp. 95-109, 1983.
31
13.
Kalra, S.P.: Opioid system - inhibitory neuronal systems in regulation of gonadotropin secretion.
In: Role of Peptides and Proteins in the Control of Reproduction. McCann, S.M. and Dhindsa,
D.S. (Eds.), Elsevier Science Publishing Co., Inc., Amsterdam, pp. 63-87, 1983.
14.
Kalra, S.P. and Kalra, P.S.: Neural regulation of luteinizing hormone secretion in the rat.
Endocrine Reviews, 4:311-351, 1983.
15.
Kalra, S.P. and Leadem, C.A.: Control of luteinizing hormone secretion by endogenous opioid
peptides. In: Opioid Modulation of Endocrine Function. Delitala, G., Motta, M. and Serio, M.
(Eds.), Raven Press, NY, pp. 171-183, 1984.
16.
Kalra, S.P. and Kalra, P.S.: Hypothalamic microenvironment controlling LHRH secretion. In:
Regulation of Target Cell Responsiveness. McKerns, K.W., Aakvaag, A. and Hansson, V.
(Eds.), Plenum Press, NY, London, pp. 127-155, 1984.
17.
Kalra, S.P. and Kalra, P.S.: Opioid-adrenergic-steroid connection in regulation of LH secretion in
the rat. (Progr. in Neuroendocrinology, review) Neuroendocrinology, 38:418-426, 1984.
18.
Kalra, P.S. and Kalra, S.P.: Control of gonadotropin secretion. In: The Pituitary Gland. Imura, H.
(Ed.), Raven Press, NY, pp. 189-220, 1985.
19.
Kalra, S.P. and Kalra, P.S.: Neural circuits involved in the control of LHRH secretion: A model for
estrous cycle regulation. J. Ster. Biochem., 23:733-742, 1985.
20.
Kalra, S.P.: Neural circuitry involved in the control of LHRH secretion: A model for preovulatory
LH release. In: Frontiers in Neuroendocrinology. Martini, L. and Ganong, W.F. (Eds.), Raven
Press, NY, 9:31-75, 1986.
21.
Kalra, P.S. and Kalra, S.P.: Steroidal modulation of the regulatory neuropeptides: Luteinizing
hormone releasing hormone, neuropeptide Y and endogenous opioid peptides. J. Steroid
Biochem., 25:733-740, 1986.
22.
Kalra, S.P., Allen, L.G., Clark, J.T., Crowley, W.R. and Kalra, P.S.: Neuropeptide Y: An integrator
of reproductive and appetitive function. In: Neural and Endocrine Peptides and Receptors.
Moody, T.W. (Ed.), Plenum Press, NY, pp. 353-366, 1986.
23.
Kalra, S.P., Kalra, P.S., Sahu, A., Allen, L.G. and Crowley, W.R.: The steroid-neuropeptide Y
connection in the control of LH secretion. In: Regulation of Ovarian and Testicular Function.
Advances in Experimental Medicine and Biology, Mahesh, V.B., Dhindsa, D.S., Anderson, E. and
Kalra, S.P. (Eds.), Plenum Publishing Co., NY, 219:65-83, 1987.
24.
Kalra, S.P., Kalra, P.S., Sahu, A. and Crowley, W.R.: Gonadal steroids and neurosecretion:
Facilitatory influence on LHRH and Neuropeptide Y. J. Steroid Biochem., 27:677-681, 1987.
25.
Kalra, S.P., Allen, L.G., Sahu, A., Kalra, P.S. and Crowley, W.R.: Gonadal steroids and
neuropeptide Y-opioid-LHRH axis: Interactions and diversities. J. Steroid Biochem. 27:204-214,
1987.
26.
Kalra, S.P., Clark, J.T., Sahu, A., Dube, M.G. and Kalra, P.S.: Control of feeding and sexual
behavior by neuropeptide Y: Physiological implications. Synapse, 2:254-257, 1988.
27.
Crowley, W.R. and Kalra, S.P.: Regulation of luteinizing hormone secretion by neuropeptide Y in
rats: Hypothalamic and pituitary actions. Synapse, 2:276-281, 1988.
28.
Kalra, S.P., Clark, J.T. and Kalra, P.S.: The role of adrenergic and neuropeptidergic systems in
the regulation of male sexual behavior. In: Andrology and Human Reproduction, Negro-Vilar,
32
A., Isidori, A., Paulson, J., Abdelmassih, R. and de Castro, M.P.P. (Eds.), Serono Symposia,
Raven, Press, NY, 47:203-212, 1988.
29.
Kalra, S.P., Allen, L.G., Sahu, A., Kalra, P.S. and Crowley, W.R.: Adrenergic NPY interaction in
the hypothalamic control of LH release. In: Progress in Catecholamine Research, Part B:
Central Aspects., Alan R. Liss, Inc., Publisher, NY, pp. 239-243, 1988.
30.
Crowley, W.R. and Kalra, S.P. Regulation of preovulatory LH secretion by ovarian hormonemonoamine-neuropeptide interactions in the rat. In: Neural Control of Reproductive Function.
Lakash, J.M., Perez-Polo, J.R. and Rassin, D.K. (Eds.), Alan R. Liss, Inc., Publisher, NY, pp. 7993, 1989.
31.
Kalra, S.P., Allen, L.G. and Kalra, P.S.: Opioids in the steroid-adrenergic circuit regulating LH
secretion: Dynamics and Diversities. In: Brain Opioid Systems in Reproduction. Dyer, R.G.
and Bicknell, R.J. (Eds.), Oxford University Press, Oxford, pp. 95-111, 1989.
32.
Kalra, S.P., Clark, J.T., Sahu, A., Kalra, P.S. and Crowley, W.R.: Hypothalamic NPY: A local
circuit in the control of reproduction and behavior. In: Nobel Conference on NPY. Mutt, V., Füxe,
K., Hökfelt, T. and Lundberg, J. (Eds.), Raven Press, NY, pp. 229-241, 1989.
33.
Kalra, S.P., Sahu, A., Crowley, W.R. and Kalra, P.S.: Neuropeptidergic control of gonadotropin
secretion: Facilitation by androgens. In: Perspectives in Andrology. Serio, M. (Ed.), Serono
Symposium, Raven Press, NY, Publication 53:139-148, 1989.
34.
Kalra, S.P. and Kalra, P.S.: Do testosterone and estradiol 17β enforce inhibition or stimulation on
LHRH secretion. Biol. Reprod., 41:559-570, 1989.
35.
Kalra, S.P. and Kalra, P.S.: Neuropeptide Y - A Novel Peptidergic Signal for the Control of
Feeding Behavior. In: Current Topics in Neuroendocrinology, Pfaff, D.W. and Ganten, D.
(Eds.), Springer-Verlag, Berlin, 10:192-217, 1990.
36.
Kalra, S.P., Sahu, A. Kalra, P.S. and Crowley, W.R.: Hypothalamic NPY: A Circuit in the
Regulation of Gonadotropin Secretion and Feeding Behavior. In: Annals of the New York
Academy of Sciences, 611:273-283, 1990.
37.
Kalra, S.P. and Kalra, P.S.: Steroid-Peptide Interaction in the Endocrine Brain: Reproduction. In:
Brain Endocrinology. Motta, M. (Ed.), Raven Press, Ltd., NY, pp. 177-216, 1991.
38.
Kalra, S.P., Allen, L.G., Sahu, A. and Crowley, W.R.: Opioids and Induction of ovulation: Mediation
by Neuropeptide Y. In: Brain Gut Peptides and Reproductive Hormone Secretion. Johnston,
C.A. and Barnes, C.D. (Eds.), CRC Press, Boca Raton, FL, pp. 157-178, 1991.
39.
Kalra, S.P., Sahu, A., Dube, M.G. and Kalra, P.S.: Effects of Various Tachykinins on Pituitary LH
Secretion, Feeding and Sexual Behavior in the Rat. In: Annals of the New York Academy of
Sciences, New York, 632:332-338, 1991.
40.
Kalra, S.P. and Crowley, W.R.: Neuropeptide Y: A novel neuroendocrine peptide in the control of
pituitary hormone secretion: Emphasis on luteinizing hormone. In: Frontiers in
Neuroendocrinology, L. Martini and W.F. Ganong (eds). Plenum Press. 13:1-46, 1992.
41.
Kalra, S.P., Sahu, A. and Kalra, P.S.: Neural and Immune Network in the control of ovulation. In:
Frontiers in Reproductive Physiology. Ghosh, D. and Sengupta, J. (eds.), Wiley Eastern, Ltd.,
New Delhi, India, pp. 21-38, 1992.
42.
Kalra, S.P.: Hypothalamic Opioid Systems and Reproduction: Physiological Considerations. In:
Hormones in Gynecological Endocrinology, Parthenon Publishing, NJ, pp. 71-81, 1992.
33
43.
Kalra, P.S. and Kalra, S.P.: Immune-endocrine interactions in pituitary function. In: Hormones in
Gynecologic Endocrinology, Parthenon Publishing, NJ, pp. 321-328, 1992.
44.
Kalra, S.P., Sahu, A. and Kalra, P.S.: Ageing of the neuropeptidergic signals. J. Reprod. Fertil.,
46:11-19, 1993.
45.
Kalra, S.P.: Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormonereleasing hormone discharge. Endocrine Reviews, 14:507-538, 1993.
46.
Sahu, A., Kalra, S.P.: Neuropeptidergic regulation of feeding behavior: Neuropeptide Y. Trends
in Endocr. Metab. 4:217-224, 1993.
47.
Kalra, P.S. and Kalra, S.P.: In vivo and in vitro models for evaluating the effects of interleukin-1
on the hypothalamic-pituitary-gonadal axis. In: Neurobiology of Cytokines. Methods in
Neurosciences, Errol B. DeSouza (ed.), Academic Press, Orlando, 16:248-268, 1993.
48.
Kalra, S.P. and Kalra, P.S.: Regulation of gonadotropin secretion: Emerging new concepts. In:
The Pituitary Gland, 2nd Edition. Imura, H. (ed.), Raven Press, NY, pp. 285-308, 1994.
49.
Crowley, W.R., Parker, S.L., Sahu, A. and Kalra, S.P.: Interacting transmembrane signals
regulating GnRH and LH secretion. In: The Neurobiology of Puberty. Plant, T.M. and Lee, P.A.
(eds.), Journal of Endocrinology, Ltd., Bourne Press, UK, pp. 41-54, 1995.
50.
Kalra, S.P., Sahu, A., Dube, M.G., Bonavera, J.J. and Kalra, P.S.: Neuropeptide Y and its neural
connections in the etiology of obesity and associated neuroendocrine and behavioral disorders.
In: Molecular and Genetic Aspects of Obesity. Bray, G.A. and Ryan, D.H. (Eds). Louisiana
State University Press, Baton Rouge, LA, 5:219-232, 1996.
51.
Kalra, S.P. Gonadal steroids promote interactive communication. In: The Brain: Source and
Target for Sex Steroids Hormones. Genazzani, R., Petraglia, F. And Purdy, R.H. (Eds),
Parthenon Publishing, Lancaster, UK, pp. 153-169, 1996.
52.
Kalra, S.P. and Kalra, P.S.: Is neuropeptide Y (NPY) a naturally-occurring appetite transducer?
In: Current Opinions in Endocrinology and Diabetes. Kohler, P.O. (ed.), Smith, S.M. (Section
Ed.), Current Science, 3:157-163, 1996.
53.
Kalra, S.P. and Kalra, P.S.: Nutritional Infertility: The role of the interconnected hypothalamic
neuropeptide Y - galanin - opioid network. In: Frontiers in Neuroendocrinology. L. Martini and
W.F. Ganong (Eds.), 17:371-401, 1996.
54.
Kalra, S.P. and Kalra, P.S.: Interactive hypothalamic neural circuitry in the control of reproduction:
New Emerging Concepts. In: Neural Aspects of Reproduction: Physiology and Behavior.
Maeda, K-I, Tsukamura, H. and Yokoyama, A. (Eds.), S. Karger, Tokyo, pp. 3-16, 1997.
55.
Kalra, S.P., Horvath, T., Naftolin, F., Xu, G., Pu, S. and Kalra, P.S.: The Interactive Language of
the Hypothalamus for the GnRH System. J. Neuroendocr. 9:569-576, 1997.
56.
Kalra, S.P.: Appetite and body weight regulation; is it all in the brain? Neuron, 19:227-230, 1997.
57.
Rowland, N.E. and Kalra, S.P.: Potential role of neuropeptide ligands in the treatment of obesity.
CNS Drugs 6:419-426, 1997.
58.
Kalra, P.S., Edwards, T.G., Xu, B., Jain, M., and Kalra, S.P.: The anti-gonadotropic effects of
cytokines: Role of neuropeptides. Domestic Animal Endocrinology 15:321-332, 1998.
34
59.
*** 60.
Kalra, S.P., Xu, B., Dube, M.G. and Kalra, P.S.: Nutritional Infertility: Mismanagement in central
neuropeptidergic and peripheral insulin-leptin signaling. In: Nutrition and Reproduction. W.
Hansel, G.A. Bray, and D.H. Ryan, eds. Louisiana State University Press, Baton Rouge, pp. 2540, 1998.
Kalra, S.P., Dube, M.G., Pu, S. and Kalra, P.S.: Interactive appetite regulating pathways in the
hypothalamic regulation of body weight. Endocrine Rev. 20:68-100, 1999
61.
Kalra, S.P. and Horvath, T.L.: Neuroendocrine interactions between galanin, opioids, and
neuropeptide Y in the control of reproduction and appetite. In: Galanin: Basic Research
Discoveries and Therapeutic Implications. T. Hökfelt, T. Bartfei, and J. Crawley, eds. Ann NY
Acad Sci 863:236-240, 1999.
62.
Kalra, P.S., Dube, M.G., and Kalra, S.P.: Effects of centrally administered antisense
oligodeoxynucleotides on feeding behavior and hormone secretion. Methods in Enzymology.
314:184-200, 2000.
63.
Kalra, P.S., and Kalra, S.P.: Design and use of NPY antisense oligodeoxynucleotides to study the
actions of NPY. In: Methods in Molecular Biology: Neuropeptide Y Protocols. A.
Balasubramaniam, Ed. Humana Press, Totowa, New Jersey, pp. 151-16, 2000.
64.
Kalra, S.P., Pu, S., Horvath, T.L, and Kalra P.S.: Leptin and NPY regulation of GnRH secretion and
energy homeostasis. In The onset of Puberty in Prospective, Bourguignon J.P. and Plant, T.M.
(Eds), Elsevier, Amsterdam, pp. 317-327, 2000.
65.
Kalra, P.S., and Kalra, S.P.: Use of antisense oligonucleotides to study the physiological functions of
Neruropeptide Y. Methods 22:249-254, 2000.
66.
Kalra, S.P., Circumventing leptin resistance for weight control. Proc. Natl. Acad. Sci., 98:42794281, 2001
67.
Kalra, S.P. and Kalra, P.S., Viral vectors as probes to decipher brain circuitry for weight control.
Trends in Endocr. & Metab., 12:377-378, 2001
68.
Kalra, P.S. and Kalra, S.P.: Obesity and Metabolic Syndrome: Long term benefits of central leptin
gene therapy. Drugs of today. 2002 38:745-757.
69.
Kalra, S. P. and Kalra, P.S., Gene therapy for appetite and body weight regulation: All in the brain.
Menopause, The state of the Art in research and management. HPG Schneider (ed), The
Parthenon Publishing Group, 2003 pp265-270.
70.
Kalra, S.P. and Kalra, P.S. Rhythmic, reciprocal ghrelin and leptin signaling in the hypothalamic
control of energy balance: implication in obesity. Regulatory Peptides 111:1-11, 2003
*** See Recognition of Published Articles (Citation Classic) #5, page 20
35
71.
Kalra, S.P. and Kalra P.S.: Neuropeptide Y. In: Encyclopedia of Hormones, Kelly, M. and Norman,
A. W. (eds) Academic Press 2003 3:37-45.
72.
Kalra, S. P. Neuropeptide Y: a physiological orexigen modulation by the feedback action of ghrelin
and leptin. Endocrine 22:49-56, 2003.
73.
Kalra, S.P. and Kalra, P.S.: Keeping obesity and metabolic syndrome at bay with central leptin and
cytokine gene therapy. Current Medicinal Chemistry - Central Nervous System Agent. Benthem
Science Publications Ltd., 3:189-199, 2003.
74.
Kalra S.P. and Kalra P.S. NPY: a novel on/off switch for control of appetite and reproduction. In:
Handbook of Experimental Pharmacology. Springer -Verlang, Amsterdam, 221-249, 2004.
75.
Kalra, S.P. and Kalra, P.S.: Overlapping and interactive pathways regulating appetite and craving. J.
Addictive Diseases (Special Issue) 23:5-21, 2004.
76.
Kalra, S.P. and Kalra, P.S.: Hypothalamic Regulation of Appetite and Metabolism. Encyclopedia of
Endocrinology and Endocrine Diseases, Martini, L. (ed) Academic Press, Vol. 2: 699-706, 2004.
§ 77.
Kalra, S.P. and Kalra, P.S.: NPY- an endearing journey in search of a neurochemical on/off switch for
appetite, sex and reproduction. Twenty-Five years of Peptides, Kastin, AJ (ed), Peptides 25:465471, 2004.
§ 78.
Kalra, S.P. and Kalra P.S.: NPY and Cohorts in appetite, obesity and metabolic syndrome. Gehlert,
DR and Crawley, J (eds) Special Issue Neuropeptides, 38:201-211, 2004.
79.
Kalra, S.P. and Kalra P.S.: Subjugation of hypothalamic NPY and cohorts with central leptin gene
therapy alleviates dyslipidemia, insulin resistance, and obesity for life-time. In: NPY Family of
Peptides in Neurobiology, Cardiovascular and Metabolic disorders: Genes, Functions and
Therapeutics. Zukowska, Z and Feuerstein, G (eds). Birkhauser Verlag Publishing House,
Switzerland, 157-169, 2005.
80.
Kalra, S.P. and Kalra P.S.: Gene Transfer Technology: a preventive neurotherapy to curb obesity,
ameliorate metabolic syndrome and extend life-expectancy. Trends in Pharmacological Sciences,
26:488-495, 2005.
81.
Kalra, S.P. and Kalra P.S.: Neuropeptide Y: A conductor of the appetite regulating orchestra in the
hypothalamus:, In: Handbook of Biologically Active Peptides. Abba Kastin (ed), Elsevier Press,
Amsterdam, pp 889-894, 2006.
82.
Kalra, S.P. and Kalra, P.S.: To subjugate NPY is to improve the quality of life and live longer.
Peptides 28:413-418, 2007.
83.
Kalra, S.P.: Global life-long health benefits of repression of hypothalamic NPY system by central
leptin gene therapy. Current Topics in Medicinal Chemistry 7:1675-1681 2007.
§ 84.
85.
86.
Kalra, S.P.: Central leptin insufficiency syndrome: An interactive etiology for obesity, metabolic and
neural diseases and for designing new therapeutic interventions. Peptides 29:127-38, 2008.
Kalra, S.P.: Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic
syndrome: new therapeutic approaches. Nutrition 24:820-6, 2008.
Kalra, S.P.: Increased leptin supply to hypothalamus by gene therapy confers life-long benefits on
energy homeostasis, disease cluster of metabolic syndrome-diabetes type 1 and 2, dyslipidemia and
cardiovascular ailments-and bone remodeling. In: Transmitters and Modulators in Health and
36
Disease. Shioda, S, Homma, I and Kato, N (eds). Springer,Tokyo, 19-30, 2009.
87.
Kalra, S.P.: Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent
hypothalamic relays; a benefit beyond weight and appetite regulation. Peptides 30:1957-63, 2009.
88.
Kalra, S.P.: Leptin gene therapy for hyperphagia, obesity, metabolic diseases and addiction; a new
opportunity. In: Handbook of Food and Addiction. Brownell, K and Gold, M (eds).Oxford University
Press. in press, 2010.
89.
Kalra, S.P. and Kalra, P.S.: Neuroendocrine control of energy homeostasis: update on new insights.
In: Progress in Brain Research, Vol. 181:17-31, 2010 . Martini, L (ed).
90.
Kalra, S.P.: Pivotal role of leptin –hypothalamus signaling in the etiology of diabetes uncovered by
gene therapy: a new therapeutic intervention? Gene Therapy, 18:319-329, 2011
$ See recognition for Published Articles, (Citation Classic), #2, page 20
37
RESEARCH (cont.)
PUBLICATIONS (cont.)
B.
REFEREED PUBLICATIONS:
1.
Prasad, M.R.N., Kalra, S.P. and Segal, S.J.: Effects of clomiphene on blastocysts during delayed
implantation in the rat. Fertil. Steril., 16:101-105, 1965.
2.
Prasad, M.R.N. and Kalra, S.P.: Mechanism of anti-implantation action of clomiphene. J. Reprod.
Fertil., 13:59-66, 1967.
3.
Kalra, S.P. and Prasad, M.R.N.: Effect of clomiphene on fertility in female rats. Ind. J. Exp. Biol.,
5:1-8, 1967.
4.
Kalra, S.P. and Prasad, M.R.N.: Effect of clomiphene on fertility in male rats. J. Reprod. Fertil.,
14:39-48, 1967.
5.
Kalra, S.P. and Prasad, M.R.N.: Effects of FSH and testosterone propionate on spermatogenesis
in immature rats treated with clomiphene. Endocrinology, 81:965-975, 1967.
6.
Kalra, S.P. and Prasad, M.R.N.: Pattern of recovery of pituitary gonadotropins in intact male rats
following long-term treatment with estrogen. Fertil. Steril., 20:258-266, 1969.
7.
Kalra, S.P. and Prasad, M.R.N.: Recovery of spermatogenic and androgenic activity in adult male
rats following long-term treatment with estrogen. Fertil. Steril., 20:495-505, 1969.
8.
Kalra, S.P., Velasco, M.E. and Sawyer, C.H.: Influences of hypothalamic deafferentation on
pituitary FSH release and estrogen feedback in immature female parabiotic rats.
Neuroendocrinology, 7:228-235, 1970.
9.
Kalra, S.P. and Sawyer, C.H.: Blockade of copulation-induced ovulation in the rat by anterior
hypothalamic deafferentation. Endocrinology, 87:1124-1128, 1970.
10.
Kalra, S.P., Ajika, K., Krulich, L., Fawcett, C.P., Quijada, M. and McCann, S.M.: Effects of
hypothalamic and preoptic electrochemical stimulation on gonadotropin and prolactin release in
proestrus rats. Endocrinology, 88:1150-1158, 1971.
11.
Kalra, P.S., Kalra, S.P., Krulich, L., Fawcett, C.P. and McCann, S.M.: Involvement of
norepinephrine in transmission of the stimulatory influence of progesterone on gonadotropin
release. Endocrinology, 90:1168-1176, 1972.
12.
Gallo, R.V., Johnson, J.H., Kalra, S.P., Whitmoyer, D.I. and Sawyer, C.H.: Effects of luteinizing
hormone on multiple unit activity in rat hypothalamus. Neuroendocrinology, 9:149-157, 1972.
13.
Kalra, S.P. and McCann, S.M.: Effects of drugs modifying catecholamine synthesis on LH release
induced by preoptic stimulation in the rat. Endocrinology, 93:356-362, 1973.
14.
Kalra, S.P. and McCann, S.M.: Variations in the release of LH in response to electrochemical
stimulation of preoptic area and medial basal hypothalamus during the estrous cycle of the rat.
Endocrinology, 93:665-669, 1973.
15.
Kalra, S.P., Krulich, L. and McCann, S.M.: Changes in gonadotropin-releasing factor content in the
rat hypothalamus following electrochemical stimulation of anterior hypothalamic area and during
the estrous cycle. Neuroendocrinology, 12:321-333, 1973.
38
16.
Kalra, S.P. and McCann, S.M.: Effects of drugs modifying catecholamine synthesis on plasma LH
and ovulation in the rat. Neuroendocrinology, 15:79-91, 1974.
17.
Kalra, S.P. and Kalra, P.S.: Effects of circulating estradiol during rat estrous cycle on LH release
following electrochemical stimulation of preoptic brain or administration of synthetic LRF.
Endocrinology, 94:845-851, 1974.
18.
Kalra, S.P.: Role of estrogen in the restoration of LH release following stimulation of partially
deafferented hypothalamus in rats. Brain Res., 68:297-307, 1974.
19.
Kalra, S.P. and Kalra, P.S.: Temporal interrelationships between the circulating levels of estradiol,
progesterone and LH during the rat estrous cycle: Effects of exogenous progesterone.
Endocrinology, 95:1711-1718, 1974.
20.
Kalra, S.P.: Observations on facilitation of the preovulatory rise of LH by estrogen. Endocrinology,
96:23-28, 1975.
21.
Kalra, S.P.: Studies on the site(s) of blockade by Actinomycin-D of estrogen-induced LH release.
Neuroendocrinology, 18:333-344, 1975.
22.
Kalra, S.P.: Circadian rhythm in luteinizing hormone-releasing hormone (LH-RH) content of
preoptic area during the rat estrous cycle. Brain Res., 104:354-358, 1976.
23.
Kalra, S.P.: Tissue levels of luteinizing hormone-releasing hormone in the preoptic area and
hypothalamus and serum concentrations of gonadotropins following anterior hypothalamic
deafferentation and estrogen treatment of the female rat. Endocrinology, 99:101-107, 1976.
24.
Kalra, S.P.: Ovarian steroids differentially augment pituitary FSH release in deafferented rats.
Brain Res., 114:541-544, 1976.
25.
Kalra, S.P., Kalra, P.S. and Mitchell, E.O.: Differential response of luteinizing hormone-releasing
hormone in the basal hypothalamus and the preoptic area following anterior hypothalamic
deafferentation and/or castration in male rats. Endocrinology, 100:201-204, 1977.
26.
Kalra, S.P.: Suppression of serum LH-RH and LH in rats by an inhibitor of norepinephrine
synthesis. J. Reprod. Fertil., 49:371-373, 1977.
27.
Kalra, P.S. and Kalra, S.P.: Temporal changes in the hypothalamic and serum luteinizing
hormone-releasing hormone (LH-RH) levels and the circulating ovarian steroids during the rat
estrous cycle. Acta Endocr., 85:449-455, 1977
28.
Kalra, P.S. and Kalra, S.P.: Circadian periodicities of serum androgens, progesterone,
gonadotropins and LHRH in male rats: The effect of hypothalamic deafferentation, castration or
adrenalectomy. Endocrinology, 101:1821-1827, 1977.
29.
Kalra, S.P.: Effect of estrogen on 3H-leucine uptake by the hypothalamus and pituitary: Correlation
with hypothalamic and serum LH-RH and LH. J. Endocr. Invest., 2:131-135, 1978.
30.
Kalra, P.S. and Kalra, S.P.: Effects of intrahypothalamic testosterone implants on LHRH levels in
the preoptic area and the medial basal hypothalamus. Life Sci., 23:65-68, 1978.
31.
Kalra, S.P., Kalra, P.S., Chen, C.L. and Clemens, J.S.: Effect of norepinephrine synthesis
inhibitors and a dopamine agonist on hypothalamic LHRH, serum gonadotropin and prolactin
levels in gonadal steroid treated rats. Acta Endocr., 89:1-9, 1978.
32.
Strauss, S.S., Chen, C.L., Kalra, S.P. and Sharp, D.C.: Localization of gonadotropin-releasing
39
hormone (GnRH) in the hypothalamus of ovariectomized pony mares by season. J. Reprod. Fert.,
Suppl., 27:123-129, 1979.
33.
Simpkins, J.W. and Kalra, S.P.: Blockade of progesterone-induced increase in hypothalamic
luteinizing hormone-releasing hormone levels and serum gonadotropins by intrahypothalamic
implants of 6-hydroxydopamine. Brain Res., 170:475-484, 1979.
34.
Kalra, S.P. and Kalra, P.S.: Dynamic changes in hypothalamic LH-RH levels associated with the
ovarian steroid-induced gonadotrophin surge. Acta Endocr., 92:1-7, 1979.
35.
Cook, P.S., Notelovitz, M., Kalra, P.S. and Kalra, S.P.: Effect of Diazepam on serum testosterone
and the ventral prostate gland in male rats. Arch. Androl., 3:31-35, 1979.
36.
Kalra, P.S. and Kalra, S.P.: Modulation of hypothalamic luteinizing hormone-releasing hormone
levels by intracranial and subcutaneous implants of gonadal steroids in castrated rats: Effects of
androgen and estrogen antagonists. Endocrinology, 106:390-397, 1980.
37.
Simpkins, J.W., Kalra, P.S. and Kalra, S.P.: Effects of testosterone on catecholamine turnover and
LHRH contents in the basal hypothalamus and preoptic area. Neuroendocrinology, 30:94-100,
1980.
38.
Kalra, P.S. and Kalra, S.P.: Progesterone stimulates testosterone secretion in male rats.
Neuroendocrinology, 30:183-187, 1980.
39.
Simpkins, J.W., Kalra, P.S. and Kalra, S.P.: Inhibitory effects of androgens on preoptic area
dopaminergic neurons in castrate rats. Neuroendocrinology, 31:177-181, 1980.
40.
Simpkins, J.W., Kalra, P.S. and Kalra, S.P.: Temporal alterations in luteinizing hormone releasing
hormone concentrations in several discrete brain nuclei: Effects of estrogen-progesterone and
norepinephrine synthesis inhibition. Endocrinology, 107:573-577, 1980.
41.
Kumar, M.S.A., Chen, C.L. and Kalra, S.P.: Distribution of luteinizing hormone releasing hormone
in the canine hypothalamus: Effect of castration and exogenous gonadal steroids. Am. J. Vet.
Res., 41:1304-1309, 1980.
42.
Kalra, S.P., Simpkins, J.W. and Kalra, P.S.: Effects of pentobarbital on hypothalamic
catecholamines and LHRH activities. Acta Endocr., 95:1-6, 1980.
43.
Kalra, S.P. and Kalra, P.S.: A dopamine agonist stimulates progesterone secretion from adrenal
gland. Life Sci., 18:1467-1469, 1981.
44.
Kalra, S.P., Simpkins, J.W. and Kalra, P.S.: Progesterone-induced changes in hypothalamic
LHRH and catecholamines: Differential effects of pentobarbital. Endocrinology, 108:1299-1304,
1981.
45.
Simpkins, J.W., Kalra, P.S. and Kalra, S.P.: Alterations in daily rhythms of testosterone and
progesterone in old male rats. Exp. Aging Res., 7:25-32, 1981.
Kalra, S.P., Chen, C.L. and Kumar, M.S.A.: Differential response of methionine-enkephalin in
basal hypothalamus and preoptic area following hypothalamic deafferentation. Brain Res.,
215:410-413, 1981.
46.
47.
Kalra, P.S., Simpkins, J.W. and Kalra, S.P.: Hyperprolactinemia counteracts the testosteroneinduced inhibition of preoptic dopamine turnover. Neuroendocrinology. 33:118-122, 1981.
48.
Kalra, S.P. and Simpkins, J.W.: Evidence for noradrenergic mediation of opioid effects on LH
secretion. Endocrinology, 109:776-782, 1981.
40
*
49.
Kalra, P.S. and Kalra, S.P.: Differential effects of low serum levels of estradiol-17β on
hypothalamic LHRH levels and LH secretion in castrated male rats. Neuroendocrinology, 33:340346, 1981.
50.
Kalra, S.P.: Neural loci involved in naloxone-induced LH release: Effects of a norepinephrine
synthesis inhibitor. Endocrinology, 109:1805-1810, 1981.
51.
Estes, K.S., Simpkins, J.W. and Kalra, S.P.: Resumption with clonidine of pulsatile LH release
following acute norepinephrine depletion in ovariectomized rats. Neuroendocrinology, 35:56-62,
1982.
52.
Simpkins, J.W., Hodson, C.A., Kalra, P.S. and Kalra, S.P.: Chronic hyperprolactinemia depletes
hypothalamic dopamine concentrations in male rats. Life Sci., 30:1349-1353, 1982.
53.
Kalra, P.S. and Kalra, S.P.: Discriminative effects of testosterone on the hypothalamic luteinizing
hormone releasing hormone (LHRH) levels and LH secretion in castrated male rats: Analyses of
dose and duration characteristics. Endocrinology, 111:24-29, 1982.
54.
Kumar, M.S.A., Chen, C.L., Sharp, D.C., Liu, J.M., Kalra, P.S. and Kalra, S.P.: Diurnal
fluctuations in methionine-enkephalin levels in the hypothalamus and preoptic area of male rat:
Effects of pinealectomy. Neuroendocrinology, 35:28-31, 1982.
55.
Kalra, S.P. and Crowley, W.R.: Epinephrine synthesis inhibitors block naloxone-induced LH
release. Endocrinology, 111:1403-1405, 1982.
56.
Estes, K.S., Simpkins, J.W. and Kalra, S.P.: Normal LHRH neuronal function and
hyperprolactinemia in old pseudopregnant Fischer 344 rats. Neurobiol. Aging, 3:247-252, 1982.
57.
Simpkins, J.W., Kalra, S.P. and Kalra, P.S.: Variable effects of testosterone on dopamine activity
in several microdissected regions in the preoptic area and medial basal hypothalamus.
Endocrinology, 112:665-669, 1983.
58.
Kalra, P.S., Simpkins, J.W., Luttge, W.G. and Kalra, S.P.: Effects on male sex behavior and
preoptic dopamine neurons of hyperprolactinemia induced by MtTW15 pituitary tumors.
Endocrinology, 113:2065-2071, 1983.
59.
Kalra, S.P. and Gallo, R.V.: Effects of intraventricular administration of catecholamines on
luteinizing hormone release in morphine-treated rats. Endocrinology, 113:23-28, 1983.
60.
Gabriel, S.M., Simpkins, J.W. and Kalra, S.P.: Modulation of endogenous opioid influence on
luteinizing hormone secretion by progesterone and estrogen. Endocrinology, 113:1806-1811,
1983.
61.
Leadem, C.A. and Kalra, S.P.: Stimulation with estrogen and progesterone of luteinizing hormone
(LH)-releasing hormone release from perifused adult female rat hypothalami: Correlation with the
LH surge. Endocrinology, 114:51-56, 1984.
62.
Kalra, P.S., Simpkins, J.W. and Kalra, S.P.: Testosterone raises LHRH levels exclusively in the
median-eminence of castrated rats. Neuroendocrinology, 39:45-48, 1984.
63.
64.
Clark, J.T., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Neuropeptide Y and human pancreatic
polypeptide stimulate feeding behavior in rats. Endocrinology, 115:427-429, 1984.
Kalra, S.P. and Crowley, W.R.: Norepinephrine-like effects of neuropeptide Y on LH release in the
rat. Life Sci., 35:1173-1176, 1984.
41
65.
Kalra, S.P. and Crowley, W.R.: Differential effects of pancreatic polypeptide on luteinizing
hormone release in female rats. Neuroendocrinology, 38:511-513, 1984.
66.
Gabriel, S.M., Simpkins, J.W., Kalra, S.P. and Kalra, P.S.: Chronic morphine treatment induces
hypersensitivity to testosterone negative feedback in castrated male rats. Neuroendocrinology,
40:39-44, 1985.
67.
Kalra, S.P.: Catecholamine involvement in preovulatory LH release: Reassessment of the role of
epinephrine. Neuroendocrinology, 40:139-144, 1985.
68.
Leadem, C.A., Crowley, W.R., Simpkins, J.W. and Kalra, S.P.: Effects of naloxone on
catecholamine and LHRH release from the perifused hypothalamus of the steroid-primed rat.
Neuroendocrinology, 40:497-500, 1985.
69.
Leadem, C.A. and Kalra, S.P.: Reversal of βE-induced blockade of ovulation and LH surge with
PGE2. Endocrinology, 117:684-689, 1985.
70.
Allen, L.G., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Comparison of the effects of Neuropeptide
Y and adrenergic transmitters on LH release and food intake in male rats. Life Sci., 37:617-623,
1985.
71.
Leadem, C.A. and Kalra, S.P.: The effects of endogenous opioid peptides and opiates on
luteinizing hormone and prolactin secretion in ovariectomized rats. Neuroendocrinology, 41:342352, 1985.
** 72.
Clark, J.T., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Neuropeptide Y stimulates feeding but
inhibits sexual behavior in rats. Endocrinology, 117:2435-2442, 1985.
73.
Crowley, W.R., Tessel, R.E., O'Donohue, T.L., Adler, B.A. and Kalra, S.P.: Effects of ovarian
hormones on the concentrations of immunoreactive neuropeptide Y in discrete brain regions of the
female rat: Correlation with serum LH and median eminence LHRH. Endocrinology, 117:11511155, 1985.
74.
Allen, L.G. and Kalra, S.P.: Evidence that a decrease in opioid tone may evoke preovulatory
luteinizing hormone release in the rat. Endocrinology, 118:2375-2381, 1986.
75.
Gabriel, S.M., Berglund, L.A., Kalra, S.P., Kalra, P.S. and Simpkins, J.W.: The influence of chronic
morphine treatment on the negative feedback regulation of gonadotropin secretion by gonadal
steroids. Endocrinology, 119:2762-2767, 1986.
* See Recognition for Published Articles, (Citation Classic), #3, page 20
** See Recognition for Published Articles (Citation Classic), #1, page 20
78.
Clark, J.T., Simpkins, J.W. and Kalra, S.P.: Long-term weekly gonadal steroid treatment: Effects
on plasma prolactin, sexual behavior and hypothalamic-preoptic area catecholamines.
Neuroendocrinology, 44:488-493, 1987.
77.
Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Differential in vitro stimulation by naloxone of LHRH
and catecholamine release from the hypothalami of intact and castrated rats. Endocrinology,
120:178-185, 1987.
78.
Crowley, W.R., Hassid, A. and Kalra, S.P.: Neuropeptide Y enhances the release of luteinizing
hormone induced by luteinizing hormone-releasing hormone. Endocrinology, 120:941-945, 1987.
79.
Clark, J.T., Sahu, A., Kalra, P.S., Balasubramaniam, A. and Kalra, S.P.: Neuropeptide Y (NPY)42
induced feeding behavior in female rats: Comparison with human NPY (Methionine -17-NPY), NPY
analog (Norleucine4-NPY) and Peptide YY. Reg. Peptides, 17:31-39, 1987.
'
80.
Sahu, A. and Kalra, S.P.: Delta sleep-inducing peptide (DSIP) stimulates LH release in steroidprimed ovariectomized rats. Life Sci., 40:1201-1206, 1987.
81.
Sahu, A., Kalra, S.P., Crowley, W.R., O'Donohue, T.L. and Kalra, P.S.: Neuropeptide Y levels in
microdissected regions of the hypothalamus and in vitro release in response to KCl and
Prostaglandin E2: Effects of castration. Endocrinology, 120:1831-1836, ,1987.
82.
Kalra, P.S. and Kalra, S.P.: The effect of hyperprolactinemia produced by transplantable pituitary
MtTW15 tumors cells in male rats on hypothalamic LHRH release in vitro: Effects of naloxone and
K+. Endocrinology, 121:310-315, 1987.
83.
Crowley, W.R. and Kalra, S.P.: Neuropeptide Y stimulates the release of luteinizing hormonereleasing hormone from medial basal hypothalamus in vitro: Modulation by ovarian hormones.
Neuroendocrinology, 46:97-103, 1987.
84.
Clark, J.T., Kalra, S.P. and Kalra, P.S.: Effects of a selective α1-adrenoreceptor agonists,
Methoxamine, on sexual behavior and penile reflexes. Physiol. Behav., 40:747-753, 1987.
85.
Sahu, A., Crowley, W.R., Tatemoto, K., Balasubramaniam, A. and Kalra, S.P.: Effects of
neuropeptide Y, NPY analog (Norleucine 4-NPY), Galanin and neuropeptide K on LH release in
ovariectomized (ovx) and ovx estrogen, progesterone-treated rats. Peptides, 8:921-926, 1987.
86.
Allen, L.G., Crowley, W.R. and Kalra, S.P.: Interactions between neuropeptide Y and adrenergic
systems in stimulation of LH release in steroid-primed ovariectomized rats. Endocrinology,
121:1953-1959, 1987.
87.
88.
Sahu, A., Kalra, P.S. and Kalra, S.P.: Food deprivation and ingestion induce reciprocal changes in
neuropeptide Y concentrations in the paraventricular nucleus. Peptides, 9:83-86, 1988.
Kalra, P.S., Sahu, A. and Kalra, S.P.: Opiate-induced hypersensitivity to testosterone feedback:
Pituitary involvement. Endocrinology, 122:997-1003, 1988.
' See Recognition of Published Articles (citation classic), #2, page 20
89.
Allen, L.G., Hahn, E., Caton, D. and Kalra, S.P.: Evidence that a decrease in opioid tone on
proestrus changes the episodic pattern of LH secretion: Implications in the preovulatory LH
hypersecretion. Endocrinology, 122:1004-1013, 1988.
90.
Sahu, A., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Evidence that hypothalamic neuropeptide Y
secretion decreases in aged male rats: Implications for reproductive aging. Endocrinology,
125:2199-2203,1988.
91.
Gabriel, S.M., Clark, J.T., Kalra, P.S., Kalra, S.P. and Simpkins, J.W.: Chronic morphine and
testosterone treatment: Effects of norepinephrine and serotonin metabolism and gonadotropin
secretion in male rats. Brain Res., 447:200-203, 1988.
92.
Clark, J.T., Gabriel, S.M., Simpkins, J.W., Kalra, S.P. and Kalra, P.S.: Chronic morphine and
testosterone treatment: Effects of sexual behavior and dopamine metabolism in male rats.
Neuroendocrinology, 48:97-104, 1988.
43
93.
Sahu, S., Kalra, S.P., Crowley, W.R. and Kalra, P.S.: Evidence that neuropeptide Y-containing
neurons in the brain stem project into selected hypothalamic nuclei. Brain Res., 457:376-378,
1988.
94.
Clark, J.T., Gist, R.S., Kalra, S.P. and Kalra, P.S.: α2-adrenoceptor blockade attenuates feeding
behavior induced by Neuropeptide Y and epinephrine. Phys. Behav., 43:417-422, 1988.
95.
Sahu, A., Kalra, P.S., Dube, M.G. and Kalra, S.P.: Neuropeptide K suppresses feeding in the rat.
Reg. Peptides, 23:135-143, 1988.
96.
Kalra, S.P., Dube, M.G. and Kalra, P.S.: Continuous intraventricular infusion of neuropeptide Y
evokes episodic food intake in satiated female rats: Effects of adrenalectomy and cholecystokinin.
Peptides, 9:723-728, 1988.
97.
Jacobson, W. and Kalra, S.P.: Decreases in mediobasal hypothalamic and preoptic area opioid
(3H naloxone) binding are associated with the progesterone-induced LH surge. Endocrinology,
124:199-205, 1989.
98.
Sahu, A., Kalra, S.P., Crowley, W.R. and Kalra, P.S.: Testosterone raises neuropeptide Y
concentrations in selected hypothalamic sites and in vitro release from the medial basal
hypothalamus of castrated male rats. Endocrinology, 124:410-414, 1989.
99.
Sahu, A., Dube, M.G., Kalra, S.P. and Kalra, P.S.: Bilateral neural transections at the level of
mesencephalon increase food intake and reduce latency to onset of feeding in response to
neuropeptide Y. Peptides 9:1269-1273, 1989.
100.
Sahu, A., Jacobson, W., Crowley, W.R. and Kalra, S.P.: Dynamic changes in neuropeptide Y
concentrations in the median eminence in association with preovulatory luteinizing hormone (LH)
release in the rat. J. Neuroendocr., 1:83-87, 1989.
101.
Masotto, C., Sahu, A., Dube, M.G. and Kalra, S.P.: A decrease in opioid tone amplifies the LH
surge in estrogen-treated ovariectomized rats: Comparisons with progesterone effects.
Endocrinology 126:18-25, 1990.
102.
Sahu, A., Sninsky, C.A., Kalra, P.S. and Kalra, S.P.: Neuropeptide Y concentration in
microdissected hypothalamic regions and in vitro release from the medial-basal hypothalamuspreoptic area of streptozotocin-diabetic rats with and without insulin substitution therapy.
Endocrinology 126:192-198, 1990.
103.
Sahu, A., Crowley, W.R. and Kalra, S.P.: An opioid-NPY transmission line to LHRH neurons: A
role in the induction of LH surge. Endocrinology 126:876-883, 1990.
104.
Kalra, P.S., Sahu, A. and Kalra, S.P.: Interleukin-1 inhibits the ovarian steroid-induced luteinizing
hormone surge and release of hypothalamic luteinizing hormone-releasing hormone in rats.
Endocrinology, 126:2145-2152, 1990.
105.
Phelps, C.P., Kalra, P.S. and Kalra, S.P.: The effect of prior disconnection of the anterior
mediobasal hypothalamus on LHRH release in vitro. Brain Res. 515:208-214, 1990.
106.
Sahu, A., Kalra, S.P., Crowley, W.R. and Kalra, P.S.: Aging in male rats modifies castration and Tinduced NPY response in various microdissected brain nuclei. Brain Res. 515:287-291, 1990.
107.
Crowley, W.R., Shah, G.U., Carroll, B.L., Kennedy, D., Dockter, M.E. and Kalra, S.P.:
Neuropeptide Y enhances LHRH-induced LH release and elevations in cytosolic Ca2+ in anterior
pituitary cells: Evidence for involvement of extracellular Ca 2+ influx through voltage-sensitive
channels. Endocrinology, 127:1487-1494, 1990.
44
108.
Sar, M., Sahu, A., Crowley, W.R. and Kalra, S.P.: Localization of neuropeptide Y (NPY)
immunoreactivity in estradiol concentrating cells in the hypothalamus. Endocrinology 127:27522756, 1990.
109.
Sahu, A., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Functional Heterogeneity in neuropeptide Yproducing cells in the rat brain as revealed by testosterone action. Endocrinology 127:2307-2312,
1990.
110.
Kalra, P.S., Fuentes, M., Sahu, A and Kalra, S.P.: Endogenous opioid peptides mediate the
interleukin-1-induced inhibition of the release of luteinizing hormone releasing hormone and
luteinizing hormone. Endocrinology 127:2381-2386, 1990.
111.
Parker, S.L., Kalra, S.P. and Crowley, W.R.: Neuropeptide Y modulates the binding of a
gonadotropin-releasing hormone (GnRH) analogue to anterior pituitary GnRH receptor sites.
Endocrinology, 128:2309-2316, 1991.
112.
Kalra, S.P., Dube, M.G. and Kalra, P.S.: Neuropeptide K (NPK) suppresses copulatory behavior in
male rats. Physiol. Behav., 49:1297-1300, 1991.
113.
Kalra, S.P., Dube, M.G., Fournier, A. and Kalra, P.S.: Structure-function analysis of stimulation of
food intake by neuropeptide Y: Effects of receptor agonists. Physiol. Behav., 50:5-9, 1991.
114.
Kalra, S.P., Dube, M.G., Sahu, A., Phelps, C. and Kalra, P.S.: Neuropeptide Y secretion increases
in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad.
Sci., 88:10931-10935, 1991.
115.
Clark, J.T., Sahu, A., Mrotek, J.J. and Kalra, S.P.: Sexual function and neuropeptide Y levels in
selected brain regions of male spontaneously hypertensive rats. Am. J. Physiol. 261:R1234R1241, 1991.
116.
Phelps, C.P., Kalra, S.P. and Kalra, P.S.: In vivo pulsatile LHRH release in the anterior pituitary of
the male rat: Effects of castration. Brain Res., 569:159-163, 1992.
117.
Sahu, A., Crowley, W.R., Kalra, P.S. and Kalra, S.P.: A selective sexually dimorphic response in
the median eminence Neuropeptide Y. Brain Res., 573:235-242, 1992.
118.
Sahu, A. and Kalra, S.P.: Effects of tachykinins on LH release in female rats: Potent inhibitory
action of neuropeptide K (NPK). Endocrinology, 130:1571-1577, 1992.
119.
Kalra, S.P., Fuentes, M., Fournier, A., Parker, S.L. and Crowley, W.R.: Involvement of the Y-1
receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats.
Endocrinology 130:3323-3330, 1992.
120.
Sahu, A., Phelps, C.P., White, J.D., Crowley, W.R., Kalra, S.P. and Kalra, P.S.: Steroidal
regulation of hypothalamic neuropeptide Y release and gene expression. Endocrinology,
130:3331-3336, 1992.
121.
Fuentes, M., Sahu, A. and Kalra, S.P.: Evidence that long-term estrogen treatment disrupts opioid
involvement in the induction of pituitary LH surge. Brain Res., 583:183-188, 1992.
122.
Sahu, A., White, J.D., Kalra, P.S. and Kalra, S.P.: Hypothalamic neuropeptide Y gene expression
in rats on scheduled feeding regimen. Molec. Brain Res. 15:15-18, 1992.
45
123.
Dube, M.G., Sahu, A., Kalra, P.S. and Kalra, S.P.: Neuropeptide Y release is elevated from the
microdissected paraventricular nucleus of food-deprived rats. An in vitro study. Endocrinology,
131:684-688, 1992.
124.
Horvath, T.L., Naftolin, F., Kalra, S.P. and Leranth, C.: Neuropeptide Y innervation of β-endorphincontaining cells in the rat mediobasal hypothalamus: A light and electron microscopic double
immunostaining analysis. Endocrinology, 131:2461-2467, 1992.
125.
Kalra, P.S., Sahu, A., Bonavera, J.J. and Kalra, S.P.: Diverse effects of tachykinins on LH release
in male rats: Mechanism of action. Endocrinology, 131:1195-1201, 1992.
126.
Dube, M.G., Sahu, A., Phelps, C.P., Kalra, P.S. and Kalra, S.P. Effect of d-fenfluramine on
neuropeptide Y concentration and release in the paraventricular nucleus of food-deprived rats.
Brain Res. Bull., 29:865-869, 1992.
127.
Sahu, A., Sninsky, C.A., Dube, M.G., Kalra, P.S. and Kalra, S.P.: Neuropeptide Y (NPY) release
from the paraventricular nucleus increases in association with hyperphagia in streptozotocininduced diabetic rats. Endocrinology, 131:2979-2985, 1992.
128.
Phillips, M.I., Wang, H., Kimura, B., Rejtman, M., Koduri, P. and Kalra, S.P.: Dynamic changes in
hypothalamic angiotensin II levels and release in association with progesterone-induced LH surge.
Endocrinology, 132:1637-1642, 1993.
129.
Kalra, P.S. and Kalra, S.P.: Neuropeptide K stimulates corticosterone release in the rat. Brain
Res. 610:330-333, 1993.
130.
Bonavera, J.J., Kalra, S.P. and Kalra, P.S.: Mode of action of interleukin 1 suppression of pituitary
LH release in castrated male rats. Brain Research, 612:1-8, 1993.
131.
Bonavera, J.J., Kalra, S.P. and Kalra P.S.: Evidence that luteinizing hormone suppression in
response to inhibitory neuropeptides - β-endorphin, interleukin-1β and neuropeptide K - may
involve excitatory amino acids. Endocrinology 133:178-182, 1993.
132.
Xu, B., Sahu, A., Crowley, W.R., Leranth, C., Horvath, T. and Kalra, S.P.: Role of neuropeptide Y
in episodic LH release in ovariectomized rats: An excitatory component and opioid involvement.
Endocrinology, 133:747-754, 1993.
133.
Sahu, A., Crowley, W.R., Kalra, S.P. and Kalra, P.S.: Role of multiple voltage-sensitive calcium
channels in depolarization-induced release of neuropeptide Y and luteinizing hormone-releasing
hormone from rat median eminence-arcuate nucleus. Molec. Cell. Neurosci., 4:492-498, 1993.
134.
Bonavera, J.J., Sahu, A., Kalra, P.S. and Kalra, S.P.: Evidence that nitric oxide (NO) may mediate
the ovarian steroid-induced luteinizing hormone surge: Involvement of excitatory amino acids.
Endocrinology, 133:2481-2487, 1993.
135.
Sahu, A., Xu, B., Kalra, S.P.: Role of galanin (GAL) in stimulation of pituitary LH secretion as
revealed by a specific receptor antagonists - Galantide. Endocrinology, 134:529-536, 1994.
136.
Sahu, A., Crowley, W.R. and Kalra, S.P.: Hypothalamic neuropeptide Y gene expression
increases before the onset of ovarian steroid-induced luteinizing hormone surge. Endocrinology,
134:1018-1022, 1994.
137.
Bonavera, J.J., Dube, M.G., Kalra, P.S. and Kalra, S.P.: Anorectic effects of estrogen may be
mediated by decreased neuropeptide Y release in the hypothalamic paraventricular nucleus.
46
Endocrinology, 134:2367-2370, 1994.
138.
Dube, M.G., Xu, B., Crowley, W.R., Kalra, P.S. and Kalra, S.P.: Evidence that neuropeptide Y is a
physiological signal for normal food intake. Brain Res., 646:341-344, 1994.
139.
Dube, M.G., Horvath, T.L., Leranth, C., Kalra, P.S. and Kalra, S.P.: Naloxone reduces feeding
evoked by intracerebroventricular galanin injection. Physiol. Behav., 56:811-813, 1994.
140.
Kalra, P.S., Dube, M.G. and Kalra, S.P.: Facilitatory effects of testosterone on hypothalamic
tachykinin levels and release. Brain Res. 653:285-288, 1994.
141.
Kalra, P.S., Dube, M.G. and Kalra, S.P.: The effects of Interleukin-1β on the hypothalamic
tachykinin - Neurokinin A. Brain Res. 662:178-184, 1994.
142.
Bonavera, J.J., Sahu, A., Kalra, S.P. and Kalra, P.S.: The hypothalamic peptides, β-endorphin,
neuropeptide K and interleukin-1β, and opiate morphine, enhance the excitatory amino acidinduced LH release under the influence of gonadal steroids. J. Neuroendocrinol. 6:557-564, 1994.
143.
Crowley, W.R. and Kalra, S.P.: Neonatal exposure to estradiol prevents the expression of ovarian
hormone-induced luteinizing hormone and prolactin surges in adulthood, but not antecedent
changes in neuropeptide Y or adrenergic transmitter activity. Implications for sexual differentiation
of gonadotropin secretion. Brain Res., 663:257-265, 1994.
144.
Bonavera, J.J., Kalra, P.S. and Kalra, S.P.: Evidence in support of nitric oxide (NO) involvement in
the cyclic release of prolactin and LH surges. Brain Res. 660:175-179, 1994.
145.
Li, B-H., Xu, B., Rowland, N.E. and Kalra, S.P.: c-fos expression in the rat brain following central
administration of Neuropeptide Y and the effects of food consumption. Brain Res., 665:277-284,
1994.
146.
Horvath, T.L., Leranth, C ., Kalra, S.P. and Naftolin, L.: Galanin neurons exhibit estrogen receptor
immunoreactivity in the female rat brain. Brain Res., 675:321-324, 1995.
147.
Sahu, A., Crowley, W.R. and Kalra, S.P.: Evidence that hypothalamic neuropeptide Y gene
expression increases before the onset of the preovulatory LH surge. J. Neuroendocrinol. 7:291296, 1995.
148.
Kalra, S.P., Pearson, E., Sahu, A. and Kalra, P.S.: Agmatine, a novel hypothalamic amine,
stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormonereleasing hormone release in vitro. Neurosci. Lett. 194:165-168, 1995.
149.
Phelps, C.P., Sahu, A., Oliver, J., Ma, X-G., Kalra, P.S., Kalra, S.P., Menzies, R.A., Cheril Denker,
M., Horvath. E. and Poole, L.L. In vivo release of Interleukin-1β (IL-1β) into hypothalamic
extracellular fluid in rats: Effects of repeated sampling. Brain Res. 688:193-197, 1995.
150.
Horvath, T.L., Kalra, S.P., Naftolin, F. and Leranth C.: Morphological evidence for a galanin-opiate
interaction in the rat mediobasal hypothalamus. J. Neuroendo. 7:579-588, 1995.
151.
Kalra, P.S., Bonavera, J.J. and Kalra, S.P.: Central administration of antisense
oligodeoxynucleotides to neuropeptide Y (NPY) mRNA reveals the critical role of newly
synthesized NPY in regulation of LHRH release. Reg. Peptides, 59:215-220, 1995.
152.
Sahu, A., Dube, M.G., Phelps, C.P., Sninsky, C.A., Kalra, P.S. and Kalra, S.P.: Insulin and insulinlike growth factor II suppresses neuropeptide Y release from the nerve terminals in the
paraventricular nucleus: A putative hypothalamic site for energy homeostasis. Endocrinology,
47
136:5718-5724, 1995.
153.
Xu, B., Li, B-H., Rowland, N.E. and Kalra, S.P.: Neuropeptide Y injection into the fourth
cerebroventricle stimulates c-fos expression in the paraventricular nucleus and other nuclei in the
forebrain: Effects of food consumption. Brain Res. 698:227-231, 1995.
154.
Dube, M.G., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Evidence of a physiological role for
neuropeptide Y in ventromedial hypothalamic lesion-induced hyperphagia. Brain Res., 690:275278, 1995.
155.
Kalra, P.S., Norlin, M. and Kalra, S.P.: Neuropeptide Y stimulates β-endorphin release in the basal
hypothalamus: Role of gonadal steroids. Brain Res., 705:353-356, 1995
1996:
156.
Xu, G., Sahu, A., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Disinhibition of opioid influence
augments hypothalamic neuropeptide Y gene expression and pituitary LH release: Effects of NPY
mRNA antisense oligodeoxynucleotides. Endocrinology, 137:78-84, 1996.
157.
Pu, S., Xu, B., Kalra, S.P. and Kalra, P.S.: Evidence that gonadal steroids modulate nitric oxide
efflux in the medial preoptic area: Effects of N-methyl-D-aspartate and correlation with LH
secretion. Endocrinology, 137:1949-1955, 1996.
158.
Bonavera, J.J., Kalra, P.S. and Kalra, S.P.: L-Arginine/nitric oxide amplifies the magnitude and
duration of the LH surge induced by estrogen: Involvement of neuropeptide Y. Endocrinology
137:1956-1962, 1996.
159.
Parker, S.L., Carroll, B.L., Kalra, S.P., St. Pierre, S., Fournier, A. and Crowley, W.R.:
Neuropeptide Y Y2 receptors in the hypothalamic neuroendocrine areas are up-regulated by
estradiol and decreased by progesterone cotreatment in the ovariectomized rat. Endocrinology,
137:2896-2900,1996.
160.
Horvath, T.L., Naftolin, F., Leranth, C., Sahu, A. and Kalra, S.P.: Morphological and
pharmacological evidence for neuropeptide Y-Galanin interaction in the rat hypothalamus.
Endocrinology, 137:3069-3077, 1996.
161.
Xu, B., Pu, S., Kalra, P.S., Hyde, J.F., Crowley, W.R. and Kalra, S.P.: An interactive physiological
role of neuropeptide Y and galanin in pulsatile pituitary luteinizing hormone secretion.
Endocrinology 137:5297-5302,1996.
1997
162.
Pu, S., Horvath, T.L., Diano, S., Naftolin, F., Kalra, P.S. and Kalra, S.P.: Evidence showing that βendorphin regulates nitric oxide efflux: Anatomical and functional support for an interaction
between opiates and nitric oxide. Endocrinology, 138:1537-1543, 1997.
163.
Horvath, T.L., Bechmann, I., Naftolin, F., Kalra, S.P., Leranth, C.: Heterogeneity in the
neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic
subpopulations. Brain Res. 756:283-286, 1997.
164.
Sahu, A., Sninsky, C.A. and Kalra, S.P.: Evidence that hypothalamic neuropeptide Y gene
expression and NPY levels in the paraventricular nucleus increase before the onset of
hyperphagia in experimental diabetes. Brain Res. 755:339-342, 1997.
165.
Kalra, P.S., Dube, M.G., Xu, B. and Kalra, S.P.: Increased receptor sensitivity to neuropeptide Y in
48
the hypothalamus may underlie transient hyperphagia and body weight gain. Reg. Peptides
72:121-130, 1997.
1998
166.
Kalra, P.S., Dube, M.G., Xu, B., Farmerie, W.G. and Kalra, S.P.: Neuropeptide Y (NPY) Y1
receptor mRNA is upregulated in association with transient hyperphagia and body weight gain:
Evidence for a hypothalamic site for concurrent development of leptin resistance. J.
Neuroendocrinol. 10:43-49, 1998.
167.
Xu, B., Dube, M.G., Kalra, P.S., Kaibara, A., Moldawer, L., Martin, D. and Kalra, S.P.: Anorectic
effects of the cytokine, ciliary neurotropic factor (CNTF), are mediated by hypothalamic
neuropeptide Y (NPY): Comparison with leptin. Endocrinology 139:466-473, 1998.
168.
Kalra, S.P., Xu, B., Dube, M.G., Moldawer, L.L., Martin, D. and Kalra, P.S.: Leptin and ciliary
neurotropic factor (CNTF) inhibit fasting-induced suppression of LH release: Role of neuropeptide
Y. Neurosci. Lett. 240:45-49, 1998.
169.
Sahu, A. and Kalra, S.P.: Absence of increased NPY neuronal activity prior to and during the LH
surge may underlie the delayed and attenuated preovulatory LH surge in middle-aged rats.
Endocrinology 139:696-702, 1998.
170.
Yokosuka, M., Xu, B., Pu, S., Kalra, P.S. and Kalra, S.P.: Neural substrates for leptin and
neuropeptide Y (NPY) interaction: Selective hypothalamic sites associated with inhibition of NPYinduced food intake by leptin. Physiol. & Behav. 64:331-338, 1998.
171.
Pu, S., Kalra, P.S. and Kalra, S.P.: Ovarian steroid-independent diurnal rhythm in cyclic
GMP/Nitric oxide efflux in the medial preoptic area: Possible role in preovulatory and ovarian
steroid-induced LH surge. J. Neuroendocrinol. 10:617-626, 1998.
172.
Kalra, P.S., Dube, M.G., Xu, B., Farmerie, W.G. and Kalra, S.P.: Evidence that dark-phase
hyperphagia induced by neurotoxin 6-OHDA may be due to decreased Leptin and increased NPY
signaling. Physiol. & Behav. 63:829-835, 1998.
173.
Xu, B., Kalra, P.S., Moldawer, L.L. and Kalra, S.P.: Increase appetite augments hypothalamic Y1
receptor gene expression: effects of anorexigenic ciliary neurotropic factor. Reg. Peptides 7576:391-396, 1998.
174.
Kaibara, A., Moshyedi, A., Auffenberg, T., Abouhamze, A.S., Copeland, E.M., Kalra, S.P. and
Moldawer, L.L.: Leptin produces anorexia and weight loss without inducing an hepatic acute phase
response or wasting. Am J Physiol 274:R1518-1525, 1998.
175.
Kaibara, A., Espat, N.J., Auffenberg, T., Abouhamze, A.S., Martin, D., Kalra, S.P. and Moldawer,
L.L.: Interleukin-6, but not ciliary neurotrophic factor or leukemia inhibitory factor, is responsible for
the acute phase response to turpentine-induced myositis. Cytokines 10:452-456, 1998.
176.
Marín-Bivens, C.L., Kalra, S.P. and Olster, D.H., Intraventricular injection of neuropeptide Y antisera
curbs weight gain and feeding, and increases the display of sexual behaviors in obese Zucker female
rats. Regulatory Peptides 75-76:327-334, 1998.
177.
Clark, J.T., Keaton, A.K., Sahu, A., Kalra, S.P., Mahajan, S.C. and Gudger, J.N.: NPY levels in
alcoholic and food restricted male rats: Implications for site selective function. Regulatory Peptides
75-76:335-346, 1998.
178.
Diano, S., Kalra, S.P. and Horvath, T.L.: Leptin receptors with the golgi apparatus of hypothalamic
49
cells. J. Neuroendocrinol. 10:647-650, 1998.
179.
Koyama, K., Shimabukuro, M., Chen Guoxun, Wang, N-Y., Lee, Y., Kalra, P.S., Dube, M.G., Kalra,
S.P., Newgard, C., and Unger, R.: Resistance to adenovirally-induced hyperleptinemia in rats:
Comparisons of ventromedial hypothalamic lesions with mutated leptin receptors. J. Clin. Invest.
102:728-733, 1998.
180.
Jain, M.R., Dube, M.G., Kalra, S.P., and Kalra, P.S. Neuropeptide Y release in the paraventricular
nucleus is decreased during transient hyperphagia induced by microinjection of colchicine into the
ventromedial nucleus of rats. Neurosci Lett 256:21-24, 1998.
181.
Pu, S., Kalra, P.S., and Kalra, S.P. Diurnal rhythm in cyclic GMP/nitric oxide efflux in the medial
preoptic area of male rats. Brain Res. 804:310-312, 1998.
182.
Diano, S., Kalra, S.P., Sakamoto, H. and Horvath T.L.: Leptin receptors in estrogen receptors
containing neurons of the female rat hypothalamus. Brain Res 812:256-259, 1998.
183.
Pu, S., Jain, M.R., Kalra, P.S. and Kalra, S.P.: Orexins, a novel family of hypothalamic
neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent
manner. Reg. Peptides 78:133-136, 1998.
1999
184.
Pu, S., Jain, M.R., Horvath, T.L., Diano, S., Kalra, P.S. and Kalra, S.P.: Interactions between
neuropeptide Y and γ-aminobutyric acid in stimulation of feeding: A morphological and
pharmacological analysis. Endocrinology. 140:933-940, 1999.
185.
Dube, M.G., Xu, B., Kalra, P.S., Sninsky, C.A., and Kalra, S.P.: Disruption of neuropeptide Y and
leptin signaling in obese ventromedial hypothalamic lesioned-rats. Brain Res. 816:38-46, 1999.
186.
Pu, S., Dube, M.G., Edwards, T., Kalra, S.P., and Kalra, P.S.: Disruption of neural signaling within
the hypothalamic ventromedial nucleus upregulates galanin gene expression in association with
hyperphagia: An in situ hybridization analysis. Mol. Brain Res. 64:85-91, 1999.
187.
Xu, B., Kalra, P.S., Farmerie, W.G., Kalra, S.P.: Daily changes in hypothalamic gene expression of
neuropeptide Y, galanin, proopiomelanocortin and adipocyte leptin gene expression and secretion:
Effects of food deprivation. Endocrinology 140:2868-2875, 1999.
188.
Liu, H., Sanuda-Pena, C., Harvey-White, J.D., Kalra, S.P., and Cohen, S.A.: Determination of
submicromolar concentrations of neurotransmitter amino acid using fluorescence detection
via a
modification of the AOC method for amino acid analysis. J Chromatography 828:383- 395, 1999.
189.
Wang ZW, Zhou YT, Kakuma T, Lee Y, Higa M, Kalra SP, Dube MG, Kalra PS, Unger RH.
Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia. Proc
Natl Acad Sci U S A. 96:10373-10378, 1999.
190.
Yokosuka, M., Kalra, P.S., and Kalra, S.P.: Inhibition of neuropeptide Y (NPY)-induced feeding and cFOS response in magnocellular paraventricular nucleus by a NPY receptor antagonist:
A site of
NPY action. Endocrinology. 140:4494-4500, 1999.
191.
Wang ZW, Zhou YT, Lee Y, Higa M, Kalra SP, Unger RH. Hyperleptinemia depletes fat from
denervated fat tissue. Biochem Biophys Res Commun. 260:653-657, 1999.
192.
Dube, M.G., Kalra, S.P., and Kalra, P.S.: Food-intake elicited by central administration of
50
orexins/hypocretins: Identification of hypothalamic sites of action. Brain Res 140:51711999.
193.
5177,
Jain, M.R., Pu, S., Kalra, P.S., and Kalra, S.P.: Evidence that stimulation of two modalities of pituitary
luteinizing hormone release in ovarian steroid-primed ovarectomized rats may involve neuropeptide Y
Y1 and Y4 receptors. Endocrinology. 842:473-477, 1999.
2000
194.
Jain, M.R., Horvath, T.L., Kalra, P.S., and Kalra, S.P.: Evidence that NPY Y1 receptors are involved
in stimulation of feeding by orexins (hypocretins) in sated rats. Regul Peptides. 87: 19-24, 2000
195.
Dube, M.G., Kalra, S.P., and Kalra, P.S.: Hypothalamic galanin is upregulated during hyperphagia
and increased body weight induced by disruption of signaling in the ventromedial nucleus. Peptides
21: 519-526, 2000.
196.
Pu, S., Dhillon, H., Moldawer, L.L., Kalra, P.S., and Kalra, S.P.: Neuropeptide Y counteracts the
anorectic and weight reducing effects of ciliary neurotropic factor (CNTF). J Neuroendo. 12: 827832, 2000.
197.
Dube, M.G., Pu, Shuye, Kalra, P.S., and Kalra, S.P., Melanocortin signaling is decreased during
neurotoxin-induced transient hyperphagia and increased body weight gain. Peptides
21: 793-801,
2000.
198.
Dhillon, H., Ge, Y.L., Minter, R., Prima, V., Moldawer, L., Muzyczka, N., Zolotukhin, S., Kalra, P.S.,
and Kalra S.P.: Long-term differential modulation of genes encoding orexigenic and anorexigenic
peptides by leptin delivered by rAAV vector in ob/ob mice: Relationship with body weight change.
Regulatory Peptides, 92:97-105 2000.
199.
Pu, S., Dube, M.G., Kalra, P.S., and Kalra S.P. Regulation of leptin secretion: Effects of aging on
daily patterns of serum leptin and food consumption. Regulatory Peptides 92: 107-111, 2000.
200.
Dube, M.G., Horvath, T.L., Kalra, P.S. and Kalra S.P. Evidence of NPY Y5 receptor involvement in
food intake by orexin-A in sated rats. Peptides, 21: 1557-1560, 2000.
201.
Wang, Z., Zhou, Y-T, Kakuma, T., Lee, Y., Kalra, S.P., Kalra, P.S., Pan, W., and Unger, R.H., Leptin
resistance of adipocytes in obesity: role of suppressors of cytokine signaling; Biochemistry Biophy.
Res. Comm. 277: 20-26, 2000
2001
202.
Horvath, T.L., Pu, S., Dube, M.G., Diano, S. and Kalra, S.P. A GABA-Neuropeptide Y (NPY)
interplay in LH release. Peptide, 22: 473-481, 2001.
203.
Yokosuka, M., Dube, M., Kalra, P.S. and Kalra, S.P. The mPVN mediates blockade of the NPYinduced feeding by a Y5 receptor antagonist; a c-Fos analysis. Peptides 22:507-514, 2001
204.
Dhillon, H., Kalra, SP., Prima, V., Zolotukhin, S., Scarpace, P.J., Moldawer, L.L., Muzyczka, N., and
Kalra, PS. Central leptin gene therapy suppresses body weight gain, and adiposity and serum insulin
without affecting food consumption in normal rats: a long-term study. Regulatory Peptide 99: 69-77,
2001.
205.
Dhillon, H., Kalra, S.P., and Kalra, P.S., Dose-dependent effects of central leptin gene therapy on
genes that regulate body weight and appetite in the hypothalamus. Molecular Therapy, 4:139-145,
2001.
51
206.
German, I., Roper, M.G. Kalra, S.P. Rhinehart, E. and Kennedy, R.T., Capillary liquid
chromatography of multiple peptides with on-line capillary Electrophoresis Immunoassay detection.
Electrophoresis, 22:3659-3667, 2001.
2002
''
207.
Bagnasco, M., Kalra, P.S., and Kalra, S.P., Ghrelin and leptin pulse discharge in fed and fasted rats.
Endocrinology, 143:726-729, 2002.
208.
Bagnasco, M., Kalra, P.S. and Kalra, S.P. Plasma leptin levels are pulsatile in adult rats; effects of
gonadectomy. Neuroendocrinology, 75:257-263, 2002.
209.
Dube, M.G., Beretta, E., Dhillon, H., Ueno, N. Kalra, P.S., and Kalra, S.P. Central Leptin Gene
Therapy Blocks High Fat Diet-induced Weight Gain, Hyperleptinemia and Hyperinsulinemia: increase
in Serum Ghrelin levels. Diabetes, 51:1729-1736, 2002.
210.
Beretta, E., Dhillon, H., Kalra, P.S., and Kalra, S.P. Central LIF gene therapy suppresses food
intake, body weight, serum leptin and insulin for extended periods. Peptides, 23:975-984, 2002.
211.
Beretta, E., Dube, M.G., Kalra, P.S., and Kalra, S.P. Long-term suppression of weight gain,
adiposity and serum insulin by central gene therapy in prepubertal rats; effects on serum ghrelin and
appetite regulating genes. Pediatric Research, 52:189-198, 2002.
212.
213.
Bagnasco, M. Dube, M.G. Kalra, P.S. and Kalra, S.P. Evidence for the existence of distinct central
appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic sitespecific leptin gene therapy. Endocrinology, 143:4409-4421, 2002.
Ge., Y-L., Ohta, T., Driscoll, D., Nicholls, R., and Kalra, S.P. Anorexigenic melanocortin signaling
in the hypothalamus is augmented in association with failure-to-thrive in a transgenic mouse model
for Prader-Willi syndrome. Brain Res., 957:42-45, 2002.
2003
214.
Ster, A.M., Kowalski, T.J., Dube, M.G., Kalra, S.P. and Smith, G. P. Decreased hypothalamic
concentration of neuropeptide Y correlates with onset of hyperphagia in fa/fa rats on postnatal day
12. Physiology and Behavior, 78:517-520, 2003.
215.
Reibel, S., Le, B.T., Benmaamar, R., Thuyle, B., Larmet, Y., Kalra, S., Marescaux, C., Depaulis, A.
Neuropeptide Y delays hippocampal kindling in the rat. Hippocampus, 13:557-560, 2003.
216.
Bagnasco, M., Dube, M.G., Katz, A., Kalra, P.S. and Kalra, S.P. Leptin expression in
Hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin. Obesity
Res., 11:1463-1470, 2003.
2004
217.
Keen Rhinehart, E., Kalra, S.P., and Kalra P.S. Leptin receptor gene transfer into the arcuate
nucleus of female fatty Zucker rats using recombinant adeno-associated viral vectors stimulates
the hypothalamo-pitutary-gonadal axis. Biol Reprod., 71:266-272, 2004.
218.
Keen-Rhinehart, E., Kalra S.P., and Kalra P.S. Neuropeptidergic characterization of the leptin
receptor mutated obese Koletsky rat. Regulatory Peptides 119:3-10, 2004.
219.
Ueno, N., Dube, M.G., Katz, A, Kalra, P.S., and Kalra, S.P. Leptin modulates orexigenic effects of
52
ghrelin, and attenuates adiponectin and insulin levels, and selectively the dark-phase feeding as
revealed by central leptin gene therapy. Endocrinology, 145:4176-4184, 2004.
220.
221.
Crowley, W.R., Ramoz, G. Torto, R. and Kalra, S.P. Role of leptin in orexigenic neuropeptide
expression during lactation in rats. J. Neuroendo. 16:637-644, 2004.
2005
Kalra, S.P., Ueno, N., and Kalra P.S. Stimulation of appetite by ghrelin is regulated by leptin
restrain: peripheral and central sites of action. Journal of Nutrition, 1331-1335, 2005.
222.
Crowley, W.R., Ramoz, G., Keefe, K.A., Torto, R., Kalra, S.P. and Hanson, G. Differential effects
of methamphetamine on expression of neuropeptide Y mRNA in hypothalamus and serum leptin
and ghrelin concentrations in ad libitum and scheduled fed rats. Neuroscience 132:167-173,
2005.
223.
Lecklin, A., Dube, M.G., Torto, R., Kalra, P.S. and Kalra S.P. Perigestational suppression of
weight gain with central leptin gene therapy results in lower weight F1 generation. Peptides
26:1176-1187, 2005.
224.
Otukonyong, E.E., Dube, M.G., Torto, R.N., Kalra P.S., and Kalra, S.P. High Fat Diet-Induced
Ultradian Leptin and Insulin hypersecretion and ghrelin hyposecretion is absent in obesity-resistant
rats. Obesity Research, 13:991-999, 2005.
225.
Boghossian, S., Lecklin, A., Torto, R. Kalra, P.S. and Kalra, S.P. Suppression of fat deposition for
the lifetime of rodents with gene therapy. Peptides 26:1512-1519, 2005.
226.
Otukonyong, EE, Dube MG, Torto, R. Kalra, PS and Kalra SP. Central leptin differentially
modulates ultradian secretory patterns of insulin, leptin, and ghrelin independent of effects on food
intake and body weight. Peptides 26:2559-2566, 2005.
227.
Keen-Rhinehart, E., Kalra, S.P. and Kalra, P.S. AAV-mediated leptin receptor installation
improves energy balance and the reproductive status of obese female Koletsky rats. Peptides
26:2567-2578, 2005.
228.
Kennedy, L., Bittel, D.C., Kibiryeva, N., Kalra, S.P., Torto, R., Butler, M.G. Circulating adiponectin
levels, body composition and obesity related variables in Prader-Willi syndrome: comparison with
obese subjects. Int. J. Obesity 30:382-387, 2005.
229.
2006
Boghossian, S, Lecklin, A., Dube, M.G., Kalra, P.S., and Kalra, S.P. Increased leptin expression
in the dorsal vagal complex suppresses weight and adiposity for long-period without affecting
energy intake and metabolic hormones. Obesity Research, 14:1003-1009, 2006.
230.
Ueno, N., Inui, A., Kalra, P.S., and Kalra, S.P. Leptin transgene expression in the hypothalamus
enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese
ob/ob mice. Peptides, 27:2332-2342, 2006.
231.
Dube, M.G., Kalra, S.P., and Kalra, P.S. The Hypothalamic Paraventricular Nucleus is Not
Essential for Orexigenic NPY or Anorexigenic Melanocortin Action. Peptides, 27:2239-2248, 2006.
232.
Torto, R., Boghossian, S., Dube, M.G., Kalra, P.S., and Kalra, S.P. Central leptin gene blocks
ovariectomy-induced adiposity. Obesity, 14:1312-1319, 2006.
233.
Boghossian, S., Dube, M.G., Torto, R., Kalra P.S., and Kalra S.P. Hypothalamic clamp on insulin
release by leptin-transgene expression. Peptides 27:3245-3254, 2006.
53
2007
234.
Boghossian, S., Ueno, N., Dube, M.G., Kalra P.S., and Kalra S.P. Leptin gene transfer in the
hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating
leptin. Neurobiology of Aging 28:1594-604, 2007.
235.
Iwaniec, U.T., Boghossian, S., Lapke, P.D., Turner, R.T., Kalra, S.P. Central leptin gene therapy
corrects skeletal abnormalities in leptin-deficient ob/ob mice. Peptides 28:1012-9, 2007.
236.
Kalra, S.P. Global life-long health benefits of repression of hypothalamic NPY system by central
leptin gene therapy. Current Topics in Medicinal Chemistry 7:1675-81, 2007.
2008-2009
237.
Dube, M.G., Torto, R., Kalra, S.P. Increased leptin expression selectively in the hypothalamus
suppresses the biomarkers of cardiovascular diseases, C-reactive protein (CRP) and interleukin-6
(IL-6), in leptin-deficient diabetic obese ob/ob mice. Peptides 29:593-8, 2008.
238.
Iwaniec, U., Dube, M.G., Boghossian, S., Song, H., Helferich, W., Turner, R.T., Kalra, S.P. Body
mass influences cortical bone mass independent of leptin signaling. Bone 44:404-12, 2009.
239.
Malhotra, A., Vashistha, H., Yadav, V.S., Dube, M.G., Kalra, S.P., Abdellatif, M., Meggs, L.G.
Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced
oxidative stress and apoptosis. American Journal of Physiology-Heart and Circulatory Physiology
296:380-8, 2009.
240.
Kojima, S., Asakawa, A., Amitani, H., Sakoguchi, T., Ueno, N., Inui, A., Kalra, S.P. Central leptin
gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and
promote survival in insulin-deficient diabetic mice. Peptides 30:962-6, 2009.
241.
Kalra, S.P., Dube, M.G., Iwaniec, U.T. Leptin increases osteoblast-specific osteocalcin release
through a hypothalamic relay. Peptides 30:967-73, 2009.
2010-2011
242.
Fetissov,S.,Laviano,A.,Kalra,S.,and Inui,A., Update on Ghrelin . Int. J. Peptides,1-4,2010
243.
Iwaniec, U.,Boghossian,S.,Trevisiol,B.,Wronski,T.,Turner,R.,Kalra,S.,Hypothalamic Leptin
Gene Therapy Prevents Weight Gain without long-term detrimental effects on bone in growing and
skeletally mature female rats. J of Bone and Mineral Research 26:1506-1511, 2011.
244.
Jackson, M.A., Iwaniec,U.T., Turner,R.T., Wronski,T.J.,Kalra,S.P., Effects of increased
hypothalamic leptin expression on ovariectomy-induced bone loss in rats. Peptides 32:1575-1580,
2011
Recognition of Published Articles (citation classic), #4, page 20
54
RESEARCH (cont.)
PUBLICATIONS (Cont.)
C.
ABSTRACTS OF PAPERS PRESENTED:
1.
Kalra, S.P., Velasco, M.E. and Sawyer, C.H.: Effect of hypothalamic deafferentation and estrogen
treatment on FSH release in immature female parabiotic rats. The Physiologist, 12:265, 1969.
2.
Kalra, S.P., Ajika, K., Krulich, L., Fawcett, C.P., Quijada, M. and McCann, S.M.: Effect of
hypothalamic and preoptic electrochemical stimulation on gonadotropin and prolactin release in
proestrus rats. The Physiologist, 13:239, 1970.
3.
Kalra, P.S., Krulich, L., Quijada, M., Kalra, S.P. and Fawcett, C.P.: Effects of gonadal steroids on
plasma gonadotropins and prolactin. 52nd Ann. Mtg. Endocrine Soc., pp. 126, 1970.
4.
Kalra, P.S., Krulich, L., Quijada, M., Kalra, S.P., Fawcett, C.P. and McCann, S.M.: Feedback of
gonadal steroids on gonadotropins and prolactin in the rat. Excerpta Medica Internatl. Congr. Series
No. 219:708-715, 1970.
5.
Kalra, S.P. and McCann, S.M.: Variations in the release of LH in response to electrochemical
stimulation of the medial preoptic area (MPOA) during the estrous cycle of the rat. Fed. Proc.,
31:212, 1972.
6.
McCann, S.M., Kalra, P.S., Kalra, S.P., Ajika, K., Libertun, C., Cooper, K.J., Fawcett, C.P. and
Krulich, L.: Control of adenohypophyseal secretion by hypothalamic releasing and inhibiting
neurohormones. Excerpta Medical Internatl. Congr. Series No. 273:107-111, 1972.
7.
McCann, S.M., Fawcett, C.P., Donoso, A.P., Kalra, P.S., Kalra, S.P., Quijada, M., Schneider, H.P.G.,
Watson, J.R., Wakabayashi, K. and Krulich, L.: Regulation of the secretion of gonadotropins and
prolactin by hypothalamic neurohormones. Excerpta Medica Internatl. Congr. Series No. 278, 1973.
8.
Kalra, S.P., Kalra, P.S. and Abrams, R.M.: Peripheral blood LH, estrogen (E2) and progestins (P)
during the rat estrous cycle. Fed. Proc., 32:377, 1973.
9.
Kalra, S.P. and Kalra, P.S.: Fluctuations in peripheral serum estradiol and LH levels during estrous
cycle: Effects of progesterone and centrally acting anti-ovulatory drugs in the bovine induced by PGF.
55th Ann. Mtg. Endocr. Soc., 92:113, 1973.
10.
Kalra, S.P.: Studies on the blockade of estradiol benzoate (EB) induced LH release by actinomycin
(Act-D). Fed. Proc., 33:321, 1974.
11.
Kalra, S.P.: Evidence for a two-step estrogen action in the facilitation of preovulatory LH release.
XXVI Internat. Congr. Physiol. Sci., New Delhi, pp. 750, Oct. 1974.
12.
Kalra, S.P.: Modification by 6-hydroxydopamine (6-OHDA) of ovarian steroid feedback action on LH
release mechanisms. 57th Ann. Mtg. Endocr. Soc., pp. 100, 1975.
13.
Kalra, S.P.: Temporal changes in serum LH-releasing factor (LRF), luteinizing hormone (LH), and
hypothalamic LRF following progesterone (P) treatment of estrogen-primed ovariectomized rats:
Effects of cycloheximide. Fed. Proc., 35:700, 1976.
14.
Kalra, P.S., Gotthelf, G. and Kalra, S.P.: Luteinizing hormone-releasing hormone (LH-RH) activity
during the rat estrous cycle. Gynec. Invest., 7:7, 1976.
55
15.
Kalra, P.S. and Kalra, S.P.: Temporal interrelationships among hormonal rhythms in male rats. Vth
Internat. Congr. Endocrinology, Hamburg, 1976.
16.
Kalra, S.P.: Alterations in brain LH-RH and gonadotropin release following anterior hypothalamic
deafferentation (AHD) and estradiol benzoate (EB) treatment. Fed. Proc., 35:700, 1976.
17.
Kalra, S.P. and Mitchell, E.O.: Leucine-3H incorporation into the proteins of hypothalamus and
pituitary and LH release following estrogen treatment. Gynec. Invest., 8:54, 1977.
18.
Kalra, S.P. and Kalra, P.S.: Temporal changes in the hypothalamic and serum luteinizing hormonereleasing hormone (LH-RH) levels and the circulating ovarian steroids during the rat estrous cycle.
Fed. Proc., 36:300, 1977.
19.
Kalra, P.S. and Kalra, S.P.: Effects of subcutaneous and intracranial implants of testosterone (T) on
the hypothalamic LHRH activity in castrated rats. Fed. Proc., 37:296, 1978.
20.
Kalra, S.P. and Kalra, P.S.: Dynamic changes in hypothalamic and serum LHRH levels associated
with ovarian steroid-induced LH surge: Effects of norepinephrine (NE) synthesis inhibitors. 25th Ann.
Mtg. Soc. Gynec. Invest., pp. 10, 1978.
21.
Cantor, B., Kalra, S.P., Kalra, P.S., Riggall, F.C. and Birk, S.: Peripheral levels of luteinizing hormone
releasing factors (LRF) during the menstrual cycle and after progesterone administration. 26th Ann.
Mtg. Soc. Gynec. Invest., pp. 154, 1979.
22.
Kalra, P.S. and Kalra, S.P.: Gonadal steroids and hypothalamic LHRH. 26th Ann. Mtg. Soc. Gynec.
Invest., pp. 73, 1979.
23.
Simpkins, J.W., Kalra, P.S. and Kalra, S.P.: Progesterone-induced temporal alterations in LHRH
concentrations in several brain nuclei: Effects of NE synthesis inhibitor, diethyl-dithiocarbamate
(DDC). Am. Physiol. Soc. Campus Specialty Mtg., 1979.
24.
Simpkins, J.W, Estes, K.S., Kalra, P.S. and Kalra, S.P.: Age-related alterations in catecholamine and
LHRH concentration in brain nuclei of the male rat. Congr. on Aging., 1979.
25.
Kalra, P.S., Simpkins, J.W. and Kalra, S.P.: Effects of androgens on hypothalamic catecholamine
turnover and gonadotropin secretion. Fed. Proc., 39:586, 1980.
26.
Simpkins, J.W., Kalra, P.S.D. and Kalra, S.P.: Effects of pentobarbital (Pnt) on hypothalamic LHRH
and catecholamines in ovariectomized steroid-pretreated rats. Fed. Proc., 39:585, 1980.
27.
Estes, K.S., Simpkins, J.W. and Kalra, S.P.: Stimulation of episodic LH release with the adrenergic
agonist - clonidine. 62nd Annual Meeting Endocrine Society, pp. 107, 1980.
28.
Simpkins, J.W. and Kalra, S.P.: Evidence for noradrenergic (NE) mediation of opioid effects on LH
secretion. 62nd Annual Meeting Endocrine Society, pp. 235, 1980.
29.
Kalra, S.P., Simpkins, J.W., Chen, C.L.: The opioid-catecholamine modulation of gonadotropin and
prolactin secretion. Workshop on Functional Correlates of Hormone Receptors in Reproduction,
Augusta, GA, Oct. 13-15, 1980.
30.
Kalra, P.S., Simpkins, J.W. and Kalra, S.P.: Hyperprolactinemia counteracts the testosterone
inhibition of preoptic dopamine turnover. Fed. Proc., 40:415, 1981.
56
31.
Kumar, M.S., Chen, C.L., Kalra, S.P., Kalra, P.S. and Sharp, D.C.: Diurnal changes in hypothalamic
and pituitary methionine-enkephalin content. Fed. Proc., 40:1150, 1981.
32.
Estes, K., Simpkins, J.W. and Kalra, S.P.: Effects of advancing age and ovariectomy on LHRH
concentrations in discrete preoptic area and hypothalamic regions of the rat. 63rd Ann. Mtg.
Endocrine Society, Cincinnati, OH, pp. 201, 1981.
33.
Kalra, S.P.: Naloxone responsive sites in steroid pretreated rats: Advancement of LH surge. 63rd
Annual Meeting Endocrine Society, Cincinnati, OH, pp. 289, 1981.
34.
Kalra, P.S., Simpkins, J.W., Luttge, W.G. and Kalra, S.P.: Effects of pituitary tumor-induced
hyperprolactinemia on copulatory behavior and the preoptic dopamine (DA) neurons. 64th Ann. Mtg.
Endocr. Soc., pp. 359, 1982.
35.
Leadem, C.A. and Kalra, S.P.: Stimulation with progesterone of LHRH secretion from perifused
female rat hypothalami. 64th Ann. Mtg. Endocr. Soc., pp. 208, 1982.
36.
Kalra, S.P. and Jordan, J.: Role of progesterone (P) in eliciting LHRH increments prior to the
preovulatory LH surge. 29th Ann. Mtg. Soc. Gyn. Invest., Dallas, TX, pp. 145, 1982.
37.
DeVane, G.W., Buhi, W.C., Kalra, S.P. and Kalra, P.S.: The effect of pergolide treatment on
naloxone-induced LH release in hyperprolactinemic women. 29th Ann. Mtg. Soc. Gynec. Invest., pp.
79, 1982.
38.
Kalra, P.S. and Kalra, S.P.: Discriminative effects of testosterone (T) on hypothalamic LHRH levels
and LH secretion in castrated male rats. 29th Ann. Mtg. Soc. Gynec. Invest., pp. 146, 1982.
39.
Kalra, S.P. and Gallo, R.V.: Mode of opiate action in suppressing LH release. 30th Annual Meeting
Society Gynecologic Investigation, Washington, DC, 1983.
40.
DeVane, G.W., Kalra, S.P., Kalra, P.S. and Riggall, F.C.: Effect of progesterone on naloxoneinduced luteinizing hormone (LH) release in postmenopausal women. 30th Annual Meeting Society
Gynecologic Investigation, Washington, DC, pp. 61, 1983.
41.
Kalra, S.P.: Epinephrine (E) neurons control preovulatory luteinizing hormone (LH) secretion in the
rat. 13th Annual Meeting Society for Neuroscience, Boston, MA, Nov. 6-11, 1983.
42.
Kalra, P.S., Simpkins, J.W. and Kalra, S.P.: Hyperprolactinemia, sex behavior and dopamine (DA)
activity: A correlative Study. III Pan Am. Congr. Androl., Cartagena, Columbia, pp. 42, 1983.
43.
Gabriel, S.M., Simpkins, J.W., Kalra, S.P. and Kalra, P.S.: Morphine induced hypersensitivity in LH
response to testosterone. 65th Annual Meeting Endocrine Society, San Antonio, TX, pp. 128, 1983.
44.
Leadem, C.A. and Kalra, S.P.: The effects of various opiate receptor agonists on luteinizing hormone
(LH) and prolactin (PRL) secretion in ovariectomized rats. 65th Annual Meeting Endocrine Society,
San Antonio, TX, June 7-10, 1983.
45.
DeVane, G.W. and Kalra, S.P.: Naloxone-induced gonadotropin and prolactin release in
postmenopausal women following estrogen and progesterone treatment. 31st Annual Meeting
Society Gynecol. Invest., San Francisco, CA, March 21-24, 1984.
46.
Kalra, S.P.: Intrahypothalamic events mediating progesterone (P)-induced blockade of LH release.
3lst Annual Meeting Society Gynecologic Investigation, San Francisco, CA, March 21-24, 1984.
57
47.
Kalra, P.S., Leadem, C.L. and Kalra, S.P.: Effects of testosterone (T) and naloxone on LHRH
secretion in vitro - relationship with hypothalamic LHRH concentration. Excerpta Medica Internatl.
Congr. Series, 652:882, 1984.
48.
Clark, J.T., Kalra, S.P. and Kalra, P.S.: Effect of inhibition of norepinephrine and/or epinephrine
synthesis on copulatory behavior and penile reflexes in rats. Conference on Reproductive Behavior,
University of Pittsburgh, pp. 38, 1984.
49.
Clark, J.T., Crowley, W.R. and Kalra, S.P.: Neuropeptide Y and human pancreatic polypeptide (hPP)
stimulate feeding in the rat. 7th International Congress of Endocrinology, Quebec, CAN, July 1-5,
1984.
50.
Kalra, S.P. and Crowley, W.R.: Norepinephrine-like effects of neuropeptide Y (NPY) and human
pancreatic polypeptide. 14th Annual Meeting Society Neuroscience, Anaheim, CA, Oct. 8-16, 1984.
51.
Kalra, S.P., Clark, J.T., Allen, L.G. and Kalra, P.S.: Effects of Neuropeptide Y (NPY) on feeding and
sexual behaviors and gonadotropin release in the male rat. Vth International Washington Spring
Symposium, Washington, DC, May 28-31, 1985.
52.
Allen, L.G. and Kalra, S.P.: Evidence that decrease in opioid influence may facilitate proestrus LH
surge. 67th Annual Meeting Endocrine Society, Baltimore, MD, June 19-21, 1094:274, 1985.
53.
Clark, J.T. and Kalra, S.P.: Neuropeptide Y (NPY)-induced feeding: Comparison with rat pancreatic
polypeptide (rPP), human NPY, and peptide YY (PYY) in male and female rats. 15th Annual Meeting
Society Neuroscience, Dallas, TX, Oct. 20-25, 1985.
54.
Allen, L.G., Crowley, W.R. and Kalra, S.P.: Role of catecholamines and opiates in stimulation of LH
release by neuropeptide Y (NPY). 15th Annual Meeting Society Neuroscience, Dallas, TX, Oct. 2025, 1985.
55.
Fournet, N., Allen, L.G., Kalra, P.S. and Kalra, S.P.: Effects of a sustained decrease in opioid tone
on LH secretion in intact and long-term castrated rats. 15th Annual Meeting Society Neuroscience,
Dallas, TX, Oct. 20-25, pp. 469, 1985.
56.
Kalra, S.P. and Kalra, P.S.: Interactions between brain peptides and sex steroids in the control of
pituitary function. XII Meeting International Study Group on Steroid Hormones, Rome, Italy, Dec. 2-4,
1985.
57.
Sahu, A., Crowley, W.R., O'Donohue, T.L., Kalra, P.S. and Kalra, S.P.: Gonadal modulation of
neuropeptide Y release from the mediobasal hypothalamus (MBH) in vitro. 1st International
Congress Neuroendocrinology, San Francisco, CA, July 9-11, 35:32, 1986.
58.
Clark, J.T., Kalra, S.P. and Kalra, P.S.: Neuropeptide Y (NPY)-induced suppression of male sexual
behavior: Neural loci. 1st International Congress of Neuroendocrinology, San Francisco, CA, July 911, 35:107, 1986.
59.
Allen, L.G., Caton, D. and Kalra, S.P.: Preovulatory LH surge in the rat: Pulse analysis and
advancement by opioid receptor blockade. 1st International Congress of Neuroendocrinology, San
Francisco, CA, July 9-11, pp. 109, 1986.
60.
Crowley, W.R., Hassid, A. and Kalra, S.P.: Evidence for dual sites of action for neuropeptide Y in
stimulation of luteinizing hormone release. 16th Annual Meeting Society Neuroscience, Washington,
DC, pp. 1414, 1986.
58
61.
Clark, J.T., Kalra, S.P. and Kalra, P.S.: Neural sites mediating neuropeptide Y (NPY)-induced
behavioral alterations. 5th Florida Neuroendocrine Symposium, 1986.
62.
Kalra, S.P., Crowley, W.R. and Kalra, P.S.: Different modes of NPY receptor activation may regulate
LH secretion and feeding behavior. 16th Annual Meeting Society Neuroscience, Washington, DC,
pp. 1494, 1986.
63.
Kalra, S.P., Kalra, P.S., Allen, L.G., Sahu, A. and Crowley, W.R.: The neuropeptide-steroid
connection in the control of LHRH secretion. Workshop on Regulation of Ovarian and Testicular
Function. Augusta, GA, Feb. 7-9, pp. 10, 1987.
64.
Sahu, A. and Kalra, S.P.: Evidence that novel neuropeptidergic systems may mediate sleepassociated LH hypersecretion. 34th Annual Meeting Society for Gynecologic Investigation, Atlanta,
GA, March 18-21, pp. 34, 1987.
65.
Kalra, S.P., Clark, J.T. and Kalra, P.S.: Regulation of male sexual behavior. IV Pan American
Congress Andrology and Serono Symposium on Human Reproduction, Sao Paulo, Brazil, May 3-6,
1987.
66.
Kalra, S.P., Allen, L.G., Sahu, A., Crowley, W.R. and Kalra, P.S.: Gonadal steroids and opioidneuropeptide Y-LHRH axis: Interaction and diversities. 8th International Symposium, Journal of
Steroid Biochemistry, Paris, France, May 24-27, 1987.
67.
Sahu, A., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Site-specific changes in neuropeptide Y (NPY)
levels in the hypothalamus: Effects of castration and adrenalectomy. 69th Annual Meeting Endocrine
Society, Indianapolis, June, 1987.
68.
Kalra, S.P., Kalra, P.S., Allen, L.G., Sahu, A. and Crowley, W.R.: NPY-catecholamine-steroid link in
the control of LH release. 6th International Catecholamine Symposium, Jerusalem, Israel, June 1419, 1987.
69.
Sahu, A., Tatemoto, K. and Kalra, S.P.: Inhibitory effects of neuropeptide K (NPK) on LH release in
rats. Soc. for the Study of Reproduction, Urbana, IL, July, pp. 152, 1987.
70.
Kalra, S.P., Allen, L.G. and Kalra, P.S.: Opioid participation in the gonadal steroid-adrenergic circuit
regulating LH secretion: Dynamics and diversities. Symposium on Brain Opioid Systems in
Reproduction, Babraham, Cambridge, England, Sept. 6-9, 1987.
71.
Allen, L.G., Crowley, W.R. and Kalra, S.P.: α2-adrenoreceptor blockade differentially affects
stimulation of LH and feeding in response to neuropeptide Y (NPY). 17th Annual Meeting Society for
Neuroscience, New Orleans, LA, Nov. 16-21, pp. 1527, 1987.
72.
Sahu, A., Kalra, P.S. and Kalra, S.P.: Fasting increases and refeeding reinstates neuropeptide Y
(NPY concentrations in the paraventricular nucleus (PVN). 17th Annual Meeting Society
Neuroscience, New Orleans, LA, Nov. 16-21, pp. 586, 1987.
73.
Kalra, S.P., Dube, M.G. and Kalra, P.S.: Continuous intraventricular infusion of neuropeptide Y (NPY)
evokes episodic food intake in satiated female rats: Effects of adrenalectomy and cholecystokinin
(CCK). 17th Annual Meeting Society for Neuroscience, New Orleans, LA, Nov. 16-21, pp. 586, 1987.
74.
Sahu, A., Crowley, W.R. and Kalra, S.P.: Hypothalamic neuropeptide Y (NPY) secretion decreases in
aged male rats: Implications for reproductive aging. 70th Annual Meeting Endocrine Society, New
Orleans, LA, June 8-11, pp. 72, 1988.
59
75.
Jacobson, W. and Kalra, S.P.: Progesterone-induced LH surge is associated with a decrease in
mediobasal hypothalamic opioid binding. 70th Annual Meeting Endocrine Society, New Orleans, LA,
June 8-11, pp. 319, 1988.
76.
Sahu, A., Kalra, S.P., Crowley, W.R. and Kalra, P.S.: Testosterone stimulates neuropeptide Y levels
in selected hypothalamic sites: Effects of aging. 18th Annual Meeting Society for Neuroscience,
Toronto, Ontario, CAN, Nov. 13-18, 14:1191, 1988.
77.
Kalra, S.P., Sahu, A., Dube, M.G. and Kalra, P.S.: Neuropeptide K suppresses feeding in the rat.
18th Annual Meeting Society for Neuroscience, Toronto, Ontario, CAN, Nov. 13-18, 14:761, 1988.
78.
Kalra, P.S., Phelps, C.P. and Kalra, S.P.: In vivo pulsatile LHRH release into the anterior pituitary
(AP) of the male rat. 18th Annual Meeting Society for Neuroscience, Toronto, Ontario, CAN, Nov. 1318, 1988.
79.
Jacobson, W., Sahu, A. and Kalra, S.P.: Dynamic changes in LHRH concentration in hypothalamic
sites following premature induction of the proestrus LH surge with an opioid antagonist. 18th Annual
Meeting Society for Neuroscience, Toronto, Ontario, CAN, Nov. 13-18, 14:438, 1988.
80.
Dube, M.G., Sahu, A., Kalra, S.P. and Jacobson, W.: Mediobasal and preoptic area opioid binding
sites are decreased following transection of the ascending noradrenergic pathway. 18th Annual
Meeting Society for Neuroscience, Toronto, Ontario, CAN, Nov. 13-18, 14:702, 1988.
81.
Masotto, C., Sahu, A. and Kalra, S.P.: Progesterone is required for naloxone (NAL)-induced LH
surge. 18th Annual Meeting Society for Neuroscience, Toronto, Ontario, CAN, Nov. 13-18, 14:1068,
1988.
82.
Kalra, P.S., Sahu, A., Crowley, W.R. and Kalra, S.P.: NPY and catecholamines as regulators of LH
secretion. 5th International Symposium on Psychoneuroendocrinology in Reproduction, "Brain-mind
Interactions in Human Reproduction", Rome Italy, Oct. 2-4, 1988.
83.
Kalra, P.S., Sahu, A. and Kalra, S.P.: Interleukin-1 inhibits ovarian steroid-induced LH surge and
hypothalamic LHRH release. 71st Annual Meeting Endocrine Society, Seattle, WAS, June 21-24,
1989.
Sahu, A., Crowley, W.R. and Kalra, S.P.: Naloxone stimulates hypothalamic neuropeptide Y (NPY):
Evidence for an opioid-NPY link in the estrogen-induced LH hypersecretion. 71st Annual Meeting
Endocrine Society, Seattle, WAS, June 21-24, 1989.
84.
85.
Kalra, S.P.: Brain Endogenous opioids and reproduction. Conference on "Brain-gut Peptides and
Reproductive Hormone Section". Washington State University, Pullman, WAS, June 18-19, 1989.
86.
Sninsky, C.A., Sahu, A. and Kalra, S.P.: Elevated levels of neuropeptide Y (NPY) in hypothalamic
and gastrointestinal tissue in diabetes. Annual Meeting American Federation Clinical Research,
1989.
87.
Kalra, S.P., Dube, M.G. and Sahu, A.: Neuropeptide K inhibits progesterone-induced LH surge in
estrogen-primed ovariectomized rats. 19th Annual Meeting Society Neuroscience, Phoenix, AZ, Oct.
29 - Nov. 3, 15:1339, 1989.
88.
Sahu, A., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Brain stem projections are required for the
testosterone (T)-induced augmentation of median eminence neuropeptide Y (NPY). 19th Annual
Meeting Society Neuroscience, Phoenix, AZ, Oct. 29 - Nov. 3, 15:189, 1989.
60
89.
Crowley, W.R., Shah, G.V., Kennedy, D., Dockter, M.E. and Kalra, S.P.: Involvement of the calcium
messenger system in the stimulation of luteinizing hormone secretion by neuropeptide Y. 19th
Annual Meeting Society Neuroscience, Phoenix, AZ, Oct. 29 - Nov. 3, 15:189, 1989.
90.
Sahu, A., Crowley, W.R. and Kalra, S.P.: A selective sexually dimorphic response in the median
eminence neuropeptide Y (NPY). 72nd Ann. Mtg. Endocr. Soc., Atlanta, GA, June 20-23, pp. 1251,
1990.
91.
Parker, S.L., Carroll, B.L., Kalra, S.P. and Crowley, W.R.: Neuropeptide Y enhances the binding of a
GnRH analogue to anterior pituitary GnRH receptor sites. 72nd Ann. Mtg. Endocrine Soc., Atlanta,
GA, June 20-23, pp.457, 1990.
92.
Phillips, I., Kimura, B., Borra, P., Rejtman, M., Kalra, S.P. and Kalra, P.S.: High levels of brain
angiotensin precede the luteinizing hormone surge in female rats. 20th Ann. Mtg. Soc. Neurosci., St.
Louis, MO, Oct. 28 - Nov. 2, pp. 394, 1990.
93.
Sahu, A., Dube, M.G., Phelps, C.P. and Kalra, S.P.: Rapid decreases in neuropeptide Y (NPY) levels
and release in the paraventricular nucleus (PVN) during feeding in rats on scheduled feeding regimen
(SFR). 20th Ann. Mtg. Soc. Neurosci., St. Louis, MO, Oct. 28 - Nov. 2, pp. 977, 1990.
94.
Kalra, S.P., Sahu, A., Dube, M.G., Phelps, C.P., Kalra, P.S.: Food deprivation increases
neuropeptide Y (NPY) secretion in the paraventricular nucleus (PVN): A physiological role for NPY on
feeding behavior in the rat. 20th Ann. Mtg. Soc. Neurosci., St. Louis, MO, Oct. 28 - Nov. 2, pp. 977,
1990.
95.
Kalra, S.P., Sahu, A., Crowley, W.R. and Kalra, P.S.: Effect of calcium channel agonists and
antagonists on hypothalamic NPY and LHRH release in vitro. 73rd Ann. Mtg. Endocrine Society,
Washington, DC, June 19-22, pp. 286, abstract 1024. 1991.
96.
Sahu, A., Fuentes, M. and Kalra, S.P.: Absence of LH surge in aged and young rats treated
chronically with estradiol 17β (E2) is due to impairment in different neural mechanisms. 73rd Ann.
Mtg. Endocrine Society, Washington, DC, June 19-22, pp. 140, abstract 438, 1991.
97.
Dube, M.G., Phelps, C., Kalra, S.P. and Kalra, P.S.: Effect of an anorectic agent - Dexfenfluramine
(DF) on Neuropeptide Y (NPY) release in the paraventricular nucleus (PVN) of food-deprived rats.
21st Ann. Mtg. Soc. Neurosci. New Orleans, LA, Nov. 10-15, 17(1):142 abstract 57.4, 1991.
98.
Sahu, A., Phelps, C., White, J., Kalra, S.P., Crowley, W.R. and Kalra, P.S.: Steroidal modulation of
hypothalamic preproNPY mRNA and in vivo NPY secretion into the anterior pituitary of male rats.
21st Ann. Mtg. Soc. Neurosci., New Orleans, LA, Nov. 10-15, 17(1): 713, #284.4, 1991.
99.
Bonavera, J.J., Kalra, S.P. and Kalra, P.S.: Interleukin-1 effects on LH release: Mode of action. 21st
Ann. Mtg. Soc. Neurosci., New Orleans, LA, Nov. 10-15, 17(2):1197, abstract 475.8, 1991.
100.
Kalra, S.P., Fuentes, M., Fournier, A. and Crowley, W.R.: NPY Y1 receptor mediates the effects of
NPY on LH and LHRH secretion: Structural requirements. 21st Ann. Mtg. Soc. Neurosci., New
Orleans, LA, Nov. 10-15, 17(1):714, abstract 284.7, 1991.
101.
Kalra, S.P., Sahu, A., Dube, M.G. and Kalra, P.S.: Neuropeptide Y: Is it a physiological appetite
transducer? 1st Independent Conference of the Society for the Study of Ingestive Behavior.
Princeton, NJ, June 24-28, 1992.
102.
Kalra, P.S., Dube, M.G. and Kalra, S.P.: Tachykinins may mediate the inhibitory feedback effects of
testosterone on LH release. 74th Ann. Mtg. Endocrine Soc., San Antonio, TX, June 24-27, pp. 358,
abstract 1226, 1992.
61
103.
Kalra, P.S., Bonavera, J.J. and Kalra, S.P.: Cytokine and neuropeptide interaction in reproduction.
9th Internatl. Congr. Endocrinology, Nice France, August 30 - September 5, 1992.
104.
Sahu, A., Kalra, S.P. and Kalra, P.S.: Neuropeptides and Feeding. Ninth International Congress of
Endocrinology. Nice, France, August 30 - September 5, 1992.
105.
Sahu, A., Sninsky, C.A., Phelps, C.P., Dube, M.G., Kalra, P.S. and Kalra, S.P.: In vivo and in vitro
evidence that streptozotocin (STZ)-induced diabetic hyperphagia is due to increased neuropeptide Y
(NPY) secretion in the paraventricular nucleus (PVN). 22nd Ann. Mtg. Soc. Neurosci., Anaheim, CA,
October 25-30, 18(2):937, abstract 396.5, 1992.
106.
Dube, M.G., Sahu, A., Phelps, C.P., Kalra, P.S. and Kalra, S.P.: Neuropeptide Y (NPY) concentration
is decreased in the paraventricular nucleus (PVN) of rats exhibiting excessive weight gain produced
by ventromedial hypothalamic (VMH) lesions. 22nd Ann. Mtg. Soc. Neurosci., Anaheim, CA, October
25-30, 18(2):937, abstract 396.6, 1992.
107.
Bonavera, J.J., Kalra, S.P. and Kalra, P.S.: Excitatory amino acid involvement in the Interleukin-1β
and tachykinin-induced effects on LH release in castrated male rats. 22nd Ann. Mtg. Soc. Neurosci.,
Anaheim, CA, October 25-30, 18(1):766, abstract 326.4, 1992.
108.
Sahu, A., Crowley, W.R. and Kalra, S.P.: NPY gene expression in the hypothalamus increases
before onset of the LH surge. 75th Ann. Mtg. Endocrine Soc., Las Vegas, NV, June 9-12, pp. 343,
abstract 1170, 1993.
109.
Bonavera, J.J., Kalra, P.S. and Kalra, S.P. Evidence implicating nitric oxide (NO) as a
neurotransmitter in the ovarian steroid-induced luteinizing hormone surge in ovariectomized rats.
75th Ann. Mtg. Endocrine Soc., Las Vegas, NV, June 9-12, pp. 538, abstract 1950, 1993.
110.
Kalra, P.S., Kalra, S.P.: Neuropeptide Y (NPY) stimulates hypothalamic β-endorphin (β-END) release
in vivo: Modulation by gonads. 23rd Ann. Mtg. Soc. Neurosci., Washington, DC, Nov. 7-12,
19(1):847, abstract 349.6, 1993.
111.
Sahu, A., Dube, M.G., Phelps, C.P., Sninsky, C.A., Kalra, P.S. and Kalra, S.P.: In vivo and in vitro
evidence that neuropeptide Y (NPY) secretion in the paraventricular nucleus (PVN) is regulated by
peripheral insulin. 23rd Ann. Mtg. Soc. Neurosci., Washington, DC, Nov. 7-12, 19(3):1821, abstract
743.16, 1993.
112.
Dube, M.G., Xu, B., Kalra, P.S. and Kalra, S.P.: Immunoneutralization of neuropeptide Y (NPY)
suppresses nighttime feeding. 23rd Ann. Mtg. Soc. Neurosci., Washington, DC, Nov. 7-12,
19(2):1264, abstract 522.6, 1993.
113.
Horvath, T.L., Kalra, S.P., Naftolin, F. and Leranth, C.: Evidence for a neuropeptide Y  Galanin  βendorphin pathway in the rat hypothalamus. 23rd Ann. Mtg. Soc. Neuroscience, Washington, DC,
Nov. 7-12, 19:1693, abstract 696.1, 1993.
114.
Phelps, C.P., Sahu, A., Oliver, J., Ma, X-L, Kalra, P.S., Kalra, S.P., Menzies, R.A., Horvath, E., Poole,
L.L. and Denker, M.: Release of interleukin-1β (IL-1β) into hypothalamic extracellular fluid (ECF) in
rats. 23rd Ann. Mtg. Soc. Neuroscience, Washington, DC, Nov. 7-12, 19(1):502, abstract 208.7,
1993.
115.
Bonavera, J.J., Sahu, A. and Kalra, S.P.: Chronic morphine treatment enhances LH and LHRH
release in response to NMDA in ovariectomized, estradiol-primed rats. 23rd Ann. Mtg. Soc.
Neuroscience, Washington, DC, Nov. 7-12, 19(1):848, abstract 349.7, 1993.
62
116.
Kalra, S.P.: An orexigenic Neuropeptide Y-galanin-opioid network in the hypothalamus. Benjamin
Franklin/Lafayette Seminar, La Napoule, France, May 29 - June 4, 1994.
117.
Kalra, P.S., Dube, M.G. and Kalra, S.P.: Stimulation of hypothalamic tachykinin levels and release by
IL-1β. 76th Ann. Mtg. Endocrine Soc., Anaheim, CA, June, 1994.
118.
Xu, B., Sahu A., Crowley, W.R. and Kalra, S.P.: Disinhibition of opioids rapidly stimulates
hypothalamic NPY gene expression: A link with the preovulatory GnRH secretion. 76th Ann. Mtg.
Endocrine Soc., Anaheim, CA, June, pp. 310, abstract 438, 1994.
119.
Sahu, A., Crowley, W.R. and Kalra, S.P.: Hypothalamic NPY gene expression before the onset of the
preovulatory LH surge. 76th Ann. Mtg. Endocrine Soc., Anaheim, CA, June, pp. 466, abstract 1063,
1994.
120.
Kalra, S.P. and Bonavera, J.J.: Nitric oxide, neuropeptides and pituitary hormone secretion. 3rd
Internatl. Congr. Neuroendocrinol., Budapest, Hungary, July 3-8, 1994.
121.
Kalra, S.P., Dube, M.G., Finkelstein, J. and Sahu, A.: Neuropeptide Y (NPY) release from the
paraventricular nucleus (PVN) of genetically obese and lean Zucker rats. 2nd Independent Mtg. Soc.
Study Ingest. Behav., McMaster University, Hamilton, Ontario, CAN., Aug. 16 - 20, 1994.
122.
Kalra, P.S., Bonavera, J.J., Dube, M.G., Crowley, W.R. and Kalra, S.P.: Inhibition of endogenous
neuropeptide Y (NPY) synthesis by antisense oligodeoxynucleotide administration suppresses the
progesterone-induced LH surge. (Abst.) 24th Ann. Mtg. Soc. Neuroscience, Miami Beach, FL, Nov.
13-18, 20:1059, abstract 436.8, 1994.
123.
Bonavera, J.J., Sahu, A., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: The excitatory effects of nitric
oxide (NO) on cyclic LH surges may be mediated by the neuropeptide Y-LHRH axis in the
hypothalamus. (Abst.), 24th Ann. Mtg. Soc. Neuroscience, Miami Beach, FL, Nov. 13-18, 20:639,
abstract 272.12, 1994.
124.
Sahu, A., Sninsky, C.A. and Kalra, S.P.: Hypothalamic neuropeptide Y (NPY) upregulation precedes
the onset of diabetic hyperphagia. (Abst.) 24th Ann. Mtg. Soc. Neuroscience, Miami Beach, FL, Nov.
13-18, 20:1285, abstract 528.6, 1994.
125.
Xu, B., Sahu, A., Hyde, J.F. and Kalra, S.P.: Evidence that Galanin (GAL) is a component of the
LHRH pulse generator network in the hypothalamus. 24th Ann. Mtg. Soc. Neuroscience, Miami
Beach, FL, Nov. 13-18, 20:638, abstract 272.8, 1994.
126.
Kalra, S.P., Dube, M.G. and Kalra, P.S.: NPY immunoneutralization suppresses feeding in VMHlesioned hyperphagic rats. 24th Ann. Mtg. Soc. Neuroscience. Miami Beach, FL, Nov. 13-18,
20:1285, abstract 528.7, 1994.
127.
Crowley, W.R., Parker, S.L., Kalra, S.P., Fournier, A. and St. Pierre, S.: Differential regulation of
hypothalamic neuropeptide Y (NPY) Y1 and Y2 receptors by ovarian hormones in female rats. 24th
Ann. Mtg. Soc. Neuroscience, Miami, FL, Nov. 13-18, 20:99, abstract 46.8, 1994.
128.
Kalra, S.P.: Control of LH Surge. 14th Joint Meeting of the British Endocrine Societies, Bristol,
England, March 25-31, 1995.
129.
Xu, B., Crowley, W.R., Kalra, P.S. and Kalra, S.P.: Blockade of inhibitory influence of endogenous
opioid peptide (EOP) promotes new synthesis of neuropeptide Y in association with GnRH surge:
Application of NPY mRNA antisense oligodeoxynucleotides. 77th Ann. Mtg. Endocrine Soc.,
Washington, DC, June 14-17, 1995.
63
130.
Sahu, A. and Kalra, S.P.: The pattern of dynamic changes in median eminence (ME) neuropeptide Y
(NPY) concentrations is altered in middle-aged rats on proestrus. 77th Ann. Mtg. Endocrine Soc.,
Washington, DC, June 14-17, 1995.
131.
Pu, S., Xu, B., Kalra, S.P. and Kalra, P.S.: Steroidal regulation of nitric oxide release in the medial
preoptic area in response to the excitatory amino acid, N-methyl-D-aspartate (NMDA): Correlation
with LH secretion. 77th Ann. Mtg. Endocrine Soc., Washington, DC, June 14-17, 1995.
132.
Pu, S., Kalra, S.P. and Kalra, P.S.: Regulation of nitric oxide (NO) release by endogenous opioid
peptides (EOP) in the medial preoptic area (MPOA): Correlation with LH secretion. 25th Ann. Mtg.
Soc. Neurosci., San Diego, CA, Nov. 11-16, 1995.
133.
Xu, B., Kalra, P.S., Crowley, W.R. and Kalra, S.P.: Mechanism of excitatory effects of neuropeptide
Y (NPY) on episodic LH secretion: Critical role of newly synthesized NPY. 25th Ann. Mtg. Soc.
Neurosci., San Diego, CA, Nov. 11-16, 1995.
134.
Sahu, A., Xu, B., Horvath, T., Leranth C., Crowley, W.R. and Kalra, S.P.: Evidence that galanin (GAL)
may participate in stimulation of LH secretion by neuropeptide Y. 25th Ann. Mtg. Soc. Neurosci., San
Diego, CA, Nov. 11-16, 1995.
135.
Kalra, S.P.: NPY and Food Intake. Ann. Conf. of the NAASO-SSIB, Baton Rouge, LA, Oct. 12-17,
1995.
136.
Kalra, P.S., Xu, B., Krause, J.E. and Kalra, S.P.: Interleukin-1β stimulates preprotachykinin (PPT)
gene expression in the hypothalamus. (Abst.) The Third International Congress of the International
Society for Neuroimmunomodulation. Bethesda, MD, Nov.13-15, 1996.
137.
Kalra, S.P., Xu, B., Dube, M., Kaibara, A., Martin, D. And Moldawer, L.L.: Ciliary neurotropic factors is
a potent anorectic cytokine acting through hypothalamic neuropeptide Y. 26th Ann. Mtg. Soc.
Neurosci, Washington, DC, Nov. 16-21, 22:1352, abstract 536.13, 1996.
138.
Pu, S., Kalra, P.S. and Kalra, S.P.: Is an increase in nitric oxide efflux in the medial preoptic area
coupled to the preovulatory GnRH surge? 26th Ann. Mtg. Soc. Neurosci, Washington, DC, Nov. 1621, 22:958, abstract 379.3 1996.
139.
Dube, M.G., Xu, B., Kalra, S.P. and Kalra, P.S.: Neurotoxin-induced transient hyperphagia is
negatively correlated with hypothalamic neuropeptide Y. 26th Ann. Mtg. Soc. Neurosci, Nov. 16-21,
22:466, abstract 184.15, 1996.
140.
Xu, B., Kalra, P.S. and Kalra, S.P.: Food restriction upregulates hypothalamic NPY gene expression:
Loss of daily rhythm. 26th Ann. Mtg. Soc. Neurosci, Nov. 16-21, 22:1685, abstract 663.5,1996.
141.
Kalra, P.S., Dube, M.G. and Kalra, S.P.: Increased neuropeptide Y (NPY)-receptor sensitivity may
underlie hyperphagia and obesity: A novel mechanism. Ann. Conf. North Amer. Assoc. For the Study
of Obesity, Oct. 12-15, 1996.
142.
Kalra, S.P., Xu, B., Dube, M.G., Kaibara, A. Martin, D. and Moldawer, L.L. Ciliary neurotropic factor
is a potent anorectic cytokine acting through hypothalamic neuropeptide Y. 2nd Mtg. Natl. Leaders in
Women=s Health, University of Florida Center of Genome Sciences & Public Policy, Gainesville, FL,
Feb. 27- March 1, 1997.
143.
Dube, M.G., Xu, B., Kalra, S.P. and Kalra, P.S.: 6-hydroxydopamine (6-OHDA)-induced hyperphagia
is associated with altered patterning in NPY and leptin signaling. Ann. Mtg. Soc. Study Ingest.
Behav., Baltimore, MD, July 16-20, 1997.
64
144.
Sahu, A. and Kalra, S.P.: Evidence suggesting aging-dependent alteration in facilitatory action of
NPY on LHRH-induced LH Secretion. 27th Ann. Mtg. Soc. Neurosci., New Orleans, LA, Oct. 25-30,
1997.
145.
Yokosuka, M., Xu, B., Pu, S. and Kalra, S.P.: The magnocellular part of the paraventricular
hypothalamic nucleus (PVN): A selective site for inhibition of NPY-induced food intake by leptin. 27th
Ann. Mtg. Soc. Neurosci. New Orleans, LA, Oct. 25-30, 23:1344, abstract 337.12, 1997.
146.
Pu, S., Jain, M., Horvath, T.L., Diano, S. and Kalra, S.P.: Coexistence of neuropeptide Y (NPY) and
γ-aminobutyric acid (GABA) in the hypothalamus: interactive effects on feeding. 27th Ann. Mtg. Soc.
Neurosci., New Orleans, LA, Oct. 25-30, 23:1344, abstract 528.3, 1997.
147.
Xu, B., Kalra, P.S., Farmerie, W.G. and Kalra, S.P.: Endogenous neuropeptide Y (NPY)
hypersecretion upregulates hypothalamic Y1 and not Y5 gene expression: A role in appetite
stimulation. 27th Ann. Mtg. Soc. Neurosci.,New Orleans, LA, Oct. 25-30, 23:1343, abstract 528.2,
1997.
Kalra, P.S., Dube, M.G., Xu, B., Farmerie, W.G. and Kalra, S.P.: Ventromedial nucleus (VMN) - a
putative site of negative feedback action of leptin on appetite: Implication for leptin resistance. 27th
Ann. Mtg. Soc. Neurosci., New Orleans, LA, Oct. 25-30, 23:851, abstract 337.6, 1997.
148.
149.
Dube, M.G., Xu, B., Kalra, S.P. and Kalra, P.S.: 6-hydroxydopamine (6-OHDA)-induced hyperphagia
is associated with increased NPY signaling. 27th Ann. Mtg. Soc. Neurosci., 23:254, abstract 102.22,
1997.
150.
Kalra, S.P., Dube, M.G., Xu, B., Farmerie, W.G. and Kalra, P.S.: Transient interruption of neural
signaling by neurotoxin injection into the ventromedial hypothalamus (VMH) induces temporary
hyperphagia and upregulates NPY Y1 receptor gene expression. 27th Ann. Mtg. Soc. Neurosci.,
23:1344, abstract 528.3, 1997.
151.
Jain, M.R., Dube, M.G., Kalra, S.P. and Kalra, P.S.: Neuropeptide Y (NPY) release in the
paraventricular nucleus (PVN) is decreased during transient hyperphagia induced by microinjection of
colchicine into the ventromedial hypothalamus. 80 th Ann. Mtg. Endo. Soc. June 24-27, abstracts P3217, P-432, 1998.
152.
Pu, S., Dube, M.G., Xu, B., Kalra, S.P. and Kalra, P.S.: Induction of neuropeptide Y (NPY) gene
expression in novel hypothalamic sites in association with transient hyperphagia and body weight
gain. 80th Ann. Mtg. Endo. Soc. New Orleans, LA, June 24-27, abstracts P3-217, P-432, 1998.
153.
Xu, B., Kalra, P.S. and Kalra, S.P.: Food-restriction abolishes the daily rhythm in gene expression of
hypothalamic neuropeptide Y (NPY), Galanin (GAL), and β-endorphin (POMC) and adipocyte leptin
but not in leptin secretion. 80th Ann. Mtg. Endo. Soc. New Orleans, LA, June 24-27,abstracts P3-246,
P-437, 1998.
154.
Yokosuka, M., Xu, B., Kalra, P.S., and Kalra, S.P. Neuropeptide Y target neurons for stimulation of
feeding reside in the magnocellular paraventricular nucleus (mPVN). 28th Ann. Mtg. of Neuroscience,
Los Angeles, CA, Nov. 7-12, abstract, 24:11,11.2 1998.
155.
Dhillon, H., Dube, M.G., Kalra, P.S., and Kalra, S.P. Site specific upregulation of NPY Y5 receptors
in hyperphagic rats. 28th Ann. Mtg. of Neuroscience, Los Angeles, CA, Nov. 7-12, 24:12, abstract
11.5, 1998.
156.
Jain, M.R., Pu, S., and Kalra, S.P. Orexin B: A novel neuropeptide activates hypothalamic axes
regulating appetite and reproduction. 28th Ann. Mtg. of Neuroscience, Los Angeles, CA, Nov. 7-12,
24:269, abstract 110.1, 1998.
65
157.
Pu, S., Dube, M.G., Xu, B., Kalra, S.P., and Kalra, P.S. Microinjection of colchicine into the
hypothalamic Ventromedial nucleus upregulates galanin expression in association with transient
hyperphagia. 28th Ann. Mtg. of Neuroscience, Los Angeles, CA, Nov. 7-12, 24:447, abstract 175.3,
1998.
158.
Dube, M.G., Kalra, S.P., and Kalra, P.S. Food intake elicited by central administration of orexins:
Identification of hypothalamic sites of action. 28th Ann. Mtg. of Neuroscience, Los Angeles, CA, Nov.
7-12, 24:448, abstract 175.8, 1998.
159.
Pu, S., Kalra, P.S., and Kalra, S.P.: Energy homeostasis and reproduction are regulated by different
subpopulations of neuropeptide Y (NPY) neurons in the arcuate nucleus (ARC). 81st Ann. Mtg.
Endo. Soc., San Diego, CA, June 1999.
160.
Dhillon, H., Minter, R.M., Topping, D., Prima, V., Moldawer, L.L., Muzyzcka, N., Kalra, P.S., Kalra,
S.P., and Zolotukhin, S.: Long-term correction of obesity using centrally delivered rAAV encoding
anorexigenic cytokines. 2nd Ann. Mtg. American Soc. for Gene Therapy, Washington DC, June 9-13,
1999.
161.
Dube, M.G., Kalra, S.P., and Kalra, P.S.: Diminution of melanocortin signaling in hyperphagic rats.
29th Ann. Mtg. Soc. Neuroscience, Miami Beach, FL, Oct. 23-28, 1999.
162.
Jain, M.R., Pu, S., Kalra, P.S., and Kalra, S.P.: Stimulation of two modalities of pituitary luteinizing
hormone (LH) release in ovarian steroid-primed ovarectomized (ovx) rats may involve neuropeptide Y
Y1 and Y4 receptors. 29th Ann. Mtg. Soc. Neuroscience, Miami Beach, FL, Oct. 23-28, 1999.
163.
Dhillon, H., Zolotukhin, S., Kalra, S.P., and Kalra, P.S.: Sexual dimorphism in the response to leptin
gene therapy via a recombinant adeno-associated virus (rAAV) vector. 29th Ann. Mtg. Soc.
Neuroscience, Miami Beach, FL, Oct. 23-28, 1999.
164.
Sautin, Y., Zolotukhin, S., Dhillon, H., Beretta, E., Prima, V., Muzyczka, N., Kalra, P.S., Kalra, S.P.:
Activation of STAT-dependent signaling in rat hypothalamus by leptin, CNTF and LIF transgenes
delivered centrally via recombinant adeno-associated virus (rAAV) vectors. 2000 Keystone Symposia:
Molecular Control of Adipogenesis and Obesity, Taos, NM, Feb. 16-22, pp.151, abstract 417, 2000.
165.
Zolotukhin, S., Dhillon, H., Beretta, E., Prima, V., Moldawer, L., Scarpace, P., Kalra, P.S., Muzyczka,
N., and Kalra, S.P.: Control of body weight (BW) in lean and obese rodent models using centrally
delivered recombinant adeno-associated virus (rAAV) vectors encoding cytokines leptin, CNTF and
LIF. 2000 Keystone Symposia: Molecular Control of Adipogenesis and Obesity, Taos, NM, Feb. 1622,. pp.151 abstract 424, 2000.
166.
Beretta, E., Prima, V., Dhillon, H., Moldawer, LL, Muzyczka, N., Zolotukhin, S., Kalra, P.S.,
Kalra, S.P : Long-term Suppression of Weight Gain and Obesity by rAAV-LIF Therapy. The American
Society of Gene Therapy, Third Annual Meeting, Denver, CO, May 31 - June 4, pp. 5, abstract 77,
2000.
167.
Beretta, E., Dube, M., Dhillon, H., Prima, V., Zolotukhin, S., Muzyczka, N., Kalra, P.S., and Kalra,
S.P.: Leptin gene therapy reduces food intake and body weight without affecting onset of puberty and
reproductive cycle. 33rd Annual Meeting of Society for Study of Reproduction, Ann Arbor, MI. July
15-18, pp. 179, abstract # 186, 2000.
168.
Beretta, E., Dube, M., Dhillon, H., Prima, V., Zolotukhin, S., Muzyczka, N., Kalra, P.S., and Kalra,
S.P.: Effects of long-term suppression of food intake, body weight (BW) and metabolic hormones
induced by central leptin gene therapy on the hypothalamic control of reproductive cycle. 30 th Annual
Meeting Society of Neuroscience, New Orleans, LA, Nov. 4-9, p2, abstract 7.5, 2000.
66
169.
Dhillon, H., Ge, Y.L., Scarpace, P., Prima, V., Zolotukhin, S., Muzyczka, N., Kalra, S.P., and Kalra,
P.S. Central leptin therapy reveals differential dose-dependent effects on body weight (BW) gain,
energy intake and expenditure, and POMC gene expression. 30 th Annual Meeting Society of
Neuroscience, New Orleans, LA, Nov. 4-9, pp. 5, abstract 7.5L, 2000.
170.
Ge, Y.L, Ohta, T., Driscoll, D., Nicolls, R., Kalra, S.P. Abnormal levels of POMC and AgrP mRNA in
the hypothalamus of neonatal Prader-Willi Syndrome (PWS) mice. 30th Annual Meeting Society of
Neuroscience, New Orleans, LA, Nov. 4-9, pp. 993, abstract 371.2, 2000.
171.
Keen-Rhinehart, E., Zolotukhin, S., Mczyczka, N., Kalra, S.P., Kalra, P.S. Leptin receptor gene
therapy in the arcuate nucleus of fa/fa Zucker rats restores estrous cyclicity. 30 th Annual Meeting
Society of Neuroscience, New Orleans, LA, Nov. 4-9, pp.1276, abstract 472.10, 2000.
172.
Kalra, S.P., and Kalra, P.S. Leptin and neurocytokine gene transfer to probe the etiology of
hypothalamus based obesity and energy expenditure. Society for the Science of Ingestive Behavior,
Philadelphia, PA, June 26-30, pp. 45, 2001.
173.
Bagnasco, M., Dube, M.G., Dhillon, H., Kalra, P.S., and Kalra, S.P. Microinjection of recombinant
adeno-associated virus vector encoding rat leptin gene (rAAV-leptin) in discrete hypothalamic sites
suppressed weight, adiposity and plasma insulin for extended period in adult rats. Society for the
Science of Ingestive Behavior, Philadelphia, PA, June 26-30, pp. 53, 2001.
174.
Beretta, E., Dube, M.G., Dhillon, H., Kalra, P.S. and Kalra S.P. Central leptin gene therapy in
prepubertal rats reduces weight gain, metabolic hormones, blood leptin and insulin levels but
augments energy expenditure postpubertally for extended period. Society for the Science of
Ingestive Behavior, Philadelphia, PA, June 26-30, pp. 72, 2001.
175.
Dube, M.G., Beretta, E., Dhillon, H., Kalra, S.P., and Kalra, P.S. Central leptin gene therapy blocks
high fat diet-induced weight gain, hyperinsulinemia, hyperleptinemia and leptin resistance in rats.
Society for the Science of Ingestive Behavior, Philadelphia, PA, June 26-30, pp. 53, 2001.
176.
Beretta, E., Dube, M.G., Kalra, P.S. and Kalra, S.P. Central leptin gene therapy in pre-pubertal rats
differentially affects hypothalamic neuropeptide gene expression for extended periods in association
with changes in energy intake and expenditure. 31 st Annual Meeting Society for Neuroscience, San
Diego, CA, Nov.10-15, pp. 294, Abs # 579.7, 2001.
177.
Bagnasco, M., Dube, M.G., Kalra, P.S., and Kalra, S.P. Microinjection of recombinant adenoassociated virus encoding leptin gene (rAAV-lep) into the paraventricular nucleus (PVN) blocks high
fat diet (HFD)- induced obesity, hyperleptinemia and hyperinsulinemia. 31 st Annual Meeting Society
for Neuroscience, San Diego, CA, Nov.10-15, pp. 294, Abs # 579.5, 2001.
178.
Rhinehart, E., Kalra, SP, Zolotukhin, S., Kalra, PS. Leptin receptor gene delivery to the hypothalamic
arcuate nucleus (ARC) of Zucker rats stimulates the reproductive axis and alleviates diabetes. 31 st
Annual Meeting Society for Neuroscience, San Diego, CA, Nov.10-15, pp. 295, Abs # 579.10, 2001.
179.
Kalra, S.P. and Kalra, P.S. Gene therapy for appetite and body weight regulation: all in the brain.
10th World Congress on Menopause, Berlin, Germany, June 10-14, 2002.
180.
Kalra, P.S. and Kalra, S.P. Central leptin gene therapy: a model for the study of caloric restriction
induced longevity. 33rd Annual Meeting of the American Society for Neurochemistry, Palm Beach, FL,
June 22-25, 2002.
181.
Rhinehart, E., Kalra, SP, Kalra, PS. Leptin Receptor Gene Therapy in the Arcuate Nucleus of
Female Obese Koletsky Rats Increases Energy Expenditure and Decreases Rate of Body Weight
Gain. 32nd Annual Society for Neuroscience Meeting, Orlando, FL, Nov. 2-7, pp52 Abs 320.6, 2002.
67
182.
Ueno, N., Dube, MG, Kalra, PS, Kalra, SP. Central leptin gene therapy increases insulin sensitivity
and suppresses weight without affecting food intake. 32 nd Annual Society for Neuroscience Meeting,
Orlando, FL, Nov. 2-7, pp781, Abs 573.9, 2002.
183.
Dube, MG, Kalra, SP, Kalra, PS. The melanocortin MC3/MC4 receptor agonist MTII blocks food
intake (F1) in PVN-lesioned rats exhibiting hyperphagia and excess body weight (BW) gain. 32 nd
Annual Society for Neuroscience Meeting, Orlando, FL, Nov. 2-7, pp52, Abs. 300.4, 2002.
184.
Bagnasco, M., Dube, MG, Kalra, PS, Kalra, SP. Leptin overexpression in the medial preoptic area
(MPOA) induced by microinjection of rAAV vector encoding leptin decreases weight by selectively
increasing thermogenic energy expenditure. 32 nd Annual Society for Neuroscience Meeting, Orlando,
FL, Nov. 2-7, pp52, Abs # 320.7 2002.
185.
Holmberg, SH, Dube, MG, Beretta, E., Bagnasco, M. Kalra, SP, Larhammar, D., Kalra PS.
Microarray analysis of hypothalamic gene expression following central leptin gene therapy. 32 nd
Annual Society for Neuroscience Meeting, Orlando, FL, Nov.2-7, pp 78, 573.8, 2002.
186.
Pu, S, Dube, MG, Kalra, SP, and Kalra PS. Permanent interruption of information flow between
hypothalamus and hindbrain produces obesity accompanied by a selective dark-phase hyperphagia
and hyperinsulinemia. 33rd Annual Society for Neuroscience Meeting, New Orleans, LA, Nov. 8-12,
pp, 2003, pp W-33, Abs #831.7.
187.
Ueno, N., Dube, MG, Katz, A, Kalra, PS, and Kalra, SP. Leptin inhibits ghrelin-induced obesity by
two distinct central and peripheral mechanisms: effects on adiponectin. 33rd Annual Society for
Neuroscience Meeting, New Orleans, LA, Nov. 8-12, 2003, pp. Su-81, Abs #283.8.
188.
Lecklin, A, Dube, MG, Katz, A, Torto, R, Kalra, PS, and Kalra, SP. Effects of central leptin gene
therapy - induced reduction in weight, food intake and metabolic hormones on fertility and postnatal
programming. 33rd Annual Society for Neuroscience Meeting, New Orleans, LA, Nov. 8-12, 2003, pp.
Su-81, Abs #283.9.
189.
Rhinehart, EK, Kalra, SP, Kalra PS. Leptin receptor replacement in the medial preoptic area (MPOA)
of female obese Koletsky rats increases energy expenditure and stimulates the reproductive axis.
33rd Annual Society for Neuroscience Meeting, New Orleans, Nov. 8-12, 2003, ppW-31, Abs #827.14.
190.
Otukonyong, E, Torto, R, Dube, MG, Kalra, PS, Kalra, SP. Altered rhythmicity in peripheral hormonal
feedback may encode dietary obesity. 33 rd Annual Society for Neuroscience Meeting, New Orleans,
LA, Nov. 8-12, 2003, pp Su-81, Abs #283.10.
191.
Crowley, WR, Ramoz, G., Torto, R., Kalra, SP. Up-regulation of Hypothalamic Neuropeptide Y (NPY)
and Agouti-related peptide (AgRP) during lactation in rats: Evidence for mediation by reduced
secretion of leptin. 33rd Annual Society for Neuroscience Meeting, New Orleans, LA, Nov. 8-12,
2003, pp,t-34, Abs #615.9.
192.
Boghossian, S, Lecklin, A, Dube MG, Kalra PS and Kalra SP. Increased leptin transgene expression
in the brain stem suppresses body weight (BW) gain and serum leptin and adiponectin for extended
period. 34th Annual Society for Neuroscience Meeting, San Diego, CA, Oct. 23-27, 2004, pp T-91,
Abs #763.12.
193.
Kalra, SP, Ueno, N, Boghossian, S, and Kalra PS. Leptin transgene expression in the hypothalamus
reduces mortality and increases lifespan. 34 th Annual Society for Neuroscience Meeting, San Diego,
CA, Oct. 23-27, 2004, pp M-103, Abs #565.15.
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194.
Dube, MG, Torto, R., Kalra, SP, and Kalra, PS. Decreased AGRP expression in paraventricular
(PVN)- and Ventromedial hypothalamic (VHM)- lesioned rats exhibiting hyperphagia and excess body
weight (BW). 34th Annual Society for Neuroscience Meeting, San Diego, CA, Oct. 23-27, 2004, pp
Su-6, Abs #147.4.
195.
Torto, R, Boghossian, S., Dube, MG, Kalra, SP, and Kalra, PS. Central leptin insufficiency produced
by ovariectomy stimulates hyperphagia and adiposity. 34th Annual Society for Neuroscience Meeting,
San Diego, CA, Oct. 23-27, 2004, pp M-32, Abs #427.3
196.
Iwaniec, UT, Dube, MG, Torto, R, Turner, RT, Wronski, TJ, Kalra, SP. Central leptin gene therapy to
reduce breast cancer risk factors. Era of Hope Department of Defense Breast Cancer Research
Program Meeting Proceedings, Philadelphia, PA June 8-11, 2005, p. 238.
197.
Iwaniec, UT, Boghossian, S., Dube, MG, Torto, R., Arzaga, RR, Wronski, TJ, and Kalra SP. Effects
of central leptin gene therapy on weight reduction and cancellous bone mass in female rats. 27 th
Annual Meeting of the American Society of Bone and Mineral Research, Nashville, TN September 2327, Abs #, 2005.
198.
Dube MG, Torto, R, Kalra SP, Kalra PS. Paraventricular nucleus (PVN)-lesioned rats exhibit
increased food intake (FI) in response to NPY injection along with decreased AgrP expression. North
American Assoc. for the Study of Obesity annual meeting, Vancouver British Columbia, Canada,
October 15-19, Abs #172-P, pp A45, 2005.
Boghossian, S. Dube, MG, Kalra, PS Kalra SP. Increased leptin expression selectively in the
hypothalamus using gene transfer technology suppresses pancreatic insulin hypersecretion. North
American Assoc. for the Study of Obesity annual meeting, Vancouver British Columbia, Canada,
October 15-19, Abs #633-P, pp A165, 2005.
199.
200.
Torto, R, Dube, MG, Kalra PS, Kalra SP. Ovariectomy-induced obesity is blocked by central leptin
gene therapy. North American Assoc. for the Study of Obesity annual meeting, Vancouver British
Columbia, Canada, October 15-19, Abs # 177-P, pp A46, 2005.
201.
Iwaniec UT, Boghossian S, Turner RT, and Kalra SP. Body mass influences bone mass independent
of leptin signaling. 29th Annual Meeting of the American Society of Bone and Mineral Research J.
Bone Mineral Res. 22(Suppl. 1):S101, 2007
202.
Kalra SP. Disruptions in the NPY-leptin link underlie the pandemic of diabetes and metabolic syndrome.
9th International NPY Meeting, Okinawa, Japan, March 16-20, 2008.
203.
Kojima S, Amitani H, Samish-Shima M, Asakura A, Inui A, Kalra PS and Kalra SP. Leptin as a substitute
for insulin therapy in insulin-deficient diabetes: correction of hyperglycemia and hyperphagia and
surviving without diabetic complications. Digestive Disease Week, AGA Institute, San Diego, May 17-22,
2008.
204.
Kojima S, Akihiro A, Inui A and Kalra SP. Leptin as a substitute for insulin therapy in insulin-deficient
diabetes-correction of hyperglycemia and hyperphagia and promotion of survival without diabetic
complications. 90th Annual Meeting of Endocrine Society, San Francisco, June 15-18, 2008.
205.
Kalra SP, Dube MG, Torto R, Iwaniec U and Kalra PS. Enhanced leptin production selectively in the
hypothalamus elevates plasma osteocalcin levels - a role in coupling bone remodeling and energy
homeostasis. 90th Annual Meeting of Endocrine Society, San Francisco, June 15-18, 2008.
206.
Vashistha H, Dube MG, Kalra SP, Meggs LG, and Malhotra A. Enhanced leptin expression in the
hypothalamus reverses p66ShcA dependent oxidative stress and myocyte apoptosis in Akita mice.
Annual Meeting of the American Heart Association, New Orleans, 2008.
69
207.
Kalra, SP and Kalra, PS. Gene-transfer technology to combat metabolic disease cluster for lifetime.
2nd International Conference on Drug Discovery and Therapy, Dubai, UAE, February 2, 2010.
208.
Kalra, SP. Leptin insufficiency in the hypothalamus confers disease cluster of metabolic syndrome: a
new insight. 14th International Congress of Endocrinology Symposium--Peptides, Kyoto, Japan, March
27, 2010.
70